<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype C
Gene RT
Mutation K65R
Rx >= 1 NRTI
(but no NNRTI)
IncludeMixtures No
References 10
Patients 42
Isolates 45
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Johnston (2003)TC-71TC-71 DDI, AZT, 3TCNoneA62V, K65R, F116Y, Q151M, M184V V8I, V35T, T39E, V60I, S68R, W88S, K101Q, K122E, D123S, I135T, E138A, K173T, Q174K, V179I, T200A, Q207E, R211K, F214L, V245Q, E248DC
Vergne (2003)VL98SN53HALD98SN53AJ583735AZT, DDINoneK65R V35T, E36A, T39E, S48T, K122E, D123N, K173A, D177E, T200A, Q207N, V245Q, D250G, A272P, K277R, T286A, E291D, V292I, I293V, I329L, G335D, R356K, G359T, A376T, T377M, T386A, A400T, T403M, E404D, E432D, D443NC
Non-B Workgroup (2005)SA81_DR26SA81_DR26AY901714D4T, DDINoneA62V, K65R, V75T I2V, V35T, T39E, S48T, E53D, S68G, V118I, K122E, D123S, I135T, E138A, E169ED, K173AT, Q174K, I178M, T200A, Q207E, R211RK, F214L, K219G, V245VE, D250E, K263KN, A272P, K277R, L283I, T286A, E291D, V292I, I293V, V317AC
 TK1021TK1021 AZT, 3TC, D4T, ABC, DDINoneK65R, M184V V35T, E36A, T39E, S48T, V60I, S68G, V90I, K122E, D123S, I135V, E138A, K166R, K173T, E194E*, T200A, Q207D, R211K, V245Q, E248D, A272P, K275KR, K277R, T286A, E291D, V292I, I293VC
Rey (2006)H3117DR_H3117 TDF, AZT, 3TCNoneA62AV, K65R, K70KT, Y115YF, M184MV V35L, E36N, I37F, T39E, S48T, S68R, V118I, T139A, K166R, K173T, D177E, T200E, Q207E, R211K, F214L, L228LR, V245TC
Pillay (2008)DR59DR59AY589911D4T, DDINoneA62V, K65R, V75I, F77L, F116Y, Q151M T39E, S68G, A98S, K122A, S162SCNY, S163ST, K173A, Q174K, D177E, I178L, T200A, Q207D, R211K, V245Q, A272P, Q278H, I293V, S322A, Q334XC
 DR2602ZA.DR26AY589883D4T, DDINoneA62V, K65R, V75T I2V, V35T, T39E, S48T, E53D, S68G, V118I, K122E, D123S, I135T, E138A, E169ED, K173AT, Q174K, I178M, T200A, Q207E, R211RK, F214L, K219G, V245VE, D250E, K263KN, A272P, K277R, L283I, T286A, E291D, V292I, I293V, V317AC
Van Zyl (2013)92111.ZA.WC151KC423490AZT, 3TCNoneK65R, V75VIM, Y115FK103N, V106MV35T, E36A, T39E, S48T, V60I, K122E, D123S, K173A, Q174K, D177E, I178IM, T200A, Q207E, R211K, V245Q, D250DEC
 401911.ZA.GT1642KC423436AZT, 3TCNoneK65RK103N, Y181C, G190AP14A, K20R, V35T, E36A, T39E, E40D, S68N, W88C, K101Q, K122E, D123N, I135T, I142V, T200A, I202IV, Q207A, R211K, F214L, H221Y, V245L, D250EC
 406911.ZA.GT2008KC423750AZT, 3TCNoneK65R, M184V, K219EL100I, K103NV35T, E36A, T39E, V60I, S68G, K122E, D123S, T139V, K173A, D177E, V179VI, T200A, E203K, Q207A, R211K, D218E, V245QC
 73610.ZA.WC092KC423161ABC, 3TCNoneK65R, V75M, M184V V35T, E36A, T39E, S48T, S68N, K122E, D123S, S162C, K173I, Q174K, T200A, E203EA, Q207E, R211K, F214LC
 23511.ZA.GT1949KC423729TDF, 3TCNoneA62AV, K65R, M184VK101E, V106M, V108VI, F227LK22R, E28K, V35T, E36A, T39E, E40D, S68N, W88C, A98S, L109LI, K122E, D123N, K173A, D177G, T200A, Q207EK, R211K, F214FL, D218E, V245EC
