Protease Inhibitors

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Protease Inhibitors

Subtype	A
Gene	PR
Mutation	L10I
Rx	>= 1 PI
IncludeMixtures	No

References	14
Patients	36
Isolates	41

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	PIs	Wks	PIMajorDRMs	PIMinorDRMs	OtherMut	Subtype
Yahi (2001)	NY_M29	M29	AY010392	IDV		M46I, I54V, V82F		L10I, I13V, I15V, K20KI, E35D, M36I, R41K, D60E, I62IV, H69Q, L89I	A
	NY_M35	M35	AY010399	NFV		M46I, L90M		L10I, I13V, K14R, G16E, K20I, E35DN, M36I, I62IV, L63S, C67D, H69R, I72T, L89M, I93IM	A
Maguire (2002)	SW32381	SW32381	AY900671	APV	48	M46L, I54L		L10I, I13V, K20R, M36I, N37D, R41K, L63V, H69K	A
Holguin (2003)	SP_LP5	SP_LP5	AF455604	PI	NA			L10I, I13V, K14R, E35D, M36I, R41K, L63V, H69K, L89M	A
Montes (2004)	MB_patSAA	00_SAA713	AJ577989	NFV, SQV	21			L10I, I13V, I15V, E35D, M36I, R41K, H69K, L89M	A
		01_SAA704	AJ577990	NFV, SQV	21			L10I, I13V, I15V, E35D, M36I, R41K, H69K, L89M	A
Non-B Workgroup (2005)	UK1516	UK1516		PI, LPV	NA	I54L		L10I, I13V, G16E, K20T, E35D, M36I, R41K, R57K, L63T, H69K, T74S, V82VI, I85V, L89M	A
	IL276	IL276		IDV	81			L10I, E35D, M36I, R41K, R57K, L63T, H69R, L89M, I93L	A
	UK2149	UK2149	AY900859	Unknown, LPV	NA	M46I, L76V, I84V	L33I, N83D	L10I, I13V, A22V, E35D, M36I, N37D, R41K, K45R, R57K, L63P, A71V, L89I	A
	TK1001	TK1001		IDV	129			L10I, I13V, K14R, E35D, M36I, R41K, R57K, H69K, L89M	A
		TK1001a		IDV	179	V82A		L10I, I13V, K14R, E35D, M36I, R41K, R57K, H69K, L89I	A
	TK1030	TK1030		SQV, RTV, IDV	146			L10I, I13V, G16E, E35D, M36I, R41K, R57K, L63S, H69K, L89M	A
	TK2029	TK2029		IDV	39			L10I, I13V, K14R, G16GE, E35D, M36I, R41K, K45R, R57K, L63P, H69K, V77I, L89M	A
	TK5005	TK5005		SQV, IDV, RTV, NFV, LPV	180	G48V, I54T, V82A, L90M		L10I, I13V, K14R, G17D, K20R, E34N, E35D, M36I, R41K, R57K, D60E, I62V, L63P, H69K, A71V, L89I	A
		TK5005a		SQV, IDV, RTV, NFV, LPV	196	G48V, I54T, L90M		L10I, I13V, K14R, G17D, K20R, E34N, E35D, M36I, R41K, R57K, D60E, I62V, L63P, H69K, A71IV, L89I, I93IM	A
	TK5012	TK5012		IDV	54			L10I, I13V, K14R, G16E, K20R, E35D, M36I, R41K, L63T, H69K, L89M	A
		TK5012a		IDV, LPV	152			L10I, I13V, K14KR, G16E, K20R, E35D, M36I, R41K, L63T, H69K, L89M	A
		TK5012c		IDV, LPV	215			L10I, I13V, K14KR, G16E, K20R, D25DG, E35D, M36I, R41K, L63ST, H69K, L89M	A
	PL34031	55128		IDV, NFV	207	M46I, I84V	L89V	L10I, T12S, I13V, L19V, K20I, E35D, N37D, L63P, I66F, H69K, K70R, A71V	A
Weber (2005)	F45753	F45753	AY677422	SQV, NFV	258			L10I, I13V, G16E, K20R, E35D, M36I, P39S, R41K, H69K, L89M	A
	M50457	M50457	AY677433	NFV	94			L10I, T12S, I13V, K14KR, I15IV, K20I, E35D, M36I, N37S, R41K, K45R, H69K, A71V, L89T	A
