<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype CRF01_AE
Gene RT
Mutation E40D
Rx RTI-naive
IncludeMixtures No
References 38
Patients 62
Isolates 63
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Lan (2003)NTHvr128NTHvr128AY238087NoneNone  E6D, K11T, K20R, V35I, T39E, E40D, K122E, D123NS, K173I, Q174K, D177E, I178M, Q207A, R211S, K238R, V245ECRF01_AE
 NTHvr43NTHvr43AY237999NoneNone  E6D, K11T, V35T, T39K, E40D, K49R, K122E, D123S, S162C, K173I, Q174K, D177E, I178M, Q207A, R211S, Q222QL, K238R, V245ECRF01_AE
Servais (2004)SJ_Pat5SJKLM030AJ413009NoneNone  I37X, E40D, K49KR, K122E, D123N, K173S, Q174K, D177E, V179I, Q207A, R211S, F214L, K238KICRF01_AE
 SJ_Pat11SJKLM050AJ413023NoneNone  I37X, E40D, K122E, D123N, K173S, Q174K, D177E, V179I, Q207A, R211S, F214L, V245QCRF01_AE
Ly (2005)NL_KHM_CA39KHM_CA39DQ013401NoneNone  E6D, V35T, T39N, E40D, K122E, D123S, S162C, K173T, Q174K, D177E, Q207S, R211S, K238R, V245KCRF01_AE
 NL_KHM_POP8KHM_POP8DQ013490NoneNone  E6D, K11T, V35T, T39E, E40D, K122KE, D123N, K173I, Q174K, D177E, I202V, Q207D, R211S, K238R, V245ECRF01_AE
 NL_KHM_SOS12KHM_SOS12DQ013503NoneNone  E6D, K11T, V35T, T39E, E40D, K122E, D123S, K173L, Q174K, D177E, I178M, Q207A, R211S, K238R, V245DCRF01_AE
Tee (2005)04MYKL188004_1880AY904708NoneNone  V35T, T39K, E40D, V106I, K122E, D123S, S162C, K173I, Q174K, D177E, V179I, Q207D, R211S, K238R, V245ECRF01_AE
Palacios (2008)1246412464 NoneNone  T39K, E40D, K43E, K122E, D123S, I135T, S162C, K173I, Q174K, D177E, V179VI, Q207A, R211S, K238R, V245DCRF01_AE
Sirivichayakul (2008)NBC-11NBC-11RTJQ364395NoneNone  V35T, E40D, K122E, D123S, K166R, K173I, Q174K, D177E, I178M, T200A, E203D, Q207A, R211S, K238R, V245ECRF01_AE
Wang (2008)CYM038CYM038EU921982NoneNone  E6D, K11T, V35T, T39K, E40D, K43E, K122E, D123S, S162C, K173I, Q174K, D177E, I178M, T200I, Q207A, R211S, K238R, V245E, A272PCRF01_AE
Ayouba (2009)FD0419FD0419RTGQ351997NoneNone  E40D, K64R, K122E, D123S, K173I, Q174K, D177E, Q207A, R211S, K238R, V245ECRF01_AE
 R17R17_RTGQ352183NoneNone  I2P, E6D, K11T, K20R, V35T, T39E, E40D, K122E, D123S, K173I, Q174K, D177E, I178M, T200I, Q207A, R211S, K238R, V245ECRF01_AE
Ishizaki (2009)A2_263A2_263FJ007055NoneNone  E6D, K11T, E28K, K32E, V35T, T39K, E40D, K122E, D123S, S162C, K173I, Q174K, D177E, I178M, Q207S, R211S, K238R, V245E, I257VCRF01_AE
 A434A434FJ007328NoneNone  E6D, K11T, V35T, T39K, E40D, K101Q, K102Q, K122E, D123S, T139A, S162C, K173I, Q174K, D177E, I178M, T200I, Q207S, R211S, D237N, V245ECRF01_AE
 A447A447FJ007331NoneNone  E6D, K11T, V35T, T39K, E40D, V106I, K122E, D123S, S162C, K173T, Q174K, D177E, T200I, Q207S, R211S, K238R, V245ECRF01_AE
Nouhin (2009)KC21KC21RTFJ531893NoneNone  E40D, V111I, K122E, D123N, K166R, K173IT, Q174K, N175H, I178L, V179I, Q207A, L210M, R211N, K238RCRF01_AE
Bonura (2010)1193_881193_88GU969548NoneNone  E6D, K11T, V35T, T39K, E40D, K43E, S68G, D121H, K122DE, D123GS, I135T, T139A, K173I, Q174K, D177E, I178M, Q207A, R211S, V245D, T286A, E291D, V292I, I293V, K311R, E312T, I326V, I329VCRF01_AE
