<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype C
Gene RT
Mutation T69N
Rx >= 1 NRTI
(but no NNRTI)
IncludeMixtures No
References 9
Patients 33
Isolates 33
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Cuevas (2002)CU81CU81AF425462AZT, DDINoneD67N, K70R V35T, T39E, K64R, T69N, A98S, D121H, K122E, D123S, K173A, D177E, I178L, I195M, Q197P, T200A, Q207EC
Kantor (2002)TCDD-03TCDD-03AY090842DDI, AZTNoneD67N, K70R, F77FL, Q151M, T215TI, K219EQ V35T, E36A, T39D, S48T, T69N, K122E, D123N, P140Q, I142X, R143X, Y144X, S162A, K173T, Q174QK, D177E, T200A, Q207E, R211K, L228HRC
Non-B Workgroup (2005)SA63_10701070A_12MAY589806AZT, D4T, DDINone  V35T, T39E, T69N, K122E, D123G, K173T, Q174K, T200A, Q207E, R211K, V245Q, A272P, K277R, T286A, E291D, V292I, I293VC
 SA65_1158SA65_1158AY589817D4T, DDINone  K20R, V35T, E36A, T39E, S48T, T69N, K122E, D123N, K166R, K173T, D177E, I178M, T200A, E204K, Q207E, V245L, A272P, K277R, E291D, V292I, I293V, P294TC
 SA67_1216SA67_1216AY589823D4T, DDINone  V35T, E36A, T39E, S48T, T69N, K122E, D123G, K173T, T200A, Q207E, V245H, K277R, T286A, E291D, V292I, I293VC
 SA70_1529SA70_1529AY589835DDI, D4TNone  V35T, T39E, S48T, T69N, K122E, K173A, T200A, Q207A, R211K, V245Q, T286A, E291D, V292I, I293VC
 IL293IL293AY901766AZT, 3TC, DDINoneK70R, M184V T39E, K64R, T69N, A98S, K122E, D123S, A158S, K173A, D177E, T200A, Q207EG, H208HY, R211K, H235HY, V245QC
Rodrigues (2005)BLF_Pat10BR03SP09AY643230AZTNone  V35T, T39D, T69N, K122E, K173A, Q174K, D177E, T200A, Q207E, R211K, V245Q, K277R, E291D, V292I, I293V, P294TC
Deshpande (2009)Pat24814artFJ530693AZT, 3TCNoneD67N, K70R, M184V, T215F, K219EA98AGV35T, T39E, S48T, V60I, T69N, V118I, D121H, K122E, I135T, K173AT, D177E, I178M, T200A, E204K, Q207E, F214L, E224D, V245QC
 Pat21316RTFJ530728AZT, 3TCNoneM41L, D67N, K70R, M184V, T215F, K219QA98G, K101EQ, G190AK20R, E28EK, V35T, T39D, E44D, S48T, V60I, T69N, D121H, K122E, F124FV, I135T, K173A, Q174R, I178M, T200A, Q207E, R211RK, V245Q, L246WC
Van Zyl (2013)377211.ZA.EC114KC423725AZT, DDINone  K22R, V35T, E36EA, T39D, S48T, V60I, T69N, W88C, K104R, K122E, D123S, I135T, S162Y, K173T, T200A, Q207E, R211K, V245QC
 358009.ZA.GT848KC424344D4T, 3TCNoneA62AV, M184V V35T, E36A, T39E, E40D, S48T, T69N, K122E, D123N, I135V, I159IV, K173T, Q174K, D177E, G196E, Q207D, R211K, K219KT, P243T, V245QC
 17512.ZA.NL028KC423893TDF, AZT, 3TCNoneK70R, M184V, K219QL100I, K103NT27S, V35T, T39E, S48T, T69N, K122E, D123N, A158AS, T165L, K173M, Q174R, T200A, I202V, Q207E, R211K, F214L, L228RC
 397312.ZA.GT2227KC423895ABC, 3TCNone  E28R, K32E, V35T, E36A, T39E, S48T, V60I, T69N, K122A, G155V, K173T, D177E, T200A, Q207E, V245QC
 311606.ZA.GT055KC424309D4T, 3TCNoneM184V K22KN, V35T, E36A, T39E, S48T, T69N, K122E, T128S, I135V, S162C, K173A, Q174K, D177E, I178M, T200A, E204D, Q207D, R211K, V245Q, D250E, A272P, T286V, E291D, V292I, I293VC
 339107.ZA.GT317KC424108D4T, 3TCNoneM184VY181CP4PS, K22KR, V35T, T39EK, S48T, T69N, K122KE, A158S, K173A, D177E, T200A, Q207E, V245QC
