<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype A
Gene PR
Mutation I13V
Rx >= 1 PI
IncludeMixtures No
References 53
Patients 269
Isolates 300
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Gonzales (2001)CA6428CA16183AF331690NFV41  I13V, K14R, I15V, E35D, M36I, R41K, L63M, H69K, L89MA
Weidle (2001)PW_UG4393PW_UG4393AF358747RTV51  I13V, K14R, E35D, M36I, R41K, H69K, L89MA
 PW_UG4399PW_UG4399a RTV69V82AL33FL10V, I13V, K20R, E35D, M36I, R41K, R57K, C67Y, H69K, L89MA
 PW_UG463PW_UG463a IDV13  I13V, E35D, M36I, R41K, L63Q, H69K, L89MA
 PW_UG471PW_UG471aAY900678SQV13  I13V, G16E, K20R, E35D, M36I, R41K, R57K, H69K, K70R, L89MA
 PW_UG473PW_UG473AF358758RTV40  I13V, K20I, E35D, M36I, R41K, H69K, L89MA
 PW_56PW_56AY900821SQV, IDV61 L89MVI13V, K14R, K20I, E35D, M36I, R41K, I62IV, H69K, T74TSA
Yahi (2001)NY_M29M29AY010392IDV M46I, I54V, V82F L10I, I13V, I15V, K20KI, E35D, M36I, R41K, D60E, I62IV, H69Q, L89IA
 NY_M31M31AY010395NFV L90M I13V, K14R, I15V, K20T, E35D, M36I, R41K, K45KR, H69K, L89IMA
 NY_M71M71AY010433IDV   L10V, I13V, K14R, G16E, E35D, M36I, R41K, R57K, H69K, L89MA
 NY_M72M72AY010434IDV M46MI, I84V I13V, K20I, E35D, M36I, R41K, L63P, H69K, A71V, L89TA
 NY_M73M73AY010435IDV   L10V, I13V, K14R, G16E, K20KI, E35D, M36I, R41K, R57K, H69K, T74TA, L89MA
Gibb (2002)DMG102102_w51 NFV52 V32LI13V, E35D, M36I, R41K, K45R, R57K, L63P, H69K, L89MA
 DMG106106_w41 NFV41M46LN83DI13V, G16A, K20R, A22V, E35D, M36I, R41K, R57K, I64IV, H69K, L89MA
  106_w43 NFV43  I13V, K14R, E35D, M36I, R41K, R57K, H69K, L89MA
 DMG1616_w16 NFV15  I13V, K14R, E35D, M36I, N37D, R41K, K45R, R57K, H69K, L89MA
  16_w32 NFV30  I13V, K14R, E35D, M36I, N37D, R41K, K45R, R57K, H69K, L89MA
 DMG6565_w9 NFV9  I13V, G16A, K20R, E35D, M36I, R41K, R57K, H69K, A71AV, L89MA
 DMG6868_w27 NFV27M46MI I13V, G16A, K20R, E35D, M36I, R41K, R57K, H69K, L89MA
  68_w30 NFV30  I13V, G16A, K20R, E35D, M36I, R41K, R57K, H69K, L89MA
 DMG7070_w27 NFV27  I13V, G16E, E35D, M36I, R41K, L63V, G68GE, H69K, L89M, T91V, I93LA
 DMG7777_w19 NFV14  I13V, E35D, M36I, R41K, R57K, H69K, L89MA
  77_w42 NFV37  I13V, E35D, M36I, R41K, R57K, H69K, L89MA
  77_w67 NFV59  I13V, E35D, M36I, R41K, R57K, H69K, L89MA
 DMG8686_w71 NFV54  I13V, K14R, E35D, M36I, R41K, R57K, H69K, L89MA
 DMG9898_w29 NFV29  I13V, E35D, M36I, R41K, K45R, R57K, L63P, H69K, L89MA
Papa (2002)46GR46AF385363RTV78  I13V, K14R, E35D, M36I, N37D, R41K, I64M, H69K, L89MA
 64GR64AF385365RTV I54V, V82AL33FI13V, E35D, M36I, N37D, R41K, H69KR, L89MA
 16GR16AF385360IDV M46I, N88SK43T, L89VI13V, K20I, E35DG, M36I, N37D, R41K, I62IV, H69K, A71TA
Holguin (2003)SP_LP17SP_LP17AF455614PINA  L10I, I13V, K14R, E35D, M36I, R41K, H69K, L89MA
 SP_LP5SP_LP5AF455604PINA  L10I, I13V, K14R, E35D, M36I, R41K, L63V, H69K, L89MA
Shafer (2003)A384_09830983bEF548169NFV43  L10V, I13V, K20T, E35D, M36I, R41K, R57K, H69K, L89M, I93MA
Vergne (2003)VL00SN69HPD00SN69AJ583752IDV I84VG73SI13V, E35D, M36I, R41K, K45R, R57K, L63P, H69K, A71V, L89TA
Weber (2003)3MIRIS3M-24AY140812SQV, RTV22  I13V, E35D, M36I, R41K, H69K, L89MA
 5WIRIS5W-48AY140814IDV48  L5F, I13V, E35D, M36I, R41K, R57K, H69K, L89MA
 SIIRIS6I-48AY140815SQV, RTV52  I13V, E35D, M36I, R41K, R57K, H69K, V77I, L89MA
Gomez-Carrillo (2004)103396103396AY365678PINAI54V I13V, K20I, E35D, M36I, N37D, R41K, I62V, L63V, I66F, G68E, H69R, L89M, T91VA
 104575104575AY365707PINA  I13V, E35D, M36I, N37D, R41K, L63V, H69K, K70R, L89IM, T91VA
 111780111780AY365851PINA  I13V, E35D, M36I, N37D, R41K, L63V, H69K, K70R, L89M, T91VA
Grossman (2004)IL351IL351AY529589NFV226M46IQ58QEI13V, K14KR, K20KR, E35ED, M36I, N37ND, R41K, H69K, L89I, I93LA
Montes (2004)MB_patSAA00_SAA713AJ577989NFV, SQV21  L10I, I13V, I15V, E35D, M36I, R41K, H69K, L89MA
  01_SAA704AJ577990NFV, SQV21  L10I, I13V, I15V, E35D, M36I, R41K, H69K, L89MA
