<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype D
Gene RT
Mutation M184V
Rx >= 1 NRTI
(but no NNRTI)
IncludeMixtures No
References 14
Patients 40
Isolates 43
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Weidle (2001)PW_UG456PW_UG456aAY901266AZT, 3TCNoneM184V V35T, T39A, K43S, S48ST, V60I, K104KR, D121F, K122E, I142V, K166R, D177E, I178M, T200I, Q207G, R211K, V241X, V245Q, D250E, A272P, K277R, L282C, L283LI, T286X, I293V, I326IM, G335D, P345Q, F346Y, R356K, A360T, T377Q, S379C, T386TA, K390R, A400TD
 PW_UG465PW_UG465a AZT, 3TCNoneM184V, N348I V35T, K49R, V60I, D123E, D177E, I178M, G196E, Q207E, R211K, V245K, D250E, L282C, L283I, T286A, I293V, P294A, E297K, A304E, K323R, Q334E, G335D, P345Q, F346Y, R356K, M357S, R358K, A360T, E370A, I375V, T377Q, S379C, K390R, A400TD
  PW_UG465bAY901273AZT, 3TCNoneK70KR, M184V, N348I V35T, K49R, V60I, K64KR, K104KN, K122E, D123EK, I135IV, D177E, I178M, G196E, T200A, E203EA, Q207E, R211K, V245K, D250E, L282C, L283I, T286A, I293V, P294AT, E297R, A304E, D324DE, Q334E, G335D, P345Q, F346Y, R356K, M357S, R358RK, A360T, E370A, I375V, T377Q, S379C, K390R, A400TD
 PW_UG468PW_UG468a AZT, 3TCNoneM184V I31L, V35T, E36K, T39A, E40D, K46Q, K49R, V60I, D121Y, K122E, E169D, D177E, T200A, Q207E, V245Q, D250E, S251I, A272P, K277R, T286A, E291D, E297A, I329V, G335D, R356Q, M357R, T377R, K390RD
Yahi (2001)NY_M40M40AY010497ABC, D4T, 3TCNoneM184V V35T, T39A, E40D, K49R, V60I, I63IL, D121Y, K122E, I142V, S162A, E169D, D177E, E203EK, Q207E, R211KD
Gibb (2002)DMG8181_w56 ABC, 3TCNoneM184V, N348I V35T, E36A, T39D, V60I, K102Q, K122E, I135T, D177E, I178M, T200A, Q207E, R211K, V245M, D250E, A272P, T286A, E297K, Q334N, G335D, R356K, M357T, I375V, T377L, S379A, T386I, K390RD
 DMG9090_w51 AZT, 3TCNoneM184V, N348NI K22R, E28A, V35T, K49R, V60I, V106I, K122E, D123N, I135T, I142V, D177E, I178M, I195L, T200I, Q207G, R211K, V245K, A272P, L282C, T286A, I293V, E312EG, S322T, P345Q, F346Y, R356K, M357S, A360T, E370A, T377Q, T386I, K390R, E399DD
Montes (2004)MB_patHAN00_HAN704AJ577911DDI, AZT, DDC, D4T, 3TC, ABCNoneL74V, M184V V35T, T39L, E40D, D121Y, K122E, D177E, Q207E, R211KD
Richard (2004)RN_Pat2RNJLT01EAY556775AZT, 3TCNoneM184VK103NV35T, K49R, V60I, D121Y, K122E, D177E, I178M, V189I, T200MD
 RNJCR04RNJCR04AY556806AZT, 3TC, D4T, DDINoneM184V V35T, E40D, K49R, V60I, K122E, S162H, E169D, D177E, T200ID
 RNJCR24RNJCR24AY556791D4T, 3TC, DDINoneM41L, V75T, M184V V35T, K49R, V60I, D121C, K122E, D177E, I178M, Q197E, T200ED
 RNJCR29RNJCR29AY5567863TC, D4T, AZTNoneM184V P14A, K20R, V35T, K49R, V60I, D121Y, K122E, I135M, D177E, I178M, E194D, T200ID
