Reverse Transcriptase Inhibitors

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Reverse Transcriptase Inhibitors

Subtype	B
Gene	RT
Mutation	V75M
Rx	>= 1 NRTI (but no NNRTI)
IncludeMixtures	No

References	20
Patients	42
Isolates	53

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	NRTIs	NNRTIs	NRTIDRMs	NNRTIDRMs	OtherMut	Subtype
Ruiz (1996)	JCS-C11	C11B	Z99304	AZT, DDI	None	M41L, D67N, K70R, V75M, L210W, T215Y, K219Q		V60I, I135V, K173E, D177E, I178M, G196E, H208Y, R211K, D218E, L228H	B
		C11W24	Z99305	AZT, DDI, 3TC	None	M41L, D67N, K70R, V75M, M184MV, L210W, T215Y, K219Q		E44D, V60I, I135V, G196E, H208Y, R211K, D218E, L228H	B
Hammer (1997)	ACTG320_2333	2333		DDI, AZT, DDC	None	M41L, V75M, L210W, T215Y	K103KN	E40F, K43E, V118I, K122E, I142T, S162C, I195L, G196E, R211K, K223Q, E224ED, L228R, A272P, I329L, M357T, S379G, V381I, A400T, A446S, L469I	B
	ACTG320_617	617		AZT, DDI	None	M41L, D67G, T69D, K70R, V75M, L210W, T215Y, K219Q		K20R, E44ED, V60I, R83K, S162Y, I178M, R211RK, D218DE, K277R, I293V, A360T, K390R, K395R, E399D, A400T, K451R, S468P	B
Winters (1998)	CA796	CA4230	AY802587	AZT, DDI, D4T, 3TC	None	M41L, D67N, T69D, K70R, V75M, M184V, T215F, K219W		V35T, V60I, K104KN, K122E, V179I, H208Y, D218E, L228H, E248Q	B
Cabana (1999)	Cab-b	B58	AF102335	DDC, AZT, 3TC, D4T	None	M41L, D67E, V75M, F77L, M184V, L210W, T215Y		E40F, K43E, S68G, V118I, K122P, D123E, I135T, L149I, S162C, D177E, Q207E, R211K	B
	Cab-I	I35	AF102359	AZT, DDI, 3TC, D4T	None	M41L, D67N, K70R, V75M, M184V, L210W, T215Y, K219Q		E44D, V60I, K122E, D123N, Y127H, I135V, W153C, I178M, V179I, G196E, H208Y, R211K, D218E, L228H	B
		I40	AF102360	AZT, DDI, 3TC, D4T	None	M41L, D67N, V75M, M184V, L210W, T215Y, K219Q		E40F, K43E, V60I, K122E, D123N, I135V, I178M, V179I, G196E, H208Y, R211K, D218E, L228H	B
Lawrence (1999)	CA796	CA10424	AY802593	AZT, DDI, D4T, 3TC, DDC	None	M41L, D67N, T69D, K70R, V75M, M184V, T215F, K219W		V35T, V60I, K104KN, K122E, V179I, H208Y, D218E, L228H, E248Q	B
Albrecht (2000)	ACTG303_1057	1057RT_f1		AZT, DDI, 3TC	None	M41L, D67N, V75M, M184V, L210W, T215Y		K43E, E44A, V118I, K122E, A158S, S162D, E169D, Q207QE, R211K, L264F, N265D	B
	ACTG303_3553	3553RT_f1		AZT, DDI, 3TC	None	M41L, D67N, K70R, V75M, M184V, T215F, K219W	V108I	K20R, V35M, T39A, V60I, T69TA, L109I, V118I, K122E, I135T, S162D, K166R, T200TI, I202V, D218E, V245Q, A272P, E291D	B
Balotta (2000)	CB-199	CB-199	AF252052	AZT, D4T, 3TC, DDI	None	V75M, M184V, T215Y		K49R, R83K, K102Q, K122E, Q197K, R211K	B
