<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype F
Gene RT
Mutation M184V
Rx >= 1 NRTI
(but no NNRTI)
IncludeMixtures No
References 16
Patients 39
Isolates 42
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Balotta (2000)CB-231CB-231AF252092DDC, AZT, 3TCNoneK70R, M184V, K219Q V35T, E40D, T69N, D123E, I135L, S162W, K166R, K173A, Q174K, V179I, T200A, Q207G, R211K, V245QF
Brindeiro (2002)TVGG13TVGG13AY145824AZT, 3TCNoneM41L, M184V, T215Y V35M, I135V, S162C, E169A, K173A, Q174K, Q207E, R211Q, V245Q, E248D, A272P, E291D, V292I, I293VF
 TVGG18TVGG18AY145826AZT, 3TCNoneM41L, M184V, T215F K20R, V35T, T39A, E40D, K49R, I135V, E169D, K173T, Q174R, I178L, T200A, Q207E, H208Y, R211K, V245Q, E248D, A272P, K277R, T286A, A288T, E291D, V292I, I293V, E297V, S322TF
 TVGG21TVGG21AY145827AZT, DDI, 3TC, D4TNoneM184V, T215F E6N, V35T, S68G, V118I, K122E, K173I, Q174K, Q207E, R211K, F214L, V245Q, T253S, A272P, T286A, E291D, V292I, I293V, P294T, E297AF
 TVSP1TVSP1AY145830AZT, 3TC, D4TNoneM41L, M184V, T215F K22N, V35T, E44K, I135V, S162C, E169A, K173A, Q174K, Q207E, R211K, V245Q, E248D, A272P, T286A, V292I, I293V, E297TF
 TVSP21TVSP21AY901445AZT, DDI, 3TC, D4TNoneM184V V35T, T39N, E40D, D123E, E169D, K173A, Q174K, Q207E, H208Y, R211K, V245Q, E248D, A272P, V276T, T286A, E291D, V292I, I293V, P294T, E297A, D324EF
 TVSP16TVSP16AY145813AZT, 3TC, D4TNoneD67N, K70R, M184V, K219Q V35K, K102R, D123E, I135L, S162W, E169D, K173A, Q174K, D177E, I178V, S191T, T200A, E203K, Q207E, R211K, F214L, V245Q, A272P, T286P, E291D, V292I, I293V, E297TF
Gibb (2002)DMG6464_w26 ABC, 3TCNoneM184V E6EK, V35T, T39A, E40D, Y56YC, W88C, D123E, I135L, S162Y, K173T, Q174K, I178L, I195L, T200A, Q207T, R211K, V245Q, E248N, A272P, A288S, E291D, V292I, I293V, P294T, E297T, I329V, P345T, R356K, G359S, T377M, S379CF
Apetrei (2003)AC_Pat45RO.00.IS.45AY333585AZT, 3TCNoneK70R, M184V V35T, T39A, E40D, E53G, D123E, I135L, S162H, K166R, K173A, Q174R, I195L, T200A, Q207A, R211KF
Dumans (2004)RG046RG046AY390209AZT, 3TC, D4TNoneM41L, D67DE, L74I, M184V, T215Y V35T, T39TA, K43Q, S68SG, V118VI, K122KE, I135V, S162X, E169D, K173A, Q174K, I178L, Q207A, H208Y, R211K, P243S, A272P, K277R, T286A, E291D, V292I, I293V, E297AF
Kuritzkes (2004)KDR_pat192A0261AY528078D4T, 3TCNoneM184V T39A, K122KR, D123E, I135L, I142S, S162Y, K173R, D192N, Q207A, R211KF
  A0262AY528079D4T, 3TCNoneM184V T39A, V90VI, K122KR, D123E, I135L, I142S, S162HY, K173R, Q207A, R211KF
  A0263AY528080D4T, 3TCNoneM184V T39A, V90VI, K122KR, D123E, I135L, I142S, G152D, W153R, S162HY, K173R, Q207A, R211KF
