<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype B
Gene RT
Mutation V75M
Rx >= 1 NRTI
(but no NNRTI)
IncludeMixtures No
References 21
Patients 43
Isolates 57
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Ruiz (1996)JCS-C11C11BZ99304AZT, DDINoneM41L, D67N, K70R, V75M, L210W, T215Y, K219Q V60I, I135V, K173E, D177E, I178M, G196E, H208Y, R211K, D218E, L228HB
  C11W24Z99305AZT, DDI, 3TCNoneM41L, D67N, K70R, V75M, M184MV, L210W, T215Y, K219Q E44D, V60I, I135V, G196E, H208Y, R211K, D218E, L228HB
Hammer (1997)ACTG320_23332333 DDI, AZT, DDCNoneM41L, V75M, L210W, T215YK103KNE40F, K43E, V118I, K122E, I142T, S162C, I195L, G196E, R211K, K223Q, E224ED, L228R, A272P, I329L, M357T, S379G, V381I, A400T, A446S, L469IB
 ACTG320_617617 AZT, DDINoneM41L, D67G, T69D, K70R, V75M, L210W, T215Y, K219Q K20R, E44ED, V60I, R83K, S162Y, I178M, R211RK, D218DE, K277R, I293V, A360T, K390R, K395R, E399D, A400T, K451R, S468PB
Winters (1998)CA796CA4230AY802587AZT, DDI, D4T, 3TCNoneM41L, D67N, T69D, K70R, V75M, M184V, T215F, K219W V35T, V60I, K104KN, K122E, V179I, H208Y, D218E, L228H, E248QB
Cabana (1999)Cab-bB58AF102335DDC, AZT, 3TC, D4TNoneM41L, D67E, V75M, F77L, M184V, L210W, T215Y E40F, K43E, S68G, V118I, K122P, D123E, I135T, L149I, S162C, D177E, Q207E, R211KB
 Cab-II35AF102359AZT, DDI, 3TC, D4TNoneM41L, D67N, K70R, V75M, M184V, L210W, T215Y, K219Q E44D, V60I, K122E, D123N, Y127H, I135V, W153C, I178M, V179I, G196E, H208Y, R211K, D218E, L228HB
  I40AF102360AZT, DDI, 3TC, D4TNoneM41L, D67N, V75M, M184V, L210W, T215Y, K219Q E40F, K43E, V60I, K122E, D123N, I135V, I178M, V179I, G196E, H208Y, R211K, D218E, L228HB
Lawrence (1999)CA796CA10424AY802593AZT, DDI, D4T, 3TC, DDCNoneM41L, D67N, T69D, K70R, V75M, M184V, T215F, K219W V35T, V60I, K104KN, K122E, V179I, H208Y, D218E, L228H, E248QB
Albrecht (2000)ACTG303_10571057RT_f1 AZT, DDI, 3TCNoneM41L, D67N, V75M, M184V, L210W, T215Y K43E, E44A, V118I, K122E, A158S, S162D, E169D, Q207QE, R211K, L264F, N265DB
 ACTG303_35533553RT_f1 AZT, DDI, 3TCNoneM41L, D67N, K70R, V75M, M184V, T215F, K219WV108IK20R, V35M, T39A, V60I, T69TA, L109I, V118I, K122E, I135T, S162D, K166R, T200TI, I202V, D218E, V245Q, A272P, E291DB
Balotta (2000)CB-199CB-199AF252052AZT, D4T, 3TC, DDINoneV75M, M184V, T215Y K49R, R83K, K102Q, K122E, Q197K, R211KB
 CB-200CB-200AF252054DDC, AZT, D4T, 3TC, DDINoneM41L, D67N, V75M, M184V, L210W, T215YK101EE28D, E44D, V60I, R83K, V118I, D123E, I135R, G196E, Q207E, R211K, V245EB
 CB-218CB-218AF252072D4T, 3TC, DDC, AZT, DDINoneM41L, D67N, K70R, V75M, M184V, L210W, T215Y, K219E V35T, V60I, V118I, K122E, Y146X, N147X, D177E, G196E, I202V, E203K, Q207E, R211K, D218EB
