<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype C
Gene RT
Mutation T69S
Rx RTI-naive
IncludeMixtures No
References 21
Patients 91
Isolates 91
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Ciccozzi (2005)MC_AY611651C68AY611651NoneNone  V35T, T39K, S48T, T69S, V118I, K122E, D123S, E138A, T200A, Q207K, R211A, F214L, V245Q, E248N, D250E, A272P, K281R, T286A, E291D, V292I, I293V, I326VC
 MC_AY611665C20AY611665NoneNone  V35T, T39K, S48T, T69S, V118I, K122E, D123S, E138A, T200A, Q207K, R211A, F214L, V245Q, E248N, D250E, A272P, K281R, T286A, E291D, V292I, I293V, I326VC
Rousseau (2006)Pt102PS001MB1DQ275648NoneNone  E6K, V35T, E36A, T39E, S48T, V60I, T69S, K122E, D123G, K173T, Q174K, D177E, T200A, Q207G, R211K, V245K, A272P, T286V, E291D, V292I, I293V, V317A, Q334H, G335D, R356K, M357R, G359A, I375V, T377M, K390R, A400T, E404D, I434M, V435A, A437V, L452I, S468T, L469I, D471E, H483Q, L491P, V496I, S519N, Q524E, K530R, A534S, A554SC
Vidal (2007)B108502BU.B1085AM260268NoneNone  V35T, E36A, T39E, E40D, S48T, V60I, T69S, K122E, K173A, D177E, T200A, Q207A, V245M, D250E, A272P, K277R, E291D, V292I, I293V, P294Q, G335E, R356K, G359T, T369V, Q373H, I375V, A376S, T377Q, S379C, K390R, E399D, A400I, E404DC
Lall (2008)G16G16-AFMC8EU158871NoneNone A98GV8I, V35T, E36A, T39D, S48T, V60I, T69S, D121HY, K122E, I135L, I142IT, K166R, K173AT, T200A, Q207K, R211K, V245Q, A272P, K277R, T286A, K287E, E291D, V292I, P294T, Q334H, G335D, R356K, G359T, T377M, K390RC
Matthews (2008)PS001PS001FJ199584NoneNone  E6K, V35T, E36A, T39E, S48T, V60I, T69S, K122E, D123G, K173T, Q174K, D177E, T200A, Q207G, R211K, V245K, A272P, T286V, E291D, V292I, I293V, V317A, Q334H, G335D, R356K, M357R, G359A, I375V, T377M, K390R, A400T, E404D, I434M, V435A, A437V, L452I, S468T, L469I, D471E, H483Q, L491P, V496I, S519N, Q524E, K530R, A534S, A554SC
 PS088PS088FJ199663NoneNone  V21I, V35T, E36A, T39E, S48T, V60I, T69S, K122E, D123G, I135V, K173A, Q174K, D177E, T200A, Q207E, R211K, V245Q, A272P, Q278K, T286A, E291D, V292I, I293V, Q334D, G335D, R356K, G359T, T377L, K390R, E396D, A400M, E404D, V435A, A437V, L452M, Y457D, S468P, T470S, D471E, H483Q, L491S, E492K, S519N, K527R, K528R, K530R, A534S, A554NC
Nyombi (2008)TBK076TBK076EU251763NoneNone  V35T, E36A, T39E, S48T, T69S, K122E, A158S, K166R, K173T, D177E, T200A, Q207E, V245Q, A272Q, K277R, T286A, E291D, V292I, I293V, G335D, F346H, R356K, G359T, T377LC
Bonura (2010)1166_411166_41GU969533NoneNone  T27S, V35T, E36AV, T39E, S48T, P59PS, T69S, V106VI, K122KE, D123DG, S162C, K173A, Q174QK, D177E, G196K, T200A, Q207E, R211K, V245Q, E248D, A272P, L279M, T286TA, E291D, V292VI, I293V, K311KR, D324EC
Gonzalez (2010)LUK6LUK6GQ433854NoneNone  P4S, V35T, E36A, T39E, E40D, S48T, T69S, K122E, D123S, K173T, D177E, T200A, E204K, Q207E, V245Q, D250E, A272P, K277R, T286A, E291D, V292I, I293VC
Ferreira (2011)BRMT2528BRMT2528HQ638705NoneNone V108IV35T, E36A, T39D, T69S, K102Q, D123S, K173T, D177E, I178L, T200A, Q207A, R211KC