 MB_patBES00_BES703AJ577738SQV104  I13V, I15S, G16R, G17R, E35D, M36I, R41K, R57K, H69K, L89MA
  02_BES706AJ577740SQV, RTV108  I13V, K14R, I15V, E35D, M36I, R41K, R57K, H69K, L89M, G94AA
 MB_patELA02_ELA701AJ577884SQV, RTV, Unknown>25  I13V, G16E, E35D, M36I, R41K, L63A, G68E, H69K, K70R, L89I, T91V, I93LA
 MB_patSAN01_SANC718AJ577992SQV, IDV, RTV143M46I, I84V, L90MG73S, L89VL10V, I13V, G16A, K20R, E35D, M36I, N37E, R41K, D60E, I62V, L63P, H69KA
 MB_patMUZ00_MUZ714AJ577959NFV18 L10FI13V, E35D, M36I, R41K, R57K, H69K, L89IA
 MB_patROI00_ROI705AJ577983SQV, RTV, IDV193  I13V, G16E, K20R, M36I, R41K, L63N, H69K, K70R, L89I, T91V, I93LA
 MB_patMAK01_MAK707AJ577938SQV, RTV, NFV182I54V, I84V, L90MV32G, F53LL10I, I13V, K14R, G17E, K20I, E35D, M36I, R41K, L63P, H69K, T74A, L89MA
  01_MAK719AJ577939SQV, RTV, NFV, LPV203M46I, I54V, I84VF53LL10V, I13V, K14R, G17E, K20I, E35D, M36I, R41K, H69K, T74A, L89MA
  02_MAK737AJ577940SQV, RTV, NFV, LPV225M46I, I47V, I54V, I84VF53LL10I, I13V, K14R, G17E, K20I, E35D, M36I, N37E, R41K, H69K, T74A, L89MA
Chantratita (2005)14-006814-0068DQ130454PINA  W6R, L10V, I13V, G16E, E35D, M36I, R41K, K43R, L63S, H69K, L89MA
 14-010214-0102DQ130472PINAM46LG48R, N83D, L89VW6R, I13V, L33V, E35D, M36V, N37D, R41K, K55R, I62V, L63P, H69KA
 G586G586DQ130150PINAV82AQ58EW6R, L10I, I13V, G16E, K20I, E35D, M36I, R41K, L63T, H69K, L89MA
 G589G589DQ130152PINA  L10V, I13V, G16A, L19M, K20I, E35N, M36I, N37D, R41K, D60E, Q61E, L63P, H69K, L89M, I93LA
 G738G738DQ130229PINA  L10I, I13V, G16E, K20R, E35D, M36I, R41K, L63T, G68E, H69K, K70R, I72V, L89M, T91VA
 NP266NP266DQ130348PINA  L10I, I13V, G16E, K20R, E35D, M36I, R41K, C67G, H69K, K70R, L89MA
 NP294NP294DQ130374PINAM46II50NL10N, I13V, G16E, G17E, E35D, M36I, R41K, K43R, I62V, L63S, H69K, L89MA
 NP304NP304DQ130384PINAG48V, I54T, V82A L10V, T12P, I13V, G16A, K20I, E35N, M36I, R41K, R57K, L63P, H69K, T74S, L89MA
 NP313NP313DQ130391PINA  L10V, I13V, K14N, G16E, K20R, E35D, M36I, R41K, K43R, L63T, H69K, K70R, L89MA
Hsu (2005)BAA161436BAA161436AY870234SQV, RTV26 L33FL10I, I13V, R41K, I62V, L63I, H69K, K70R, V82I, L89M, F99LA
Non-B Workgroup (2005)UK847bUK847bAY900783NFV, LPV   I13V, K14R, E35D, M36I, R41K, R57K, L63P, H69K, L89MA
 UK1436UK1436AY900801SQV, RTV, NFV123 N83DI13V, K14R, K20R, A22V, E35D, M36I, R41K, R57K, H69K, L89I, T91AA
 UK1516UK1516 PI, LPVNAI54L L10I, I13V, G16E, K20T, E35D, M36I, R41K, R57K, L63T, H69K, T74S, V82VI, I85V, L89MA
 UK2149UK2149AY900859Unknown, LPVNAM46I, L76V, I84VL33I, N83DL10I, I13V, A22V, E35D, M36I, N37D, R41K, K45R, R57K, L63P, A71V, L89IA
 PL972860099AY901076IDV, RTV, ATV I54V, V82AL33I, F53L, N83DL10Y, I13V, G16E, K20R, A22AV, E35DN, M36I, N37ND, R41RK, L63T, H69K, T74S, L89M, T91AA
 PL4018468632AY901088ATV22  L10IV, T12I, I13V, K14R, G16E, E35D, M36I, R41K, R57RK, H69K, L89MA
 TK1001TK1001 IDV129  L10I, I13V, K14R, E35D, M36I, R41K, R57K, H69K, L89MA
  TK1001a IDV179V82A L10I, I13V, K14R, E35D, M36I, R41K, R57K, H69K, L89IA
 TK1005TK1005 RTV, IDV, NFV201  I13V, E35D, M36I, N37ND, R41K, R57RK, L63LI, H69K, L89MA
 TK1010TK1010b IDV, Unknown>229 L10FT12I, I13V, G16E, E35D, M36I, R41K, R57K, I62V, L63H, H69K, K70R, L89MA
 TK1014TK1014 RTV, SQV, NFV, IDV246M46I, I84IVL24LIL10LV, I13V, K20I, E35D, M36I, R41K, L63P, H69K, T74S, T80TA, V82X, L89IMA
 TK1025TK1025 IDV, LPV180  I13V, I15V, E35D, M36I, R41K, K45R, R57K, Q61E, I64M, H69K, K70Q, I72IV, L89MA
 TK1030TK1030 SQV, RTV, IDV146  L10I, I13V, G16E, E35D, M36I, R41K, R57K, L63S, H69K, L89MA
  TK1030a SQV, RTV, IDV305  L10V, I13V, G16GE, E35D, M36I, R41K, R57K, L63PS, H69K, L89MA
 TK2002TK2002 IDV, RTV273M46MI, V82ATL33I, N83DL10LI, I13V, K14R, A22AV, E35D, M36I, R41K, R57K, H69K, L89IMA
 TK2007TK2007 SQV, RTV69  I13V, E35D, M36I, N37ND, R41K, K45R, R57K, H69K, L89MA
