<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype C
Gene RT
Mutation T69D
Rx >= 1 NRTI
(but no NNRTI)
IncludeMixtures No
References 11
Patients 25
Isolates 27
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Venturi (1999)GV-22Vent22BAF169084AZTNoneD67N, T69D, T215Y V35T, T39E, S48T, D121H, K122E, D123S, A158S, S162T, K173T, D177E, T200A, Q207EC
  Vent22W24AF169085AZT, DDCNoneD67N, T69D, K70R, T215DY V35T, T39E, S48T, D121H, K122E, D123S, A158S, S162T, K173T, D177E, T200A, Q207EC
Non-B Workgroup (2005)SA75_DR16SA75_DR16AY901709ABC, AZT, 3TCNoneM41L, D67N, T69D, M184V, L210W, T215FA98GV35T, T39E, E44D, S48T, E53D, V111I, V118VI, D121DG, K122E, D123S, E138EA, K173A, Q174K, D177E, G196E, T200A, E203V, Q207E, H208Y, R211K, V245Q, E248D, A272P, K277R, T286A, E291D, V292I, I293VC
Pillay (2008)DR71DR71AY589920D4T, DDINoneT69D V35T, E36A, T39E, S48T, K122E, D123G, K173T, Q174K, T200A, Q207E, V245Q, A272P, K275R, Q278H, T286TA, E291D, V292I, I293V, D324EC
 DR1602ZA.DR16AY589877ABC, AZT, 3TCNoneM41L, D67N, T69D, M184V, L210W, T215FA98GV35T, T39E, E44D, S48T, E53D, V111I, V118VI, D121DG, K122E, D123S, E138EA, K173A, Q174K, D177E, G196E, T200A, E203V, Q207E, H208Y, R211K, V245Q, E248D, A272P, K277R, T286A, E291D, V292I, I293VC
Deshpande (2009)Pat034352RTFJ530907AZT, 3TCNoneM41L, D67N, T69D, M184V, T215Y V35K, T39D, E44D, S48T, V60I, K101R, K102KN, D121Y, K122E, I135T, S162A, K173A, Q174R, D177DE, T200A, E203D, Q207E, R211K, L228Q, V245QC
 Pat004447RTFJ530937AZT, 3TCNoneM41L, D67N, T69D, K70R, M184V, T215Y V35T, T39D, V60I, D121Y, K122E, I135V, K173A, D177E, T200A, Q207E, R211K, V245QC
Rodrigues (2010)301_07BR07SC301GQ4013143TCNoneM41L, D67N, T69D, M184V, L210W, T215C I5V, V35T, E36A, T39D, K43R, E44D, V118I, K122E, D123S, I135T, K173T, D177E, T200A, E203D, Q207E, H208Y, R211KC
Van Zyl (2013)38410.ZA.WC073KC423019ABC, AZT, 3TCNoneM41L, T69D, L210W, T215YG190AV35T, T39N, S48T, V60I, F116S, K122E, D123N, I135T, K173A, Q174K, T200A, Q207E, R211K, V245QC
 40108.ZA.WC014KC423987D4T, 3TCNoneD67N, T69D, K70KR, M184V K20KR, E28K, K32E, V35T, E36A, T39E, S48ST, K122E, D123GS, I135T, K173T, D177E, V179VI, T200A, Q207E, V245KC
 327211.ZA.GT1915KC423704AZT, 3TC, DDINoneD67N, T69D, K70R, V75I, T215F, K219Q V35T, T39E, V60I, W88C, K122E, I132L, K173A, D177E, I178L, G196E, T200A, K201R, E203ED, E204K, Q207E, F214L, L228R, V245Q, E248DC
 11411.ZA.WC124KC423355AZT, 3TCNoneD67N, T69D K20R, V35T, T39D, N81F, K82I, K122E, D123S, I135T, T165TI, K173A, Q197P, T200A, Q207E, R211K, V245LQC
Acharya (2014)DGP162DGP162KJ185332TDF, 3TCNoneM41L, D67N, T69D, K70R, L74I, M184V, T215F, K219QY181I, G190SV35T, T39D, S48T, V60I, D121H, K122E, K173A, Q174R, D177E, I178L, Q197K, T200A, Q207E, R211K, V245Q, A272P, K277R, E291D, V292I, I293V, P294TC
 DGP113DGP113KJ185283TDF, 3TCNoneM41L, D67N, T69D, M184V, L210W, T215FK101E, K103NV8I, V35T, T39D, S48T, V60I, D121Y, K122E, I135T, K173A, Q174R, D177E, I178L, T200A, Q207E, R211K, V245Q, A272P, K277R, T286A, E291D, V292IC
