<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype C
Gene RT
Mutation M41L
Rx >= 1 NRTI
(but no NNRTI)
IncludeMixtures No
References 16
Patients 69
Isolates 74
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Yahi (2001)NY_M4M4AY010469AZT, 3TCNoneM41L, M184MV V35T, E36A, T39E, K43R, S48T, E53D, K122E, D123S, I135T, I142V, K173AS, D177E, T200A, Q207E, R211K, T215X, L228H, K238RC
 NY_M6M6AY010480D4T, 3TCNoneM41L, M184V, T215Y V35T, E36A, T39D, S48T, K122E, A158S, K173T, T200A, Q207EC
Kantor (2002)TCDD-27TCDD-27AY090853AZT, 3TCNoneM41L, D67DN, K70KR, M184V, T215YA98AGV35T, E36A, T39D, S48ST, V60I, K122E, D123N, I135T, K173A, Q174K, D177E, T200A, L205LF, Q207E, R211KC
 TCDD-35TCDD-35_1AY090860DDC, AZT, 3TCNoneM41L, K70KR, M184V, T215Y V35T, E36A, T39E, S48T, E53D, V60I, K122E, D123S, I135V, S162C, K166R, I167IV, K173A, Q174K, D177E, I178L, T200A, Q207E, R211K, L228HC
Weber (2003)85H610185H-0AY140820NRTINoneM41L, L210W, T215Y V35T, T39E, S48T, A98S, K122E, D123N, I135T, K173T, Q174K, T200A, Q207N, R211K, V245Q, A272Q, E291D, V292I, I293VC
  610185H-12AY140821NRTI, AZT, 3TCNoneM41L, D67N, L210W, T215Y V35T, T39E, S48T, A98S, K122E, D123N, I135T, K173T, Q174K, T200A, Q207N, R211K, V245Q, A272Q, E291D, V292I, I293VC
  610185H-48AY140823NRTI, AZT, 3TCNoneM41L, D67N, M184V, L210W, T215Y V35T, T39E, S48T, A98S, V118I, K122E, D123N, I135T, K173T, Q174K, N175Y, G196E, T200A, Q207N, R211K, V245Q, A272Q, E291D, V292I, I293VC
Montes (2004)MB_patVID99_VID711AJ578177D4T, DDI, AZTNoneM41L V35T, E36A, T39E, S48T, K122E, D123E, K173V, D177E, T200A, Q207E, R211K, V245QC
Richard (2004)RNJCR09RNJCR09AY556758AZT, 3TC, D4T, DDINoneM41L, D67N, K70R, M184V P4T, V35T, T39E, K122E, D123S, A158S, K173A, D177E, T200AC
Non-B Workgroup (2005)UK1154UK1154AY901331AZT, DDI, D4T, 3TCNoneM41L, M184V, T215Y V8I, V35T, T39E, K122E, I135T, A158S, K173A, Q174R, D177E, I178M, T200A, Q207E, R211QC
 IL80IL80AY901353AZT, DDI, DDC, D4T, ABC, 3TCNoneM41L, D67N, M184V, L210W, T215YA98GT39E, S48T, V60I, G112X, P119PH, K122E, D123A, F124I, A158S, K173A, Q174K, D177E, T200A, Q207E, R211K, V245QC
 IL81IL81AY901354AZT, 3TC, ABC, DDINoneM41L, D67DN, M184V, L210W, T215Y T39DE, K43KQ, E44D, A98S, V118VI, K122E, K173T, D177E, G196E, T200A, Q207E, R211K, V245QC
 IL128IL128b AZT, 3TC, DDINoneM41L, M184MV, T215YK238KTT39E, K122E, D123S, I135T, K173T, D177E, T200A, Q207E, V245QC
  IL128c AZT, 3TC, DDINoneM41L, M184MV, T215TN T39E, K122E, D123S, I135T, A158AS, E169EA, K173AT, Q174QK, D177E, T200A, Q207E, V245AC