Hamers (2011)300153CP076300153HM119728NoneNone  V10VI, K20R, V35T, T39AE, S48T, V60I, T69S, V118I, K122E, D123DEG, K173A, Q174R, D177E, G196E, T200A, Q207E, R211K, F214FL, V245Q, A272P, V292I, I293V, E308KC
 300430CP076300430HM119854NoneNone  V35T, E36A, T39E, S48T, T69S, D121Y, K122E, D123G, S162C, K173A, D177E, I178IV, T200A, E204Q, Q207E, P243S, V245Q, A272P, T286TA, E291D, V292I, I293V, I309FC
 300432CP076300432HM119856NoneNone  V35T, E36A, T39E, S48T, T69S, K122E, A158AS, K173A, Q174HR, T200A, I202V, Q207E, R211RK, V245Q, E248D, D250E, S251D, A272P, K277S, T286A, E291D, V292I, I293V, E297G, N306ST, L325FC
 300444CP076300444HM119866NoneNone  V35T, T39E, S48T, T69S, K122E, D123S, K173T, D177E, T200A, E204K, Q207D, R211RK, V245Q, D250E, A272P, K277R, T286A, E291D, V292I, I293V, L325V, I329G, Q330RC
 CP076300366CP076300366HQ994380NoneNone  I5V, K20R, V35T, E36D, T39R, S48T, K49R, V60I, T69S, L100F, K122E, D123S, I135L, E138A, T139A, K173A, T200A, I202V, Q207E, R211K, F214L, V245Q, A272P, K277R, E291D, V292I, I293V, P294T, E297A, V314AC
 CP076300922CP076300922HQ994541NoneNone  V35T, T39E, S48T, T69S, E89K, L100X, K122E, D123G, E169D, K173A, Q174K, D177E, T200A, Q207E, R211K, V245Q, A272P, K277R, E291D, I293VC
 CP076301053CP076301053HQ994584NoneNone  V10VI, K20R, V35T, T39AE, S48T, V60I, T69S, V118I, K122E, D123DEG, K173A, Q174R, D177E, G196E, T200A, Q207E, R211K, F214FL, V245Q, A272P, V292I, I293V, E308KC
 CP076300938CP076300938HQ994715NoneNoneM41L V35K, T39E, V60I, T69S, K122E, D123S, K173A, D177E, T200A, Q207E, R211K, V245Q, A272P, K275Q, Q278NC
 CP076302703CP076302703HQ994841NoneNone  V35T, T39D, S48T, V60I, T69S, W88C, K122E, S162A, K166R, K173A, D177E, I178IL, T200A, Q207E, R211K, V245Q, A272Q, K277R, T286A, E291D, V292I, I293VC
Nwobegahay (2011)08MB38ZA08MB38ZAGU188775NoneNoneD67E, K70V V35T, E36A, T39E, S48T, I63L, S68P, T69S, W71Q, K122E, D123N, I142V, S162C, K173A, Q174K, D177E, I178L, T200A, Q207E, R211KC
Parboosing (2011)Pat024HRS144HQ844602NoneNone  V35T, E36A, T39E, S48T, V60I, T69S, K122E, D123S, I135V, I142IM, E169D, K173A, Q174K, D177E, I178M, T200A, Q207D, R211K, V245Q, A272P, K277R, T286A, E291D, V292I, I293VC
Tshabalala (2011)SCR385SCR385HQ874346NoneNone  V8I, V35T, E36A, T39E, S48T, T69S, K122E, D123N, K173T, Q174K, T200A, I202V, Q207E, R211K, F214LC
Zeng (2011)K45K45JF505511NoneNone  V35T, E36A, T39D, S48T, E53D, V60I, T69S, I135V, S162C, T200A, Q207E, R211KC
 K26K26JF505535NoneNoneA62V V35T, E36A, T39D, S48T, E53D, V60I, T69S, S162C, Q207E, R211KC
 K82K82JF505610NoneNone  V35T, E36A, T39D, S48T, E53D, V60I, T69S, I135V, S162C, D192N, T200A, Q207E, R211KC
Chen (2012)YN09DH0167YN09DH0167JQ658623NoneNone  V35T, E36A, T39E, S48T, E53D, V60I, T69S, I135L, S162C, Q207E, R211K, V245Q, A272P, K277KR, T286A, V292I, I293VC
 YN10DH0059YN10DH0059JQ658682NoneNone  V35KT, E36A, T39D, S48AEKT, E53D, V60I, T69S, I135V, S162SC, T200A, Q207E, R211K, V245Q, A272P, V276I, K277R, T286A, V292I, I293VC
