<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype A
Gene PR
Mutation L10V
Rx >= 1 PI
IncludeMixtures No
References 15
Patients 33
Isolates 37
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Weidle (2001)PW_UG4399PW_UG4399a RTV69V82AL33FL10V, I13V, K20R, E35D, M36I, R41K, R57K, C67Y, H69K, L89MA
Yahi (2001)NY_M71M71AY010433IDV   L10V, I13V, K14R, G16E, E35D, M36I, R41K, R57K, H69K, L89MA
 NY_M73M73AY010435IDV   L10V, I13V, K14R, G16E, K20KI, E35D, M36I, R41K, R57K, H69K, T74TA, L89MA
Shafer (2003)A384_09830983bEF548169NFV43  L10V, I13V, K20T, E35D, M36I, R41K, R57K, H69K, L89M, I93MA
Montes (2004)MB_patSAN01_SANC718AJ577992SQV, IDV, RTV143M46I, I84V, L90MG73S, L89VL10V, I13V, G16A, K20R, E35D, M36I, N37E, R41K, D60E, I62V, L63P, H69KA
Non-B Workgroup (2005)TK1030TK1030a SQV, RTV, IDV305  L10V, I13V, G16GE, E35D, M36I, R41K, R57K, L63PS, H69K, L89MA
 TK2012TK2012 RTV, IDV, SQV186I54V, L90M L10V, I13V, K14R, I15V, K20R, E35D, M36I, R41K, R57K, I62V, H69K, T74S, L89IA
 TK3017TK3017 RTV174L90M L10V, I13V, G16E, K20R, E35D, M36I, R41K, L63T, H69K, L89MA
  TK3017a RTV222L90M L10V, I13V, G16E, K20R, E35D, M36I, P39PS, R41K, L63T, H69K, L89MA
  TK3017b RTV230L90M L10V, I13V, G16E, K20R, E35D, M36I, P39PS, R41K, L63T, H69K, L89MA
  TK3017c RTV249L90M L10V, I13V, G16E, K20R, E35D, M36I, P39PS, R41K, L63T, H69K, L89MA
 TK3029TK3029 SQV, NFV149L90M L10V, I13V, K20T, E35D, M36I, R41K, H69K, T74S, L89IA
 TK4003TK4003 NFV116 N83DL10V, I13V, K14R, G16E, E35D, M36I, R41K, K45R, R57K, L63T, H69K, K70R, L89M, I93LA
  TK4003a NFV215I54VL33I, N83DL10V, I13V, K14R, G16E, A22V, E35D, M36I, R41K, K45R, L63T, H69R, K70R, L89IA
 TK5011TK5011 IDV34  L10V, I13IV, K14KR, E35D, M36I, R41K, R57K, H69K, L89MA
Weber (2005)F51354F51354AY677444SQV, NFV115  L10V, I13V, K14R, G16E, K20T, E35D, M36I, R41K, R57K, L63T, H69K, I72T, T74TA, L89MA
 F73291F73291AY677477NFV195M46LL33I, N83DL10V, I13V, A22V, E35D, M36I, R41K, I62V, L63PS, H69K, T74S, L89I, I93LA
Baxter (2006)12-20242024-30709DQ876698PINAM46L, I54VL33F, N83DL10V, I13V, K14R, E35D, M36IL, N37ND, R41K, R57K, H69Q, L89MA
 48-12041204-30709DQ877748PINAM46I, G48Q, I54T, V82FL33F, Q58E, N83DL10V, I13V, G16E, E35D, M36L, P39S, R57K, I62V, L63V, H69K, T74A, L89MA
 48-12531253-30605DQ877778PINA  L10V, T12TP, I13V, K14R, G16E, K20R, E35D, M36I, R41K, R57RK, Q61QE, I62IV, L63CS, H69K, L89MA
 48-30453045-30317DQ877957PINAG48V, I54S, V82AL33F, Q58E, N83DL10V, I13V, K14R, I15V, M36L, R41RK, D60DE, I62IV, L63P, H69K, I85V, L89I, T91TSA
 48-42024202-30804DQ878434PINA  L10V, I13V, K14KR, I15V, G16E, E35D, M36I, R41K, K45R, L63T, H69KA
Laurent (2006)CK2-7502CM-75AM279446IDV39  L10V, I13V, I15V, E35D, M36I, R41K, R57K, D60E, H69K, L89MA
Seyler (2007)265CS_265 IDV66  L10V, I13V, L19P, K20I, M36I, R41K, K43R, L63LP, H69K, L89MA
 483CS_483 NFV162  L10V, I13V, G16GE, E35D, M36I, R41K, H69K, K70R, L89MA
von Wyl (2007)85495945EF449807PINA  L10V, I13V, E35D, M36I, R41K, H69K, L89MA
 1345191462EF449882PINA  L10V, I13V, E35D, M36I, R41K, K45R, R57K, L63V, L89MA
Gody (2008)Pt047Pt047 IDV   L10V, I13V, G16E, E35D, M36I, N37D, L63AS, H69K, I72V, L89MA
Dau (2010)10412A10412AGU582000PINA  L10V, I13V, E35D, M36I, R41K, L63V, I64V, H69KA
El Annaz (2012)929929.PRJN185233PINA  L10V, I13V, K14R, G16E, E35D, M36I, R41K, H69K, L89M, I93ILA
 14291429.PRJN185237PINA  L10V, I13V, K14R, I15V, M36I, L63P, H69K, L89MA
 18771877.PRJN185240PINA  L10V, I13V, I15V, M36I, L63P, H69K, L89MA
 52185218.PRJN185254IDV52  L10V, I13V, K14R, G16E, E35D, M36I, R41K, H69K, L89MA
Kouri (2012)CU376-10CU376-10JQ585390PINAG48V, I54V, V82A L10V, T12I, I13V, K20I, E35D, M36I, N37DE, R41K, H69K, T74S, L89IA
Grossman (2014)20882088KC184354LPV52  L10V, G16E, K20R, E35D, M36I, R41K, H69K, L89M, I93LA
 13851385KC184183LPV52  L10V, E35D, M36I, R41K, H69K, L89MA
 20352035KC184345LPV52  L10V, E35D, M36I, R41N, L63P, H69K, K70R, L89M, I93ILA