  IL128d AZT, 3TC, DDINoneM41L, D67DN, K70KR, M184MV, T215NY T39E, E44D, K101KI, K122E, D123S, I135T, K173AT, D177E, T200A, Q207E, D237DE, V245QC
  IL128eAY901356AZT, 3TC, DDINoneM41L, D67N, K70R, T215YY181ST39E, E44D, V118VI, K122E, D123S, I135T, W153L, S163C, K173T, D177E, T200A, Q207E, K223KR, Y232*, W239RC
 SA75_DR16SA75_DR16AY901709ABC, AZT, 3TCNoneM41L, D67N, T69D, M184V, L210W, T215FA98GV35T, T39E, E44D, S48T, E53D, V111I, V118VI, D121DG, K122E, D123S, E138EA, K173A, Q174K, D177E, G196E, T200A, E203V, Q207E, H208Y, R211K, V245Q, E248D, A272P, K277R, T286A, E291D, V292I, I293VC
 IL287IL287AY901765AZT, 3TC, ABC, DDINoneM41L, T215Y T39E, K102Q, K122E, D123S, I135IT, A158S, S162A, K173AV, Q174K, D177E, T200A, Q207E, R211K, V245QC
 IL433IL433bAY901779DDC, AZTNoneM41L, L210W, T215Y T39E, V118VI, K122E, D123E, A158S, K173A, Q174K, D177E, I178M, T200A, Q207E, L228LR, V245QC
 IL477IL477AY901780D4T, DDINoneM41L, D67N, L210W, T215Y S48T, K65KE, V118VI, K122E, D123S, I135IT, K173T, D177E, T200A, Q207E, R211RK, V245QC
 IL719IL719AY901785AZT, 3TCNoneM41L, T215Y T39E, K49R, I50V, K122E, D123G, A158S, K173A, D177E, G196K, T200A, Q207E, V245QC
 TK3015TK3015 AZT, 3TC, DDCNoneM41L, D67N, L210W, T215Y V35M, T39D, E44D, V118I, K122E, I135L, K173A, Q174K, N175Y, D177E, V179A, E194K, G196E, T200A, I202V, Q207E, R211K, V245Q, D250E, I257V, A272S, T286A, K287X, E291D, V292I, I293V, H315FC
 TK3024TK3024 AZT, 3TC, D4T, DDINoneM41L, T215Y K13KM, K22X, L26LF, V35T, E36A, T39E, S48T, V118VI, K122E, K166R, K173A, Q174K, D177E, T200A, Q207E, R211K, V245Q, A272P, K277R, T286A, E291D, V292IC
 TK3032TK3032 AZT, 3TC, D4TNoneM41L, M184V, T215FV179DV8I, K20R, V35T, E36A, T39E, S48T, V118I, K122E, D123N, I135T, S162T, E169Q, K173T, Q174K, T200A, Q207E, R211K, F214L, P243T, V245Q, E248D, A272P, K275R, K277R, Q278H, T286A, E291D, V292I, I293V, D324E, I329LC
 TK4017TK4017 AZT, 3TC, ABCNoneM41L, M184V, L210W, T215NE138KV35T, T39G, K43R, A98S, K122E, D123S, A158S, S162A, K173A, D177E, T200A, Q207E, R211K, V245Q, A272P, T286A, E291D, V292IC
 PL4205691776 3TC, D4T, ABC, TDFNoneM41L, L210LW, T215F K20R, V35IT, T39E, S48T, K122E, D123S, I135T, T139TM, K173E, Q174QK, D177E, E194ED, G196K, T200A, I202V, Q207E, R211K, V241I, V245KR, E248D, D250E, A272P, K277R, E291D, I293V, I329VC
 PL833877353 AZT, DDI, 3TC, D4TNoneM41L, M184V, T215YA98GV35T, T39DE, S48T, V60I, K122E, D123S, I135V, K173A, D177E, T200A, Q207D, R211K, V245Q, A272P, K277KR, E291D, V292I, I293VC
