<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype C
Gene RT
Mutation K219Q
Rx >= 1 NRTI
(but no NNRTI)
IncludeMixtures No
References 14
Patients 30
Isolates 31
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Yahi (2001)NY_M3M3AY010476DDC, 3TCNoneD67N, K70R, M184V, K219Q K20KR, V35T, E36A, T39E, E40D, K43R, T69TN, K122E, D123S, A158S, K173A, Q174QR, D177DE, T200A, E203EK, Q207E, R211K, F214L, D218DE, L228HC
Kantor (2002)TCDD-23TCDD-23_1AY090850DDC, AZTNoneD67G, K70R, K219Q V35T, T39E, S48T, K64N, V90I, K122E, D123S, E138A, K173T, Q174K, T200A, E203K, Q207E, R211K, F214L, L228R, V245E, E248DC
Snoeck (2002)BE16aBE16aAF339010AZT, 3TCNoneD67N, K70R, M184V, K219Q V35T, T39N, S48SL, V60I, P119PL, D121DH, K122KE, D123DGNS, R125RG, I135R, N136NT, K173I, Q174K, D177E, T200A, Q207E, R211K, F214LC
Montes (2004)MB_patMUK03_MUK733AJ577958DDI, AZT, D4T, 3TCNoneD67N, K219Q K20G, V35T, E36A, T39E, K103R, K122E, D123S, I135T, K173A, D177E, I178V, T200V, E203K, Q207E, R211K, F214LC
Non-B Workgroup (2005)SA84_DR29SA84_DR29AY901717AZT, 3TCNoneD67N, K70R, K219QK103N, G190AV35T, E36A, T39E, S48T, V60I, K122E, D123G, V148VG, K173A, D177E, T200A, E203Q, Q207E, H221Y, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, V317AC
 TK1008TK1008 AZT, DDI, 3TCNoneD67N, K70R, M184V, K219QK101KEV35T, E40D, K43R, K49R, V60I, K122E, D123S, K173A, D177E, T200AE, E204K, Q207E, R211K, V245Q, A272P, K277R, L282C, A288S, I293V, E297A, N306ND, H315NC
Weber (2005)M66914M66914AY677584AZT, DDI, 3TC, D4TNoneD67N, K70R, M184V, T215V, K219Q V21I, V35T, T39E, K43R, T69TS, K122E, D123S, I135V, K173T, Q174K, D177E, Q207E, V245Q, K249Q, A272P, T286A, E291D, V292I, I293VC
Sen (2007)T076NPT76-PLEF186980AZT, D4T, 3TC, DDINoneD67G, K70R, L74V, K219Q V35T, E36A, T39D, S48T, K64N, D121Y, K122E, I135T, T165I, R172K, K173A, Q174R, D177E, I178L, T200A, E203K, Q207E, R211K, F214L, D218E, Q242QK, V245Q, A272P, K277R, L283I, I293V, G335D, R356K, G359AT, A360AT, V365VI, K390KR, A400T, E404DC
Pillay (2008)DR7603ZA.DR76AY589922D4T, DDINoneD67N, K70R, K219Q V35T, E36A, T39E, K64KN, K122E, D123DG, K173A, Q174K, D177E, I178L, T200A, Q207KN, L210LF, R211KM, V245Q, A272P, K277R, Q278H, T286A, I293VC
Deshpande (2009)Pat21316RTFJ530728AZT, 3TCNoneM41L, D67N, K70R, M184V, T215F, K219QA98G, K101EQ, G190AK20R, E28EK, V35T, T39D, E44D, S48T, V60I, T69N, D121H, K122E, F124FV, I135T, K173A, Q174R, I178M, T200A, Q207E, R211RK, V245Q, L246WC
 Pat18369RTFJ530758AZT, 3TC, D4TNoneD67N, K70R, M184V, K219QV106M, G190AT27S, V35T, E36A, T39D, S48T, V60I, T69S, D121Y, K122E, I135T, E138Q, S162A, K166R, K173A, D177E, V179I, G196K, Q197R, R199RG, T200A, Q207G, R211K, F214LC
Kassaye (2009)TCDD-23TC23_2003FJ445712DDC, AZTNoneD67G, T69T_T, K70R, K219Q V35T, T39E, S48T, V60I, K64N, K103KR, V118I, K122E, D123S, E138A, T139A, K173T, Q174K, T200A, I202V, E203K, Q207E, R211K, F214L, D218E, L228HR, V245E, E248DC
Van Zyl (2013)17512.ZA.NL028KC423893TDF, AZT, 3TCNoneK70R, M184V, K219QL100I, K103NT27S, V35T, T39E, S48T, T69N, K122E, D123N, A158AS, T165L, K173M, Q174R, T200A, I202V, Q207E, R211K, F214L, L228RC
 152311.ZA.GT1849KC423630AZT, 3TC, DDINoneM184V, K219QK101E, K103N, G190AT27S, E29G, V35T, E36A, T39E, V60I, S105T, V118I, I135T, E138A, I142V, K173L, Q174K, V189VI, T200A, R211K, F214L, V245QC
 525509.ZA.WC024KC424268AZT, 3TC, DDINoneM41L, D67N, K70R, T215Y, K219QK103N, V106M, Y188HV35T, E36A, T39E, V60I, K102R, K122E, D123S, I135V, I142T, T200A, E203K, Q207E, R211K, F214L, K223T, L228R, V245QC