  A0264AY528081D4T, 3TCNoneM184V T39A, V90VI, K122KR, D123E, I135L, I142S, S162HY, K173R, Q207A, R211KF
Machado (2004)CS257CS257AY569970AZT, DDI, 3TCNoneD67N, K70R, M184V D121A, K122E, I135V, S162C, K173T, Q174K, D177E, I178L, T200A, Q207E, R211K, F214LF
Machado (2004)cs126cs126AY313376AZT, DDI, 3TCNoneD67N, K70R, M184V E40D, K49R, I135V, S162C, E169D, K173A, Q174K, I178L, T200A, E203K, Q207E, R211AF
 cs128cs128AY313378AZT, DDI, 3TCNoneD67N, T69D, K70R, M184V, T215F, K219Q K49R, I135V, S162C, E169D, K173A, Q174K, I178L, T200A, R211AF
 cs139cs139AY313418AZT, DDI, 3TCNoneD67N, K70R, M184V, T215V T39M, I47F, V60I, T69A, V90I, K122E, I135L, S162H, K173T, Q174K, G196E, R211KF
 cs190cs190AY313396AZT, DDI, D4T, 3TCNoneM41L, M184V, T215Y V118I, D123E, I135T, K166R, E169D, K173A, Q174K, Q207E, R211K, F214LF
Montes (2004)MB_patBAR99_BAR710AJ577733AZT, DDI, 3TCNoneM184V, T215F V35T, K49R, I135L, S162C, E169D, K173A, Q174K, Q207E, R211K, T240AF
Delaunay (2005)DC_01111_1005w12DQ286507ABC, TDF, 3TCNoneK65R, M184V V35T, D123E, K173A, Q174K, D177E, I178M, T200A, Q207A, R211SF
Rodrigues (2005)BR0274502AY643224AZT, DDI, 3TC, D4TNoneM41L, V75M, M184V, L210W, T215Y P4S, V35T, T39L, E44D, V90I, V118I, K122E, I135V, S162Y, E169D, K173A, Q174K, Q207E, R211K, V245Q, E248D, A272P, K277R, T286A, E291D, V292I, I293V, E297T, V317AF
 BLF_Pat12BR03SP110AY643231AZT, 3TC, D4TNoneM41L, M184V, T215FY V35T, K49R, K102Q, V118VI, K122E, I135V, S162C, E169A, F171Y, K173A, Q174K, N175Y, Q207E, R211K, L228LR, V245Q, E248D, A272P, K277R, T286A, E291D, V292I, I293V, E297TF
 BLF_Pat13BR03SP64AY643249AZT, 3TCNoneM184V E28L, E29N, V35T, T39L, V60I, I135V, S162C, E169D, K173A, Q174K, T200A, R211KF
 BLF_Pat16BR03SP111AY643232AZT, DDI, 3TCNoneM41L, D67N, K70R, M184V, T215Y, K219E V35MT, K43E, E44A, T107S, L109I, D123E, S162C, K173A, Q174K, D177E, T200A, E203D, Q207D, H208Y, R211K, W212L, H221Y, L228H, V245Q, E248D, S251D, A272P, T286A, E291D, V292I, I293V, E297T, V317A, Q334CF
 BLF_Pat19BR02SP234AY643216AZT, DDI, 3TC, D4TNoneM184V E6D, K20R, E28A, V35T, T39E, D123E, I135V, I142IV, S162C, E169D, K173A, Q174K, I178L, T200A, Q207E, R211K, V245Q, E248N, A272P, K277R, T286A, E291D, V292I, I293V, P294S, E297K, A304EF
 BLF_Pat25BR02SP184AY6432133TC, D4T, AZT, DDINoneM184V S3R, E6D, E28K, K32E, V35T, T39M, K49R, I135V, S162C, E169D, K173A, Q174K, I178L, T200K, E203D, Q207A, R211Q, V245Q, E248D, A272P, K277R, T286A, V292I, I293V, E297T, I329LF
 BLF_Pat27BR03SP155AY643236AZT, DDINoneM184V K20R, V35T, T39M, K122E, I135V, E138A, S162C, K173A, Q174R, G196E, Q207D, R211K, F214L, V245Q, E248D, D250E, A272P, V276I, T286A, E291D, V292I, I293V, P294T, E297T, I329LF
