<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype C
Gene RT
Mutation V118I
Rx >= 1 NRTI
(but no NNRTI)
IncludeMixtures No
References 18
Patients 65
Isolates 66
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Gonzales (2001)CA4490CA10973AF331685AZT, 3TCNone  P4S, E28K, K32E, V35K, E36A, T39E, S48T, V60VI, V118I, K122E, D123N, F124FV, Y127YD, I142M, K173A, Q174K, T200A, Q207E, R211K, F214L, T240TA, V245QC
Gibb (2002)DMG9595_w75 ABC, 3TCNoneL74V, Y115F, M184VV179VDV35T, T39E, S48T, V118I, K122E, D123N, E138A, I142V, K173I, Q174K, P176PS, T200E, Q207K, R211K, F214L, V245Q, E248D, K249Q, A272P, K275R, K277R, Q278H, E291D, V292I, I293V, P294E, D324E, I329L, Q334H, G335D, R356K, M357T, G359T, T369A, A376T, T377R, K390R, E396D, T397IC
Weber (2003)85H610185H-48AY140823NRTI, AZT, 3TCNoneM41L, D67N, M184V, L210W, T215Y V35T, T39E, S48T, A98S, V118I, K122E, D123N, I135T, K173T, Q174K, N175Y, G196E, T200A, Q207N, R211K, V245Q, A272Q, E291D, V292I, I293VC
Non-B Workgroup (2005)UK1411bUK1411bAY901378AZT, DDINoneM41MIL, D67GS, T215Y K20R, T39E, E40ED, E44ED, S48ST, T69S, V118I, K122E, D123N, K173A, D177E, T200A, Q207E, R211KC
 SA81_DR26SA81_DR26AY901714D4T, DDINoneA62V, K65R, V75T I2V, V35T, T39E, S48T, E53D, S68G, V118I, K122E, D123S, I135T, E138A, E169ED, K173AT, Q174K, I178M, T200A, Q207E, R211RK, F214L, K219G, V245VE, D250E, K263KN, A272P, K277R, L283I, T286A, E291D, V292I, I293V, V317AC
 TK3015TK3015 AZT, 3TC, DDCNoneM41L, D67N, L210W, T215Y V35M, T39D, E44D, V118I, K122E, I135L, K173A, Q174K, N175Y, D177E, V179A, E194K, G196E, T200A, I202V, Q207E, R211K, V245Q, D250E, I257V, A272S, T286A, K287X, E291D, V292I, I293V, H315FC
 TK3032TK3032 AZT, 3TC, D4TNoneM41L, M184V, T215FV179DV8I, K20R, V35T, E36A, T39E, S48T, V118I, K122E, D123N, I135T, S162T, E169Q, K173T, Q174K, T200A, Q207E, R211K, F214L, P243T, V245Q, E248D, A272P, K275R, K277R, Q278H, T286A, E291D, V292I, I293V, D324E, I329LC
Weber (2005)F56949F56949AY677552DDC, AZT, D4T, DDI, TDFNoneM41L, D67N, L210W, T215Y V21I, V35T, E36A, T39E, S48T, V118I, K122E, D123G, K173A, D177E, T200A, Q207E, R211K, V245Q, A272P, I274V, Q278H, K281R, T286A, E291D, V292I, I293V, K311RC
Rey (2006)H3117DR_H3117 TDF, AZT, 3TCNoneA62AV, K65R, K70KT, Y115YF, M184MV V35L, E36N, I37F, T39E, S48T, S68R, V118I, T139A, K166R, K173T, D177E, T200E, Q207E, R211K, F214L, L228LR, V245TC
Pillay (2008)DR15DR15AY589875AZT, DDINoneD67N, K70R, K219E K20R, V35T, T39K, S48T, V60I, V118I, K122E, D123N, A158S, S162G, K173T, Q174A, T200A, E203EK, Q207E, R211K, F214L, V245Q, D250E, S251D, A272P, K277R, Q278E, E291D, V292I, I293V, E297KC
 DR60DR60AY589912AZT, D4T, DDINoneM41L, D67N, L210W, T215Y P4T, K20R, T27S, V35T, T39E, S48T, V60I, V118I, K122E, D123S, E138A, K173T, Q174K, T200A, Q207E, R211K, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, P294PQC
