<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype D
Gene RT
Mutation S68G
Rx RTI-naive
IncludeMixtures No
References 16
Patients 29
Isolates 29
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Cuevas (2002)CU29CU29AF425410NoneNone  V8I, V35T, T39A, E40D, K49R, V60I, S68G, K122E, I135V, T139A, E169D, D177E, Q207ED
Richard (2004)RN_Pat15RNJLT15AAY556799NoneNone  K43R, V60I, S68G, K122E, I142V, D177E, I178LD
Church (2007)578-131089x578EF612071NoneNone  E6D, K11Q, V35T, K49R, V60I, S68G, D121Y, K122E, I159V, D177E, T200I, Q207G, R211K, V245N, D250E, A272P, K277R, L282C, T286A, I293VD
Aghokeng (2009)DG0405DG0405GU191645NoneNone  V35T, T39K, K49R, I50V, V60I, S68G, V106I, D123E, I135T, S162C, R172K, K173R, D177E, I178L, E204K, Q207E, F214L, V245T, D250E, A272P, K277R, T286A, I293V, E297K, D324E, I329V, Y339W, A376S, K390R, T403MD
Eshleman (2009)E23593W107-156889FJ389057NoneNone  V8VI, V35K, K49R, V60I, S68G, V118VI, I159V, D177E, T200I, Q207E, R211K, V245T, D250E, K281KR, L282C, T286AD
 J22380W208-101535FJ389116NoneNone  E6EK, V35T, K49R, V60I, S68G, D121Y, K122E, D177E, I178M, Q207G, R211K, V245K, D250E, A272P, K277R, L282C, L283I, T286A, I293VD
 C03294W308-102651FJ389142NoneNone  K32R, V35T, K49R, V60I, S68G, K122E, D123N, I159V, E169D, D177E, I178L, T200I, Q207D, R211K, P243S, V245E, D250E, A272P, L282C, L283I, R284K, T286A, I293VD
Castelbranco (2010)090014A090014AHM357731NoneNone  T39A, V60I, S68G, V106I, V118M, D121Y, K122E, I135T, T165IV, E169D, D177E, I178V, G196GE, T200A, I202V, E204K, Q207E, R211K, F214L, V245TD
Towler (2010)324558-C324558-CHM037845NoneNone  K20KR, V35MT, T39A, K49R, V60I, S68G, W88C, D121Y, K122E, R125K, I135T, D177E, Q207N, R211K, F214FL, I244V, V245K, D250E, A272P, K277R, L282C, T286A, I293V, G316*D
Hamers (2011)CP076301798CP076301798HQ994975NoneNone K101EV35I, K49R, V60I, S68G, D121Y, K122E, I159V, D177E, Q207E, R211K, V245E, D250E, A272P, K277R, L282C, L283LI, T286A, I293V, E297AD
 CP076302082CP076302082HQ995036NoneNone  V35T, T39R, K43KE, K49R, V60I, S68G, V90VI, K102Q, D121Y, K122E, I135T, I142IV, T165I, R172K, D177E, I178M, E204K, Q207E, R211RK, V245L, D250E, S251IT, A272P, K281R, T286AD
 CP076300880CP076300880HQ995134NoneNone  V35I, K49R, V60I, S68G, D121HY, K122E, I135KT, E138A, I180V, T200IM, Q207G, R211K, V245K, D250E, L282C, L283I, T286A, I293VD
 CP076300736CP076300736HQ995325NoneNone  I5V, V35T, T39E, K49R, V60I, S68G, D121Y, K122E, D177E, I178M, Q207E, R211K, V245N, D250E, A272S, L283LI, T286AV, E297KD
Machado (2012)CUPL1007CUPL1007HQ655384NoneNone  E6D, V8I, V21I, V35T, T39A, E40D, K49R, V60I, S68G, K122E, D123N, I135V, T139A, E169D, D177E, Q207E, K238KR, P243TD
 CUPL1048CUPL1048JN000020NoneNone  V8I, V35T, I37N, C38G, T39E, I47M, K49R, V60I, S68G, K122E, I135R, E169D, D177E, Q207AD
 CUPL1067CUPL1067JN000039NoneNone  V35T, T39A, E40D, K49R, V60I, S68G, E169D, D177E, Q197E, Q207N, R211K, P236T, V245K, D250E, A272Q, T286A, K311R, P313Q, I326V, I329V, R356K, M357V, T377Q, K390RD
