<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype C
Gene RT
Mutation K219E
Rx >= 1 NRTI
(but no NNRTI)
IncludeMixtures No
References 9
Patients 34
Isolates 36
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Pillay (2008)DR15DR15AY589875AZT, DDINoneD67N, K70R, K219E K20R, V35T, T39K, S48T, V60I, V118I, K122E, D123N, A158S, S162G, K173T, Q174A, T200A, E203EK, Q207E, R211K, F214L, V245Q, D250E, S251D, A272P, K277R, Q278E, E291D, V292I, I293V, E297KC
Deshpande (2009)Pat24814artFJ530693AZT, 3TCNoneD67N, K70R, M184V, T215F, K219EA98AGV35T, T39E, S48T, V60I, T69N, V118I, D121H, K122E, I135T, K173AT, D177E, I178M, T200A, E204K, Q207E, F214L, E224D, V245QC
 Pat119217RTFJ530822D4T, 3TCNoneM184MV, K219EK103N, Y181YCT7S, V35T, T39D, V60I, W88C, D121H, K122E, I135V, K173A, D177E, D192DY, T200A, I202V, E204K, Q207E, F214FL, L228LRC
 Pat044327FJ530897AZT, 3TCNoneM41ML, D67N, K70R, V75M, M184AV, T215F, K219EG190AL12I, V35T, T39N, V60I, T69TN, D121HY, K122E, I135M, S162SN, K173A, D177E, V179I, E203EV, Q207E, L228H, V245QC
 Pat043329FJ530898AZT, 3TCNoneM41L, D67N, K70R, V75M, M184V, T215F, K219EG190AV35T, T39N, V60I, D121H, K122E, I135M, K173T, D177E, V179I, Q207E, L228H, V245QC
 Pat042336FJ530899AZT, 3TCNoneD67N, K70R, M184V, T215FI, K219EK103KN, Y181YC, G190A, K238KTT27TS, V35T, T39D, E40ED, V60I, L109I, D121H, K122E, I135T, K166R, K173T, Q174R, D177E, T200A, I202V, Q207E, R211K, L228H, V245QC
Sigaloff (2011)HIV100264HIV100264JN132225ABC, TDF, 3TCNoneD67N, K70R, M184V, T215Y, K219EV106M, Y181C, F227LS3C, V21I, V35T, E36A, T39E, S48T, K122E, D123S, S162C, K173A, D177E, T200A, I202IV, E203EK, Q207E, L210LS, H221Y, V245Q, A272K, T286A, E291D, V292I, I293VC
Van Zyl (2013)45011.ZA.WC191KC423708TDF, 3TCNoneD67DN, M184V, T215TFIS, K219EY181YCE6D, K20R, V35IT, E36A, T39D, S48T, K122E, D123N, T139A, S162SCT, K166R, Q174N, G196GE, T200E, E203EK, Q207E, R211K, V245QC
 406911.ZA.GT2008KC423750AZT, 3TCNoneK65R, M184V, K219EL100I, K103NV35T, E36A, T39E, V60I, S68G, K122E, D123S, T139V, K173A, D177E, V179VI, T200A, E203K, Q207A, R211K, D218E, V245QC
 175611.ZA.GT1646KC423440AZT, DDINoneD67N, K70R, K219E V35T, T39N, S48T, V60I, K103R, K122E, K173T, Q174R, T200A, Q207A, R211K, F214L, V245Q, D250EC
 26012.ZA.NL010KC423765AZT, 3TCNoneD67N, K70R, M184V, T215F, K219EA98G, K101E, Y181CV35T, E36A, T39E, S48T, V60I, K122E, D123S, T139R, E169A, K173A, Q174E, T200A, E203K, Q207E, F214L, V245KC
