<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype B
Gene RT
Mutation V75I
Rx >= 1 NRTI
(but no NNRTI)
IncludeMixtures No
References 35
Patients 50
Isolates 61
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Shafer (1995)JIDP26JIDP26W88AF021308AZT, DDINoneA62V, V75I, F77L, F116Y, Q151M, K219E T39A, S68G, A98S, I135V, R172K, Q174H, R211G, F214L, V245MB
 JIDP25JIDP25W104AF021296AZT, DDINoneV75I, F77L, Y115F, F116Y, Q151M, K219E V35E, E36K, I37X, S48T, S68G, K122E, I142T, R211KB
Ruiz (1996)JCS-C13C13BZ99306AZT, DDINoneK65R, V75I, F77L, F116Y, Q151M V35M, T39K, K43E, S68G, T69I, K70X, K102Q, K122E, K166R, T200A, R211G, V245E, D250EB
  C13W24Z99307AZT, DDI, 3TCNoneK65R, V75I, F77L, F116Y, Q151M, M184V V35M, T39K, K43E, S68G, T69I, K70X, K102Q, K122E, K166R, T200A, R211G, V245E, D250EB
Hammer (1997)ACTG320_11181118 AZT, DDCNoneD67N, T69D, K70R, V75I, K219Q V60I, K104N, I132V, T200AV, F214L, L228H, I293IV, K311R, R358RK, K366KR, A371AV, A376T, E399D, A400L, R461K, H483HY, D488XB
 ACTG320_846846 AZT, DDI, DDCNoneV75I, K219Q S48T, V60I, D121H, K122E, I142V, I178L, A272P, K277R, T286TA, I293IV, A400S, E404D, W406WG, V435IMB
Cabana (1999)Cab-lL0AF102366AZT, 3TC, DDINoneK65R, K70R, V75I, F77L, F116Y, Q151M T39K, K43E, S68G, T69I, K102Q, K122E, K166R, R211GB
  L39AF102367AZT, 3TC, DDI, D4TNoneK65R, K70R, V75I, F77L, Y115F, F116Y, Q151M, M184V T39K, K43E, S68G, T69I, K102Q, K122E, K166R, T200A, R211G, L228QB
  L47AF102368AZT, 3TC, DDI, D4TNoneK65R, K70R, V75I, F77L, Y115F, F116Y, Q151M, M184V, K219Q K43E, S68G, T69I, K102Q, K122E, K166R, T200A, R211G, L228KB
Lawrence (1999)JL-Pt11JL-11-post AZT, DDC, D4T, 3TC, DDINoneD67N, K70S, V75I, F116Y, Q151M, T215Y T58S, F77V, D121H, K122E, I135V, D177E, Q242XB
Albrecht (2000)ACTG303_1212RT_bl AZT, DDINoneA62V, V75I, F77L, F116Y, Q151M V35VI, S68SG, T69A, R83K, K173R, Q174K, V245E, A272P, I293V, E297A, E302XB
  12RT_f1 AZT, DDI, 3TCNoneA62V, K65R, K70R, V75I, F77L, F116Y, Q151M, M184V T7P, V8G, V35VI, S68G, T69A, R83K, D123G, K173R, Q174K, V245E, A272P, I293V, L295T, E297AB
 ACTG303_13491349RT_bl AZT, DDINoneM41ML, V75I, F77L, Y115F, F116Y, Q151M, K219E K20KN, Y56YD, K66KN, S68G, T107P, D123E, S162T, K220KN, V245MB
  1349RT_f1 AZT, DDI, 3TCNoneA62V, V75I, F77L, Y115F, F116Y, Q151M, M184V, K219E V35I, S68G, D123E, S162T, V245M, K277R, Q278H, I293VB
 ACTG303_19341934RT_bl AZT, DDINoneV75I, F77L, Y115F, F116Y, Q151M K49R, I50V, S68SG, N81NI, K122E, E169D, T200A, Q207E, R211K, V245VM, E248DN, A272P, K277R, L279XB
  1934RT_f1 AZT, DDI, 3TCNoneV75I, F77L, Y115F, F116Y, Q151M, M184V K49R, I50V, S68G, V90I, K122E, E169D, T200A, Q207E, R211K, V245M, E248D, D250DE, A272P, K277R, T286A, A288S, V292I, E297KB
Bacheler (2000)LB3-P25P25-0 NRTINoneA62V, V75I K20R, R83K, K103R, G196E, T200A, R211KB
Balotta (2000)CB-216CB-216AF252070DDC, AZT, 3TC, DDINoneM41L, T69D, V75I, F77L M16V, V35E, E42K, K43N, E44D, T58SB
 CB-1CB-1AF186766DDC, AZT, 3TC, D4TNoneA62V, V75I, F77L, F116Y, Q151M, M184V, K219Q W24WG, E40K, K43N, I50IF, E53D, S68G, T107TP, V118I, D121H, K122E, I178L, T200A, I202V, R211T, F214LB