 DR2602ZA.DR26AY589883D4T, DDINoneA62V, K65R, V75T I2V, V35T, T39E, S48T, E53D, S68G, V118I, K122E, D123S, I135T, E138A, E169ED, K173AT, Q174K, I178M, T200A, Q207E, R211RK, F214L, K219G, V245VE, D250E, K263KN, A272P, K277R, L283I, T286A, E291D, V292I, I293V, V317AC
 DR8103ZA.DR81AY589925D4T, DDINoneM41L, D67N, T215Y K11Q, V35T, T39E, S48T, V60I, K101Q, V118I, D121Y, K122E, D123G, I142V, S162C, K166R, K173A, D177E, T200A, Q207E, R211KC
 DR8803ZA.DR88AY589928D4T, DDINoneM41L, D67N, L210W, T215Y V35T, T39E, S48T, V60I, F77FS, G93GR, K101T, F116FL, V118I, S134I, K173A, D177E, T200A, Q207E, R211K, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, V317AC
Deshpande (2009)Pat24814artFJ530693AZT, 3TCNoneD67N, K70R, M184V, T215F, K219EA98AGV35T, T39E, S48T, V60I, T69N, V118I, D121H, K122E, I135T, K173AT, D177E, I178M, T200A, E204K, Q207E, F214L, E224D, V245QC
 Pat20920RTFJ530732D4T, 3TC, AZTNoneM41L, D67N, L74IV, M184V, L210W, T215Y, K219KNA98G, K101E, V108I, Y181CFGVK20R, K32T, V35K, T39D, E44D, S48T, V60I, V118I, D121Y, K122E, I135R, S162A, K173ST, V189I, T200A, E203V, Q207E, R211K, K223Q, T240K, V245QC
Kassaye (2009)TCDD-23TC23_2003FJ445712DDC, AZTNoneD67G, T69T_T, K70R, K219Q V35T, T39E, S48T, V60I, K64N, K103KR, V118I, K122E, D123S, E138A, T139A, K173T, Q174K, T200A, I202V, E203K, Q207E, R211K, F214L, D218E, L228HR, V245E, E248DC
Ndembi (2010)15213D_P115213GQ409573ABC, AZT, 3TCNoneM184V E6D, K30N, V35T, E36A, T39K, S48T, V118I, K122E, D123N, K173A, Q174K, D177E, I178V, Q197K, T200A, Q207E, F214L, L228MC
 DT3548_05_P13548GQ409622ABC, AZT, 3TC, D4TNoneY115F, M184V V35T, E36A, T39E, E40D, S48T, E53D, V118I, K122E, K173A, Q174K, T200A, Q207N, R211K, F214L, L228QC
Rodrigues (2010)301_07BR07SC301GQ4013143TCNoneM41L, D67N, T69D, M184V, L210W, T215C I5V, V35T, E36A, T39D, K43R, E44D, V118I, K122E, D123S, I135T, K173T, D177E, T200A, E203D, Q207E, H208Y, R211KC
Van Zyl (2013)369210.ZA.GT1140KC422976D4T, 3TCNone  K22KR, V35T, E36A, T39E, S48T, V118I, K122E, D123G, A158S, K173A, D177E, T200A, Q207E, R211KC
 342810.ZA.GT1108KC422948D4T, 3TCNoneT215PK103NV35T, E36A, T39E, S48T, V60I, V118I, D123E, E138D, K173A, Q174K, D177E, I178M, T200A, Q207D, R211K, F214LC
 152311.ZA.GT1849KC423630AZT, 3TC, DDINoneM184V, K219QK101E, K103N, G190AT27S, E29G, V35T, E36A, T39E, V60I, S105T, V118I, I135T, E138A, I142V, K173L, Q174K, V189VI, T200A, R211K, F214L, V245QC
 54811.ZA.EC064KC423577AZT, 3TCNoneM184VV179DK20R, V35T, E36A, T39E, S48T, W88C, K102R, K103R, V118I, K122E, D123N, I135L, E138A, T139A, S162C, Q174K, T200A, Q207E, R211I, F214LC
