<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype CRF01_AE
Gene RT
Mutation S68G
Rx >= 1 NRTI
(but no NNRTI)
IncludeMixtures No
References 7
Patients 39
Isolates 40
 
Show mutation frequency as:
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Sutthent (2002)DP_THZ13DP_THZ13AF368835AZTNone  E6D, T7G, K11A, K22E, L26F, T27A, V35T, T39K, K43E, Y56C, S68G, K122E, D123S, I135T, K173I, Q174K, D177E, I178M, T200I, Q207A, R211S, K238R, V245E, T286A, E291D, V292I, I293V, R307K, E312A, I326V, I329V, G335D, M357K, G359S, K366R, A371V, K390R, K395R, A400T, E432D, D471E, Q480H, L491S, K512R, L517V, S519N, Q524E, A534S, A554SCRF01_AE
Ariyoshi (2003)JPN43JPN43BAY901410DDC, AZT, 3TC, D4TNoneD67G, K70R, M184V, T215F, K219E E6D, K11T, V35T, T39K, M41X, V60I, S68G, K122E, D123S, I135IT, K173T, Q174K, D177E, I178M, V179VI, Q207A, R211S, V245KCRF01_AE
 JPN28JPN28 AZT, 3TC, D4TNoneM41L, M184V, L210LW, T215F E6D, K11T, V35T, T39K, K43E, S68G, K122E, D123S, K173I, Q174K, D177E, I178IM, V179VI, Q207A, R211S, K238R, V245ECRF01_AE
 JPN3JPN3 DDC, AZTNone  K11T, V35T, T39K, K43E, V60I, S68G, K122E, D123S, I135T, K173I, Q174K, D177E, T200A, Q207A, R211S, K238R, V245ECRF01_AE
 JPN9JPN9A AZT, 3TC, DDINoneM184V E6D, K11T, V35T, T39K, K43E, S68G, K122E, D123NS, I135T, K173I, Q174K, D177E, I178M, V179VI, Q207A, R211S, K238R, V245ECRF01_AE
  JPN9BAY901422AZT, 3TC, DDINoneM184V V35T, T39K, K43E, S68G, K122E, D123NS, K173I, Q174K, D177E, I178M, Q207A, R211S, K238RCRF01_AE
 JPN21JPN21BAY901423DDC, 3TC, D4TNoneM184V E6N, I31IT, V35T, T39K, K43E, S68G, T69N, K122E, D123S, K173I, Q174K, D177E, I178M, Q207A, R211S, V245KCRF01_AE
 JPN24JPN24 AZTNone  E6D, K11T, I31T, V35T, T39KQ, K43E, S68G, K122E, D123S, K173I, Q174K, D177E, I178M, T200TA, I202L, Q207A, R211SCRF01_AE
Snoeck (2004)BE50BE50AY901305AZT, 3TCNoneL74LI, T215TN E6D, K11T, V35T, T39K, K43E, V60VI, S68G, V118VI, K122E, D123NS, I135T, R172RK, K173I, Q174K, D177E, T200I, Q207A, L210LS, R211S, K238R, V245E, K277R, T286A, E291D, V292I, I293V, E312TCRF01_AE
Hsu (2005)BAA148356BAA148356AY870142D4T, 3TCNoneM184V E6D, K11T, V35T, T39K, K43E, V60I, S68G, K122E, D123S, K173I, Q174K, D177E, I178M, T200A, Q207A, R211S, K238R, V245E, T286A, E291D, V292I, I293V, E312T, I326V, G335D, M357K, G359S, K366R, A371V, I375V, T377RCRF01_AE
 BAA148361BAA148361AY870146D4T, 3TC, DDINoneM184V, T215Y E6D, K11T, K20R, V35T, T39K, K43E, V60I, S68G, V106I, K122E, D123N, I135T, K173I, Q174K, D177E, I178L, T200A, Q207A, R211S, I244V, V245E, A272P, T286TA, E291D, V292I, I293V, P294Q, E312T, I326V, I329V, G335D, Y342F, M357K, G359S, K366R, T369A, A371V, K390R, K395RCRF01_AE