Weber (2005)F56949F56949AY677552DDC, AZT, D4T, DDI, TDFNoneM41L, D67N, L210W, T215Y V21I, V35T, E36A, T39E, S48T, V118I, K122E, D123G, K173A, D177E, T200A, Q207E, R211K, V245Q, A272P, I274V, Q278H, K281R, T286A, E291D, V292I, I293V, K311RC
Marconi (2008)SW083sw083EU308093D4T, DDINoneM41L, D67N, V75VA, T215Y E44ED, S48T, K65KM, V118VI, K122E, D123G, S162Y, K173T, Q174R, D177E, T200A, E203EK, Q207E, R211K, V245QC
Pillay (2008)DR35DR35AY589892AZT, DDINoneM41L, T215Y V35T, E36EA, T39E, S48T, V90I, K122E, D123S, S162C, K173A, Q174K, D177E, T200A, Q207E, L228LR, Q242P, V245Q, K277R, T286A, E291D, V292I, I293VC
 DR60DR60AY589912AZT, D4T, DDINoneM41L, D67N, L210W, T215Y P4T, K20R, T27S, V35T, T39E, S48T, V60I, V118I, K122E, D123S, E138A, K173T, Q174K, T200A, Q207E, R211K, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, P294PQC
 DR1602ZA.DR16AY589877ABC, AZT, 3TCNoneM41L, D67N, T69D, M184V, L210W, T215FA98GV35T, T39E, E44D, S48T, E53D, V111I, V118VI, D121DG, K122E, D123S, E138EA, K173A, Q174K, D177E, G196E, T200A, E203V, Q207E, H208Y, R211K, V245Q, E248D, A272P, K277R, T286A, E291D, V292I, I293VC
 DR8103ZA.DR81AY589925D4T, DDINoneM41L, D67N, T215Y K11Q, V35T, T39E, S48T, V60I, K101Q, V118I, D121Y, K122E, D123G, I142V, S162C, K166R, K173A, D177E, T200A, Q207E, R211KC
 DR8803ZA.DR88AY589928D4T, DDINoneM41L, D67N, L210W, T215Y V35T, T39E, S48T, V60I, F77FS, G93GR, K101T, F116FL, V118I, S134I, K173A, D177E, T200A, Q207E, R211K, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, V317AC
Deshpande (2009)Pat23435artFJ530707AZT, 3TCNoneM41L, D67N, M184V, T215Y V35T, T39D, E44D, V60I, V90I, D121Y, K122E, S162Y, K173T, Q174K, D177E, I178L, T200A, Q207E, L210S, R211K, V245QC
 Pat21316RTFJ530728AZT, 3TCNoneM41L, D67N, K70R, M184V, T215F, K219QA98G, K101EQ, G190AK20R, E28EK, V35T, T39D, E44D, S48T, V60I, T69N, D121H, K122E, F124FV, I135T, K173A, Q174R, I178M, T200A, Q207E, R211RK, V245Q, L246WC
 Pat21217RTFJ530729AZT, 3TCNoneM41L, M184V, T215YA98GT7P, V35T, T39D, S48T, E53ED, V60I, V111VM, D121Y, K122E, I142V, S162D, K166R, E169K, K173A, D177E, V179I, T200A, I202V, Q207E, R211K, L228Q, V245Q, K249KMC
 Pat20920RTFJ530732D4T, 3TC, AZTNoneM41L, D67N, L74IV, M184V, L210W, T215Y, K219KNA98G, K101E, V108I, Y181CFGVK20R, K32T, V35K, T39D, E44D, S48T, V60I, V118I, D121Y, K122E, I135R, S162A, K173ST, V189I, T200A, E203V, Q207E, R211K, K223Q, T240K, V245QC
