<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype A
Gene PR
Mutation L10V
Rx >= 1 PI
IncludeMixtures No
References 26
Patients 50
Isolates 55
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Weidle (2001)PW_UG4399PW_UG4399a RTV69V82AL33FL10V, I13V, K20R, E35D, M36I, R41K, R57K, C67Y, H69K, L89MA
Yahi (2001)NY_M71M71AY010433IDV   L10V, I13V, K14R, G16E, E35D, M36I, R41K, R57K, H69K, L89MA
 NY_M73M73AY010435IDV   L10V, I13V, K14R, G16E, K20KI, E35D, M36I, R41K, R57K, H69K, T74TA, L89MA
Shafer (2003)A384_09830983bEF548169NFV43  L10V, I13V, K20T, E35D, M36I, R41K, R57K, H69K, L89M, I93MA
Montes (2004)MB_patSAN01_SANC718AJ577992SQV, IDV, RTV143M46I, I84V, L90MG73S, L89VL10V, I13V, G16A, K20R, E35D, M36I, N37E, R41K, D60E, I62V, L63P, H69KA
 MB_patMAK01_MAK719AJ577939SQV, RTV, NFV, LPV203M46I, I54V, I84VF53LL10V, I13V, K14R, G17E, K20I, E35D, M36I, R41K, H69K, T74A, L89MA
Chantratita (2005)14-006814-0068DQ130454PINA  W6R, L10V, I13V, G16E, E35D, M36I, R41K, K43R, L63S, H69K, L89MA
 G563G563DQ130136PINAD30N, M46IN88DW6R, L10V, K20R, E35D, M36I, R41K, L63P, H69K, V77I, I93LA
 G589G589DQ130152PINA  L10V, I13V, G16A, L19M, K20I, E35N, M36I, N37D, R41K, D60E, Q61E, L63P, H69K, L89M, I93LA
 NP304NP304DQ130384PINAG48V, I54T, V82A L10V, T12P, I13V, G16A, K20I, E35N, M36I, R41K, R57K, L63P, H69K, T74S, L89MA
 NP313NP313DQ130391PINA  L10V, I13V, K14N, G16E, K20R, E35D, M36I, R41K, K43R, L63T, H69K, K70R, L89MA
Non-B Workgroup (2005)TK1030TK1030a SQV, RTV, IDV305  L10V, I13V, G16GE, E35D, M36I, R41K, R57K, L63PS, H69K, L89MA
 TK2012TK2012 RTV, IDV, SQV186I54V, L90M L10V, I13V, K14R, I15V, K20R, E35D, M36I, R41K, R57K, I62V, H69K, T74S, L89IA
 TK3017TK3017 RTV174L90M L10V, I13V, G16E, K20R, E35D, M36I, R41K, L63T, H69K, L89MA
  TK3017a RTV222L90M L10V, I13V, G16E, K20R, E35D, M36I, P39PS, R41K, L63T, H69K, L89MA
  TK3017b RTV230L90M L10V, I13V, G16E, K20R, E35D, M36I, P39PS, R41K, L63T, H69K, L89MA
  TK3017c RTV249L90M L10V, I13V, G16E, K20R, E35D, M36I, P39PS, R41K, L63T, H69K, L89MA
 TK3029TK3029 SQV, NFV149L90M L10V, I13V, K20T, E35D, M36I, R41K, H69K, T74S, L89IA
 TK4003TK4003 NFV116 N83DL10V, I13V, K14R, G16E, E35D, M36I, R41K, K45R, R57K, L63T, H69K, K70R, L89M, I93LA
  TK4003a NFV215I54VL33I, N83DL10V, I13V, K14R, G16E, A22V, E35D, M36I, R41K, K45R, L63T, H69R, K70R, L89IA
Weber (2005)M74228M74228AY677423NFV75  L10V, I13V, K14R, G16E, K20R, E35D, M36I, N37D, R41K, H69K, I72T, L89I, Q92KA
 F51354F51354AY677444SQV, NFV115  L10V, I13V, K14R, G16E, K20T, E35D, M36I, R41K, R57K, L63T, H69K, I72T, T74TA, L89MA
 F73291F73291AY677477NFV195M46LL33I, N83DL10V, I13V, A22V, E35D, M36I, R41K, I62V, L63PS, H69K, T74S, L89I, I93LA
Baxter (2006)12-20242024-30709DQ876698PINAM46L, I54VL33F, N83DL10V, I13V, K14R, E35D, M36IL, N37ND, R41K, R57K, H69Q, L89MA
 48-12041204-30709DQ877748PINAM46I, G48Q, I54T, V82FL33F, Q58E, N83DL10V, I13V, G16E, E35D, M36L, P39S, R57K, I62V, L63V, H69K, T74A, L89MA
 48-12531253-30605DQ877778PINA  L10V, T12TP, I13V, K14R, G16E, K20R, E35D, M36I, R41K, R57RK, Q61QE, I62IV, L63CS, H69K, L89MA
 48-26142614-30624DQ877904PINAM46L, I54V, V82AL33F, F53LL10V, T12I, I15V, G16E, L19V, K20R, E35D, M36I, R41K, R57K, L63T, E65D, I72T, I85V, L89MA