 YN10DH0077YN10DH0077JQ658698NoneNone  I5IV, K20R, V35T, E36A, T39D, S48T, E53D, V60I, T69S, S162C, Q207E, R211K, V245Q, A272P, K277R, T286TA, V292I, I293VC
 YN10DH0081YN10DH0081JQ658702NoneNone K101KNV35T, E36A, T39D, S48T, K49R, E53D, V60I, T69S, K102KE, E138A, S162C, I178IM, V179VI, Q207E, R211K, V245Q, A272P, K277R, E291D, V292I, I293VC
Zeng (2012)CN0037CN0037JQ028286NoneNone  V35T, T39N, S48T, E53D, V60I, T69S, I135V, S162C, T200A, Q207E, R211K, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, V317A, D324E, G335D, R356K, G359T, T377M, K390R, A400T, E404D, E432D, V435A, L452I, R461K, Q464K, H483Y, L484I, L491S, S519N, Q524E, K530R, A534S, A554NC
 CN0340CN0340JQ028287NoneNone  V35T, T39N, S48T, E53D, V60I, T69S, K122E, I135V, S162C, Q207E, R211K, V245E, A272P, K275R, K277R, E291D, V292I, I293V, V317A, D324E, G335D, R356K, G359A, T377M, T386V, A400T, E404D, E432D, V435A, Q464K, H483Y, L484I, L491S, S519N, A534S, A554NC
 CN0700CN0700JQ028289NoneNone  V35T, E36A, T39D, S48T, E53D, V60I, T69S, E89G, I135V, S162C, Q207E, R211K, V245Q, A272S, K275R, K277R, T286A, E291D, V292I, I293V, V317A, D324E, G335D, R356K, G359A, T377M, T386I, K390R, A400T, E404D, K431Q, E432D, V435A, A437V, L452I, R461K, Q464K, H483Y, L484I, L491S, S519N, K530R, A534S, P537S, A554NC
 CN0891CN0891JQ028290NoneNone  V35T, E36A, T39D, S48T, E53D, V60I, T69S, L80P, I135V, S162C, Q207E, R211K, V245E, A272P, K277R, T286A, E291D, V292I, I293V, V317A, D324E, G335D, Q340R, E344V, R356K, G359T, I375M, T377M, K390R, A400T, E404D, E432D, V435A, A437V, L452I, Q464K, V466I, T477S, H483Y, L484I, L491S, Q509K, S519N, A534S, A554NC
 CN0896CN0896JQ028291NoneNone  V35I, T39N, S48T, E53D, V60I, T69S, I135V, T200I, Q207E, P243L, V245K, S251V, A272P, K277R, T286A, I293V, D324E, Q334H, G335D, R356K, G359T, T377Q, T386I, A400T, E404D, E432D, V435A, A437V, L452I, Q464K, T473A, H483Y, L484I, L491S, S519N, K527S, K530R, A534S, A554NC
 CN0897CN0897JQ028292NoneNone  V35T, E36A, T39D, S48T, E53D, V60I, K64R, T69S, I135R, Q207E, R211K, V245Q, A272P, K277R, T286V, E291D, I293V, H315Q, V317A, D324E, G335D, R356K, G359T, T377M, T386I, K390R, A400T, E404D, E432D, V435A, A437V, L452I, Q464K, H483Y, L484T, L491S, S519N, K530R, A534S, A554NC
 CN0899CN0899JQ028293NoneNone  V35T, T39N, S48T, E53D, V60I, T69S, I135V, S162C, Q207E, R211K, V245E, A272P, K277R, T286A, V292I, I293V, K311R, V317A, D324E, G335D, R356K, G359A, T377M, T386I, A400T, E404D, E432D, V435A, A437V, L452I, Q464K, H483Y, L484I, L491S, S519N, K530R, A534S, A554NC
 CN0922CN0922JQ028294NoneNone  V35T, E36A, T39D, S48T, E53D, V60I, T69S, G112A, K166R, Q207E, R211K, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, A304E, D324E, G335D, R356K, G359T, A376S, T377M, T386I, K390R, A400T, E404D, E432D, V435A, L452I, Q464K, H483Y, L484I, Q487K, L491S, S519N, K530R, A534S, A554NC
 CN0985CN0985JQ028295NoneNone  K32R, V35T, T39N, S48T, E53D, V60I, T69S, I135V, S162C, S191P, Q197R, Q207E, V245E, S251G, A272P, K277R, T286A, E291D, I293V, D324E, G335D, R356K, G359T, T377M, T386I, E396D, A400T, E404D, E432D, L452I, D460N, Q464K, L469I, H483Y, L484I, Q487K, L491S, S519N, K527R, K530R, A534S, A554SC