	F87084	F87084	AY677406	IDV	28			L10I, I13V, K14R, G16E, E35D, M36I, R41K, R57K, L63V, H69K, L89M	A
	F78596	F78596	AY677480	IDV	18			L10I, I13V, I15L, K20I, E35D, M36I, L63S, H69K, L89M	A
	M47502	M47502	AY677409	NFV	51	N88NS		L10I, I13V, K20KT, E35ED, M36I, R41K, L63T, I64IV, H69K, L89M	A
	89M2626	89M2626	AY677414	SQV, NFV, RTV	261	I54V, L90M	F53L, L89V	L10I, I13V, K14R, K20I, E35D, M36I, N37E, R41K, R57K, H69K, A71V, T74S	A
Baxter (2006)	48-3316	3316-30818	DQ878217	PI	NA	I54A, V82F		L10I, T12TK, I13V, G16A, L19LV, K20I, E35N, M36I, R41K, D60E, L63P, H69K, T74S, V77I, L89M	A
	48-4186	4186-30408	DQ878420	PI	NA	I54V, V82A	L24I, L33I, Q58E, N83D	L10I, I13V, G16E, K20R, A22V, E35D, M36I, N37D, R41K, L63T, H69K, I72V, T74A, L89M, T91V, I93L	A
	48-4217	4217-30915	DQ878451	PI	NA	M46L, I54V, I84V, L90M	L33F, K43T, N88G	L10I, I13V, K14R, K20R, E21Q, E35D, M36I, N37D, Q61N, I62V, L63Q, H69K, A71L, T74S, Q92R, I93M	A
	48-5010	5010-30820	DQ878543	PI	NA	M46MIL, I54V, V82A	Q58E	L10I, I13V, K20KR, E35D, M36I, N37ND, R41K, I62V, L63P, A71T	A
	48-5021	5021-30606	DQ878555	PI	NA	I54V, V82F, I84IV, L90M	L33F, F53L	L10I, V11L, I13V, I15V, G16E, L19P, K20I, E35N, M36I, K45V, L63T, H69K, L89M	A
	48-8053	8053-30818	DQ879078	PI	NA	M46L, G48V, I54S, V82A	L33I, F53L	L10I, I13A, K14N, A22V, E35D, M36I, K55R, R57K, I62V, L63P, H69K, K70KR, T74S, L89I	A
Laurent (2006)	CK22-35	03CM2-35	AM279456	IDV	74	I54IV, V82A	L33LI	L10I, I13V, E35D, M36I, R41K, K45R, L63P, H69K, L89T	A
Tee (2006)	MYKL1855	04MYKL1855	AY960955	LPV		I54V, V82F	L33I, L89V	L10I, I13V, Q18H, A22V, E35D, M36I, N37D, H69K, A71V, I93M	A
Sylla (2008)	A2868	A2868_C1	EF525663	IDV				L10I, I13V, G16E, K20R, E35D, M36I, R41K, H69K, K70R, I72R, L89M	A
Koyalta (2009)	17	TCHAD-17	FJ688177	IDV	26	M46I, I84V		L10I, I13V, K14R, I15V, K20I, M36I, R41K, R57K, L63P, I66F, H69N, I72V, L89I	A
	33	TCHAD-33	FJ688184	IDV	26			L10I, I13V, G16A, K20I, E35D, M36I, R41K, H69Q, L89M	A
Thomson (2009)	SP_B_057	RU_SP_B_057	FJ009812	RTV, IDV, LPV	29			L10I, E35D, M36I, R41K, H69K, L89M	A
Barber (2012)	50857	50857	JQ361664	LPV		M46I, L76V, I84V		L10I, I13V, G16E, M36I, R41K, L63T, H69K, L89M	A
Jones (2012)	159797	159797	JN669961	PI	NA	M46I, I54V, L76V, V82A	L33LF	L10I, I13V, I15IV, G16E, K20M, E35D, M36I, R41K, K55R, R57K, Q61N, A71T, I72R, L89I	A
	184144	184144	JN670673	PI	NA	M46I, I50IL, I54AV, V82A	L24I, L33F, Q58E	L10I, T12N, I13V, G16GE, K20I, E35N, M36I, N37E, R41K, R57K, D60E, Q61N, L63T, I72T, L89M	A
	199883	199883	JN671186	PI	NA	M46I, I54V, V82A, L90M	N88D	L10I, I13V, I15V, L19I, K20I, E35D, M36I, N37K, R41K, K45R, K55R, R57K, Q61N, L63P, C67F, A71T, I72E	A

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