Reverse Transcriptase Inhibitors

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Reverse Transcriptase Inhibitors

Subtype	C
Gene	RT
Mutation	D67N
Rx	>= 1 NRTI (but no NNRTI)
IncludeMixtures	No

References	15
Patients	43
Isolates	46

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	NRTIs	NNRTIs	NRTIDRMs	NNRTIDRMs	OtherMut	Subtype
Venturi (1999)	GV-22	Vent22B	AF169084	AZT	None	D67N, T69D, T215Y		V35T, T39E, S48T, D121H, K122E, D123S, A158S, S162T, K173T, D177E, T200A, Q207E	C
		Vent22W24	AF169085	AZT, DDC	None	D67N, T69D, K70R		V35T, T39E, S48T, D121H, K122E, D123S, A158S, S162T, K173T, D177E, T200A, Q207E, T215X	C
Yahi (2001)	NY_M3	M3	AY010476	DDC, 3TC	None	D67N, K70R, M184V, K219Q		K20KR, V35T, E36A, T39E, E40D, K43R, T69TN, K122E, D123S, A158S, K173A, Q174QR, D177DE, T200A, E203EK, Q207E, R211K, F214L, D218DE, L228H	C
Cuevas (2002)	CU81	CU81	AF425462	AZT, DDI	None	D67N, K70R		V35T, T39E, K64R, T69N, A98S, D121H, K122E, D123S, K173A, D177E, I178L, I195M, Q197P, T200A, Q207E	C
	CU39	CU39	AF425420	AZT	None	D67N		V35T, T39E, S48T, A98S, K122E, D123N, A158S, K173A, Q174K, D177E, T200A, F214L	C
Snoeck (2002)	BE16a	BE16a	AF339010	AZT, 3TC	None	D67N, K70R, M184V, K219Q		V35T, T39N, S48SL, V60I, P119PL, D121DH, K122KE, D123DGNS, R125RG, I135R, N136NT, K173I, Q174K, D177E, T200A, Q207E, R211K, F214L	C
Weber (2003)	85H	610185H-12	AY140821	NRTI, AZT, 3TC	None	M41L, D67N, L210W, T215Y		V35T, T39E, S48T, A98S, K122E, D123N, I135T, K173T, Q174K, T200A, Q207N, R211K, V245Q, A272Q, E291D, V292I, I293V	C
		610185H-48	AY140823	NRTI, AZT, 3TC	None	M41L, D67N, M184V, L210W, T215Y		V35T, T39E, S48T, A98S, V118I, K122E, D123N, I135T, K173T, Q174K, N175Y, G196E, T200A, Q207N, R211K, V245Q, A272Q, E291D, V292I, I293V	C
Montes (2004)	MB_patMUK	03_MUK733	AJ577958	DDI, AZT, D4T, 3TC	None	D67N, K219Q		K20G, V35T, E36A, T39E, K103R, K122E, D123S, I135T, K173A, D177E, I178V, T200V, E203K, Q207E, R211K, F214L	C
Richard (2004)	RNJCR09	RNJCR09	AY556758	AZT, 3TC, D4T, DDI	None	M41L, D67N, K70R, M184V		P4T, V35T, T39E, K122E, D123S, A158S, K173A, D177E, T200A	C
Snoeck (2004)	BE60	BE60	AY901312	AZT, 3TC	None	D67N, K70R, M184V		V35T, T39E, S48T, K122E, D123N, I135IT, A158S, K173T, D177E, T200A, Q207EK, V245Q, A272P, K277R, T286A, E291D, V292I, I293V	C
Non-B Workgroup (2005)	UK1518	UK1518	AY901342	AZT, 3TC	None	D67N, K70R, M184V		V35T, E36A, T39E, S48T, K122E, D123S, I135T, S162NY, K173T, D177E, T200X, Q207K	C
