<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype CRF01_AE
Gene RT
Mutation E40D
Rx RTI-naive
IncludeMixtures No
References 31
Patients 61
Isolates 61
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Lan (2003)NTHvr128NTHvr128AY238087NoneNone  E6D, K11T, K20R, V35I, T39E, E40D, K122E, D123NS, K173I, Q174K, D177E, I178M, Q207A, R211S, K238R, V245ECRF01_AE
 NTHvr43NTHvr43AY237999NoneNone  E6D, K11T, V35T, T39K, E40D, K49R, K122E, D123S, S162C, K173I, Q174K, D177E, I178M, Q207A, R211S, Q222QL, K238R, V245ECRF01_AE
Ly (2005)NL_KHM_CA39KHM_CA39DQ013401NoneNone  E6D, V35T, T39N, E40D, K122E, D123S, S162C, K173T, Q174K, D177E, Q207S, R211S, K238R, V245KCRF01_AE
 NL_KHM_POP8KHM_POP8DQ013490NoneNone  E6D, K11T, V35T, T39E, E40D, K122KE, D123N, K173I, Q174K, D177E, I202V, Q207D, R211S, K238R, V245ECRF01_AE
 NL_KHM_SOS12KHM_SOS12DQ013503NoneNone  E6D, K11T, V35T, T39E, E40D, K122E, D123S, K173L, Q174K, D177E, I178M, Q207A, R211S, K238R, V245DCRF01_AE
Tee (2005)04MYKL188004_1880AY904708NoneNone  V35T, T39K, E40D, V106I, K122E, D123S, S162C, K173I, Q174K, D177E, V179I, Q207D, R211S, K238R, V245ECRF01_AE
Holguin (2007)582659582659EF583193NoneNone  K11T, T27S, V35T, T39N, E40D, K49R, I50IV, D123N, K173AS, Q174K, D177E, I178IV, V179VI, T200A, Q207A, R211S, V245Q, K281R, T286A, E291D, V292T, I293V, P294A, E297R, A304ECRF01_AE
 605305605305EF583241NoneNone  E6D, V8I, K11T, V35T, T39L, E40D, K122E, D123S, I135T, I142V, S162H, K173AS, D177E, V179I, Q207E, R211K, V245Q, K281R, T286A, E291D, V292I, I293V, P294T, E297K, E312AD, V317VA, I326VCRF01_AE
Holguin (2008)SP28-292485SP28-292485EU255331NoneNone G190GST39M, E40D, K122E, D123S, A158S, K173S, Q174K, D177E, V179I, Q207A, R211SCRF01_AE
Palacios (2008)1246412464 NoneNone  T39K, E40D, K43E, K122E, D123S, I135T, S162C, K173I, Q174K, D177E, V179VI, Q207A, R211S, K238R, V245DCRF01_AE
Sirivichayakul (2008)NBC-9NBC-9RTJQ364393NoneNone  V35T, E40D, K122E, D123N, I142V, K173I, Q174K, D177E, Q207A, R211SCRF01_AE
 NBC-11NBC-11RTJQ364395NoneNone  V35T, E40D, K122E, D123S, K166R, K173I, Q174K, D177E, I178M, T200A, E203D, Q207A, R211S, K238R, V245ECRF01_AE
Wang (2008)CYM038CYM038EU921982NoneNone  E6D, K11T, V35T, T39K, E40D, K43E, K122E, D123S, S162C, K173I, Q174K, D177E, I178M, T200I, Q207A, R211S, K238R, V245E, A272PCRF01_AE
Ayouba (2009)FD0419FD0419RTGQ351997NoneNone  E40D, K64R, K122E, D123S, K173I, Q174K, D177E, Q207A, R211S, K238R, V245ECRF01_AE
 R17R17_RTGQ352183NoneNone  I2P, E6D, K11T, K20R, V35T, T39E, E40D, K122E, D123S, K173I, Q174K, D177E, I178M, T200I, Q207A, R211S, K238R, V245ECRF01_AE
Ishizaki (2009)A2_263A2_263FJ007055NoneNone  E6D, K11T, E28K, K32E, V35T, T39K, E40D, K122E, D123S, S162C, K173I, Q174K, D177E, I178M, Q207S, R211S, K238R, V245E, I257VCRF01_AE