 192711.ZA.GT1575KC423361AZT, DDINone V106VIM, V179DK20KR, V35T, E36A, T39E, E40D, K103R, V118I, K122E, D123N, I135R, A158S, K173T, T200A, Q207G, F214L, D250EC
 357208.ZA.GT600KC424000D4T, 3TCNoneM184V V35T, E36A, T39E, S48T, D86E, W88S, V118I, K122E, D123DN, I135T, E138A, K173T, Q174R, T200A, Q207E, R211K, F214L, V245Q, P247A, E248DC
 348209.ZA.GT821KC424323D4T, 3TCNoneM184V V35T, E36A, T39E, S48T, V60I, K104R, V118I, K122E, D123S, T165I, K166R, K173A, Q174K, D177E, T200A, Q207E, R211K, F214L, V245Q, D250EC
 306907.ZA.GT096KC424150AZT, DDINone  V35T, T39E, S48T, V60I, V118I, K122E, D123N, I135T, E138A, K173T, Q174R, T200A, Q207E, R211Q, F214L, V245Q, E248D, A272P, K275R, Q278H, T286A, E291D, V292I, I293V, I329L, G335DC
  07.ZA.GT188KC424037AZT, DDINone  V35T, T39E, S48T, V60I, V118I, K122E, D123N, I135T, E138A, K173T, Q174R, T200A, Q207E, R211Q, F214L, V245Q, E248DC
Acharya (2014)DGP175DGP175KJ185345TDF, 3TCNoneM41L, D67N, K70R, L74I, M184V, T215Y, K219QA98G, K103NV35T, T39D, E44D, S48T, V60I, K101R, V118I, D121Y, K122E, S162A, K173T, Q174K, D177E, I178M, T200A, E204A, Q207D, R211K, V245Q, A272P, K277R, T286A, E291D, V292IC
 DGP165DGP165KJ185335TDF, 3TCNoneM41L, D67N, M184V, T215YK103N, Y188LV35T, T39N, S48T, E53D, V60I, V118I, D121Y, K122E, S162A, K173A, D177E, V179T, T200A, Q207E, L210S, H221Y, V245Q, A272P, K277R, T286A, I293VC
Steegen (2014)11ZAKS16211ZAKS162KJ176444D4T, 3TCNoneA62AV, V75T, M184VK103N, V108II31L, V35I, T39KN, S48T, E53D, V118I, K122E, D123G, K173T, Q174K, D177EG, T200A, I202V, Q207A, R211K, H221Y, V245Q, A272P, E291D, V292I, I293V, I309X, K311R, D324EC
 12ZAKS33212ZAKS332KJ176611ABC, 3TCNone  V35T, T39E, E40D, S48T, K82KR, A98S, V118I, K122E, I135R, K173AT, Q174K, D177E, V179I, T200A, I202V, Q207E, R211K, F214L, V245Q, A272P, K281R, T286A, I293V, G333S, Q334DE, I341IV, R356K, G359T, T377Q, K390R, A400L, E404DC
 12ZAKS25112ZAKS251KJ176530D4T, 3TCNoneM184V K20R, V35T, E36A, T39E, S48T, V60I, K104R, V118I, K122E, D123S, I135T, E138A, K173T, Q174K, T200K, Q207E, F214L, V245Q, E248D, A272P, K275R, K277R, Q278H, T286A, E291D, V292T, I293V, P313S, V317A, I329V, Q334H, G335D, R356K, G359T, A371V, S379G, T386I, K390R, A400T, E404DC
 12ZAKS24712ZAKS247KJ176526D4T, 3TCNone V179DE6N, V35T, T39E, S48T, V118I, K122E, D123N, E138A, T139V, K173T, Q174K, D177N, T200E, Q207K, R211E, F214L, V245Q, E248D, A272P, G273R, K275R, Q278Y, K281R, E291D, V292I, I293V, A304E, P313T, Q334N, G335D, Y342F, Q343KC
Rossouw (2015)RP077RP077KT032022D4T, 3TCNone  V35T, E36A, T39E, S48T, V60I, V118I, D121H, K122E, K173A, Q174K, D177E, T200A, Q207E, R211K, F214L, V245Q, E248D, A272P, K277R, T286A, E291D, V292I, I293V, Q334H, G335D, R356K, G359T, T377L, T386A, K390R, E396D, A400AT, I434V, V435AC
