<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype C
Gene RT
Mutation D67N
Rx >= 1 NRTI
(but no NNRTI)
IncludeMixtures No
References 18
Patients 62
Isolates 65
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Venturi (1999)GV-22Vent22BAF169084AZTNoneD67N, T69D, T215Y V35T, T39E, S48T, D121H, K122E, D123S, A158S, S162T, K173T, D177E, T200A, Q207EC
  Vent22W24AF169085AZT, DDCNoneD67N, T69D, K70R V35T, T39E, S48T, D121H, K122E, D123S, A158S, S162T, K173T, D177E, T200A, Q207E, T215XC
Yahi (2001)NY_M3M3AY010476DDC, 3TCNoneD67N, K70R, M184V, K219Q K20KR, V35T, E36A, T39E, E40D, K43R, T69TN, K122E, D123S, A158S, K173A, Q174QR, D177DE, T200A, E203EK, Q207E, R211K, F214L, D218DE, L228HC
Cuevas (2002)CU81CU81AF425462AZT, DDINoneD67N, K70R V35T, T39E, K64R, T69N, A98S, D121H, K122E, D123S, K173A, D177E, I178L, I195M, Q197P, T200A, Q207EC
 CU39CU39AF425420AZTNoneD67N V35T, T39E, S48T, A98S, K122E, D123N, A158S, K173A, Q174K, D177E, T200A, F214LC
Snoeck (2002)BE16aBE16aAF339010AZT, 3TCNoneD67N, K70R, M184V, K219Q V35T, T39N, S48SL, V60I, P119PL, D121DH, K122KE, D123DGNS, R125RG, I135R, N136NT, K173I, Q174K, D177E, T200A, Q207E, R211K, F214LC
Weber (2003)85H610185H-12AY140821NRTI, AZT, 3TCNoneM41L, D67N, L210W, T215Y V35T, T39E, S48T, A98S, K122E, D123N, I135T, K173T, Q174K, T200A, Q207N, R211K, V245Q, A272Q, E291D, V292I, I293VC
  610185H-48AY140823NRTI, AZT, 3TCNoneM41L, D67N, M184V, L210W, T215Y V35T, T39E, S48T, A98S, V118I, K122E, D123N, I135T, K173T, Q174K, N175Y, G196E, T200A, Q207N, R211K, V245Q, A272Q, E291D, V292I, I293VC
Montes (2004)MB_patMUK03_MUK733AJ577958DDI, AZT, D4T, 3TCNoneD67N, K219Q K20G, V35T, E36A, T39E, K103R, K122E, D123S, I135T, K173A, D177E, I178V, T200V, E203K, Q207E, R211K, F214LC
Richard (2004)RNJCR09RNJCR09AY556758AZT, 3TC, D4T, DDINoneM41L, D67N, K70R, M184V P4T, V35T, T39E, K122E, D123S, A158S, K173A, D177E, T200AC
Snoeck (2004)BE60BE60AY901312AZT, 3TCNoneD67N, K70R, M184V V35T, T39E, S48T, K122E, D123N, I135IT, A158S, K173T, D177E, T200A, Q207EK, V245Q, A272P, K277R, T286A, E291D, V292I, I293VC
Non-B Workgroup (2005)UK1518UK1518AY901342AZT, 3TCNoneD67N, K70R, M184V V35T, E36A, T39E, S48T, K122E, D123S, I135T, S162NY, K173T, D177E, T200X, Q207KC
 IL80IL80AY901353AZT, DDI, DDC, D4T, ABC, 3TCNoneM41L, D67N, M184V, L210W, T215YA98GT39E, S48T, V60I, G112X, P119PH, K122E, D123A, F124I, A158S, K173A, Q174K, D177E, T200A, Q207E, R211K, V245QC
 IL128IL128eAY901356AZT, 3TC, DDINoneM41L, D67N, K70R, T215YY181ST39E, E44D, V118VI, K122E, D123S, I135T, W153L, S163C, K173T, D177E, T200A, Q207E, K223KR, Y232*, W239RC
 UK1998UK1998AY901375ABC, AZT, 3TCNoneD67N, K70R, M184V V35T, T39K, S48T, K122E, D123E, K173T, Q174K, D177E, T200E, Q207D, R211KC