 BAA148362BAA148362AY870147AZT, 3TC, D4T, DDINoneM41L, L210W, T215SA98G, K101E, Y181CE6D, V35T, T39K, K43E, V60I, S68G, K122E, D123S, I135KR, K166R, K173I, Q174K, D177E, G196E, T200A, R206K, Q207A, R211S, V245E, A272P, T286A, I293V, E297K, E312A, I326V, I329V, G335D, P345Q, M357K, G359S, K366R, A371V, K390RCRF01_AE
 BAA157671BAA157671AY870176D4T, DDINoneK65R, K70HN, K219R E6D, T27S, V35T, T39KN, V60I, S68G, K122E, D123N, I135T, K173I, Q174K, D177E, I178M, Q207A, R211NS, K238R, V245E, E291D, V292I, I293V, K311R, E312T, I326V, I329V, G335D, R356K, M357K, G359S, K366KR, A371V, K390R, K395RCRF01_AE
Non-B Workgroup (2005)TH_217TH_217AY605620AZT, DDINoneM41L, D67E, T215F V35T, T39K, K43E, V60I, S68G, W88C, K122E, D123S, K173A, Q174K, D177E, Q207A, R211S, K238R, V245ECRF01_AE
 TH_234TH_234AY605640AZT, DDINoneA62V, V75I, F77L, Y115F, F116Y, Q151M, K219E V35T, T39E, K43E, S68G, K122E, D123S, F130I, N136T, T165D, R172K, K173I, Q174E, D177E, I178M, T200I, Q207N, R211S, K238R, V245ECRF01_AE
 TH_239TH_239AY605645AZT, DDINoneM41L, L210W, T215Y, K219Q K20R, V35I, T39K, K43E, V60I, S68G, K122E, D123S, I135T, K173I, Q174K, D177E, T200K, Q207A, R211S, K238R, V245ECRF01_AE
 TH_242TH_242AY605648AZT, DDINoneM41L, L210W, T215Y V35T, T39K, K43E, S68G, V118I, K122E, D123S, I135T, K173I, Q174K, D177E, I178M, T200I, E203D, Q207A, R211N, K220Q, V245E, E248DCRF01_AE
 TH_424TH_424AY901836D4T, DDINoneA62V, K65R, V75T, Q151M K20R, E28A, V35T, T39K, K43E, S68G, V106I, K122E, D123S, I135T, T165I, K173I, Q174K, D177E, I178M, I202V, Q207A, R211S, V245NCRF01_AE
 TH_426TH_426AY901837AZT, 3TCNoneM41L, M184V, L210W, T215Y V35T, T39K, K43E, S68G, K122E, D123S, I135T, K173T, Q174K, T200A, E203D, Q207A, K238R, V245ECRF01_AE
 TH_429TH_429AY901838AZT, DDINoneM41L, D67E, L210W, T215Y V35T, T39K, K43E, E44I, S68G, V118I, K122E, D123S, I135T, S162A, T165I, K173I, Q174K, D177E, Q207A, R211N, L234HCRF01_AE
 TH_448TH_448AY901846D4T, DDINoneM41L, D67G, L74V, T215Y, K219NY181CV35T, T39K, K43E, E44A, S68G, V118I, K122E, D123S, K173I, Q174K, D177E, I178M, Q207A, K238R, V245ECRF01_AE
 TH_473TH_473AY901852D4T, DDINoneM41L, D67E, L210W, T215Y V35T, T39R, K43E, S68G, V118I, K122E, D123N, K173A, Q174K, D177E, I178M, V179I, T200K, Q207A, R211N, V245DCRF01_AE
 TH_478TH_478 AZT, DDINone  V35T, T39K, K43E, N57H, V60I, S68G, K122E, D123S, T165I, K173I, Q174K, D177E, I178M, Q207A, R211S, M230T, K238R, V245ECRF01_AE
 TH_481TH_481AY901856AZT, DDINoneA62V, K65R, V75I, F77L, F116Y, Q151M, K219Q V35T, T39K, K43E, S68G, T69I, K122E, D123S, K173I, Q174K, D177E, I202V, Q207A, R211S, V245ECRF01_AE
 TH_496TH_496AY901860D4T, DDINoneV75T V35T, T39K, K43E, V60I, S68G, D121H, K122E, T139A, K173T, Q174K, D177E, I178M, Q207A, R211S, V245ECRF01_AE
