<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype D
Gene RT
Mutation E44D
Rx RTI-naive
IncludeMixtures No
References 7
Patients 18
Isolates 18
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Richard (2004)RN_Pat12RNJLT12AAY556808NoneNone  V35T, E44D, V60I, S68G, D121H, K122E, A158S, Q174K, I178MD
Baker (2007)A1055MBA1055-261005EF186219NoneNone  V35T, E44D, V60I, D121H, K122E, I135T, I142V, Q174E, D177E, I178M, T200A, Q207A, R211S, V245Q, A272P, K277R, L282C, T286V, I293V, E297AD
Church (2007)766-141840J766EF612138NoneNone  K32R, V35T, T39A, E44D, K49KR, V60I, D121HY, K122E, I142T, D177E, I178M, Q207E, V245Q, A272P, K275KQ, K277KR, T286A, E291D, V292ID
Eshleman (2009)E13257W207-156981FJ389087NoneNone  E28G, V35T, E44D, K122E, D123N, I142V, Q174Q*, D177E, I178M, T200I, Q207D, R211K, F214L, V245K, I257L, L282C, R284K, T286A, I293V, P294SD
 C25290W308-102854FJ389144NoneNone  V35T, E44D, K49R, V60I, D121Y, K122E, S162C, D177E, T200I, Q207E, R211K, F214L, V245T, T253TN, A272P, K277R, L282C, E297KD
Hamers (2011)CP076300848CP076300848HQ995115NoneNone  K20R, V35T, E40D, E44D, K49R, V60I, V118I, K122E, I135M, E138A, E169D, R172K, D177E, I178L, I202V, Q207A, R211K, F214L, V245T, D250E, A272P, K277R, L282C, L283I, I293V, P294AD
 CP076300851CP076300851HQ995118NoneNone  K20R, V35T, E40D, E44D, K49R, V60I, V118I, K122E, I135M, E138A, E169D, R172K, D177E, I178L, I202V, Q207A, R211K, F214L, V245T, D250E, A272P, K277R, L282C, L283I, I293V, P294AD
 CP076300733CP076300733HQ995322NoneNone  V35T, T39A, E44D, V60I, K101R, D121Y, K122E, D123E, K166R, D177E, T200I, Q207E, R211K, V245K, D250E, I257L, A272P, K277R, L282C, I293V, E297QD
 CP076302933CP076302933HQ995489NoneNone  K32I, V35T, E36D, E44D, K49R, V60I, K102KN, T107TS, D121Y, K122E, I135T, Q161L, D177E, G196K, T200I, Q207R, R211K, V245K, A272P, K277R, L282C, L283I, I293V, K311RD
Ndembi (2011)AICPS233AICPS233HQ702655NoneNone  V35T, E44D, V60I, D121Y, K122E, D123E, I135T, I142V, K173S, Q174K, V179I, T200A, I202V, Q207A, R211SD
Lee (2014)MBA1189MBA1189KJ906887NoneNone  K20R, V35T, E40ED, K43KR, E44D, K49R, V60I, K122E, D123NS, D177E, I178M, V179VI, V189VI, Q197K, T200IM, Q207EG, R211K, P243PS, V245K, E248ED, D250E, A272P, K277KR, L282C, T286TA, I326IL, G335GD, P345Q, F346CDGY, R356K, M357MV, R358RK, A360T, T377Q, S379C, K390RD
 MBA1112MBA1112KJ906812NoneNone  K20R, K32KR, V35T, T39M, E44D, K49R, V60I, K104KR, D121DY, K122E, I142V, E169K, K173E, D177E, V179I, E194ED, G196E, T200A, Q207DE, R211K, D237DE, V245X, E248ED, A272G, K277R, T286A, E291ED, I293V, P294T, G335D, P345Q, F346Y, R356K, M357R, A360T, T377Q, K390RD
 MBA1147MBA1147KJ906845NoneNone  V35T, E44D, K49R, V60I, K122E, D123S, I135T, I142T, D177E, I178M, G196E, Q207A, R211S, V245Q, V276VI, K281R, L282C, L283I, T286A, I293V, P294T, E297KR, L310I, G335D, P345Q, F346Y, R356K, M357T, A360T, T377Q, S379C, K390RD
 AMU035AMU035KJ906655NoneNone  V21I, V35IM, E44D, K49KR, V60I, V106I, D121DY, K122E, D123DA, I142V, D177E, I178M, T200V, Q207EG, R211K, V245K, A272P, K277R, L282C, L283I, V292VI, I293V, V317VA, G335D, P345Q, F346Y, R356K, A360T, V365I, E370A, T377Q, S379C, K390RD
 MBA1055MBA1055KJ906756NoneNone  V35T, E44D, V60I, D121H, K122E, I135T, I142V, Q174E, D177E, I178M, T200A, E204EK, Q207A, R211S, V245Q, A272P, K277R, L282C, T286V, I293V, E297A, Q334QH, G335D, P345Q, F346Y, R356K, M357V, K366R, T377Q, S379C, K388R, K390R, A400SD
 MBA1512MBA1512KJ907188NoneNone  K20KR, V35T, E44D, K49R, V60I, K122E, E138A, T165I, E169D, I178L, V179I, T200I, I202V, Q207D, R211K, V245K, D250DE, A272P, K277R, L282C, K311R, G335D, P345Q, F346Y, R356K, I375IV, A376AT, T377Q, S379C, K390R, E399EDD
 MBA1457MBA1457KJ907136NoneNone  V35T, E44D, K49KR, E53ED, V60I, V118VI, K122KE, D177E, I178M, T200TI, Q207E, R211K, F214FL, V245K, D250DE, S251SI, A272P, K277KR, Q278QH, L282C, I293V, E297A, Q334L, P345Q, F346Y, R356K, M357MT, A360T, V365VI, T369A, Q373QH, K374KR, I375V, T377Q, S379C, K390RD
 MBA1128MBA1128KJ906826NoneNone  V35I, E44D, V60I, D121Y, K122E, D123E, I135T, D177E, I178IM, T200I, Q207EG, R211K, F214L, V245I, A272P, K277R, L282C, V292I, I293V, G335D, P345Q, F346Y, R356K, M357MR, A360T, K366KR, T377L, S379C, K390RD