Reverse Transcriptase Inhibitors

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Reverse Transcriptase Inhibitors

Subtype	B
Gene	RT
Mutation	V75I
Rx	>= 1 NRTI (but no NNRTI)
IncludeMixtures	No

References	35
Patients	50
Isolates	62

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	NRTIs	NNRTIs	NRTIDRMs	NNRTIDRMs	OtherMut	Subtype
Shafer (1995)	JIDP26	JIDP26W88	AF021308	AZT, DDI	None	A62V, V75I, F77L, F116Y, Q151M, K219E		T39A, S68G, A98S, I135V, R172K, Q174H, R211G, F214L, V245M	B
	JIDP25	JIDP25W104	AF021296	AZT, DDI	None	V75I, F77L, Y115F, F116Y, Q151M, K219E		V35E, E36K, I37X, S48T, S68G, K122E, I142T, R211K	B
Ruiz (1996)	JCS-C13	C13B	Z99306	AZT, DDI	None	K65R, V75I, F77L, F116Y, Q151M		V35M, T39K, K43E, S68G, T69I, K70X, K102Q, K122E, K166R, T200A, R211G, V245E, D250E	B
		C13W24	Z99307	AZT, DDI, 3TC	None	K65R, V75I, F77L, F116Y, Q151M, M184V		V35M, T39K, K43E, S68G, T69I, K70X, K102Q, K122E, K166R, T200A, R211G, V245E, D250E	B
Hammer (1997)	ACTG320_1118	1118		AZT, DDC	None	D67N, T69D, K70R, V75I, K219Q		V60I, K104N, I132V, T200AV, F214L, L228H, I293IV, K311R, R358RK, K366KR, A371AV, A376T, E399D, A400L, R461K, H483HY, D488X	B
	ACTG320_846	846		AZT, DDI, DDC	None	V75I, K219Q		S48T, V60I, D121H, K122E, I142V, I178L, A272P, K277R, T286TA, I293IV, A400S, E404D, W406WG, V435IM	B
Cabana (1999)	Cab-l	L0	AF102366	AZT, 3TC, DDI	None	K65R, K70R, V75I, F77L, F116Y, Q151M		T39K, K43E, S68G, T69I, K102Q, K122E, K166R, R211G	B
		L39	AF102367	AZT, 3TC, DDI, D4T	None	K65R, K70R, V75I, F77L, Y115F, F116Y, Q151M, M184V		T39K, K43E, S68G, T69I, K102Q, K122E, K166R, T200A, R211G, L228Q	B
		L47	AF102368	AZT, 3TC, DDI, D4T	None	K65R, K70R, V75I, F77L, Y115F, F116Y, Q151M, M184V, K219Q		K43E, S68G, T69I, K102Q, K122E, K166R, T200A, R211G, L228K	B
Lawrence (1999)	JL-Pt11	JL-11-post		AZT, DDC, D4T, 3TC, DDI	None	D67N, K70S, V75I, F116Y, Q151M, T215Y		T58S, F77V, D121H, K122E, I135V, D177E, Q242X	B
Albrecht (2000)	ACTG303_12	12RT_bl		AZT, DDI	None	A62V, V75I, F77L, F116Y, Q151M		V35VI, S68SG, T69A, R83K, K173R, Q174K, V245E, A272P, I293V, E297A, E302X	B
		12RT_f1		AZT, DDI, 3TC	None	A62V, K65R, K70R, V75I, F77L, F116Y, Q151M, M184V		T7P, V8G, V35VI, S68G, T69A, R83K, D123G, K173R, Q174K, V245E, A272P, I293V, L295T, E297A	B
	ACTG303_1349	1349RT_bl		AZT, DDI	None	M41ML, V75I, F77L, Y115F, F116Y, Q151M, K219E		K20KN, Y56YD, K66KN, S68G, T107P, D123E, S162T, K220KN, V245M	B
		1349RT_f1		AZT, DDI, 3TC	None	A62V, V75I, F77L, Y115F, F116Y, Q151M, M184V, K219E		V35I, S68G, D123E, S162T, V245M, K277R, Q278H, I293V	B
