<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype C
Gene RT
Mutation E44D
Rx >= 1 NRTI
(but no NNRTI)
IncludeMixtures No
References 11
Patients 26
Isolates 27
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Weidle (2001)PW_UG454PW_UG454aAY901264AZT, 3TCNoneM184V V35T, E36A, T39E, E44D, S48T, K122E, D123S, I135IMT, A158S, E169ED, K173T, Q174K, D177E, T200A, R211K, V245Q, A272P, K277R, L283LI, E291D, V292I, I293V, G335D, R356K, G359T, T377LR, K390RC
Non-B Workgroup (2005)IL81IL81AY901354AZT, 3TC, ABC, DDINoneM41L, D67DN, M184V, L210W, T215Y T39DE, K43KQ, E44D, A98S, V118VI, K122E, K173T, D177E, G196E, T200A, Q207E, R211K, V245QC
 IL128IL128d AZT, 3TC, DDINoneM41L, D67DN, K70KR, M184MV, T215NY T39E, E44D, K101KI, K122E, D123S, I135T, K173AT, D177E, T200A, Q207E, D237DE, V245QC
  IL128eAY901356AZT, 3TC, DDINoneM41L, D67N, K70R, T215YY181ST39E, E44D, V118VI, K122E, D123S, I135T, W153L, S163C, K173T, D177E, T200A, Q207E, K223KR, Y232*, W239RC
 SA75_DR16SA75_DR16AY901709ABC, AZT, 3TCNoneM41L, D67N, T69D, M184V, L210W, T215FA98GV35T, T39E, E44D, S48T, E53D, V111I, V118VI, D121DG, K122E, D123S, E138EA, K173A, Q174K, D177E, G196E, T200A, E203V, Q207E, H208Y, R211K, V245Q, E248D, A272P, K277R, T286A, E291D, V292I, I293VC
 IL86IL86AY901741AZT, D4TNone  E44D, K49KR, A98S, K122E, D123S, I135T, A158S, K173A, D177EG, T200TA, Q207E, R211K, V245QC
 TK3015TK3015 AZT, 3TC, DDCNoneM41L, D67N, L210W, T215Y V35M, T39D, E44D, V118I, K122E, I135L, K173A, Q174K, N175Y, D177E, V179A, E194K, G196E, T200A, I202V, Q207E, R211K, V245Q, D250E, I257V, A272S, T286A, K287KN, E291D, V292I, I293V, H315FC
Pillay (2008)DR1602ZA.DR16AY589877ABC, AZT, 3TCNoneM41L, D67N, T69D, M184V, L210W, T215FA98GV35T, T39E, E44D, S48T, E53D, V111I, V118VI, D121DG, K122E, D123S, E138EA, K173A, Q174K, D177E, G196E, T200A, E203V, Q207E, H208Y, R211K, V245Q, E248D, A272P, K277R, T286A, E291D, V292I, I293VC
Deshpande (2009)Pat23435artFJ530707AZT, 3TCNoneM41L, D67N, M184V, T215Y V35T, T39D, E44D, V60I, V90I, D121Y, K122E, S162Y, K173T, Q174K, D177E, I178L, T200A, Q207E, L210S, R211K, V245QC
 Pat21316RTFJ530728AZT, 3TCNoneM41L, D67N, K70R, M184V, T215F, K219QA98G, K101EQ, G190AK20R, E28EK, V35T, T39D, E44D, S48T, V60I, T69N, D121H, K122E, F124FV, I135T, K173A, Q174R, I178M, T200A, Q207E, R211RK, V245Q, L246WC
 Pat20920RTFJ530732D4T, 3TC, AZTNoneM41L, D67N, L74IV, M184V, L210W, T215Y, K219KNA98G, K101E, V108I, Y181CFGVK20R, K32T, V35K, T39D, E44D, S48T, V60I, V118I, D121Y, K122E, I135R, S162A, K173ST, V189I, T200A, E203V, Q207E, R211K, K223Q, T240K, V245QC
 Pat034352RTFJ530907AZT, 3TCNoneM41L, D67N, T69D, M184V, T215Y V35K, T39D, E44D, S48T, V60I, K101R, K102KN, D121Y, K122E, I135T, S162A, K173A, Q174R, D177DE, T200A, E203D, Q207E, R211K, L228Q, V245QC
Rodrigues (2010)301_07BR07SC301GQ4013143TCNoneM41L, D67N, T69D, M184V, L210W, T215C I5V, V35T, E36A, T39D, K43R, E44D, V118I, K122E, D123S, I135T, K173T, D177E, T200A, E203D, Q207E, H208Y, R211KC
