Reverse Transcriptase Inhibitors

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Reverse Transcriptase Inhibitors

Subtype	B
Gene	RT
Mutation	F77L
Rx	>= 1 NRTI (but no NNRTI)
IncludeMixtures	No

References	33
Patients	47
Isolates	62

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	NRTIs	NNRTIs	NRTIDRMs	NNRTIDRMs	OtherMut	Subtype
Shafer (1995)	JIDP26	JIDP26W88	AF021308	AZT, DDI	None	A62V, V75I, F77L, F116Y, Q151M, K219E		T39A, S68G, A98S, I135V, R172K, Q174H, R211G, F214L, V245M	B
	JIDP25	JIDP25W104	AF021296	AZT, DDI	None	V75I, F77L, Y115F, F116Y, Q151M, K219E		V35E, E36K, I37X, S48T, S68G, K122E, I142T, R211K	B
	CA478	CA899	AF021299	AZT, DDI	None	F77L, F116Y, Q151M		V35I, R83K, A158S, R211K, V245E	B
Ruiz (1996)	JCS-C13	C13B	Z99306	AZT, DDI	None	K65R, V75I, F77L, F116Y, Q151M		V35M, T39K, K43E, S68G, T69I, K70X, K102Q, K122E, K166R, T200A, R211G, V245E, D250E	B
		C13W24	Z99307	AZT, DDI, 3TC	None	K65R, V75I, F77L, F116Y, Q151M, M184V		V35M, T39K, K43E, S68G, T69I, K70X, K102Q, K122E, K166R, T200A, R211G, V245E, D250E	B
Cabana (1999)	Cab-b	B58	AF102335	DDC, AZT, 3TC, D4T	None	M41L, D67E, V75M, F77L, M184V, L210W, T215Y		E40F, K43E, S68G, V118I, K122P, D123E, I135T, L149I, S162C, D177E, Q207E, R211K	B
	Cab-l	L0	AF102366	AZT, 3TC, DDI	None	K65R, K70R, V75I, F77L, F116Y, Q151M		T39K, K43E, S68G, T69I, K102Q, K122E, K166R, R211G	B
		L39	AF102367	AZT, 3TC, DDI, D4T	None	K65R, K70R, V75I, F77L, Y115F, F116Y, Q151M, M184V		T39K, K43E, S68G, T69I, K102Q, K122E, K166R, T200A, R211G, L228Q	B
		L47	AF102368	AZT, 3TC, DDI, D4T	None	K65R, K70R, V75I, F77L, Y115F, F116Y, Q151M, M184V, K219Q		K43E, S68G, T69I, K102Q, K122E, K166R, T200A, R211G, L228K	B
Pellegrin (1999)	IP-36	IP36-M12		D4T, DDI	None	F77L, F116Y, Q151M		S3ST, K20R, D123E, I142V, I178L, Q197L, Q207E	B
Venturi (1999)	GV-2	Vent2W24	AF169045	AZT, DDI	None	F77L		V35I, R83K, D123E, Q207E, R211X	B
Zolopa (1999)	CA626	CA3200	AF088111	AZT, DDI, D4T, 3TC	None	D67G, K70G, F77L, F116Y, Q151M, M184V		I31X, S68N, Q207E, F214L, T286A	B
Albrecht (2000)	ACTG303_12	12RT_bl		AZT, DDI	None	A62V, V75I, F77L, F116Y, Q151M		V35VI, S68SG, T69A, R83K, K173R, Q174K, V245E, A272P, I293V, E297A, E302X	B
		12RT_f1		AZT, DDI, 3TC	None	A62V, K65R, K70R, V75I, F77L, F116Y, Q151M, M184V		T7P, V8G, V35VI, S68G, T69A, R83K, D123G, K173R, Q174K, V245E, A272P, I293V, L295T, E297A	B
	ACTG303_1349	1349RT_bl		AZT, DDI	None	M41ML, V75I, F77L, Y115F, F116Y, Q151M, K219E		K20KN, Y56YD, K66KN, S68G, T107P, D123E, S162T, K220KN, V245M	B
		1349RT_f1		AZT, DDI, 3TC	None	A62V, V75I, F77L, Y115F, F116Y, Q151M, M184V, K219E		V35I, S68G, D123E, S162T, V245M, K277R, Q278H, I293V	B
