Protease Inhibitors

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Protease Inhibitors

Subtype	A
Gene	PR
Mutation	L10F
Rx	>= 1 PI
IncludeMixtures	No

References	7
Patients	13
Isolates	15

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	PIs	Wks	PIMajorDRMs	PIMinorDRMs	OtherMut	Subtype
Montes (2004)	MB_patMUZ	00_MUZ714	AJ577959	NFV	18		L10F	I13V, E35D, M36I, R41K, R57K, H69K, L89I	A
Non-B Workgroup (2005)	TK1010	TK1010a		IDV, Unknown	>229		L10F	T12I, I13V, G16E, E35D, M36I, R41K, R57K, H69K, K70R, L89M	A
		TK1010b		IDV, Unknown	>229		L10F	T12I, I13V, G16E, E35D, M36I, R41K, R57K, I62V, L63H, H69K, K70R, L89M	A
	TK4006	TK4006		NFV	83	N88S	L10F	I13V, I15V, K20I, E35N, M36I, R41K, K45R, R57Q, H69K, L89I	A
	TK5002	TK5002		NFV	189	N88S	L10F	I13V, K14R, I15V, K20T, E35D, M36I, R41K, K45R, R57K, H69K, L89I	A
Weber (2005)	M41971	M41971	AY677401	IDV, NFV, LPV	181	I54V, V82A	L10F, L33I	T4TS, I13V, G16E, L19LI, K20R, E35D, M36I, N37D, R41K, K45V, K55T, R57K, L63H, H69K, K70R, L89M, T91TS	A
Baxter (2006)	12-2120	2120-30715	DQ876783	PI	NA	M46I, I47V, L90M	L10F, L33I, F53L, G73GS, N88G, L89V	I13V, K14R, K20T, E35D, M36I, R41K, R57K, I62V, L63P, H69K, A71I	A
		2120-40510	DQ876754	PI, RTV, TPV	>43	M46I, I47V, L90M	L10F, L33I, F53L, G73S, N88G, L89V	I13V, K14R, K20T, E35D, M36I, R41K, R57K, I62V, L63P, H69K, A71I	A
	48-4018	4018-30227	DQ878252	PI	NA	M46I	L10F, V11I, L24I, L33F, Q58E, T74P	T12TA, I13V, E35D, M36IV, N37D, I62V, L63T, H69K, K70R, I85V, L89M	A
	48-4153	4153-30326	DQ878387	PI	NA	M46I, I54L, L76V, I84V	L10F	I13V, G16E, K20I, L33L_L, E35D, M36I, R57K, Q61R, L63T, H69K, L89I, T91TS	A
	48-5032	5032-30421	DQ878558	PI	NA	I54V, L90M	L10F, L33I, L89V	I13V, E35D, M36I, R41K, R57K, I62IV, L63LP, H69K	A
Dau (2010)	11741A	11741A	GU582052	PI	NA	N88S	L10F, L89V	I13V, K20T, E35D, M36I, R41K, I62V, L63P, H69K, T74S	A
Barber (2012)	48826	48826	JQ361679	LPV		V32I, M46I, I47A	L10F, L33I, L89V	I13V, K20R, E35D, M36I, R41K, R57K, I62V, H69K, K70R, T74S	A
Jones (2012)	160444	160444	JN669977	PI	NA	I54IV	L10F, F53FL	I13V, E35D, M36I, N37D, R41K, L63V, H69K, K70R, T74A, L89M, T91V	A
	178278	178278	JN670478	PI	NA	I54V, V82VA, L90LM	L10F, F53L	I13V, K20I, E35D, M36I, N37D, R41K, I62V, L63V, H69K, K70R, T74A, L89M, T91V	A

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