<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype A
Gene PR
Mutation K20R
Rx >= 1 PI
IncludeMixtures No
References 23
Patients 50
Isolates 60
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Weidle (2001)PW_UG4399PW_UG4399a RTV69V82AL33FL10V, I13V, K20R, E35D, M36I, R41K, R57K, C67Y, H69K, L89MA
 PW_UG471PW_UG471aAY900678SQV13  I13V, G16E, K20R, E35D, M36I, R41K, R57K, H69K, K70R, L89MA
Gibb (2002)DMG106106_w41 NFV41M46LN83DI13V, G16A, K20R, A22V, E35D, M36I, R41K, R57K, I64IV, H69K, L89MA
 DMG6565_w9 NFV9  I13V, G16A, K20R, E35D, M36I, R41K, R57K, H69K, A71AV, L89MA
 DMG6868_w27 NFV27M46MI I13V, G16A, K20R, E35D, M36I, R41K, R57K, H69K, L89MA
  68_w30 NFV30  I13V, G16A, K20R, E35D, M36I, R41K, R57K, H69K, L89MA
Papa (2002)63GR63AF385364RTV V82A I13V, K20R, E35D, M36I, N37D, R41K, L63P, H69K, L89M, I93LA
Montes (2004)MB_patSAN01_SANC718AJ577992SQV, IDV, RTV143M46I, I84V, L90MG73S, L89VL10V, I13V, G16A, K20R, E35D, M36I, N37E, R41K, D60E, I62V, L63P, H69KA
 MB_patROI00_ROI705AJ577983SQV, RTV, IDV193  I13V, G16E, K20R, M36I, R41K, L63N, H69K, K70R, L89I, T91V, I93LA
Chantratita (2005)G738G738DQ130229PINA  L10I, I13V, G16E, K20R, E35D, M36I, R41K, L63T, G68E, H69K, K70R, I72V, L89M, T91VA
Non-B Workgroup (2005)UK1436UK1436AY900801SQV, RTV, NFV123 N83DI13V, K14R, K20R, A22V, E35D, M36I, R41K, R57K, H69K, L89I, T91AA
 UK2088UK2088 RTV V82F I13V, K14R, I15V, K20R, E35D, M36I, R41K, I62V, L63LP, H69K, T74TS, L89I, L97LSA
 TK2004TK2004 IDV181  I13V, K20R, E35D, M36I, R41K, R57K, H69K, K70R, L89MA
 TK2012TK2012 RTV, IDV, SQV186I54V, L90M L10V, I13V, K14R, I15V, K20R, E35D, M36I, R41K, R57K, I62V, H69K, T74S, L89IA
 TK3017TK3017 RTV174L90M L10V, I13V, G16E, K20R, E35D, M36I, R41K, L63T, H69K, L89MA
  TK3017a RTV222L90M L10V, I13V, G16E, K20R, E35D, M36I, P39PS, R41K, L63T, H69K, L89MA
  TK3017b RTV230L90M L10V, I13V, G16E, K20R, E35D, M36I, P39PS, R41K, L63T, H69K, L89MA
  TK3017c RTV249L90M L10V, I13V, G16E, K20R, E35D, M36I, P39PS, R41K, L63T, H69K, L89MA
 TK5005TK5005 SQV, IDV, RTV, NFV, LPV180G48V, I54T, V82A, L90M L10I, I13V, K14R, G17D, K20R, E34N, E35D, M36I, R41K, R57K, D60E, I62V, L63P, H69K, A71V, L89IA
  TK5005a SQV, IDV, RTV, NFV, LPV196G48V, I54T, L90M L10I, I13V, K14R, G17D, K20R, E34N, E35D, M36I, R41K, R57K, D60E, I62V, L63P, H69K, A71IV, L89I, I93IMA
 TK5008TK5008 IDV93  I13V, G16E, K20R, E35D, M36I, R41K, R57K, H69K, K70R, L89MA
 TK5012TK5012 IDV54  L10I, I13V, K14R, G16E, K20R, E35D, M36I, R41K, L63T, H69K, L89MA
  TK5012a IDV, LPV152  L10I, I13V, K14KR, G16E, K20R, E35D, M36I, R41K, L63T, H69K, L89MA
  TK5012b IDV, LPV191  L10IV, I13V, K14KR, G16E, K20R, E35D, M36I, R41K, L63T, H69K, L89MA
  TK5012c IDV, LPV215  L10I, I13V, K14KR, G16E, K20R, D25DG, E35D, M36I, R41K, L63ST, H69K, L89MA
 PL4311075401 IDV208  K20R, E35D, M36I, N37D, R41K, I62V, L63T, H69K, L89MA
Weber (2005)F76135F76135AY677380RTV65  Q7QH, T12V, K14R, K20R, E21K, E35D, M36I, N37D, R41K, R57K, L63V, H69K, L89MA
 F45753F45753AY677422SQV, NFV258  L10I, I13V, G16E, K20R, E35D, M36I, P39S, R41K, H69K, L89MA
 M74228M74228AY677423NFV75  L10V, I13V, K14R, G16E, K20R, E35D, M36I, N37D, R41K, H69K, I72T, L89I, Q92KA
Baxter (2006)48-12021202-30702DQ877746PINAI54V, V82A, L90ML33F, N83DI13V, G16E, K20R, E35D, M36I, N37D, R41K, R57RK, L63N, H69K, K70R, L89I, T91V, I93LA