 CN0988CN0988JQ028296NoneNone  V35T, E36A, T39D, S48T, E53D, V60I, T69S, I135V, S162C, Q207E, R211K, V245Q, A272P, K277R, T286A, V292I, I293V, V317R, D324E, G335D, R356K, G359T, T377I, K390R, A400T, E404D, E432D, V435A, A437V, L452V, Q464K, V466I, H483Y, L484I, L491S, S519N, K527R, K530R, A534S, A554TC
 CN0993CN0993JQ028297NoneNone  V35T, T39N, S48T, E53D, V60I, T69S, I135V, S162C, Q207E, R211K, V245Q, E248T, A272P, V292I, I293V, A304E, V317A, D324E, G335D, R356K, G359T, T377M, T386I, A400T, E404D, E432D, V435A, A437V, L452I, Q464K, H483Y, L484I, L491S, L517I, S519N, K530R, A534S, A554NC
 CN0994CN0994JQ028298NoneNone  V35T, E36A, T39D, S48T, E53D, V60I, T69S, I135V, S162C, Q207E, R211K, V245Q, A272P, K277R, T286V, V292I, I293V, D324E, G335D, R356K, G359T, T377M, K390R, A400T, E404D, E432D, V435A, A437V, L452I, Q464K, V466I, H483Y, L484I, L491S, S519N, K527R, K530R, A534S, A554NC
 CN0996CN0996JQ028299NoneNone  V8I, V35T, E36A, T39D, S48T, E53D, V60I, T69S, F87S, I135V, S162C, Q207E, R211K, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, V317A, D324E, G335D, R356K, G359T, T377M, T386I, K390R, A400T, E404D, E432D, V435A, A437V, Q464K, H483Y, L484I, L491S, S519N, E529D, K530R, A534S, A554NC
 CN1000CN1000JQ028300NoneNone  V35T, E36A, T39D, S48T, E53D, V60I, T69S, I135V, S162C, D177N, Q207E, R211K, V245E, A272P, K277R, T286A, V292I, I293V, V317T, D324E, G335D, R356K, G359T, T377M, K390R, A400T, E404D, E432D, V435A, A437V, L452I, Q464K, H483Y, L484I, L491S, S519N, K530R, A534S, A554SC
 CN1004CN1004JQ028301NoneNone  V35T, E36A, T39D, S48T, V60I, T69S, I135V, S162C, I167V, Q207E, R211K, V245Q, K249R, A272P, K277R, T286A, E291D, V292I, I293V, V317A, D324E, G335D, R356K, G359T, T377L, T386I, K390R, A400T, E404D, E432D, V435A, A437V, L452M, Q464K, H483Y, L484I, L491S, S519N, K530R, Y532C, A534S, A554NC
 CN1216CN1216JQ028302NoneNone  V35T, E36A, T39D, S48T, E53D, V60I, T69S, D123E, I135V, S162C, Q207E, R211K, V245Q, A272P, K277R, E291D, V292I, I293V, K311T, V317A, D324E, G335D, R356K, G359T, T377M, T386I, K390R, A400T, E404D, E432D, V435A, L452I, Q464K, V466I, V467I, H483Y, L484I, L491S, S519N, K530R, A534S, V548I, A554NC
 CN1238CN1238JQ028303NoneNone  K20R, V35T, E36A, T39E, S48T, E53D, V60I, T69S, K102R, I135V, S162C, D177E, Q207E, R211K, V245Q, E248T, K249Q, A272P, K277R, T286A, E291D, V292I, I293V, V317A, D324E, G335D, R356K, G359A, T377M, T386I, A400T, E404D, E432D, V435A, A437V, L452I, V467I, H483Y, L484I, L491S, S519N, K530R, A534S, A554N, V559IC
 CN1241CN1241JQ028304NoneNone  K20R, V35T, T39N, S48T, E53D, V60I, T69S, I135V, Q207E, R211K, V245K, K249Q, A272P, K277R, V292I, I293V, P313S, V317A, D324E, G335D, R356K, G359T, T377M, T386I, A400T, E404D, Y405W, E432D, V435A, A437V, L452I, Q464K, H483Y, L484I, L491S, S519N, A534S, A554NC