Acharya (2014)DGP127DGP127KJ185297AZT, 3TCNoneK65R, M184VK103N, Y181CS3R, V35T, T39D, V60I, D121Y, K122E, D123E, F124L, I135T, S162H, K173A, D177E, G196K, T200A, Q207E, R211K, V245Q, D250E, A272P, K277R, T286A, E291D, V292VI, P294TC
 DGP054DGP054KJ185224TDF, 3TCNoneK65R V35T, T39D, V60I, D121H, K122E, I135K, S162A, K173E, D177E, I178L, T200A, E204K, Q207D, R211K, V245Q, A272P, K277R, E291D, V292I, I293V, E297AC
Steegen (2014)11ZAKS14411ZAKS144KJ176426ABC, 3TCNoneK65RK103N, Y181CP4H, V35T, E36A, T39D, K122E, D123N, I135T, K173A, Q174K, D177E, T200A, Q207E, R211K, V245Q, A272AS, K277R, T286A, E291D, V292I, I293V, E297A, E312EQC
Neogi (2016)415513.ZA.GT2809KT593153AZT, 3TCNoneK65RV106M, V179D, Y181CK20KR, E28EK, E29EK, V35T, E36A, T39E, E40ED, S48T, V60I, K122E, D123G, T165I, K173T, D177E, I178L, T200A, Q207E, R211K, V245QC
 414213.ZA.GT2704KT593070TDF, DDINoneK65R V35T, E36A, T39E, S48T, V60I, K122E, D123G, K173A, Q174K, D177E, T200A, Q207E, R211K, F214L, V245QC
 107013.ZA.EC839KT592931TDF, AZT, 3TCNoneK65R, M184VL100I, V179DK20R, V35T, T39E, S48T, K103R, K122E, D123S, K173A, D177G, T200A, Q207A, V245QC
 422513.ZA.GT2765KT593122AZT, 3TCNoneK65RK103N, Y181CV35T, T39N, S48T, V60I, T69N, K122E, D123S, K173A, Q174K, D177E, Q207R, R211S, V245QC
 712113.ZA.EC566KT592763D4T, 3TCNoneA62V, K65R, M184VY188LV35T, T39E, S48T, S68N, K122E, D123S, I135T, E138D, S162C, K173A, Q174K, D177E, I178L, T200A, Q207A, R211K, V245QC
 556413.ZA.EC686KT592842AZT, 3TCNoneK65R, L74LI, M184VL100I, K103N, V108IV35T, T39E, S48T, V60I, S68SN, K122E, D123G, E169A, K173A, D177E, T200A, Q207E, R211K, V245QC
 226813.ZA.GT2690KT593058AZT, 3TCNoneK65R, K70TK101E, Y181C, G190AV35T, T39E, S48T, V60I, S68G, D121Y, K122E, K173T, Q174K, D177E, I178L, T200A, Q207D, R211K, L228R, V245QC
Posada Cespedes (2017)158815.ZA.GT4457 AZT, 3TCNoneK65R, D67N, K219EK101E, V106M, Y181C, G190AE6K, V8I, K20R, V35T, E36A, T39E, S48T, V60I, S68G, K122E, D123S, A158S, T165I, K173A, Q174K, D177E, T200A, I202IV, Q207E, R211K, V245QC
 245715.ZA.GT4380 AZT, 3TCNoneK65R, M184VA98G, K101H, V108I, Y181C, G190AV35T, T39E, E40Q, K46Q, S48T, V60I, S68N, K102Q, K103R, K122E, D123G, T139R, K173A, Q174R, D177E, G196E, T200A, Q207E, R211K, F214L, V245QC
 716314.ZA.GT3284KX544178AZT, 3TCNoneA62V, K65R, M184VV106M, V179VD, Y181YC, G190AV35T, T39A, S48T, E53D, S68N, K122E, D123N, K173T, T200A, Q207E, R211K, F214L, L228Q, V245QC
 575515.ZA.EC1670 AZT, 3TCNoneK65RK101E, G190SP4S, V35T, T39E, S48T, S68G, K122E, D123N, E138A, I142V, S162C, K173A, D177E, T200A, E204Q, Q207D, R211K, V245QC
 285312.ZA.GT2408KX542233D4T, 3TCNoneK65R, Y115YFK103N, V106MK20R, V35K, T39E, K102KR, K122E, D123S, S162A, K173T, Q174K, D177E, I178L, T200A, Q207D, R211K, V245QC
 57614.ZA.EC1203KX543822TDF, 3TCNoneK65R, M184V, K219EK103KN, G190AV35T, E36A, T39E, S48T, K64R, S68K, K102N, K122E, D123S, S162C, K173KAET, Q174QK, D177E, I178IM, T200A, Q207D, R211K, F214L, V245Q, E248DC
 414713.ZA.GT3084KX543348D4T, 3TCNoneK65R, M184VV106M, V179DK20R, V35T, T39E, S48T, S68K, K103R, K122E, D123G, I135T, E138A, K173N, Q174K, N175Y, Q197QL, T200A, I202V, Q207E, F214L, V245L, E248DC