 UK2034UK2034AY901387AZT, DDINoneD67N, K70R, K219KQ V35T, E36A, T39E, S48T, K103KR, K122E, D123S, I135V, I159V, T165I, K173T, D177E, T200A, E203K, E204EK, Q207E, R211K, D218DE, W229WGC
 UK2109UK2109AY901401ABC, AZT, 3TCNoneD67N, K70R, M184V K20R, V35T, T39E, K43KR, S48T, K104R, K122E, D123N, I135T, E138A, K173I, Q174K, I195IM, T200A, E203EK, Q207E, L210LM, R211K, F214LC
 SA75_DR16SA75_DR16AY901709ABC, AZT, 3TCNoneM41L, D67N, T69D, M184V, L210W, T215FA98GV35T, T39E, E44D, S48T, E53D, V111I, V118VI, D121DG, K122E, D123S, E138EA, K173A, Q174K, D177E, G196E, T200A, E203V, Q207E, H208Y, R211K, V245Q, E248D, A272P, K277R, T286A, E291D, V292I, I293VC
 SA84_DR29SA84_DR29AY901717AZT, 3TCNoneD67N, K70R, K219QK103N, G190AV35T, E36A, T39E, S48T, V60I, K122E, D123G, V148VG, K173A, D177E, T200A, E203Q, Q207E, H221Y, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, V317AC
 IL477IL477AY901780D4T, DDINoneM41L, D67N, L210W, T215Y S48T, K65KE, V118VI, K122E, D123S, I135IT, K173T, D177E, T200A, Q207E, R211RK, V245QC
 TK3015TK3015 AZT, 3TC, DDCNoneM41L, D67N, L210W, T215Y V35M, T39D, E44D, V118I, K122E, I135L, K173A, Q174K, N175Y, D177E, V179A, E194K, G196E, T200A, I202V, Q207E, R211K, V245Q, D250E, I257V, A272S, T286A, K287X, E291D, V292I, I293V, H315FC
 TK3027TK3027 D4T, 3TCNoneD67N, M184V, T215Y V35T, T39E, S48T, K122E, D123DG, I135LM, T165I, K173A, D177E, I178V, T200A, I202V, E204K, Q207D, R211K, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, V317AC
Weber (2005)F56949F56949AY677552DDC, AZT, D4T, DDI, TDFNoneM41L, D67N, L210W, T215Y V21I, V35T, E36A, T39E, S48T, V118I, K122E, D123G, K173A, D177E, T200A, Q207E, R211K, V245Q, A272P, I274V, Q278H, K281R, T286A, E291D, V292I, I293V, K311RC
 M83284M83284AY677581D4T, DDI, ABC, AZT, 3TCNoneD67N, K70R, M184V, T215FY, K219W S48T, V60I, D121H, K122E, D123S, I142V, S162X, K173T, Q174R, D177E, I178L, T200A, Q207E, R211K, A272P, K277R, T286A, E291D, V292I, I293V, V317DNC
 M66914M66914AY677584AZT, DDI, 3TC, D4TNoneD67N, K70R, M184V, T215V, K219Q V21I, V35T, T39E, K43R, T69TS, K122E, D123S, I135V, K173T, Q174K, D177E, Q207E, V245Q, K249Q, A272P, T286A, E291D, V292I, I293VC
Marconi (2008)SW083sw083EU308093D4T, DDINoneM41L, D67N, V75VA, T215Y E44ED, S48T, K65KM, V118VI, K122E, D123G, S162Y, K173T, Q174R, D177E, T200A, E203EK, Q207E, R211K, V245QC
Pillay (2008)DR15DR15AY589875AZT, DDINoneD67N, K70R, K219E K20R, V35T, T39K, S48T, V60I, V118I, K122E, D123N, A158S, S162G, K173T, Q174A, T200A, E203EK, Q207E, R211K, F214L, V245Q, D250E, S251D, A272P, K277R, Q278E, E291D, V292I, I293V, E297KC
 DR37DR37AY589894AZT, D4T, 3TC, DDI, ABCNoneD67N, K70R, L74IV, M184V, K219KE V35M, T39D, S48T, V60VI, D123DN, K173A, Q174K, T200A, E203K, Q207E, R211K, V245Q, K249KQ, D250E, A272P, K277R, E291D, V292I, I293VC