 A434A434FJ007328NoneNone  E6D, K11T, V35T, T39K, E40D, K101Q, K102Q, K122E, D123S, T139A, S162C, K173I, Q174K, D177E, I178M, T200I, Q207S, R211S, D237N, V245ECRF01_AE
 A447A447FJ007331NoneNone  E6D, K11T, V35T, T39K, E40D, V106I, K122E, D123S, S162C, K173T, Q174K, D177E, T200I, Q207S, R211S, K238R, V245ECRF01_AE
Nouhin (2009)KC21KC21RTFJ531893NoneNone  E40D, V111I, K122E, D123N, K166R, K173IT, Q174K, N175H, I178L, V179I, Q207A, L210M, R211N, K238RCRF01_AE
Bonura (2010)1193_881193_88GU969548NoneNone  E6D, K11T, V35T, T39K, E40D, K43E, S68G, D121H, K122DE, D123GS, I135T, T139A, K173I, Q174K, D177E, I178M, Q207A, R211S, V245D, T286A, E291D, V292I, I293V, K311R, E312T, I326V, I329VCRF01_AE
Han (2010)LN143LN143FJ531448NoneNone  E6D, K11T, V35T, T39K, E40D, K122E, D123S, S162C, K173V, Q174K, D177E, I178M, T200I, Q207S, R211S, K238R, V245ECRF01_AE
Phan (2010)ND38ND38AB519464NoneNone  I5V, E6D, K11T, K20R, V35T, E40D, K102Q, K122E, D123S, S162C, K173I, Q174K, D177E, I178L, Q207S, R211SCRF01_AE
 O933O933AB519504NoneNone  E6D, K11T, V35T, T39K, E40D, K122E, D123S, S162C, K173I, Q174K, D177E, T200I, Q207S, R211SCRF01_AE
Aghokeng (2011)SK5013-PISK5013-PIHQ864375NoneNone  V35T, E40D, K49R, V60I, K122E, D123N, I135T, T165TI, K166R, Q174K, N175Y, D177E, I178M, G196E, Q207A, R211S, V245Q, E248D, T286A, E291D, I293V, L295M, K311KR, E312EDCRF01_AE
Dean (2011)IVVI7272IVVI7272JQ312414NoneNone  T39E, E40D, V111VG, D123N, K173IT, Q174K, D177E, Q207AD, R211RS, K238R, V245ECRF01_AE
Lazaro (2011)DT-M14DT-M14HQ542793NoneNone  K11R, V35T, T39N, E40D, K64KQ, K122E, D123S, S162C, K173I, Q174K, D177E, T200I, Q207A, R211S, K238RCRF01_AE
Ye (2011)BJ07261BJ07261JF906599NoneNone  E6D, K11T, V35T, T39K, E40D, K43E, K122E, D123S, S162C, K173I, Q174K, D177E, I178M, T200I, Q207A, R211S, K238R, V245E, A272P, E291D, V292I, I293VCRF01_AE
 BJ07286BJ07286JF906604NoneNone  E6D, K11T, V35T, T39K, E40D, K43E, K122E, D123S, S162C, K173I, Q174K, D177E, I178M, T200I, Q207A, R211S, K238R, V245E, A272P, E291D, V292I, I293VCRF01_AE
Dvali (2012)R110R110GQ268503NoneNone  K30Q, K32G, A33C, L34T, V35L, E36N, I37F, T39E, E40D, K122E, D123NS, A158S, K173L, Q174K, T200TA, Q207A, R211SCRF01_AE
 R042R042FJ456899NoneNone  V35L, E36N, I37F, T39K, E40D, K122E, D123S, I135T, K173L, Q174K, D177E, Q207A, R211S, F214FL, V245MCRF01_AE
 R100R100GQ268494NoneNone  V35L, E36N, I37F, T39KN, E40D, V118I, P119PT, K122E, D123N, A158S, K173S, Q174K, T200A, Q207A, R211S, F214L, V245MCRF01_AE
Karlsson (2012)SE_105SE_105JQ698740NoneNone  E6D, K11T, V35T, T39N, E40D, K122E, D123S, S162SDGN, K166KR, K173IR, Q174K, T200TI, Q207A, L210LF, R211S, V245K, K249QCRF01_AE