Han (2010)LN143LN143FJ531448NoneNone  E6D, K11T, V35T, T39K, E40D, K122E, D123S, S162C, K173V, Q174K, D177E, I178M, T200I, Q207S, R211S, K238R, V245ECRF01_AE
Phan (2010)ND38ND38AB519464NoneNone  I5V, E6D, K11T, K20R, V35T, E40D, K102Q, K122E, D123S, S162C, K173I, Q174K, D177E, I178L, Q207S, R211SCRF01_AE
 O933O933AB519504NoneNone  E6D, K11T, V35T, T39K, E40D, K122E, D123S, S162C, K173I, Q174K, D177E, T200I, Q207S, R211SCRF01_AE
Dean (2011)IVVI7272IVVI7272JQ312414NoneNone  T39E, E40D, V111VG, D123N, K173IT, Q174K, D177E, Q207AD, R211RS, K238R, V245ECRF01_AE
Lazaro (2011)DT-M14DT-M14HQ542793NoneNone  K11R, V35T, T39N, E40D, K64KQ, K122E, D123S, S162C, K173I, Q174K, D177E, T200I, Q207A, R211S, K238RCRF01_AE
Ye (2011)BJ07261BJ07261JF906599NoneNone  E6D, K11T, V35T, T39K, E40D, K43E, K122E, D123S, S162C, K173I, Q174K, D177E, I178M, T200I, Q207A, R211S, K238R, V245E, A272P, E291D, V292I, I293VCRF01_AE
 BJ07286BJ07286JF906604NoneNone  E6D, K11T, V35T, T39K, E40D, K43E, K122E, D123S, S162C, K173I, Q174K, D177E, I178M, T200I, Q207A, R211S, K238R, V245E, A272P, E291D, V292I, I293VCRF01_AE
Karlsson (2012)SE_105SE_105JQ698740NoneNone  E6D, K11T, V35T, T39N, E40D, K122E, D123S, S162SDGN, K166KR, K173IR, Q174K, T200TI, Q207A, L210LF, R211S, V245K, K249QCRF01_AE
Thao (2012)HCMC_225HCMC_225JN786478NoneNone  V35T, T39N, E40D, V60I, Q91QH, K102Q, K103R, K122E, D123S, I135T, S162CY, K173R, Q174K, D177E, V179I, T200I, Q207A, R211S, F214L, D218DN, K238R, V245E, T286A, E291D, V292I, I293VCRF01_AE
Tran (2012)HPA262HPA262AB691026NoneNone  E6D, K11T, V35T, T39K, E40D, S162C, K173I, Q174K, D177E, V179I, T200A, Q207S, R211S, K238R, V245ECRF01_AE
Trinh (2012)VN-61VN-61HQ876646NoneNone  E6D, V35M, T39E, E40D, K122E, D123S, K173V, Q174K, D177E, T200I, Q207A, K238R, V245ECRF01_AE
Feng (2013)CYM105CYM105JX112798NoneNone V179DE6D, K11T, E28K, K32E, V35T, T39K, E40D, K64R, K122E, D123S, I135T, K173I, Q174K, D177E, T200I, Q207A, R211S, F214L, K238R, V245E, T286A, E291D, V292I, I293V, E312T, I326V, I329V, G335D, R356K, M357K, G359S, K366R, T369A, A371V, K395R, A400T, E432D, N447S, D460N, D471E, Q480H, H483Y, L491S, K512R, L517I, S519N, Q524E, I526V, A534S, A554SCRF01_AE
Han (2013)10LN32084210LN320842KC888307NoneNone  E6D, K11T, V35T, T39K, E40D, K122E, D123S, I135T, K173I, Q174K, D177E, T200I, Q207A, R211S, F214L, K238RCRF01_AE
Hawke (2013)1601010916010109KC237966NoneNone  E6ED, K11ST, V35T, T39A, E40D, L80LF, D121H, K122E, D123S, I135T, I142V, S162C, E169ED, K173S, Q174K, D177E, I178L, V179VI, G196E, T200A, Q207A, R211K, V245QCRF01_AE
 1810518318105183KC237990NoneNone  E6D, K11T, V35T, T39N, E40D, K122E, D123S, I135T, T165TI, R172K, K173IT, Q174K, D177DE, T200A, Q207A, R211S, V245KCRF01_AE
Kiertiburanakul (2013)R71TS248R71TS248KC921719NoneNone  V35T, T39A, E40D, I94L, K104Q, K122E, D123N, I142V, K173I, Q174K, D177E, E203K, Q207A, R211S, V245E, K249RCRF01_AE