 327211.ZA.GT1915KC423704AZT, 3TC, DDINoneD67N, T69D, K70R, V75I, T215F, K219Q V35T, T39E, V60I, W88C, K122E, I132L, K173A, D177E, I178L, G196E, T200A, K201R, E203ED, E204K, Q207E, F214L, L228R, V245Q, E248DC
 60209.ZA.EC015KC424406TDF, AZT, 3TCNoneK219QK101H, G190AV35T, T39E, S48T, V60I, K173A, Q174K, D177E, V179I, T200A, Q207E, R211K, V245QC
 251210.ZA.GT1195KC423034AZT, DDINoneD67N, K70R, K219QK103N, P225HK22R, V35T, E36A, T39E, S48T, V60I, D121H, K122E, D123S, A158S, K173A, Q174K, D177E, T200A, Q207E, R211K, F214FL, L228LH, V245Q, D250EC
 111808.ZA.EC010KC423322AZT, DDINoneM41L, D67N, K70R, V75M, L210W, T215F, K219QA98G, K101EE28K, K32I, V35T, T39E, V60I, K122E, D123DG, I135V, S162C, K173A, Q174K, D177E, I178L, G196GE, T200A, K201KR, E203A, Q207E, H208Y, R211K, L228H, V245QC
 115211.ZA.NL004KC423718AZT, 3TC, DDINoneD67N, K70R, M184V, K219QA98G, K101EK20R, V35T, T39E, S48T, V60I, K122E, D123N, I135V, E138A, S162C, K173T, Q174KR, V179I, G196E, T200A, Q207K, R211T, D237N, V245QC
 224810.ZA.GT1436KC423227AZT, DDINoneM41ML, D67N, K70R, T215F, K219QK101KEV35T, T39E, S48ST, V60VI, E89EG, K122E, D123N, I135IL, E138A, K173A, D177E, I178L, T200A, Q207D, R211K, V245Q, E248DC
 523810.ZA.WC103KC423245AZT, DDINoneD67N, K70R, T215I, K219Q V35T, T39E, S48T, E53D, K122E, D123G, E138A, K166R, K173A, E194A, Q197P, T200A, Q207D, R211K, F214L, V245QC
 173108.ZA.GT494KC423690AZT, DDINoneD67N, V75VM, M184V, K219QK103N, P225H, K238TV35T, T39E, S48T, V60I, K122E, K173A, Q174K, D177E, I178L, T200A, Q207D, R211K, V245QC
Acharya (2014)DGP175DGP175KJ185345TDF, 3TCNoneM41L, D67N, K70R, L74I, M184V, T215Y, K219QA98G, K103NV35T, T39D, E44D, S48T, V60I, K101R, V118I, D121Y, K122E, S162A, K173T, Q174K, D177E, I178M, T200A, E204A, Q207D, R211K, V245Q, A272P, K277R, T286A, E291D, V292IC
 DGP162DGP162KJ185332TDF, 3TCNoneM41L, D67N, T69D, K70R, L74I, M184V, T215F, K219QY181I, G190SV35T, T39D, S48T, V60I, D121H, K122E, K173A, Q174R, D177E, I178L, Q197K, T200A, Q207E, R211K, V245Q, A272P, K277R, E291D, V292I, I293V, P294TC
 DGP121DGP121KJ185291AZT, 3TCNoneM41L, D67N, K70R, V75M, T215F, K219QV106M, V108I, G190AV35T, E36A, T39E, S48T, V60I, T69N, K101R, K122E, I135T, S162A, K166R, K173A, D177E, G196R, T200A, Q207A, V245Q, A272P, K277R, E291D, V292I, I293VC
Steegen (2014)10ZAKS03810ZAKS038KJ176320D4T, 3TCNoneM41L, D67N, K70R, L74I, M184V, K219Q V35T, T39E, S48T, E53D, K122E, I135T, S162A, K173T, Q174K, V179I, T200A, Q207E, R211KT, F214L, P243PT, V245Q, A272P, K275R, Q278H, K281R, T286A, E291D, V292I, I293V, P294TC
Neogi (2016)711413.ZA.EC517KT592727TDF, 3TCNoneD67G, T69D, K70R, M184V, K219QL100I, K103NK20R, V35T, T39E, V60I, V106VL, K122E, D123G, I135V, T139Q, I142T, K173A, D177G, V179N, T200A, E203K, Q207E, L228H, V245QC
 91413.ZA.WC348KT593534ABC, 3TCNoneM41L, D67N, K70R, L74V, K219QL100I, K103N, P225HP14S, V35T, E36A, T39E, S48T, T69TN, V90I, K173A, Q174K, D177E, T200A, Q207K, D218DE, V245KC
 409313.ZA.GT2842KT593178AZT, DDINoneD67N, K70R, M184V, K219Q E28EK, V35T, T39E, S48T, V60I, K101A, K122E, I135T, K173T, Q174R, D177E, T200A, Q207E, R211K, F214L, D218E, L228LH, V245E, D250EC
 14913.ZA.NL074KT593447TDF, 3TCNoneT215TI, K219QY181YCP4S, P14AT, K20R, V21I, V35T, E36A, T39E, S48T, P55L, Y115C, K122E, D123S, S162Y, K166KR, K173A, Q174K, D177E, T200A, I202V, Q207E, R211K, F214L, V245Q, D250EC