<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype B
Gene RT
Mutation F77L
Rx >= 1 NRTI
(but no NNRTI)
IncludeMixtures No
References 34
Patients 48
Isolates 62
 
Show mutation frequency as:
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Shafer (1995)JIDP26JIDP26W88AF021308AZT, DDINoneA62V, V75I, F77L, F116Y, Q151M, K219E T39A, S68G, A98S, I135V, R172K, Q174H, R211G, F214L, V245MB
 JIDP25JIDP25W104AF021296AZT, DDINoneV75I, F77L, Y115F, F116Y, Q151M, K219E V35E, E36K, I37X, S48T, S68G, K122E, I142T, R211KB
 CA478CA899AF021299AZT, DDINoneF77L, F116Y, Q151M V35I, R83K, A158S, R211K, V245EB
Ruiz (1996)JCS-C13C13BZ99306AZT, DDINoneK65R, V75I, F77L, F116Y, Q151M V35M, T39K, K43E, S68G, T69I, K70X, K102Q, K122E, K166R, T200A, R211G, V245E, D250EB
  C13W24Z99307AZT, DDI, 3TCNoneK65R, V75I, F77L, F116Y, Q151M, M184V V35M, T39K, K43E, S68G, T69I, K70X, K102Q, K122E, K166R, T200A, R211G, V245E, D250EB
Cabana (1999)Cab-bB58AF102335DDC, AZT, 3TC, D4TNoneM41L, D67E, V75M, F77L, M184V, L210W, T215Y E40F, K43E, S68G, V118I, K122P, D123E, I135T, L149I, S162C, D177E, Q207E, R211KB
 Cab-lL0AF102366AZT, 3TC, DDINoneK65R, K70R, V75I, F77L, F116Y, Q151M T39K, K43E, S68G, T69I, K102Q, K122E, K166R, R211GB
  L39AF102367AZT, 3TC, DDI, D4TNoneK65R, K70R, V75I, F77L, Y115F, F116Y, Q151M, M184V T39K, K43E, S68G, T69I, K102Q, K122E, K166R, T200A, R211G, L228QB
  L47AF102368AZT, 3TC, DDI, D4TNoneK65R, K70R, V75I, F77L, Y115F, F116Y, Q151M, M184V, K219Q K43E, S68G, T69I, K102Q, K122E, K166R, T200A, R211G, L228KB
Pellegrin (1999)IP-36IP36-M12 D4T, DDINoneF77L, F116Y, Q151M S3ST, K20R, D123E, I142V, I178L, Q197L, Q207EB
Venturi (1999)GV-2Vent2W24AF169045AZT, DDINoneF77L V35I, R83K, D123E, Q207E, R211XB
Zolopa (1999)CA626CA3200AF088111AZT, DDI, D4T, 3TCNoneD67G, K70G, F77L, F116Y, Q151M, M184V I31X, S68N, Q207E, F214L, T286AB
Albrecht (2000)ACTG303_1212RT_bl AZT, DDINoneA62V, V75I, F77L, F116Y, Q151M V35VI, S68SG, T69A, R83K, K173R, Q174K, V245E, A272P, I293V, E297A, E302XB
  12RT_f1 AZT, DDI, 3TCNoneA62V, K65R, K70R, V75I, F77L, F116Y, Q151M, M184V T7P, V8G, V35VI, S68G, T69A, R83K, D123G, K173R, Q174K, V245E, A272P, I293V, L295T, E297AB
 ACTG303_13491349RT_bl AZT, DDINoneM41ML, V75I, F77L, Y115F, F116Y, Q151M, K219E K20KN, Y56YD, K66KN, S68G, T107P, D123E, S162T, K220KN, V245MB
  1349RT_f1 AZT, DDI, 3TCNoneA62V, V75I, F77L, Y115F, F116Y, Q151M, M184V, K219E V35I, S68G, D123E, S162T, V245M, K277R, Q278H, I293VB
 ACTG303_19341934RT_bl AZT, DDINoneV75I, F77L, Y115F, F116Y, Q151M K49R, I50V, S68SG, N81NI, K122E, E169D, T200A, Q207E, R211K, V245VM, E248DN, A272P, K277R, L279XB