 R41122R41122KC970972NoneNone  E6D, K11T, K20R, V35T, T39N, E40D, K122E, D123S, I135L, R172K, K173I, Q174K, D177G, I178M, G196E, T200A, Q207N, R211S, K238R, V245ECRF01_AE
 R41033R41033KC970923NoneNone  E6D, V35M, T39E, E40D, K122E, D123S, K173I, Q174K, D177E, I178V, T200I, Q207A, R211SCRF01_AE
 R74192R74192KC791411NoneNone  E6D, K11T, I31PS, V35T, T39N, E40D, V60I, K122E, D123S, K166R, K173I, Q174K, D177E, I178M, T200TA, Q207A, R211S, K238R, V245ECRF01_AE
Zheng (2013)VN_032VN_032JX123806NoneNone  I37X, T39K, E40D, V60I, T107S, K122E, D123S, S162C, K173I, Q174K, D177E, V179I, Q207N, R211S, K238R, V245ECRF01_AE
 VN_043VN_043JX123817NoneNone  I37X, T39K, E40D, K122E, D123S, S162C, K173I, Q174K, D177E, I178M, Q207R, R211S, K238R, V245ACRF01_AE
Chen (2014)YN107YN107HG421494NoneNone  E6D, V8I, V35T, T39N, E40D, K122E, D123NS, I135IT, I142IV, K166R, K173I, Q174K, D177E, Q197H, T200A, I202IV, Q207DEKN, R211S, V245E, A272P, L283I, A288G, E291D, V292VI, I293V, E297EA, E312T, I326V, G335D, P345PT, R356K, M357K, G359S, K366R, T369TA, A371V, K395R, A400T, E432DCRF01_AE
Schwem (2014)NIHA_77NIHA_77KX184191NoneNone  E6D, V35T, T39K, E40D, K43E, V60I, K122E, D123S, K173I, Q174K, D177E, T200V, E203D, Q207A, R211S, K238R, V245E, T286A, E291D, V292I, I293V, E312T, I326V, I329V, G335DCRF01_AE
 NIHA_13NIHA_13KX184121NoneNone  E6D, V35T, T39K, E40D, K43E, V60I, K122E, D123S, K173I, Q174K, D177E, I178M, T200V, Q207N, R211SCRF01_AE
Dauwe (2015)AE_48299AE_48299KT864081NoneNone  T39K, E40D, K43E, K122E, D123S, K173IV, Q174K, D177E, I178IM, Q207A, R211SCRF01_AE
Li (2015)SF101684SF101684KR187469NoneNone  E6D, V8I, K11T, V35T, T39K, E40D, K43A, K122E, D123S, I135T, K173I, Q174K, D177E, T200I, Q207A, R211S, F214L, K238R, V245ECRF01_AE
 SF13G289SF13G289KR188307NoneNone V179EE6D, K11T, V35T, T39K, E40D, K43E, K49R, V111I, K122E, D123S, K173R, Q174K, D177E, I178M, Q207A, R211S, K238R, V245ECRF01_AE
 SF13G173SF13G173KR188249NoneNone  P4ST, E6D, K11T, V35T, T39D, E40D, V118I, K122E, D123N, I135T, K166R, K173I, Q174K, D177E, Q207A, R211S, F214L, V245ECRF01_AE
Li (2015)NN13S0010NN13S0010KR823693NoneNone  E6D, K11T, V35T, T39K, E40D, K122E, D123S, F160FL, S162C, K173I, Q174K, D177E, G196GE, Q207KR, R211S, K238R, V245ECRF01_AE
 BJ14S0083BJ14S0083KR823103NoneNone  P4Q, E6D, V35T, T39A, E40D, K122E, D123S, I135T, K173M, Q174K, D177E, Q207A, R211S, F214L, K238R, V245K, E291D, I293VCRF01_AE
Yan (2015)SMS_VSR32SMS_VSR32KP418633NoneNone  E6D, K11T, V35T, T39A, E40D, V118I, D121H, K122E, D123S, I135T, T165I, K173M, Q174K, D177E, T200I, Q207A, R211S, F214L, K238R, V245E, K281RCRF01_AE
Yao (2015)JX05ZJ161JX05ZJ161KJ614055NoneNone  E6D, K11T, V35T, T39E, E40D, D121H, K122E, D123N, S162C, K173I, Q174K, D177E, I178L, Q207K, R211S, V245E, I293VCRF01_AE
Zhang (2015)NN13S0010NN13S0010KR106957NoneNone  E6D, K11T, V35T, T39K, E40D, K122E, D123S, F160FL, S162C, K173I, Q174K, D177E, G196GE, Q207KR, R211S, K219X, K238R, V245ECRF01_AE