	ACTG303_1934	1934RT_bl		AZT, DDI	None	V75I, F77L, Y115F, F116Y, Q151M		K49R, I50V, S68SG, N81NI, K122E, E169D, T200A, Q207E, R211K, V245VM, E248DN, A272P, K277R, L279X	B
		1934RT_f1		AZT, DDI, 3TC	None	V75I, F77L, Y115F, F116Y, Q151M, M184V		K49R, I50V, S68G, V90I, K122E, E169D, T200A, Q207E, R211K, V245M, E248D, D250DE, A272P, K277R, T286A, A288S, V292I, E297K	B
Bacheler (2000)	LB3-P25	P25-0		NRTI	None	A62V, V75I		K20R, R83K, K103R, G196E, T200A, R211K	B
Balotta (2000)	CB-216	CB-216	AF252070	DDC, AZT, 3TC, DDI	None	M41L, T69D, V75I, F77L		M16V, V35E, E42K, K43N, E44D, T58S	B
	CB-1	CB-1	AF186766	DDC, AZT, 3TC, D4T	None	A62V, V75I, F77L, F116Y, Q151M, M184V, K219Q		W24WG, E40K, K43N, I50IF, E53D, S68G, T107TP, V118I, D121H, K122E, I178L, T200A, I202V, R211T, F214L	B
	CB-2	CB-2	AF186767	AZT, DDI, 3TC, DDC, D4T	None	K65R, K70R, V75I, F77L, F116Y, Q151M		V35I, S68G, R83K, D123E, K166R, D177E, G196E, R211K	B
Baxter (2000)	GART-G87	GART-87		NRTI, AZT, 3TC	None	K65R, K70R, V75I, F77L, Y115F, F116Y, Q151M, M184V, K219E		S68G, K122E, Q174K, D177E, T200A, Q207K, R211A, L234X	B
Coakley (2000)	EC34	EC3480w		D4T, DDI	None	A62V, V75I, F77L, F116Y, Q151M		K122E, I142D, R143W, A158S, I178M, R211G, A272P, T286A, I329V	B
Miller (2000)	MV-199	MV-199wk16		ABC	None	V75I, Y115F, L210LW		S162C, T200X, E204D	B
Shulman (2000)	CA624	CA9919	AY802614	DDI, D4T, 3TC, AZT	None	A62V, K70G, V75I, F77L, Y115F, F116Y, Q151M, M184V		S68G, T69K, K122E, K166R, D177E, R211K, K277R, I293V, E297K	B
Albrecht (2001)	ACTG364_1208	1208		DDI, AZT	None	A62V, K70N, V75I, F77L, F116Y, Q151M		E6D, T58N, S68G, D123E, I135T, S162C, D177E, I202V, Q207E, V245E, K277R	B
	ACTG364_4362	4362		AZT, DDI	None	M41L, A62AV, V75I		K104R, I142V, K166R, Q207QHKN, R211KQ	B
Cinque (2001)	Pat6	6pla_BL	AF259921	AZT, D4T, 3TC	None	V75I		V35M, R83K, V90I, K122E, V179VA, V189VI, R211K	B
Delgado (2001)	ED_V24	ED_V24	AY016934	AZT, 3TC	None	M41L, A62AV, K65R, V75I, F116Y		V60I, S68R, D123E, I132IV, Q151X, S162CY, E169D, I178L, Q207E	B
Eshleman (2001)	A021	AF357625	AF357625	AZT, DDI	None	V75I, F77L, F116Y, Q151M		S68G, T69I, K122E, D123DN, G196E, F214FL, I257IL, V261I, T286A, E297K	B
Gonzales (2001)	CA624	CA1189	AY030418	DDI, D4T, 3TC, AZT	None	A62V, K70G, V75I, F77L, Y115F, F116Y, Q151M, M184EV		S68G, T69N, V148VE, K166KR, D177DE, I178M, Y183Y*	B
	CA1166	CA2649	AY030474	AZT, DDC, D4T, 3TC	None	K65R, K70R, V75I, F77L, Y115F, F116Y, Q151M, K219KE		E6D, V35IM, S68G, K122E, I135T, T200I, I202V, T216TI, V245M, A272P, K275KR, E297D	B