 CN1251CN1251JQ028305NoneNone  K20R, V35K, E36A, T39D, S48T, E53D, V60I, T69S, S162C, Q207E, R211K, V245H, A272P, K277R, T286V, E291D, I293V, V314I, D324E, G335D, R356K, G359S, A376S, T377M, T386I, A400T, E404D, E432D, V435A, L452I, Q464K, V466I, H483C, L484I, L491S, S519N, K527R, K530R, A534S, A554NC
 CN1254CN1254JQ028306NoneNone  V35T, E36A, T39D, S48T, E53D, V60I, T69S, I135V, S162C, Q207E, R211K, V245Q, A272P, K277R, T286V, V292I, I293V, V317A, D324E, G335D, R356K, G359T, A376T, T377M, T386I, K390R, E399D, A400T, E404D, E432D, V435A, A437V, L452I, Q464K, V466I, H483C, L484I, L491S, S519N, K527R, K530R, A534S, A554NC
 CN1317CN1317JQ028307NoneNone  V35T, E36A, T39D, S48T, E53D, V60I, T69S, I135V, E138A, S162C, V179I, Q207E, R211K, V245Q, A272P, K277R, T286A, K287R, E291D, V292I, I293IV, V317A, D324E, G335D, R356K, G359A, T377M, K390R, A400T, E404D, E432D, V435A, L452I, Q464K, H483Y, L484I, L491S, S519N, Q520L, K530R, A534S, A554NC
 CN1322CN1322JQ028308NoneNoneT215A K20R, V35T, E36A, T39E, K43R, S48T, E53D, V60I, T69S, K102Q, I135V, S162C, Q207E, R211K, V245Q, A272P, K277R, E291D, V292I, I293V, V317A, D324E, G335D, K350R, R356K, G359A, T377M, T386I, K390R, A400T, E404D, Y405W, E432D, V435A, A437V, L452I, Q464K, H483Y, L484I, L491S, S519N, K530R, A534S, A554NC
 CN0693CN0693JQ028384NoneNone  K20R, V35T, E36A, T39E, S48T, E53D, V60I, T69S, I135V, S162C, Q207E, R211K, V245H, A272P, K277R, E291D, V292I, I293V, A304E, D324E, G335D, R356K, G359T, T377M, A400T, E404D, E432D, V435A, A437V, L452I, Q464K, V466I, H483Y, L484I, L491S, S519N, I522M, K530R, A534S, A554SC
 CN0923CN0923JQ028385NoneNone  V35T, E36A, T39D, S48T, E53D, V60I, T69S, I135T, S162C, Q207E, R211K, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, A304E, V317A, D324E, G335D, R356K, G359A, A376S, T377M, T386I, K390R, A400T, E404D, E432D, V435A, A437V, L452I, Q464K, H483Y, L484I, Q487R, L491S, S519N, E529D, K530R, A534S, A554N, K558RC
 CN0924CN0924JQ028386NoneNone  V35T, E36A, T39D, S48T, E53D, V60I, T69S, I135V, S162C, Q207E, R211K, V245Q, A272P, K277R, E291D, V292I, I293V, K311Q, V317A, D324E, G335D, R356K, G359A, T377M, K390R, I393T, A400T, E404D, E432D, V435A, A437V, L452I, Q464K, H483Y, L484I, L491S, S519N, K530R, A534S, A554NC
 CN1292CN1292JQ028387NoneNone  K20R, V35T, T39N, S48E, E53D, V60I, T69S, K102Q, I135V, S162C, V189A, Q207E, R211K, V245Q, A272P, K277R, T286V, E291D, V292I, I293V, D324E, G335D, R356K, G359T, K366R, A371V, T377M, T386I, K390R, A400T, E404D, E432D, V435A, A437V, L452I, Q464K, V466I, H483Y, L484I, L491S, S519N, K527S, K530R, A534S, A554SC
 CN1366CN1366JQ028388NoneNone  V35T, E36A, T39D, S48T, E53D, V60I, T69S, I135V, S162C, Q207E, R211K, V245E, A272P, K277R, V292I, I293V, V317A, D324E, G335D, P345Q, R356K, G359T, T377M, T386I, A400T, E404D, E432D, V435A, A437V, L452I, Q464K, V466I, H483Y, L484I, L491S, S519N, K530R, A534S, Q547E, A554K, K558RC
