Reverse Transcriptase Inhibitors

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Reverse Transcriptase Inhibitors

Subtype	C
Gene	RT
Mutation	M41L
Rx	>= 1 NRTI (but no NNRTI)
IncludeMixtures	No

References	11
Patients	39
Isolates	44

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	NRTIs	NNRTIs	NRTIDRMs	NNRTIDRMs	OtherMut	Subtype
Yahi (2001)	NY_M4	M4	AY010469	AZT, 3TC	None	M41L, M184MV		V35T, E36A, T39E, K43R, S48T, E53D, K122E, D123S, I135T, I142V, K173AS, D177E, T200A, Q207E, R211K, T215X, L228H, K238R	C
	NY_M6	M6	AY010480	D4T, 3TC	None	M41L, M184V, T215Y		V35T, E36A, T39D, S48T, K122E, A158S, K173T, T200A, Q207E	C
Kantor (2002)	TCDD-27	TCDD-27	AY090853	AZT, 3TC	None	M41L, D67DN, K70KR, M184V, T215Y	A98AG	V35T, E36A, T39D, S48ST, V60I, K122E, D123N, I135T, K173A, Q174K, D177E, T200A, L205LF, Q207E, R211K	C
	TCDD-35	TCDD-35_1	AY090860	DDC, AZT, 3TC	None	M41L, K70KR, M184V, T215Y		V35T, E36A, T39E, S48T, E53D, V60I, K122E, D123S, I135V, S162C, K166R, I167IV, K173A, Q174K, D177E, I178L, T200A, Q207E, R211K, L228H	C
Weber (2003)	85H	610185H-0	AY140820	NRTI	None	M41L, L210W, T215Y		V35T, T39E, S48T, A98S, K122E, D123N, I135T, K173T, Q174K, T200A, Q207N, R211K, V245Q, A272Q, E291D, V292I, I293V	C
		610185H-12	AY140821	NRTI, AZT, 3TC	None	M41L, D67N, L210W, T215Y		V35T, T39E, S48T, A98S, K122E, D123N, I135T, K173T, Q174K, T200A, Q207N, R211K, V245Q, A272Q, E291D, V292I, I293V	C
		610185H-48	AY140823	NRTI, AZT, 3TC	None	M41L, D67N, M184V, L210W, T215Y		V35T, T39E, S48T, A98S, V118I, K122E, D123N, I135T, K173T, Q174K, N175Y, G196E, T200A, Q207N, R211K, V245Q, A272Q, E291D, V292I, I293V	C
Montes (2004)	MB_patVID	99_VID711	AJ578177	D4T, DDI, AZT	None	M41L		V35T, E36A, T39E, S48T, K122E, D123E, K173V, D177E, T200A, Q207E, R211K, V245Q	C
Richard (2004)	RNJCR09	RNJCR09	AY556758	AZT, 3TC, D4T, DDI	None	M41L, D67N, K70R, M184V		P4T, V35T, T39E, K122E, D123S, A158S, K173A, D177E, T200A	C
Non-B Workgroup (2005)	UK1154	UK1154	AY901331	AZT, DDI, D4T, 3TC	None	M41L, M184V, T215Y		V8I, V35T, T39E, K122E, I135T, A158S, K173A, Q174R, D177E, I178M, T200A, Q207E, R211Q	C
	IL80	IL80	AY901353	AZT, DDI, DDC, D4T, ABC, 3TC	None	M41L, D67N, M184V, L210W, T215Y	A98G	T39E, S48T, V60I, G112X, P119PH, K122E, D123A, F124I, A158S, K173A, Q174K, D177E, T200A, Q207E, R211K, V245Q	C
	IL81	IL81	AY901354	AZT, 3TC, ABC, DDI	None	M41L, D67DN, M184V, L210W, T215Y		T39DE, K43KQ, E44D, A98S, V118VI, K122E, K173T, D177E, G196E, T200A, Q207E, R211K, V245Q	C
	IL128	IL128b		AZT, 3TC, DDI	None	M41L, M184MV, T215Y	K238KT	T39E, K122E, D123S, I135T, K173T, D177E, T200A, Q207E, V245Q	C
		IL128c		AZT, 3TC, DDI	None	M41L, M184MV, T215TN		T39E, K122E, D123S, I135T, A158AS, E169EA, K173AT, Q174QK, D177E, T200A, Q207E, V245A	C
		IL128d		AZT, 3TC, DDI	None	M41L, D67DN, K70KR, M184MV, T215NY		T39E, E44D, K101KI, K122E, D123S, I135T, K173AT, D177E, T200A, Q207E, D237DE, V245Q	C
