<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype D
Gene RT
Mutation M41L
Rx RTI-naive
IncludeMixtures No
References 7
Patients 12
Isolates 12
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Gao (1998)94UG11494UG114U88824NoneNoneM41L V35I, T39S, V60I, D121H, K122E, I135T, D177E, I178M, V179I, T200I, Q207G, R211K, H221Y, V245H, D250E, A272P, K277R, L282C, T286A, E297A, V317A, G335D, P345Q, F346Y, R356K, A360T, T377Q, S379C, K390R, A400T, F416Y, L452I, H483N, L517V, A534S, A554N, V559ID
Church (2007)452-125040D452EF612032NoneNoneM41L V35I, T39A, E40ED, K49KR, V60I, T69A, D121Y, K122E, I142V, D177E, I178IM, T200TI, Q207G, R211K, V245K, D250E, A272P, K277R, L282C, L283I, I293V, K311KR, S322TD
 141315i141315iEF612187NoneNoneM41L E28K, V35T, E36D, T39A, K49R, V60I, D121Y, K122E, R125K, T139TA, D177E, I178M, T200TI, Q207E, R211RK, V245K, D250E, A272P, K277R, L282C, T286A, I293VD
Galluzzo (2007)M22620UG_M22620JQ220146NoneNoneM41L T39A, E40ED, K43R, K49R, V60I, V90VI, D121HY, K122E, R125RK, R172RK, K173KQ, D177DE, I178IM, T200TI, Q207G, R211K, V245KD
Eshleman (2009)E35130W307-156939FJ389072NoneNoneM41L K11H, V35E, K49R, V60I, D121Y, K122E, R125K, I135R, D177E, T200I, Q207G, R211K, V245I, D250E, A272P, L282C, T286A, I293VD
 K10192W107-156972FJ389082NoneNoneM41L I5V, E6ED, K32R, V35T, K49R, V60I, T69TI, D121Y, K122E, Q174R, D177E, I178V, T200I, Q207E, R211K, V245E, K249KQ, D250E, K281R, L282C, L283I, R284K, T286A, I293VD
Hamers (2011)CP076300708CP076300708HQ994921NoneNoneM41L V35T, K49KR, V60I, D121H, K122E, D177E, I178M, T200I, Q207R, R211K, V245K, D250E, A272T, L282C, T286A, I293V, E297DD
 CP076302071CP076302071HQ995031NoneNoneM41L V35T, K49R, V60I, K122E, D123G, E138G, A158S, K173E, Q174R, D177E, I178IM, T200TI, Q207DE, R211K, V245N, D250E, A272P, K277R, L282C, L283I, I293VD
 CP076300824CP076300824HQ995108NoneNoneM41L V35T, T39L, V60I, K122E, D123DN, I135T, I142V, D177E, I178M, Q207E, V245E, D250E, T286AD
 CP076302929CP076302929HQ995486NoneNoneM41L K20R, K22R, V35T, K49R, I50IV, V60I, K64KN, K101KR, K122E, I135IMV, D177E, T200I, Q207E, R211K, V245K, D250E, A272P, L282C, I293VD
Kasang (2011)1718417184HM572350NoneNoneM41L T7TP, K32R, V35T, T39K, V60I, D121CY, K122E, R125RK, I135T, I159IL, T165TI, D177E, T200I, Q207DG, R211K, I244V, V245K, E248D, D250E, S251D, L260LI, A272AP, L282C, L283I, R284RK, T286TA, I293V, P294PT, E297K, Q334HD
Kityo (2017)JFP005JFP005m0KT348000NoneNoneM41L V8I, G15R, V35T, T39M, E40D, K43R, K49R, V60I, D121Y, K122E, R125K, D177E, Q207E, R211K, V245I, D250E, A272S, K277RD