	CB-200	CB-200	AF252054	DDC, AZT, D4T, 3TC, DDI	None	M41L, D67N, V75M, M184V, L210W, T215Y	K101E	E28D, E44D, V60I, R83K, V118I, D123E, I135R, G196E, Q207E, R211K, V245E	B
	CB-218	CB-218	AF252072	D4T, 3TC, DDC, AZT, DDI	None	M41L, D67N, K70R, V75M, M184V, L210W, T215Y, K219E		V35T, V60I, V118I, K122E, Y146X, N147X, D177E, G196E, I202V, E203K, Q207E, R211K, D218E	B
	CB-224	CB-224	AF252079	AZT, D4T, 3TC, DDI	None	M41L, D67N, V75M, L210W, T215Y		K20R, V35I, K43E, K73Q, V90I, V118VI, K122E, I135T, D177E, R211K	B
Baxter (2000)	GART-NG84	GART-84		NRTI, AZT, 3TC	None	M41L, T69D, V75M, M184V, L210W, T215Y, K219R		K43Q, E44D, A98S, V118I, K122E, I135L, G196E, E203EK, R211K, L228H, V245M	B
Albrecht (2001)	ACTG364_6608	6608		AZT, DDI, 3TC	None	M41L, D67N, V75M, M184MV, L210W, T215Y	A98AG	V21I, V35L, T39A, E40F, K43E, V106VI, V118I, D121H, K122E, A158S, S162A, I178LM, E203D, H208Y, R211K, V245KR, A272P	B
Gonzales (2001)	CA631	CA1203	AY030419	AZT, DDC, D4T, DDI, 3TC	None	M41L, D67N, V75M, M184V, L210W, T215Y, K219N		E6D, V35X, T39A, E44D, V118I, K173T, E203K, Q207D, H208Y, R211K	B
	CA1148	CA2609	AY030459	AZT, DDI, 3TC, D4T	None	M41L, D67N, K70KR, V75M, M184MV, L210W, T215Y, K219N		K20R, E44D, V60I, D123E, I142V, S162Y, G196E, Q197K, H208F, R211K	B
	CA1524	CA4366	AY030643	AZT, DDI, 3TC, D4T	None	M41L, D67N, T69D, V75M, F77L, M184V, L210W, T215Y	E138K	V35T, T39A, K43KE, E44ED, V60I, K82R, V118I, K122E, I135T, H208HY, A272P, K277R, T286A, E297A	B
	CA1595	CA4544	AY030693	D4T, 3TC	None	M41L, D67N, T69D, V75M, M184V, L210W, T215Y	V108I	V35VI, T39A, K43Q, E44D, T107A, L109V, V118I, K122E, D123E, S162C, I178L, V179I, V189I, G196E, H208Y, R211K, V245VE, A272P, E297Q	B
	CA3935	CA9143	AY030934	D4T, 3TC	None	M41L, D67N, V75M, M184V, L210W, T215Y, K219Q		K20R, V21VI, T39A, E44D, V60I, K103R, V118I, K122E, I132IV, I135T, K173R, Q174K, N175Y, G196E, H208Y, R211K, D218E, A272P, I293V, A304G	B
	CA3983	CA9232	AY030982	DDC, AZT, D4T, 3TC	None	M41L, D67N, K70R, V75M, M184V, T215Y, K219Q		S3SC, V35L, T39A, V60I, K122E, I135T, I167IV, D177DN, I178M, G196E, E203K, Q207E, H208Y, W212LM, D218DE, K223E, L228H, L234LV, V245K, E248EV	B
	CA4291	CA10476	AY031157	DDC, AZT, 3TC, D4T, DDI	None	M41L, D67N, K70R, V75M, T215F, K219Q		K20R, Q23X, V60I, K103R, V118I, I135T, G196E, R211G, F214L	B
	CA4333	CA10525	AY031197	AZT, DDI, D4T, 3TC	None	M41L, D67N, V75M, M184V, L210W, T215Y		K20R, V21I, T39K, K43E, E44D, V60I, K104N, V118I, K122E, I135V, I202V, R211K	B