Chimukangara (2016)NC15NC15KU508560TDF, FTC, 3TCNoneD67N, T69D, K70R, M184V, T215F, K219EK103S, Y181C, G190AV35K, E36A, T39E, S48T, V60I, K102R, V118I, K122E, D123G, S162N, K173T, D177E, V179I, T200A, I202V, R206K, Q207E, R211K, F214L, L228HC
Neogi (2016)86913.ZA.WC351KT593537TDF, AZT, 3TCNoneM41L, A62V, V75I, M184V, T215YA98G, V106M, Y188F, F227LI31L, V35I, T39E, K43R, E44D, S48T, L109I, V118I, D121HY, K122E, I135L, I142IV, S162A, K173T, D177E, V189I, T200A, I202V, Q207E, L210T, R211K, D218E, H221Y, V245QC
 43313.ZA.WC301KT593501TDF, 3TCNoneV75I, M184VV106M, V179DP4H, I31L, V35T, T39E, I47L, S48T, V118I, K122E, D123N, K126Q, I132L, S162C, I180L, T200A, Q207E, R211G, F214L, V245TC
Posada Cespedes (2017)14712.ZA.NC003KX542397AZT, DDINoneM41L, D67N, K70R, V75M, T215Y E6K, K20R, V35T, T39E, E44D, S48T, V60I, K103R, V111VI, V118I, K122E, I135T, T139TA, K173V, Q174K, N175Y, D177E, V179T, G196E, T200A, Q207D, H208Y, R211K, D218E, V245QC
 219315.ZA.GT4406 AZT, 3TC, DDINoneD67DN, M184VK101E, V106M, G190AK20R, V35T, T39E, S48T, V118I, K122E, I135T, E138A, S163C, T165I, K173T, Q174K, D177E, T200S, I202V, R211K, F214L, K238KQC
 74814.ZA.WC521KX544772AZT, 3TCNone  P4S, E6KT, T7TP, V35T, T39E, S48T, V118I, K122E, K173A, Q174K, T200A, Q207E, R211K, F214L, V245Q, D250EC
 449615.ZA.EC1623 AZT, 3TCNoneD67N, K70R, M184VV106AP4S, K20R, T27S, V35T, T39E, S48T, K49R, V60I, V118I, K122E, D123S, I135T, E138A, E169A, K173A, Q174A, D177E, T200A, I202V, R211K, F214LC
 251709.ZA.GT706KX540200AZT, DDINone G190EP4H, V35T, T39E, S48T, D76DN, D86DN, W88C, V118I, D121DN, K122E, D123S, E138A, T139AP, S162SC, K173A, Q174K, T200A, Q207E, R211K, F214LC
 470414.ZA.GT3798 AZT, 3TCNoneM184V K22R, V35T, T39K, S48T, V118I, K122E, D123N, I135T, E169Q, K173T, Q174R, T200A, I202V, Q207G, R211K, F214L, V245Q, D250EC
 101114.ZA.WC496KX544754AZT, 3TCNone  V35T, T39E, S48T, V60I, V118I, K122E, D123S, I135T, E138A, T139A, K173A, D177G, T200A, Q207E, R211K, F214L, K238KE, V245QC
 33113.ZA.EC754KX542780ABC, 3TCNoneL74V, Y115F, M184V I2V, V35R, T39A, S48T, V118I, K122E, D123DG, T165I, T200A, R211K, F214LC
 574515.ZA.EC1620 AZT, 3TCNone  K20R, V35T, T39E, S48T, V60I, V118I, K122E, D123S, T165IV, K173A, Q174S, D177E, G196E, T200A, I202V, Q207E, R211K, F214L, L228R, V245QC
 93314.ZA.WC441KX544703D4T, 3TCNoneM184V P4S, V35T, S48T, V60I, V118I, K122A, D123S, T139S, K173T, Q174K, T200A, Q207K, R211A, F214L, V245KC
 25613.ZA.NL091 AZT, 3TCNoneD67N, K70R, M184V, K219E V35T, E36A, T39E, V118I, K122E, D123S, K173T, Q174K, D177DE, T200A, Q207E, F214L, E248DC
 32412.ZA.WC278KX542541ABC, 3TCNoneL74V, M184V V35T, T39E, S48T, V60I, V118I, K122E, D123S, I135T, E138A, K173T, Q174K, I195L, T200A, Q207E, H208HY, R211K, F214L, V245QC