	ACTG303_1934	1934RT_bl		AZT, DDI	None	V75I, F77L, Y115F, F116Y, Q151M		K49R, I50V, S68SG, N81NI, K122E, E169D, T200A, Q207E, R211K, V245VM, E248DN, A272P, K277R, L279X	B
		1934RT_f1		AZT, DDI, 3TC	None	V75I, F77L, Y115F, F116Y, Q151M, M184V		K49R, I50V, S68G, V90I, K122E, E169D, T200A, Q207E, R211K, V245M, E248D, D250DE, A272P, K277R, T286A, A288S, V292I, E297K	B
Balotta (2000)	CB-216	CB-216	AF252070	DDC, AZT, 3TC, DDI	None	M41L, T69D, V75I, F77L		M16V, V35E, E42K, K43N, E44D, T58S	B
	CB-1	CB-1	AF186766	DDC, AZT, 3TC, D4T	None	A62V, V75I, F77L, F116Y, Q151M, M184V, K219Q		W24WG, E40K, K43N, I50IF, E53D, S68G, T107TP, V118I, D121H, K122E, I178L, T200A, I202V, R211T, F214L	B
	CB-2	CB-2	AF186767	AZT, DDI, 3TC, DDC, D4T	None	K65R, K70R, V75I, F77L, F116Y, Q151M		V35I, S68G, R83K, D123E, K166R, D177E, G196E, R211K	B
Baxter (2000)	GART-G87	GART-87		NRTI, AZT, 3TC	None	K65R, K70R, V75I, F77L, Y115F, F116Y, Q151M, M184V, K219E		S68G, K122E, Q174K, D177E, T200A, Q207K, R211A, L234X	B
Coakley (2000)	EC34	EC3480w		D4T, DDI	None	A62V, V75I, F77L, F116Y, Q151M		K122E, I142D, R143W, A158S, I178M, R211G, A272P, T286A, I329V	B
Miller (2000)	MV-168	MV-168wk48		ABC, AZT, 3TC	None	K65R, V75VIL, F77L, Y115F, Q151M, M184V		V35I, S68G, K122E, I135T, G196E, E204D	B
Shulman (2000)	CA624	CA9919	AY802614	DDI, D4T, 3TC, AZT	None	A62V, K70G, V75I, F77L, Y115F, F116Y, Q151M, M184V		S68G, T69K, K122E, K166R, D177E, R211K, K277R, I293V, E297K	B
Albrecht (2001)	ACTG364_1208	1208		DDI, AZT	None	A62V, K70N, V75I, F77L, F116Y, Q151M		E6D, T58N, S68G, D123E, I135T, S162C, D177E, I202V, Q207E, V245E, K277R	B
Eshleman (2001)	A021	AF357625	AF357625	AZT, DDI	None	V75I, F77L, F116Y, Q151M		S68G, T69I, K122E, D123DN, G196E, F214FL, I257IL, V261I, T286A, E297K	B
Gonzales (2001)	CA624	CA1189	AY030418	DDI, D4T, 3TC, AZT	None	A62V, K70G, V75I, F77L, Y115F, F116Y, Q151M, M184EV		S68G, T69N, V148VE, K166KR, D177DE, I178M, Y183Y*	B
	CA1166	CA2649	AY030474	AZT, DDC, D4T, 3TC	None	K65R, K70R, V75I, F77L, Y115F, F116Y, Q151M, K219KE		E6D, V35IM, S68G, K122E, I135T, T200I, I202V, T216TI, V245M, A272P, K275KR, E297D	B
	CA1317	CA3303	AY030517	AZT, DDI, 3TC	None	V75I, F77L, Y115F, F116Y, Q151M, M184V		K46X, K49R, I50V, S68G, K122E, E169ED, T200A, Q207E, R211K, K219T, P243A, V245K, E248D, A272P, K277R, T286A, A288S, V292I, E297K	B
	CA1524	CA4366	AY030643	AZT, DDI, 3TC, D4T	None	M41L, D67N, T69D, V75M, F77L, M184V, L210W, T215Y	E138K	V35T, T39A, K43KE, E44ED, V60I, K82R, V118I, K122E, I135T, H208HY, A272P, K277R, T286A, E297A	B
Brindeiro (2002)	TVGG8	TVGG8	AY145786	AZT, DDI, 3TC, D4T	None	K65R, K70R, V75I, F77L, Y115F, F116Y, Q151M, K219E		K20R, S68G, I135T, R172K, D177E, T200A, R211K, V245M, A272P, Q278H, I293V, E297A	B
