<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype C
Gene RT
Mutation K70R
Rx >= 1 NRTI
(but no NNRTI)
IncludeMixtures No
References 16
Patients 30
Isolates 31
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Hammer (1997)ACTG320_27402740 AZTNoneK70R V35T, T39E, S48T, V60VI, K122E, K173T, Q174QK, D177E, T200A, E203EK, Q207E, V245K, D250DE, A272P, K277R, T286AV, E291D, V292I, I293V, Q334H, G335D, R356K, G359NT, K366KR, T377M, K390R, A400T, E404D, V435A, A437I, L452M, Q464E, V466VI, S468P, D471E, T477A, H483QC
Venturi (1999)GV-22Vent22W24AF169085AZT, DDCNoneD67N, T69D, K70R V35T, T39E, S48T, D121H, K122E, D123S, A158S, S162T, K173T, D177E, T200A, Q207E, T215XC
Yahi (2001)NY_M3M3AY010476DDC, 3TCNoneD67N, K70R, M184V, K219Q K20KR, V35T, E36A, T39E, E40D, K43R, T69TN, K122E, D123S, A158S, K173A, Q174QR, D177DE, T200A, E203EK, Q207E, R211K, F214L, D218DE, L228HC
Cuevas (2002)CU81CU81AF425462AZT, DDINoneD67N, K70R V35T, T39E, K64R, T69N, A98S, D121H, K122E, D123S, K173A, D177E, I178L, I195M, Q197P, T200A, Q207EC
Kantor (2002)TCDD-23TCDD-23_1AY090850DDC, AZTNoneD67G, K70R, K219Q V35T, T39E, S48T, K64N, V90I, K122E, D123S, E138A, K173T, Q174K, T200A, E203K, Q207E, R211K, F214L, L228R, V245E, E248DC
Snoeck (2002)BE16aBE16aAF339010AZT, 3TCNoneD67N, K70R, M184V, K219Q V35T, T39N, S48SL, V60I, P119PL, D121DH, K122KE, D123DGNS, R125RG, I135R, N136NT, K173I, Q174K, D177E, T200A, Q207E, R211K, F214LC
Richard (2004)RNJCR09RNJCR09AY556758AZT, 3TC, D4T, DDINoneM41L, D67N, K70R, M184V P4T, V35T, T39E, K122E, D123S, A158S, K173A, D177E, T200AC
Snoeck (2004)BE60BE60AY901312AZT, 3TCNoneD67N, K70R, M184V V35T, T39E, S48T, K122E, D123N, I135IT, A158S, K173T, D177E, T200A, Q207EK, V245Q, A272P, K277R, T286A, E291D, V292I, I293VC
Non-B Workgroup (2005)UK1518UK1518AY901342AZT, 3TCNoneD67N, K70R, M184V V35T, E36A, T39E, S48T, K122E, D123S, I135T, S162NY, K173T, D177E, T200X, Q207KC
 IL128IL128eAY901356AZT, 3TC, DDINoneM41L, D67N, K70R, T215YY181ST39E, E44D, V118VI, K122E, D123S, I135T, W153L, S163C, K173T, D177E, T200A, Q207E, K223KR, Y232*, W239RC
 UK1998UK1998AY901375ABC, AZT, 3TCNoneD67N, K70R, M184V V35T, T39K, S48T, K122E, D123E, K173T, Q174K, D177E, T200E, Q207D, R211KC
 UK2034UK2034AY901387AZT, DDINoneD67N, K70R, K219KQ V35T, E36A, T39E, S48T, K103KR, K122E, D123S, I135V, I159V, T165I, K173T, D177E, T200A, E203K, E204EK, Q207E, R211K, D218DE, W229WGC
 UK2109UK2109AY901401ABC, AZT, 3TCNoneD67N, K70R, M184V K20R, V35T, T39E, K43KR, S48T, K104R, K122E, D123N, I135T, E138A, K173I, Q174K, I195IM, T200A, E203EK, Q207E, L210LM, R211K, F214LC
 SA84_DR29SA84_DR29AY901717AZT, 3TCNoneD67N, K70R, K219QK103N, G190AV35T, E36A, T39E, S48T, V60I, K122E, D123G, V148VG, K173A, D177E, T200A, E203Q, Q207E, H221Y, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, V317AC
 IL293IL293AY901766AZT, 3TC, DDINoneK70R, M184V T39E, K64R, T69N, A98S, K122E, D123S, A158S, K173A, D177E, T200A, Q207EG, H208HY, R211K, H235HY, V245QC
Weber (2005)M83284M83284AY677581D4T, DDI, ABC, AZT, 3TCNoneD67N, K70R, M184V, T215FY, K219W S48T, V60I, D121H, K122E, D123S, I142V, S162X, K173T, Q174R, D177E, I178L, T200A, Q207E, R211K, A272P, K277R, T286A, E291D, V292I, I293V, V317DNC