 TK2012TK2012 RTV, IDV, SQV186I54V, L90M L10V, I13V, K14R, I15V, K20R, E35D, M36I, R41K, R57K, I62V, H69K, T74S, L89IA
 TK2021TK2021 NFV88  I13V, I15V, E35D, M36I, R41K, R57RK, H69K, K70R, L89MA
 TK2022TK2022 SQV, RTV12  L10X, I13V, I15IV, L19LI, E35D, M36I, R41K, R57K, L63X, H69K, L89MA
 TK2027TK2027 IDV, RTV90  I13V, E35D, M36I, R41K, K45R, R57K, H69K, L89MA
 TK2029TK2029 IDV39  L10I, I13V, K14R, G16GE, E35D, M36I, R41K, K45R, R57K, L63P, H69K, V77I, L89MA
 TK3001TK3001 SQV90L90ML33FI13V, K14R, K20T, M36I, R41K, K43N, R57K, H69K, V82I, I85V, L89MA
 TK3017TK3017 RTV174L90M L10V, I13V, G16E, K20R, E35D, M36I, R41K, L63T, H69K, L89MA
  TK3017a RTV222L90M L10V, I13V, G16E, K20R, E35D, M36I, P39PS, R41K, L63T, H69K, L89MA
  TK3017b RTV230L90M L10V, I13V, G16E, K20R, E35D, M36I, P39PS, R41K, L63T, H69K, L89MA
  TK3017c RTV249L90M L10V, I13V, G16E, K20R, E35D, M36I, P39PS, R41K, L63T, H69K, L89MA
 TK3029TK3029 SQV, NFV149L90M L10V, I13V, K20T, E35D, M36I, R41K, H69K, T74S, L89IA
  TK3029a SQV, NFV, LPV207  I13V, E35D, M36I, R41K, H69K, L89MA
 TK3030TK3030 SQV, NFV250  I13V, E35D, M36I, N37NT, R41K, K45R, R57K, H69K, L89M, I93IMA
 TK3033TK3033 NFV1  I13V, I15IV, E35D, M36I, R41K, R57K, H69K, L89MA
  TK3033a NFV1  I13V, K20KR, E35D, M36I, R41K, R57K, H69K, L89MA
 TK4003TK4003 NFV116 N83DL10V, I13V, K14R, G16E, E35D, M36I, R41K, K45R, R57K, L63T, H69K, K70R, L89M, I93LA
  TK4003a NFV215I54VL33I, N83DL10V, I13V, K14R, G16E, A22V, E35D, M36I, R41K, K45R, L63T, H69R, K70R, L89IA
 TK4006TK4006 NFV83N88SL10FI13V, I15V, K20I, E35N, M36I, R41K, K45R, R57Q, H69K, L89IA
 TK4007TK4007 NFV178M46I I13V, E35D, M36I, R41K, R57K, L63P, H69K, A71AV, L89TA
 TK4010TK4010 SQV, RTV, NFV54L90M I13V, I15V, K20T, E35D, M36I, R41K, R57K, L63P, H69K, V77I, L89MA
 TK4013TK4013 SQV, RTV, NFV213  I13V, K14R, I15V, E35D, M36I, R41K, R57K, H69K, L89MA
 TK5002TK5002 NFV189N88SL10FI13V, K14R, I15V, K20T, E35D, M36I, R41K, K45R, R57K, H69K, L89IA
 TK5005TK5005 SQV, IDV, RTV, NFV, LPV180G48V, I54T, V82A, L90M L10I, I13V, K14R, G17D, K20R, E34N, E35D, M36I, R41K, R57K, D60E, I62V, L63P, H69K, A71V, L89IA
  TK5005a SQV, IDV, RTV, NFV, LPV196G48V, I54T, L90M L10I, I13V, K14R, G17D, K20R, E34N, E35D, M36I, R41K, R57K, D60E, I62V, L63P, H69K, A71IV, L89I, I93IMA
 TK5008TK5008 IDV93  I13V, G16E, K20R, E35D, M36I, R41K, R57K, H69K, K70R, L89MA
 TK5012TK5012 IDV54  L10I, I13V, K14R, G16E, K20R, E35D, M36I, R41K, L63T, H69K, L89MA
  TK5012a IDV, LPV152  L10I, I13V, K14KR, G16E, K20R, E35D, M36I, R41K, L63T, H69K, L89MA
  TK5012b IDV, LPV191  L10IV, I13V, K14KR, G16E, K20R, E35D, M36I, R41K, L63T, H69K, L89MA
  TK5012c IDV, LPV215  L10I, I13V, K14KR, G16E, K20R, D25DG, E35D, M36I, R41K, L63ST, H69K, L89MA
 PL3403155128 IDV, NFV207M46I, I84VL89VL10I, T12S, I13V, L19V, K20I, E35D, N37D, L63P, I66F, H69K, K70R, A71VA
Weber (2005)F45753F45753AY677422SQV, NFV258  L10I, I13V, G16E, K20R, E35D, M36I, P39S, R41K, H69K, L89MA
 M74228M74228AY677423NFV75  L10V, I13V, K14R, G16E, K20R, E35D, M36I, N37D, R41K, H69K, I72T, L89I, Q92KA
 M76115M76115AY677424LPV19  I13V, I15V, E35D, M36I, N37E, R41K, K45R, R57K, H69K, L89MA
 M49551M49551AY677385RTV96  T4TP, I13V, G16E, E35D, M36I, R41K, H69K, L89MA
 M50457M50457AY677433NFV94  L10I, T12S, I13V, K14KR, I15IV, K20I, E35D, M36I, N37S, R41K, K45R, H69K, A71V, L89TA
 F46097F46097AY677388NFV, SQV, RTV148  T4TP, I13V, K14R, Q18QH, E35D, M36I, R41K, R57K, L63P, H69K, L89MA
 F51354F51354AY677444SQV, NFV115  L10V, I13V, K14R, G16E, K20T, E35D, M36I, R41K, R57K, L63T, H69K, I72T, T74TA, L89MA
 M36781M36781-2AY714402Unknown, LPV>8  I13V, G16E, E35D, M36I, R41K, K45R, R57K, H69K, I72K, L89MA
 F57352F57352AY677463NFV145L90LM L10LV, I13V, I15V, K20KT, E35D, M36I, R41K, K45KQ, I62IV, H69K, T74TK, L89IMA