Clevenbergh (2002)	CP1902	CP1902	AF519424	D4T, 3TC	None	A62V, V75I, F77L, Y115F, F116Y, Q151M	Y181C	T69N, K122E, K173Q, Q174R, I202V, Q207E, R211K, V245T	B
Romano (2002)	MZ-pt38	pt38-t0	AF493373	AZT, DDI, D4T, 3TC, ABC	None	K65R, V75I, F77L, F116Y, Q151M		S68G, T69I, E79D, V118VI, D121Y, K122E, S162C, I178M, Q197E, T200A, E204D, R211T, F214L	B
		pt38-t1	AF493412	AZT, DDI, D4T, 3TC, ABC	None	K65R, V75I, F77L, F116Y, Q151M	Y181CF	V35I, S68G, E79D, R83K, V118I, D121Y, K122E, S162C, S163A, I178M, Q197E, T200A, R211AT, F214L	B
Venturi (2002)	GV-17	GV-17.1	AF517269	AZT, 3TC	None	M41ML, F77L, M184V, T215Y		E6ED, I142V, D177DE, I178IM, R211K	B
Gonzales (2003)	CA626	CA1193	AF513998	AZT, DDI, D4T, 3TC	None	D67G, K70G, F77L, F116Y, Q151M, M184V		S68N, Q207E, F214L, T286A	B
	CA1317	CA12527	AF514050	AZT, DDI, 3TC, D4T	None	V75I, F77L, Y115F, F116Y, Q151M, M184V		E40K, K46Q, K49R, I50V, T58N, S68G, K122E, Q174K, T200A, Q207E, R211K, K219T, V245T, E248D, D250E, S251D, A272P, K277R, T286A, A288S	B
	CA1524	CA13062	AF514093	AZT, DDI, 3TC, D4T	None	M41L, D67N, T69D, V75M, F77L, M184V, L210W, T215Y	E138K	V35T, T39A, E44ED, V60I, V118I, K122E, I135T, S162X, H208HY, R211RK, A272P, K277R, T286A	B
	CA4007	CA20207	AF514172	D4T, DDI, ABC, AZT, 3TC	None	K65R, K70R, V75I, F77L, Y115F, F116Y, Q151M, M184V		S68G, D121H, K122E, D177E, E203D, E248D, R284K, T286A, A288S, V292I, I293V	B
Gonzales (2003)	CA6434	CA15945	AY032387	AZT, 3TC, NRTI, D4T, DDI	None	A62V, V75I, F77L, F116Y, Q151M		K20R, K32E, V35I, K49R, I135V, S162CW, E169D, Q207E, R211K, A272P, I293V	B
	CA7052	CA17358	AF514250	AZT, D4T, DDI	None	A62V, K65KR, V75I, F77L, Q151M		A33V, V35T, S68G, K122E, D123N, I178L, T200A, H221HY, E248D, A272P, Q278QE, I293V, A299AG, A304G	B
Saah (2003)	AS-42	AS-42		AZT, D4T, DDI	None	F77L, F116Y, Q151M		V35T, V90I, D123E, I142V, D177E	B
Dumans (2004)	197	197	AY390154	AZT, DDI, D4T, 3TC	None	A62V, V75I, F77L, F116Y, Q151M, M184V, K219Q	E138K	K49R, I50V, S68G, K101Q, R172K, V179A, I202V, F214L	B
	208	208	AY390155	AZT, DDI, 3TC, D4T	None	K65R, K70R, V75I, F77L, Y115F, F116Y, Q151M, K219E		S68G, D177E	B
Kuritzkes (2004)	KDR_pat94	A0115	AY527932	D4T, 3TC	None	D67N, F77L, F116FY, Q151M, M184V		I135V, G196E, Q207K, R211A	B
Machado (2004)	cs160	cs160	AY313394	AZT, DDI, 3TC	None	M41L, D67E, V75M, F77L, M184V, L210W, T215Y		T39A, E44D, S68G, V118I, D123E, I135T, E138A, I142T, Q197L, R211K	B
	cs157	cs157	AY313424	AZT, DDI	None	A62V, V75I, F77L, F116Y, Q151M		K122E, I202V, F214L	B
Mo (2005)	9124	9124_d1		NRTI	None	M41L, D67N, T69DN, K70KR, V75I, F77L, F116Y, Q151M, M184V, T215FV, K219Q		K20R, S162D, K166R, G196E, I202V, Q207E, R211RK, A272P, K277KR, A288AS, E297EKQ	B