Nazziwa (2012)30366023036602JX498985NoneNone  K11T, K22R, V35T, T39K, E40D, K122E, D123G, I135T, K173L, Q174K, D177E, V179I, I202V, Q207A, R211SCRF01_AE
 10338021033802JX498988NoneNone  K11T, K20R, V21I, V35T, T39R, E40D, V60I, K122E, D123N, I135T, K173S, Q174K, D177E, V179I, T200A, I202V, Q207A, R211S, V245Q, E248D, D250E, A272V, K281R, T286A, E291D, V292I, I293V, E312N, I329V, G335DCRF01_AE
Ssemwanga (2012)3635HR3635HRJF800218NoneNone  V35T, E40D, K49R, V60I, D121H, K122E, I135V, I142V, K166Q, K173V, Q174K, V179I, Q207A, R211SCRF01_AE
Tran (2012)HPA262HPA262AB691026NoneNone  E6D, K11T, V35T, T39K, E40D, S162C, K173I, Q174K, D177E, V179I, T200A, Q207S, R211S, K238R, V245ECRF01_AE
Trinh (2012)VN-61VN-61HQ876646NoneNone  E6D, V35M, T39E, E40D, K122E, D123S, K173V, Q174K, D177E, T200I, Q207A, K238R, V245ECRF01_AE
Frentz (2013)EHR-49324EHR-49324JX300357NoneNone  K11A, V35T, E36D, T39N, E40D, V60I, K122E, D123S, I135T, K173L, Q174K, D177E, T200TI, Q207AT, R211S, V245IKCRF01_AE
 EHR-50112EHR-50112JX300370NoneNone  V21I, V35T, T39A, E40D, K49R, K122E, D123T, I135T, Q145H, Y146H, V148G, S156T, S162R, S163N, M164R, R172K, K173I, Q174K, I178K, Q207A, R211S, V245QCRF01_AE
 EHR-77855EHR-77855JX300882NoneNone  K11T, V35T, E36D, T39K, E40D, S68G, K122E, D123S, I135T, T165I, K173L, Q174K, D177E, V179I, Q207A, R211S, F214L, V245MCRF01_AE
 EHR-95312EHR-95312JX301114NoneNone  V8L, I31R, V35T, T39A, E40D, K49R, K122E, D123N, I135T, M164K, K166I, I167T, K173V, Q174K, D177E, Q207A, R211S, T216X, V245QCRF01_AE
Hawke (2013)1601010916010109KC237966NoneNone  E6ED, K11ST, V35T, T39A, E40D, L80LF, D121H, K122E, D123S, I135T, I142V, S162C, E169ED, K173S, Q174K, D177E, I178L, V179VI, G196E, T200A, Q207A, R211K, V245QCRF01_AE
 1810518318105183KC237990NoneNone  E6D, K11T, V35T, T39N, E40D, K122E, D123S, I135T, T165TI, R172K, K173IT, Q174K, D177DE, T200A, Q207A, R211S, V245KCRF01_AE
 2103286621032866KC238058NoneNone  K11T, K20R, V21I, V35T, T39E, E40D, T69S, K122E, D123N, K173S, D177E, V179I, T200A, I202V, Q207K, R211K, F214FL, V245Q, E248D, D250E, S251HCRF01_AE
Kemal (2013)87178717JQ364540NoneNone  K11A, K20R, V35T, E40D, K49R, K122E, D123N, I142V, S162H, K173I, Q174K, D177E, V179I, Q207A, R211S, E224D, P243T, V245Q, A272V, V276I, R284K, E291D, I293V, P294T, I326V, G335D, M357K, G359S, A371V, I375V, A376V, T377M, K395R, A400T, T403M, E404DCRF01_AE
Kiertiburanakul (2013)R71TS248R71TS248KC921719NoneNone  V35T, T39A, E40D, I94L, K104Q, K122E, D123N, I142V, K173I, Q174K, D177E, E203K, Q207A, R211S, V245E, K249RCRF01_AE
 R41122R41122KC970972NoneNone  E6D, K11T, K20R, V35T, T39N, E40D, K122E, D123S, I135L, R172K, K173I, Q174K, D177G, I178M, G196E, T200A, Q207N, R211S, K238R, V245ECRF01_AE
