<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype C
Gene RT
Mutation E40D
Rx >= 1 NRTI
(but no NNRTI)
IncludeMixtures No
References 13
Patients 41
Isolates 44
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Shulman (2001)302-150450150450AY901228AZTNone  V35T, E36A, T39E, E40D, D123E, K173A, D177E, T200A, Q207E, V245Q, P247PT, D250DE, A272P, K277R, T286A, E291D, V292I, I293V, P294TC
Yahi (2001)NY_M3M3AY010476DDC, 3TCNoneD67N, K70R, M184V, K219Q K20KR, V35T, E36A, T39E, E40D, K43R, T69TN, K122E, D123S, A158S, K173A, Q174QR, D177DE, T200A, E203EK, Q207E, R211K, F214L, D218DE, L228HC
Soares (2003)BR49BR49AY275735DDC, AZT, 3TC, D4TNone  I2V, V35T, E36A, T39E, E40D, S48T, K122E, I135T, K173T, D177E, T200A, Q207E, R211K, F214LC
Non-B Workgroup (2005)SA52_1237SA52_1237AY589826D4T, DDINone  V35T, E36A, T39E, E40D, S48T, V60I, D123S, K173A, D177E, T200A, Q207E, R211K, V245Q, A272P, K277R, E291D, V292I, I293VC
 SA62_10691069_6WAY589803D4TNone  V35T, E36A, T39E, E40D, S48T, V60I, K122E, K173A, D177E, T200A, Q207E, R211K, F214L, V245Q, A272S, K277R, E291D, V292I, I293VC
  SA62_1069AY589804D4T, DDINone  V35T, E36A, T39E, E40D, S48T, V60I, K122E, K173A, D177E, T200A, Q207E, R211K, F214L, L228R, V245Q, A272S, K277R, E291D, V292I, I293VC
 IL92IL92AY901744AZT, 3TCNone  T39E, E40D, K43KE, I47N, S48FL, A98S, K101Q, K122E, D123G, K166R, K173A, D177EG, T200A, Q207E, V245QC
von Wyl (2007)374822080EF449879NRTINoneM184V K20R, E28A, V35T, T39E, E40D, K43R, K122E, D123S, I135V, K173A, Q174K, D177E, I178M, G196K, T200V, Q207E, R211KC
Pillay (2008)DR7403ZA.DR74AY589921DDINone  V35T, E36A, T39D, E40D, S48T, D121H, K122E, I135T, K173A, D177E, Q197QK, T200A, Q207E, V245Q, T286A, E291D, V292I, I293V, P313T, V314I, V317AC
Ndembi (2010)DT3548_05_P13548GQ409622ABC, AZT, 3TC, D4TNoneY115F, M184V V35T, E36A, T39E, E40D, S48T, E53D, V118I, K122E, K173A, Q174K, T200A, Q207N, R211K, F214L, L228QC
Green (2011)707PKE40F707PKE40FHM623527D4T, 3TCNoneM184VY181YCT27TS, V35T, E36A, T39E, E40D, K101R, K122E, D123N, I135T, T139A, D177E, T200A, Q207E, F214L, P243T, V245Q, A272S, T286A, E291D, V292I, I293V, P294T, D324EC
Van Zyl (2013)535312.ZA.EC188KC423854TDF, 3TCNoneM184V V35T, E36A, T39E, E40D, S48T, V60I, V90VI, K122E, D123G, S162F, K166KR, K173A, D177E, T200A, Q207E, R211K, V245QC
 345308.ZA.GT482KC423685D4T, 3TCNoneM184V V35T, E36A, T39E, E40D, S48T, V60I, K122E, D123S, I135V, K173A, D177E, I178M, T200A, E204K, Q207E, R211K, F214L, V245QC
