<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype B
Gene RT
Mutation L74V
Rx >= 1 NRTI
(but no NNRTI)
IncludeMixtures No
References 25
Patients 111
Isolates 125
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Ruiz (1996)JCS-C17C17BZ99310DDC, AZTNoneM41L, L74V, L210W, T215YA98GV35I, S68T, R83K, V118I, K122E, D123N, Q207E, R211KB
Hammer (1997)ACTG320_42734273 AZT, DDINoneM41L, L74V, M184V, T215Y, K219KQ I135IT, K166R, K173KE, I195IM, T200TAIV, V245M, T253TN, L260LI, A272P, I293V, V317A, P345Q, K390R, A400T, V435I, A446S, H483YB
 ACTG320_42754275 AZT, DDINoneL74V D123E, T165I, D177E, V245E, K277R, M357T, S379G, T386I, K388KN, K390R, E399D, A400T, T403S, V435I, A446S, D471NB
 ACTG320_842842 AZT, DDINoneD67N, K70R, L74V, K219Q Q197P, F214L, K277R, E297K, R356RK, A376T, A400T, D460N, V466IB
 ACTG320_886886 AZT, DDINoneM41ML, D67DN, K70KR, L74V, T215TFIS, K219KQY181YCV60VIM, K64KHNQ, K104KN, V118VI, D123E, I135T, D177DE, I178IM, G196E, R211G, F214L, D218DE, A272P, K277KR, I293V, K311R, S322T, T338S, M357MT, R358RK, K395R, A400S, E404D, E432ED, V466VA, T470N, D488DEB
 ACTG320_925925 AZT, DDINoneL74V, L210W, T215DY181CS68G, R83K, V90I, D123E, K166KR, I178M, R211K, S251V, K277R, T286A, V292I, D324E, Q334L, K347KR, T377Q, T386TA, K390R, A400L, V435A, K451R, R461RKB
 ACTG320_9696 AZT, DDC, DDINoneM41L, L74V, L210LW, T215Y V60VI, E138A, S162C, T200E, E248D, I293V, I326V, A360T, T403L, V435A, G436E, N447S, V458I, H483YB
Winters (1997)143P1143P1W88AF013423DDINoneL74V, M184V D121H, K122E, I135T, S162C, D177E, R211KB
 143P4143P4W104AF013431DDINoneL74V D123E, S162C, T200M, Q207E, R211KB
 143P5143P5W72AF013435DDINoneL74VV179VDA98S, K122E, R211KB
 143P6143P6W88AF013437DDINoneL74V V106I, D123E, I135T, S162W, D177EB
 143P8143P8W104AF013441DDINoneL74V V60I, R83K, K166R, R211KB
 143P2143P2W88AF013445DDINoneL74V, M184V R83K, S162A, R211AB
 143P9143P9W104AF013447AZT, DDINoneL74V K122E, K173Q, I178M, Q207EB
 143P3143P3W104AF013449AZT, DDINoneL74V, M184V R83K, D123E, S162A, T200IB
 143P11143P11W72AF013451AZT, DDINoneK65R, K70R, L74V, K219KQ D121H, K122E, I142V, R172RK, Q174QP, I178M, V179I, R211K, K238KIB
 143P10143P10W56AF013457AZT, DDINoneM41L, L74V, L210W, T215Y K49R, R83K, V90I, S162D, R211K, K220KTB
Cabana (1999)Cab-hH0AF102353AZT, DDINoneM41L, L74V, L210W, T215Y I135T, S162C, R211KB
Deeks (1999)SD-7SD-7AF124545NRTI, 3TC, DDINoneL74V, M184V K122E, K173R, Q174K, I178M, Q207E, A272P, T286AB
Balotta (2000)CB-197CB-197AF252050AZT, DDINoneM41L, K70G, L74V, T215Y K122E, D123E, I135T, S162C, I178M, G196EB