 366610.ZA.GT1225KC423069D4T, 3TCNone Y181CV35T, T39E, S48T, T69N, K122E, D123N, K173T, Q174K, T200A, Q207A, R211K, V245QC
 14212.ZA.NL013KC423795TDF, AZT, 3TCNone K103N, Y181CP4S, V35K, E36A, T39E, K43Q, V60I, T69N, K102Q, K122E, D123N, I142V, S162C, K173A, Q174N, D177E, T200A, Q207E, R211K, D218E, L228R, V245QC
 87111.ZA.WC144KC423424AZT, 3TC, DDINone  K11Q, K20R, E36A, T39E, S48T, T69N, D121Y, K122E, D123G, I135T, S162C, K173A, Q174R, T200A, Q207E, R211K, V245QC
 272811.ZA.GT1577KC423970AZT, DDI, 3TC, TDFNone  V35T, T39E, S48ST, T69N, K122E, D123DN, S162C, K173T, Q174K, D177E, I178L, T200A, Q207E, R211K, V245QC
Acharya (2014)DGP121DGP121KJ185291AZT, 3TCNoneM41L, D67N, K70R, V75M, T215F, K219QV106M, V108I, G190AV35T, E36A, T39E, S48T, V60I, T69N, K101R, K122E, I135T, S162A, K166R, K173A, D177E, G196R, T200A, Q207A, V245Q, A272P, K277R, E291D, V292I, I293VC
 DGP060DGP060KJ185230TDF, 3TCNoneK70R V35T, E36A, T39E, S48T, V60I, T69N, K122E, D123S, I135T, K166R, K173A, D177E, T200A, Q207E, R211K, V245Q, A272P, K277R, K281R, E291D, V292I, I293VC
Neogi (2016)69413.ZA.EC880KT592949ABC, 3TCNone Y181YCV21VI, V35T, T39R, S48T, T69N, K122E, D123G, S162C, K173A, D177E, T200A, Q207E, V245QC
 714313.ZA.EC707KT592854D4T, 3TCNoneD67N, K70R, M184V, L210LW, T215F, K219EY188LI2V, V8I, V35K, T39E, S48T, V60I, T69N, A98S, V118VI, D121H, K122E, K173T, Q174K, D177E, V179VI, T200E, E203K, Q207E, H208HY, D218E, V245QC
 422513.ZA.GT2765KT593122AZT, 3TCNoneK65RK103N, Y181CV35T, T39N, S48T, V60I, T69N, K122E, D123S, K173A, Q174K, D177E, Q207R, R211S, V245QC
 14513.ZA.NL081KT593453TDF, 3TCNoneM184VY181CP4S, V35T, T39E, S48T, V60I, S68G, T69N, D121Y, K122E, I135R, T139R, S162C, K173A, V179I, T200A, Q207D, R211K, F214L, H221Y, D237DN, V245QC
 322713.ZA.GT2920KT593231AZT, 3TCNoneK70R, K219KQA98G, Y181CV35T, E36A, T39E, S48T, T69N, K101Q, K122E, K173A, Q174K, D177E, T200A, Q207T, R211K, F214L, L228R, V245Q, D250EC
Posada Cespedes (2017)710512.ZA.EC474KX541925AZT, 3TCNone K101E, Y181C, G190AV35I, S48T, T69N, D86E, K122E, D123S, I135T, E138Q, S162C, K173A, Q174R, D177E, V189I, T200E, Q207E, R211K, V245QC
 458614.ZA.GT3677KX544494D4T, 3TCNoneM184VV106M, G190A, M230LT58X, P59X, V60I, T69N, K122E, D123G, K166R, K173E, Q174R, D177E, I178M, Q207E, R211K, V245Q, S251NC
 450314.ZA.WC554 ABC, 3TCNone Y181CV35T, E36A, T39D, S48T, V60I, T69N, K173A, Q174K, T200A, Q207E, R211K, V245QC
 63714.ZA.EC932KX544047AZT, 3TCNoneD67S, K70R, M184V, T215F, K219QV108VI, Y181V, M230LV35T, T39E, K46Q, V60I, T69N, A98S, V106I, K122E, D123S, S163ST, K173A, D177E, T200A, Q207E, R211K, D218E, L228H, V245QC
 713613.ZA.EC632KX542671ABC, 3TCNoneM184MVK103N, Y181CV35T, E36T, T39E, S48ST, T69N, K122E, D123S, S162C, K173A, D177E, T200A, Q207E, R211RK, L228H, V245QC
 328413.ZA.GT2987KX543282AZT, DDI, D4T, 3TC, TDFNoneD67G, K70R, M184V, K219E E6D, V35T, T39E, T69N, W88C, V118I, K122E, D123N, I135T, E138G, A158S, K173T, Q174K, V179IT, T200E, I202V, E203K, R211K, F214LC