<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype A
Gene PR
Mutation K20R
Rx >= 1 PI
IncludeMixtures No
References 14
Patients 59
Isolates 67
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Weidle (2001)PW_UG4399PW_UG4399a RTV69V82AL33FL10V, I13V, K20R, E35D, M36I, R41K, R57K, C67Y, H69K, L89MA
 PW_UG471PW_UG471aAY900678SQV13  I13V, G16E, K20R, E35D, M36I, R41K, R57K, H69K, K70R, L89MA
Gibb (2002)DMG106106_w41 NFV41M46LN83DI13V, G16A, K20R, A22V, E35D, M36I, R41K, R57K, I64IV, H69K, L89MA
 DMG6565_w9 NFV9  I13V, G16A, K20R, E35D, M36I, R41K, R57K, H69K, A71AV, L89MA
 DMG6868_w27 NFV27M46MI I13V, G16A, K20R, E35D, M36I, R41K, R57K, H69K, L89MA
  68_w30 NFV30  I13V, G16A, K20R, E35D, M36I, R41K, R57K, H69K, L89MA
 DMG9898_w55 NFV55  I13V, K20R, E35D, M36I, N37D, R41K, Q61QE, H69K, I72IV, L89MA
Maguire (2002)SW32381SW32381AY900671APV48M46L, I54L L10I, I13V, K20R, M36I, N37D, R41K, L63V, H69KA
Montes (2004)MB_patSAN01_SANC718AJ577992SQV, IDV, RTV143M46I, I84V, L90MG73S, L89VL10V, I13V, G16A, K20R, E35D, M36I, N37E, R41K, D60E, I62V, L63P, H69KA
 MB_patROI00_ROI705AJ577983SQV, RTV, IDV193  I13V, G16E, K20R, M36I, R41K, L63N, H69K, K70R, L89I, T91V, I93LA
Non-B Workgroup (2005)UK1436UK1436AY900801SQV, RTV, NFV123 N83DI13V, K14R, K20R, A22V, E35D, M36I, R41K, R57K, H69K, L89I, T91AA
 UK2088UK2088 RTV V82F I13V, K14R, I15V, K20R, E35D, M36I, R41K, I62V, L63LP, H69K, T74TS, L89I, L97LSA
 PL972860099AY901076IDV, RTV, ATV I54V, V82AL33I, F53L, N83DL10Y, I13V, G16E, K20R, A22AV, E35DN, M36I, N37ND, R41RK, L63T, H69K, T74S, L89M, T91AA
 TK2004TK2004 IDV181  I13V, K20R, E35D, M36I, R41K, R57K, H69K, K70R, L89MA
 TK2012TK2012 RTV, IDV, SQV186I54V, L90M L10V, I13V, K14R, I15V, K20R, E35D, M36I, R41K, R57K, I62V, H69K, T74S, L89IA
 TK3017TK3017 RTV174L90M L10V, I13V, G16E, K20R, E35D, M36I, R41K, L63T, H69K, L89MA
  TK3017a RTV222L90M L10V, I13V, G16E, K20R, E35D, M36I, P39PS, R41K, L63T, H69K, L89MA
  TK3017b RTV230L90M L10V, I13V, G16E, K20R, E35D, M36I, P39PS, R41K, L63T, H69K, L89MA
  TK3017c RTV249L90M L10V, I13V, G16E, K20R, E35D, M36I, P39PS, R41K, L63T, H69K, L89MA
 TK4009TK4009 IDV336  I13V, K14R, G16E, K20R, E35D, M36I, R41K, H69K, L89M, I93LA
 TK5005TK5005 SQV, IDV, RTV, NFV, LPV180G48V, I54T, V82A, L90M L10I, I13V, K14R, G17D, K20R, E34N, E35D, M36I, R41K, R57K, D60E, I62V, L63P, H69K, A71V, L89IA