 NN13S0034NN13S0034KR106970NoneNone  E6D, K11T, V35T, T39N, E40D, D121H, K122E, S162C, K173T, Q174K, D177E, I178M, Q207S, R211S, K219X, K238R, V245ECRF01_AE
Castley (2016)P094755826P094755826KT228554NoneNone  V35T, T39E, E40D, D121X, K122E, I135IV, S162C, K173L, Q174K, D177E, I178V, Q207A, R211SCRF01_AE
 P118295941P118295941KT228747NoneNone  V21VI, V35T, T39E, E40D, D86DE, K122E, D123S, S162A, K173X, Q174K, D177E, T200I, Q207A, R211SCRF01_AE
 P149487150DP149487150DKT229102NoneNone  K20KR, V35T, T39K, E40D, K101R, K122E, D123X, R172RK, K173I, Q174K, D177E, I178IM, T200TA, E204D, Q207N, R211SCRF01_AE
Chow (2016)MYNBB060MYNBB060KU535941NoneNone  E6D, K11T, V35T, T39E, E40D, V60I, S68G, K122E, D123N, I135R, K173M, Q174K, D177E, I178M, T200A, Q207A, R211S, V245E, A272P, K275R, E291D, V292I, I293VCRF01_AE
Saeng-Aroon (2016)5078150781LC114830NoneNone  E6D, V35T, T39A, E40D, K122E, D123S, I135IT, S162C, K173AITV, Q174K, D177E, I195L, Q207A, R211S, K238KR, V245E, S251HCRF01_AE
Van Tran (2016)VI-129VI-129LC100996NoneNone  E6D, K11T, E28K, K32KE, V35T, T39K, E40D, K122E, D123N, S162C, K173I, Q174K, D177E, I178LM, V179I, Q207S, R211S, V245E, K275Q, V276I, T286A, I293V, E297K, E312T, I326V, I329V, G335D, M357K, G359S, K366R, T369A, A371V, K390R, K395R, A400T, T403M, E432D, N447S, K465R, D471E, Q480H, L491S, K512R, L517V, S519N, Q524E, K530KR, A534S, A554TCRF01_AE
 VI-281VI-281LC101132NoneNone  E6D, V35I, T39N, E40D, V60I, S68G, K122E, D123S, I135T, T165I, K173R, Q174K, D177E, I178M, V179I, Q207A, R211S, V245E, A272P, T286A, E291D, V292I, I293V, E312T, I326V, I329V, G335D, E344D, M357K, G359S, K366R, A371V, K390R, A400T, T403M, E432D, D443DN, D471E, Q480H, H483Q, L491S, K512R, L517V, S519N, Q524E, K527N, E529D, A534S, Q547QK, A554Q, I556VCRF01_AE
 VI-155VI-155LC101021NoneNone  E6D, K11T, V35T, T39A, E40D, K122E, D123S, K173I, Q174K, D177E, I178M, Q197P, R211S, V245E, K249R, I293V, E312N, V317A, I326V, I329V, G335D, K350R, M357K, G359S, K366R, T369S, A371V, K390R, K395KR, A400T, T403M, E432D, N447S, E449D, D471E, Q480H, L491S, K512R, L517I, S519N, Q524E, A534S, A554SCRF01_AE
 VI-108VI-108LC100975NoneNone  E6D, K11T, K20R, V35T, T39AE, E40D, K122E, D123S, K173L, Q174K, D177E, V179I, T200I, Q207A, R211S, K238R, V245E, T286A, E291D, V292I, I293V, E312T, I326V, I329V, G335D, M357K, G359S, K366R, T369TA, A371V, K390KR, K395R, A400T, E432D, Q464K, D471E, Q480H, H483Y, L491S, K512R, L517V, S519N, Q524E, V531I, A534S, A554QCRF01_AE
 VI-410VI-410LC101253NoneNone  E6D, V35T, T39N, E40D, K122E, D123S, S162C, K173I, Q174K, D177E, Q207R, R211S, K238R, V245E, K281KR, T286A, V292VI, I293V, E312T, I326V, I329V, G335D, Y342YF, M357K, G359S, K366R, A371V, K390R, A400T, T403TM, E432D, N447S, L452I, D471E, Q480H, L491S, I505V, K512R, E514D, L517V, S519N, Q524E, A534S, A554SCRF01_AE
Zhao (2016)LS5559-LS5538LS5559-LS5538KT379634NoneNone  E6D, K11T, V35T, T39A, E40D, K43R, R78K, V118I, D121H, K122E, D123S, I135T, K173M, Q174K, D177E, T200I, Q207A, R211S, F214L, K238R, V245ECRF01_AE