  1934RT_f1 AZT, DDI, 3TCNoneV75I, F77L, Y115F, F116Y, Q151M, M184V K49R, I50V, S68G, V90I, K122E, E169D, T200A, Q207E, R211K, V245M, E248D, D250DE, A272P, K277R, T286A, A288S, V292I, E297KB
Balotta (2000)CB-216CB-216AF252070DDC, AZT, 3TC, DDINoneM41L, T69D, V75I, F77L M16V, V35E, E42K, K43N, E44D, T58SB
 CB-1CB-1AF186766DDC, AZT, 3TC, D4TNoneA62V, V75I, F77L, F116Y, Q151M, M184V, K219Q W24WG, E40K, K43N, I50IF, E53D, S68G, T107TP, V118I, D121H, K122E, I178L, T200A, I202V, R211T, F214LB
 CB-2CB-2AF186767AZT, DDI, 3TC, DDC, D4TNoneK65R, K70R, V75I, F77L, F116Y, Q151M V35I, S68G, R83K, D123E, K166R, D177E, G196E, R211KB
Baxter (2000)GART-G87GART-87 NRTI, AZT, 3TCNoneK65R, K70R, V75I, F77L, Y115F, F116Y, Q151M, M184V, K219E S68G, K122E, Q174K, D177E, T200A, Q207K, R211A, L234XB
Coakley (2000)EC34EC3480w D4T, DDINoneA62V, V75I, F77L, F116Y, Q151M K122E, I142D, R143W, A158S, I178M, R211G, A272P, T286A, I329VB
Miller (2000)MV-168MV-168wk48 ABC, AZT, 3TCNoneK65R, V75VIL, F77L, Y115F, Q151M, M184V V35I, S68G, K122E, I135T, G196E, E204DB
Shulman (2000)CA624CA9919AY802614DDI, D4T, 3TC, AZTNoneA62V, K70G, V75I, F77L, Y115F, F116Y, Q151M, M184V S68G, T69K, K122E, K166R, D177E, R211K, K277R, I293V, E297KB
Albrecht (2001)ACTG364_12081208 DDI, AZTNoneA62V, K70N, V75I, F77L, F116Y, Q151M E6D, T58N, S68G, D123E, I135T, S162C, D177E, I202V, Q207E, V245E, K277RB
Eshleman (2001)A021AF357625AF357625AZT, DDINoneV75I, F77L, F116Y, Q151M S68G, T69I, K122E, D123DN, G196E, F214FL, I257IL, V261I, T286A, E297KB
Gonzales (2001)CA624CA1189AY030418DDI, D4T, 3TC, AZTNoneA62V, K70G, V75I, F77L, Y115F, F116Y, Q151M, M184EV S68G, T69N, V148VE, K166KR, D177DE, I178M, Y183Y*B
 CA1166CA2649AY030474AZT, DDC, D4T, 3TCNoneK65R, K70R, V75I, F77L, Y115F, F116Y, Q151M, K219KE E6D, V35IM, S68G, K122E, I135T, T200I, I202V, T216TI, V245M, A272P, K275KR, E297DB
 CA1317CA3303AY030517AZT, DDI, 3TCNoneV75I, F77L, Y115F, F116Y, Q151M, M184V K46X, K49R, I50V, S68G, K122E, E169ED, T200A, Q207E, R211K, K219T, P243A, V245K, E248D, A272P, K277R, T286A, A288S, V292I, E297KB
 CA1524CA4366AY030643AZT, DDI, 3TC, D4TNoneM41L, D67N, T69D, V75M, F77L, M184V, L210W, T215YE138KV35T, T39A, K43KE, E44ED, V60I, K82R, V118I, K122E, I135T, H208HY, A272P, K277R, T286A, E297AB
Brindeiro (2002)TVGG8TVGG8AY145786AZT, DDI, 3TC, D4TNoneK65R, K70R, V75I, F77L, Y115F, F116Y, Q151M, K219E K20R, S68G, I135T, R172K, D177E, T200A, R211K, V245M, A272P, Q278H, I293V, E297AB
Clevenbergh (2002)CP1902CP1902AF519424D4T, 3TCNoneA62V, V75I, F77L, Y115F, F116Y, Q151MY181CT69N, K122E, K173Q, Q174R, I202V, Q207E, R211K, V245TB