 48-12531253-30605DQ877778PINA  L10V, T12TP, I13V, K14R, G16E, K20R, E35D, M36I, R41K, R57RK, Q61QE, I62IV, L63CS, H69K, L89MA
 48-41864186-30408DQ878420PINAI54V, V82AL24I, L33I, Q58E, N83DL10I, I13V, G16E, K20R, A22V, E35D, M36I, N37D, R41K, L63T, H69K, I72V, T74A, L89M, T91V, I93LA
 48-50735073-30807DQ878583PINAI54V, V82A, L90ML33F, T74TPT4TS, I13V, K20R, E35D, M36I, N37D, R41K, F53I, I62IV, I66IF, H69R, L89IA
 48-50775077-30903DQ878587PINAM46L, I54V, V82AL24I, L33F, F53L, T74PL10I, I13V, L19I, K20R, E35D, M36I, N37D, Q61R, L63P, H69K, L89MA
Sylla (2008)A2868A2868_C1EF525663IDV   L10I, I13V, G16E, K20R, E35D, M36I, R41K, H69K, K70R, I72R, L89MA
Steegen (2009)BV114BV114-1EU872122LPV4  I13V, G16E, K20R, E35D, M36I, R41K, Q61H, L63T, G68E, H69K, K70R, V82I, L89M, T91V, I93LA
Barber (2012)4882648826JQ361679LPV V32I, M46I, I47AL10F, L33I, L89VI13V, K20R, E35D, M36I, R41K, R57K, I62V, H69K, K70R, T74SA
Kouri (2012)CU1-10CU1-10JQ585357PINA  P1R, W6G, P9H, I13V, I15V, G16E, K20R, E35D, M36I, R41K, R57K, L63A, E65D, H69K, K70R, L89MA
Avidor (2013)196196 APV M46I, I84VL10FI, L33FI13V, K20R, L24LV, E35D, M36I, N37D, R41K, K45R, R57K, I62IV, H69K, L89M, I93VA
Inzaule (2013)360360JQ914084LPV   K14R, G16E, K20R, E35D, M36I, R41K, K45R, R57K, I62V, L63V, H69K, I72V, L89MA
 472472JQ914071LPV   I13V, G16E, K20R, E35D, M36I, R41K, R57K, L63T, E65D, H69K, L89MA
  472JQ914073LPV   I13V, G16E, K20R, E35D, M36I, R41K, R57K, L63T, E65D, H69K, L89MA
  472JQ914066LPV, NFV   G16E, K20R, E35D, M36I, R41K, R57K, L63T, E65D, H69K, L89MA
Van Zyl (2013)O11961593KC423255LPV52 L33FI13V, K20R, M36I, R41K, D60E, Q61E, H69K, L89M, I93VA
Acharya (2014)DGP156DGP156KJ185326RTV, ATV   L10I, I13V, I15V, K20R, E35D, M36I, N37D, R41K, K45R, R57K, H69K, K70R, L89MA
 DGP122DGP122KJ185292LPV   L10V, I13V, I15V, K20R, E35D, M36I, N37D, R41K, K45R, R57K, H69K, K70R, L89MA
 DGP112DGP112KJ185282RTV, ATV   L10V, I13V, I15V, K20R, E35D, M36I, N37D, R41K, K45R, R57K, H69K, K70R, L89MA
Grossman (2014)20882088KC184354LPV52  L10V, G16E, K20R, E35D, M36I, R41K, H69K, L89M, I93LA
Kolomeets (2014)226226_363KJ870469LPV   I13V, K14R, K20R, E35D, M36I, N37D, R41K, R57K, H69K, L89MA
 307307_405KJ870500APV  L33F, F53FLL10LI, K14R, G16E, K20R, E35D, M36I, R41K, H69K, L89M, I93LA
 276276_507KJ870571APV   K14R, K20R, E35D, M36I, N37D, R41K, H69K, L89M, I93LA
 278278_510KJ870574PINA  G16A, K20R, E35D, M36I, R41K, Q58Q*, Q61E, H69K, L89MA
Diaz (2015)RenG15526RenG15526KT746554PINA  I15V, K20R, E35D, M36I, R41K, L63V, H69K, L89MA
Jenabian (2015)DR05DR05KF735816PINA  I13V, K20R, E35N, M36I, N37D, R41K, K43R, R57K, L63P, H69K, K70R, L89MA
Inzaule (2016)1.0361.036HM164120NFV   K14R, G16E, K20R, E35D, M36I, R41K, K45R, R57K, I62V, L63V, H69K, I72V, L89MA
Lopez (2016)2011-0262011-026KT385904PINA  G16E, K20R, E35D, M36I, R41K, L63X, G68E, H69K, K70R, V82VI, L89M, T91V, I93LA
Ndahimana Jd Riedel (2016)20662066KT982493LPV   L10I, I13V, K14R, K20R, E35D, M36I, N37D, R41K, K45R, R57K, L63V, E65D, H69K, L89MA
 21402140KT982495LPV M46I, I54V, L76V, V82A L10V, I13V, G16E, K20R, E35D, M36I, R41KT, R57K, L63R, H69K, L89I, T91SA
 20802080KT982497LPV   I13V, I15V, G16E, K20R, E35D, M36I, R41K, R57K, H69K, K70KR, L89MA
 21332133KT982485LPV M46I, I54V, V82A, I84VL10FI13V, G16E, K20R, E35D, M36I, N37E, R41K, K45I, R57K, Q61N, L63H, H69K, K70R, I72IT, L89MA