 DR60DR60AY589912AZT, D4T, DDINoneM41L, D67N, L210W, T215Y P4T, K20R, T27S, V35T, T39E, S48T, V60I, V118I, K122E, D123S, E138A, K173T, Q174K, T200A, Q207E, R211K, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, P294PQC
 DR1602ZA.DR16AY589877ABC, AZT, 3TCNoneM41L, D67N, T69D, M184V, L210W, T215FA98GV35T, T39E, E44D, S48T, E53D, V111I, V118VI, D121DG, K122E, D123S, E138EA, K173A, Q174K, D177E, G196E, T200A, E203V, Q207E, H208Y, R211K, V245Q, E248D, A272P, K277R, T286A, E291D, V292I, I293VC
 DR7603ZA.DR76AY589922D4T, DDINoneD67N, K70R, K219Q V35T, E36A, T39E, K64KN, K122E, D123DG, K173A, Q174K, D177E, I178L, T200A, Q207KN, L210LF, R211KM, V245Q, A272P, K277R, Q278H, T286A, I293VC
 DR8103ZA.DR81AY589925D4T, DDINoneM41L, D67N, T215Y K11Q, V35T, T39E, S48T, V60I, K101Q, V118I, D121Y, K122E, D123G, I142V, S162C, K166R, K173A, D177E, T200A, Q207E, R211KC
 DR8803ZA.DR88AY589928D4T, DDINoneM41L, D67N, L210W, T215Y V35T, T39E, S48T, V60I, F77FS, G93GR, K101T, F116FL, V118I, S134I, K173A, D177E, T200A, Q207E, R211K, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, V317AC
Sylla (2008)B7173B7173_C1EF5256613TC, DDINoneD67N, M184I V35T, T39E, S48T, V60I, A98S, D121H, K122E, I135V, K173A, Q174K, P176T, I178L, T200A, Q207E, R211K, V245M, D250E, A272P, K277R, T286A, E291D, V292I, I293V, D324E, Q334H, G335D, R356K, G359T, T377M, K390R, A400T, E404DC
  B7173_C2EF5256623TC, DDINoneD67N, L74V, M184I V35T, T39E, S48T, V60I, A98S, D121H, K122E, I135V, K173A, Q174K, P176T, I178L, T200A, Q207E, R211K, V245M, D250E, A272P, K277R, T286A, E291D, V292I, I293V, D324E, Q334H, G335D, R356K, G359T, T377M, K390R, A400T, E404D, V435VIC
Deshpande (2009)Pat24814artFJ530693AZT, 3TCNoneD67N, K70R, M184V, T215F, K219EA98AGV35T, T39E, S48T, V60I, T69N, V118I, D121H, K122E, I135T, K173AT, D177E, I178M, T200A, E204K, Q207E, F214L, E224D, V245QC
 Pat23435artFJ530707AZT, 3TCNoneM41L, D67N, M184V, T215Y V35T, T39D, E44D, V60I, V90I, D121Y, K122E, S162Y, K173T, Q174K, D177E, I178L, T200A, Q207E, L210S, R211K, V245QC
 Pat21316RTFJ530728AZT, 3TCNoneM41L, D67N, K70R, M184V, T215F, K219QA98G, K101EQ, G190AK20R, E28EK, V35T, T39D, E44D, S48T, V60I, T69N, D121H, K122E, F124FV, I135T, K173A, Q174R, I178M, T200A, Q207E, R211RK, V245Q, L246WC
 Pat20920RTFJ530732D4T, 3TC, AZTNoneM41L, D67N, L74IV, M184V, L210W, T215Y, K219KNA98G, K101E, V108I, Y181CFGVK20R, K32T, V35K, T39D, E44D, S48T, V60I, V118I, D121Y, K122E, I135R, S162A, K173ST, V189I, T200A, E203V, Q207E, R211K, K223Q, T240K, V245QC
 Pat18369RTFJ530758AZT, 3TC, D4TNoneD67N, K70R, M184V, K219QV106M, G190AT27S, V35T, E36A, T39D, S48T, V60I, T69S, D121Y, K122E, I135T, E138Q, S162A, K166R, K173A, D177E, V179I, G196K, Q197R, R199RG, T200A, Q207G, R211K, F214LC
