<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype C
Gene RT
Mutation L74V
Rx >= 1 NRTI
(but no NNRTI)
IncludeMixtures No
References 6
Patients 13
Isolates 13
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Gibb (2002)DMG9595_w75 ABC, 3TCNoneL74V, Y115F, M184VV179VDV35T, T39E, S48T, V118I, K122E, D123N, E138A, I142V, K173I, Q174K, P176PS, T200E, Q207K, R211K, F214L, V245Q, E248D, K249Q, A272P, K275R, K277R, Q278H, E291D, V292I, I293V, P294E, D324E, I329L, Q334H, G335D, R356K, M357T, G359T, T369A, A376T, T377R, K390R, E396D, T397IC
Non-B Workgroup (2005)TK3009TK3009 AZT, 3TC, D4T, DDINoneL74V, M184V V35T, E36A, T39E, S48T, K122E, D123N, A158S, K173A, D177E, T200A, Q207E, Q222XC
Sen (2007)T076NPT76-PLEF186980AZT, D4T, 3TC, DDINoneD67G, K70R, L74V, K219Q V35T, E36A, T39D, S48T, K64N, D121Y, K122E, I135T, T165I, R172K, K173A, Q174R, D177E, I178L, T200A, E203K, Q207E, R211K, F214L, D218E, Q242QK, V245Q, A272P, K277R, L283I, I293V, G335D, R356K, G359AT, A360AT, V365VI, K390KR, A400T, E404DC
Pillay (2008)DR33DR33AY589890D4T, DDINoneL74V V35T, T39E, S48T, V60I, K122E, K173A, Q174K, D177E, I178L, T200A, K201KR, I202V, Q207E, R211K, V241I, V245Q, A272S, E291D, V292I, I293VC
Sylla (2008)B7173B7173_C2EF5256623TC, DDINoneD67N, L74V, M184I V35T, T39E, S48T, V60I, A98S, D121H, K122E, I135V, K173A, Q174K, P176T, I178L, T200A, Q207E, R211K, V245M, D250E, A272P, K277R, T286A, E291D, V292I, I293V, D324E, Q334H, G335D, R356K, G359T, T377M, K390R, A400T, E404D, V435VIC
Van Zyl (2013)833156KC423232ABC, 3TCNoneL74V, M184VV179ET27S, V35T, E36A, T39E, S48T, K64R, T69S, K122E, D123G, L149LF, S162C, K173A, T200A, E203EK, Q207E, R211K, V245K, E248DC
 14602908KC423889ABC, 3TCNoneL74V, Y115F, M184V V35T, E36A, T39D, S48T, V60I, K122E, E169A, K173E, D177G, T200A, Q207A, V245QC
 14532172KC423667ABC, 3TCNoneL74V, Y115F, M184V K20R, V35T, E36A, T39E, S48T, V60I, K122E, D123N, R125K, I135V, K173A, Q174K, D177E, T200A, Q207E, R211RK, V245QC
 14522906KC423888AZT, 3TCNoneL74V, Y115F, M184V K20R, V35T, E36A, T39E, S48T, V60I, K122E, D123N, I135V, K173A, Q174K, D177E, T200A, E203ED, Q207E, V245QC
 1144767KC424273D4T, 3TC, ABCNoneL74V, M184V V35K, E36A, T39E, S48T, V60I, K102R, S162C, K173A, Q174K, D177E, T200A, Q207E, R211K, D237DN, V245QC
 202459KC423723ABC, 3TCNoneK70Q, L74V, M184V V35T, E36A, T39D, S48T, K102Q, K122E, S162Y, K173A, Q174K, D177E, T200A, Q207N, R211K, V245Q, D250EC
 18163073KC423956ABC, 3TCNoneL74V, M184V V35K, E36A, T39E, S48T, V60I, K122E, I159V, K173A, T200A, Q207E, V245QC
 17321998KC423550ABC, 3TCNoneL74V, M184V, K219NY181CV35T, S48T, V60I, T165I, K173I, Q174K, T200A, Q207A, R211K, F214L, V245QC