 48-30453045-30317DQ877957PINAG48V, I54S, V82AL33F, Q58E, N83DL10V, I13V, K14R, I15V, M36L, R41RK, D60DE, I62IV, L63P, H69K, I85V, L89I, T91TSA
 48-33333333-30929DQ878227PINAM46I, I47V, I54V, I84VL33F, G73SL10V, I13V, I15V, K20T, E35D, M36I, P39S, R41K, Q61D, I62V, L63P, I66F, H69K, T74S, L89TA
 48-42024202-30804DQ878434PINA  L10V, I13V, K14KR, I15V, G16E, E35D, M36I, R41K, K45R, L63T, H69KA
Laurent (2006)CK2-7502CM-75AM279446IDV39  L10V, I13V, I15V, E35D, M36I, R41K, R57K, D60E, H69K, L89MA
Seyler (2007)483CS_483 NFV162  L10V, I13V, G16GE, E35D, M36I, R41K, H69K, K70R, L89MA
Gody (2008)Pt047Pt047 IDV   L10V, I13V, G16E, E35D, M36I, N37D, L63AS, H69K, I72V, L89MA
Rosen-Zvi (2008)4600p46-1 RTV, SQV, NFV, APV141M46MIL, I54V, V82M, I84V, L90ML33F, Q58EL10V, T12V, I13IV, K14KR, I15V, K20R, E35D, M36I, N37E, R41K, R57K, L63P, H69K, L89IA
Dau (2010)10412A10412AGU582000PINA  L10V, I13V, E35D, M36I, R41K, L63V, I64V, H69KA
Knops (2010)ID1585ID1585-GT1GU271168SQV, NFV, RTV, APV I54V, V82M, I84V, L90ML33F, Q58EL10V, T12V, I13IV, K14KR, I15V, K20R, E35D, M36I, N37E, R41K, R57K, L63P, H69K, L89IA
  ID1585-GT2GU271169SQV, NFV, RTV, APV, LPV64I54V, L76V, V82M, L90ML33F, Q58E, G73S, L89VL10V, T12V, I13V, I15V, K20R, E35D, M36I, N37E, R57K, I62IV, L63P, H69KA
Charpentier (2011)4CP001-045 Unknown, IDVNAL90ML33IL10V, I13V, L19F, K20T, E35D, M36I, R41K, R57K, L63P, H69K, T74S, L89IA
El Annaz (2012)929929.PRJN185233PINA  L10V, I13V, K14R, G16E, E35D, M36I, R41K, H69K, L89M, I93ILA
 18771877.PRJN185240PINA  L10V, I13V, I15V, M36I, L63P, H69K, L89MA
 52185218.PRJN185254IDV52  L10V, I13V, K14R, G16E, E35D, M36I, R41K, H69K, L89MA
Acharya (2014)DGP185DGP185KJ185355RTV, ATV M46I, I54V, V82A, N88SL24I, L33F, Q58EL5I, L10V, I13V, I15V, E35D, M36I, N37E, R41K, R57K, D60E, H69K, A71V, L89MA
 DGP122DGP122KJ185292LPV   L10V, I13V, I15V, K20R, E35D, M36I, N37D, R41K, K45R, R57K, H69K, K70R, L89MA
 DGP112DGP112KJ185282RTV, ATV   L10V, I13V, I15V, K20R, E35D, M36I, N37D, R41K, K45R, R57K, H69K, K70R, L89MA
Grossman (2014)20882088KC184354LPV52  L10V, G16E, K20R, E35D, M36I, R41K, H69K, L89M, I93LA
 13851385KC184183LPV52  L10V, E35D, M36I, R41K, H69K, L89MA
 20352035KC184345LPV52  L10V, E35D, M36I, R41N, L63P, H69K, K70R, L89M, I93ILA
Kolomeets (2014)309309_408KJ870502LPV   L10V, E35D, M36I, R41K, H69K, L89M, I93LA
Nerrienet (2014)U0907156U0907156JN675771LPV V32I, M46I, I47V, I54M, L90ML33F, Q58E, N83DL10V, I13V, G16A, M36I, N37D, R41K, K55R, D60N, L63P, I64V, H69K, K70R, A71IV, G73GD, L89IA
Diaz (2015)RenG14159RenG14159KT745187PINAI54L, V82AL33F, K43KPQT, N83DL10V, I13V, K14R, G16A, K20R, E35D, M36I, N37NDGS, R41K, L63V, H69K, K70R, L89IA
Jenabian (2015)DR06DR06KF735817PINA  L10V, I13V, K14R, G16E, L19V, K20KR, E35N, M36I, N37D, R41K, Q61G, L63T, E65D, H69K, L89MA
Laga (2015)ARM102ARM102KF692207LPV   L10V, I13V, I15V, E35D, M36I, R41K, H69K, V77I, L89MA
Sutherland (2015)1111_POSTKT351805LPV   L10V, I13V, E35D, M36I, R41K, R57K, D60E, H69K, V75M, L89M, I93L, T96P, N98DA
Inzaule (2016)1.04571.0457HM164122NFV   L10V, I13V, K14R, E35D, M36I, N37D, R41K, R57K, D60E, H69K, L89MA
Ndahimana Jd Riedel (2016)21402140KT982495LPV M46I, I54V, L76V, V82A L10V, I13V, G16E, K20R, E35D, M36I, R41KT, R57K, L63R, H69K, L89I, T91SA