 TH_528TH_528AY901870D4T, DDINoneK65R, Q151M A33V, V35T, T39K, K43E, N57H, S68G, K122E, D123S, K173I, Q174K, D177E, I178L, T200I, Q207A, R211S, F214L, K238R, V245ECRF01_AE
 TH_534TH_534AY901872D4T, DDINoneM41L, T215Y V35T, T39K, K43E, V60I, S68G, W88C, K122E, D123S, I135T, K173I, Q174K, D177E, D186E, V189I, Q207A, R211S, V245ECRF01_AE
 TH_550TH_550AY901874AZT, 3TCNoneM184V V35T, T39E, K49R, V60I, S68G, K122E, D123S, I132V, I135T, K166R, K173R, Q174K, D177E, I178M, Q207A, R211S, K238R, V245ECRF01_AE
 TH_556TH_556AY901878AZT, 3TCNoneK65R L34I, V35T, T39E, S68G, K102Q, K122E, D123N, S162N, K173I, Q174K, D177E, I178M, T200A, Q207A, R211S, V245ECRF01_AE
 TH_591TH_591AY901884DDC, AZTNoneM41L, D67E, V75M, L210W, T215YA98GK20R, V35T, T39K, K43E, V60I, S68G, V118I, K122E, D123N, K173A, Q174K, D177E, Q207A, R211N, K238R, V245ECRF01_AE
 TH_604TH_604 D4T, DDINoneK65R L34I, V35T, T39K, K43E, S68G, K122E, D123S, F124L, K173T, Q174K, D177E, I178M, Q207A, R211S, V245ECRF01_AE
 TH_619TH_619AY901896AZT, DDINoneM41L, T215F V35T, T39E, S68G, R78K, K122E, D123S, I135T, K173I, Q174K, D177E, I178M, S191Y, Q207A, R211S, V245ECRF01_AE
 TH_693TH_693AY901925AZT, DDINoneM41L, D67E, L210W, T215Y V35T, T39K, K43E, E44A, S68G, K102Q, K122E, D123N, K173I, Q174K, I178M, T200A, Q207A, R211N, K238R, V245ECRF01_AE
 TH_696TH_696 AZT, DDINoneM41L, L210W, T215Y V35T, T39K, K43E, E44A, V60I, S68G, V118I, K122E, D123S, I142V, K166R, K173I, Q174K, D177E, I178M, T200A, Q207A, R211NCRF01_AE
 TH_717TH_717AY901935AZT, DDINoneM41L, K65R, Q151M V35T, T39K, K43E, V60I, S68G, T69I, K122E, D123S, I142V, K166R, K173I, Q174K, D177E, I178M, T200I, Q207A, R211S, K238R, V245ECRF01_AE
 TH_785TH_785 AZT, DDINone  V35T, T39K, K43E, V60I, S68G, K122E, D123S, T165I, K173I, Q174K, D177E, I178M, T200A, Q207A, R211S, H221D, K238R, V245ECRF01_AE
 TH_408TH_408 AZT, D4T, DDINoneM41L, D67E, V75M, L210W, T215Y V35T, T39K, K43E, E44D, V60I, S68G, V118I, K122E, D123N, K166R, K173L, Q174K, D177E, I178M, Q207A, R211N, V245ECRF01_AE
Tee (2006)MYKL148203MYKL1482AY960889NRTI, D4T, DDINoneM184V, T215FA98GK20R, V35T, T39K, K43E, S68G, K122E, D123S, I135V, K166R, K173I, Q174K, D177E, Q207T, L210M, R211S, F214L, K238R, V245ECRF01_AE
 MYKL181404MYKL1814AY960904NRTI, AZT, 3TCNoneM41L, F116Y, Q151M, M184V E28G, E29G, L34M, V35T, T39K, E40G, K43E, V60I, S68G, K122E, D123S, K173I, Q174K, Q207A, R211S, F214L, K238R, I244V, V245ECRF01_AE
Riddler (2008)RG82111RG82111w55 TDF, 3TCNoneM184I E6D, K11T, V35T, T39E, V60I, S68G, V106I, K122E, D123S, K173R, Q174K, D177E, I178M, T200A, E203D, Q207A, R211S, K238R, W239R, V245E, D250E, V276I, T286A, E291D, V292I, I293V, K311Q, E312T, I326V, I329V, Q332QR, M357N, G359S, K366R, A371V, K388R, K390R, K395R, E399DCRF01_AE