 Pat20527RTFJ530736D4T, 3TCNoneM41L, M184V, T215YY188LV35T, T39N, S48T, V60I, D121H, K122E, K173A, D177E, T200A, Q207E, R211K, V245Q, K249NC
 Pat155151RTFJ530786D4T, 3TCNoneM41L, M184V, T215YK103N, V106MK20R, V35T, T39D, S48T, V60I, I135T, K173A, Q174K, T200A, Q207EC
 Pat043329FJ530898AZT, 3TCNoneM41L, D67N, K70R, V75M, M184V, T215F, K219EG190AV35T, T39N, V60I, D121H, K122E, I135M, K173T, D177E, V179I, Q207E, L228H, V245QC
 Pat034352RTFJ530907AZT, 3TCNoneM41L, D67N, T69D, M184V, T215Y V35K, T39D, E44D, S48T, V60I, K101R, K102KN, D121Y, K122E, I135T, S162A, K173A, Q174R, D177DE, T200A, E203D, Q207E, R211K, L228Q, V245QC
 Pat004447RTFJ530937AZT, 3TCNoneM41L, D67N, T69D, K70R, M184V, T215Y V35T, T39D, V60I, D121Y, K122E, I135V, K173A, D177E, T200A, Q207E, R211K, V245QC
Rodrigues (2010)301_07BR07SC301GQ4013143TCNoneM41L, D67N, T69D, M184V, L210W, T215C I5V, V35T, E36A, T39D, K43R, E44D, V118I, K122E, D123S, I135T, K173T, D177E, T200A, E203D, Q207E, H208Y, R211KC
Van Zyl (2013)405411.ZA.GT1891KC423663TDF, FTCNoneM41L, D67DN, L74LV, M184V, T215YA98AG, Y188LV35IT, E36AD, T39DE, E40EK, S48T, V60VI, K64KHNQ, V106VI, K122E, D123DN, T128TI, W153W*, K173A, D177G, T200A, Q207N, R211K, V245QC
 174510.ZA.GT1410KC423208AZT, 3TC, DDINoneM41L, M184VK103N, V106MV35T, T39E, S48T, V60I, A98S, K122E, D123N, I135V, K173A, Q197K, T200E, Q207K, R211Q, F214L, E224EG, V245QC
 38410.ZA.WC073KC423019ABC, AZT, 3TCNoneM41L, T69D, L210W, T215YG190AV35T, T39N, S48T, V60I, F116S, K122E, D123N, I135T, K173A, Q174K, T200A, Q207E, R211K, V245QC
 53511.ZA.EC030KC423396ABC, AZT, 3TCNoneM41L, D67N, L74V, M184V, T215YA98G, K103N, K238TK20R, V35T, T39E, E44Y, S117A, K122E, D123S, I135L, E138A, S162CY, K173A, Q174K, Q207E, H208Y, R211K, W212R, V245K, D250EC
 525509.ZA.WC024KC424268AZT, 3TC, DDINoneM41L, D67N, K70R, T215Y, K219QK103N, V106M, Y188HV35T, E36A, T39E, V60I, K102R, K122E, D123S, I135V, I142T, T200A, E203K, Q207E, R211K, F214L, K223T, L228R, V245QC
 274511.ZA.GT1916KC423705TDF, AZTNoneM41LV106M, V179DE28A, V35T, T39E, V60I, K103R, K122E, D123S, I135L, K173T, Q174R, G196E, T200A, E204D, Q207E, R211K, F214L, V245Q, D250E, N255XC
 80310.ZA.WC077KC423053ABC, 3TCNoneM41L, D67N, V75M, M184V, T215YA98G, K101E, G190AE28K, K32I, V35T, T39D, S48T, V60I, K122E, D123S, K173A, Q174E, D177E, T200A, Q207E, H208Y, R211K, V245QC
