<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype C
Gene RT
Mutation L74V
Rx >= 1 NRTI
(but no NNRTI)
IncludeMixtures No
References 10
Patients 27
Isolates 28
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Gibb (2002)DMG9595_w75 ABC, 3TCNoneL74V, Y115F, M184VV179VDV35T, T39E, S48T, V118I, K122E, D123N, E138A, I142V, K173I, Q174K, P176PS, T200E, Q207K, R211K, F214L, V245Q, E248D, K249Q, A272P, K275R, K277R, Q278H, E291D, V292I, I293V, P294E, D324E, I329L, Q334H, G335D, R356K, M357T, G359T, T369A, A376T, T377R, K390R, E396D, T397IC
Non-B Workgroup (2005)TK3009TK3009 AZT, 3TC, D4T, DDINoneL74V, M184V V35T, E36A, T39E, S48T, K122E, D123N, A158S, K173A, D177E, T200A, Q207E, Q222XC
Sen (2007)T076NPT76-PLEF186980AZT, D4T, 3TC, DDINoneD67G, K70R, L74V, K219Q V35T, E36A, T39D, S48T, K64N, D121Y, K122E, I135T, T165I, R172K, K173A, Q174R, D177E, I178L, T200A, E203K, Q207E, R211K, F214L, D218E, Q242QK, V245Q, A272P, K277R, L283I, I293V, G335D, R356K, G359AT, A360AT, V365VI, K390KR, A400T, E404DC
Pillay (2008)DR33DR33AY589890D4T, DDINoneL74V V35T, T39E, S48T, V60I, K122E, K173A, Q174K, D177E, I178L, T200A, K201KR, I202V, Q207E, R211K, V241I, V245Q, A272S, E291D, V292I, I293VC
Sylla (2008)B7173B7173_C2EF5256623TC, DDINoneD67N, L74V, M184I V35T, T39E, S48T, V60I, A98S, D121H, K122E, I135V, K173A, Q174K, P176T, I178L, T200A, Q207E, R211K, V245M, D250E, A272P, K277R, T286A, E291D, V292I, I293V, D324E, Q334H, G335D, R356K, G359T, T377M, K390R, A400T, E404D, V435VIC
Van Zyl (2013)O1144767KC424273D4T, 3TC, ABCNoneL74V, M184V V35K, E36A, T39E, S48T, V60I, K102R, S162C, K173A, Q174K, D177E, T200A, Q207E, R211K, D237DN, V245QC
 304307.ZA.GT155KC423232ABC, 3TCNoneL74V, M184VV179ET27S, V35T, E36A, T39E, S48T, K64R, T69S, K122E, D123G, L149LF, S162C, K173A, T200A, E203EK, Q207E, R211K, V245K, E248DC
 391412.ZA.GT2217KC423889ABC, 3TCNoneL74V, Y115F, M184V V35T, E36A, T39D, S48T, V60I, K122E, E169A, K173E, D177G, T200A, Q207A, V245QC
 17411.ZA.WC194KC423723ABC, 3TCNoneK70Q, L74V, M184V V35T, E36A, T39D, S48T, K102Q, K122E, S162Y, K173A, Q174K, D177E, T200A, Q207N, R211K, V245Q, D250EC
 53511.ZA.EC030KC423396ABC, AZT, 3TCNoneM41L, D67N, L74V, M184V, T215YA98G, K103N, K238TK20R, V35T, T39E, E44Y, S117A, K122E, D123S, I135L, E138A, S162CY, K173A, Q174K, Q207E, H208Y, R211K, W212R, V245K, D250EC
 537312.ZA.WC223KC423956ABC, 3TCNoneL74V, M184V V35K, E36A, T39E, S48T, V60I, K122E, I159V, K173A, T200A, Q207E, V245QC
 11112.ZA.EC176KC423817TDF, AZTNoneL74V, M184VK103N, V106M, F227FLE6K, K32R, V35T, T39E, E40D, K122E, D123E, S162C, D177E, T200A, Q207E, R211K, V245QC
 96611.ZA.WC171KC423550ABC, 3TCNoneL74V, M184V, K219NY181CV35T, S48T, V60I, T165I, K173I, Q174K, T200A, Q207A, R211K, F214L, V245QC
 389511.ZA.GT1894KC423667ABC, 3TCNoneL74V, Y115F, M184V K20R, V35T, E36A, T39E, S48T, V60I, K122E, D123N, R125K, I135V, K173A, Q174K, D177E, T200A, Q207E, R211RK, V245QC
  12.ZA.GT2215KC423888ABC, 3TC, AZTNoneL74V, Y115F, M184V K20R, V35T, E36A, T39E, S48T, V60I, K122E, D123N, I135V, K173A, Q174K, D177E, T200A, E203ED, Q207E, V245QC