 CB-2CB-2AF186767AZT, DDI, 3TC, DDC, D4TNoneK65R, K70R, V75I, F77L, F116Y, Q151M V35I, S68G, R83K, D123E, K166R, D177E, G196E, R211KB
Baxter (2000)GART-G87GART-87 NRTI, AZT, 3TCNoneK65R, K70R, V75I, F77L, Y115F, F116Y, Q151M, M184V, K219E S68G, K122E, Q174K, D177E, T200A, Q207K, R211A, L234XB
Coakley (2000)EC34EC3480w D4T, DDINoneA62V, V75I, F77L, F116Y, Q151M K122E, I142D, R143W, A158S, I178M, R211G, A272P, T286A, I329VB
Miller (2000)MV-199MV-199wk16 ABCNoneV75I, Y115F, L210LW S162C, T200X, E204DB
Shulman (2000)CA624CA9919AY802614DDI, D4T, 3TC, AZTNoneA62V, K70G, V75I, F77L, Y115F, F116Y, Q151M, M184V S68G, T69K, K122E, K166R, D177E, R211K, K277R, I293V, E297KB
Albrecht (2001)ACTG364_12081208 DDI, AZTNoneA62V, K70N, V75I, F77L, F116Y, Q151M E6D, T58N, S68G, D123E, I135T, S162C, D177E, I202V, Q207E, V245E, K277RB
 ACTG364_43624362 AZT, DDINoneM41L, A62AV, V75I K104R, I142V, K166R, Q207QHKN, R211KQB
Cinque (2001)Pat66pla_BLAF259921AZT, D4T, 3TCNoneV75I V35M, R83K, V90I, K122E, V179VA, V189VI, R211KB
Delgado (2001)ED_V24ED_V24AY016934AZT, 3TCNoneM41L, A62AV, K65R, V75I, F116Y V60I, S68R, D123E, I132IV, Q151X, S162CY, E169D, I178L, Q207EB
Eshleman (2001)A021AF357625AF357625AZT, DDINoneV75I, F77L, F116Y, Q151M S68G, T69I, K122E, D123DN, G196E, F214FL, I257IL, V261I, T286A, E297KB
Gonzales (2001)CA624CA1189AY030418DDI, D4T, 3TC, AZTNoneA62V, K70G, V75I, F77L, Y115F, F116Y, Q151M, M184EV S68G, T69N, V148VE, K166KR, D177DE, I178M, Y183Y*B
 CA1166CA2649AY030474AZT, DDC, D4T, 3TCNoneK65R, K70R, V75I, F77L, Y115F, F116Y, Q151M, K219KE E6D, V35IM, S68G, K122E, I135T, T200I, I202V, T216TI, V245M, A272P, K275KR, E297DB
 CA1317CA3303AY030517AZT, DDI, 3TCNoneV75I, F77L, Y115F, F116Y, Q151M, M184V K46X, K49R, I50V, S68G, K122E, E169ED, T200A, Q207E, R211K, K219T, P243A, V245K, E248D, A272P, K277R, T286A, A288S, V292I, E297KB
 CA1467CA3912AY030602AZT, 3TC, DDC, D4TNoneM41L, D67N, T69D, V75I, F116Y, Q151M, L210W, T215YV108IR83K, D123E, K166R, D177E, I202V, A272P, I293VB
Brindeiro (2002)TVGG8TVGG8AY145786AZT, DDI, 3TC, D4TNoneK65R, K70R, V75I, F77L, Y115F, F116Y, Q151M, K219E K20R, S68G, I135T, R172K, D177E, T200A, R211K, V245M, A272P, Q278H, I293V, E297AB
Clevenbergh (2002)CP1902CP1902AF519424NRTI, D4T, 3TCNoneA62V, V75I, F77L, Y115F, F116Y, Q151MY181CT69N, K122E, K173Q, Q174R, I202V, Q207E, R211K, V245TB
Naugler (2002)WES-10HIV10BLAF422707AZTNoneK70R, V75I, T215S, K219Q K64R, D123E, I142T, D177E, I178M, R211K, F214LB
  HIV10ESAF422732AZT, DDINoneK70R, V75I, T215S, K219Q K64R, D123E, I142T, D177E, I178M, Q207P, R211K, F214LB
 WES-15HIV15BLAF422712AZTNoneM41L, D67N, K70R, V75I, L210W, T215Y V35L, T39E, V60I, S162A, E169D, G196E, R211K, D218E, K219TB
 WES-20HIV20BLAF422717AZTNoneM41L, D67N, V75I, T215Y V35I, K166R, T200A, R211KB
Romano (2002)MZ-pt38pt38-t0AF493373AZT, DDI, D4T, 3TC, ABCNoneK65R, V75I, F77L, F116Y, Q151M S68G, T69I, E79D, V118VI, D121Y, K122E, S162C, I178M, Q197E, T200A, E204D, R211T, F214LB
Tural (2002)880814880814 AZT, D4T, DDI, 3TCNoneM41L, K65R, V75I, F116Y, Q151M K49R, I50V, V60I, S68G, T69I, K122E, I135T, I142M, T165I, D177E, F214L, V245MB