 CN1244CN1244JQ028391NoneNone  V35T, E36A, T39D, S48T, E53D, V60I, T69S, I135V, S162C, Q207E, R211K, V245Q, A272P, K277R, E291D, V292I, I293V, V317A, D324E, G335D, P345Q, R356K, G359T, T377M, T386V, K390R, A400T, E404D, E432D, V435A, A437V, L452I, Q464K, V466I, H483Y, L484I, L491S, Q507H, S519N, I526V, K527R, K530R, A534S, V548I, A554SC
 CN0035CN0035JQ028395NoneNone  I5V, K20R, V35T, E36A, T39D, S48T, K49R, E53D, V60I, T69S, I135V, S162C, Q207E, R211K, V245Q, A272P, K277R, V292I, I293V, D324E, G335D, R356K, G359T, A376S, T377M, K390R, A400T, E404D, A408T, E432D, V435A, A437V, L452I, Q464K, H483Y, L484I, L491S, K512R, S519N, K527R, K530R, A534S, A554NC
 CN0325CN0325JQ028412NoneNone  V35T, E36A, T39D, S48T, E53D, V60I, T69S, I135V, I142V, S162C, T200A, Q207E, R211K, V245Q, A272P, K277R, T286A, I293V, D324E, G335D, R356K, G359T, T377M, K390R, A400T, E404D, E432D, V435A, A437V, L452I, R461K, Q464K, H483Y, L484I, L491S, L517I, S519N, K530R, A534S, A554NC
 CN0326CN0326JQ028413NoneNone  V35T, E36A, T39D, S48T, E53D, V60I, T69S, I135V, I142V, S162C, T200A, Q207E, R211K, V245Q, A272P, K277R, T286A, I293V, D324E, G335D, R356K, G359T, T377M, K390R, A400T, E404D, E432D, V435A, A437V, L452I, R461K, Q464K, H483Y, L484I, L491S, L517I, S519N, K530R, A534S, A554NC
 CN1325CN1325JQ028423NoneNone  V35T, E36A, T39D, S48T, E53D, V60I, T69S, I135V, S162C, Q207E, R211K, V245Q, A272P, K277R, V292I, I293V, V317A, D324E, G335D, R356K, G359A, T377M, T386I, A400T, E404D, E432D, V435A, A437V, L452I, Q464K, H483Y, L484I, L491S, L517I, S519N, A534S, A554NC
Chen (2013)11YNHH01611YNHH016JX412331NoneNone  V35T, E36A, T39D, S48T, E53D, V60I, T69S, D123DE, I135V, I195IT, E204EK, Q207E, R211K, V245Q, A272P, K277R, E291D, V292I, I293VC
 11YNHH11811YNHH118JX412360NoneNone  K20R, E28K, K32E, V35T, E36A, T39D, S48T, E53D, V60I, T69S, I135V, S162C, I178L, Q207E, V245Q, A272P, K277R, E291D, V292I, I293VC
 11YNHH01911YNHH019JX412332NoneNone  V35T, E36A, T39D, S48T, E53D, V60I, T69S, S162C, T200A, I202V, Q207EG, R211RK, V245Q, A272P, K277R, T286A, A288T, V292I, I293VC
 11YNHH12411YNHH124JX412361NoneNone  K20KR, V35T, E36A, T39D, S48T, E53D, V60I, T69S, I135V, S162C, Q174H, T200A, Q207E, R211K, V245Q, A272P, K277R, V292I, I293VC
 11YNHH00611YNHH006JX412326NoneNone  V35T, E36A, T39D, S48T, E53D, V60I, T69S, D123E, I135V, S162C, Q207G, R211K, V245Q, A272P, K277R, E291D, V292I, I293VC
 11YNHH08911YNHH089JX412352NoneNone  K20R, V35T, E36A, T39DE, S48T, E53D, V60I, T69S, I135V, S162C, I178L, Q207E, R211RK, V245Q, A272P, K277R, E291D, V292I, I293VC
 11YNHH09011YNHH090JX412353NoneNone  V35T, E36A, T39D, S48T, E53D, V60I, T69S, I202V, Q207E, R211K, V245Q, D250N, A272P, K277R, T286A, A288T, V292I, I293VC
 11YNHH00511YNHH005JX412325NoneNone  V35T, E36A, T39D, S48E, E53D, V60I, T69S, I135V, Q174H, D177E, I202V, Q207E, R211K, V245Q, A272P, K275R, K277R, E291D, V292IC
 11YNHH00911YNHH009JX412329NoneNone  V35T, E36A, T39D, S48E, E53D, V60I, T69S, V90VI, K101KR, I135V, S162C, V179VI, T200TA, I202V, Q207E, R211K, V245Q, A272P, K277R, T286V, V292I, I293VC
