<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype D
Gene RT
Mutation K70R
Rx >= 1 NRTI
(but no NNRTI)
IncludeMixtures No
References 7
Patients 8
Isolates 8
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Carr (1999)SE7108SE7108AF071473AZT, DDINoneD67N, K70R, T215Y, K219Q V35T, V60I, D121H, K122E, D123E, I135T, K173S, Q174K, D177E, I178L, V179I, T200I, Q207E, R211K, K238R, V245K, D250E, L282C, T286A, V292I, I293V, G335D, T338S, P345Q, F346Y, R356K, M357L, A360T, V365I, E370A, T377Q, S379C, K390R, A400T, E432D, V435A, A437V, V458I, H483N, L491P, K512R, S519N, Q524K, K527G, E529D, A534S, A554SD
Cuevas (2002)CU71CU71AF425452AZTNoneK70R, T215E V35T, T39A, E40D, K49R, V60I, K122E, S162C, E169D, D177E, Q207ED
Non-B Workgroup (2005)UK1392UK1392AY901334AZT, 3TCNoneD67N, K70R, M184V, K219Q V35T, K49R, V60I, D121Y, K122E, D123E, T139R, I159V, D177E, I178M, T200I, Q207E, R211KD
 TK4018TK4018 AZT, 3TC, D4TNoneD67N, K70R, M184V, T215TS, K219Q V35I, I47L, V60I, T69TA, K103R, D121H, K122E, I135T, D177E, T200I, Q207E, R211K, V245K, D250DE, S251I, A272S, L282C, T286A, I293VD
Weber (2005)F86075F86075AY677601ABC, AZT, 3TCNoneD67N, K70R, M184V, T215Y V21VI, V35T, E40D, K49R, I50V, V60I, K101KQ, K122E, E169D, Q207E, V245K, D250E, A272PD
Koyalta (2009)8TCHAD-8FJ688175D4T, 3TCNoneD67N, K70R, M184V, K219E V60I, V106I, V118I, T139S, T165I, D177E, I178L, K201R, E204K, Q207E, R211K, F214LD
Ndembi (2010)16735D_P116735GQ409589ABC, AZT, 3TC, D4TNoneK65R, K70R, V75I, F116Y, Q151M, M184V V35T, K43R, V60I, S68G, D121H, K122E, K173S, Q174K, D177E, I178M, T200M, Q207E, R211K, F214LD
von Wyl (2010)47967344796734GQ848131AZT, 3TCNoneM41L, D67N, K70R, M184V, L210W, T215Y, K219E V35T, V60I, K101R, K122E, D123N, I135T, K166R, D177E, E203K, Q207E, R211K, V245K, D250E, A272P, Q334D, Y342F, M357A, T369A, S379G, K385R, K390R, K395R, A400TD