	IL80	IL80	AY901353	AZT, DDI, DDC, D4T, ABC, 3TC	None	M41L, D67N, M184V, L210W, T215Y	A98G	T39E, S48T, V60I, G112X, P119PH, K122E, D123A, F124I, A158S, K173A, Q174K, D177E, T200A, Q207E, R211K, V245Q	C
	IL128	IL128e	AY901356	AZT, 3TC, DDI	None	M41L, D67N, K70R, T215Y	Y181S	T39E, E44D, V118VI, K122E, D123S, I135T, W153L, S163C, K173T, D177E, T200A, Q207E, K223KR, Y232*, W239R	C
	UK1998	UK1998	AY901375	ABC, AZT, 3TC	None	D67N, K70R, M184V		V35T, T39K, S48T, K122E, D123E, K173T, Q174K, D177E, T200E, Q207D, R211K	C
	UK2034	UK2034	AY901387	AZT, DDI	None	D67N, K70R, K219KQ		V35T, E36A, T39E, S48T, K103KR, K122E, D123S, I135V, I159V, T165I, K173T, D177E, T200A, E203K, E204EK, Q207E, R211K, D218DE, W229WG	C
	UK2109	UK2109	AY901401	ABC, AZT, 3TC	None	D67N, K70R, M184V		K20R, V35T, T39E, K43KR, S48T, K104R, K122E, D123N, I135T, E138A, K173I, Q174K, I195IM, T200A, E203EK, Q207E, L210LM, R211K, F214L	C
	SA75_DR16	SA75_DR16	AY901709	ABC, AZT, 3TC	None	M41L, D67N, T69D, M184V, L210W, T215F	A98G	V35T, T39E, E44D, S48T, E53D, V111I, V118VI, D121DG, K122E, D123S, E138EA, K173A, Q174K, D177E, G196E, T200A, E203V, Q207E, H208Y, R211K, V245Q, E248D, A272P, K277R, T286A, E291D, V292I, I293V	C
	SA84_DR29	SA84_DR29	AY901717	AZT, 3TC	None	D67N, K70R, K219Q	K103N, G190A	V35T, E36A, T39E, S48T, V60I, K122E, D123G, V148VG, K173A, D177E, T200A, E203Q, Q207E, H221Y, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, V317A	C
	IL477	IL477	AY901780	D4T, DDI	None	M41L, D67N, L210W, T215Y		S48T, K65KE, V118VI, K122E, D123S, I135IT, K173T, D177E, T200A, Q207E, R211RK, V245Q	C
	TK3015	TK3015		AZT, 3TC, DDC	None	M41L, D67N, L210W, T215Y		V35M, T39D, E44D, V118I, K122E, I135L, K173A, Q174K, N175Y, D177E, V179A, E194K, G196E, T200A, I202V, Q207E, R211K, V245Q, D250E, I257V, A272S, T286A, K287X, E291D, V292I, I293V, H315F	C
	TK3027	TK3027		D4T, 3TC	None	D67N, M184V, T215Y		V35T, T39E, S48T, K122E, D123DG, I135LM, T165I, K173A, D177E, I178V, T200A, I202V, E204K, Q207D, R211K, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, V317A	C
Weber (2005)	F56949	F56949	AY677552	DDC, AZT, D4T, DDI, TDF	None	M41L, D67N, L210W, T215Y		V21I, V35T, E36A, T39E, S48T, V118I, K122E, D123G, K173A, D177E, T200A, Q207E, R211K, V245Q, A272P, I274V, Q278H, K281R, T286A, E291D, V292I, I293V, K311R	C
	M83284	M83284	AY677581	D4T, DDI, ABC, AZT, 3TC	None	D67N, K70R, M184V, T215FY, K219W		S48T, V60I, D121H, K122E, D123S, I142V, S162X, K173T, Q174R, D177E, I178L, T200A, Q207E, R211K, A272P, K277R, T286A, E291D, V292I, I293V, V317DN	C