 M41971M41971AY677401IDV, NFV, LPV181I54V, V82AL10F, L33IT4TS, I13V, G16E, L19LI, K20R, E35D, M36I, N37D, R41K, K45V, K55T, R57K, L63H, H69K, K70R, L89M, T91TSA
 F87084F87084AY677406IDV28  L10I, I13V, K14R, G16E, E35D, M36I, R41K, R57K, L63V, H69K, L89MA
 F73291F73291AY677477NFV195M46LL33I, N83DL10V, I13V, A22V, E35D, M36I, R41K, I62V, L63PS, H69K, T74S, L89I, I93LA
 F78596F78596AY677480IDV18  L10I, I13V, I15L, K20I, E35D, M36I, L63S, H69K, L89MA
 M47502M47502AY677409NFV51N88NS L10I, I13V, K20KT, E35ED, M36I, R41K, L63T, I64IV, H69K, L89MA
 M41984M41984AY677484IDV139 L33FI13V, K14R, E35D, M36I, R41K, K43KR, R57K, H69K, L89MA
 01M612201M6122AY677413NFV224N88SL10FI13V, K20I, E35D, M36I, R41K, H69K, L89MA
 89M262689M2626AY677414SQV, NFV, RTV261I54V, L90MF53L, L89VL10I, I13V, K14R, K20I, E35D, M36I, N37E, R41K, R57K, H69K, A71V, T74SA
 F56706F56706AY714473SQV, RTV153  T12A, I13V, E35D, M36I, N37D, R41K, R57K, D60E, H69K, L89MA
Baxter (2006)12-20242024-30709DQ876698PINAM46L, I54VL33F, N83DL10V, I13V, K14R, E35D, M36IL, N37ND, R41K, R57K, H69Q, L89MA
 12-21202120-30715DQ876783PINAM46I, I47V, L90ML10F, L33I, F53L, G73GS, N88G, L89VI13V, K14R, K20T, E35D, M36I, R41K, R57K, I62V, L63P, H69K, A71IA
  2120-40510DQ876754PI, RTV, TPV>43M46I, I47V, L90ML10F, L33I, F53L, G73S, N88G, L89VI13V, K14R, K20T, E35D, M36I, R41K, R57K, I62V, L63P, H69K, A71IA
 48-12021202-30702DQ877746PINAI54V, V82A, L90ML33F, N83DI13V, G16E, K20R, E35D, M36I, N37D, R41K, R57RK, L63N, H69K, K70R, L89I, T91V, I93LA
 48-12041204-30709DQ877748PINAM46I, G48Q, I54T, V82FL33F, Q58E, N83DL10V, I13V, G16E, E35D, M36L, P39S, R57K, I62V, L63V, H69K, T74A, L89MA
 48-12531253-30605DQ877778PINA  L10V, T12TP, I13V, K14R, G16E, K20R, E35D, M36I, R41K, R57RK, Q61QE, I62IV, L63CS, H69K, L89MA
 48-12541254-30617DQ877779PINAG48VL33F, N83DL10LI, I13V, E35D, M36V, N37NS, P39T, R41K, R57K, L63S, H69K, L89MA
  1254-40601DQ877780PI, RTV, TPV>50 L33FT12A, I13V, E35D, M36IV, P39AT, R41K, R57K, L63S, H69K, L89MA
 48-30453045-30317DQ877957PINAG48V, I54S, V82AL33F, Q58E, N83DL10V, I13V, K14R, I15V, M36L, R41RK, D60DE, I62IV, L63P, H69K, I85V, L89I, T91TSA
 48-32643264-30703DQ878168PINAM46I, I54V, I84V, L90ML10F, L89VI13V, K14KR, G16E, K20L, M36I, D60E, Q61H, L63R, I66V, H69K, K70R, A71T, P79A, I93L, C95FA
  3264-40322DQ878169PI, RTV, TPV>38M46I, I54V, I84V, L90ML10F, L89VI13V, G16E, K20L, L23M, M36I, D60E, Q61H, L63R, I66V, H69K, K70R, A71T, P79A, I93L, C95VA
 48-32933293-30722DQ878198PINAM46I, I54V, L76V, V82A, L90MV11IL10I, T12E, I13V, I15V, K20I, E35N, M36I, N37D, R41K, I62V, L63P, H69K, K70KR, A71V, T74S, L89I, T91SA
 48-33163316-30818DQ878217PINAI54A, V82F L10I, T12TK, I13V, G16A, L19LV, K20I, E35N, M36I, R41K, D60E, L63P, H69K, T74S, V77I, L89MA
 48-33333333-30929DQ878227PINAM46I, I47V, I54V, I84VL33F, G73SL10V, I13V, I15V, K20T, E35D, M36I, P39S, R41K, Q61D, I62V, L63P, I66F, H69K, T74S, L89TA
 48-41534153-30326DQ878387PINAM46I, I54L, L76V, I84VL10FI13V, G16E, K20I, L33L_L, E35D, M36I, R57K, Q61R, L63T, H69K, L89I, T91TSA
 48-41864186-30408DQ878420PINAI54V, V82AL24I, L33I, Q58E, N83DL10I, I13V, G16E, K20R, A22V, E35D, M36I, N37D, R41K, L63T, H69K, I72V, T74A, L89M, T91V, I93LA
 48-42024202-30804DQ878434PINA  L10V, I13V, K14KR, I15V, G16E, E35D, M36I, R41K, K45R, L63T, H69KA
 48-50055005-30422DQ878538PINAI54IATV, V82VA, L90LML33LFL10LI, I13V, K14KR, L19LI, K20KR, E35D, M36I, R41K, K45R, R57K, L63P, H69K, L89IMA
 48-50215021-30606DQ878555PINAI54V, V82F, I84IV, L90ML33F, F53LL10I, V11L, I13V, I15V, G16E, L19P, K20I, E35N, M36I, K45V, L63T, H69K, L89MA
 48-50315031-30421DQ878557PINAM46I, I54V, V82AG73SI13V, I15V, K20I, E35D, M36I, Q61H, L63D, H69K, A71V, L89TA
 48-50325032-30421DQ878558PINAI54V, L90ML10F, L33I, L89VI13V, E35D, M36I, R41K, R57K, I62IV, L63LP, H69KA
