<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype D
Gene RT
Mutation E40D
Rx >= 1 NRTI
(but no NNRTI)
IncludeMixtures No
References 12
Patients 32
Isolates 33
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Weidle (2001)PW_UG468PW_UG468a AZT, 3TCNoneM184V I31L, V35T, E36K, T39A, E40D, K46Q, K49R, V60I, D121Y, K122E, E169D, D177E, T200A, Q207E, V245Q, D250E, S251I, A272P, K277R, T286A, E291D, E297A, I329V, G335D, R356Q, M357R, T377R, K390RD
Yahi (2001)NY_M40M40AY010497ABC, D4T, 3TCNoneM184V V35T, T39A, E40D, K49R, V60I, I63IL, D121Y, K122E, I142V, S162A, E169D, D177E, E203EK, Q207E, R211KD
Cuevas (2002)CU105CU105AF425486D4T, 3TCNone  V35T, T39A, E40D, V60I, W88C, V106I, K122E, D177E, T200A, Q207ED
 CU104CU104AF425485AZT, 3TCNone  V35T, E40D, K49R, V60I, T69S, I135T, E169D, D177E, Q197K, T200A, Q207ED
 CU95CU95AF425476AZT, 3TCNoneD67N, K70S, T215E V35T, T39A, E40D, K49R, V60I, F61C, K122E, I135T, S162C, E169D, D177E, T200A, Q207ED
 CU94CU94AF425475AZT, DDINone  V8I, V35T, T39A, E40D, K49R, V60I, K64R, S68G, F77S, T139A, E169D, D177E, Q207ED
 CU80CU80AF425461D4TNone  V35T, T39A, E40D, K49R, V60I, S68G, K122E, T139A, E169D, D177E, T200A, Q207ED
 CU73CU73AF425454AZTNone  V35T, E40D, K49R, V60I, K122E, I135T, S162C, E169D, D177E, Q207ED
 CU71CU71AF425452AZTNoneK70R, T215E V35T, T39A, E40D, K49R, V60I, K122E, S162C, E169D, D177E, Q207ED
 CU60CU60AF425441AZTNone  V35T, E40D, K49R, V60I, K122E, I135V, E169D, D177E, Q197H, Q207ED
 CU57CU57AF425438AZTNone  V21I, V35T, E40D, K49R, V60I, K122E, E169D, D177E, Q197K, T200I, Q207GD
 CU38CU38AF425419AZTNone  V35T, E40D, V60I, K122E, I135T, E169D, D177E, Q197K, F214LD
 CU31CU31AF425412AZT, 3TC, DDINone  V8I, V35T, T39A, E40D, K49R, V60I, S68G, D121H, K122E, I135V, T139A, E169D, D177E, Q207ED
 CU30CU30AF425411AZTNone  V21I, V35T, T39A, E40D, V60I, K122E, D123N, D177E, E194D, I195L, Q207ED
 CU23CU23AF425404AZTNone  V8I, V35T, T39A, E40D, K49R, V60I, S68G, K122E, I135V, T139A, E169D, D177E, Q207ED
 CU8CU8AF425389DDC, AZT, 3TCNone  E6K, E28R, K32E, V35T, E40D, K49R, V60I, K122E, E169D, Q207ED
Eshleman (2002)117886a117886aAF410206AZTNone  K22KN, L34LF, V35T, T39TI, E40D, K49KR, V60I, K122E, I135V, D177E, I178M, Q207E, V245K, D250E, A272P, K277R, T286A, I293VD
 139367i139367iAF410235AZTNone  V35T, E40D, K49R, V60I, K122E, D123DG, T139A, I142V, D177E, I178M, T200I, Q207G, R211K, V245Q, A272S, K277R, Q278H, K281R, L282C, T286A, I293VD
 144240v144240vAF410241AZTNone  V35VIM, E40D, K49KR, V60VI, K122E, D177E, I178IM, Q207EG, R211K, I244IV, V245K, D250DE, S251SC, A272P, K277R, L282C, L283I, T286A, I293VD
 150140g150140gAF410254AZTNone  V8I, V35T, E40D, K49R, V60I, K122E, D123S, I135R, D177E, I178M, T200I, Q207E, R211K, V245EK, D250E, A272P, K275R, K277R, Q278H, L282C, T286A, I293VD
Vergne (2003)VL01SN160HALD01SN160AJ583742D4T, DDINone  V35T, T39A, E40D, K49R, V60I, K122E, I135R, E169D, D177E, I178V, T200A, I202V, E204K, Q207E, R211K, F214L, V245T, D250E, A272P, K277R, Q278N, T286A, E297K, E308R, I329L, R356K, T369A, I375V, T377Q, S379C, K390R, A400T, T403I, E404D, N418D, K424ID
Montes (2004)MB_patHAN00_HAN704AJ577911DDI, AZT, DDC, D4T, 3TC, ABCNoneL74V, M184V V35T, T39L, E40D, D121Y, K122E, D177E, Q207E, R211KD
Richard (2004)RNJCR59RNJCR59AY5567763TC, D4TNone  V35T, E40D, K49R, V60I, S105A, D121C, K122E, I142V, D177E, I178M, T200ID
 RNJCR02RNJCR02AY556778AZT, 3TC, DDINoneM41L, D67N, K70R V35T, T39L, E40D, E44D, V60I, K104R, V118I, D121Y, K122E, D177E, I178M, G196E, T200AD
 RNJCR04RNJCR04AY556806AZT, 3TC, D4T, DDINoneM184V V35T, E40D, K49R, V60I, K122E, S162H, E169D, D177E, T200ID
 RNJCR07RNJCR07AY556805AZT, DDI, 3TC, D4TNoneD67N, K70R V35T, E40D, K49R, V60I, K122E, D123N, I135T, D177E, I178M, T200I, E203KD
 RNJCR28RNJCR28AY556809D4T, DDINone  K11T, V21I, V35T, T39R, E40D, V60I, D177E, I178MD
Delaunay (2005)DC_01818_2001w12DQ286508ABC, TDF, 3TCNoneM184IV179DV35T, E40D, K49R, E53D, V60I, V118I, K122Q, D123N, T165V, D177E, I178L, Q207E, F214LD
  18_2001w24DQ286509ABC, TDF, 3TCNoneM184V V35T, E40D, K49R, E53D, V60I, V118I, K122Q, D123N, T165V, D177E, I178L, E204N, Q207E, F214LD
Weber (2005)F86075F86075AY677601ABC, AZT, 3TCNoneD67N, K70R, M184V, T215Y V21VI, V35T, E40D, K49R, I50V, V60I, K101KQ, K122E, E169D, Q207E, V245K, D250E, A272PD
von Wyl (2007)1285248038EF449884NRTINoneM41L, D67N, T215Y V35T, E36D, E40D, K43R, K49R, V60I, K122E, D177E, T200I, Q207E, R211KD
Ndembi (2010)DT3527_05_P13527GQ409621ABC, AZT, 3TCNoneY115YF, M184V, T215F E6ED, V8VI, I31V, V35T, T39I, E40D, K49R, V60I, T69TS, K102R, D121DH, K122E, I135IT, A158AS, F160FS, E169D, D177E, I178M, T200A, Q207E, R211KD
Fokam (2011)CIRCB-9860CIRCB-9860JQ796162AZT, 3TCNone  P4PT, K11Q, P14A, V35T, E40D, V60I, V118I, K122P, D123N, T139S, S162C, D177E, I178L, V179I, E204K, Q207E, F214L, V245T, D250E, A272P, K277R, T286AD