<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype A
Gene PR
Mutation E35N
Rx >= 1 PI
IncludeMixtures No
References 8
Patients 14
Isolates 14
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Non-B Workgroup (2005)TK4006TK4006 NFV83N88SL10FI13V, I15V, K20I, E35N, M36I, R41K, K45R, R57Q, H69K, L89IA
Baxter (2006)48-33163316-30818DQ878217PINAI54A, V82F L10I, T12TK, I13V, G16A, L19LV, K20I, E35N, M36I, R41K, D60E, L63P, H69K, T74S, V77I, L89MA
 48-50215021-30606DQ878555PINAI54V, V82F, I84IV, L90ML33F, F53LL10I, V11L, I13V, I15V, G16E, L19P, K20I, E35N, M36I, K45V, L63T, H69K, L89MA
Jones (2012)182090182090JN670599PINAM46I, I54V, L76VL89VK20P, E35N, M36I, N37D, R41K, R57K, Q61N, I62V, L63P, A71T, T74S, V82I, Q92KA
 184144184144JN670673PINAM46I, I50IL, I54AV, V82AL24I, L33F, Q58EL10I, T12N, I13V, G16GE, K20I, E35N, M36I, N37E, R41K, R57K, D60E, Q61N, L63T, I72T, L89MA
Kouri (2012)CU544-09CU544-09JQ585255PINAM46I, I47V, I54V, I84V, L90ML10F, V11VI, L33I, Q58E, G73S, T74P, N88G, L89VI13AV, K14R, K20IT, E35N, M36I, N37D, R41K, I62V, L63V, H69K, K70RA
 CU1908-09CU1908-09JQ585320PINAM46I, I54V, V82F, L90ML33F, T74PK20I, E35N, M36I, R41K, K43R, F53Y, R57K, I62V, L63P, H69K, I85V, R87RK, L89MA
Mollan (2012)MK186MK186w26 RTV, ATV25  I13V, E35N, M36I, R41K, R57K, H69K, L89MA
Reynolds (2012)J7227J0722-2JN652210LPV   I13V, K20I, A22AV, E35N, M36I, R41K, H69K, V77I, L89MA
Diaz (2015)RenG14639RenG14639KT745667PINAM46IL, G48A, I54A, V82AL24I, L33F, Q58EL10I, I13V, K20M, E35N, M36I, N37ND, F53FY, R57K, Q61N, I62IV, L63LP, L89M, Q92QKA
 RenG13633RenG13633KT744661PINAM46I, I47A, I84V, L90ML10F, V11I, F53L, G73S, L89VI13V, I15V, K20T, E35N, M36I, R41K, K55R, R57K, Q61N, L63P, A71V, T74S, T91S, I93LA
 RenG15062RenG15062KT746090PINAM46L, I54V, I84V, L90MT74PL10I, V11L, I13V, I15V, L19LP, K20V, E35N, M36I, N37D, K55R, I62V, L63P, I64V, K70T, A71I, I72V, T91S, I93LA
 RenG12636RenG12636KT743664PINAD30N, V32VI, M46I, I47V, I54LVF53FL, L76LM, N88DL10V, T12IM, I13A, K20T, A22AV, E35N, M36I, N37ND, R41K, K45R, R57K, Q61N, L63C, A71V, T74S, L89T, Q92RA
Sutherland (2015)44_POSTKT351836LPV M46MI, V82VA L10I, I13V, K14KR, K20I, E35N, M36I, R41K, R57K, H69K, V77I, L89MA