<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype A
Gene PR
Mutation L10I
Rx >= 1 PI
IncludeMixtures No
References 15
Patients 37
Isolates 42
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Yahi (2001)NY_M29M29AY010392IDV M46I, I54V, V82F L10I, I13V, I15V, K20KI, E35D, M36I, R41K, D60E, I62IV, H69Q, L89IA
 NY_M35M35AY010399NFV M46I, L90M L10I, I13V, K14R, G16E, K20I, E35DN, M36I, I62IV, L63S, C67D, H69R, I72T, L89M, I93IMA
Maguire (2002)SW32381SW32381AY900671APV48M46L, I54L L10I, I13V, K20R, M36I, N37D, R41K, L63V, H69KA
Holguin (2003)SP_LP5SP_LP5AF455604PINA  L10I, I13V, K14R, E35D, M36I, R41K, L63V, H69K, L89MA
Montes (2004)MB_patSAA00_SAA713AJ577989NFV, SQV21  L10I, I13V, I15V, E35D, M36I, R41K, H69K, L89MA
  01_SAA704AJ577990NFV, SQV21  L10I, I13V, I15V, E35D, M36I, R41K, H69K, L89MA
Non-B Workgroup (2005)UK1516UK1516 PI, LPVNAI54L L10I, I13V, G16E, K20T, E35D, M36I, R41K, R57K, L63T, H69K, T74S, V82VI, I85V, L89MA
 IL276IL276 IDV81  L10I, E35D, M36I, R41K, R57K, L63T, H69R, L89M, I93LA
 UK2149UK2149AY900859Unknown, LPVNAM46I, L76V, I84VL33I, N83DL10I, I13V, A22V, E35D, M36I, N37D, R41K, K45R, R57K, L63P, A71V, L89IA
 TK1001TK1001 IDV129  L10I, I13V, K14R, E35D, M36I, R41K, R57K, H69K, L89MA
  TK1001a IDV179V82A L10I, I13V, K14R, E35D, M36I, R41K, R57K, H69K, L89IA
 TK1030TK1030 SQV, RTV, IDV146  L10I, I13V, G16E, E35D, M36I, R41K, R57K, L63S, H69K, L89MA
 TK2029TK2029 IDV39  L10I, I13V, K14R, G16GE, E35D, M36I, R41K, K45R, R57K, L63P, H69K, V77I, L89MA
 TK5005TK5005 SQV, IDV, RTV, NFV, LPV180G48V, I54T, V82A, L90M L10I, I13V, K14R, G17D, K20R, E34N, E35D, M36I, R41K, R57K, D60E, I62V, L63P, H69K, A71V, L89IA
  TK5005a SQV, IDV, RTV, NFV, LPV196G48V, I54T, L90M L10I, I13V, K14R, G17D, K20R, E34N, E35D, M36I, R41K, R57K, D60E, I62V, L63P, H69K, A71IV, L89I, I93IMA
 TK5012TK5012 IDV54  L10I, I13V, K14R, G16E, K20R, E35D, M36I, R41K, L63T, H69K, L89MA
  TK5012a IDV, LPV152  L10I, I13V, K14KR, G16E, K20R, E35D, M36I, R41K, L63T, H69K, L89MA
  TK5012c IDV, LPV215  L10I, I13V, K14KR, G16E, K20R, D25DG, E35D, M36I, R41K, L63ST, H69K, L89MA
 PL3403155128 IDV, NFV207M46I, I84VL89VL10I, T12S, I13V, L19V, K20I, E35D, N37D, L63P, I66F, H69K, K70R, A71VA
Weber (2005)F45753F45753AY677422SQV, NFV258  L10I, I13V, G16E, K20R, E35D, M36I, P39S, R41K, H69K, L89MA
 M50457M50457AY677433NFV94  L10I, T12S, I13V, K14KR, I15IV, K20I, E35D, M36I, N37S, R41K, K45R, H69K, A71V, L89TA
 F87084F87084AY677406IDV28  L10I, I13V, K14R, G16E, E35D, M36I, R41K, R57K, L63V, H69K, L89MA