Romano (2002)MZ-pt38pt38-t0AF493373AZT, DDI, D4T, 3TC, ABCNoneK65R, V75I, F77L, F116Y, Q151M S68G, T69I, E79D, V118VI, D121Y, K122E, S162C, I178M, Q197E, T200A, E204D, R211T, F214LB
Venturi (2002)GV-17GV-17.1AF517269AZT, 3TCNoneM41ML, F77L, M184V, T215Y E6ED, I142V, D177DE, I178IM, R211KB
Gonzales (2003)CA626CA1193AF513998AZT, DDI, D4T, 3TCNoneD67G, K70G, F77L, F116Y, Q151M, M184V S68N, Q207E, F214L, T286AB
 CA1317CA12527AF514050AZT, DDI, 3TC, D4TNoneV75I, F77L, Y115F, F116Y, Q151M, M184V E40K, K46Q, K49R, I50V, T58N, S68G, K122E, Q174K, T200A, Q207E, R211K, K219T, V245T, E248D, D250E, S251D, A272P, K277R, T286A, A288SB
 CA1524CA13062AF514093AZT, DDI, 3TC, D4TNoneM41L, D67N, T69D, V75M, F77L, M184V, L210W, T215YE138KV35T, T39A, E44ED, V60I, V118I, K122E, I135T, S162X, H208HY, R211RK, A272P, K277R, T286AB
 CA4007CA20207AF514172D4T, DDI, ABC, AZT, 3TCNoneK65R, K70R, V75I, F77L, Y115F, F116Y, Q151M, M184V S68G, D121H, K122E, D177E, E203D, E248D, R284K, T286A, A288S, V292I, I293VB
Gonzales (2003)CA6434CA15945AY032387AZT, 3TC, NRTI, D4T, DDINoneA62V, V75I, F77L, F116Y, Q151M K20R, K32E, V35I, K49R, I135V, S162CW, E169D, Q207E, R211K, A272P, I293VB
 CA7052CA17358AF514250AZT, D4T, DDINoneA62V, K65KR, V75I, F77L, Q151M A33V, V35T, S68G, K122E, D123N, I178L, T200A, H221HY, E248D, A272P, Q278QE, I293V, A299AG, A304GB
Saah (2003)AS-42AS-42 AZT, D4T, DDINoneF77L, F116Y, Q151M V35T, V90I, D123E, I142V, D177EB
Dumans (2004)197197AY390154AZT, DDI, D4T, 3TCNoneA62V, V75I, F77L, F116Y, Q151M, M184V, K219QE138KK49R, I50V, S68G, K101Q, R172K, V179A, I202V, F214LB
 208208AY390155AZT, DDI, 3TC, D4TNoneK65R, K70R, V75I, F77L, Y115F, F116Y, Q151M, K219E S68G, D177EB
Kuritzkes (2004)KDR_pat94A0115AY527932D4T, 3TCNoneD67N, F77L, F116FY, Q151M, M184V I135V, G196E, Q207K, R211AB
Machado (2004)cs160cs160AY313394AZT, DDI, 3TCNoneM41L, D67E, V75M, F77L, M184V, L210W, T215Y T39A, E44D, S68G, V118I, D123E, I135T, E138A, I142T, Q197L, R211KB
 cs157cs157AY313424AZT, DDINoneA62V, V75I, F77L, F116Y, Q151M K122E, I202V, F214LB
Mo (2005)91249124_d1 NRTINoneM41L, D67N, T69DN, K70KR, V75I, F77L, F116Y, Q151M, M184V, T215FV, K219Q K20R, S162D, K166R, G196E, I202V, Q207E, R211RK, A272P, K277KR, A288AS, E297EKQB
Non-B Workgroup (2005)TH_146TH_146AY605559AZT, DDINoneV75I, F77L, Y115F, F116Y, Q151M, K219EY188YDE28V, E29R, V35T, T39A, S68G, I135V, S162C, K173I, Q174K, V245RB
Rhee (2005)CA1317CA7990AY800863AZT, DDI, 3TC, D4TNoneV75I, F77L, Y115F, F116Y, Q151M K49R, I50V, S68G, K122E, T200A, E203EQ, Q207E, R211K, K219T, V245T, E248D, D250E, S251X, A272P, K277RB