 111808.ZA.EC010KC423322AZT, DDINoneM41L, D67N, K70R, V75M, L210W, T215F, K219QA98G, K101EE28K, K32I, V35T, T39E, V60I, K122E, D123DG, I135V, S162C, K173A, Q174K, D177E, I178L, G196GE, T200A, K201KR, E203A, Q207E, H208Y, R211K, L228H, V245QC
 314610.ZA.GT1132KC422962AZT, 3TC, DDINoneM41L, M184V, L210W, T215YA98G, V106IM, G190AV35T, T39N, S48T, V60I, K122E, K173T, V179T, I195L, G196GE, T200A, E203EK, Q207E, R211K, V245Q, D250EC
Acharya (2014)DGP175DGP175KJ185345TDF, 3TCNoneM41L, D67N, K70R, L74I, M184V, T215Y, K219QA98G, K103NV35T, T39D, E44D, S48T, V60I, K101R, V118I, D121Y, K122E, S162A, K173T, Q174K, D177E, I178M, T200A, E204A, Q207D, R211K, V245Q, A272P, K277R, T286A, E291D, V292IC
 DGP165DGP165KJ185335TDF, 3TCNoneM41L, D67N, M184V, T215YK103N, Y188LV35T, T39N, S48T, E53D, V60I, V118I, D121Y, K122E, S162A, K173A, D177E, V179T, T200A, Q207E, L210S, H221Y, V245Q, A272P, K277R, T286A, I293VC
 DGP162DGP162KJ185332TDF, 3TCNoneM41L, D67N, T69D, K70R, L74I, M184V, T215F, K219QY181I, G190SV35T, T39D, S48T, V60I, D121H, K122E, K173A, Q174R, D177E, I178L, Q197K, T200A, Q207E, R211K, V245Q, A272P, K277R, E291D, V292I, I293V, P294TC
 DGP121DGP121KJ185291AZT, 3TCNoneM41L, D67N, K70R, V75M, T215F, K219QV106M, V108I, G190AV35T, E36A, T39E, S48T, V60I, T69N, K101R, K122E, I135T, S162A, K166R, K173A, D177E, G196R, T200A, Q207A, V245Q, A272P, K277R, E291D, V292I, I293VC
 DGP119DGP119KJ185289TDF, 3TCNoneM41L, D67N, V75M, M184V, L210W, T215YK103NV35T, T39D, S48T, V60I, D121Y, K122E, I135R, S162A, K173A, D177E, T200A, I202V, Q207E, V245Q, A272P, K277R, K281R, T286A, E291D, V292I, I293VC
 DGP113DGP113KJ185283TDF, 3TCNoneM41L, D67N, T69D, M184V, L210W, T215FK101E, K103NV8I, V35T, T39D, S48T, V60I, D121Y, K122E, I135T, K173A, Q174R, D177E, I178L, T200A, Q207E, R211K, V245Q, A272P, K277R, T286A, E291D, V292IC
 DGP094DGP094KJ185264AZT, 3TCNoneM41L, D67N, K70R, M184V, T215YA98GV35T, T39D, S48T, V60VI, T69A, K101R, K122E, I135V, S162A, K173A, D177E, T200A, Q207E, V245Q, A272P, K277R, E291D, V292I, I293VC
 DGP093DGP093KJ185263AZT, 3TCNoneM41L, L74V, Y115F, M184V, T215YK103N, V106MV35T, E36A, T39D, S48T, V60I, L109I, D121H, K122E, K173I, D177E, I178M, T200A, Q207E, V245Q, A272P, K277R, T286A, E291D, V292I, I293VC
 DGP089DGP089KJ185259TDF, 3TCNoneM41L, D67N, K70R, V75M, M184V, T215F, K219EY188LV35T, E36A, T39E, S48T, V60I, K122E, D123S, I135T, K166R, K173A, D177E, T200A, Q207E, R211K, V245Q, A272P, K277R, K281R, E291D, V292I, I293VC
Grossman (2014)609609KF135112ABC, DDINoneM41L, D67N, L74IV, M184V, L210W, T215Y, K219NA98GT39E, K43Q, E44D, K122E, D123S, I142V, P150T, K173A, Q174K, D177E, T200A, E203K, Q207E, H208Y, R211K, K223E, V245QC
