<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype A
Gene PR
Mutation K20I
Rx >= 1 PI
IncludeMixtures No
References 18
Patients 37
Isolates 37
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Weidle (2001)PW_UG473PW_UG473AF358758RTV40  I13V, K20I, E35D, M36I, R41K, H69K, L89MA
 PW_56PW_56AY900821SQV, IDV61 L89MVI13V, K14R, K20I, E35D, M36I, R41K, I62IV, H69K, T74TSA
Yahi (2001)NY_M35M35AY010399NFV M46I, L90M L10I, I13V, K14R, G16E, K20I, E35DN, M36I, I62IV, L63S, C67D, H69R, I72T, L89M, I93IMA
 NY_M72M72AY010434IDV M46MI, I84V I13V, K20I, E35D, M36I, R41K, L63P, H69K, A71V, L89TA
Papa (2002)16GR16AF385360IDV M46I, N88SK43T, L89VI13V, K20I, E35DG, M36I, N37D, R41K, I62IV, H69K, A71TA
Vergne (2002)LV04BLV04BAJ313406IDV74  I13V, G17E, K20I, M36I, N37D, L63P, H69K, K70R, L89MA
Gomez-Carrillo (2004)103396103396AY365678PINAI54V I13V, K20I, E35D, M36I, N37D, R41K, I62V, L63V, I66F, G68E, H69R, L89M, T91VA
Non-B Workgroup (2005)TK4006TK4006 NFV83N88SL10FI13V, I15V, K20I, E35N, M36I, R41K, K45R, R57Q, H69K, L89IA
 PL3403155128 IDV, NFV207M46I, I84VL89VL10I, T12S, I13V, L19V, K20I, E35D, N37D, L63P, I66F, H69K, K70R, A71VA
Weber (2005)M50457M50457AY677433NFV94  L10I, T12S, I13V, K14KR, I15IV, K20I, E35D, M36I, N37S, R41K, K45R, H69K, A71V, L89TA
 F78596F78596AY677480IDV18  L10I, I13V, I15L, K20I, E35D, M36I, L63S, H69K, L89MA
 89M262689M2626AY677414SQV, NFV, RTV261I54V, L90MF53L, L89VL10I, I13V, K14R, K20I, E35D, M36I, N37E, R41K, R57K, H69K, A71V, T74SA
Baxter (2006)48-33163316-30818DQ878217PINAI54A, V82F L10I, T12TK, I13V, G16A, L19LV, K20I, E35N, M36I, R41K, D60E, L63P, H69K, T74S, V77I, L89MA
 48-41534153-30326DQ878387PINAM46I, I54L, L76V, I84VL10FI13V, G16E, K20I, L33L_L, E35D, M36I, R57K, Q61R, L63T, H69K, L89I, T91TSA
 48-50215021-30606DQ878555PINAI54V, V82F, I84IV, L90ML33F, F53LL10I, V11L, I13V, I15V, G16E, L19P, K20I, E35N, M36I, K45V, L63T, H69K, L89MA
 48-50315031-30421DQ878557PINAM46I, I54V, V82AG73SI13V, I15V, K20I, E35D, M36I, Q61H, L63D, H69K, A71V, L89TA
Seyler (2007)265CS_265 IDV66  L10V, I13V, L19P, K20I, M36I, R41K, K43R, L63LP, H69K, L89MA
 547CS_547 NFV268 G48GR, V82VDI13V, K14R, G16GR, K20I, M36IT, R41K, L63P, H69K, L89MA
Koyalta (2009)17TCHAD-17FJ688177IDV26M46I, I84V L10I, I13V, K14R, I15V, K20I, M36I, R41K, R57K, L63P, I66F, H69N, I72V, L89IA
 33TCHAD-33FJ688184IDV26  L10I, I13V, G16A, K20I, E35D, M36I, R41K, H69Q, L89MA
Charpentier (2011)32CP 001-144 Unknown, LPVNA  I13V, K14R, G17E, K20I, E34K, M36I, N37D, P39M, L63T, I64M, H69K, K70KR, I72T, L89MA
Charpentier (2011)CR-50CR-50FJ688256PINAM46IL10FK20I, E35D, M36I, N37D, R41K, I62IV, L63T, H69K, T74A, V77VI, I85IV, L89M, I93LA
 CR-13CR-13FJ688219PINAM46IL10F, L89VI13V, K20I, M36I, R41K, L63LP, H69K, I93MA
Jones (2012)178278178278JN670478PINAI54V, V82VA, L90LML10F, F53LI13V, K20I, E35D, M36I, N37D, R41K, I62V, L63V, H69K, K70R, T74A, L89M, T91VA
 184144184144JN670673PINAM46I, I50IL, I54AV, V82AL24I, L33F, Q58EL10I, T12N, I13V, G16GE, K20I, E35N, M36I, N37E, R41K, R57K, D60E, Q61N, L63T, I72T, L89MA
 199883199883JN671186PINAM46I, I54V, V82A, L90MN88DL10I, I13V, I15V, L19I, K20I, E35D, M36I, N37K, R41K, K45R, K55R, R57K, Q61N, L63P, C67F, A71T, I72EA
Kouri (2012)CU2041-09CU2041-09JQ585335PINAM46I, I54VL33I, G73SI13V, K14R, K20I, E35D, M36I, H69K, A71V, T74S, V75I, L89TA
 CU1315-09CU1315-09JQ585290PINAI54V, L90MF53L, L89VI13V, K14R, K20I, E35D, M36I, N37D, R41K, K45R, L63P, C67CY, H69K, A71IA
 CU75-11CU75-11JQ585492PINA  I13V, K14R, K20I, E35D, M36I, R41K, I64VA
 CU727-09CU727-09JQ585262PINAG48V, I54V, V82AF53LL10I, I13V, I15V, K20I, E35D, M36I, R41K, I64M, H69K, T74S, L89MA
 CU376-10CU376-10JQ585390PINAG48V, I54V, V82A L10V, T12I, I13V, K20I, E35D, M36I, N37DE, R41K, H69K, T74S, L89IA
 CU1908-09CU1908-09JQ585320PINAM46I, I54V, V82F, L90ML33F, T74PK20I, E35N, M36I, R41K, K43R, F53Y, R57K, I62V, L63P, H69K, I85V, R87RK, L89MA
Reynolds (2012)J7227J0722-2JN652210LPV   I13V, K20I, A22AV, E35N, M36I, R41K, H69K, V77I, L89MA
Rawizza (2013)LM3929LM3929KF241482LPV M46I, I47V, I54V, V82AF53L, Q58EL10I, I13V, K14R, I15V, K20I, L33L_L, E35G, M36I, R41K, K55R, L63T, I64M, L89MA
 LN5329LN5329KF241490LPV   I13IMV, G17E, K20I, M36I_V, P39AS, L63T, I64L, H69K, L89MA
Thiam (2013)2841-HALD2841-HALDJN673708LPV M46I, L76V, I84VV11I, L89VL10I, I13V, L19P, K20I, E35D, M36I, R41K, I62V, H69K, K70R, A71V, I72IR, P79AS, T91TS, Q92QKA
Grossman (2014)5959KC213684NFV, LPV52 V11CFISW6RS, Q7D, R8T, L10LH, I13V, K20I, E35D, M36I, R41K, H69K, L89M, Q92L, I93L, T96HA