<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype A
Gene PR
Mutation L10I
Rx >= 1 PI
IncludeMixtures No
References 27
Patients 69
Isolates 76
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Yahi (2001)NY_M29M29AY010392IDV M46I, I54V, V82F L10I, I13V, I15V, K20KI, E35D, M36I, R41K, D60E, I62IV, H69Q, L89IA
Holguin (2003)SP_LP17SP_LP17AF455614PINA  L10I, I13V, K14R, E35D, M36I, R41K, H69K, L89MA
 SP_LP5SP_LP5AF455604PINA  L10I, I13V, K14R, E35D, M36I, R41K, L63V, H69K, L89MA
Montes (2004)MB_patSAA00_SAA713AJ577989NFV, SQV21  L10I, I13V, I15V, E35D, M36I, R41K, H69K, L89MA
  01_SAA704AJ577990NFV, SQV21  L10I, I13V, I15V, E35D, M36I, R41K, H69K, L89MA
 MB_patMAK01_MAK707AJ577938SQV, RTV, NFV182I54V, I84V, L90MV32G, F53LL10I, I13V, K14R, G17E, K20I, E35D, M36I, R41K, L63P, H69K, T74A, L89MA
  02_MAK737AJ577940SQV, RTV, NFV, LPV225M46I, I47V, I54V, I84VF53LL10I, I13V, K14R, G17E, K20I, E35D, M36I, N37E, R41K, H69K, T74A, L89MA
Chantratita (2005)G586G586DQ130150PINAV82AQ58EW6R, L10I, I13V, G16E, K20I, E35D, M36I, R41K, L63T, H69K, L89MA
 G738G738DQ130229PINA  L10I, I13V, G16E, K20R, E35D, M36I, R41K, L63T, G68E, H69K, K70R, I72V, L89M, T91VA
 NP266NP266DQ130348PINA  L10I, I13V, G16E, K20R, E35D, M36I, R41K, C67G, H69K, K70R, L89MA
Hsu (2005)BAA161436BAA161436AY870234SQV, RTV26 L33FL10I, I13V, R41K, I62V, L63I, H69K, K70R, V82I, L89M, F99LA
Non-B Workgroup (2005)UK1516UK1516 PI, LPVNAI54L L10I, I13V, G16E, K20T, E35D, M36I, R41K, R57K, L63T, H69K, T74S, V82VI, I85V, L89MA
 IL276IL276 IDV81  L10I, E35D, M36I, R41K, R57K, L63T, H69R, L89M, I93LA
 UK2149UK2149AY900859Unknown, LPVNAM46I, L76V, I84VL33I, N83DL10I, I13V, A22V, E35D, M36I, N37D, R41K, K45R, R57K, L63P, A71V, L89IA
 TK1001TK1001 IDV129  L10I, I13V, K14R, E35D, M36I, R41K, R57K, H69K, L89MA
  TK1001a IDV179V82A L10I, I13V, K14R, E35D, M36I, R41K, R57K, H69K, L89IA
 TK1030TK1030 SQV, RTV, IDV146  L10I, I13V, G16E, E35D, M36I, R41K, R57K, L63S, H69K, L89MA
 TK2029TK2029 IDV39  L10I, I13V, K14R, G16GE, E35D, M36I, R41K, K45R, R57K, L63P, H69K, V77I, L89MA
 TK5005TK5005 SQV, IDV, RTV, NFV, LPV180G48V, I54T, V82A, L90M L10I, I13V, K14R, G17D, K20R, E34N, E35D, M36I, R41K, R57K, D60E, I62V, L63P, H69K, A71V, L89IA
  TK5005a SQV, IDV, RTV, NFV, LPV196G48V, I54T, L90M L10I, I13V, K14R, G17D, K20R, E34N, E35D, M36I, R41K, R57K, D60E, I62V, L63P, H69K, A71IV, L89I, I93IMA
 TK5012TK5012 IDV54  L10I, I13V, K14R, G16E, K20R, E35D, M36I, R41K, L63T, H69K, L89MA
  TK5012a IDV, LPV152  L10I, I13V, K14KR, G16E, K20R, E35D, M36I, R41K, L63T, H69K, L89MA
  TK5012c IDV, LPV215  L10I, I13V, K14KR, G16E, K20R, D25DG, E35D, M36I, R41K, L63ST, H69K, L89MA
 PL3403155128 IDV, NFV207M46I, I84VL89VL10I, T12S, I13V, L19V, K20I, E35D, N37D, L63P, I66F, H69K, K70R, A71VA
Weber (2005)F45753F45753AY677422SQV, NFV258  L10I, I13V, G16E, K20R, E35D, M36I, P39S, R41K, H69K, L89MA