 358009.ZA.GT848KC424344D4T, 3TCNoneA62AV, M184V V35T, E36A, T39E, E40D, S48T, T69N, K122E, D123N, I135V, I159IV, K173T, Q174K, D177E, G196E, Q207D, R211K, K219KT, P243T, V245QC
 395712.ZA.GT2066KC423774ABC, 3TCNoneM184IK103NP4T, V8I, K20R, V35T, E36A, T39E, E40D, S48T, V60I, K122E, T165I, K173A, Q174K, D177E, V179I, T200A, Q207A, R211K, F214L, V245QC
 401911.ZA.GT1642KC423436AZT, 3TCNoneK65RK103N, Y181C, G190AP14A, K20R, V35T, E36A, T39E, E40D, S68N, W88C, K101Q, K122E, D123N, I135T, I142V, T200A, I202IV, Q207A, R211K, F214L, H221Y, V245L, D250EC
 74512.ZA.WC220KC423913D4T, 3TCNone V106MV21I, V35T, E36A, T39EG, E40D, W88S, K122E, D123N, K173A, Q174K, T200A, R206RK, Q207E, F214L, V245L, D250EC
 344909.ZA.GT688KC424236D4T, 3TCNoneM184V V35T, E36A, T39E, E40D, K122E, D123S, I135T, K173A, Q174K, D177E, G196K, T200A, Q207E, R211K, F214L, V245QC
 72712.ZA.WC211KC423835D4T, 3TCNone  P9PS, V35T, E36A, T39E, E40D, S48T, K122E, D123G, K173A, Q174K, D177G, T200A, Q207E, L210S, V245QC
 362609.ZA.GT1023KC422875D4T, 3TCNone  V35T, E36A, T39E, E40D, K122E, D123G, K173A, D177E, G196K, T200A, Q207A, R211K, V245QC
 227911.ZA.GT1622KC423417AZT, 3TCNoneM184MV E6D, V35T, E36A, T39E, E40D, S48T, K122E, D123N, K173T, Q174KR, I178IM, T200A, Q207E, R211K, V245QC
 346811.ZA.GT1544KC423329D4T, 3TCNoneM184V E28EA, V35T, E36A, T39E, E40D, S48T, V60I, K122E, D123G, S162A, K173T, T200TA, Q207E, V245K, D250EC
 11112.ZA.EC176KC423817TDF, AZTNoneL74V, M184VK103N, V106M, F227FLE6K, K32R, V35T, T39E, E40D, K122E, D123E, S162C, D177E, T200A, Q207E, R211K, V245QC
 106211.ZA.EC133KC423745TDF, 3TCNoneM184VY188LV35T, E36A, T39E, E40D, S48T, K122E, D123N, N147NI, S162A, K173T, D177E, T200A, Q207E, V245QC
 371810.ZA.GT1063KC422908D4T, 3TCNoneM184VK103NK20R, V35T, E36A, T39E, E40D, S48T, V60I, K122E, D123G, K166R, K173A, D177E, I195L, T200A, Q207E, R211K, V245QC
 23511.ZA.GT1949KC423729TDF, 3TCNoneA62AV, K65R, M184VK101E, V106M, V108VI, F227LK22R, E28K, V35T, E36A, T39E, E40D, S68N, W88C, A98S, L109LI, K122E, D123N, K173A, D177G, T200A, Q207EK, R211K, F214FL, D218E, V245EC
 304707.ZA.GT110KC424172AZT, DDINone  V35T, E36A, T39E, E40D, K122E, D123G, K173A, D177E, G196K, T200A, Q207A, R211K, V245Q, A272P, K277R, L283I, V292I, I293V, Q334H, G335DC
  07.ZA.GT345KC424138AZT, DDINone  K32KR, V35T, E36A, T39E, E40D, K122E, D123G, K173A, D177E, G196K, Q197H, T200A, Q207A, R211K, V245QC
 316209.ZA.GT830KC424333AZT, DDINone  V35T, E36A, T39E, E40D, S48T, K122E, D123N, T165L, K173A, T200A, Q207E, D250EC