	CA1317	CA3303	AY030517	AZT, DDI, 3TC	None	V75I, F77L, Y115F, F116Y, Q151M, M184V		K46X, K49R, I50V, S68G, K122E, E169ED, T200A, Q207E, R211K, K219T, P243A, V245K, E248D, A272P, K277R, T286A, A288S, V292I, E297K	B
	CA1467	CA3912	AY030602	AZT, 3TC, DDC, D4T	None	M41L, D67N, T69D, V75I, F116Y, Q151M, L210W, T215Y	V108I	R83K, D123E, K166R, D177E, I202V, A272P, I293V	B
Brindeiro (2002)	TVGG8	TVGG8	AY145786	AZT, DDI, 3TC, D4T	None	K65R, K70R, V75I, F77L, Y115F, F116Y, Q151M, K219E		K20R, S68G, I135T, R172K, D177E, T200A, R211K, V245M, A272P, Q278H, I293V, E297A	B
Clevenbergh (2002)	CP1902	CP1902	AF519424	D4T, 3TC	None	A62V, V75I, F77L, Y115F, F116Y, Q151M	Y181C	T69N, K122E, K173Q, Q174R, I202V, Q207E, R211K, V245T	B
Naugler (2002)	WES-10	HIV10BL	AF422707	AZT	None	K70R, V75I, T215S, K219Q		K64R, D123E, I142T, D177E, I178M, R211K, F214L	B
		HIV10ES	AF422732	AZT, DDI	None	K70R, V75I, T215S, K219Q		K64R, D123E, I142T, D177E, I178M, Q207P, R211K, F214L	B
	WES-15	HIV15BL	AF422712	AZT	None	M41L, D67N, K70R, V75I, L210W, T215Y		V35L, T39E, V60I, S162A, E169D, G196E, R211K, D218E, K219T	B
	WES-20	HIV20BL	AF422717	AZT	None	M41L, D67N, V75I, T215Y		V35I, K166R, T200A, R211K	B
Romano (2002)	MZ-pt38	pt38-t0	AF493373	AZT, DDI, D4T, 3TC, ABC	None	K65R, V75I, F77L, F116Y, Q151M		S68G, T69I, E79D, V118VI, D121Y, K122E, S162C, I178M, Q197E, T200A, E204D, R211T, F214L	B
		pt38-t1	AF493412	AZT, DDI, D4T, 3TC, ABC	None	K65R, V75I, F77L, F116Y, Q151M	Y181CF	V35I, S68G, E79D, R83K, V118I, D121Y, K122E, S162C, S163A, I178M, Q197E, T200A, R211AT, F214L	B
Tural (2002)	880814	880814		AZT, D4T, DDI, 3TC	None	M41L, K65R, V75I, F116Y, Q151M		K49R, I50V, V60I, S68G, T69I, K122E, I135T, I142M, T165I, D177E, F214L, V245M	B
Gonzales (2003)	CA1317	CA12527	AF514050	AZT, DDI, 3TC, D4T	None	V75I, F77L, Y115F, F116Y, Q151M, M184V		E40K, K46Q, K49R, I50V, T58N, S68G, K122E, Q174K, T200A, Q207E, R211K, K219T, V245T, E248D, D250E, S251D, A272P, K277R, T286A, A288S	B
	CA4007	CA20207	AF514172	D4T, DDI, ABC, AZT, 3TC	None	K65R, K70R, V75I, F77L, Y115F, F116Y, Q151M, M184V		S68G, D121H, K122E, D177E, E203D, E248D, R284K, T286A, A288S, V292I, I293V	B
Gonzales (2003)	CA6434	CA15945	AY032387	AZT, 3TC, NRTI, D4T, DDI	None	A62V, V75I, F77L, F116Y, Q151M		K20R, K32E, V35I, K49R, I135V, S162CW, E169D, Q207E, R211K, A272P, I293V	B
	CA7052	CA17358	AF514250	AZT, D4T, DDI	None	A62V, K65KR, V75I, F77L, Q151M		A33V, V35T, S68G, K122E, D123N, I178L, T200A, H221HY, E248D, A272P, Q278QE, I293V, A299AG, A304G	B
Dumans (2004)	180	180	AY390156	AZT, DDI	None	V75I, Y115F, F116Y, Q151M, K219Q		S68G, D177E, R211K	B