 CB-224CB-224AF252079AZT, D4T, 3TC, DDINoneM41L, D67N, V75M, L210W, T215Y K20R, V35I, K43E, K73Q, V90I, V118VI, K122E, I135T, D177E, R211KB
Baxter (2000)GART-NG84GART-84 NRTI, AZT, 3TCNoneM41L, T69D, V75M, M184V, L210W, T215Y, K219R K43Q, E44D, A98S, V118I, K122E, I135L, G196E, E203EK, R211K, L228H, V245MB
Albrecht (2001)ACTG364_66086608 AZT, DDI, 3TCNoneM41L, D67N, V75M, M184MV, L210W, T215YA98AGV21I, V35L, T39A, E40F, K43E, V106VI, V118I, D121H, K122E, A158S, S162A, I178LM, E203D, H208Y, R211K, V245KR, A272PB
Gonzales (2001)CA631CA1203AY030419AZT, DDC, D4T, DDI, 3TCNoneM41L, D67N, V75M, M184V, L210W, T215Y, K219N E6D, V35X, T39A, E44D, V118I, K173T, E203K, Q207D, H208Y, R211KB
 CA1148CA2609AY030459AZT, DDI, 3TC, D4TNoneM41L, D67N, K70KR, V75M, M184MV, L210W, T215Y, K219N K20R, E44D, V60I, D123E, I142V, S162Y, G196E, Q197K, H208F, R211KB
 CA1524CA4366AY030643AZT, DDI, 3TC, D4TNoneM41L, D67N, T69D, V75M, F77L, M184V, L210W, T215YE138KV35T, T39A, K43KE, E44ED, V60I, K82R, V118I, K122E, I135T, H208HY, A272P, K277R, T286A, E297AB
 CA1595CA4544AY030693D4T, 3TCNoneM41L, D67N, T69D, V75M, M184V, L210W, T215YV108IV35VI, T39A, K43Q, E44D, T107A, L109V, V118I, K122E, D123E, S162C, I178L, V179I, V189I, G196E, H208Y, R211K, V245VE, A272P, E297QB
 CA3935CA9143AY030934D4T, 3TCNoneM41L, D67N, V75M, M184V, L210W, T215Y, K219Q K20R, V21VI, T39A, E44D, V60I, K103R, V118I, K122E, I132IV, I135T, K173R, Q174K, N175Y, G196E, H208Y, R211K, D218E, A272P, I293V, A304GB
 CA3983CA9232AY030982DDC, AZT, D4T, 3TCNoneM41L, D67N, K70R, V75M, M184V, T215Y, K219Q S3SC, V35L, T39A, V60I, K122E, I135T, I167IV, D177DN, I178M, G196E, E203K, Q207E, H208Y, W212LM, D218DE, K223E, L228H, L234LV, V245K, E248EVB
 CA4291CA10476AY031157DDC, AZT, 3TC, D4T, DDINoneM41L, D67N, K70R, V75M, T215F, K219Q K20R, Q23X, V60I, K103R, V118I, I135T, G196E, R211G, F214LB
 CA4333CA10525AY031197AZT, DDI, D4T, 3TCNoneM41L, D67N, V75M, M184V, L210W, T215Y K20R, V21I, T39K, K43E, E44D, V60I, K104N, V118I, K122E, I135V, I202V, R211KB
 CA4506CA10995AY031345NRTINoneM41L, D67N, K70R, V75M, L210LW, T215Y, K219Q K20R, A33AG, T39A, V60I, K104T, V118I, T139TI, Q207E, R211RK, D218DE, L228H, T296SB
 CA5508CA13656AY032035AZT, D4T, 3TC, DDI, DDC, ABCNoneM41L, V75M, M184V, L210W, T215Y K43E, K122E, I135V, K166R, E194EA, G196E, T200A, A272AS, T286A, E297KB
Servais (2001)JS18JS97439AJ401787AZT, 3TCNoneM41L, D67N, T69D, V75M, M184V, L210W, T215Y K43Q, E44D, V60I, K102R, V118I, K122E, I135M, E138A, I142V, T200A, R211K, F214WB
  JS98429AJ401827AZT, 3TCNoneM41L, D67N, T69D, V75M, L210W, T215YG190AE28G, K43Q, E44D, V60I, K102R, V118I, K122E, I135M, I142V, M184X, T200A, R211K, F214W, V245EB