 F78596F78596AY677480IDV18  L10I, I13V, I15L, K20I, E35D, M36I, L63S, H69K, L89MA
 M47502M47502AY677409NFV51N88NS L10I, I13V, K20KT, E35ED, M36I, R41K, L63T, I64IV, H69K, L89MA
 89M262689M2626AY677414SQV, NFV, RTV261I54V, L90MF53L, L89VL10I, I13V, K14R, K20I, E35D, M36I, N37E, R41K, R57K, H69K, A71V, T74SA
Baxter (2006)48-33163316-30818DQ878217PINAI54A, V82F L10I, T12TK, I13V, G16A, L19LV, K20I, E35N, M36I, R41K, D60E, L63P, H69K, T74S, V77I, L89MA
 48-41864186-30408DQ878420PINAI54V, V82AL24I, L33I, Q58E, N83DL10I, I13V, G16E, K20R, A22V, E35D, M36I, N37D, R41K, L63T, H69K, I72V, T74A, L89M, T91V, I93LA
 48-42174217-30915DQ878451PINAM46L, I54V, I84V, L90ML33F, K43T, N88GL10I, I13V, K14R, K20R, E21Q, E35D, M36I, N37D, Q61N, I62V, L63Q, H69K, A71L, T74S, Q92R, I93MA
 48-50105010-30820DQ878543PINAM46MIL, I54V, V82AQ58EL10I, I13V, K20KR, E35D, M36I, N37ND, R41K, I62V, L63P, A71TA
 48-50215021-30606DQ878555PINAI54V, V82F, I84IV, L90ML33F, F53LL10I, V11L, I13V, I15V, G16E, L19P, K20I, E35N, M36I, K45V, L63T, H69K, L89MA
 48-80538053-30818DQ879078PINAM46L, G48V, I54S, V82AL33I, F53LL10I, I13A, K14N, A22V, E35D, M36I, K55R, R57K, I62V, L63P, H69K, K70KR, T74S, L89IA
Laurent (2006)CK22-3503CM2-35AM279456IDV74I54IV, V82AL33LIL10I, I13V, E35D, M36I, R41K, K45R, L63P, H69K, L89TA
Tee (2006)MYKL185504MYKL1855AY960955LPV I54V, V82FL33I, L89VL10I, I13V, Q18H, A22V, E35D, M36I, N37D, H69K, A71V, I93MA
Sylla (2008)A2868A2868_C1EF525663IDV   L10I, I13V, G16E, K20R, E35D, M36I, R41K, H69K, K70R, I72R, L89MA
Koyalta (2009)17TCHAD-17FJ688177IDV26M46I, I84V L10I, I13V, K14R, I15V, K20I, M36I, R41K, R57K, L63P, I66F, H69N, I72V, L89IA
 33TCHAD-33FJ688184IDV26  L10I, I13V, G16A, K20I, E35D, M36I, R41K, H69Q, L89MA
Thomson (2009)SP_B_057RU_SP_B_057FJ009812RTV, IDV, LPV29  L10I, E35D, M36I, R41K, H69K, L89MA
Barber (2012)5085750857JQ361664LPV M46I, L76V, I84V L10I, I13V, G16E, M36I, R41K, L63T, H69K, L89MA
El Annaz (2012)13281328.PRJN185236PINA  L10I, I13V, E21Q, E35D, M36I, R41K, H69K, L89MA
Jones (2012)159797159797JN669961PINAM46I, I54V, L76V, V82AL33LFL10I, I13V, I15IV, G16E, K20M, E35D, M36I, R41K, K55R, R57K, Q61N, A71T, I72R, L89IA
 184144184144JN670673PINAM46I, I50IL, I54AV, V82AL24I, L33F, Q58EL10I, T12N, I13V, G16GE, K20I, E35N, M36I, N37E, R41K, R57K, D60E, Q61N, L63T, I72T, L89MA
 199883199883JN671186PINAM46I, I54V, V82A, L90MN88DL10I, I13V, I15V, L19I, K20I, E35D, M36I, N37K, R41K, K45R, K55R, R57K, Q61N, L63P, C67F, A71T, I72EA