 R41033R41033KC970923NoneNone  E6D, V35M, T39E, E40D, K122E, D123S, K173I, Q174K, D177E, I178V, T200I, Q207A, R211SCRF01_AE
 R74192R74192KC791411NoneNone  E6D, K11T, I31PS, V35T, T39N, E40D, V60I, K122E, D123S, K166R, K173I, Q174K, D177E, I178M, T200TA, Q207A, R211S, K238R, V245ECRF01_AE
Kiptoo (2013)KTL074KTL074KC517013NoneNone  V21I, V35T, T39A, E40D, K49R, K122E, D123S, I135T, K173LS, D177E, T200A, Q207A, R211S, P243A, V245Q, A272P, K281R, L283I, E291ED, I293V, E297K, E312DCRF01_AE
 KAP031KAP031KC516884NoneNone  V35T, E40D, V60I, K122E, D123N, I135T, K173S, Q174K, D177E, V179I, T200A, Q207A, R211S, D250N, K281R, T286A, E291D, V292I, I293V, P294TCRF01_AE
 KAP062KAP062KC516923NoneNone  P14Q, V35T, E40D, V60I, D121HY, K122E, D123E, K173L, Q174K, D177E, I178IM, V179I, Q207A, R211S, V245M, E248D, D250E, A272P, T286A, E291D, V292I, I293V, P294T, E312NCRF01_AE
 KTL058KTL058KC517059NoneNone  K11A, V21I, V35T, T39K, E40D, V111VI, K122E, D123N, I135T, K173S, Q174QK, D177G, V179I, T200AE, I202V, Q207ADNT, R211NS, F214FL, V245Q, E248D, S251N, T286A, E291D, V292I, I293V, P294T, A304ECRF01_AE
 SNH063SNH063KC516948NoneNone  V35T, E40D, S48T, V60I, D121H, K122E, D123S, K166R, K173L, Q174EK, D177E, I178L, V179I, V189I, Q207A, D250E, T286A, E291D, V292I, I293V, P294T, E312DCRF01_AE
 SNH075SNH075KC516982NoneNone  V35T, E40D, K49R, V60I, G93GR, D123S, I135T, K173L, Q174K, D177E, V179I, T200E, Q207A, R211S, L228LF, H235HL, V245K, D250E, K275Q, T286A, E291D, V292I, I293V, P294T, E312DCRF01_AE
 KTL123KTL123KC517050NoneNone  V21I, V35T, T39A, E40D, K49R, K122E, D123S, I135T, K173LS, D177E, T200A, Q207A, R211S, P243A, V245Q, A272P, K281R, L283I, E291ED, I293V, E297K, E312DCRF01_AE
Rusine (2013)748H748HKC841761NoneNone  V35T, E40D, K49R, I50IV, V60I, K122E, D123S, T139L, S162D, K173S, Q174K, D177E, I178IM, V179I, T200A, Q207A, R211S, V245Q, E248N, A272P, Q278H, T286A, V292I, I293V, L310ICRF01_AE
 423H423HKC841681NoneNone  K11T, V35T, E40D, K49R, K122E, D123NS, I135T, T139V, K173S, Q174KR, D177E, V179I, T200TA, Q207A, R211NS, V245Q, T286A, E291D, I293V, P294PTCRF01_AE
Bartolo (2014)09AOHDP26709AOHDP267KF853694NoneNone Y188FK11S, L34F, V35T, E36V, I37S, E40D, D121H, K122E, K173A, T200A, Q207D, R211K, A272P, I293V, L295W, E297KCRF01_AE
 09AOHDP9809AOHDP98KF853751NoneNone  T27TS, V35T, T39KN, E40D, K122E, D123NS, I135IT, A158AS, S162SDGN, E169EG, K173AT, Q174DEKN, D177E, I195L, G196S, T200A, Q207A, R211S, V245K, D250E, L283I, T286A, E291D, I293V, P294T, L295MCRF01_AE
 09AOHDP16709AOHDP167KF853639NoneNone  V35T, E40D, K49R, E53D, V60I, K122E, D123S, I135T, I142V, Q174E, D177E, T200A, Q207N, R211K, P243A, V245Q, K281R, T286A, E291D, V292I, I293V, P294TCRF01_AE