 48-50355035-30421DQ878561PINA  T12P, I13V, K14R, E35D, M36I, R41K, K45R, R57K, L63P, H69K, K70R, L89MA
 48-50735073-30807DQ878583PINAI54V, V82A, L90ML33F, T74TPT4TS, I13V, K20R, E35D, M36I, N37D, R41K, F53I, I62IV, I66IF, H69R, L89IA
 48-50745074-30807DQ878584PINAG48V, I54S, V82A, L90MK43TL10I, I13V, K20I, E34K, E35D, M36I, N37D, R41K, I62V, L63P, H69K, A71V, T74S, L89IA
 48-50775077-30903DQ878587PINAM46L, I54V, V82AL24I, L33F, F53L, T74PL10I, I13V, L19I, K20R, E35D, M36I, N37D, Q61R, L63P, H69K, L89MA
Laurent (2006)CK2-7502CM-75AM279446IDV39  L10V, I13V, I15V, E35D, M36I, R41K, R57K, D60E, H69K, L89MA
 CK22-3503CM2-35AM279456IDV74I54IV, V82AL33LIL10I, I13V, E35D, M36I, R41K, K45R, L63P, H69K, L89TA
Seyler (2007)293CS_293 NFV150N88NSV11VIL10M, T12TA, I13V, K14R, G16E, K20KI, E35D, M36I, R41K, K43KR, H69K, I72IR, L89MTA
 483CS_483 NFV162  L10V, I13V, G16GE, E35D, M36I, R41K, H69K, K70R, L89MA
von Wyl (2007)791477616EF449916PINA  I13V, E35D, M36I, R41K, R57K, H69K, L89MA
 13662529EF449971PINA  I13V, I15V, E35D, M36I, R41K, R57K, H69K, T74S, L89MA
Gody (2008)Pt047Pt047 IDV   L10V, I13V, G16E, E35D, M36I, N37D, L63AS, H69K, I72V, L89MA
Rosen-Zvi (2008)3901p39-1 RTV, IDV, LPV138  I13V, E35D, M36I, R41K, K45R, L63LP, H69K, L89MA
Sylla (2008)A2868A2868_C1EF525663IDV   L10I, I13V, G16E, K20R, E35D, M36I, R41K, H69K, K70R, I72R, L89MA
Koyalta (2009)33TCHAD-33FJ688184IDV26  L10I, I13V, G16A, K20I, E35D, M36I, R41K, H69Q, L89MA
Steegen (2009)BV114BV114-1EU872122LPV4  I13V, G16E, K20R, E35D, M36I, R41K, Q61H, L63T, G68E, H69K, K70R, V82I, L89M, T91V, I93LA
Thomson (2009)SP_B_008RU_SP_B_008FJ009786LPV   L10LI, I13V, K14R, M36I, R41K, H69K, L89MA
 SP_B_028RU_SP_B_028FJ009793NFV   L10LI, I13V, K14R, E35D, M36I, R41K, R57K, H69K, L89M, I93ILA
 SP_B_051RU_SP_B_051FJ009809DRV4  I13V, I15V, E35D, M36I, R41K, H69K, V77I, L89M, I93LA
Dau (2010)10412A10412AGU582000PINA  L10V, I13V, E35D, M36I, R41K, L63V, I64V, H69KA
 11741A11741AGU582052PINAN88SL10F, L89VI13V, K20T, E35D, M36I, R41K, I62V, L63P, H69K, T74SA
Knops (2010)ID1585ID1585-GT2GU271169SQV, NFV, RTV, APV, LPV64I54V, L76V, V82M, L90ML33F, Q58E, G73S, L89VL10V, T12V, I13V, I15V, K20R, E35D, M36I, N37E, R57K, I62IV, L63P, H69KA
Charpentier (2011)4CP001-045 Unknown, IDVNAL90ML33IL10V, I13V, L19F, K20T, E35D, M36I, R41K, R57K, L63P, H69K, T74S, L89IA
Charpentier (2011)CR-43CR-43FJ688249PINAM46I, V82FL10FI13V, K14R, I15V, K20I, E35D, M36I, N37D, R41K, L63T, H69K, T74TA, L89M, I93MA
 CR-13CR-13FJ688219PINAM46IL10F, L89VI13V, K20I, M36I, R41K, L63LP, H69K, I93MA
Barber (2012)5085750857JQ361664LPV M46I, L76V, I84V L10I, I13V, G16E, M36I, R41K, L63T, H69K, L89MA
 4882648826JQ361679LPV V32I, M46I, I47AL10F, L33I, L89VI13V, K20R, E35D, M36I, R41K, R57K, I62V, H69K, K70R, T74SA
Dvali (2012)R045R045GQ268451NFV M46MI I13V, K14R, G16E, E35D, M36I, R41K, E65EK, H69K, I72IT, L89M, I93ILA
El Annaz (2012)929929.PRJN185233PINA  L10V, I13V, K14R, G16E, E35D, M36I, R41K, H69K, L89M, I93ILA
 13281328.PRJN185236PINA  L10I, I13V, E21Q, E35D, M36I, R41K, H69K, L89MA
 18771877.PRJN185240PINA  L10V, I13V, I15V, M36I, L63P, H69K, L89MA
 52185218.PRJN185254IDV52  L10V, I13V, K14R, G16E, E35D, M36I, R41K, H69K, L89MA
Jones (2012)160444160444JN669977PINAI54IVL10F, F53FLI13V, E35D, M36I, N37D, R41K, L63V, H69K, K70R, T74A, L89M, T91VA
 178278178278JN670478PINAI54V, V82VA, L90LML10F, F53LI13V, K20I, E35D, M36I, N37D, R41K, I62V, L63V, H69K, K70R, T74A, L89M, T91VA
 203362203362JN671308PINA  L5LF, L10LP, I13V, G16E, E35D, M36I, R41K, L63V, H69K, L89M, T91VA
Kouri (2012)CU108-10CU108-10JQ585364PINAV32I, I54L, I84VL33F, K43T, F53LL10I, I13V, I15S, L19LI, K20R, E35D, M36I, R41K, D60E, Q61E, I62V, L63T, I64IV, H69K, A71AV, T74A, P79A, L89MA
