<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype C
Gene RT
Mutation T69S
Rx RTI-naive
IncludeMixtures No
References 25
Patients 40
Isolates 40
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Ciccozzi (2005)MC_AY611651C68AY611651NoneNone  V35T, T39K, S48T, T69S, V118I, K122E, D123S, E138A, T200A, Q207K, R211A, F214L, V245Q, E248N, D250E, A272P, K281R, T286A, E291D, V292I, I293V, I326VC
 MC_AY611665C20AY611665NoneNone  V35T, T39K, S48T, T69S, V118I, K122E, D123S, E138A, T200A, Q207K, R211A, F214L, V245Q, E248N, D250E, A272P, K281R, T286A, E291D, V292I, I293V, I326VC
Rousseau (2006)Pt102PS001MB1DQ275648NoneNone  E6K, V35T, E36A, T39E, S48T, V60I, T69S, K122E, D123G, K173T, Q174K, D177E, T200A, Q207G, R211K, V245K, A272P, T286V, E291D, V292I, I293V, V317A, Q334H, G335D, R356K, M357R, G359A, I375V, T377M, K390R, A400T, E404D, I434M, V435A, A437V, L452I, S468T, L469I, D471E, H483Q, L491P, V496I, S519N, Q524E, K530R, A534S, A554SC
Vidal (2007)B108502BU.B1085AM260268NoneNone  V35T, E36A, T39E, E40D, S48T, V60I, T69S, K122E, K173A, D177E, T200A, Q207A, V245M, D250E, A272P, K277R, E291D, V292I, I293V, P294Q, G335E, R356K, G359T, T369V, Q373H, I375V, A376S, T377Q, S379C, K390R, E399D, A400I, E404DC
Lall (2008)G16G16-AFMC8EU158871NoneNone A98GV8I, V35T, E36A, T39D, S48T, V60I, T69S, D121HY, K122E, I135L, I142IT, K166R, K173AT, T200A, Q207K, R211K, V245Q, A272P, K277R, T286A, K287E, E291D, V292I, P294T, Q334H, G335D, R356K, G359T, T377M, K390RC
Matthews (2008)PS001PS001FJ199584NoneNone  E6K, V35T, E36A, T39E, S48T, V60I, T69S, K122E, D123G, K173T, Q174K, D177E, T200A, Q207G, R211K, V245K, A272P, T286V, E291D, V292I, I293V, V317A, Q334H, G335D, R356K, M357R, G359A, I375V, T377M, K390R, A400T, E404D, I434M, V435A, A437V, L452I, S468T, L469I, D471E, H483Q, L491P, V496I, S519N, Q524E, K530R, A534S, A554SC
 PS088PS088FJ199663NoneNone  V21I, V35T, E36A, T39E, S48T, V60I, T69S, K122E, D123G, I135V, K173A, Q174K, D177E, T200A, Q207E, R211K, V245Q, A272P, Q278K, T286A, E291D, V292I, I293V, Q334D, G335D, R356K, G359T, T377L, K390R, E396D, A400M, E404D, V435A, A437V, L452M, Y457D, S468P, T470S, D471E, H483Q, L491S, E492K, S519N, K527R, K528R, K530R, A534S, A554NC
Nyombi (2008)TBK076TBK076EU251763NoneNone  V35T, E36A, T39E, S48T, T69S, K122E, A158S, K166R, K173T, D177E, T200A, Q207E, V245Q, A272Q, K277R, T286A, E291D, V292I, I293V, G335D, F346H, R356K, G359T, T377LC
Bonura (2010)1166_411166_41GU969533NoneNone  T27S, V35T, E36AV, T39E, S48T, P59PS, T69S, V106VI, K122KE, D123DG, S162C, K173A, Q174QK, D177E, G196K, T200A, Q207E, R211K, V245Q, E248D, A272P, L279M, T286TA, E291D, V292VI, I293V, K311KR, D324EC
Gonzalez (2010)LUK6LUK6GQ433854NoneNone  P4S, V35T, E36A, T39E, E40D, S48T, T69S, K122E, D123S, K173T, D177E, T200A, E204K, Q207E, V245Q, D250E, A272P, K277R, T286A, E291D, V292I, I293VC