  TK5005a SQV, IDV, RTV, NFV, LPV196G48V, I54T, L90M L10I, I13V, K14R, G17D, K20R, E34N, E35D, M36I, R41K, R57K, D60E, I62V, L63P, H69K, A71IV, L89I, I93IMA
 TK5008TK5008 IDV93  I13V, G16E, K20R, E35D, M36I, R41K, R57K, H69K, K70R, L89MA
 TK5012TK5012 IDV54  L10I, I13V, K14R, G16E, K20R, E35D, M36I, R41K, L63T, H69K, L89MA
  TK5012a IDV, LPV152  L10I, I13V, K14KR, G16E, K20R, E35D, M36I, R41K, L63T, H69K, L89MA
  TK5012b IDV, LPV191  L10IV, I13V, K14KR, G16E, K20R, E35D, M36I, R41K, L63T, H69K, L89MA
  TK5012c IDV, LPV215  L10I, I13V, K14KR, G16E, K20R, D25DG, E35D, M36I, R41K, L63ST, H69K, L89MA
 PL4311075401 IDV208  K20R, E35D, M36I, N37D, R41K, I62V, L63T, H69K, L89MA
Weber (2005)F76135F76135AY677380RTV65  Q7QH, T12V, K14R, K20R, E21K, E35D, M36I, N37D, R41K, R57K, L63V, H69K, L89MA
 F45753F45753AY677422SQV, NFV258  L10I, I13V, G16E, K20R, E35D, M36I, P39S, R41K, H69K, L89MA
 M41971M41971AY677401IDV, NFV, LPV181I54V, V82AL10F, L33IT4TS, I13V, G16E, L19LI, K20R, E35D, M36I, N37D, R41K, K45V, K55T, R57K, L63H, H69K, K70R, L89M, T91TSA
Baxter (2006)48-12021202-30702DQ877746PINAI54V, V82A, L90ML33F, N83DI13V, G16E, K20R, E35D, M36I, N37D, R41K, R57RK, L63N, H69K, K70R, L89I, T91V, I93LA
 48-12531253-30605DQ877778PINA  L10V, T12TP, I13V, K14R, G16E, K20R, E35D, M36I, R41K, R57RK, Q61QE, I62IV, L63CS, H69K, L89MA
 48-41864186-30408DQ878420PINAI54V, V82AL24I, L33I, Q58E, N83DL10I, I13V, G16E, K20R, A22V, E35D, M36I, N37D, R41K, L63T, H69K, I72V, T74A, L89M, T91V, I93LA
 48-42174217-30915DQ878451PINAM46L, I54V, I84V, L90ML33F, K43T, N88GL10I, I13V, K14R, K20R, E21Q, E35D, M36I, N37D, Q61N, I62V, L63Q, H69K, A71L, T74S, Q92R, I93MA
Sylla (2008)A2868A2868_C1EF525663IDV   L10I, I13V, G16E, K20R, E35D, M36I, R41K, H69K, K70R, I72R, L89MA
Steegen (2009)BV114BV114-1EU872122LPV4  I13V, G16E, K20R, E35D, M36I, R41K, Q61H, L63T, G68E, H69K, K70R, V82I, L89M, T91V, I93LA
Hamkar (2010)2Ir-HIV-DR-02GU724805PINA  I13V, K14I, L19Q, K20R, E35D, M36I, R41K, R57K, H69K, L89MA
 3Ir-HIV-DR-03GU724806PINA  I13V, K14I, L19Q, K20R, E35D, M36I, R41K, R57K, H69K, L89MA
 6Ir-HIV-DR-06GU724809PINA  I13V, K14I, L19Q, K20R, E35D, M36I, R41K, R57K, H69K, L89MA
 7Ir-HIV-DR-07GU724810PINA  I13V, K14I, L19Q, K20R, E35D, M36I, R41K, R57K, H69K, L89MA
 8Ir-HIV-DR-08GU724811PINA  I13V, K14I, L19Q, K20R, E35D, M36I, R41K, R57K, H69K, L89MA
