<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype C
Gene RT
Mutation E40D
Rx >= 1 NRTI
(but no NNRTI)
IncludeMixtures No
References 10
Patients 19
Isolates 21
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Shulman (2001)302-150450150450AY901228AZTNone  V35T, E36A, T39E, E40D, D123E, K173A, D177E, T200A, Q207E, V245Q, P247PT, D250DE, A272P, K277R, T286A, E291D, V292I, I293V, P294TC
Yahi (2001)NY_M3M3AY010476DDC, 3TCNoneD67N, K70R, M184V, K219Q K20KR, V35T, E36A, T39E, E40D, K43R, T69TN, K122E, D123S, A158S, K173A, Q174QR, D177DE, T200A, E203EK, Q207E, R211K, F214L, D218DE, L228HC
Soares (2003)BR49BR49AY275735DDC, AZT, 3TC, D4TNone  I2V, V35T, E36A, T39E, E40D, S48T, K122E, I135T, K173T, D177E, T200A, Q207E, R211K, F214LC
Non-B Workgroup (2005)SA52_1237SA52_1237AY589826D4T, DDINone  V35T, E36A, T39E, E40D, S48T, V60I, D123S, K173A, D177E, T200A, Q207E, R211K, V245Q, A272P, K277R, E291D, V292I, I293VC
 SA62_10691069_6WAY589803D4TNone  V35T, E36A, T39E, E40D, S48T, V60I, K122E, K173A, D177E, T200A, Q207E, R211K, F214L, V245Q, A272S, K277R, E291D, V292I, I293VC
  SA62_1069AY589804D4T, DDINone  V35T, E36A, T39E, E40D, S48T, V60I, K122E, K173A, D177E, T200A, Q207E, R211K, F214L, L228R, V245Q, A272S, K277R, E291D, V292I, I293VC
 IL92IL92AY901744AZT, 3TCNone  T39E, E40D, K43KE, I47N, S48FL, A98S, K101Q, K122E, D123G, K166R, K173A, D177EG, T200A, Q207E, V245QC
von Wyl (2007)374822080EF449879NRTINoneM184V K20R, E28A, V35T, T39E, E40D, K43R, K122E, D123S, I135V, K173A, Q174K, D177E, I178M, G196K, T200V, Q207E, R211KC
Pillay (2008)DR7403ZA.DR74AY589921DDINone  V35T, E36A, T39D, E40D, S48T, D121H, K122E, I135T, K173A, D177E, Q197QK, T200A, Q207E, V245Q, T286A, E291D, V292I, I293V, P313T, V314I, V317AC
Ndembi (2010)DT3548_05_P13548GQ409622ABC, AZT, 3TC, D4TNoneY115F, M184V V35T, E36A, T39E, E40D, S48T, E53D, V118I, K122E, K173A, Q174K, T200A, Q207N, R211K, F214L, L228QC
Green (2011)707PKE40F707PKE40FHM623527D4T, 3TCNoneM184VY181YCT27TS, V35T, E36A, T39E, E40D, K101R, K122E, D123N, I135T, T139A, D177E, T200A, Q207E, F214L, P243T, V245Q, A272S, T286A, E291D, V292I, I293V, P294T, D324EC
Van Zyl (2013)12931097KC422875D4T, 3TCNone  V35T, E36A, T39E, E40D, K122E, D123G, K173A, D177E, G196K, T200A, Q207A, R211K, V245QC
 1255898KC424344D4T, 3TCNoneA62AV, M184V V35T, E36A, T39E, E40D, S48T, T69N, K122E, D123N, I135V, I159IV, K173T, Q174K, D177E, G196E, Q207D, R211K, K219KT, P243T, V245QC
 14822669KC423774ABC, 3TCNoneM184IK103NP4T, V8I, K20R, V35T, E36A, T39E, E40D, S48T, V60I, K122E, T165I, K173A, Q174K, D177E, V179I, T200A, Q207A, R211K, F214L, V245QC
 16222799KC423835D4T, 3TCNone  P9PS, V35T, E36A, T39E, E40D, S48T, K122E, D123G, K173A, Q174K, D177G, T200A, Q207E, L210S, V245QC
 1139223KC423685D4T, 3TCNoneM184V V35T, E36A, T39E, E40D, S48T, V60I, K122E, D123S, I135V, K173A, D177E, I178M, T200A, E204K, Q207E, R211K, F214L, V245QC
 1137706KC424236D4T, 3TCNoneM184V V35T, E36A, T39E, E40D, K122E, D123S, I135T, K173A, Q174K, D177E, G196K, T200A, Q207E, R211K, F214L, V245QC
 16322976KC423913D4T, 3TCNone V106MV21I, V35T, E36A, T39EG, E40D, W88S, K122E, D123N, K173A, Q174K, T200A, R206RK, Q207E, F214L, V245L, D250EC
 13491140KC422908D4T, 3TCNoneM184VK103NK20R, V35T, E36A, T39E, E40D, S48T, V60I, K122E, D123G, K166R, K173A, D177E, I195L, T200A, Q207E, R211K, V245QC
Grossman (2014)11041104KF134945ABC, DDINone  T39E, E40D, S48T, D121Y, K122E, D123E, K173AT, Q174K, D177E, T200A, Q207E, R211K, V245KQC
  1104KF134947ABC, DDINone  T39E, E40D, S48T, D121Y, K122E, D123E, K173AT, Q174K, D177E, T200A, Q207E, R211K, V245QC