Protease Inhibitors

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Protease Inhibitors

Subtype	A
Gene	PR
Mutation	K20I
Rx	>= 1 PI
IncludeMixtures	No

References	13
Patients	25
Isolates	25

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	PIs	Wks	PIMajorDRMs	PIMinorDRMs	OtherMut	Subtype
Weidle (2001)	PW_UG473	PW_UG473	AF358758	RTV	40			I13V, K20I, E35D, M36I, R41K, H69K, L89M	A
	PW_56	PW_56	AY900821	SQV, IDV	61		L89MV	I13V, K14R, K20I, E35D, M36I, R41K, I62IV, H69K, T74TS	A
Yahi (2001)	NY_M35	M35	AY010399	NFV		M46I, L90M		L10I, I13V, K14R, G16E, K20I, E35DN, M36I, I62IV, L63S, C67D, H69R, I72T, L89M, I93IM	A
	NY_M72	M72	AY010434	IDV		M46MI, I84V		I13V, K20I, E35D, M36I, R41K, L63P, H69K, A71V, L89T	A
Papa (2002)	16	GR16	AF385360	IDV		M46I, N88S	K43T, L89V	I13V, K20I, E35DG, M36I, N37D, R41K, I62IV, H69K, A71T	A
Vergne (2002)	LV04B	LV04B	AJ313406	IDV	74			I13V, G17E, K20I, M36I, N37D, L63P, H69K, K70R, L89M	A
Gomez-Carrillo (2004)	103396	103396	AY365678	PI	NA	I54V		I13V, K20I, E35D, M36I, N37D, R41K, I62V, L63V, I66F, G68E, H69R, L89M, T91V	A
Non-B Workgroup (2005)	TK4006	TK4006		NFV	83	N88S	L10F	I13V, I15V, K20I, E35N, M36I, R41K, K45R, R57Q, H69K, L89I	A
	PL34031	55128		IDV, NFV	207	M46I, I84V	L89V	L10I, T12S, I13V, L19V, K20I, E35D, N37D, L63P, I66F, H69K, K70R, A71V	A
Weber (2005)	M50457	M50457	AY677433	NFV	94			L10I, T12S, I13V, K14KR, I15IV, K20I, E35D, M36I, N37S, R41K, K45R, H69K, A71V, L89T	A
	F78596	F78596	AY677480	IDV	18			L10I, I13V, I15L, K20I, E35D, M36I, L63S, H69K, L89M	A
	89M2626	89M2626	AY677414	SQV, NFV, RTV	261	I54V, L90M	F53L, L89V	L10I, I13V, K14R, K20I, E35D, M36I, N37E, R41K, R57K, H69K, A71V, T74S	A
Baxter (2006)	48-3316	3316-30818	DQ878217	PI	NA	I54A, V82F		L10I, T12TK, I13V, G16A, L19LV, K20I, E35N, M36I, R41K, D60E, L63P, H69K, T74S, V77I, L89M	A
	48-4153	4153-30326	DQ878387	PI	NA	M46I, I54L, L76V, I84V	L10F	I13V, G16E, K20I, L33L_L, E35D, M36I, R57K, Q61R, L63T, H69K, L89I, T91TS	A
	48-5021	5021-30606	DQ878555	PI	NA	I54V, V82F, I84IV, L90M	L33F, F53L	L10I, V11L, I13V, I15V, G16E, L19P, K20I, E35N, M36I, K45V, L63T, H69K, L89M	A
	48-5031	5031-30421	DQ878557	PI	NA	M46I, I54V, V82A	G73S	I13V, I15V, K20I, E35D, M36I, Q61H, L63D, H69K, A71V, L89T	A
Seyler (2007)	265	CS_265		IDV	66			L10V, I13V, L19P, K20I, M36I, R41K, K43R, L63LP, H69K, L89M	A
	547	CS_547		NFV	268		G48GR, V82VD	I13V, K14R, G16GR, K20I, M36IT, R41K, L63P, H69K, L89M	A
Koyalta (2009)	17	TCHAD-17	FJ688177	IDV	26	M46I, I84V		L10I, I13V, K14R, I15V, K20I, M36I, R41K, R57K, L63P, I66F, H69N, I72V, L89I	A
	33	TCHAD-33	FJ688184	IDV	26			L10I, I13V, G16A, K20I, E35D, M36I, R41K, H69Q, L89M	A
Charpentier (2011)	32	CP 001-144		Unknown, LPV	NA			I13V, K14R, G17E, K20I, E34K, M36I, N37D, P39M, L63T, I64M, H69K, K70KR, I72T, L89M	A
Jones (2012)	178278	178278	JN670478	PI	NA	I54V, V82VA, L90LM	L10F, F53L	I13V, K20I, E35D, M36I, N37D, R41K, I62V, L63V, H69K, K70R, T74A, L89M, T91V	A
	184144	184144	JN670673	PI	NA	M46I, I50IL, I54AV, V82A	L24I, L33F, Q58E	L10I, T12N, I13V, G16GE, K20I, E35N, M36I, N37E, R41K, R57K, D60E, Q61N, L63T, I72T, L89M	A
	199883	199883	JN671186	PI	NA	M46I, I54V, V82A, L90M	N88D	L10I, I13V, I15V, L19I, K20I, E35D, M36I, N37K, R41K, K45R, K55R, R57K, Q61N, L63P, C67F, A71T, I72E	A
Reynolds (2012)	J7227	J0722-2	JN652210	Unknown, RTV, LPV	NA			I13V, K20I, A22AV, E35N, M36I, R41K, H69K, V77I, L89M	A

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