 9Ir-HIV-DR-09GU724812PINA  I13V, K14I, L19Q, K20R, E35D, M36I, R41K, R57K, H69K, L89MA
 11Ir-HIV-DR-11GU724814PINA  T12K, I13V, K14I, L19Q, K20R, E35D, M36I, R41K, G49E, R57K, H69K, L89MA
 12Ir-HIV-DR-12GU724815PINA  I13V, K14I, L19Q, K20R, E35D, M36I, R41K, R57K, H69K, L89MA
 14Ir-HIV-DR-14GU724817PINA  I13V, L19Q, K20R, E35D, M36I, R41K, R57K, H69K, L89MA
 15Ir-HIV-DR-15GU724818PINA  I13V, L19Q, K20R, E35D, M36I, R41K, R57K, H69K, L89MA
 17Ir-HIV-DR-17GU724820PINA L23IQ2H, T12P, K14R, K20R, E35D, M36I, R41K, L63P, H69K, L89M, I93F, T96PA
 19Ir-HIV-DR-19GU724822PINA  I13V, L19Q, K20R, E35D, M36I, R41K, R57K, C67Y, H69K, L89MA
 21Ir-HIV-DR-21GU724824PINA  I13V, L19Q, K20R, E35D, M36I, R41K, R57K, C67Y, H69K, L89MA
 24Ir-HIV-DR-24GU724827PINA  I13V, K14I, L19Q, K20R, E35D, M36I, R41K, R57K, H69K, L89MA
 25Ir-HIV-DR-25GU724828PINA  I13V, L19Q, K20R, E35D, M36I, R41K, R57K, H69K, L89MA
 28Ir-HIV-DR-28GU724831PINA  I13V, K14I, L19Q, K20R, E35D, M36I, R41K, R57K, H69K, L89MA
 30Ir-HIV-DR-30GU724833PINA  T12P, K14R, K20R, E35D, M36I, R41K, L63P, H69K, L89M, I93LA
 31Ir-HIV-DR-31GU724834PINA  I13V, K14I, L19Q, K20R, E35D, M36I, R41K, R57K, H69K, L89MA
 34Ir-HIV-DR-34GU724837PINA  I13V, K14I, L19Q, K20R, E35D, M36I, R41K, R57K, H69K, L89MA
 35Ir-HIV-DR-35GU724838PINA  I13V, K14I, L19Q, K20R, E35D, M36I, R41K, R57K, H69K, L89MA
 37Ir-HIV-DR-37GU724840PINA  I13V, K14I, L19Q, K20R, E35D, M36I, N37F, R41K, R57K, E65G, I66V, H69K, L89MA
 38Ir-HIV-DR-38GU724841PINA  I13V, K14I, L19Q, K20R, A28P, E35D, M36I, R41K, R57K, H69K, L89MA
 40Ir-HIV-DR-40GU724843PINA  I13V, L19Q, K20R, E35D, M36I, R41K, R57K, C67Y, H69K, L89MA
 42Ir-HIV-DR-42GU724845PINA  I13P, K14I, L19Q, K20R, G27P, E35D, M36I, R41K, R57K, H69K, P81G, L89MA
Charpentier (2011)51CP 001 2273 Unknown, LPVNA  T12P, I13V, G16E, K20R, E35D, M36I, R41K, K55K*, L63T, E65EG, G68GE, H69KR, L89MA
Barber (2012)4882648826JQ361679LPV V32I, M46I, I47AL10F, L33I, L89VI13V, K20R, E35D, M36I, R41K, R57K, I62V, H69K, K70R, T74SA
 6778467784JQ361691LPV I54V I13V, G17D, K20R, E35D, M36I, R41K, R57K, D60E, I62V, L63I, H69K, L89MA
Van Zyl (2013)11791314KC423050LPV26  T12S, I13V, I15V, G16E, K20R, E35D, M36I, L63S, I64L, H69K, L89M, I93LA
 11961593KC423255LPV52 L33FI13V, K20R, M36I, R41K, D60E, Q61E, H69K, L89M, I93VA
Grossman (2014)20882088KC184354LPV52  L10V, G16E, K20R, E35D, M36I, R41K, H69K, L89M, I93LA