 M50457M50457AY677433NFV94  L10I, T12S, I13V, K14KR, I15IV, K20I, E35D, M36I, N37S, R41K, K45R, H69K, A71V, L89TA
 F87084F87084AY677406IDV28  L10I, I13V, K14R, G16E, E35D, M36I, R41K, R57K, L63V, H69K, L89MA
 F78596F78596AY677480IDV18  L10I, I13V, I15L, K20I, E35D, M36I, L63S, H69K, L89MA
 M47502M47502AY677409NFV51N88NS L10I, I13V, K20KT, E35ED, M36I, R41K, L63T, I64IV, H69K, L89MA
 89M262689M2626AY677414SQV, NFV, RTV261I54V, L90MF53L, L89VL10I, I13V, K14R, K20I, E35D, M36I, N37E, R41K, R57K, H69K, A71V, T74SA
Baxter (2006)48-14321432-30818DQ877822PINAM46I, I54V, L76V, V82TL24IL10I, I13A, K20I, E35D, M36I, R41K, Q61H, L63P, H69K, T74S, L89IA
 48-32933293-30722DQ878198PINAM46I, I54V, L76V, V82A, L90MV11IL10I, T12E, I13V, I15V, K20I, E35N, M36I, N37D, R41K, I62V, L63P, H69K, K70KR, A71V, T74S, L89I, T91SA
 48-33163316-30818DQ878217PINAI54A, V82F L10I, T12TK, I13V, G16A, L19LV, K20I, E35N, M36I, R41K, D60E, L63P, H69K, T74S, V77I, L89MA
 48-41864186-30408DQ878420PINAI54V, V82AL24I, L33I, Q58E, N83DL10I, I13V, G16E, K20R, A22V, E35D, M36I, N37D, R41K, L63T, H69K, I72V, T74A, L89M, T91V, I93LA
 48-50215021-30606DQ878555PINAI54V, V82F, I84IV, L90ML33F, F53LL10I, V11L, I13V, I15V, G16E, L19P, K20I, E35N, M36I, K45V, L63T, H69K, L89MA
 48-50745074-30807DQ878584PINAG48V, I54S, V82A, L90MK43TL10I, I13V, K20I, E34K, E35D, M36I, N37D, R41K, I62V, L63P, H69K, A71V, T74S, L89IA
 48-50775077-30903DQ878587PINAM46L, I54V, V82AL24I, L33F, F53L, T74PL10I, I13V, L19I, K20R, E35D, M36I, N37D, Q61R, L63P, H69K, L89MA
 48-80538053-30818DQ879078PINAM46L, G48V, I54S, V82AL33I, F53LL10I, I13A, K14N, A22V, E35D, M36I, K55R, R57K, I62V, L63P, H69K, K70KR, T74S, L89IA
Laurent (2006)CK22-3503CM2-35AM279456IDV74I54IV, V82AL33LIL10I, I13V, E35D, M36I, R41K, K45R, L63P, H69K, L89TA
Sylla (2008)A2868A2868_C1EF525663IDV   L10I, I13V, G16E, K20R, E35D, M36I, R41K, H69K, K70R, I72R, L89MA
Koyalta (2009)33TCHAD-33FJ688184IDV26  L10I, I13V, G16A, K20I, E35D, M36I, R41K, H69Q, L89MA
Thomson (2009)SP_B_057RU_SP_B_057FJ009812RTV, IDV, LPV29  L10I, E35D, M36I, R41K, H69K, L89MA
Barber (2012)5085750857JQ361664LPV M46I, L76V, I84V L10I, I13V, G16E, M36I, R41K, L63T, H69K, L89MA
El Annaz (2012)13281328.PRJN185236PINA  L10I, I13V, E21Q, E35D, M36I, R41K, H69K, L89MA
Kouri (2012)CU108-10CU108-10JQ585364PINAV32I, I54L, I84VL33F, K43T, F53LL10I, I13V, I15S, L19LI, K20R, E35D, M36I, R41K, D60E, Q61E, I62V, L63T, I64IV, H69K, A71AV, T74A, P79A, L89MA
Rawizza (2013)LM3929LM3929KF241482LPV M46I, I47V, I54V, V82AF53L, Q58EL10I, I13V, K14R, I15V, K20I, L33L_L, E35G, M36I, R41K, K55R, L63T, I64M, L89MA
Van Zyl (2013)O4631671KC423313LPV26  L10I, I13V, G16E, K20R, E35D, M36I, R41K, R57K, E65D, H69K, I72V, L89MA
Acharya (2014)DGP156DGP156KJ185326RTV, ATV   L10I, I13V, I15V, K20R, E35D, M36I, N37D, R41K, K45R, R57K, H69K, K70R, L89MA
 DGP152DGP152KJ185322RTV, ATV   L5I, L10I, I13V, I15V, E35D, M36I, N37E, R41K, R57K, D60E, H69K, L89MA