 BLF_Pat28BR02SP258AY6432213TC, D4TNoneA62V, M184V V35T, D123DE, I135V, S162C, E169D, K173A, Q174K, I178L, V179VI, Q207D, L210M, R211K, V245Q, E248D, S251SI, A272P, K275Q, T286A, E291D, V292I, I293V, E297A, S322A, D324E, Q334HF
 BLF_Pat35BR03SP71AY643250DDC, AZT, 3TC, D4TNoneM41L, M184V, L210W, T215Y E6A, K20R, V35T, T39Q, E44D, K122E, I135V, S162C, E169D, K173A, Q174K, I178L, Q207E, R211K, V245Q, E248D, A272P, K277R, T286A, E291D, V292I, I293V, P294T, E297AF
 BLF_Pat40BR02SP226AY6432153TC, D4TNoneM184V V21VI, V35T, T39A, K49R, D123E, I135V, S162C, E169D, K173A, Q174K, D177E, Q207E, R211K, V245Q, E248D, A272P, T286A, E291D, V292I, I293V, E297TF
von Wyl (2007)1091789954EF449996NRTINoneM184V E6K, V35T, E36D, K122E, I135V, S162C, E169D, K173I, Q174K, Q207A, R211KF
 15496611EF449962NRTINoneM184V V35T, V60I, K122P, I135V, K173T, Q174K, D177E, G196E, T200N, Q207E, F214LF
 81496899EF450023NRTINoneA62V, M184V V35T, S48SA, D123E, I142V, K173A, Q174K, N175Y, D177E, I178IV, Q207EF
Dumans (2009)RENA651RENA651FJ405167AZT, 3TC, DDI, D4TNoneM184V V35T, T39M, I135V, S162C, E169A, K173A, Q174K, Q207E, R211K, T216TS, V245Q, E248D, A272P, T286A, V292I, I293V, E297AF
 RENA140RENA140FJ405170AZT, 3TCNoneD67N, K70R, M184V, T215FY, K219E E28K, V35T, K122Q, I135V, S162C, E169D, K173T, Q174K, I178L, T200A, I202V, Q207A, R211Q, V245Q, E248D, A272P, T286A, A288T, E291D, V292I, I293V, E297A, I329LF
 RENA780RENA780FJ405171AZT, 3TCNoneM184V V35T, K122P, I135L, S162C, K173T, Q174K, I178L, T200A, Q207K, R211T, V245Q, E248D, A272P, T286A, V292I, I293V, P294T, E297AF
 RENA390RENA390FJ405175AZT, DDI, 3TCNoneK70R, M184V V35T, T39N, K122E, D123E, S162C, E169D, K173A, Q174K, D177E, I178L, T200A, Q207E, R211K, V245Q, E248D, A272P, K277R, T286A, E291D, V292I, I293V, E297AF
 RENA332RENA332FJ405177AZT, 3TC, D4T, DDINoneD67N, K70R, M184V, K219EQV179D, Y181CK20R, V90I, K102Q, K103R, D123E, I135V, S162C, E169D, K173A, Q174K, T200A, Q207E, R211K, F214L, V245Q, E248D, A272P, A288T, E291D, V292I, I293V, E297A, V317AF
Koyalta (2009)17TCHAD-17FJ688177D4T, 3TCNoneM184V V60I, D123E, I135V, K173A, Q174A, D177E, I178L, V179I, Q207E, R211KF
Rodrigues (2010)339_07BR07SC339GQ401327AZT, 3TCNoneM184VK103N, V108VIK20KR, V35T, T39L, V90I, S162Y, F171Y, K173T, Q174K, E203D, Q207E, R211K, F214LF
von Wyl (2010)18015601801560GQ848114AZT, 3TCNoneM41L, D67N, M184V, L210W, T215Y V35T, T39A, K43KE, E44D, V118VI, D123E, I135V, S162C, E169A, K173S, Q174K, G196GE, E203K, Q207D, R211K, V245Q, E248D, A272P, K275R, T286A, E291D, V292I, I293V, E297T, V317A, R356K, M357I, G359S, T377V, Q394L, K395R, E399DF