	CA4506	CA10995	AY031345	NRTI	None	M41L, D67N, K70R, V75M, L210LW, T215Y, K219Q		K20R, A33AG, T39A, V60I, K104T, V118I, T139TI, Q207E, R211RK, D218DE, L228H, T296S	B
	CA5508	CA13656	AY032035	AZT, D4T, 3TC, DDI, DDC, ABC	None	M41L, V75M, M184V, L210W, T215Y		K43E, K122E, I135V, K166R, E194EA, G196E, T200A, A272AS, T286A, E297K	B
Servais (2001)	JS18	JS97439	AJ401787	AZT, 3TC	None	M41L, D67N, T69D, V75M, M184V, L210W, T215Y		K43Q, E44D, V60I, K102R, V118I, K122E, I135M, E138A, I142V, T200A, R211K, F214W	B
		JS98429	AJ401827	AZT, 3TC	None	M41L, D67N, T69D, V75M, L210W, T215Y	G190A	E28G, K43Q, E44D, V60I, K102R, V118I, K122E, I135M, I142V, M184X, T200A, R211K, F214W, V245E	B
	JS25	JS98291	AJ401815	DDC, AZT, D4T, 3TC	None	M41L, V75M, M184V, L210W, T215Y		D123E, D177E, I178V, V179I, T200I, L228R, V245K, W252G	B
Tural (2002)	880804	880804		DDC, AZT, 3TC, D4T	None	M41L, D67N, V75M, M184V, L210W, T215Y	K101E	K11R, K20R, K43E, V60I, A98S, I135V, T200A	B
Gonzales (2003)	CA1148	CA10560	AF514021	AZT, DDI, 3TC, D4T	None	M41L, D67N, V75M, M184V, L210W, T215Y, K219N		K20R, E44D, V60I, K122KE, D123E, I142V, S162Y, G196E, Q197K, E203D, H208F, R211K, S251I, A272P, I293V	B
		CA35549	AY802725	AZT, DDI, 3TC, D4T	None	M41L, D67N, V75M, M184V, L210W, T215Y, K219N		T7TP, K20R, E44D, V60I, D123E, I142V, S162Y, G196E, Q197K, E203D, H208F, R211K, S251I, A272P, I293V	B
	CA1524	CA13062	AF514093	AZT, DDI, 3TC, D4T	None	M41L, D67N, T69D, V75M, F77L, M184V, L210W, T215Y	E138K	V35T, T39A, E44ED, V60I, V118I, K122E, I135T, S162X, H208HY, R211RK, A272P, K277R, T286A	B
	CA3935	CA12327	AF514162	D4T, 3TC	None	M41L, D67N, V75M, M184V, L210W, T215Y, K219Q		K20R, V21I, T39A, E44D, V60I, K103R, V118I, K122E, I132IV, I135T, L149LP, K173R, Q174K, N175Y, G196E, H208Y, R211K, D218E, A272P, I293V	B
Shafer (2003)	A384_0901	0901b	EF548333	AZT, 3TC	None	M41L, D67N, V75M, M184MV, L210W, T215Y	G190S	E6K, V35I, T39S, K43Q, E44D, R83K, K104N, K122E, V179I, Q197K, T200A, I202V, H208Y, R211K, H221Y, A288S, I293V, E297K	B
Dumans (2004)	237	237	AY390127	AZT, DDI, 3TC	None	M41L, D67N, V75M, L210W, T215Y	A98G	K43N, E44D, K82R, K122E, D123E, I167V, D177E, H208Y, R211K, D218E	B
	238	238	AY390117	AZT, DDI, 3TC	None	D67N, V75M, M184V, L210W, T215Y		V60I, K122P, I135T, I142V, K166R, D177E, T200I, R211K	B
	198	198	AY390118	AZT, DDI, 3TC, D4T	None	M41L, V75M, M184V, L210W, T215Y		K101Q, V118I, K122E	B
Machado (2004)	cs199	cs199	AY313399	AZT, DDI, 3TC, D4T	None	M41L, D67N, T69D, V75M, M184V, L210W, T215Y	A98G	K43Q, E44D, V118I, K122E, I135T, S162C, D177N, G196E, E203K, Q207E, H208Y, R211K, K223Q	B