 CB-295CB-295AF252011AZT, D4T, 3TC, DDINoneM41L, A62V, L74V, M184V V35I, S48T, D123E, G196GDE, T200AB
Baxter (2000)GART-G93GART-93 NRTI, 3TC, D4TNoneM41L, L74V, M184V, T215Y T39A, E40EQ, A98S, T107P, K122E, I142V, D177E, T200A, E203E*, R211KB
Miller (2000)MV-116MV-116wk24 ABCNoneL74V, M184V V35I, R83K, D123E, I135T, T200IB
 MV-122MV-122wk24 ABCNoneL74V, Y115F, M184V F87FL, D123E, A158S, F160FP, S162C, M164MV, R172T, Q197HG, E203D, Q207E, F214XB
 MV-127MV-127wk24 ABCNoneL74V, M184V V118I, K122E, D123E, K173R, I180V, T200A, E204K, Q207E, R211K, F214LB
 MV-128MV-128wk16 ABCNoneL74V, M184V K32Q, A98S, K102Q, I135R, R211KB
 MV-148MV-148wk16 ABCNoneL74V, M184V S162A, K166KR, Q174H, I178M, R199RK, E203EK, R206RK, Q207H, R211KB
 MV-157MV-157wk24 ABCNoneL74V F87FL, Q161HG, E169EK, Q174H, Q207E, R211KB
 MV-162MV-162wk16 ABCNoneL74V V35I, K122E, A158AT, E169EK, D177E, Q207E, R211KB
  MV-162wk24 ABCNoneL74V, M184V I37F, C38V, T39X, N54I, K122E, D177E, Q207E, R211KB
 MV-167MV-167wk12 ABCNoneL74V, M184V V106VI, K122E, S162C, E169D, R211KB
  MV-167wk48 ABC, AZT, 3TCNoneL74V, Y115F, M184V I31V, K122E, S162C, E169D, R211KB
 MV-168MV-168wk36 ABC, AZT, 3TCNoneL74V, Y115F, M184V V35I, S68G, K122E, I135T, G196E, E204DB
 MV-178MV-178wk16 ABCNoneL74V, M184MV I47X, D123E, F130FI, I135T, S162A, E169EK, D177E, T200A, R211KB
 MV-196MV-196wk16 ABCNoneL74V, M184V K122E, D123S, I159VB
  MV-196wk24 ABCNoneL74V, M184MV K122E, D123S, I159VB
 MV-198MV-198wk12 ABCNoneL74V, M184V D123E, K154KN, A158T, E169EK, D177E, I178L, R199RI, I202X, R211RK, F214FL, D218XB
  MV-198wk24 ABCNoneL74V, Y115F, M184V D123E, I142X, R143X, Y144XB
 MV-205MV-205wk24 ABCNoneL74V, M184V V60I, R83K, I135T, Q145X, Y146X, A158T, K166R, R199RK, T216PB
 MV-751MV-751wk24 ABCNoneK70R, L74V, M184V, T215D K49R, V60I, K122E, I135T, A158AT, E169EK, G196R, R211KB
Parkin (2000)SD-7SD-7_8AF294525NRTI, 3TC, DDI, DDC, ABCNoneL74V, M184V P4PS, K122E, Q174K, I178M, Q207E, R211A, Q222QR, T240S, A272P, T286AB
  SD-7_16AF294526NRTI, 3TC, DDI, DDC, ABCNoneL74V, M184V P4PS, I5IV, K122E, Q174K, I178M, Q207E, R211RG, T240TS, A272P, T286AB
  SD-7_36AF294527NRTI, 3TC, DDI, DDC, ABCNoneL74V, M184V P4S, K20KR, K122E, Q174K, I178M, Q207E, R211A, T240TS, A272P, T286AB
Albrecht (2001)ACTG364_22532253 DDI, AZT, 3TCNoneM41L, L74V, M184V, L210W, T215Y I31L, E36EA, T39TS, K43EQ, E44EA, K49R, V60VI, I135M, V245M, E297KB
 ACTG364_28662866 DDI, AZT, 3TCNoneM41ML, A62AV, K70KR, L74V, V75T, M184V I31IL, I37IL, V90I, I135LM, S162A, Q197R, V245M, A288S, I293V, E297KB