 57314.ZA.EC1425KX544019AZT, 3TCNoneM41L, D67N, L210W, T215Y, K219KR K20R, V35T, T39E, E44D, V111VIM, V118I, K122E, D123S, I142T, K173A, D177E, I178L, T200A, K201R, E203D, E204K, Q207D, H208Y, R211K, W212M, D218E, H221Y, V245Q, E248TC
 95014.ZA.WC398KX544671ABC, 3TCNoneL74V, Y115F, M184VK103NV35T, E36A, T39E, S48T, K49R, V118I, K122E, S162N, T165I, K173T, Q174K, D177E, T200A, Q207AC
 570314.ZA.EC1286KX543895AZT, 3TCNoneM41L, M184V, T215FK101H, K103N, G190AV35T, T39E, E53D, V118I, K122E, D123N, T139S, I142V, Q174K, N175Y, D177N, T200A, Q207E, F214L, V245QC
 313606.ZA.GT015KX539561AZT, 3TCNoneK65R, K70R, V75I, F77L, F116Y, Q151MK103N, V106MV21I, K32I, V35T, T39K, S48T, K64KQ, S68G, V118I, K122E, D123S, T139A, I142T, T165I, Q182H, G196E, T200A, Q207E, F214L, L228Q, A272P, Q278H, T286A, E291D, V292I, I293VC
 454514.ZA.WC533KX544784AZT, 3TCNoneM184VA98G, K103NE28A, V35T, T39E, S48T, V60I, V106VL, V118I, K122E, I135T, K173A, D177E, I178M, T200A, Q207K, R211KT, F214L, V245Q, E248DC
 64914.ZA.EC1312KX543919TDF, AZTNoneM184VK101H, V106M, V179DK20R, V35T, E36A, T39E, S48T, V60I, V90I, V118I, K122E, D123N, I142Q, T165L, K173A, Q174R, D177E, T200A, I202V, Q207E, R211RK, F214L, V245L, E248D, Q258HC
 419314.ZA.GT3578KX544413TDF, 3TCNoneD67N, T69D, M184V, T215FA98G, K103N, Y181CK20R, V35T, T39E, V118I, K122E, D123S, I135T, K173A, T200E, E203D, E204Q, Q207A, R211K, L228LH, V245Q, E248DC
 129815.ZA.EC1686 AZT, 3TCNoneA62V, V75I, F77L, F116Y, Q151M, M184V K20R, V35T, E36A, T39E, S68K, W88C, I94L, K102Q, V118I, K122E, D123S, K173A, Q174K, D177E, I178L, G196E, T200A, Q207EC
 268308.ZA.GT549KX540010D4T, DDINoneD67N, T215F K11H, I31L, V35T, T39N, S48T, V60I, V118I, D121Y, K122E, G152GE, S162Y, K173A, Q174K, D177E, I178L, T200A, Q207E, R211K, V245QC
 455515.ZA.GT3960 AZT, 3TCNone  V35T, E36A, T39K, K43E, S48T, V60I, V118I, K122E, D123G, E138A, K173V, Q174K, D177E, I178V, V179I, T200E, Q207E, R211K, F214L, V245QC
 75113.ZA.WC340KX543607D4T, 3TCNoneM184V K20R, V35T, E36A, T39K, K43E, S48T, V60I, V118I, K122E, I135V, S163T, T165TAIV, K173A, Q174K, D177E, E194D, T200A, Q207E, R211K, F214L, V245Q, E248DC
 249112.ZA.GT2175KX542041AZT, 3TCNone  P4S, V35M, T39E, S48T, E53D, V118I, K122E, D123N, K166R, K173T, Q174K, D177E, T200A, Q207E, R211K, W212W*, F214L, V245LQC
 716914.ZA.WC403KX544676D4T, 3TCNoneM184V V35T, T39E, S48T, V60I, V118I, K122E, D123S, I135T, E138A, T139A, T165I, K173A, D177EG, T200A, Q207EC
 328413.ZA.GT2987KX543282AZT, DDI, D4T, 3TC, TDFNoneD67G, K70R, M184V, K219E E6D, V35T, T39E, T69N, W88C, V118I, K122E, D123N, I135T, E138G, A158S, K173T, Q174K, V179IT, T200E, I202V, E203K, R211K, F214LC
 32012.ZA.WC239KX542508D4T, 3TCNoneM184V P4PS, E6D, V35T, T39E, S48T, V60I, V118I, K122E, D123S, I135T, E138A, K173T, Q174K, I195L, T200A, Q207E, R211K, F214L, V245QC