Protease Inhibitors

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Protease Inhibitors

Subtype	A
Gene	PR
Mutation	L10V
Rx	>= 1 PI
IncludeMixtures	No

References	19
Patients	48
Isolates	52

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	PIs	Wks	PIMajorDRMs	PIMinorDRMs	OtherMut	Subtype
Weidle (2001)	PW_UG4399	PW_UG4399a		RTV	69	V82A	L33F	L10V, I13V, K20R, E35D, M36I, R41K, R57K, C67Y, H69K, L89M	A
Yahi (2001)	NY_M71	M71	AY010433	IDV				L10V, I13V, K14R, G16E, E35D, M36I, R41K, R57K, H69K, L89M	A
	NY_M73	M73	AY010435	IDV				L10V, I13V, K14R, G16E, K20KI, E35D, M36I, R41K, R57K, H69K, T74TA, L89M	A
Shafer (2003)	A384_0983	0983b	EF548169	NFV	43			L10V, I13V, K20T, E35D, M36I, R41K, R57K, H69K, L89M, I93M	A
Montes (2004)	MB_patSAN	01_SANC718	AJ577992	SQV, IDV, RTV	143	M46I, I84V, L90M	G73S, L89V	L10V, I13V, G16A, K20R, E35D, M36I, N37E, R41K, D60E, I62V, L63P, H69K	A
Non-B Workgroup (2005)	TK1030	TK1030a		SQV, RTV, IDV	305			L10V, I13V, G16GE, E35D, M36I, R41K, R57K, L63PS, H69K, L89M	A
	TK2012	TK2012		RTV, IDV, SQV	186	I54V, L90M		L10V, I13V, K14R, I15V, K20R, E35D, M36I, R41K, R57K, I62V, H69K, T74S, L89I	A
	TK3017	TK3017		RTV	174	L90M		L10V, I13V, G16E, K20R, E35D, M36I, R41K, L63T, H69K, L89M	A
		TK3017a		RTV	222	L90M		L10V, I13V, G16E, K20R, E35D, M36I, P39PS, R41K, L63T, H69K, L89M	A
		TK3017b		RTV	230	L90M		L10V, I13V, G16E, K20R, E35D, M36I, P39PS, R41K, L63T, H69K, L89M	A
		TK3017c		RTV	249	L90M		L10V, I13V, G16E, K20R, E35D, M36I, P39PS, R41K, L63T, H69K, L89M	A
	TK3029	TK3029		SQV, NFV	149	L90M		L10V, I13V, K20T, E35D, M36I, R41K, H69K, T74S, L89I	A
	TK4003	TK4003		NFV	116		N83D	L10V, I13V, K14R, G16E, E35D, M36I, R41K, K45R, R57K, L63T, H69K, K70R, L89M, I93L	A
		TK4003a		NFV	215	I54V	L33I, N83D	L10V, I13V, K14R, G16E, A22V, E35D, M36I, R41K, K45R, L63T, H69R, K70R, L89I	A
	TK5011	TK5011		IDV	34			L10V, I13IV, K14KR, E35D, M36I, R41K, R57K, H69K, L89M	A
Weber (2005)	F51354	F51354	AY677444	SQV, NFV	115			L10V, I13V, K14R, G16E, K20T, E35D, M36I, R41K, R57K, L63T, H69K, I72T, T74TA, L89M	A
	F73291	F73291	AY677477	NFV	195	M46L	L33I, N83D	L10V, I13V, A22V, E35D, M36I, R41K, I62V, L63PS, H69K, T74S, L89I, I93L	A
Baxter (2006)	12-2024	2024-30709	DQ876698	PI	NA	M46L, I54V	L33F, N83D	L10V, I13V, K14R, E35D, M36IL, N37ND, R41K, R57K, H69Q, L89M	A
	48-1204	1204-30709	DQ877748	PI	NA	M46I, G48Q, I54T, V82F	L33F, Q58E, N83D	L10V, I13V, G16E, E35D, M36L, P39S, R57K, I62V, L63V, H69K, T74A, L89M	A
	48-1253	1253-30605	DQ877778	PI	NA			L10V, T12TP, I13V, K14R, G16E, K20R, E35D, M36I, R41K, R57RK, Q61QE, I62IV, L63CS, H69K, L89M	A
	48-3045	3045-30317	DQ877957	PI	NA	G48V, I54S, V82A	L33F, Q58E, N83D	L10V, I13V, K14R, I15V, M36L, R41RK, D60DE, I62IV, L63P, H69K, I85V, L89I, T91TS	A
	48-4202	4202-30804	DQ878434	PI	NA			L10V, I13V, K14KR, I15V, G16E, E35D, M36I, R41K, K45R, L63T, H69K	A
Laurent (2006)	CK2-75	02CM-75	AM279446	IDV	39			L10V, I13V, I15V, E35D, M36I, R41K, R57K, D60E, H69K, L89M	A
Seyler (2007)	265	CS_265		IDV	66			L10V, I13V, L19P, K20I, M36I, R41K, K43R, L63LP, H69K, L89M	A
	483	CS_483		NFV	162			L10V, I13V, G16GE, E35D, M36I, R41K, H69K, K70R, L89M	A
von Wyl (2007)	85	495945	EF449807	PI	NA			L10V, I13V, E35D, M36I, R41K, H69K, L89M	A