 CU1-10CU1-10JQ585357PINA  P1R, W6G, P9H, I13V, I15V, G16E, K20R, E35D, M36I, R41K, R57K, L63A, E65D, H69K, K70R, L89MA
Mollan (2012)MK105MK105w24 RTV, ATV24  I13V, E35D, M36I, R41K, R57K, H69K, L89MA
 MK186MK186w26 RTV, ATV25  I13V, E35N, M36I, R41K, R57K, H69K, L89MA
Reynolds (2012)J7227J0722-2JN652210LPV   I13V, K20I, A22AV, E35N, M36I, R41K, H69K, V77I, L89MA
Avidor (2013)37_MT37_MTKC184372IDV   R8RH, I13V, K14R, E35D, M36I, N37ND, R41K, Q61QE, H69K, L89MA
 989_MT989_MTKC184397NFV L90ML10LFI13V, K20T, E35D, M36I, R41K, H69K, A71AV, T74S, L89I, I93LA
 200200 IDV   R8T, P9T, I13V, G17E, E35D, M36I, R41K, R57K, D60DE, H69K, L89MA
 196196 APV M46I, I84VL10FI, L33FI13V, K20R, L24LV, E35D, M36I, N37D, R41K, K45R, R57K, I62IV, H69K, L89M, I93VA
Inzaule (2013)266266JQ914054NFV   I13V, K14R, G16E, E35D, M36I, N37E, P39T, R41K, H69K, L89MA
 357357JQ914076LPV   I13V, K14R, E35D, M36I, N37D, R41K, R57K, D60E, H69K, L89MA
 410410JQ914067LPV   I13V, K14R, E35D, M36I, R41K, R57K, L63P, H69K, L89MA
 472472JQ914071LPV   I13V, G16E, K20R, E35D, M36I, R41K, R57K, L63T, E65D, H69K, L89MA
  472JQ914073LPV   I13V, G16E, K20R, E35D, M36I, R41K, R57K, L63T, E65D, H69K, L89MA
 475475JQ914089NFV   I13V, E35D, M36I, R41K, H69K, L89MA
 496496JQ914087NFV   I13V, E35D, M36I, N37D, R41K, R57K, L63A, H69K, L89MA
 433433JQ914055NFV   I13V, I15V, E35D, M36I, N37E, R41K, R57K, H69K, L89MA
Kim (2013)Tx22307KC120891IDV, ATV V32I, M46I, I47V, I84VL33LF, F53L, L89VL10Y, T12V, I13V, G16E, K20M, E35D, M36I, N37ND, R41K, R57K, H69K, A71I, I72RA
Rawizza (2013)LM3929LM3929KF241482LPV M46I, I47V, I54V, V82AF53L, Q58EL10I, I13V, K14R, I15V, K20I, L33L_L, E35G, M36I, R41K, K55R, L63T, I64M, L89MA
Van Zyl (2013)O11961593KC423255LPV52 L33FI13V, K20R, M36I, R41K, D60E, Q61E, H69K, L89M, I93VA
 O4631671KC423313LPV26  L10I, I13V, G16E, K20R, E35D, M36I, R41K, R57K, E65D, H69K, I72V, L89MA
 O7211935KC423520LPV52  T12P, I13V, I15V, G16E, E35D, M36I, R41RK, D60DE, L63S, H69K, K70R, L89IM, T91V, I93LA
Acharya (2014)DGP185DGP185KJ185355RTV, ATV M46I, I54V, V82A, N88SL24I, L33F, Q58EL5I, L10V, I13V, I15V, E35D, M36I, N37E, R41K, R57K, D60E, H69K, A71V, L89MA
 DGP156DGP156KJ185326RTV, ATV   L10I, I13V, I15V, K20R, E35D, M36I, N37D, R41K, K45R, R57K, H69K, K70R, L89MA
 DGP152DGP152KJ185322RTV, ATV   L5I, L10I, I13V, I15V, E35D, M36I, N37E, R41K, R57K, D60E, H69K, L89MA
 DGP122DGP122KJ185292LPV   L10V, I13V, I15V, K20R, E35D, M36I, N37D, R41K, K45R, R57K, H69K, K70R, L89MA
 DGP112DGP112KJ185282RTV, ATV   L10V, I13V, I15V, K20R, E35D, M36I, N37D, R41K, K45R, R57K, H69K, K70R, L89MA
 DGP096DGP096KJ185266RTV, ATV V32ID30VL5I, I13V, I15V, E35D, M36I, N37E, R41K, R57K, D60E, H69K, T74S, L89MA
 DGP087DGP087KJ185257RTV, ATV   L5I, I13V, I15V, E35D, M36I, N37E, R41K, R57K, D60E, H69K, L89MA
 DGP029DGP029KJ185199LPV   I13V, L19I, E35D, M36I, N37D, R41K, R57K, H69K, K70R, L89MA
Grossman (2014)12211221KF134967LPV52  I13V, K14KR, I15V, E35D, M36I, N37D, R41K, Q61E, H69K, K70R, L89MA
 5959KC213684NFV, LPV52 V11CFISW6RS, Q7D, R8T, L10LH, I13V, K20I, E35D, M36I, R41K, H69K, L89M, Q92L, I93L, T96HA
 792792KC184392LPV52  I13V, E35D, M36I, R41K, H69K, T74S, L89M, I93LA
 18631863 LPV52  L10I, I13V, K14R, E35D, M36I, N37D, R41K, D60E, Q61E, L63V, H69K, L89M, I93LA
 421421 IDV, LPV52  L10M, I13V, K20KR, E35D, M36I, R41K, K43R, R57K, L63LIPT, H69K, L89MA
 948948 LPV52  I13V, E35D, M36I, R41K, L63T, H69K, V77I, L89M, I93LA
Kolomeets (2014)335335_474KJ870549SQV L90M I13V, K14R, E35D, M36I, R41K, L63Q, H69K, L89MA
 182182_327KJ870438LPV   L10I, I13V, K14R, G16E, E35D, M36I, R41K, L63T, E65D, H69K, L89MA
 430430_630KJ870658LPV   I13V, K14R, E21EK, E35D, M36I, R41K, H69K, V77I, R87RK, L89MA
 7676_88KJ870262LPV   L10LI, I13V, E35D, M36I, R41K, Q61E, L63T, E65D, H69K, T74S, L89M, I93LA