Ferreira (2011)BRMT2528BRMT2528HQ638705NoneNone V108IV35T, E36A, T39D, T69S, K102Q, D123S, K173T, D177E, I178L, T200A, Q207A, R211KC
Hamers (2011)300153CP076300153HM119728NoneNone  V10VI, K20R, V35T, T39AE, S48T, V60I, T69S, V118I, K122E, D123DEG, K173A, Q174R, D177E, G196E, T200A, Q207E, R211K, F214FL, V245Q, A272P, V292I, I293V, E308KC
 300430CP076300430HM119854NoneNone  V35T, E36A, T39E, S48T, T69S, D121Y, K122E, D123G, S162C, K173A, D177E, I178IV, T200A, E204Q, Q207E, P243S, V245Q, A272P, T286TA, E291D, V292I, I293V, I309FC
 300432CP076300432HM119856NoneNone  V35T, E36A, T39E, S48T, T69S, K122E, A158AS, K173A, Q174HR, T200A, I202V, Q207E, R211RK, V245Q, E248D, D250E, S251D, A272P, K277S, T286A, E291D, V292I, I293V, E297G, N306ST, L325FC
 300444CP076300444HM119866NoneNone  V35T, T39E, S48T, T69S, K122E, D123S, K173T, D177E, T200A, E204K, Q207D, R211RK, V245Q, D250E, A272P, K277R, T286A, E291D, V292I, I293V, L325V, I329G, Q330RC
 CP076300366CP076300366HQ994380NoneNone  I5V, K20R, V35T, E36D, T39R, S48T, K49R, V60I, T69S, L100F, K122E, D123S, I135L, E138A, T139A, K173A, T200A, I202V, Q207E, R211K, F214L, V245Q, A272P, K277R, E291D, V292I, I293V, P294T, E297A, V314AC
 CP076300922CP076300922HQ994541NoneNone  V35T, T39E, S48T, T69S, E89K, L100X, K122E, D123G, E169D, K173A, Q174K, D177E, T200A, Q207E, R211K, V245Q, A272P, K277R, E291D, I293VC
 CP076301053CP076301053HQ994584NoneNone  V10VI, K20R, V35T, T39AE, S48T, V60I, T69S, V118I, K122E, D123DEG, K173A, Q174R, D177E, G196E, T200A, Q207E, R211K, F214FL, V245Q, A272P, V292I, I293V, E308KC
 CP076300938CP076300938HQ994715NoneNoneM41L V35K, T39E, V60I, T69S, K122E, D123S, K173A, D177E, T200A, Q207E, R211K, V245Q, A272P, K275Q, Q278NC
 CP076302703CP076302703HQ994841NoneNone  V35T, T39D, S48T, V60I, T69S, W88C, K122E, S162A, K166R, K173A, D177E, I178IL, T200A, Q207E, R211K, V245Q, A272Q, K277R, T286A, E291D, V292I, I293VC
Nwobegahay (2011)08MB38ZA08MB38ZAGU188775NoneNoneD67E, K70V V35T, E36A, T39E, S48T, I63L, S68P, T69S, W71Q, K122E, D123N, I142V, S162C, K173A, Q174K, D177E, I178L, T200A, Q207E, R211KC
Parboosing (2011)Pat024HRS144HQ844602NoneNone  V35T, E36A, T39E, S48T, V60I, T69S, K122E, D123S, I135V, I142IM, E169D, K173A, Q174K, D177E, I178M, T200A, Q207D, R211K, V245Q, A272P, K277R, T286A, E291D, V292I, I293VC
Tshabalala (2011)SCR385SCR385HQ874346NoneNone  V8I, V35T, E36A, T39E, S48T, T69S, K122E, D123N, K173T, Q174K, T200A, I202V, Q207E, R211K, F214LC
Ferreira (2013)BR09SP106BR09SP106HM534088NoneNone  V35I, T39D, S48T, T69S, K102Q, A158S, K173A, D177DE, V179VI, V189VI, G196R, T200A, I202V, E204D, Q207QK, R211KC
Hawke (2013)9006037990060379KC238219NoneNone  V35T, T39E, S48T, T69S, K122E, D123DG, E138A, K173T, D177EG, T200A, Q207D, R211K, V245Q, D250EC
Nzeyimana (2013)102_1106102_1106HG780792NoneNone  P4S, V35T, E36EA, T39E, K43R, S48T, T69S, K122E, D123S, A158S, K173A, D177E, I178V, T200AE, Q207E, R211RK, V245Q, D250E, S251D, A272P, K277R, T286A, E291D, V292I, I293V, E297A, G335D, R356K, G359T, T377M, K390R, A400T, E404DC