Snoeck (2004)BE14aBE14a D4T, 3TCNoneM184V K20KR, V35VAIT, T39X, E40ED, V60VI, V118VI, K122E, D123DN, I135T, R172K, D177E, I178L, T200TA, E204EK, Q207QE, F214L, H221HY, V245T, D250E, A272P, T286A, I293V, P294T, K311R, V317VA, I329V, Q334ND
Delaunay (2005)DC_01818_2001w24DQ286509ABC, TDF, 3TCNoneM184V V35T, E40D, K49R, E53D, V60I, V118I, K122Q, D123N, T165V, D177E, I178L, E204N, Q207E, F214LD
Non-B Workgroup (2005)UK1392UK1392AY901334AZT, 3TCNoneD67N, K70R, M184V, K219Q V35T, K49R, V60I, D121Y, K122E, D123E, T139R, I159V, D177E, I178M, T200I, Q207E, R211KD
 IL105IL105bAY901747AZT, 3TC, D4T, DDINoneM41L, D67DN, M184V, T215Y V60I, K122E, D123E, G152GS, W153R, D177E, I178L, E194EK, G196E, R199*, Q207E, P225PT, V245TD
 TK3006TK3006 AZT, 3TCNoneM184V V35T, V60I, D121Y, K122E, I135T, D177E, I178IM, T200I, Q207E, R211K, F214L, V245E, D250E, A272P, K277R, L282C, L283I, R284RKD
 TK3008TK3008 AZT, 3TCNoneM184VP225HV35T, T39A, V60VI, Q91QH, D121CY, K122E, D123DE, I135IL, I142V, D177E, I178M, T200I, Q207E, R211K, F214X, V245E, E248D, D250DE, A272P, K277R, L282C, I293V, E297K, Q334QHD
 TK3011TK3011 AZT, 3TC, D4TNoneM184V L34X, V35ST, V60I, D121Y, K122E, D177E, I178M, T200I, Q207E, R211K, V245ED
 TK3021TK3021 AZT, 3TCNoneM184V V35T, K122E, I135V, D177E, I178M, E194D, Q207E, R211K, V245Q, P247A, A272P, V276T, I293V, P294PT, N306NKD
  TK3021a AZT, 3TCNoneM184V V35T, K122E, I135V, D177E, I178M, E194D, Q207E, R211K, V241VI, V245Q, P247A, A272P, V276T, K277KR, I293V, P294PS, H315XD
 TK3023TK3023 AZT, 3TCNoneM184V K13R, V35T, K49R, V60I, D121Y, K122E, K173A, Q174K, D177E, I178M, V179I, I195T, Q207E, V245T, D250E, A272P, K277R, L282C, I293V, H315Q, V317MD
 TK3037TK3037 AZT, 3TCNoneM184V K32R, V35T, K49R, K122E, D123E, A129AG, I135T, T165I, D177E, I178V, T200A, I202V, Q207E, R211K, F214L, V245E, D250E, A272P, K277R, T286AD
 TK4010TK4010 D4T, 3TC, AZTNoneM184V V35T, K49R, V60I, K122E, D123N, I135T, G152GV, E169D, Q174K, D177E, I178M, T200I, Q207E, R211K, I244V, V245Q, E248DN, A272P, K277R, L282C, P294ST, V317YD
 TK4014TK4014 AZT, 3TC, ABCNoneM41L, D67N, M184V, L210W, T215Y V35T, E44D, K49R, V60I, T69S, K122E, D123S, I135KR, S162X, D177E, I178M, V179VI, T200I, Q207E, R211RK, V245EK, D250E, A272P, K277R, L282C, L283I, A288AT, I293V, E297KD
 TK4016TK4016 AZT, 3TCNoneM184V, L210W, T215Y I31R, V35I, K49R, V60I, K122E, D123S, I135L, D177E, I178M, T200V, Q207E, R211K, V245E, D250E, A272P, L282C, L283I, T286A, I293V, D324E, Q334RD
 TK4018TK4018 AZT, 3TC, D4TNoneD67N, K70R, M184V, T215TS, K219Q V35I, I47L, V60I, T69TA, K103R, D121H, K122E, I135T, D177E, T200I, Q207E, R211K, V245K, D250DE, S251I, A272S, L282C, T286A, I293VD
 TK5013TK5013 AZT, 3TC, D4TNoneM41ML, D67N, T69D, K70KR, M184V, L210LW, K219KQA98AG, K103KTV35I, E44ED, I47IL, S48X, V60I, D121H, K122E, I135IT, D177E, T200I, Q207E, R211K, T215X, V245K, D250DE, S251SI, I257IL, A272PS, K281KR, L282C, T286A, I293VD