  CA9386AY800864AZT, DDI, 3TC, D4TNoneV75I, F77L, Y115F, F116Y, Q151M, M184V E40EK, K46KQ, K49R, I50V, S68G, K122E, E169ED, T200A, Q207E, R211K, K219T, V245T, E248D, D250EB
 CA1524CA37776AY801014AZT, DDI, 3TC, D4TNoneM41L, D67N, T69D, V75M, F77L, M184V, L210W, T215YE138KV35T, T39A, E44ED, V60I, K101KQ, V118VI, K122E, I135T, S162SDGN, H208HY, R211RK, K223KQ, V245VE, A272P, K277R, T286A, E297A, M357K, I375V, A400T, V435E, D460N, R461K, T470A, L491S, Q524E, Q547R, A554TB
 CA8070CA42626AY801941AZT, D4T, 3TCNoneM41L, V75M, F77L, M184V, T215FY V21VI, E79ED, K102KE, K104R, I135V, S162DY, G196E, T200TIM, E203D, L283LF, R284K, T286A, I293V, E297KB
 CA9831CA24186AY802137AZT, 3TCNoneF77L, F116Y, Q151M, M184I V35I, V90I, K122E, Q207E, R211K, A272P, K277R, V292IB
 CA9933CA24557AY802197D4T, DDINoneV75I, F77L, F116Y, Q151MV108VIK20R, V35I, E79ED, R83K, V118I, E203D, F214L, T286A, A288T, E297K, K311KR, S322T, I329L, A376T, K390R, A400T, A437V, E449D, H483HN, K530R, A554SB
 CA16095CA38313AY802425AZT, 3TC, DDINoneM41L, D67N, K70R, V75M, F77L, M184V, L210W, T215Y, K219Q, N348I E44D, V60I, V118I, K122E, D123N, I135M, K166R, R211RK, D218E, L228H, K277R, V292I, I293V, E297A, A327T, I329M, Q330R, Q332L, Q334G, G335S, Q336QR, A360T, K366R, A371V, A376T, A400T, D460N, R461K, S468T, T470N, L491S, L517I, Q524E, A554S, K558RB
Santos (2006)FB109FB109DQ191035AZT, DDI, 3TC, D4TNoneV75I, F77L, T215A T58S, R83K, K122E, K173P, I178L, D192G, T200A, K201Q, Q207E, R211Q, E233A, V245QB
Villena (2007)3670836708-1EF154391D4T, 3TC, DDINoneA62V, K70G, V75I, F77L, Y115F, F116Y, Q151M, M184VY181CK20R, T39A, S68G, T69A, K101R, D123E, I135T, I167V, D177E, I202V, R211K, I293V, P294T, E297K, I375V, T386I, V435I, E449D, D460N, S468P, L491S, K512T, L517I, S519NB
Rosen-Zvi (2008)5503p55-1 AZT, DDI, DDCNoneA62V, V75I, F77L, Q151M K22N, I50S, V189I, R211K, F214L, T286A, I293V, E297A, E328DB
Rhee (2009)CA1524CA63896FJ983144AZT, DDI, 3TC, D4T, TDFNoneM41L, D67N, T69D, V75M, F77L, M184V, L210W, T215YE138KV35T, T39E, E44D, V60I, V118I, K122E, D123N, I135T, S162X, H208Y, R211K, V245VE, A272P, K277R, T286A, E297AB
von Wyl (2010)48147394814739GQ848144AZT, DDINoneV75I, F77L, Y115F, F116Y, Q151M V35I, S68SG, D123E, I135R, K173KQ, A272P, K281KR, T286P, E297K, K311KR, V317A, Q334R, M357T, T369A, I375V, A376T, T377LB
Grossman (2014)3333KF1350573TC, DDINoneM41L, D67N, T69D, K70KR, V75M, F77L, M184I, L210W, T215Y, K219R I37L, E44D, N57D, T58N, V60I, K65KE, K82KR, T84TA, D110DG, V118I, K122E, K126E, Q174K, N175Y, G196E, T200R, E203V, Q207E, R211A, D218E, Q242QLB