 226226_363KJ870469LPV   I13V, K14R, K20R, E35D, M36I, N37D, R41K, R57K, H69K, L89MA
 162162_192KJ870333LPV   I13V, E35D, M36I, R41K, L63P, H69K, V77I, L89MA
 442442_639KJ870664LPV   L10I, I13V, K14R, G16E, E35D, M36I, N37D, R41K, H69K, V77I, L89MA
 3737_591KJ870627LPV   L10IV, I13V, I15V, K20KI, E34EK, E35DN, M36I, N37D, R41K, K55KR, H69K, V77I, L89MA
 175175_272KJ870393PINAM46LL10FI13V, M36I, R41K, H69K, T74S, V77I, L89MA
 313313_414KJ870506LPV   L10I, I13V, K14R, G16E, E35D, M36I, R41K, H69K, V77I, L89MA
 205205_247KJ870373ATV   I13V, I15V, E35D, M36I, R41K, L63P, H69K, L89M, I93LA
 273273_442KJ870527LPV   L10I, I13V, K14KR, G16E, E35EDKN, M36I, R41K, I62V, H69K, T74S, V77I, L89MA
 137137_304KJ870418LPV   I13V, E35D, M36I, R41K, H69K, L89MA
 111111_357KJ870464LPV   I13V, K14KR, I15V, G16GAV, T31TA, E35D, M36I, R41K, H69K, V77I, L89M, I93LA
 143143_311KJ870425LPV   I13V, K14R, G16GE, E35D, M36I, R41K, H69K, V77I, L89I, I93LA
 7575_367KJ870472LPV   L10I, I13V, E35D, M36I, R41K, R57RK, Q61E, L63LIPT, I64IL, E65ED, H69K, V77VI, L89MA
 196196_346KJ870454LPV   I13V, E35D, M36I, R41K, R57RK, I66N, H69K, V77I, L89MA
 150150_135KJ870284LPV   I13V, K14R, E35D, M36I, R41K, H69K, L89M, I93LA
 265265_230KJ870364PINA  I13V, E35D, M36I, R41K, H69K, V77I, L89MA
 343343_521KJ870581LPV   I13V, K14R, G16E, K20I, E35DN, M36I, N37NDY, R41K, H69K, K70KR, V77I, L89MA
 399399_565KJ870611PINA  I13V, K14KR, E35D, M36I, R41K, H69K, V77I, L89MA
 441441_636KJ870661LPV   I13V, K14R, E35D, M36I, R41K, H69K, L89M, I93LA
 3333_328KJ870439APV   L10LI, I13V, K14KR, G16E, E35D, M36MI, R41K, H69K, V77I, L89IA
 3737_529KJ870586LPV   L10I, I13V, I15IV, E35D, M36I, N37D, R41K, H69K, V77I, L89MA
 2525_415KJ870507LPV   I13V, K14KR, G16GE, L19I, K20I, E35D, M36I, R41K, H69K, V77I, L89MA
  25_137KJ870286LPV   I13V, K14KR, L19LI, K20KI, E35D, M36I, R41K, H69K, V77I, L89MA
 189189_338KJ870448LPV   I3V, L10LI, I13V, I15IV, E35D, M36I, R41K, I62IV, H69K, V77I, L89MA
 110110_355KJ870462APV   L10I, I13V, K14R, G16E, E35D, M36I, R41K, H69K, L89MA
 316316_419KJ870510APV  L33F, T74PI13V, K14R, E34EG, E35D, M36I, R41K, R57RK, D60DE, I62IT, L63LI, H69K, V77I, L89M, I93LA
 191191_340KJ870450LPV   I13V, E35D, M36I, R41K, H69K, V77I, L89MA
 415415_634KJ870660APV   I13V, E35D, M36I, R41K, L63P, G68E, H69K, L89MA
 177177_276KJ870397LPV   I13V, I15V, E35D, M36I, R41K, H69K, V77I, L89M, I93LA
 3333_461KJ870540APV I54IL L10I, I13V, K14R, G16E, E35D, M36MI, R41K, H69K, V77I, L89I, I93LA
 262262_233KJ870366LPV   I13V, I15V, M36I, R41K, L63P, H69K, L89IM, I93LA
 193193_342KJ870451APV I47IVL33F, F53LI13V, I15V, K20T, E35D, M36I, R41K, H69K, V77I, L89MA
 9494_213KJ870349APV   I13V, E35D, M36I, R41K, H69K, I72IV, V77VI, L89MA
 474474_650KJ870672LPV   I13V, E35D, M36I, R41K, L63LIPT, H69K, T74S, L89M, I93LA
 314314_416KJ870508LPV   L10LI, T12S, I13V, K14KR, E35D, M36I, R41K, H69K, V77I, L89MA
Nerrienet (2014)T0630085T0630085JN675756LPV M46I, I50V, I54V, V82AL33F, T74PL10I, I13V, G16A, M36I, R41K, L63V, H69K, K70R, L89MA
 U0407179U0407179JN675767LPV M46I, I84V, L90ML10F, L33F, F53L, Q58E, G73GS, N88G, L89VI13V, K20T, E35D, M36I, R41K, K55R, R57K, L63P, I66IF, H69K, A71VA
 R1113090R1113090JN675748LPV M46I, I47V, L76V, I84VL10FI13V, G16Q, L19V, K20I, E35D, M36I, P39S, R41K, K55R, D60E, I66F, H69K, A71AV, L89MA
 T0528149T0528149JN675798LPV  L33FI13V, R41K, K43R, L63I, I64V, H69K, K70R, L89M, I93LA
 T0807129T0807129JN675757LPV M46I, I47V, L76V, V82FQ58EL10I, I13V, G16E, K20I, E35DN, M36I, N37ND, K55R, L63T, I64V, H69K, I72T, L89MA
 U0907156U0907156JN675771LPV V32I, M46I, I47V, I54M, L90ML33F, Q58E, N83DL10V, I13V, G16A, M36I, N37D, R41K, K55R, D60N, L63P, I64V, H69K, K70R, A71IV, G73GD, L89IA
Diaz (2015)RenG16380RenG16380KT747408PINAM46I, I54V, L76V, V82A L10I, I13V, I15V, G16A, L19IV, K20I, E21Q, E35D, M36I, N37E, R41K, I62V, L63P, I64V, H69K, A71T, T74TSA