Ferreira (2013)BR09SP106BR09SP106HM534088NoneNone  V35I, T39D, S48T, T69S, K102Q, A158S, K173A, D177DE, V179VI, V189VI, G196R, T200A, I202V, E204D, Q207QK, R211KC
Hawke (2013)9006037990060379KC238219NoneNone  V35T, T39E, S48T, T69S, K122E, D123DG, E138A, K173T, D177EG, T200A, Q207D, R211K, V245Q, D250EC
Li (2013)21062106JQ302613NoneNone V179DK20R, V35T, E36A, T39E, S48T, E53D, V60I, T69S, T107S, D123E, I135V, S162C, D177N, T200A, Q207E, R211K, V245Q, A272P, K277R, E291D, V292I, I293V, A304AE, V317A, D324E, I326M, Q334HN, G335D, R356K, G359T, T377M, T386I, K390R, A400T, E404D, E432D, V435A, A437V, L452I, Q464K, H483Y, L484I, L491S, S519N, K530R, A534S, V548I, A554NC
 21212121JQ302621NoneNone  E6N, V8I, V35T, E36A, T39D, S48T, E53D, V60I, T69S, I132V, I135V, S162C, Q207E, R211K, V245Q, A272P, V276I, K277R, T286A, E291D, V292I, I293V, V317A, D324E, G335D, R356K, G359T, A376S, T377M, K390R, E396D, A400T, E404D, E432D, V435A, A437V, D460N, Q464K, V466I, H483Y, L484I, L491S, S519N, K530R, A534S, A554NC
 21502150JQ302638NoneNone  K20R, V35T, E36A, T39D, S48T, E53D, V60I, T69S, I135V, S162C, Q207E, R211K, V245K, A272P, K277R, V292I, I293V, H315Q, V317A, D324E, G335D, P345Q, F346Y, R356K, G359T, T377M, T386I, K390R, A400T, E404D, E432D, V435A, A437V, L452I, Q464K, V466I, V467I, H483Y, L484I, L491S, S519N, K530R, A534S, Q547E, A554NC
 20632063JQ302586NoneNone V179DE6K, K20R, V35T, E36A, T39D, S48T, E53D, V60I, T69S, T107S, K122E, I135V, S162Y, Q207E, R211K, V245Q, A272P, K277R, V292I, I293V, P313T, V317A, D324E, G335D, R356K, G359AT, K366KR, T377M, T386I, K390R, A400T, E404D, E432D, V435A, A437V, Q464R, V466I, V467VI, H483Y, L484I, L491S, S519N, K530R, A534S, A554QC
 21412141JQ302633NoneNone  K20R, V35T, T39N, S48T, E53D, V60I, T69S, I135V, I142IV, S162C, Q207E, R211K, V245E, A272P, L283I, E291D, V292I, I293V, H315Q, V317A, D324E, G335D, R356K, G359T, K366R, T377M, T386I, A400T, E404D, E432D, V435A, A437V, L452LI, Q464K, H483Y, L484I, L491S, L517I, S519N, K527N, K530R, A534S, A554SC
 20872087JQ302602NoneNone  K20R, V35T, E36A, T39E, S48T, E53D, V60I, T69S, I135V, S162SC, Q207E, R211K, V245Q, E248N, A272P, K275R, K277R, T286A, E291D, V292I, I293V, A304E, V317A, D324E, G335D, R356K, G359T, T377M, T386I, K390KR, A400T, E404D, E432D, V435A, A437V, L452I, Q464K, V466I, H483Y, L484I, L491S, S519N, K527R, K530R, V531I, A534S, A554NC
 21272127JQ302627NoneNone  K20R, V35T, E36A, T39D, S48T, E53D, V60I, T69S, I135V, S162C, Q207E, R211K, V245K, A272P, K277R, V292I, I293V, H315Q, V317A, D324E, G335D, R356K, G359T, T377M, T386I, K390R, A400T, E404D, E432D, V435A, A437V, L452I, Q464K, V466I, V467I, H483Y, L484I, L491S, S519N, K530R, A534S, Q547E, A554NC
 22062206JQ302676NoneNone  V35T, T39N, S48T, E53D, V60I, T69S, D123E, I135T, S162C, Q207E, R211K, V245Q, A272P, K277R, V292I, I293V, V317T, D324E, G335D, R356K, G359AT, T377M, T386V, K390R, A400T, E404D, E432D, V435A, A437V, L452I, Q464K, H483Y, L484I, L491S, S519N, K530R, A534S, A554NC