Gonzales (2003)CA1317CA12527AF514050AZT, DDI, 3TC, D4TNoneV75I, F77L, Y115F, F116Y, Q151M, M184V E40K, K46Q, K49R, I50V, T58N, S68G, K122E, Q174K, T200A, Q207E, R211K, K219T, V245T, E248D, D250E, S251D, A272P, K277R, T286A, A288SB
 CA4007CA20207AF514172D4T, DDI, ABC, AZT, 3TCNoneK65R, K70R, V75I, F77L, Y115F, F116Y, Q151M, M184V S68G, D121H, K122E, D177E, E203D, E248D, R284K, T286A, A288S, V292I, I293VB
Gonzales (2003)CA6434CA15945AY032387AZT, 3TC, NRTI, D4T, DDINoneA62V, V75I, F77L, F116Y, Q151M K20R, K32E, V35I, K49R, I135V, S162CW, E169D, Q207E, R211K, A272P, I293VB
 CA7052CA17358AF514250AZT, D4T, DDINoneA62V, K65KR, V75I, F77L, Q151M A33V, V35T, S68G, K122E, D123N, I178L, T200A, H221HY, E248D, A272P, Q278QE, I293V, A299AG, A304GB
Dumans (2004)180180AY390156AZT, DDINoneV75I, Y115F, F116Y, Q151M, K219Q S68G, D177E, R211KB
 197197AY390154AZT, DDI, D4T, 3TCNoneA62V, V75I, F77L, F116Y, Q151M, M184V, K219QE138KK49R, I50V, S68G, K101Q, R172K, V179A, I202V, F214LB
 208208AY390155AZT, DDI, 3TC, D4TNoneK65R, K70R, V75I, F77L, Y115F, F116Y, Q151M, K219E S68G, D177EB
Machado (2004)cs157cs157AY313424AZT, DDINoneA62V, V75I, F77L, F116Y, Q151M K122E, I202V, F214LB
Garcia-Bujalance (2005)GBS_31GBS_31AY872366DDC, AZT, 3TCNoneA62V, V75I, M184V E40ED, K43N, A98S, G196E, R211K, V245EB
Mo (2005)91249124_d1 NRTINoneM41L, D67N, T69DN, K70KR, V75I, F77L, F116Y, Q151M, M184V, T215FV, K219Q K20R, S162D, K166R, G196E, I202V, Q207E, R211RK, A272P, K277KR, A288AS, E297EKQB
Non-B Workgroup (2005)TH_146TH_146AY605559AZT, DDINoneV75I, F77L, Y115F, F116Y, Q151M, K219EY188YDE28V, E29R, V35T, T39A, S68G, I135V, S162C, K173I, Q174K, V245RB
Rhee (2005)CA1317CA7990AY800863AZT, DDI, 3TC, D4TNoneV75I, F77L, Y115F, F116Y, Q151M K49R, I50V, S68G, K122E, T200A, E203EQ, Q207E, R211K, K219T, V245T, E248D, D250E, S251X, A272P, K277RB
  CA9386AY800864AZT, DDI, 3TC, D4TNoneV75I, F77L, Y115F, F116Y, Q151M, M184V E40EK, K46KQ, K49R, I50V, S68G, K122E, E169ED, T200A, Q207E, R211K, K219T, V245T, E248D, D250EB
 CA9798CA24062AY802119D4T, 3TCNoneM41ML, K70S, V75I, M184V K20R, S68G, R83K, V90I, I135T, S162C, I178M, G196GE, Q197QE, S251C, K277R, T286A, I293V, R358K, V435I, S468PB
 CA9933CA24557AY802197D4T, DDINoneV75I, F77L, F116Y, Q151MV108VIK20R, V35I, E79ED, R83K, V118I, E203D, F214L, T286A, A288T, E297K, K311KR, S322T, I329L, A376T, K390R, A400T, A437V, E449D, H483HN, K530R, A554SB
Santos (2006)FB109FB109DQ191035AZT, DDI, 3TC, D4TNoneV75I, F77L, T215A T58S, R83K, K122E, K173P, I178L, D192G, T200A, K201Q, Q207E, R211Q, E233A, V245QB
Villena (2007)3670836708-1EF154391D4T, 3TC, DDINoneA62V, K70G, V75I, F77L, Y115F, F116Y, Q151M, M184VY181CK20R, T39A, S68G, T69A, K101R, D123E, I135T, I167V, D177E, I202V, R211K, I293V, P294T, E297K, I375V, T386I, V435I, E449D, D460N, S468P, L491S, K512T, L517I, S519NB
Riddler (2008)RG10828RG10828w66 TDF, 3TCNoneV75I Q197E, R211K, V245M, K281R, I293V, S322T, M357I, A376TB
Rosen-Zvi (2008)5503p55-1 AZT, DDI, DDCNoneA62V, V75I, F77L, Q151M K22N, I50S, V189I, R211K, F214L, T286A, I293V, E297A, E328DB
von Wyl (2010)48147394814739GQ848144AZT, DDINoneV75I, F77L, Y115F, F116Y, Q151M V35I, S68SG, D123E, I135R, K173KQ, A272P, K281KR, T286P, E297K, K311KR, V317A, Q334R, M357T, T369A, I375V, A376T, T377LB