 ACTG364_33113311 DDI, AZT, 3TCNoneM41L, L74V, M184V, T215F I31L, V60I, K122E, D123E, I178M, V179I, G196E, R211K, A272S, T286AB
 ACTG364_43594359 AZT, DDINoneM41L, D67N, K70R, L74V, L210LW, T215Y, K219KQ K64N, R83G, Q207E, R211K, V245M, K277RB
 ACTG364_52635263 DDI, AZT, 3TCNoneM41L, L74V, M184V K11KR, D123E, I178M, Q207E, V245E, A272P, I274IV, I293VB
 ACTG364_903903 AZT, DDCNoneL74V, M184V I31L, V35I, R83RG, Q85QP, K122E, I135T, N136NS, I142IN, Y144YC, S162Y, I178M, S251IB
Eshleman (2001)A005AF357609AF357609AZT, DDINoneL74V K49R, R83K, K122E, D123DE, I178M, T200TI, I202IV, R211RK, V245E, K249Q, A272P, K277R, K281R, E297KB
 A014AF357618AF357618AZT, DDINoneM41L, L74V, T215Y, K219KQ K64KN, R83K, V118I, D123E, I178L, R211K, F214L, V245M, K249KR, A272P, K281R, E297K, V317EB
 A029AF357632AF357632AZT, DDINoneL74V V35VI, T165I, Q174QR, I178L, F214L, V245E, I293VB
 A035AF357638AF357638AZT, DDINoneL74V V35L, R83RK, D123E, I178M, G196E, V245L, A272P, K275R, V276I, K277R, Q278N, T286A, T296S, E297K, S322AB
 A043AF357645AF357645AZT, DDINoneM41L, L74V, V75T, K219Q G18C, K64R, V106VI, V118I, K122KT, D123E, I142T, D177E, I178M, R211K, F214L, L228H, V245VM, E248ED, D250DE, E291D, E297KB
 A051AF357652AF357652AZT, DDINoneL74V K32D, V118I, D123E, I135R, E138G, S162D, N175Y, H198N, F214L, A272P, K277R, T286A, E297KB
 A058AF357659AF357659AZT, DDINoneL74V R83K, K104R, D123E, S162A, I178M, T200A, V245E, A272P, K277R, E297KB
 A073AF357674AF357674AZT, DDINoneL74V, M184MV V35I, T39K, K43Q, R83K, K102Q, D123E, D177E, T200A, R211RK, A272S, K281R, T286A, I293V, E297KB
 A076AF357677AF357677AZT, DDINoneL74VV108VIV35I, R83K, D121H, K122E, E169D, D177DE, I178LM, K249Q, A272P, K281R, T286P, E297KB
 A078AF357679AF357679AZT, DDINoneL74V V35I, R83K, K122E, D123N, I178M, T200TA, K249Q, A272S, K281R, I293V, E297KB
 A079AF357680AF357680AZT, DDINoneL74VV179VDV35VI, E248N, A272P, K281KR, E291D, E297KTB
 A092AF357693AF357693AZT, DDINoneL74V D123E, I178M, P243PS, V245VM, E248D, A272P, K281KR, T286A, E297KB
 A094AF357695AF357695AZT, DDINoneL74V, M184V V35T, T69S, K104N, I142V, T200A, F214L, D250E, E297KB
 A107AF357708AF357708AZT, DDINoneL74V V8I, R83K, D123E, I135T, T200A, E248N, A272S, V276I, K281RB
 A132AF357730AF357730AZT, DDINoneL74V V35IL, R83K, V106VI, K122E, G196E, E248D, A272P, I274V, K275R, Q278N, K281KR, E297K, V314IB
 A139AF357737AF357737AZT, DDINoneL74V D177DN, R211G, F214L, V245I, E248D, D250E, K281R, I293VB
  AF357796AF357796AZT, DDI, D4T, 3TCNoneL74V D177N, R211G, F214L, V245I, E248D, D250E, K281R, I293VB
Gonzales (2001)CA1453CA3879AY030589AZT, DDINoneM41L, L74V K11KR, R83K, K122E, I142V, S162SN, K166R, G196E, F214FL, A272S, K277KR, T286AB