		IL128e	AY901356	AZT, 3TC, DDI	None	M41L, D67N, K70R, T215Y	Y181S	T39E, E44D, V118VI, K122E, D123S, I135T, W153L, S163C, K173T, D177E, T200A, Q207E, K223KR, Y232*, W239R	C
	SA75_DR16	SA75_DR16	AY901709	ABC, AZT, 3TC	None	M41L, D67N, T69D, M184V, L210W, T215F	A98G	V35T, T39E, E44D, S48T, E53D, V111I, V118VI, D121DG, K122E, D123S, E138EA, K173A, Q174K, D177E, G196E, T200A, E203V, Q207E, H208Y, R211K, V245Q, E248D, A272P, K277R, T286A, E291D, V292I, I293V	C
	IL287	IL287	AY901765	AZT, 3TC, ABC, DDI	None	M41L, T215Y		T39E, K102Q, K122E, D123S, I135IT, A158S, S162A, K173AV, Q174K, D177E, T200A, Q207E, R211K, V245Q	C
	IL433	IL433b	AY901779	DDC, AZT	None	M41L, L210W, T215Y		T39E, V118VI, K122E, D123E, A158S, K173A, Q174K, D177E, I178M, T200A, Q207E, L228LR, V245Q	C
	IL477	IL477	AY901780	D4T, DDI	None	M41L, D67N, L210W, T215Y		S48T, K65KE, V118VI, K122E, D123S, I135IT, K173T, D177E, T200A, Q207E, R211RK, V245Q	C
	IL719	IL719	AY901785	AZT, 3TC	None	M41L, T215Y		T39E, K49R, I50V, K122E, D123G, A158S, K173A, D177E, G196K, T200A, Q207E, V245Q	C
	TK3015	TK3015		AZT, 3TC, DDC	None	M41L, D67N, L210W, T215Y		V35M, T39D, E44D, V118I, K122E, I135L, K173A, Q174K, N175Y, D177E, V179A, E194K, G196E, T200A, I202V, Q207E, R211K, V245Q, D250E, I257V, A272S, T286A, K287X, E291D, V292I, I293V, H315F	C
	TK3024	TK3024		AZT, 3TC, D4T, DDI	None	M41L, T215Y		K13KM, K22X, L26LF, V35T, E36A, T39E, S48T, V118VI, K122E, K166R, K173A, Q174K, D177E, T200A, Q207E, R211K, V245Q, A272P, K277R, T286A, E291D, V292I	C
	TK3032	TK3032		AZT, 3TC, D4T	None	M41L, M184V, T215F	V179D	V8I, K20R, V35T, E36A, T39E, S48T, V118I, K122E, D123N, I135T, S162T, E169Q, K173T, Q174K, T200A, Q207E, R211K, F214L, P243T, V245Q, E248D, A272P, K275R, K277R, Q278H, T286A, E291D, V292I, I293V, D324E, I329L	C
	TK4017	TK4017		AZT, 3TC, ABC	None	M41L, M184V, L210W, T215N	E138K	V35T, T39G, K43R, A98S, K122E, D123S, A158S, S162A, K173A, D177E, T200A, Q207E, R211K, V245Q, A272P, T286A, E291D, V292I	C
	PL42056	91776		3TC, D4T, ABC, TDF	None	M41L, L210LW, T215F		K20R, V35IT, T39E, S48T, K122E, D123S, I135T, T139TM, K173E, Q174QK, D177E, E194ED, G196K, T200A, I202V, Q207E, R211K, V241I, V245KR, E248D, D250E, A272P, K277R, E291D, I293V, I329V	C
	PL8338	77353		AZT, DDI, 3TC, D4T	None	M41L, M184V, T215Y	A98G	V35T, T39DE, S48T, V60I, K122E, D123S, I135V, K173A, D177E, T200A, Q207D, R211K, V245Q, A272P, K277KR, E291D, V292I, I293V	C
Weber (2005)	F56949	F56949	AY677552	DDC, AZT, D4T, DDI, TDF	None	M41L, D67N, L210W, T215Y		V21I, V35T, E36A, T39E, S48T, V118I, K122E, D123G, K173A, D177E, T200A, Q207E, R211K, V245Q, A272P, I274V, Q278H, K281R, T286A, E291D, V292I, I293V, K311R	C
Marconi (2008)	SW083	sw083	EU308093	D4T, DDI	None	M41L, D67N, V75VA, T215Y		E44ED, S48T, K65KM, V118VI, K122E, D123G, S162Y, K173T, Q174R, D177E, T200A, E203EK, Q207E, R211K, V245Q	C
Pillay (2008)	DR35	DR35	AY589892	AZT, DDI	None	M41L, T215Y		V35T, E36EA, T39E, S48T, V90I, K122E, D123S, S162C, K173A, Q174K, D177E, T200A, Q207E, L228LR, Q242P, V245Q, K277R, T286A, E291D, V292I, I293V	C