 247810.ZA.GT1154KC422992AZT, 3TCNoneM184VA98G, K103NK20R, V35T, E36A, T39E, E40D, S48T, V60I, W88C, K122E, D123N, I135L, S163T, K173T, Q174K, T200A, Q207E, F214L, V245EC
Grossman (2014)11041104KF134945ABC, DDINone  T39E, E40D, S48T, D121Y, K122E, D123E, K173AT, Q174K, D177E, T200A, Q207E, R211K, V245KQC
  1104KF134947ABC, DDINone  T39E, E40D, S48T, D121Y, K122E, D123E, K173AT, Q174K, D177E, T200A, Q207E, R211K, V245QC
 17511751 TDF, FTCNone  T39E, E40D, K43R, K49KR, K122E, D123DGNS, I135M, S162C, K173ST, D177E, I178L, T200A, Q207E, R211K, V245QC
Steegen (2014)12ZAKS33212ZAKS332KJ176611ABC, 3TCNone  V35T, T39E, E40D, S48T, K82KR, A98S, V118I, K122E, I135R, K173AT, Q174K, D177E, V179I, T200A, I202V, Q207E, R211K, F214L, V245Q, A272P, K281R, T286A, I293V, G333S, Q334DE, I341IV, R356K, G359T, T377Q, K390R, A400L, E404DC
 10ZAKS03910ZAKS039KJ176321D4T, 3TCNoneM184V V35T, T39A, E40D, S48T, A98S, K122E, D123E, K173A, Q174N, D177E, T200A, Q207N, R211K, V245Q, E248D, D250E, S251N, A272P, K277R, T286A, V292I, I293V, T296TSC
 11ZAKS14311ZAKS143KJ176425D4T, 3TCNoneM184V V21I, K32KR, V35T, E36A, T39E, E40D, S48T, K122E, D123S, E138A, K173I, Q174K, T200A, Q207DE, R211RK, V245Q, E248DN, A272P, K277R, T286A, E291D, V292I, I293V, P313QC
 12ZAKS23812ZAKS238KJ176517D4T, 3TCNoneM184V K20R, V35T, E36A, T39E, E40D, S48T, K122E, D123S, I135T, S162A, K173A, T200A, Q207K, R211A, V245Q, A272P, K277R, T286A, V292I, I293V, E297K, I326V, Q334D, G335DC
Rossouw (2015)RP154RP154KT032055D4T, 3TCNoneM184V V21I, V35T, E36A, T39E, E40D, S48T, W88S, I135IV, S162Y, K166R, K173A, Q174K, D177E, I178L, T200A, Q207R, R211Q, V245Q, A272P, T286A, E291D, V292I, I293VC
 RP159RP159KT032057D4T, 3TCNoneD67N, M184V V35I, T39E, E40D, S48T, E53D, D121Y, K122E, T139R, S162C, K173T, Q174K, T200A, Q207D, R211RK, F214L, V245Q, E248D, A272P, K277R, T286A, E291D, V292I, I293IV, L303IC
Neogi (2016)85313.ZA.WC317KT593512TDF, 3TCNone  K20R, V35R, E36A, T39E, E40D, S48T, K122E, D123S, I135V, I142IT, S162C, K173A, D177G, T200A, Q207E, R211Q, V245QC
 61613.ZA.EC689KT592845D4T, 3TCNone  K11N, V35T, T39E, E40D, V60I, K122E, D123S, K173T, Q174K, D177E, T200A, Q207K, R211Q, V245QC
 408813.ZA.GT3082KT593348ABC, 3TCNoneL74V, M184V V35T, E36A, T39E, E40D, S48T, K122E, D123G, K173T, D177E, T200A, Q207K, V245QC
 220213.ZA.GT2821KT593163AZT, 3TCNoneM184V P4S, V35T, E36A, T39E, E40D, S48T, K166R, K173V, T200A, Q207E, L228V, V245QC
 312413.ZA.GT2751KT593113TDF, 3TCNone K103N, P225HE6D, K20KR, V35T, T39E, E40D, V60VI, K122E, D123S, I135IL, E138EG, K173T, T200A, E204D, Q207K, R211K, V245QC