 JS25JS98291AJ401815DDC, AZT, D4T, 3TCNoneM41L, V75M, M184V, L210W, T215Y D123E, D177E, I178V, V179I, T200I, L228R, V245K, W252GB
Tural (2002)880804880804 DDC, AZT, 3TC, D4TNoneM41L, D67N, V75M, M184V, L210W, T215YK101EK11R, K20R, K43E, V60I, A98S, I135V, T200AB
Gonzales (2003)CA1148CA10560AF514021AZT, DDI, 3TC, D4TNoneM41L, D67N, V75M, M184V, L210W, T215Y, K219N K20R, E44D, V60I, K122KE, D123E, I142V, S162Y, G196E, Q197K, E203D, H208F, R211K, S251I, A272P, I293VB
  CA35549AY802725AZT, DDI, 3TC, D4TNoneM41L, D67N, V75M, M184V, L210W, T215Y, K219N T7TP, K20R, E44D, V60I, D123E, I142V, S162Y, G196E, Q197K, E203D, H208F, R211K, S251I, A272P, I293VB
 CA1524CA13062AF514093AZT, DDI, 3TC, D4TNoneM41L, D67N, T69D, V75M, F77L, M184V, L210W, T215YE138KV35T, T39A, E44ED, V60I, V118I, K122E, I135T, S162X, H208HY, R211RK, A272P, K277R, T286AB
 CA3935CA12327AF514162D4T, 3TCNoneM41L, D67N, V75M, M184V, L210W, T215Y, K219Q K20R, V21I, T39A, E44D, V60I, K103R, V118I, K122E, I132IV, I135T, L149LP, K173R, Q174K, N175Y, G196E, H208Y, R211K, D218E, A272P, I293VB
Shafer (2003)A384_09010901bEF548333AZT, 3TCNoneM41L, D67N, V75M, M184MV, L210W, T215YG190SE6K, V35I, T39S, K43Q, E44D, R83K, K104N, K122E, V179I, Q197K, T200A, I202V, H208Y, R211K, H221Y, A288S, I293V, E297KB
Dumans (2004)237237AY390127AZT, DDI, 3TCNoneM41L, D67N, V75M, L210W, T215YA98GK43N, E44D, K82R, K122E, D123E, I167V, D177E, H208Y, R211K, D218EB
 238238AY390117AZT, DDI, 3TCNoneD67N, V75M, M184V, L210W, T215Y V60I, K122P, I135T, I142V, K166R, D177E, T200I, R211KB
 198198AY390118AZT, DDI, 3TC, D4TNoneM41L, V75M, M184V, L210W, T215Y K101Q, V118I, K122EB
Machado (2004)cs199cs199AY313399AZT, DDI, 3TC, D4TNoneM41L, D67N, T69D, V75M, M184V, L210W, T215YA98GK43Q, E44D, V118I, K122E, I135T, S162C, D177N, G196E, E203K, Q207E, H208Y, R211K, K223QB
 cs160cs160AY313394AZT, DDI, 3TCNoneM41L, D67E, V75M, F77L, M184V, L210W, T215Y T39A, E44D, S68G, V118I, D123E, I135T, E138A, I142T, Q197L, R211KB
 cs132cs132AY313379AZT, DDI, 3TCNoneM41L, D67N, V75M, M184V, L210W, T215Y K43N, E44D, I142V, F171Y, I178L, H208Y, R211KB
 cs146cs146AY313388AZT, DDI, 3TCNoneM41L, D67N, K70R, V75M, M184V, T215F V60I, V90I, I94L, I135T, S162YB
Mo (2005)89858985_d1 NRTINoneM41L, D67N, K70R, V75M, L210W, T215FY, K219HQK103N, V106A, F227LT39A, K43E, E44A, V60I, T69N, K102KR, V118I, K122E, I135V, I142V, D177N, I178M, G196E, E203EAKT, H208Y, D218E, V245KB
Rhee (2005)CA1148CA17417AY800771AZT, DDI, 3TC, D4T, ABC, NRTINoneM41L, D67N, K70KR, V75M, M184V, L210W, T215Y, K219N K20R, K43Q, E44D, V60I, K122E, D123X, I142V, S162Y, G196E, Q197K, E203D, H208F, R211K, S251I, A272P, K281KE, I293V, A299AGB