	DR60	DR60	AY589912	AZT, D4T, DDI	None	M41L, D67N, L210W, T215Y		P4T, K20R, T27S, V35T, T39E, S48T, V60I, V118I, K122E, D123S, E138A, K173T, Q174K, T200A, Q207E, R211K, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, P294PQ	C
	DR16	02ZA.DR16	AY589877	ABC, AZT, 3TC	None	M41L, D67N, T69D, M184V, L210W, T215F	A98G	V35T, T39E, E44D, S48T, E53D, V111I, V118VI, D121DG, K122E, D123S, E138EA, K173A, Q174K, D177E, G196E, T200A, E203V, Q207E, H208Y, R211K, V245Q, E248D, A272P, K277R, T286A, E291D, V292I, I293V	C
	DR81	03ZA.DR81	AY589925	D4T, DDI	None	M41L, D67N, T215Y		K11Q, V35T, T39E, S48T, V60I, K101Q, V118I, D121Y, K122E, D123G, I142V, S162C, K166R, K173A, D177E, T200A, Q207E, R211K	C
	DR88	03ZA.DR88	AY589928	D4T, DDI	None	M41L, D67N, L210W, T215Y		V35T, T39E, S48T, V60I, F77FS, G93GR, K101T, F116FL, V118I, S134I, K173A, D177E, T200A, Q207E, R211K, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, V317A	C
Deshpande (2009)	Pat234	35art	FJ530707	AZT, 3TC	None	M41L, D67N, M184V, T215Y		V35T, T39D, E44D, V60I, V90I, D121Y, K122E, S162Y, K173T, Q174K, D177E, I178L, T200A, Q207E, L210S, R211K, V245Q	C
	Pat213	16RT	FJ530728	AZT, 3TC	None	M41L, D67N, K70R, M184V, T215F, K219Q	A98G, K101EQ, G190A	K20R, E28EK, V35T, T39D, E44D, S48T, V60I, T69N, D121H, K122E, F124FV, I135T, K173A, Q174R, I178M, T200A, Q207E, R211RK, V245Q, L246W	C
	Pat212	17RT	FJ530729	AZT, 3TC	None	M41L, M184V, T215Y	A98G	T7P, V35T, T39D, S48T, E53ED, V60I, V111VM, D121Y, K122E, I142V, S162D, K166R, E169K, K173A, D177E, V179I, T200A, I202V, Q207E, R211K, L228Q, V245Q, K249KM	C
	Pat209	20RT	FJ530732	D4T, 3TC, AZT	None	M41L, D67N, L74IV, M184V, L210W, T215Y, K219KN	A98G, K101E, V108I, Y181CFGV	K20R, K32T, V35K, T39D, E44D, S48T, V60I, V118I, D121Y, K122E, I135R, S162A, K173ST, V189I, T200A, E203V, Q207E, R211K, K223Q, T240K, V245Q	C
	Pat205	27RT	FJ530736	D4T, 3TC	None	M41L, M184V, T215Y	Y188L	V35T, T39N, S48T, V60I, D121H, K122E, K173A, D177E, T200A, Q207E, R211K, V245Q, K249N	C
	Pat155	151RT	FJ530786	D4T, 3TC	None	M41L, M184V, T215Y	K103N, V106M	K20R, V35T, T39D, S48T, V60I, I135T, K173A, Q174K, T200A, Q207E	C
	Pat043	329	FJ530898	AZT, 3TC	None	M41L, D67N, K70R, V75M, M184V, T215F, K219E	G190A	V35T, T39N, V60I, D121H, K122E, I135M, K173T, D177E, V179I, Q207E, L228H, V245Q	C
	Pat034	352RT	FJ530907	AZT, 3TC	None	M41L, D67N, T69D, M184V, T215Y		V35K, T39D, E44D, S48T, V60I, K101R, K102KN, D121Y, K122E, I135T, S162A, K173A, Q174R, D177DE, T200A, E203D, Q207E, R211K, L228Q, V245Q	C
	Pat004	447RT	FJ530937	AZT, 3TC	None	M41L, D67N, T69D, K70R, M184V, T215Y		V35T, T39D, V60I, D121Y, K122E, I135V, K173A, D177E, T200A, Q207E, R211K, V245Q	C
Rodrigues (2010)	301_07	BR07SC301	GQ401314	3TC	None	M41L, D67N, T69D, M184V, L210W, T215C		I5V, V35T, E36A, T39D, K43R, E44D, V118I, K122E, D123S, I135T, K173T, D177E, T200A, E203D, Q207E, H208Y, R211K	C

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