 RenG17023RenG17023KT748051PINA  L10I, I13V, K14R, I15V, E35D, M36I, R41K, L63V, E65D, H69K, L89MA
 RenG14159RenG14159KT745187PINAI54L, V82AL33F, K43KPQT, N83DL10V, I13V, K14R, G16A, K20R, E35D, M36I, N37NDGS, R41K, L63V, H69K, K70R, L89IA
 RenG10743RenG10743KT741771PINAM46I, I54IV, V82VA, L90ML23LI, F53FLL10IV, T12K, I13V, K14W, G16E, L19P, K20V, E35G, M36I, N37D, R41K, I62V, L63H, I64V, H69K, A71I, T74S, V77I, L89M, I93MA
Jenabian (2015)DR12DR12KF735823PINA  L10I, I13V, I15V, E35D, M36I, N37D, R41K, K43KR, R57RK, E65D, H69K, L89MA
 DR09DR09KF735820PINA  I13V, E35N, M36I, N37D, R41K, L63P, H69K, V77I, L89MA
 DR06DR06KF735817PINA  L10V, I13V, K14R, G16E, L19V, K20KR, E35N, M36I, N37D, R41K, Q61G, L63T, E65D, H69K, L89MA
 DR05DR05KF735816PINA  I13V, K20R, E35N, M36I, N37D, R41K, K43R, R57K, L63P, H69K, K70R, L89MA
Laga (2015)ARM102ARM102KF692207LPV   L10V, I13V, I15V, E35D, M36I, R41K, H69K, V77I, L89MA
 AM048AM048KM023157NFV   I13V, K14R, E35D_IN, M36L, R41K, L63P, H69K, V77I, L89M, I93LA
 AM064AM064KM023160NFV   I13V, G16E, E35D, M36I, R41K, H69K, V77I, L89M, I93LA
 ARM094ARM094KF692203SQV, RTV   I13V, K14R, E35D, M36I, N37D, R41K, H69K, L89MA
Sutherland (2015)22_POSTKT351832LPV   I13V, K14KR, E35D, M36I, R41K, R57K, H69K, L89MA
 1111_POSTKT351805LPV   L10V, I13V, E35D, M36I, R41K, R57K, D60E, H69K, V75M, L89M, I93L, T96P, N98DA
 99_POSTKT351846LPV   I13V, K20I, E35D, M36I, R41K, H69KR, L89MA
 55_POSTKT351838LPV   I13V, E35D, M36I, R41K, R57K, D60E, H69KA
 66_POSTKT351840LPV I54V I13V, E35D, M36I, R41K, R57K, H69K, L89MA
 88_POSTKT351844LPV I54V I13V, E35D, M36I, R41K, R57K, H69K, L89MA
 44_POSTKT351836LPV M46MI, V82VA L10I, I13V, K14KR, K20I, E35N, M36I, R41K, R57K, H69K, V77I, L89MA
Abdellaziz (2016)1513715137KT339026PINA  L10I, I13V, G16E, L19P, K20V, E35D, M36I, P39S, R41K, H69K, L89MA
 1505115051KT339029PINAV32I, M46I, V82AL10F, K43T, L89VI13V, K20M, M36I, L63P, H69K, A71VA
Inzaule (2016)1.02781.0278HM164116NFV   T12S, I13V, L19V, E35D, M36I, R41K, R57K, Q58QR, L63A, H69K, L89MA
 1.04571.0457HM164122NFV   L10V, I13V, K14R, E35D, M36I, N37D, R41K, R57K, D60E, H69K, L89MA
 1.03571.0357HM164130NFV   I13V, T31P, E35D, M36I, N37D, R41K, K43N, R57N, D60E, H69K, L89MA
 1.0411.041HM164127NFV   T12TS, I13V, K14R, E35D, M36I, R41K, R57K, L63P, H69K, L89MA
 1.05171.0517HM164118NFV   L10I, I13V, E35D, M36I, N37D, R41K, R57K, H69K, L89MA
 1.04961.0496HM164123NFV   I13V, E35D, M36I, N37D, R41K, R57K, L63A, H69K, L89MA
Ndahimana Jd Riedel (2016)20752075KT982528LPV   L10LI, I13V, E35D, M36I, R41K, R57RK, H69K, L89MA
 20372037KT982526LPV   L10IV, I13V, G16GE, E35D, M36I, P39PS, R41K, K45KR, H69K, L89MA
 21612161KT982531LPV   L10I, I13V, K14R, I15V, G16E, E35D, M36I, P39PS, R41K, R57K, H69K, L89MA
 21342134KT982488LPV   I13V, M36I, R41K, H69K, L89MA
 21242124KT982530LPV   I13V, I15IV, E35D, M36I, R41K, R57K, L63LP, H69K, L89MA
 20662066KT982493LPV   L10I, I13V, K14R, K20R, E35D, M36I, N37D, R41K, K45R, R57K, L63V, E65D, H69K, L89MA
 21402140KT982495LPV M46I, I54V, L76V, V82A L10V, I13V, G16E, K20R, E35D, M36I, R41KT, R57K, L63R, H69K, L89I, T91SA
 20802080KT982497LPV   I13V, I15V, G16E, K20R, E35D, M36I, R41K, R57K, H69K, K70KR, L89MA
 21372137KT982502LPV   L10I, I13V, G16E, E35D, M36I, R57K, L63V, H69K, L89MA
 21332133KT982485LPV M46I, I54V, V82A, I84VL10FI13V, G16E, K20R, E35D, M36I, N37E, R41K, K45I, R57K, Q61N, L63H, H69K, K70R, I72IT, L89MA
 20292029KT982523LPV I54V, V82VAL33F, T74PL10I, I13V, E35D, M36I, R41K, R57K, L63T, H69K, V77I, L89MA
 21592159KT982532LPV   I13V, K14R, I15V, E35D, M36I, R41K, R57K, H69K, L89MA
 21652165KT982498LPV M46I, I54V, V82AL10F, L33FI13V, E35D, M36I, N37D, P39Q, R41K, K45I, R57K, D60NS, Q61E, L63P, H69Q, L89I, T91SA