 M66914M66914AY677584AZT, DDI, 3TC, D4TNoneD67N, K70R, M184V, T215V, K219Q V21I, V35T, T39E, K43R, T69TS, K122E, D123S, I135V, K173T, Q174K, D177E, Q207E, V245Q, K249Q, A272P, T286A, E291D, V292I, I293VC
Sen (2007)T076NPT76-PLEF186980AZT, D4T, 3TC, DDINoneD67G, K70R, L74V, K219Q V35T, E36A, T39D, S48T, K64N, D121Y, K122E, I135T, T165I, R172K, K173A, Q174R, D177E, I178L, T200A, E203K, Q207E, R211K, F214L, D218E, Q242QK, V245Q, A272P, K277R, L283I, I293V, G335D, R356K, G359AT, A360AT, V365VI, K390KR, A400T, E404DC
Pillay (2008)DR15DR15AY589875AZT, DDINoneD67N, K70R, K219E K20R, V35T, T39K, S48T, V60I, V118I, K122E, D123N, A158S, S162G, K173T, Q174A, T200A, E203EK, Q207E, R211K, F214L, V245Q, D250E, S251D, A272P, K277R, Q278E, E291D, V292I, I293V, E297KC
 DR37DR37AY589894AZT, D4T, 3TC, DDI, ABCNoneD67N, K70R, L74IV, M184V, K219KE V35M, T39D, S48T, V60VI, D123DN, K173A, Q174K, T200A, E203K, Q207E, R211K, V245Q, K249KQ, D250E, A272P, K277R, E291D, V292I, I293VC
 DR7603ZA.DR76AY589922D4T, DDINoneD67N, K70R, K219Q V35T, E36A, T39E, K64KN, K122E, D123DG, K173A, Q174K, D177E, I178L, T200A, Q207KN, L210LF, R211KM, V245Q, A272P, K277R, Q278H, T286A, I293VC
Deshpande (2009)Pat24814artFJ530693AZT, 3TCNoneD67N, K70R, M184V, T215F, K219EA98AGV35T, T39E, S48T, V60I, T69N, V118I, D121H, K122E, I135T, K173AT, D177E, I178M, T200A, E204K, Q207E, F214L, E224D, V245QC
 Pat21316RTFJ530728AZT, 3TCNoneM41L, D67N, K70R, M184V, T215F, K219QA98G, K101EQ, G190AK20R, E28EK, V35T, T39D, E44D, S48T, V60I, T69N, D121H, K122E, F124FV, I135T, K173A, Q174R, I178M, T200A, Q207E, R211RK, V245Q, L246WC
 Pat18369RTFJ530758AZT, 3TC, D4TNoneD67N, K70R, M184V, K219QV106M, G190AT27S, V35T, E36A, T39D, S48T, V60I, T69S, D121Y, K122E, I135T, E138Q, S162A, K166R, K173A, D177E, V179I, G196K, Q197R, R199RG, T200A, Q207G, R211K, F214LC
 Pat044327FJ530897AZT, 3TCNoneM41ML, D67N, K70R, V75M, M184AV, T215F, K219EG190AL12I, V35T, T39N, V60I, T69TN, D121HY, K122E, I135M, S162SN, K173A, D177E, V179I, E203EV, Q207E, L228H, V245QC
 Pat043329FJ530898AZT, 3TCNoneM41L, D67N, K70R, V75M, M184V, T215F, K219EG190AV35T, T39N, V60I, D121H, K122E, I135M, K173T, D177E, V179I, Q207E, L228H, V245QC
 Pat042336FJ530899AZT, 3TCNoneD67N, K70R, M184V, T215FI, K219EK103KN, Y181YC, G190A, K238KTT27TS, V35T, T39D, E40ED, V60I, L109I, D121H, K122E, I135T, K166R, K173T, Q174R, D177E, T200A, I202V, Q207E, R211K, L228H, V245QC
 Pat004447RTFJ530937AZT, 3TCNoneM41L, D67N, T69D, K70R, M184V, T215Y V35T, T39D, V60I, D121Y, K122E, I135V, K173A, D177E, T200A, Q207E, R211K, V245QC
Kassaye (2009)TCDD-23TC23_2003FJ445712DDC, AZTNoneD67G, T69T_T, K70R, K219Q V35T, T39E, S48T, V60I, K64N, K103KR, V118I, K122E, D123S, E138A, T139A, K173T, Q174K, T200A, I202V, E203K, Q207E, R211K, F214L, D218E, L228HR, V245E, E248DC
Ndembi (2010)DT2295_05_P12295GQ409604ABC, AZT, 3TCNoneK70R, M184V V35T, S48T, V60I, E79EQ, K122E, D123G, K173A, Q174K, D177E, Q197P, T200A, E203K, Q207E, R211KC
Van Zyl (2013)751548KC424133AZT, DDINoneD67N, K70R, T215TI, K219KE V35T, T39E, S48T, K122E, D123S, K166R, K173A, Q174K, D177E, I178M, T200A, Q207E, R211RK, V245QC