<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype C
Gene RT
Mutation K65R
Rx >= 1 NRTI
(but no NNRTI)
IncludeMixtures No
References 7
Patients 19
Isolates 19
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Johnston (2003)TC-71TC-71 DDI, AZT, 3TCNoneA62V, K65R, F116Y, Q151M, M184V V8I, V35T, T39E, V60I, S68R, W88S, K101Q, K122E, D123S, I135T, E138A, K173T, Q174K, V179I, T200A, Q207E, R211K, F214L, V245Q, E248DC
Non-B Workgroup (2005)SA81_DR26SA81_DR26AY901714D4T, DDINoneA62V, K65R, V75T I2V, V35T, T39E, S48T, E53D, S68G, V118I, K122E, D123S, I135T, E138A, E169ED, K173AT, Q174K, I178M, T200A, Q207E, R211RK, F214L, K219G, V245VE, D250E, K263KN, A272P, K277R, L283I, T286A, E291D, V292I, I293V, V317AC
 TK1021TK1021 AZT, 3TC, D4T, ABC, DDINoneK65R, M184V V35T, E36A, T39E, S48T, V60I, S68G, V90I, K122E, D123S, I135V, E138A, K166R, K173T, E194X, T200A, Q207D, R211K, V245Q, E248D, A272P, K275KR, K277R, T286A, E291D, V292I, I293VC
Rey (2006)H3117DR_H3117 TDF, AZT, 3TCNoneA62AV, K65R, K70KT, Y115YF, M184MV V35L, E36N, I37F, T39E, S48T, S68R, V118I, T139A, K166R, K173T, D177E, T200E, Q207E, R211K, F214L, L228LR, V245TC
Pillay (2008)DR59DR59AY589911D4T, DDINoneA62V, K65R, V75I, F77L, F116Y, Q151M T39E, S68G, A98S, K122A, S162X, S163ST, K173A, Q174K, D177E, I178L, T200A, Q207D, R211K, V245Q, A272P, Q278H, I293V, S322A, Q334XC
 DR2602ZA.DR26AY589883D4T, DDINoneA62V, K65R, V75T I2V, V35T, T39E, S48T, E53D, S68G, V118I, K122E, D123S, I135T, E138A, E169ED, K173AT, Q174K, I178M, T200A, Q207E, R211RK, F214L, K219G, V245VE, D250E, K263KN, A272P, K277R, L283I, T286A, E291D, V292I, I293V, V317AC
Van Zyl (2013)92111.ZA.WC151KC423490AZT, 3TCNoneK65R, V75VIM, Y115FK103N, V106MV35T, E36A, T39E, S48T, V60I, K122E, D123S, K173A, Q174K, D177E, I178IM, T200A, Q207E, R211K, V245Q, D250DEC
 401911.ZA.GT1642KC423436AZT, 3TCNoneK65RK103N, Y181C, G190AP14A, K20R, V35T, E36A, T39E, E40D, S68N, W88C, K101Q, K122E, D123N, I135T, I142V, T200A, I202IV, Q207A, R211K, F214L, H221Y, V245L, D250EC
 406911.ZA.GT2008KC423750AZT, 3TCNoneK65R, M184V, K219EL100I, K103NV35T, E36A, T39E, V60I, S68G, K122E, D123S, T139V, K173A, D177E, V179VI, T200A, E203K, Q207A, R211K, D218E, V245QC
 73610.ZA.WC092KC423161ABC, 3TCNoneK65R, V75M, M184V V35T, E36A, T39E, S48T, S68N, K122E, D123S, S162C, K173I, Q174K, T200A, E203EA, Q207E, R211K, F214LC
 23511.ZA.GT1949KC423729TDF, 3TCNoneA62AV, K65R, M184VK101E, V106M, V108VI, F227LK22R, E28K, V35T, E36A, T39E, E40D, S68N, W88C, A98S, L109LI, K122E, D123N, K173A, D177G, T200A, Q207EK, R211K, F214FL, D218E, V245EC
Steegen (2014)11ZAKS14411ZAKS144KJ176426ABC, 3TCNoneK65RK103N, Y181CP4H, V35T, E36A, T39D, K122E, D123N, I135T, K173A, Q174K, D177E, T200A, Q207E, R211K, V245Q, A272AS, K277R, T286A, E291D, V292I, I293V, E297A, E312EQC
Neogi (2016)415513.ZA.GT2809KT593153AZT, 3TCNoneK65RV106M, V179D, Y181CK20KR, E28EK, E29EK, V35T, E36A, T39E, E40ED, S48T, V60I, K122E, D123G, T165I, K173T, D177E, I178L, T200A, Q207E, R211K, V245QC
 414213.ZA.GT2704KT593070TDF, DDINoneK65R V35T, E36A, T39E, S48T, V60I, K122E, D123G, K173A, Q174K, D177E, T200A, Q207E, R211K, F214L, V245QC
 107013.ZA.EC839KT592931TDF, AZT, 3TCNoneK65R, M184VL100I, V179DK20R, V35T, T39E, S48T, K103R, K122E, D123S, K173A, D177G, T200A, Q207A, V245QC
 422513.ZA.GT2765KT593122AZT, 3TCNoneK65RK103N, Y181CV35T, T39N, S48T, V60I, T69N, K122E, D123S, K173A, Q174K, D177E, Q207R, R211S, V245QC
 712113.ZA.EC566KT592763D4T, 3TCNoneA62V, K65R, M184VY188LV35T, T39E, S48T, S68N, K122E, D123S, I135T, E138D, S162C, K173A, Q174K, D177E, I178L, T200A, Q207A, R211K, V245QC
 556413.ZA.EC686KT592842AZT, 3TCNoneK65R, L74LI, M184VL100I, K103N, V108IV35T, T39E, S48T, V60I, S68SN, K122E, D123G, E169A, K173A, D177E, T200A, Q207E, R211K, V245QC
 226813.ZA.GT2690KT593058AZT, 3TCNoneK65R, K70TK101E, Y181C, G190AV35T, T39E, S48T, V60I, S68G, D121Y, K122E, K173T, Q174K, D177E, I178L, T200A, Q207D, R211K, L228R, V245QC