 CA1524CA37776AY801014AZT, DDI, 3TC, D4TNoneM41L, D67N, T69D, V75M, F77L, M184V, L210W, T215YE138KV35T, T39A, E44ED, V60I, K101KQ, V118VI, K122E, I135T, S162SDGN, H208HY, R211RK, K223KQ, V245VE, A272P, K277R, T286A, E297A, M357K, I375V, A400T, V435E, D460N, R461K, T470A, L491S, Q524E, Q547R, A554TB
 CA8070CA42626AY801941AZT, D4T, 3TCNoneM41L, V75M, F77L, M184V, T215FY V21VI, E79ED, K102KE, K104R, I135V, S162DY, G196E, T200TIM, E203D, L283LF, R284K, T286A, I293V, E297KB
 CA8380CA21109AY801983AZT, DDI, 3TCNoneM41L, D67N, V75M, M184V, L210W, T215Y K20R, K43Q, E44D, V118I, K122E, G196E, E203D, H208F, R211K, K238KR, Q278H, I293V, L303PB
 CA9694CA23726AY802064DDC, AZT, 3TC, D4TNoneM41L, T69S_SG, V75M, L210W, T215CY V35E, T39A, S68N, K122E, R211K, I293V, K331KN, Q334N, G335S, A360AT, K366R, T369V, A371V, I375V, A376T, T377L, A400T, E404D, V435A, K451R, D460N, R461K, V466A, S468P, Q480H, H483L, A554S, V559IB
 CA16095CA38313AY802425AZT, 3TC, DDINoneM41L, D67N, K70R, V75M, F77L, M184V, L210W, T215Y, K219Q, N348I E44D, V60I, V118I, K122E, D123N, I135M, K166R, R211RK, D218E, L228H, K277R, V292I, I293V, E297A, A327T, I329M, Q330R, Q332L, Q334G, G335S, Q336QR, A360T, K366R, A371V, A376T, A400T, D460N, R461K, S468T, T470N, L491S, L517I, Q524E, A554S, K558RB
Santos (2006)094094PR_RTAY275756D4T, 3TC, AZTNoneV75M, M184V D123E, S162C, K166R, R172KB
 098098PR_RTAY275758AZT, 3TCNoneM41L, D67N, K70R, V75M, L210W, T215Y, K219QG190ST39A, V60I, P97S, K122P, I135T, D177E, I178M, H198R, Q207H, R211KB
Rhee (2009)CA1524CA63896FJ983144AZT, DDI, 3TC, D4T, TDFNoneM41L, D67N, T69D, V75M, F77L, M184V, L210W, T215YE138KV35T, T39E, E44D, V60I, V118I, K122E, D123N, I135T, S162X, H208Y, R211K, V245VE, A272P, K277R, T286A, E297AB
Grossman (2014)3333KF1350563TC, DDINoneM41L, D67N, T69D, V75M, M184V, L210W, T215Y, K219R E44D, V60I, V118I, K122E, S134SG, Q174K, N175Y, G196E, T200R, Q207E, R211A, D218EB
  33KF1350573TC, DDINoneM41L, D67N, T69D, K70KR, V75M, F77L, M184I, L210W, T215Y, K219R I37L, E44D, N57D, T58N, V60I, K65KE, K82KR, T84TA, D110DG, V118I, K122E, K126E, Q174K, N175Y, G196E, T200R, E203V, Q207E, R211A, D218E, Q242QLB
  33KF1350583TC, DDI, D4TNoneM41L, D67N, T69D, V75M, M184I, L210W, T215Y, K219RK101KE, V108VI, Y181YC, G190GAI37L, E44D, V60I, V118I, K122E, K126KE, Q174K, N175Y, E194ED, G196E, T200R, E203V, Q207E, R211A, D218E, Q242LB
  33 3TC, DDI, D4TNoneM41L, D67N, T69D, V75M, M184I, L210W, T215Y, K219RV108II37L, E44D, V60I, V118I, K122E, Q174K, N175Y, V179VI, G196E, T200R, E203V, Q207E, R211A, D218E, L228V, Q242LB