 DGP088DGP088KJ185258RTV, ATV G48M, I54T, V82AL33IL10I, I13A, A22V, E35D, M36I, N37D, R41K, R57K, H69K, T74A, L89IA
Grossman (2014)16871687KC184219LPV52  Q7QK, L10I, K14R, G17GR, E35D, M36I, N37D, R41K, C67Y, H69K, L89MA
 18631863 LPV52  L10I, I13V, K14R, E35D, M36I, N37D, R41K, D60E, Q61E, L63V, H69K, L89M, I93LA
Kolomeets (2014)182182_327KJ870438LPV   L10I, I13V, K14R, G16E, E35D, M36I, R41K, L63T, E65D, H69K, L89MA
 195195_344KJ870452LPV   L10I, K14R, G16E, E35D, M36I, R41K, Q61QE, L63LI, H69KQ, L89M, I93LA
 297297_395KJ870495LPV   L10I, I13IV, K14R, G16E, E35D, M36I, R41K, L63LV, H69K, L89M, I93LA
 442442_639KJ870664LPV   L10I, I13V, K14R, G16E, E35D, M36I, N37D, R41K, H69K, V77I, L89MA
 313313_414KJ870506LPV   L10I, I13V, K14R, G16E, E35D, M36I, R41K, H69K, V77I, L89MA
 273273_442KJ870527LPV   L10I, I13V, K14KR, G16E, E35EDKN, M36I, R41K, I62V, H69K, T74S, V77I, L89MA
 7575_367KJ870472LPV   L10I, I13V, E35D, M36I, R41K, R57RK, Q61E, L63LIPT, I64IL, E65ED, H69K, V77VI, L89MA
 327327_464KJ870543LPV   R8P, L10I, K14R, G16E, M36I, R41K, W42G, H69KQ, L89MA
 3737_529KJ870586LPV   L10I, I13V, I15IV, E35D, M36I, N37D, R41K, H69K, V77I, L89MA
 110110_355KJ870462APV   L10I, I13V, K14R, G16E, E35D, M36I, R41K, H69K, L89MA
 3333_461KJ870540APV I54IL L10I, I13V, K14R, G16E, E35D, M36MI, R41K, H69K, V77I, L89I, I93LA
Nerrienet (2014)T0630085T0630085JN675756LPV M46I, I50V, I54V, V82AL33F, T74PL10I, I13V, G16A, M36I, R41K, L63V, H69K, K70R, L89MA
 T0807129T0807129JN675757LPV M46I, I47V, L76V, V82FQ58EL10I, I13V, G16E, K20I, E35DN, M36I, N37ND, K55R, L63T, I64V, H69K, I72T, L89MA
Diaz (2015)RenG16380RenG16380KT747408PINAM46I, I54V, L76V, V82A L10I, I13V, I15V, G16A, L19IV, K20I, E21Q, E35D, M36I, N37E, R41K, I62V, L63P, I64V, H69K, A71T, T74TSA
 RenG17023RenG17023KT748051PINA  L10I, I13V, K14R, I15V, E35D, M36I, R41K, L63V, E65D, H69K, L89MA
Jenabian (2015)DR12DR12KF735823PINA  L10I, I13V, I15V, E35D, M36I, N37D, R41K, K43KR, R57RK, E65D, H69K, L89MA
Sutherland (2015)44_POSTKT351836LPV M46MI, V82VA L10I, I13V, K14KR, K20I, E35N, M36I, R41K, R57K, H69K, V77I, L89MA
Abdellaziz (2016)1513715137KT339026PINA  L10I, I13V, G16E, L19P, K20V, E35D, M36I, P39S, R41K, H69K, L89MA
Inzaule (2016)1.05171.0517HM164118NFV   L10I, I13V, E35D, M36I, N37D, R41K, R57K, H69K, L89MA
Ndahimana Jd Riedel (2016)21412141KT982484LPV M46I, I54V, L76V, I84V L10I, I13A, K14R, I15V, K20I, E35N, M36I, R41K, K45R, K55R, R57K, I66F, H69K, L89I, I93VA
 21612161KT982531LPV   L10I, I13V, K14R, I15V, G16E, E35D, M36I, P39PS, R41K, R57K, H69K, L89MA
 20662066KT982493LPV   L10I, I13V, K14R, K20R, E35D, M36I, N37D, R41K, K45R, R57K, L63V, E65D, H69K, L89MA
 21372137KT982502LPV   L10I, I13V, G16E, E35D, M36I, R57K, L63V, H69K, L89MA
 20292029KT982523LPV I54V, V82VAL33F, T74PL10I, I13V, E35D, M36I, R41K, R57K, L63T, H69K, V77I, L89MA