	197	197	AY390154	AZT, DDI, D4T, 3TC	None	A62V, V75I, F77L, F116Y, Q151M, M184V, K219Q	E138K	K49R, I50V, S68G, K101Q, R172K, V179A, I202V, F214L	B
	208	208	AY390155	AZT, DDI, 3TC, D4T	None	K65R, K70R, V75I, F77L, Y115F, F116Y, Q151M, K219E		S68G, D177E	B
Machado (2004)	cs157	cs157	AY313424	AZT, DDI	None	A62V, V75I, F77L, F116Y, Q151M		K122E, I202V, F214L	B
Garcia-Bujalance (2005)	GBS_31	GBS_31	AY872366	DDC, AZT, 3TC	None	A62V, V75I, M184V		E40ED, K43N, A98S, G196E, R211K, V245E	B
Mo (2005)	9124	9124_d1		NRTI	None	M41L, D67N, T69DN, K70KR, V75I, F77L, F116Y, Q151M, M184V, T215FV, K219Q		K20R, S162D, K166R, G196E, I202V, Q207E, R211RK, A272P, K277KR, A288AS, E297EKQ	B
Non-B Workgroup (2005)	TH_146	TH_146	AY605559	AZT, DDI	None	V75I, F77L, Y115F, F116Y, Q151M, K219E	Y188YD	E28V, E29R, V35T, T39A, S68G, I135V, S162C, K173I, Q174K, V245R	B
Rhee (2005)	CA1317	CA7990	AY800863	AZT, DDI, 3TC, D4T	None	V75I, F77L, Y115F, F116Y, Q151M		K49R, I50V, S68G, K122E, T200A, E203EQ, Q207E, R211K, K219T, V245T, E248D, D250E, S251X, A272P, K277R	B
		CA9386	AY800864	AZT, DDI, 3TC, D4T	None	V75I, F77L, Y115F, F116Y, Q151M, M184V		E40EK, K46KQ, K49R, I50V, S68G, K122E, E169ED, T200A, Q207E, R211K, K219T, V245T, E248D, D250E	B
	CA9798	CA24062	AY802119	D4T, 3TC	None	M41ML, K70S, V75I, M184V		K20R, S68G, R83K, V90I, I135T, S162C, I178M, G196GE, Q197QE, S251C, K277R, T286A, I293V	B
	CA9933	CA24557	AY802197	D4T, DDI	None	V75I, F77L, F116Y, Q151M	V108VI	K20R, V35I, E79ED, R83K, V118I, E203D, F214L, T286A, A288T, E297K, K311KR, S322T, I329L, A376T, K390R, A400T, A437V, E449D, H483HN, K530R, A554S	B
Santos (2006)	FB109	FB109	DQ191035	AZT, DDI, 3TC, D4T	None	V75I, F77L, T215A		T58S, R83K, K122E, K173P, I178L, D192G, T200A, K201Q, Q207E, R211Q, E233A, V245Q	B
Villena (2007)	36708	36708-1	EF154391	D4T, 3TC, DDI	None	A62V, K70G, V75I, F77L, Y115F, F116Y, Q151M, M184V	Y181C	K20R, T39A, S68G, T69A, K101R, D123E, I135T, I167V, D177E, I202V, R211K, I293V, P294T, E297K, I375V, T386I, V435I, E449D, D460N, S468P, L491S, K512T, L517I, S519N	B
Riddler (2008)	RG10828	RG10828w66		TDF, 3TC	None	V75I		Q197E, R211K, V245M, K281R, I293V, S322T, M357I, A376T	B
Rosen-Zvi (2008)	55	03p55-1		AZT, DDI, DDC	None	A62V, V75I, F77L, Q151M		K22N, I50S, V189I, R211K, F214L, T286A, I293V, E297A, E328D	B
von Wyl (2010)	4814739	4814739	GQ848144	AZT, DDI	None	V75I, F77L, Y115F, F116Y, Q151M		V35I, S68SG, D123E, I135R, K173KQ, A272P, K281KR, T286P, E297K, K311KR, V317A, Q334R, M357T, T369A, I375V, A376T, T377L	B

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