 280909.ZA.GT932KC424424D4T, 3TCNoneD67N, K70R, M184V, K219E V35T, E36A, T39E, K122E, D123T, I135T, S162CY, K173T, Q174K, D177G, T200A, Q207A, R211K, V245QC
  10.ZA.GT1191KC423030D4T, 3TC, ABCNoneD67N, K70R, Q151M, M184V, T215TI, K219E E6EK, V35T, E36A, T39E, K122E, D123T, I135T, S162Y, K173T, Q174K, D177G, T200A, Q207A, R211K, V245QC
 18012.ZA.NL024KC423856AZT, 3TCNoneD67DN, K70R, M184V, T215TI, K219EL100LI, K103N, Y181CV35T, T39E, K101KR, K122E, I135V, S162ST, K173T, T200A, E203EK, Q207E, R211K, D218DE, V245QC
Acharya (2014)DGP089DGP089KJ185259TDF, 3TCNoneM41L, D67N, K70R, V75M, M184V, T215F, K219EY188LV35T, E36A, T39E, S48T, V60I, K122E, D123S, I135T, K166R, K173A, D177E, T200A, Q207E, R211K, V245Q, A272P, K277R, K281R, E291D, V292I, I293VC
Steegen (2014)11ZAKS09011ZAKS090KJ176372ABC, 3TCNoneM41L, M184V, K219E V35T, E36A, T39E, S48T, V60I, K122E, D123G, T139A, K166R, K173T, D177E, V179VI, Q207E, R211K, V245K, A272P, K277R, T286A, E291D, V292I, I293V, E308EKC
 12ZAKS20412ZAKS204KJ176484ABC, 3TCNoneD67N, K70R, M184V, K219EY181CE6K, V35T, E36A, T39E, S48T, V60I, K122E, S162C, K173A, D177E, T200A, Q207N, R211K, H221Y, V245Q, A272P, Q278H, K281R, E291D, V292I, S322T, Q334D, G335DC
Chimukangara (2016)NC15NC15KU508560TDF, FTC, 3TCNoneD67N, T69D, K70R, M184V, T215F, K219EK103S, Y181C, G190AV35K, E36A, T39E, S48T, V60I, K102R, V118I, K122E, D123G, S162N, K173T, D177E, V179I, T200A, I202V, R206K, Q207E, R211K, F214L, L228HC
Neogi (2016)714313.ZA.EC707KT592854D4T, 3TCNoneD67N, K70R, M184V, L210LW, T215F, K219EY188LI2V, V8I, V35K, T39E, S48T, V60I, T69N, A98S, V118VI, D121H, K122E, K173T, Q174K, D177E, V179VI, T200E, E203K, Q207E, H208HY, D218E, V245QC
 106513.ZA.EC558KT592756AZT, DDINoneD67N, K70R, K219EY188LV35T, E36A, T39E, S48T, V60I, T69S, K122E, D123S, K173T, D177G, I180IV, T200A, E203K, Q207E, V245QC
 353913.ZA.GT2917KT593229AZT, 3TC, DDINoneD67DN, K70R, M184V, K219EG190AV35T, T39E, S48T, K122E, D123G, K173A, Q174K, D177E, I178M, T200A, E203K, E204D, Q207D, R211K, V245Q, D250EC
 18013.ZA.NL089KT593460AZT, 3TCNoneD67N, K70R, M184V, T215I, K219EK103N, Y181CV35T, T39E, K101R, K122E, I135V, K173T, V189VI, T200A, Q207E, R211K, V245QC
Posada Cespedes (2017)129615.ZA.EC1676 TDF, 3TCNoneM41L, D67N, T69DN, K70R, M184V, T215Y, K219EA98GV35T, T39N, V60VI, S68G, K122E, D123N, K173A, Q174R, D177E, E194K, G196E, T200A, E203D, Q207E, R211K, V245QC
 158815.ZA.GT4457 AZT, 3TCNoneK65R, D67N, K219EK101E, V106M, Y181C, G190AE6K, V8I, K20R, V35T, E36A, T39E, S48T, V60I, S68G, K122E, D123S, A158S, T165I, K173A, Q174K, D177E, T200A, I202IV, Q207E, R211K, V245QC