	134	5191462	EF449882	PI	NA			L10V, I13V, E35D, M36I, R41K, K45R, R57K, L63V, L89M	A
Gody (2008)	Pt047	Pt047		IDV				L10V, I13V, G16E, E35D, M36I, N37D, L63AS, H69K, I72V, L89M	A
Dau (2010)	10412A	10412A	GU582000	PI	NA			L10V, I13V, E35D, M36I, R41K, L63V, I64V, H69K	A
El Annaz (2012)	929	929.PR	JN185233	PI	NA			L10V, I13V, K14R, G16E, E35D, M36I, R41K, H69K, L89M, I93IL	A
	1429	1429.PR	JN185237	PI	NA			L10V, I13V, K14R, I15V, M36I, L63P, H69K, L89M	A
	1877	1877.PR	JN185240	PI	NA			L10V, I13V, I15V, M36I, L63P, H69K, L89M	A
	5218	5218.PR	JN185254	IDV	52			L10V, I13V, K14R, G16E, E35D, M36I, R41K, H69K, L89M	A
Kouri (2012)	CU376-10	CU376-10	JQ585390	PI	NA	G48V, I54V, V82A		L10V, T12I, I13V, K20I, E35D, M36I, N37DE, R41K, H69K, T74S, L89I	A
Grossman (2014)	2088	2088	KC184354	LPV	52			L10V, G16E, K20R, E35D, M36I, R41K, H69K, L89M, I93L	A
	1385	1385	KC184183	LPV	52			L10V, E35D, M36I, R41K, H69K, L89M	A
	2035	2035	KC184345	LPV	52			L10V, E35D, M36I, R41N, L63P, H69K, K70R, L89M, I93IL	A
Kolomeets (2014)	309	309_408	KJ870502	LPV				L10V, E35D, M36I, R41K, H69K, L89M, I93L	A
Diaz (2015)	RenG16883	RenG16883	KT747911	PI	NA	M46I	V32A, L33F, F53L, T74TP	L10V, I13V, I15V, K20R, E35D, M36I, R41K, R57K, Y59YH, Q61DN, I66F, L89I	A
	RenG17291	RenG17291	KT748319	PI	NA	M46I, I50L, V82A, N88S	L33F, K43T	L10V, I13V, K20R, E35D, M36I, R41KN, D60E, Q61D, L63P, V77VI, L89M	A
	RenG16869	RenG16869	KT747897	PI	NA	M46L, I54V, V82A, L90M	L33I	L10V, T12K, I13V, K20R, E35D, M36I, R41K, F53I, K55N, R57K, D60E, Q61N, I62V, L63S, A71T, L89I, Q92K	A
	RenG16261	RenG16261	KT747289	PI	NA			L10V, I13V, G17D, K20R, E35D, M36I, R41K, Q61N, I62V, L89M	A
	RenG14159	RenG14159	KT745187	PI	NA	I54L, V82A	L33F, K43KPQT, N83D	L10V, I13V, K14R, G16A, K20R, E35D, M36I, N37NDGS, R41K, L63V, H69K, K70R, L89I	A
	RenG15222	RenG15222	KT746250	PI	NA			L10V, I13V, K20R, M36I, R41K, K43KR, L63V, H69K, L89M	A
	RenG15076	RenG15076	KT746104	PI	NA	M46I, V82F	F53L, N83D	W6V, L10V, I13A, A22V, E35D, M36I, R41K, K43R, R57K, Q61N, I62V, L63P, H69R, T74S, L89I, I93L	A
	RenG13646	RenG13646	KT744674	PI	NA			L10V, I13V, E35D, M36I, P39Q, R41K, R57K, Q61N, H69Y, V77I, L89M	A
	RenG14896	RenG14896	KT745924	PI	NA	M46I, I47V, I54V, V82F	L33F, K43IT	L10V, I13V, K20R, E35D, M36I, R41X, D60DE, Q61D, E65D, I72T, I85V, L89M	A
	RenG12430	RenG12430	KT743458	PI	NA	D30N, M46L, I50L, V82A	N88D	L10V, T12A, I13V, I15S, G16R, K20R, E21Q, E35D, M36I, N37T, R41K, K45R, R57K, Q61N, I62V, L63AD, A71V, I72IV, T74TS, I85IV, Q92QR	A
	RenG12636	RenG12636	KT743664	PI	NA	D30N, V32VI, M46I, I47V, I54LV	F53FL, L76LM, N88D	L10V, T12IM, I13A, K20T, A22AV, E35N, M36I, N37ND, R41K, K45R, R57K, Q61N, L63C, A71V, T74S, L89T, Q92R	A
	RenG10406	RenG10406	KT741434	PI	NA	V32I, M46I, I54V, V82A, I84V, L90M	L33F, G73C	L10V, T12N, I13V, G16A, L19P, K20R, E34Q, E35D, M36I, R41K, F53I, K55R, R57K, Q61N, L63P, A71T, Q92K	A
Laga (2015)	ARM102	ARM102	KF692207	LPV				L10V, I13V, I15V, E35D, M36I, R41K, H69K, V77I, L89M	A
Inzaule (2016)	1.0457	1.0457	HM164122	NFV				L10V, I13V, K14R, E35D, M36I, N37D, R41K, R57K, D60E, H69K, L89M	A

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