 CA1487CA4258AY030613AZT, DDI, D4T, 3TCNoneM41L, A62AV, L74V, M184V, L210W, T215Y S68SR, V118VI, K122E, R143RT, Q197QH, T200TI, R211K, K223KNB
 CA1821CA4903AY030735AZT, DDC, D4T, 3TC, DDINoneM41L, L74V, M184V, L210W, T215Y K20R, K122E, S162AB
 CA1847CA4954AY030752DDI, AZTNoneM41L, D67N, T69D, K70R, L74V, T215F, K219Q A33AG, V60I, K103R, V118I, K122E, I135T, I159L, K166T, E194EA, I202IT, H208HY, F214L, D218DEB
 CA3959CA9190AY030957DDI, 3TCNoneL74V, M184V, T215Y K11KR, K20R, V35M, K43E, S68G, R83K, K122P, I135V, G196E, T200IB
 CA4082CA9369AY031076AZT, 3TC, D4T, DDINoneM41L, D67N, K70R, L74V, V75S, T215F, K219Q K64NY, V118I, K122E, I135T, R172K, F214L, D218E, A288SB
 CA4398CA10604AY031256DDC, 3TC, D4TNoneM41L, L74V, M184V, L210W, T215Y S68G, E79EG, Q85QP, K122E, T131TP, I135T, N137NS, Y146YS, S162A, I178M, Q207E, R211KB
 CA4724CA11586AY0313863TC, DDINoneL74V, M184V E53D, V60I, D121Y, K122E, D177E, I178M, G196E, T200S, R211K, A272P, T286A, E297KB
 CA5158CA12453AY031724AZT, D4T, 3TC, DDINoneM41L, D67N, L74V, M184V, L210W, T215Y E28K, K32E, T39TA, K43KN, E44D, V118I, K122E, I135V, S162C, I178M, R211K, K223Q, K277R, I293VB
 CA5271CA12930AY031828AZT, DDI, 3TCNoneT69G, K70R, L74V, T215F, K219Q D67X, A98S, I135V, D192E, R211K, L228H, V245T, K277R, L283I, I293VB
 CA6449CA15964AY032402AZT, DDI, D4T, 3TCNoneK70R, L74V, M184V, K219Q E6D, K64R, T69N, Q207E, F214L, A272PB
Katzenstein (2001)ACTG302_10621062RT_bl DDINoneL74V V35I, K122KE, I135T, S162C, I178M, S251IB
 ACTG302_14441444RT_f1 DDI, AZT, 3TCNoneA62V, L74V, V75T, M184V I37L, V90I, I135M, S162A, Q197R, V245M, A288S, I293V, E297KB
 ACTG302_15211521RT_bl DDINoneL74V, M184V W24WC, K49R, T107P, D177DE, V241VE, V245M, K275KN, T286N, K287KN, E297KB
  1521RT_f1 DDI, AZT, 3TCNoneL74V, M184V, T215Y I31L, K49R, K102R, V118I, K122R, V245M, E297K, E300ED, L301LV, E302E*B
 ACTG302_18941894RT_bl DDINoneL74V I142T, E194K, R211K, F214L, K223KR, K281R, I293V, E297KB
 ACTG302_19551955RT_bl DDINoneL74VY181CK122E, I135T, Q174H, G196E, I202V, Q207E, R211K, H221Y, A272PB
 ACTG302_20902090RT_bl AZT, DDINoneM41L, L74V, T215Y T39A, R83K, D123E, I142IM, D177E, I178LM, G196GE, A272P, K277R, I293VB
 ACTG302_20982098RT_bl AZT, DDINoneL74VY181CT7P, R83K, V90I, K122P, S162C, I178M, H221Y, A272P, I293V, P294T, E302DB
 ACTG302_20992099RT_bl DDINoneL74V T27S, I135T, I178M, R211K, V292VGB
 ACTG302_26572657RT_bl DDINoneL74V, L210W K103R, K122P, F171FY, I178M, G196E, R211RK, F214LB
  2657RT_f1 DDI, AZT, 3TCNoneM41L, L74V, M184V, L210LW E79EK, K103KR, K122P, I178M, E204A, F214L, K277R, T286A, E297AB