 477514.ZA.GT3867 AZT, 3TCNoneK65RA98G, V108VI, Y181C, G190AV35T, T39E, S48T, S68SN, K101Q, K122E, D123G, T165TI, K173A, D177E, T200A, E203D, R211K, H221HY, V245QC
 219415.ZA.GT4377 TDF, 3TCNoneK65R, Y115YFK103N, V106ME29E*KQ, V35T, E36A, T39E, S48T, K122E, I142V, E169D, K173A, Q174K, D177E, G196E, T200A, E203K, Q207EC
 313606.ZA.GT015KX539561AZT, 3TCNoneK65R, K70R, V75I, F77L, F116Y, Q151MK103N, V106MV21I, K32I, V35T, T39K, S48T, K64KQ, S68G, V118I, K122E, D123S, T139A, I142T, T165I, Q182H, G196E, T200A, Q207E, F214L, L228Q, A272P, Q278H, T286A, E291D, V292I, I293VC
 249314.ZA.GT3262KX544160AZT, 3TC, DDINoneK65R, M184VK103N, V108I, Y181CV35T, T39E, K122E, D123N, T139K, S162C, K173A, Q174K, D177E, I178M, T200A, Q207E, R211K, P243H, V245E, E248DC
 714113.ZA.GT2899KX543210AZT, 3TCNoneA62V, K65R, M184IG190QV35T, E36A, T39D, T165I, K173A, Q174K, D177E, V179I, T200A, Q207E, R211KC
 500215.ZA.GT4108 ABC, 3TCNoneK65R, M184VV106M, V179D, Y181C, F227FLK20R, V35K, T39D, S48T, V60VI, S68SG, K102KR, K122KE, D123DN, T165I, K173E, Q174K, G196KT, T200A, Q207E, F214FL, V245QC
 244614.ZA.GT3598 D4T, 3TCNoneK65R, Y115F, M184VV106M, V179D, F227LT27S, V35T, E36A, T39E, S48T, K122E, K173KE, D177E, Q197K, T200A, Q207E, R211K, V245QC
 415313.ZA.GT2667KX543009AZT, 3TCNoneA62V, K65R, M184VA98G, V106M, Y181C, G190AV35T, T39E, S48T, S68N, K122E, D123S, T139S, K173T, D177E, I178V, T200A, I202V, E204K, Q207E, R211K, F214L, V245Q, D250EC
 53714.ZA.EC1202KX543821ABC, 3TCNoneK65R, M184V V8I, K11Q, E28K, K32E, V35T, E36A, T39E, S68K, D121Y, K122E, D123G, E138A, S162C, K173A, Q174K, D177E, V179I, T200A, Q207E, R211K, V245QC
 494915.ZA.GT4019 TDF, 3TCNoneA62V, K65R, Y115F, M184VK103N, V106MV35T, T39E, S48T, K122E, D123S, I135T, S162C, K173T, Q174K, D177E, I178L, T200A, Q207E, R211K, V245Q, D250EC
  15.ZA.GT4056 TDF, 3TCNoneA62V, K65R, Y115YF, M184VK103N, V106MV35T, T39E, S48T, K122E, D123S, I135T, S162C, K173T, Q174K, D177E, I178L, T200A, Q207E, R211K, V245Q, D250EC
 226813.ZA.GT3052KX543326AZT, 3TCNoneM41L, K65R, K70N, K219KQK101E, Y181C, G190AV35T, E36EK, T39E, S48T, V60I, S68G, T69I, D121Y, K122E, K126KR, K173T, Q174K, D177E, I178L, T200A, Q207D, R211K, L228R, V245QC
 429514.ZA.GT3268KX544165TDF, 3TCNoneK65R, K70T, Y115F, M184VA98G, K103N, V106MK20R, K32E, V35T, T39K, V60I, S68G, T69I, W88CS, D121H, K122E, I135K, K173T, Q174KR, D177E, I178L, T200A, Q207E, R211K, F214FL, L228Q, V245Q, E248DC
 229514.ZA.GT3536KX544379AZT, 3TCNoneK65RV108I, Y181CE6EK, V35T, T39A, K46Q, S48T, S68G, K122E, D123DG, S162SC, K173A, D177E, T200A, Q207H, R211K, H221Y, V245QC
  14.ZA.GT3888 AZT, 3TCNoneK65RV108I, Y181CE6EK, V35T, T39A, K46Q, S48T, S68G, K122E, S162C, K173A, D177E, T200A, Q207H, R211K, H221Y, V245QC
 307611.ZA.GT1868KX541354ABC, 3TC, DDINoneK65R V35T, E36A, T39E, S48T, K122E, D123S, S162A, K173T, D177N, T200E, Q207K, R211K, D250EC