 943943 ABC, DDI, AZTNoneM41L T39E, E44D, K49KR, E53D, K64KR, A98S, K122E, D123SC
Steegen (2014)11ZAKS09011ZAKS090KJ176372ABC, 3TCNoneM41L, M184V, K219E V35T, E36A, T39E, S48T, V60I, K122E, D123G, T139A, K166R, K173T, D177E, V179VI, Q207E, R211K, V245K, A272P, K277R, T286A, E291D, V292I, I293V, E308EKC
 12ZAKS26112ZAKS261KJ176540TDF, D4T, 3TCNoneM41L, D67N, T69D, K70R, V75M, M184V, T215FK103N, V106MV35T, E36EA, T39AE, S48T, K49R, V60I, K122E, I135T, T139K, S162SN, K173T, Q174K, D177E, I178M, T200A, E203K, Q207E, H208Y, R211K, W212M, F214L, K223E, P243S, V245K, K249Q, A272P, E291D, I293V, P313PS, V317VA, S322A, Q334N, G335D, A355S, R356K, R358K, G359N, A376S, T377L, K390R, E399D, A400I, T403A, E404DC
 10ZAKS03810ZAKS038KJ176320D4T, 3TCNoneM41L, D67N, K70R, L74I, M184V, K219Q V35T, T39E, S48T, E53D, K122E, I135T, S162A, K173T, Q174K, V179I, T200A, Q207E, R211KT, F214L, P243PT, V245Q, A272P, K275R, Q278H, K281R, T286A, E291D, V292I, I293V, P294TC
Neogi (2016)91413.ZA.WC348KT593534ABC, 3TCNoneM41L, D67N, K70R, L74V, K219QL100I, K103N, P225HP14S, V35T, E36A, T39E, S48T, T69TN, V90I, K173A, Q174K, D177E, T200A, Q207K, D218DE, V245KC
 558113.ZA.EC755KT592886AZT, 3TCNoneM41L, D67G, V75M, M184V, L210W, T215YK101N, V108I, Y181C, G190A, F227LE28A, K32E, V35T, T39R, K43E, E44D, S48T, W88C, K122E, D123S, S162C, K173A, D177E, T200A, E203K, Q207E, R211RK, H221Y, K223E, L228R, V245QC
 58913.ZA.EC749KT592881TDF, 3TCNoneM41L, M184V, T215YY188LV8I, V35T, T39N, S48T, V60I, K122E, D123G, S162C, K173A, D177E, I178IL, V179VI, T200A, Q207S, R211K, V245QC
 67013.ZA.EC722KT592865D4T, 3TCNoneM41L, A62V, V75I, M184V, T215FV106M, G190A, F227LP4S, I31L, V35I, E36A, T39E, L109I, S162A, F171Y, K173A, Q174K, T200A, I202V, Q207A, R211K, V245QC
 711513.ZA.EC535KT592738AZT, 3TCNoneM41L, M184V, T215FY188LV35IT, E36*L, T39E, S48T, V60I, S68SG, L109I, K122E, D123G, K173A, Q174K, D177E, V179I, T200A, Q207E, R211K, D218E, K238R, V245QC
 86913.ZA.WC351KT593537TDF, AZT, 3TCNoneM41L, A62V, V75I, M184V, T215YA98G, V106M, Y188F, F227LI31L, V35I, T39E, K43R, E44D, S48T, L109I, V118I, D121HY, K122E, I135L, I142IV, S162A, K173T, D177E, V189I, T200A, I202V, Q207E, L210T, R211K, D218E, H221Y, V245QC
 548313.ZA.EC490KT592708TDF, 3TCNoneM41L, D67N, M184V, T215YK103N, G190AV35T, T39E, E44D, K101Q, K173A, Q174K, D177E, T200A, Q207E, L210S, R211K, V245KC