 Pat044327FJ530897AZT, 3TCNoneM41ML, D67N, K70R, V75M, M184AV, T215F, K219EG190AL12I, V35T, T39N, V60I, T69TN, D121HY, K122E, I135M, S162SN, K173A, D177E, V179I, E203EV, Q207E, L228H, V245QC
 Pat043329FJ530898AZT, 3TCNoneM41L, D67N, K70R, V75M, M184V, T215F, K219EG190AV35T, T39N, V60I, D121H, K122E, I135M, K173T, D177E, V179I, Q207E, L228H, V245QC
 Pat042336FJ530899AZT, 3TCNoneD67N, K70R, M184V, T215FI, K219EK103KN, Y181YC, G190A, K238KTT27TS, V35T, T39D, E40ED, V60I, L109I, D121H, K122E, I135T, K166R, K173T, Q174R, D177E, T200A, I202V, Q207E, R211K, L228H, V245QC
 Pat034352RTFJ530907AZT, 3TCNoneM41L, D67N, T69D, M184V, T215Y V35K, T39D, E44D, S48T, V60I, K101R, K102KN, D121Y, K122E, I135T, S162A, K173A, Q174R, D177DE, T200A, E203D, Q207E, R211K, L228Q, V245QC
 Pat004447RTFJ530937AZT, 3TCNoneM41L, D67N, T69D, K70R, M184V, T215Y V35T, T39D, V60I, D121Y, K122E, I135V, K173A, D177E, T200A, Q207E, R211K, V245QC
Rodrigues (2010)301_07BR07SC301GQ4013143TCNoneM41L, D67N, T69D, M184V, L210W, T215C I5V, V35T, E36A, T39D, K43R, E44D, V118I, K122E, D123S, I135T, K173T, D177E, T200A, E203D, Q207E, H208Y, R211KC
Van Zyl (2013)751548KC424133AZT, DDINoneD67N, K70R, T215TI, K219KE V35T, T39E, S48T, K122E, D123S, K166R, K173A, Q174K, D177E, I178M, T200A, Q207E, R211RK, V245QC
 1523326KC423987D4T, 3TCNoneD67N, T69D, K70KR, M184V K20KR, E28K, K32E, V35T, E36A, T39E, S48ST, K122E, D123GS, I135T, K173T, D177E, V179VI, T200A, Q207E, V245KC
Grossman (2014)609609KF135112ABC, DDINoneM41L, D67N, L74IV, M184V, L210W, T215Y, K219NA98GT39E, K43Q, E44D, K122E, D123S, I142V, P150T, K173A, Q174K, D177E, T200A, E203K, Q207E, H208Y, R211K, K223E, V245QC
Steegen (2014)10ZAKS05810ZAKS058KJ176340D4T, 3TCNoneD67N, K70R, M184V V35T, T39D, S48T, V60I, K122E, D123G, K173A, Q174K, D177E, I178L, T200A, Q207T, R211K, V245Q, A272S, E291D, V292I, I293V, E308X, V317AC
 09ZAKS00309ZAKS003KJ176287D4T, 3TCNoneD67N, M184V V35T, T39E, K64R, K122E, D123N, S162A, Q174H, D177E, T200A, Q207E, R211RK, F214L, P243T, V245Q, A272P, E291D, V292I, I293V, P294T, E308VC
 10ZAKS02910ZAKS029KJ176311D4T, 3TCNoneD67N, M184VA98GV35T, E36A, T39E, S48T, K66~, K122E, D123G, K173A, D177E, T200A, Q207K, R211Q, V245Q, A272P, E291D, V292I, I293VC
 12ZAKS35512ZAKS355KJ176634ABC, 3TC, D4TNoneD67N, L74V, M184V P4S, V35T, T39E, S48T, K122E, D123S, K173T, T200A, Q207D, R211K, V245Q, A272P, K275R, T286V, E291D, I293V, Q334E, G335D, R356K, M357R, R358K, G359S, A360T, E370D, A371V, T377M, K390R, E396D, A400T, E404DC
 10ZAKS03710ZAKS037KJ176319D4T, 3TCNoneD67N, M184V E6EK, V35T, E36A, T39E, S48T, K122E, D123N, I135M, K173I, Q174K, T200A, Q207E, R211K, V245Q, E248D, D250E, A272P, K277R, E291D, V292I, I293V, E308QC
