<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype F
Gene RT
Mutation E40D
Rx >= 1 NRTI
(but no NNRTI)
IncludeMixtures No
References 8
Patients 15
Isolates 16
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Balotta (2000)CB-231CB-231AF252092DDC, AZT, 3TCNoneK70R, M184V, K219Q V35T, E40D, T69N, D123E, I135L, S162W, K166R, K173A, Q174K, V179I, T200A, Q207G, R211K, V245QF
Brindeiro (2002)TVGG18TVGG18AY145826AZT, 3TCNoneM41L, M184V, T215F K20R, V35T, T39A, E40D, K49R, I135V, E169D, K173T, Q174R, I178L, T200A, Q207E, H208Y, R211K, V245Q, E248D, A272P, K277R, T286A, A288T, E291D, V292I, I293V, E297V, S322TF
 TVSP21TVSP21AY901445AZT, DDI, 3TC, D4TNoneM184V V35T, T39N, E40D, D123E, E169D, K173A, Q174K, Q207E, H208Y, R211K, V245Q, E248D, A272P, V276T, T286A, E291D, V292I, I293V, P294T, E297A, D324EF
Gibb (2002)DMG6464_w26 ABC, 3TCNoneM184V E6EK, V35T, T39A, E40D, Y56YC, W88C, D123E, I135L, S162Y, K173T, Q174K, I178L, I195L, T200A, Q207T, R211K, V245Q, E248N, A272P, A288S, E291D, V292I, I293V, P294T, E297T, I329V, P345T, R356K, G359S, T377M, S379CF
 DMG8686_w25 AZT, 3TCNone  K22R, V35T, E40D, D123E, I135L, S162H, K173T, Q174K, I195L, T200A, Q207A, R211K, V245Q, E248D, A272P, T286A, E291D, V292I, I293V, P294PT, E297A, V317A, S322T, I326V, P345AT, F346Y, R356K, G359S, T377M, S379CF
Maxeiner (2002)700053f700053f+ D4TNone  K20KR, V35T, T39A, E40D, V60VI, D123E, I135L, S162H, K173T, Q174K, I195IL, T200A, Q207A, R211K, V245Q, E248D, A272P, T286A, E291D, V292I, I293V, P294T, E297A, P345T, R356K, G359S, K366KR, T377M, S379C, K395KR, E399D, K431T, V435T, A446S, K451R, L452Q, V466A, D471E, T477A, H483HQ, L491S, S519N, K527Q, K530R, V531I, A534S, K550R, A554AT, V559IF
Apetrei (2003)AC_Pat3RO.00.IS.03AY333560AZT, 3TCNone K103NV35T, T39A, E40D, K122E, D123G, I135L, S162H, K173T, Q174K, I195L, T200A, Q207A, R211KF
 AC_Pat4RO.00.IS.04AY333562AZT, 3TC, D4TNoneM41L, T215C V35I, T39A, E40D, D123E, I135L, K173T, Q174K, D177E, T200E, Q207A, R211KF
 AC_Pat21RO.00.IS.21AY333610AZT, 3TCNoneK70R V35T, T39A, E40D, K49R, D123E, I135L, S162Y, E169A, K173A, Q174K, I178M, I195L, Q207E, R211KF
  RO.01.IS.21AY333611AZT, 3TCNoneK70R V35T, T39A, E40D, K49R, E53G, D123E, I135L, S162Y, E169A, K173T, Q174K, I195L, Q207E, R211KF
 AC_Pat32RO.00.IS.32AY333566AZT, 3TCNone  V35T, T39A, E40D, T69S, D123E, I135L, S162H, K173T, Q174K, T200A, Q207A, R211KF
 AC_Pat33RO.00.IS.33AY333531AZT, 3TCNone  V35T, T39A, E40D, D123E, I135L, S162H, K173T, Q174K, D177E, T200A, Q207A, R211KF
 AC_Pat45RO.00.IS.45AY333585AZT, 3TCNoneK70R, M184V V35T, T39A, E40D, E53G, D123E, I135L, S162H, K166R, K173A, Q174R, I195L, T200A, Q207A, R211KF
Machado (2004)cs126cs126AY313376AZT, DDI, 3TCNoneD67N, K70R, M184V E40D, K49R, I135V, S162C, E169D, K173A, Q174K, I178L, T200A, E203K, Q207E, R211AF
von Wyl (2007)1345191462EF449882NRTINone  V35T, E36D, T39A, E40D, I135V, S162C, K173I, Q174K, T200A, Q207E, R211KF
Ferreira (2010)p022Dip022GQ862327AZTNone  V21I, V35T, T39K, E40D, K49R, V60I, I135V, S162C, E169D, K173V, Q174K, T200A, Q207A, R211K, V245Q, E248D, A272P, K281R, T286A, E291D, V292I, I293V, E297A, A327VF