<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype F
Gene RT
Mutation M41L
Rx >= 1 NRTI
(but no NNRTI)
IncludeMixtures No
References 11
Patients 24
Isolates 25
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Orlandi (1998)PO-Pt2Orl2-W56AF056640AZTNoneM41L, T215Y V35T, I135V, S162C, E169D, K173I, Q174K, V179I, Q207E, R211KF
  Orl2-W80AF056641AZTNoneM41L, T215Y V35T, I135V, S162C, E169D, K173I, Q174K, V179I, Q207E, R211KF
Yahi (2001)NY_M43M43AY010454D4T, DDINoneM41L, T215Y K32I, V35T, K49R, D123E, I135T, S162C, E169D, K173A, Q174R, D177E, Q207E, R211KF
Brindeiro (2002)TVGG13TVGG13AY145824AZT, 3TCNoneM41L, M184V, T215Y V35M, I135V, S162C, E169A, K173A, Q174K, Q207E, R211Q, V245Q, E248D, A272P, E291D, V292I, I293VF
 TVGG18TVGG18AY145826AZT, 3TCNoneM41L, M184V, T215F K20R, V35T, T39A, E40D, K49R, I135V, E169D, K173T, Q174R, I178L, T200A, Q207E, H208Y, R211K, V245Q, E248D, A272P, K277R, T286A, A288T, E291D, V292I, I293V, E297V, S322TF
 TVSP1TVSP1AY145830AZT, 3TC, D4TNoneM41L, M184V, T215F K22N, V35T, E44K, I135V, S162C, E169A, K173A, Q174K, Q207E, R211K, V245Q, E248D, A272P, T286A, V292I, I293V, E297TF
Apetrei (2003)AC_Pat4RO.00.IS.04AY333562AZT, 3TC, D4TNoneM41L, T215C V35I, T39A, E40D, D123E, I135L, K173T, Q174K, D177E, T200E, Q207A, R211KF
Dumans (2004)RG046RG046AY390209AZT, 3TC, D4TNoneM41L, D67DE, L74I, M184V, T215Y V35T, T39TA, K43Q, S68SG, V118VI, K122KE, I135V, S162X, E169D, K173A, Q174K, I178L, Q207A, H208Y, R211K, P243S, A272P, K277R, T286A, E291D, V292I, I293V, E297AF
 223223AY390175AZT, DDI, 3TCNoneM41L, D67N, M184I, L210W, T215CY181VE44D, V118I, D123E, I135V, S162C, K173A, Q174K, N175Y, V179I, T200A, E203K, Q207E, H208Y, R211KF
 194194AY390186AZT, DDINoneM41L, L210W, T215Y T39K, K43E, K49R, I135V, S162C, E169D, K173A, Q174K, R211KF
Machado (2004)cs121cs121AY313411AZT, DDINoneM41L, D67N, T69D, K70R, T215F K49R, K122E, S162C, K173T, Q174K, D177E, I178L, Q207E, R211KF
 cs138cs138AY313417AZT, DDINoneM41L, D67N, K70R, T215Y, K219E T39K, V60I, K102Q, D123E, S162C, E169D, K173A, Q174K, Q207E, R211K, K220NF
 cs150cs150AY313420AZT, DDINoneM41L, D67N, L210W, T215Y T39R, K43E, E44D, K49R, S162C, E169D, Q174K, Q207E, R211KF
 cs190cs190AY313396AZT, DDI, D4T, 3TCNoneM41L, M184V, T215Y V118I, D123E, I135T, K166R, E169D, K173A, Q174K, Q207E, R211K, F214LF
Montes (2004)MB_patTOM01_TOM706AJ578169D4T, DDINoneM41L, T215Y V35T, T39A, K64H, V118I, D123E, I135L, S162H, K173T, Q174K, I195L, T200A, Q207A, R211K, L228RF
Non-B Workgroup (2005)PL4051769351 AZT, 3TC, D4T, DDINoneM41L, D67N, K70R, T215F, K219Q V35T, V60I, D123E, S162C, E169D, K173A, Q174K, I178L, E203D, Q207E, R211K, D218E, K223Q, L228H, V245Q, E248D, A272P, E291D, V292I, I293V, P294T, E297T, S322T, I329LF
Rodrigues (2005)BR0274502AY643224AZT, DDI, 3TC, D4TNoneM41L, V75M, M184V, L210W, T215Y P4S, V35T, T39L, E44D, V90I, V118I, K122E, I135V, S162Y, E169D, K173A, Q174K, Q207E, R211K, V245Q, E248D, A272P, K277R, T286A, E291D, V292I, I293V, E297T, V317AF
 BR01380397AY643263AZT, DDINoneM41L, D67N, K70R, T215Y, K219Q E28D, V35I, T39A, I135L, S162C, E169D, K173A, Q174K, I178L, T200A, Q207E, H208Y, R211KF
 BLF_Pat12BR03SP110AY643231AZT, 3TC, D4TNoneM41L, M184V, T215FY V35T, K49R, K102Q, V118VI, K122E, I135V, S162C, E169A, F171Y, K173A, Q174K, N175Y, Q207E, R211K, L228LR, V245Q, E248D, A272P, K277R, T286A, E291D, V292I, I293V, E297TF
 BLF_Pat16BR03SP111AY643232AZT, DDI, 3TCNoneM41L, D67N, K70R, M184V, T215Y, K219E V35MT, K43E, E44A, T107S, L109I, D123E, S162C, K173A, Q174K, D177E, T200A, E203D, Q207D, H208Y, R211K, W212L, H221Y, L228H, V245Q, E248D, S251D, A272P, T286A, E291D, V292I, I293V, E297T, V317A, Q334CF
 BLF_Pat34BR02SP220AY643214AZT, DDINoneM41L, L210W, T215Y E6N, K20R, V35T, S162H, E169D, K173T, Q174K, Q207E, R211K, L228LR, V245Q, E248DN, A272P, V276VI, T286A, E291D, V292I, I293V, P294S, E297A, G333GEF
 BLF_Pat35BR03SP71AY643250DDC, AZT, 3TC, D4TNoneM41L, M184V, L210W, T215Y E6A, K20R, V35T, T39Q, E44D, K122E, I135V, S162C, E169D, K173A, Q174K, I178L, Q207E, R211K, V245Q, E248D, A272P, K277R, T286A, E291D, V292I, I293V, P294T, E297AF
Dumans (2009)RENA463RENA463FJ405129AZT, 3TC, D4T, DDINoneM41L, T215F V35T, V118I, K173T, Q174K, Q207E, R211K, V245Q, E248D, D250S, K281R, T286A, I293V, E297KF
 75PR75PRFJ405164AZT, 3TCNoneM41L, D67N, L74I, L210W, T215F, K219W P4S, V35T, T39M, K43Q, S162C, E169D, K173A, Q174K, I178L, I202V, Q207E, H208Y, R211K, K223Q, L228RF
von Wyl (2010)18015601801560GQ848114AZT, 3TCNoneM41L, D67N, M184V, L210W, T215Y V35T, T39A, K43KE, E44D, V118VI, D123E, I135V, S162C, E169A, K173S, Q174K, G196GE, E203K, Q207D, R211K, V245Q, E248D, A272P, K275R, T286A, E291D, V292I, I293V, E297T, V317A, R356K, M357I, G359S, T377V, Q394L, K395R, E399DF