  TK5013a AZT, 3TC, D4TNoneM41L, D67N, T69D, M184V, L210W, T215YA98GV35I, E44D, S48E, V60I, V118VI, D121H, K122E, D177E, T200IL, I202IV, Q207E, R211K, V245K, A272P, K281KR, L282C, T286A, I293V, D324ED
Weber (2005)F86075F86075AY677601ABC, AZT, 3TCNoneD67N, K70R, M184V, T215Y V21VI, V35T, E40D, K49R, I50V, V60I, K101KQ, K122E, E169D, Q207E, V245K, D250E, A272PD
 01M612201M6122AY677602AZT, 3TCNoneK70R, M184V E6D, V35T, V60I, T69S, D121Y, K122E, K173A, Q174K, D177E, V179I, Q207A, R211S, F214L, V245T, P247T, D250E, A272P, K277R, L282C, T286A, I293V, E297AD
Laurent (2006)CK2-8402CM-84AM279448AZT, DDI, D4T, 3TCNoneK65R, F116Y, Q151M, M184V V35T, S48E, K49R, V60I, K64R, S68R, V118I, D123E, R172K, D177E, I178L, Q182H, Q207E, R211K, F214L, V245T, D250E, A272P, T286A, I293V, I329V, Y339W, A360T, A376S, K390R, T403MD
Koyalta (2009)8TCHAD-8FJ688175D4T, 3TCNoneD67N, K70R, M184V, K219E V60I, V106I, V118I, T139S, T165I, D177E, I178L, K201R, E204K, Q207E, R211K, F214LD
Ndembi (2010)13734D_P113734GQ409557ABC, AZT, 3TCNoneM184V E6D, V8I, K11IT, E28K, V35T, V60I, D121Y, K122E, D177E, T200I, Q207E, R211KD
 16496D_P116496GQ409586ABC, AZT, 3TC, D4TNoneL74V, Y115F, M184V, T215YK103NV35T, K49R, V60I, K122E, D177E, I178M, T200I, Q207E, R211KD
 16666D_P116666GQ409587ABC, AZT, 3TCNoneK65R, M184V E6G, I31L, V35T, E36D, K43R, V60I, K122E, I135T, I142M, S162H, F171L, I178M, T200M, L205S, Q207E, R211KD
 16735D_P116735GQ409589ABC, AZT, 3TC, D4TNoneK65R, K70R, V75I, F116Y, Q151M, M184V V35T, K43R, V60I, S68G, D121H, K122E, K173S, Q174K, D177E, I178M, T200M, Q207E, R211K, F214LD
 DT1335_05_P11335GQ409599ABC, AZT, 3TCNoneM184V I5V, V35T, K49R, V60I, F116S, D121Y, K122E, S162N, E169D, D177E, I178M, T200I, Q207E, R211KD
 DT2412_05_P12412GQ409606ABC, AZT, 3TCNoneM184V P4R, V8I, V35T, T39A, V60I, A62G, K122E, D177E, I178M, V179I, T200I, Q207E, R211KD
 DT3527_05_P13527GQ409621ABC, AZT, 3TCNoneY115YF, M184V, T215F E6ED, V8VI, I31V, V35T, T39I, E40D, K49R, V60I, T69TS, K102R, D121DH, K122E, I135IT, A158AS, F160FS, E169D, D177E, I178M, T200A, Q207E, R211KD
 DT3771_05_P13771GQ409624ABC, AZT, 3TCNoneD67N, M184V, T215Y V35T, V60I, K122E, I135IT, E169D, D177E, I178M, Q207E, R211KD
von Wyl (2010)47967344796734GQ848131AZT, 3TCNoneM41L, D67N, K70R, M184V, L210W, T215Y, K219E V35T, V60I, K101R, K122E, D123N, I135T, K166R, D177E, E203K, Q207E, R211K, V245K, D250E, A272P, Q334D, Y342F, M357A, T369A, S379G, K385R, K390R, K395R, A400TD
Inzaule (2016)1.02781.0278HM164116AZT, 3TCNoneM184V V35T, T39M, K49R, V60I, A98Q, D121Y, K122E, D123E, I135IT, K173S, Q174K, D177E, V179I, I195L, T200I, Q207E, R211K, V245I, D250E, L282C, L283I, R284K, I293V, D324ED