	M66914	M66914	AY677584	AZT, DDI, 3TC, D4T	None	D67N, K70R, M184V, T215V, K219Q		V21I, V35T, T39E, K43R, T69TS, K122E, D123S, I135V, K173T, Q174K, D177E, Q207E, V245Q, K249Q, A272P, T286A, E291D, V292I, I293V	C
Marconi (2008)	SW083	sw083	EU308093	D4T, DDI	None	M41L, D67N, V75VA, T215Y		E44ED, S48T, K65KM, V118VI, K122E, D123G, S162Y, K173T, Q174R, D177E, T200A, E203EK, Q207E, R211K, V245Q	C
Pillay (2008)	DR15	DR15	AY589875	AZT, DDI	None	D67N, K70R, K219E		K20R, V35T, T39K, S48T, V60I, V118I, K122E, D123N, A158S, S162G, K173T, Q174A, T200A, E203EK, Q207E, R211K, F214L, V245Q, D250E, S251D, A272P, K277R, Q278E, E291D, V292I, I293V, E297K	C
	DR37	DR37	AY589894	AZT, D4T, 3TC, DDI, ABC	None	D67N, K70R, L74IV, M184V, K219KE		V35M, T39D, S48T, V60VI, D123DN, K173A, Q174K, T200A, E203K, Q207E, R211K, V245Q, K249KQ, D250E, A272P, K277R, E291D, V292I, I293V	C
	DR60	DR60	AY589912	AZT, D4T, DDI	None	M41L, D67N, L210W, T215Y		P4T, K20R, T27S, V35T, T39E, S48T, V60I, V118I, K122E, D123S, E138A, K173T, Q174K, T200A, Q207E, R211K, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, P294PQ	C
	DR16	02ZA.DR16	AY589877	ABC, AZT, 3TC	None	M41L, D67N, T69D, M184V, L210W, T215F	A98G	V35T, T39E, E44D, S48T, E53D, V111I, V118VI, D121DG, K122E, D123S, E138EA, K173A, Q174K, D177E, G196E, T200A, E203V, Q207E, H208Y, R211K, V245Q, E248D, A272P, K277R, T286A, E291D, V292I, I293V	C
	DR76	03ZA.DR76	AY589922	D4T, DDI	None	D67N, K70R, K219Q		V35T, E36A, T39E, K64KN, K122E, D123DG, K173A, Q174K, D177E, I178L, T200A, Q207KN, L210LF, R211KM, V245Q, A272P, K277R, Q278H, T286A, I293V	C
	DR81	03ZA.DR81	AY589925	D4T, DDI	None	M41L, D67N, T215Y		K11Q, V35T, T39E, S48T, V60I, K101Q, V118I, D121Y, K122E, D123G, I142V, S162C, K166R, K173A, D177E, T200A, Q207E, R211K	C
	DR88	03ZA.DR88	AY589928	D4T, DDI	None	M41L, D67N, L210W, T215Y		V35T, T39E, S48T, V60I, F77FS, G93GR, K101T, F116FL, V118I, S134I, K173A, D177E, T200A, Q207E, R211K, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, V317A	C
Sylla (2008)	B7173	B7173_C1	EF525661	3TC, DDI	None	D67N, M184I		V35T, T39E, S48T, V60I, A98S, D121H, K122E, I135V, K173A, Q174K, P176T, I178L, T200A, Q207E, R211K, V245M, D250E, A272P, K277R, T286A, E291D, V292I, I293V, D324E, Q334H, G335D, R356K, G359T, T377M, K390R, A400T, E404D	C
		B7173_C2	EF525662	3TC, DDI	None	D67N, L74V, M184I		V35T, T39E, S48T, V60I, A98S, D121H, K122E, I135V, K173A, Q174K, P176T, I178L, T200A, Q207E, R211K, V245M, D250E, A272P, K277R, T286A, E291D, V292I, I293V, D324E, Q334H, G335D, R356K, G359T, T377M, K390R, A400T, E404D, V435VI	C