 235714.ZA.GT3233KX544140TDF, 3TCNoneD67N, K70R, M184V, T215F, K219EK103N, V108VIK20R, V35T, E36A, T39E, S48T, V60I, W88C, V90I, K102M, K122E, T165L, K166R, K173A, Q174R, D177E, T200A, I202V, Q207E, R211K, F214L, I244V, V245QC
 11312.ZA.EC470KX541921ABC, 3TCNoneK70KR, L74V, M184V, K219EK103N, Y181CK20R, V35T, E36A, T39E, S48T, V60I, K122E, D123S, T139A, I142V, S162H, K173A, Q174K, D177E, T200A, Q207A, R211K, F214L, V245Q, D250EC
 413412.ZA.GT2373KX542200AZT, 3TCNoneD67N, T69D, K70R, T215F, K219EK103N, V106M, Y181C, F227LK20R, E28*K, V35T, E36A, C38*, T39E, S48T, V60I, K122E, D123S, E138A, P157A, K173A, Q174R, D177E, T200A, I202V, E203A, Q207A, R211K, F214L, K223N, L228R, V245QC
 25613.ZA.NL091 AZT, 3TCNoneD67N, K70R, M184V, K219E V35T, E36A, T39E, V118I, K122E, D123S, K173T, Q174K, D177DE, T200A, Q207E, F214L, E248DC
 508615.ZA.GT4197 TDF, 3TCNoneD67G, K70R, M184V, K219E K32Q, V35K, E36A, T39E, S48T, S68G, K122E, D123S, I135T, S162F, K173A, D177E, G196K, T200A, Q207K, R211K, F214L, V245QC
 57614.ZA.EC1203KX543822TDF, 3TCNoneK65R, M184V, K219EK103KN, G190AV35T, E36A, T39E, S48T, K64R, S68K, K102N, K122E, D123S, S162C, K173KAET, Q174QK, D177E, I178IM, T200A, Q207D, R211K, F214L, V245Q, E248DC
 129915.ZA.EC1691 D4T, 3TCNoneD67G, K70R, M184V, K219E K43R, E44Q, G45X, K46X, I47X, E53D, V60I, S68G, K122E, D123GS, I135V, A158S, S163T, K173A, Q174K, D177E, I178M, V179T, T200A, Q207D, R211K, V245QC
 514915.ZA.GT4260 AZT, 3TCNoneD67N, K70R, M184V, K219E V35T, T39K, K49R, K122E, D123GS, I142V, A158S, S162A, K173A, D177E, I178L, T200A, K201R, E204Q, Q207A, R211K, F214L, V245Q, P247AC
 493615.ZA.GT4042 TDF, AZT, 3TCNoneD67T, T69G, K70R, M184V, T215I, K219EV106M, Y188L, P225HV8I, V21I, V35T, E36A, T39E, V60I, K102R, G112A, K122E, D123S, K173A, Q174K, D177E, V179I, T200A, I202IV, Q207E, R211K, V245H, D250EC
 573314.ZA.WC559 AZT, 3TCNoneD67N, K70R, M184V, T215IV, K219EK101E, V108I, Y181C, G190A, K238TE28K, V35T, T39E, T69TN, V90I, K122E, D123DGNS, K173A, Q174K, D177E, T200A, Q207E, R211K, L228H, V245QC
 328413.ZA.GT2987KX543282AZT, DDI, D4T, 3TC, TDFNoneD67G, K70R, M184V, K219E E6D, V35T, T39E, T69N, W88C, V118I, K122E, D123N, I135T, E138G, A158S, K173T, Q174K, V179IT, T200E, I202V, E203K, R211K, F214LC
 198614.ZA.GT3362 TDF, 3TCNoneD67N, K70R, M184V, K219EK103N, P225HV8I, K20R, K32R, V35T, T39E, S48T, V60I, K122E, D123G, K173A, Q174K, D177E, T200A, Q207A, R211K, V245Q, D250EC