Non-B Workgroup (2005)	TH_146	TH_146	AY605559	AZT, DDI	None	V75I, F77L, Y115F, F116Y, Q151M, K219E	Y188YD	E28V, E29R, V35T, T39A, S68G, I135V, S162C, K173I, Q174K, V245R	B
Rhee (2005)	CA1317	CA7990	AY800863	AZT, DDI, 3TC, D4T	None	V75I, F77L, Y115F, F116Y, Q151M		K49R, I50V, S68G, K122E, T200A, E203EQ, Q207E, R211K, K219T, V245T, E248D, D250E, S251X, A272P, K277R	B
		CA9386	AY800864	AZT, DDI, 3TC, D4T	None	V75I, F77L, Y115F, F116Y, Q151M, M184V		E40EK, K46KQ, K49R, I50V, S68G, K122E, E169ED, T200A, Q207E, R211K, K219T, V245T, E248D, D250E	B
	CA1524	CA37776	AY801014	AZT, DDI, 3TC, D4T	None	M41L, D67N, T69D, V75M, F77L, M184V, L210W, T215Y	E138K	V35T, T39A, E44ED, V60I, K101KQ, V118VI, K122E, I135T, S162SDGN, H208HY, R211RK, K223KQ, V245VE, A272P, K277R, T286A, E297A	B
	CA8070	CA42626	AY801941	AZT, D4T, 3TC	None	M41L, V75M, F77L, M184V, T215FY		V21VI, E79ED, K102KE, K104R, I135V, S162DY, G196E, T200TIM, E203D, L283LF, R284K, T286A, I293V, E297K	B
	CA9831	CA24186	AY802137	AZT, 3TC	None	F77L, F116Y, Q151M, M184I		V35I, V90I, K122E, Q207E, R211K, A272P, K277R, V292I	B
	CA9933	CA24557	AY802197	D4T, DDI	None	V75I, F77L, F116Y, Q151M	V108VI	K20R, V35I, E79ED, R83K, V118I, E203D, F214L, T286A, A288T, E297K, K311KR, S322T, I329L, A376T, K390R, A400T, A437V, E449D, H483HN, K530R, A554S	B
	CA16095	CA38313	AY802425	AZT, 3TC, DDI	None	M41L, D67N, K70R, V75M, F77L, M184V, L210W, T215Y, K219Q		E44D, V60I, V118I, K122E, D123N, I135M, K166R, R211RK, D218E, L228H, K277R, T286A, E297K	B
Santos (2006)	FB109	FB109	DQ191035	AZT, DDI, 3TC, D4T	None	V75I, F77L, T215A		T58S, R83K, K122E, K173P, I178L, D192G, T200A, K201Q, Q207E, R211Q, E233A, V245Q	B
Villena (2007)	36708	36708-1	EF154391	D4T, 3TC, DDI	None	A62V, K70G, V75I, F77L, Y115F, F116Y, Q151M, M184V	Y181C	K20R, T39A, S68G, T69A, K101R, D123E, I135T, I167V, D177E, I202V, R211K, I293V, P294T, E297K, I375V, T386I, V435I, E449D, D460N, S468P, L491S, K512T, L517I, S519N	B
Rosen-Zvi (2008)	55	03p55-1		AZT, DDI, DDC	None	A62V, V75I, F77L, Q151M		K22N, I50S, V189I, R211K, F214L, T286A, I293V, E297A, E328D	B
Rhee (2009)	CA1524	CA63896	FJ983144	AZT, DDI, 3TC, D4T, TDF	None	M41L, D67N, T69D, V75M, F77L, M184V, L210W, T215Y	E138K	V35T, T39E, E44D, V60I, V118I, K122E, D123N, I135T, S162X, H208Y, R211K, V245VE, A272P, K277R, T286A, E297A	B
von Wyl (2010)	4814739	4814739	GQ848144	AZT, DDI	None	V75I, F77L, Y115F, F116Y, Q151M		V35I, S68SG, D123E, I135R, K173KQ, A272P, K281KR, T286P, E297K, K311KR, V317A, Q334R, M357T, T369A, I375V, A376T, T377L	B

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