Acharya (2014)DGP093DGP093KJ185263AZT, 3TCNoneM41L, L74V, Y115F, M184V, T215YK103N, V106MV35T, E36A, T39D, S48T, V60I, L109I, D121H, K122E, K173I, D177E, I178M, T200A, Q207E, V245Q, A272P, K277R, T286A, E291D, V292I, I293VC
Steegen (2014)12ZAKS35512ZAKS355KJ176634ABC, 3TC, D4TNoneD67N, L74V, M184V P4S, V35T, T39E, S48T, K122E, D123S, K173T, T200A, Q207D, R211K, V245Q, A272P, K275R, T286V, E291D, I293V, Q334E, G335D, R356K, M357R, R358K, G359S, A360T, E370D, A371V, T377M, K390R, E396D, A400T, E404DC
 12ZAKS25512ZAKS255KJ176534ABC, 3TCNoneL74V, M184IY181CV35T, T39K, S48T, V90I, K122E, S162C, K173A, D177E, T200A, Q207G, R211K, V245Q, A272P, Q278N, L279I, T286A, E291D, V292I, I293V, I329L, Q334N, G335D, R356K, M357R, G359T, T377M, K390R, A400TC
 11ZAKS18611ZAKS186KJ176467ABC, 3TCNoneL74V, Y115F, M184V E6D, V35T, E36A, T39E, S48T, K122E, D123S, E138A, T165I, K173T, Q174R, V179A, T200A, Q207E, R211K, F214L, T240TA, V245Q, E248D, A272P, K277KR, T286A, E291D, V292I, I293V, V317A, I329IV, G335DC
 12ZAKS28812ZAKS288KJ176567ABC, 3TCNoneL74V, Y115F, M184V E6D, V35T, E36A, T39E, S48T, K122E, D123S, E138A, T165I, K173T, Q174R, V179A, T200A, Q207E, R211K, F214L, T240TA, V245Q, E248D, A272P, K277KR, T286A, E291D, V292I, I293V, V317A, I329IV, G335D, Y342F, A355S, R356K, G359T, T369TA, A371V, A376T, T377TIM, T386A, K390R, E396D, A400T, E404DC
 12ZAKS29112ZAKS291KJ176570ABC, 3TCNoneL74V, M184V V35T, E36EA, T39E, E40ED, S48T, K122E, D123S, K173T, Q174K, V179I, T200A, Q207K, R211I, F214L, V245I, D250E, A272P, K275Q, K277R, Q278H, T286A, E291D, V292I, I293V, D324E, I329L, Q334N, G335D, R356K, M357R, G359T, V365I, K385R, K390R, A400T, T403S, E404DC
 11ZAKS14011ZAKS140KJ176422ABC, 3TC, D4TNoneL74V, M184V V35T, E36A, T39E, K43R, I135V, S162C, K173A, Q174K, D177E, T200A, Q207E, V245Q, D250DN, A272P, E291D, V292I, I293V, P313SC
Rossouw (2015)RP167RP167KT032058D4T, 3TC, ABCNoneL74V, M184V V35T, T39K, S48T, K122E, D123G, T165I, K173A, Q174R, D177E, T200A, R211K, F214L, V245Q, I257IV, A272P, K277R, T286A, E291D, V292I, I293V, L303IC
 RP152RP152KT032054ABC, 3TCNoneL74V, Y115F, M184V V35T, E36A, T39E, S48T, K122E, D123DG, K173A, Q174K, D177G, I178V, T200A, I202V, R211K, V245Q, D250E, A272P, I274V, Q278H, K281R, T286V, A288T, V292I, I293VC
Neogi (2016)77813.ZA.WC375KT593549AZT, 3TCNoneL74V, M184VK103N, V108IP4S, V35T, T39E, S48T, K122E, Q174R, D177E, I178M, G196V, T200A, Q207E, R211K, F214L, V245QC
 91413.ZA.WC348KT593534ABC, 3TCNoneM41L, D67N, K70R, L74V, K219QL100I, K103N, P225HP14S, V35T, E36A, T39E, S48T, T69TN, V90I, K173A, Q174K, D177E, T200A, Q207K, D218DE, V245KC
 95513.ZA.WC329KT593521ABC, 3TCNoneL74V, Y115F, M184VK101E, Y181CP9S, V35T, E36A, T39E, S48T, V60I, W88C, K122E, D123G, E138A, Q174E, T200A, Q207E, R211Q, F214L, H221Y, V245Q, E248DC
 408813.ZA.GT3082KT593348ABC, 3TCNoneL74V, M184V V35T, E36A, T39E, E40D, S48T, K122E, D123G, K173T, D177E, T200A, Q207K, V245QC