 ACTG302_29502950RT_bl AZT, DDINoneL74V, M184V K11R, R83K, K122E, N147NY, K166R, G196E, A272S, T286AB
  2950RT_f1 AZT, DDI, 3TCNoneM41L, L74V, M184V K11KR, R83K, K122E, S162SN, K166R, G196E, A272S, T286A, I293IL, E297K, A299AGB
 ACTG302_30443044RT_bl AZT, DDINoneM41L, L74V, T215YV179VDK20R, E28E*, T39TA, E53ED, K122E, I178M, T200TI, Q207E, R211Q, V245M, A272P, L283I, I293VB
 ACTG302_33293329RT_bl DDINoneL74V, M184MV T107TP, Y146YC, Q174H, H198HR, R211RK, F214L, W239WC, K277R, K287KN, I293VB
 ACTG302_35863586RT_bl DDINoneL74V, M184V A98APS, I135T, S162A, R211K, T286A, V292I, E297KB
 ACTG302_36203620RT_bl AZT, DDINoneD67N, K70R, L74V, V75T, K219Q V35I, R83K, K104N, D123E, S162C, I178L, G196E, Q207R, F214FL, A272P, K277RB
 ACTG302_806806RT_bl AZT, DDINoneL74V R83K, K122P, I135T, S162A, T165I, D177E, G196E, A272P, K277R, E297KB
  806RT_f1 AZT, DDI, 3TCNoneA62AV, L74V, M184V I31IL, E44ED, R83K, K122P, I135T, S162A, T165I, D177E, G196E, F214FL, A272PB
Ait-Khaled (2002)MAK-16091609481AJ425964ABC, AZT, 3TC, D4TNoneM41L, D67N, L74V, L210W, T215Y, K219NA98AG, K101KE, Y181C, Y188L, G190GAT39K, K43E, E44D, V118I, K122E, V179I, E203K, H208Y, R211K, K223E, P226SB
 MAK-17001700481AJ425986ABC, AZT, 3TCNoneL74V, M184V K20R, V35I, K64KR, D86S, K101Q, K103R, I135K, K173E, Q174R, R211KB
Gibb (2002)DMG3939_w44 ABC, 3TCNoneK65KR, L74V, M184V D123E, S162C, I178IM, R211K, V245VE, A272P, I293V, E297K, L310I, V317VA, M357T, T369A, I375VB
 DMG4949_w32 ABC, 3TCNoneL74V, Y115YF, M184V K122KPQT, D123E, I180IV, Q207E, R211K, A272P, K275R, K277R, Q278H, A288AS, I293IV, E297K, I329L, Q334E, M357T, A360T, A376T, K390R, E396DB
 DMG6363_w27 ABC, AZTNoneL74V, M184V K122KRT, D123E, I180IV, Q207E, R211K, A272P, K275R, K277R, Q278H, R284RK, K287K*, A288AS, I293IV, E297K, I329L, Q334E, M357T, A360T, A376T, K390R, E396DB
Naugler (2002)WES-1HIV1ESAF422723AZT, DDINoneL74VK103N, Y181CA33V, V35T, T69N, R83K, D123EB
 WES-2HIV2ESAF422724AZT, DDINoneK70R, L74V, T215Y V35I, D123E, S162C, D177E, R211KB
 WES-6HIV6ESAF422728AZT, DDINoneL74V, T215Y V35I, T39S, R83K, D121Y, K122E, A158S, D177E, G196EB
 WES-17HIV17ESAF422739AZT, DDINoneM41L, L74V, L210W, T215Y T39P, S68G, R83K, D123E, G196S, R211KB
 WES-22HIV22ESAF422744AZT, DDINoneK70R, L74V, T215F T69N, R83K, D177EB
 WES-23HIV23ESAF422745AZT, DDINoneM41L, L74V, L210W, T215Y V35I, R83K, I135T, G196E, R211KB
Tural (2002)881309881309 DDC, AZT, 3TC, DDINoneL74V, M184V V8I, V35M, T39A, V60I, R83K, D123E, I135T, T200A, R211KB