Steegen (2014)12ZAKS26112ZAKS261KJ176540TDF, D4T, 3TCNoneM41L, D67N, T69D, K70R, V75M, M184V, T215FK103N, V106MV35T, E36EA, T39AE, S48T, K49R, V60I, K122E, I135T, T139K, S162SN, K173T, Q174K, D177E, I178M, T200A, E203K, Q207E, H208Y, R211K, W212M, F214L, K223E, P243S, V245K, K249Q, A272P, E291D, I293V, P313PS, V317VA, S322A, Q334N, G335D, A355S, R356K, R358K, G359N, A376S, T377L, K390R, E399D, A400I, T403A, E404DC
Chimukangara (2016)NC15NC15KU508560TDF, FTC, 3TCNoneD67N, T69D, K70R, M184V, T215F, K219EK103S, Y181C, G190AV35K, E36A, T39E, S48T, V60I, K102R, V118I, K122E, D123G, S162N, K173T, D177E, V179I, T200A, I202V, R206K, Q207E, R211K, F214L, L228HC
Neogi (2016)711413.ZA.EC517KT592727TDF, 3TCNoneD67G, T69D, K70R, M184V, K219QL100I, K103NK20R, V35T, T39E, V60I, V106VL, K122E, D123G, I135V, T139Q, I142T, K173A, D177G, V179N, T200A, E203K, Q207E, L228H, V245QC
Posada Cespedes (2017)413412.ZA.GT2373KX542200AZT, 3TCNoneD67N, T69D, K70R, T215F, K219EK103N, V106M, Y181C, F227LK20R, E28*K, V35T, E36A, C38*, T39E, S48T, V60I, K122E, D123S, E138A, P157A, K173A, Q174R, D177E, T200A, I202V, E203A, Q207A, R211K, F214L, K223N, L228R, V245QC
 45312.ZA.WC254KX542519AZT, 3TCNoneD67G, T69D, K70R, M184V, K219QK101P, K103N, P225HP4S, K20R, E28K, K32R, V35T, T39E, S48T, V60I, A98S, K122E, D123S, S162H, K166R, K173S, D177G, T200A, I202V, E203K, Q207E, R211K, V245QC
 416015.ZA.GT4343 TDF, 3TCNoneD67G, T69D, K70R, V75M, M184V, T215I, K219QV106M, Y181C, F227LI31L, L34I, V35T, T39E, S48T, V60I, K82R, K122E, D123S, I135R, T165I, K173A, Q174K, D177E, T200A, Q207E, R211K, F214L, V245QC
 419314.ZA.GT3578KX544413TDF, 3TCNoneD67N, T69D, M184V, T215FA98G, K103N, Y181CK20R, V35T, T39E, V118I, K122E, D123S, I135T, K173A, T200E, E203D, E204Q, Q207A, R211K, L228LH, V245Q, E248DC
 574915.ZA.EC1647 AZT, DDINoneT69D K11Q, T27S, V35T, E36A, T39E, S48T, V60VI, S68G, D121Y, K122E, D123GS, I135T, E138A, S162C, K173E, T200A, Q207E, R211K, V245QC
 528811.ZA.EC048KX540935ABC, AZT, 3TCNoneT69D, K70R K20KR, V35T, T39E, S48T, V60I, K122E, D123G, K173T, D177E, I178M, T200A, Q207E, L228R, V245QC
 151514.ZA.GT3236KX544142TDF, 3TCNoneD67G, T69D, K70R, V75M, M184V, T215I, K219KQV106M, Y181C, F227LI31L, L34I, V35T, T39E, S48T, V60I, K82R, K122E, D123S, I135R, T165I, K173A, Q174K, D177E, T200A, Q207E, R211K, F214L, V245QC
 253208.ZA.GT466KX539941ABC, DDINoneM41L, D67N, T69D, K70R, M184V, T215F, K219QY181IP4S, V35T, E36A, T39E, S48T, K49R, V60I, K122E, D123N, I135M, S162D, E169A, K173AT, Q174K, V179I, T200A, I202V, Q207E, R211K, F214L, L228H, K238R, V245Q, E248DC
 11413.ZA.WC358KX543624AZT, 3TC, TDFNoneK65KR, D67N, T69D K20R, V35T, T39D, K122E, D123S, I135T, T165I, K173A, Q197P, T200A, Q207E, R211K, V245QC
 87112.ZA.WC266 AZT, 3TC, DDI, TDFNoneD67N, T69D K11Q, K20R, E36A, T39E, S48T, D121Y, K122E, D123G, I135T, S162C, K173A, Q174R, T200A, Q207E, R211K, V245QC