	cs160	cs160	AY313394	AZT, DDI, 3TC	None	M41L, D67E, V75M, F77L, M184V, L210W, T215Y		T39A, E44D, S68G, V118I, D123E, I135T, E138A, I142T, Q197L, R211K	B
	cs132	cs132	AY313379	AZT, DDI, 3TC	None	M41L, D67N, V75M, M184V, L210W, T215Y		K43N, E44D, I142V, F171Y, I178L, H208Y, R211K	B
	cs146	cs146	AY313388	AZT, DDI, 3TC	None	M41L, D67N, K70R, V75M, M184V, T215F		V60I, V90I, I94L, I135T, S162Y	B
Mo (2005)	8985	8985_d1		NRTI	None	M41L, D67N, K70R, V75M, L210W, T215FY, K219HQ	K103N, V106A, F227L	T39A, K43E, E44A, V60I, T69N, K102KR, V118I, K122E, I135V, I142V, D177N, I178M, G196E, E203EAKT, H208Y, D218E, V245K	B
Rhee (2005)	CA1148	CA17417	AY800771	AZT, DDI, 3TC, D4T, ABC, NRTI	None	M41L, D67N, K70KR, V75M, M184V, L210W, T215Y, K219N		K20R, K43Q, E44D, V60I, K122E, D123X, I142V, S162Y, G196E, Q197K, E203D, H208F, R211K, S251I, A272P, K281KE, I293V, A299AG	B
	CA1524	CA37776	AY801014	AZT, DDI, 3TC, D4T	None	M41L, D67N, T69D, V75M, F77L, M184V, L210W, T215Y	E138K	V35T, T39A, E44ED, V60I, K101KQ, V118VI, K122E, I135T, S162SDGN, H208HY, R211RK, K223KQ, V245VE, A272P, K277R, T286A, E297A	B
	CA8070	CA42626	AY801941	AZT, D4T, 3TC	None	M41L, V75M, F77L, M184V, T215FY		V21VI, E79ED, K102KE, K104R, I135V, S162DY, G196E, T200TIM, E203D, L283LF, R284K, T286A, I293V, E297K	B
	CA8380	CA21109	AY801983	AZT, DDI, 3TC	None	M41L, D67N, V75M, M184V, L210W, T215Y		K20R, K43Q, E44D, V118I, K122E, G196E, E203D, H208F, R211K, K238KR, Q278H, I293V, L303P	B
	CA9694	CA23726	AY802064	DDC, AZT, 3TC, D4T	None	M41L, T69S_SG, V75M, L210W, T215CY		V35E, T39A, S68N, K122E, R211K, I293V, K331KN, Q334N, G335S, A360AT, K366R, T369V, A371V, I375V, A376T, T377L, A400T, E404D, V435A, K451R, D460N, R461K, V466A, S468P, Q480H, H483L, A554S, V559I	B
	CA16095	CA38313	AY802425	AZT, 3TC, DDI	None	M41L, D67N, K70R, V75M, F77L, M184V, L210W, T215Y, K219Q		E44D, V60I, V118I, K122E, D123N, I135M, K166R, R211RK, D218E, L228H, K277R, T286A, E297K	B
Santos (2006)	094	094PR_RT	AY275756	D4T, 3TC, AZT	None	V75M, M184V		D123E, S162C, K166R, R172K	B
	098	098PR_RT	AY275758	AZT, 3TC	None	M41L, D67N, K70R, V75M, L210W, T215Y, K219Q	G190S	T39A, V60I, P97S, K122P, I135T, D177E, I178M, H198R, Q207H, R211K	B
Rhee (2009)	CA1524	CA63896	FJ983144	AZT, DDI, 3TC, D4T, TDF	None	M41L, D67N, T69D, V75M, F77L, M184V, L210W, T215Y	E138K	V35T, T39E, E44D, V60I, V118I, K122E, D123N, I135T, S162X, H208Y, R211K, V245VE, A272P, K277R, T286A, E297A	B

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