 12ZAKS31912ZAKS319KJ176598D4T, 3TCNoneD67N, K70R, M184V I2V, V35T, T39E, S48T, K122E, I135L, E138A, I142T, S162C, G196E, T200A, Q207G, R211RK, P243T, V245Q, A272S, K277R, T286A, E291D, V292I, D324E, I329L, Q334N, G335D, R356K, G359T, T377R, S379C, K390R, E399D, A400T, E404D, V417I, E432D, V435AC
 12ZAKS23512ZAKS235KJ176514D4T, 3TCNoneD67N, M184V V35K, T39E, S48E, K101Q, K173A, D177E, T200A, Q207R, R211K, V245Q, E291D, V292I, I293V, I326V, Q334DC
 11ZAKS10611ZAKS106KJ176388D4T, 3TCNoneD67N, K70KR, M184V T27S, V35T, T39E, S48E, I63IV, D123E, I135T, K173A, Q174K, D177E, I178L, T200A, Q207E, R211K, F214L, V245Q, E248DN, D250E, A272P, L283I, V292I, I293V, D324E, Q334N, G335D, R356K, M357T, G359S, A376S, T377M, K390R, E399D, A400T, T403A, E404DC
 12ZAKS19512ZAKS195KJ176476D4T, 3TCNoneD67N, M184V V35K, T39E, S48E, K101Q, I135IV, K173A, D177E, T200A, Q207R, R211K, V245Q, K277KR, E291D, V292I, I293V, I326V, Q334D, I341V, R356K, M357K, G359S, T377M, K390R, A400T, T403M, E404DC
 10ZAKS05210ZAKS052KJ176334D4T, 3TCNoneD67N, K70KR, M184V V35T, T39D, S48T, V60I, K122E, D123G, K173A, Q174K, D177E, I178L, T200A, Q207T, R211K, V245Q, A272S, E291D, V292I, I293VC
 12ZAKS26112ZAKS261KJ176540TDF, D4T, 3TCNoneM41L, D67N, T69D, K70R, V75M, M184V, T215FK103N, V106MV35T, E36EA, T39AE, S48T, K49R, V60I, K122E, I135T, T139K, S162SN, K173T, Q174K, D177E, I178M, T200A, E203K, Q207E, H208Y, R211K, W212M, F214L, K223E, P243S, V245K, K249Q, A272P, E291D, I293V, P313PS, V317VA, S322A, Q334N, G335D, A355S, R356K, R358K, G359N, A376S, T377L, K390R, E399D, A400I, T403A, E404DC
 11ZAKS11711ZAKS117KJ176399D4T, 3TCNoneD67N, M184V T27S, V35T, T39E, S48E, D123E, I135T, S162Y, K173A, Q174K, D177E, I178L, T200A, Q207E, F214L, V245Q, E248N, D250E, A272P, L283I, V292I, I293V, Q334N, G335D, R356K, M357T, G359S, A376S, T377M, K390R, E399D, A400T, T403A, E404DC
 12ZAKS20412ZAKS204KJ176484ABC, 3TCNoneD67N, K70R, M184V, K219EY181CE6K, V35T, E36A, T39E, S48T, V60I, K122E, S162C, K173A, D177E, T200A, Q207N, R211K, H221Y, V245Q, A272P, Q278H, K281R, E291D, V292I, S322T, Q334D, G335DC
 12ZAKS28212ZAKS282KJ176561D4T, 3TCNoneD67N, K70R, M184V, K219EQK103NV35T, E36A, T39E, K43Q, V60I, K102KQ, K122E, D123G, K173T, Q174K, D177E, G196E, T200A, E203K, Q207E, V245E, A272P, E291D, V292I, I293V, D324E, Q334N, G335D, R356K, M357R, G359T, A360T, T377Q, K390R, A400I, E404DC
 11ZAKS15711ZAKS157KJ176439D4T, 3TCNoneD67N, M184VK103NP4T, K20R, V35T, T39E, S48T, K122E, D123N, A158S, K173A, Q174K, D177E, G196K, T200A, Q207A, R211K, V245M, D250E, A272P, E291D, I293V, I326V, G335DC
 10ZAKS03810ZAKS038KJ176320D4T, 3TCNoneM41L, D67N, K70R, L74I, M184V, K219Q V35T, T39E, S48T, E53D, K122E, I135T, S162A, K173T, Q174K, V179I, T200A, Q207E, R211KT, F214L, P243PT, V245Q, A272P, K275R, Q278H, K281R, T286A, E291D, V292I, I293V, P294TC