Reynolds (2012)D0397D0397-0JN652146NoneNone  P4K, V8I, V35I, V60I, S68G, D121HY, K122E, I135T, D177DE, I178IM, T200I, Q207E, R211K, V245EKQ, D250DE, A272Q, V276I, L282C, L283I, T286A, I293VD
Ssemwanga (2012)RCC-TDR-483673RCC-TDR-483673JQ266082NoneNone  E6D, V35T, V60I, S68G, I135T, D177E, T200A, Q207ED
Kiptoo (2013)KAP066KAP066KC516924NoneNone  V35I, T39A, V60I, S68G, D121F, K122E, I135T, D177E, I178M, T200I, Q207E, R211K, P243PS, V245E, D250E, A272P, K277R, Q278H, L282C, L283I, T286A, I293VD
 KTL219KTL219KC517056NoneNone  V35T, T39A, E40D, V60I, S68G, D121H, I135T, S162C, D177E, T200I, Q207G, V245K, D250E, K277R, L282C, T286A, I293VD
 KAP049KAP049KC516898NoneNone  E6EK, E29EK, V35T, V60I, S68G, T69S, K122E, D123S, I135T, G196E, Q207N, R211K, V245Q, D250E, A272S, T286A, K287R, I293V, D320ED
Lee (2014)MBA1183MBA1183KJ906881NoneNone  M16L, V35T, V60I, S68G, D121H, K122E, S162SC, D177E, I178IM, T200IR, Q207E, R211K, V245VLM, D250E, A272V, K277KR, L282C, L283I, T286A, I293V, P294S, P345Q, F346Y, R356K, A360T, I375V, T377Q, S379C, K390R, A400TD
 MBA1478MBA1478KJ907156NoneNone  K32N, V35I, T39A, V60I, S68G, D121H, K122E, I135R, D177E, E194D, T200I, Q207E, R211K, V245T, D250E, A272P, K277R, L282C, I293V, G335D, P345Q, F346Y, R356K, M357V, A360T, E370G, T377Q, S379C, T386TI, K390R, A400TD
 MBA1075MBA1075KJ906775NoneNone  V35T, K49R, V60I, S68G, K122E, D123S, T165I, D177E, I178V, Q197E, T200I, Q207E, R211K, V245K, D250E, A272P, K277R, L282C, T286A, V292I, I293V, D324E, G335D, T338S, P345Q, F346Y, R356K, A360T, E370A, T377L, S379C, K390R, A400TD
 MBA1486MBA1486KJ907163NoneNone  P4PT, I5IV, V35T, V60I, S68G, K102KR, D121Y, K122E, R125K, D177E, I178M, T200I, Q207E, R211K, V245E, D250E, A272P, K277R, L282C, L283LI, T286A, A288AT, I293IV, I329IV, G335D, P345Q, F346Y, R356K, A360AT, T377Q, S379C, K390R, A400TD
 MBA1356MBA1356KJ907042NoneNone  V60I, S68G, K104R, D121H, K122E, E138EA, K173R, Q174HN, D177DE, T200I, Q207E, R211RK, V245E, D250E, A272P, G273A, K275Q, K277R, L282C, T286A, E291D, I293V, P294T, G335D, P345Q, F346Y, R356K, G359S, A360T, T377Q, S379C, K390R, A400TD
Hora (2015)DEURF11UG002DEURF11UG002KP109497NoneNone  V35I, K49R, V60I, S68G, D121Y, K122E, I135T, G141V, D177E, T200I, Q207R, R211K, P243S, V245K, E248D, D250E, A272P, K275Q, K277R, L282C, L283I, T286A, I293V, E297K, G335D, P345Q, F346Y, R356K, T377Q, S379C, K390R, A400T, E404D, E432D, A446S, K454R, Q480H, L491P, V493A, S519G, K530R, A534S, A554SD
Kouri (2015)AIDS-RP1AIDS-RP1KP688083NoneNone  V35T, V60I, S68G, K122E, D123S, I135V, E138G, E169D, R172K, D177E, I178L, Q207E, P243S, V245S, D250E, A272P, T286A, I329VD
Fokam (2016)CIRCB-17AHCIRCB-17AHKR229770NoneNone  P25PS, V35T, T39K, K49R, I50V, V60I, S68G, V106I, D123E, I135T, S162C, R172K, K173R, D177E, I178L, T200A, E204NS, Q207EG, R211K, F214L, V245T, D250E, A272P, K277R, T286A, I293V, E297X, E308EKD

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