Sigaloff (2011)HIV100072HIV100072JN1322163TCNoneM41L, L74I, M184V, L210W, T215YK103N, Y318FV35T, E36A, T39D, E44D, S48T, V90I, K102R, K122E, D123N, I135T, E138G, S162Y, K173A, Q174R, T200A, Q207E, R211RK, V245Q, E248D, A272P, L279M, T286A, E291D, V292I, I293VC
Van Zyl (2013)16012.ZA.NL032KC423962ABC, 3TCNoneM184V T27S, V35T, E36S, T39E, E44D, I47X, K49R, N57X, V60I, I63X, K122E, D123E, F171Y, K173A, Q174N, D177E, I178V, T200A, I202V, Q207E, R211K, F214L, V245Q, E248VC
Acharya (2014)DGP175DGP175KJ185345TDF, 3TCNoneM41L, D67N, K70R, L74I, M184V, T215Y, K219QA98G, K103NV35T, T39D, E44D, S48T, V60I, K101R, V118I, D121Y, K122E, S162A, K173T, Q174K, D177E, I178M, T200A, E204A, Q207D, R211K, V245Q, A272P, K277R, T286A, E291D, V292IC
Grossman (2014)609609KF135112ABC, DDINoneM41L, D67N, L74IV, M184V, L210W, T215Y, K219NA98GT39E, K43Q, E44D, K122E, D123S, I142V, P150T, K173A, Q174K, D177E, T200A, E203K, Q207E, H208Y, R211K, K223E, V245QC
 512512KF1350923TC, DDINone  T39E, E44D, A98S, K122E, D123S, R125RS, I135M, K173A, D177E, Q207E, R211K, V245QC
 943943KF135164ABC, DDINoneT215Y T39E, E44D, K49R, K64R, A98S, K122E, D123S, A158S, K173A, Q174K, D177E, T200A, Q207E, V245QC
 429429 D4T, 3TCNone  T39D, E44D, A98S, K122E, D123G, T165TI, K173A, D177E, T200A, Q207E, L210LS, V245QC
Neogi (2016)558113.ZA.EC755KT592886AZT, 3TCNoneM41L, D67G, V75M, M184V, L210W, T215YK101N, V108I, Y181C, G190A, F227LE28A, K32E, V35T, T39R, K43E, E44D, S48T, W88C, K122E, D123S, S162C, K173A, D177E, T200A, E203K, Q207E, R211RK, H221Y, K223E, L228R, V245QC
 86913.ZA.WC351KT593537TDF, AZT, 3TCNoneM41L, A62V, V75I, M184V, T215YA98G, V106M, Y188F, F227LI31L, V35I, T39E, K43R, E44D, S48T, L109I, V118I, D121HY, K122E, I135L, I142IV, S162A, K173T, D177E, V189I, T200A, I202V, Q207E, L210T, R211K, D218E, H221Y, V245QC
 548313.ZA.EC490KT592708TDF, 3TCNoneM41L, D67N, M184V, T215YK103N, G190AV35T, T39E, E44D, K101Q, K173A, Q174K, D177E, T200A, Q207E, L210S, R211K, V245KC
Posada Cespedes (2017)14712.ZA.NC003KX542397AZT, DDINoneM41L, D67N, K70R, V75M, T215Y E6K, K20R, V35T, T39E, E44D, S48T, V60I, K103R, V111VI, V118I, K122E, I135T, T139TA, K173V, Q174K, N175Y, D177E, V179T, G196E, T200A, Q207D, H208Y, R211K, D218E, V245QC
 485315.ZA.GT3954 AZT, 3TCNoneM41L, D67N, V75M, F77FL, M184V, L210W, T215YA98G, P225HK20R, T27S, E28K, K32E, A33AG, V35T, T39E, K43KR, E44D, I94L, V118VI, K122E, D123DG, I135L, K173A, Q174R, D177E, V179VI, T200A, E203D, Q207E, R211K, V245QC
 57314.ZA.EC1425KX544019AZT, 3TCNoneM41L, D67N, L210W, T215Y, K219KR K20R, V35T, T39E, E44D, V111VIM, V118I, K122E, D123S, I142T, K173A, D177E, I178L, T200A, K201R, E203D, E204K, Q207D, H208Y, R211K, W212M, D218E, H221Y, V245Q, E248TC
 100114.ZA.WC478KX544738ABC, 3TCNoneM184MV, T215TI, K219KNY181CV35T, E36A, T39E, E44D, S48T, T69TN, K122E, D123N, I135T, E169K, K173E, D177E, T200A, I202V, Q207EGKR, R211Q, V245QC