<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype CRF01_AE
Gene RT
Mutation L74V
Rx >= 1 NRTI
(but no NNRTI)
IncludeMixtures No
References 4
Patients 6
Isolates 6
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Gibb (2002)DMG1010_w56 ABC, 3TCNoneL74V, M184V E6D, K11T, V35T, T39K, K43KQ, D121H, K122E, I142IV, A158S, K173A, D177E, Q207A, R211RK, V245E, D250E, A272P, K275R, V276I, T286TA, E291D, V292I, I293V, P294T, E297K, E312D, G335D, R356K, M357K, G359S, T369A, A371V, I375V, A376T, K390R, K395RCRF01_AE
Hsu (2005)BAA150613BAA150613AY870154AZT, 3TC, D4T, ABCNoneM41ML, L74V, Y115F, M184V, T215Y E6D, K11T, V35T, T39K, K43E, V111VI, K122E, D123S, T139K, K173I, Q174K, D177E, Q207A, R211S, F214L, V245E, T286A, E291D, V292I, I293V, E312T, I326V, I329V, G335D, M357K, R358RG, G359S, D364DE, K366R, A371V, K390R, Q394QH, K395R, A400TCRF01_AE
Non-B Workgroup (2005)TH_184TH_184AY605592ABC, 3TC, DDINoneL74V, M184VV179DV35T, T39K, K43E, K103R, K122E, D123S, I135L, K173I, Q174K, D177E, T200E, Q207A, R211S, V245ECRF01_AE
 TH_220TH_220AY605625AZT, DDINoneL74V V35T, T39K, K43E, Q85H, K122E, D123S, K173I, Q174K, D177E, I178M, Q207A, R211SCRF01_AE
 TH_448TH_448AY901846D4T, DDINoneM41L, D67G, L74V, T215Y, K219NY181CV35T, T39K, K43E, E44A, S68G, V118I, K122E, D123S, K173I, Q174K, D177E, I178M, Q207A, K238R, V245ECRF01_AE
Khairunisa (2014)TD10TD10KM212836TDF, AZT, 3TCNoneM41L, L74V, M184V, L210W, T215YK101E, V108I, Y181C, G190A, M230LE6D, K11T, V35T, T39N, K43Q, T69N, V118I, K122E, D123S, I135V, E138Q, S162C, R172K, K173I, Q174K, D177E, I178M, Q207A, R211S, H221Y, K223R, V245ECRF01_AE