Deshpande (2009)	Pat248	14art	FJ530693	AZT, 3TC	None	D67N, K70R, M184V, T215F, K219E	A98AG	V35T, T39E, S48T, V60I, T69N, V118I, D121H, K122E, I135T, K173AT, D177E, I178M, T200A, E204K, Q207E, F214L, E224D, V245Q	C
	Pat234	35art	FJ530707	AZT, 3TC	None	M41L, D67N, M184V, T215Y		V35T, T39D, E44D, V60I, V90I, D121Y, K122E, S162Y, K173T, Q174K, D177E, I178L, T200A, Q207E, L210S, R211K, V245Q	C
	Pat213	16RT	FJ530728	AZT, 3TC	None	M41L, D67N, K70R, M184V, T215F, K219Q	A98G, K101EQ, G190A	K20R, E28EK, V35T, T39D, E44D, S48T, V60I, T69N, D121H, K122E, F124FV, I135T, K173A, Q174R, I178M, T200A, Q207E, R211RK, V245Q, L246W	C
	Pat209	20RT	FJ530732	D4T, 3TC, AZT	None	M41L, D67N, L74IV, M184V, L210W, T215Y, K219KN	A98G, K101E, V108I, Y181CFGV	K20R, K32T, V35K, T39D, E44D, S48T, V60I, V118I, D121Y, K122E, I135R, S162A, K173ST, V189I, T200A, E203V, Q207E, R211K, K223Q, T240K, V245Q	C
	Pat183	69RT	FJ530758	AZT, 3TC, D4T	None	D67N, K70R, M184V, K219Q	V106M, G190A	T27S, V35T, E36A, T39D, S48T, V60I, T69S, D121Y, K122E, I135T, E138Q, S162A, K166R, K173A, D177E, V179I, G196K, Q197R, R199RG, T200A, Q207G, R211K, F214L	C
	Pat044	327	FJ530897	AZT, 3TC	None	M41ML, D67N, K70R, V75M, M184AV, T215F, K219E	G190A	L12I, V35T, T39N, V60I, T69TN, D121HY, K122E, I135M, S162SN, K173A, D177E, V179I, E203EV, Q207E, L228H, V245Q	C
	Pat043	329	FJ530898	AZT, 3TC	None	M41L, D67N, K70R, V75M, M184V, T215F, K219E	G190A	V35T, T39N, V60I, D121H, K122E, I135M, K173T, D177E, V179I, Q207E, L228H, V245Q	C
	Pat042	336	FJ530899	AZT, 3TC	None	D67N, K70R, M184V, T215FI, K219E	K103KN, Y181YC, G190A, K238KT	T27TS, V35T, T39D, E40ED, V60I, L109I, D121H, K122E, I135T, K166R, K173T, Q174R, D177E, T200A, I202V, Q207E, R211K, L228H, V245Q	C
	Pat034	352RT	FJ530907	AZT, 3TC	None	M41L, D67N, T69D, M184V, T215Y		V35K, T39D, E44D, S48T, V60I, K101R, K102KN, D121Y, K122E, I135T, S162A, K173A, Q174R, D177DE, T200A, E203D, Q207E, R211K, L228Q, V245Q	C
	Pat004	447RT	FJ530937	AZT, 3TC	None	M41L, D67N, T69D, K70R, M184V, T215Y		V35T, T39D, V60I, D121Y, K122E, I135V, K173A, D177E, T200A, Q207E, R211K, V245Q	C
Rodrigues (2010)	301_07	BR07SC301	GQ401314	3TC	None	M41L, D67N, T69D, M184V, L210W, T215C		I5V, V35T, E36A, T39D, K43R, E44D, V118I, K122E, D123S, I135T, K173T, D177E, T200A, E203D, Q207E, H208Y, R211K	C

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