 102_1268102_1268HG780842NoneNone  V35T, E36A, T39E, E40D, S48T, T69S, K122E, D123S, K173A, Q174QR, T200E, I202V, Q207N, V245Q, D250E, A272P, K277R, T286A, E291D, V292I, I293V, V317VA, Q334E, R356RK, G359T, T377Q, K390R, A400AT, E404DC
 201_1894201_1894HG780732NoneNone  V35T, E36A, T39E, S48T, T69S, A158S, K173A, Q174K, D177E, G196E, T200A, Q207E, V245Q, A272S, K281R, T286A, E291D, V292I, I293V, V314A, Q334N, G335D, R356K, M357T, G359A, T377L, K390R, E404D, W414WG, E430KC
 201_4373201_4373HG780641NoneNone  K20R, V35T, E36A, T39E, S48T, T69S, K122E, D123N, K173A, D177E, Q197K, T200A, Q207E, P243S, V245Q, D250E, S251D, A272P, K277R, T286A, E291D, E297A, G335D, R356K, G359T, V365I, K366R, T377M, K390R, A400T, E404D, E413D, N418SC
Moura (2015)BRMA_248BRMA_248KF782764NoneNone  V35T, E36A, T39E, S48T, T69S, I135T, E138A, K173A, Q174K, D177E, V179I, T200A, Q207E, R211KC
Neogi (2015)11SJ107111SJ1071KP307219NoneNone  K11Q, V35T, T39N, V60I, I63L, T69S, F77G, R78S, K102Q, D121Y, K122E, S162A, T165I, K173T, D177E, Q197H, T200A, Q207E, R211KC
Novitsky (2015)bcpp_030bcpp_030KR860616NoneNone  V35T, E36A, T39E, S48T, T69S, K122E, S162T, K166R, K173A, D177E, T200A, Q207R, R211K, V245Q, E248D, A272P, I274V, T286A, E291D, V292I, I293V, I326V, I329V, Q334H, G335D, R356K, M357R, G359T, A360T, A371V, T377M, K390R, A400T, E404D, V435T, A437V, L452M, K454R, D471E, H483Q, L491S, S519N, K530R, A534S, A554SC
Wang (2015)1210012100KM395810NoneNone  K22N, V35A, E36A, T39D, S48T, V60I, T69S, G99E, D121Y, K122E, S162C, K173I, Q174K, D177E, E203G, Q207K, R211N, V245E, I274VC
Amogne (2016)ET174ET174KU319728NoneNone  V35T, E36A, T39E, E40D, S48T, V60VI, T69S, K122E, D123S, I135IR, K173A, Q174K, D177E, I178M, T200A, Q207E, R211KC
 ET118ET118KU319686NoneNone  K20R, V35T, E36A, T39E, S48T, T69S, K122E, D123S, I135T, A158S, T165I, K173A, D177E, T200A, E204D, L205*, R211KC
 ET160ET160KU319716NoneNone  V35T, E36A, C38W, T39E, S48T, T69S, K122E, D123S, T128S, K166R, F171FS, K173A, D177E, G196KNRS, T200A, Q207E, R211RKC
Baudi (2016)Zi14-076Zi14-076KX648614NoneNone  V35T, E36A, T39A, S48T, T69S, K122E, D123S, S162C, K173A, D177E, V179VI, T200A, Q207E, R211RKC
Karade (2016)N14-0497N14-0497KT318906NoneNone  K32E, V35T, E36A, T39N, S48T, V60I, T69S, D121Y, K122E, I135R, S162A, K173A, D177E, Q207E, R211K, V245Q, D250T, S251DC
Lima (2016)BRGO6016BRGO6016KC249750NoneNone  V35T, E36A, T39D, K43R, S48T, T69S, E138A, L149LP, S162C, K173T, D177E, I178V, V179I, T200A, Q207E, R211KC
Steegen (2016)GFECA012GFECA012KT893040NoneNone  K20KR, K22R, V35T, S48T, V60I, T69S, W88WC, K122E, D123G, S162Y, K173T, Q174K, D177E, T200A, Q207A, R211K, F214L, V245Q, A272P, Q278H, K281R, T286A, V292I, I293V, Q334D, G335D, R356K, G359T, K366R, T377L, K390R, A400T, E404DC