 22352235JQ302700NoneNone  K20R, V35T, E36A, T39E, S48T, I50V, E53D, V60I, T69S, T107S, S162C, Q207E, R211K, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, V317VA, D324E, G335D, E344EV, R356K, G359T, A376S, T377M, T386I, K390R, A400T, E404D, E432D, V435A, A437V, L452I, Q464K, V466VI, H483Y, L484I, L491S, S519N, K530R, V531I, A534S, A554SC
 21392139JQ302632NoneNone  V35T, E36A, T39D, S48T, E53D, V60I, T69S, V106I, D123E, I135V, S162C, Q207E, R211K, V245Q, A272P, V292I, I293V, E297A, K311Q, V317T, D324E, G335D, G359T, K366R, T377M, T386I, K390R, A400T, E404D, E432D, V435A, A437V, Q464KT, H483Y, L484I, L491S, S519N, K527R, K530R, A534S, A554NC
 20052005JQ302548NoneNone  V35T, E36A, T39D, S48T, E53D, V60I, T69S, I135V, S162C, I178IM, Q207E, R211K, V245Q, A272P, K277R, T286V, E291D, V292I, I293V, V317A, D324E, G335D, R356K, G359T, T377M, T386I, I393IL, A400T, E404D, E432D, V435A, A437V, L452I, Q464K, V466I, H483Y, L484I, L491S, S519N, K527KR, K530R, A534S, A554SC
 22112211JQ302680NoneNone  V35T, E36A, T39D, S48T, E53D, V60I, T69S, V106I, T107S, D123E, I135V, S162C, Q207E, R211K, V245Q, A272P, V292I, I293V, P294T, V317T, D324E, G335D, G359T, K366R, T377M, T386I, K390R, A400T, E404D, E432D, V435A, A437V, Q464K, H483Y, L484I, L491S, S519N, K527R, K530R, A534S, A554NC
 22312231JQ302697NoneNone  K20R, V35T, E36A, T39E, S48T, E53D, V60I, T69S, I135V, S162SC, V179I, I202V, Q207E, R211K, V245H, A272P, K277R, T286A, E291D, V292I, I293V, D324E, G335D, P345Q, R356K, G359T, T377M, T386V, A400T, E404D, E432D, V435A, A437V, L452I, Q464K, H483Y, L484I, L491S, S519N, K527KR, K530R, A534S, A554SC
 20722072JQ302593NoneNone  V35T, E36A, T39D, S48T, E53D, V60I, T69S, V90I, S105A, I135L, S162C, Q207E, R211K, V245Q, A272P, K275R, K277R, T286A, E291D, V292I, I293V, V317A, I329V, G335D, R356K, G359T, T377M, T386I, K390R, A400T, E404D, E432D, V435A, L452I, R461K, Q464K, V466I, H483Y, L484I, L491S, S519N, K530R, A534S, Q547E, A554NC
 22462246JQ302710NoneNone  V35T, T39N, S48T, E53D, V60I, T69S, K102Q, I135V, S162C, E169D, V179I, Q207E, R211K, V245E, A272P, K277R, T286A, V292I, I293V, V317A, D324E, G335D, E344V, R356K, R358K, G359A, K366R, A376AITV, T377M, T386V, K390KR, A400T, E404D, E432D, V435A, A437V, Q464K, V466I, H483Y, L484I, L491S, S519N, A534S, A554SC
 21932193JQ302669NoneNone  V35T, E36A, T39E, S48T, E53D, V60I, T69S, I135L, S162C, Q174R, Q207E, R211K, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, D324E, G335D, R356K, G359T, A376V, T377M, T386I, K390R, A400T, E404D, E432D, V435A, A437V, L452I, Q464K, H483Y, L484I, L491S, S519N, K527R, K530R, A534S, A554NC
 20042004JQ302547NoneNone  V8I, V35T, E36A, T39D, S48T, E53D, V60I, T69S, I135V, S162C, Q207E, R211K, V245Q, D250E, A272P, K275R, K277R, E291D, V292I, I293V, E312A, V317A, D324E, G335D, R356K, G359T, T377M, K390R, A400T, E404D, E432D, V435A, A437V, Q464K, H483Y, L484I, L491S, S519N, K530R, A534S, A554NC
Zeng (2013)cdh47cdh47KC352217NoneNone  V35T, E36A, T39D, S48T, E53D, V60I, T69S, I202V, Q207K, R211KC