Monno (2003)ML_pt10ML131AY267789AZT, D4T, 3TC, DDINoneM41L, L74V, M184V, T215Y K20KR, K32R, S162C, D177E, R211KB
Roge (2003)so7so7-F1AY222065ABC, D4T, DDINoneM41L, D67N, L74V, L210W, T215Y, K219R V60I, L120I, E204Q, R211K, D218EB
  so7-F2AY222066ABC, D4T, DDINoneM41L, D67N, L74V, L210W, T215Y, K219R V60I, K64N, R72RK, E204Q, R211K, D218EB
Montes (2004)MB_patSEGU00_SEGE704AJ578157ABC, 3TC, D4T, DDC, AZT, DDINoneM41L, D67N, L74V, M184V, L210W, T215Y K102Q, K122P, I135V, I142V, S162C, I178L, V179I, K238RB
 MB_patCAS00_CASE717AJ577859DDC, AZT, 3TC, D4T, DDI, ABCNoneM41L, D67N, T69D, L74V, L210W, T215YK103NE6D, T39K, K43E, E44D, V60I, V118I, K122P, D123E, I135T, S162N, K173T, D177E, G196D, E203K, Q207E, H208Y, R211K, K223QB
Non-B Workgroup (2005)BR8BR8 AZT, DDI, 3TC, D4TNoneM41L, D67N, L74V, L210W, T215Y, K219R K20R, K32R, T39S, V60I, V90I, V118I, I142V, E169D, H208Y, R211K, K223QB
Rhee (2005)SWC-3692P3692-978 AZT, 3TC, D4T, DDINoneL74V, M184V, L210W R211KB
 SWC-5577P5577-906 AZT, D4T, DDC, 3TCNoneM41L, L74V, M184V, L210W, T215Y K122E, I135V, S162G, E203D, Q207D, R211KB
 CA4724CA11972AY8013803TC, DDINoneL74V, M184V E53D, V60I, D121Y, K122E, R143RS, D177E, I178M, G196E, T200S, I202IL, R211K, K220KI, A272P, K275KN, T286A, I293YB
 CA5135CA38035AY801491AZT, 3TC, ABC, DDINoneL74V, M184V E6K, K122E, A272S, R284K, I293VB
 CA6876CA16949AY801727AZT, DDI, D4T, 3TCNoneM41L, D67N, L74V, M184V, L210W, T215Y K20KR, K22KN, K43Q, V118I, K122E, S134SG, I135IR, I142V, E169D, H208Y, R211K, D218E, Q242QE, K277R, T286A, E297Q, A304GB
 SWC-11331133-4246 3TC, D4T, ABC, DDINoneL74V, M184V R83K, K173R, Q174K, Q207E, R211K, I257LB
 CA16482CA39152AY802518DDI, 3TCNoneL74V, M184V S68G, A98S, V118VI, G196E, R211K, V245E, A272S, A288ST, I293V, E297KRB
 CA18383CA42914AY802557D4T, DDINoneM41L, L74V, L210W, T215YK101EK32N, V35T, K49KR, S68G, V118I, K122E, D123E, I135R, D177E, I178L, E203DN, Q207E, R211K, K223KQ, V245K, E297TB
Rhee (2009)CA14413CA34690FJ9833723TC, DDINoneL74V, M184V S68SG, R83RK, K102Q, I135M, S162A, E169D, Q207E, A272P, K277R, M357T, S379G, K431T, S519N, V531I, A534TB
Kim (2013)Tx16294KC120883ABC, D4TNoneM41L, L74V, M184V, L210W, T215YK101P, K103SK43Q, V118I, K122E, S162Y, D177E, I178M, T200R, E203A, Q207E, R211K, K223Q, L228H, V245IM, A272P, I293V, E312TB
Steegen (2014)12ZAKS34012ZAKS340KJ176619D4T, 3TCNoneM41L, A62V, D67N, L74V, M184L, L210W, T215Y, N348IL100I, K103NP4PS, K20R, V35M, E44D, K102KR, T107S, L109I, I135T, S162C, V189I, Q197K, T200A, I202T, H208Y, R211K, H221Y, A272S, K277R, A288S, I293V, E297EK, E312EQ, S322A, Q334E, I341F, R356K, T386V, K390RB