Reverse Transcriptase Inhibitors

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Reverse Transcriptase Inhibitors

Subtype	B
Gene	RT
Mutation	L74V
Rx	>= 1 NRTI (but no NNRTI)
IncludeMixtures	No

References	23
Patients	107
Isolates	121

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	NRTIs	NNRTIs	NRTIDRMs	NNRTIDRMs	OtherMut	Subtype
Ruiz (1996)	JCS-C17	C17B	Z99310	DDC, AZT	None	M41L, L74V, L210W, T215Y	A98G	V35I, S68T, R83K, V118I, K122E, D123N, Q207E, R211K	B
Hammer (1997)	ACTG320_4273	4273		AZT, DDI	None	M41L, L74V, M184V, T215Y, K219KQ		I135IT, K166R, K173KE, I195IM, T200TAIV, V245M, T253TN, L260LI, A272P, I293V, V317A, P345Q, K390R, A400T, V435I, A446S, H483Y	B
	ACTG320_4275	4275		AZT, DDI	None	L74V		D123E, T165I, D177E, V245E, K277R, M357T, S379G, T386I, K388KN, K390R, E399D, A400T, T403S, V435I, A446S, D471N	B
	ACTG320_842	842		AZT, DDI	None	D67N, K70R, L74V, K219Q		Q197P, F214L, K277R, E297K, R356RK, A376T, A400T, D460N, V466I	B
	ACTG320_886	886		AZT, DDI	None	M41ML, D67DN, K70KR, L74V, T215TFIS, K219KQ	Y181YC	V60VIM, K64KHNQ, K104KN, V118VI, D123E, I135T, D177DE, I178IM, G196E, R211G, F214L, D218DE, A272P, K277KR, I293V, K311R, S322T, T338S, M357MT, R358RK, K395R, A400S, E404D, E432ED, V466VA, T470N, D488X	B
	ACTG320_925	925		AZT, DDI	None	L74V, L210W, T215D	Y181C	S68G, R83K, V90I, D123E, K166KR, I178M, R211K, S251V, K277R, T286A, V292I, D324E, Q334L, K347KR, T377Q, T386TA, K390R, A400L, V435A, K451R, R461RK	B
	ACTG320_96	96		AZT, DDC, DDI	None	M41L, L74V, L210LW, T215Y		V60VI, E138A, S162C, T200E, E248D, I293V, I326V, A360T, T403L, V435A, G436E, N447S, V458I, H483Y	B
Winters (1997)	143P1	143P1W88	AF013423	DDI	None	L74V, M184V		D121H, K122E, I135T, S162C, D177E, R211K	B
	143P4	143P4W104	AF013431	DDI	None	L74V		D123E, S162C, T200M, Q207E, R211K	B
	143P5	143P5W72	AF013435	DDI	None	L74V		A98S, K122E, V179X, R211K	B
	143P6	143P6W88	AF013437	DDI	None	L74V		V106I, D123E, I135T, S162W, D177E	B
	143P8	143P8W104	AF013441	DDI	None	L74V		V60I, R83K, K166R, R211K	B
	143P2	143P2W88	AF013445	DDI	None	L74V, M184V		R83K, S162A, R211A	B
	143P9	143P9W104	AF013447	AZT, DDI	None	L74V		K122E, K173Q, I178M, Q207E	B
	143P3	143P3W104	AF013449	AZT, DDI	None	L74V, M184V		R83K, D123E, S162A, T200I	B
	143P11	143P11W72	AF013451	AZT, DDI	None	K65R, K70R, L74V, K219KQ		D121H, K122E, I142V, R172X, Q174X, I178M, V179I, R211K, K238X	B
	143P10	143P10W56	AF013457	AZT, DDI	None	M41L, L74V, L210W, T215Y		K49R, R83K, V90I, S162D, R211K, K220KT	B
Cabana (1999)	Cab-h	H0	AF102353	AZT, DDI	None	M41L, L74V, L210W, T215Y		I135T, S162C, R211K	B
Deeks (1999)	SD-7	SD-7	AF124545	NRTI, 3TC, DDI	None	L74V, M184V		K122E, K173R, Q174K, I178M, Q207E, A272P, T286A	B
Balotta (2000)	CB-197	CB-197	AF252050	AZT, DDI	None	M41L, K70G, L74V, T215Y		K122E, D123E, I135T, S162C, I178M, G196E	B
	CB-295	CB-295	AF252011	AZT, D4T, 3TC, DDI	None	M41L, A62V, L74V, M184V		V35I, S48T, D123E, G196GDE, T200A	B
Baxter (2000)	GART-G93	GART-93		NRTI, 3TC, D4T	None	M41L, L74V, M184V, T215Y		T39A, E40EQ, A98S, T107P, K122E, I142V, D177E, T200A, E203X, R211K	B
Miller (2000)	MV-116	MV-116wk24		ABC	None	L74V, M184V		V35I, R83K, D123E, I135T, T200I	B
	MV-127	MV-127wk24		ABC	None	L74V, M184V		V118I, K122E, D123E, K173R, I180V, T200A, E204K, Q207E, R211K, F214L	B
	MV-128	MV-128wk16		ABC	None	L74V, M184V		K32Q, A98S, K102Q, I135R, R211K	B
	MV-148	MV-148wk16		ABC	None	L74V, M184V		S162A, K166KR, Q174H, I178M, R199RK, E203EK, R206RK, Q207H, R211K	B
	MV-157	MV-157wk24		ABC	None	L74V		F87FL, Q161HG, E169EK, Q174H, Q207E, R211K	B
	MV-162	MV-162wk16		ABC	None	L74V		V35I, K122E, A158AT, E169EK, D177E, Q207E, R211K	B
		MV-162wk24		ABC	None	L74V, M184V		I37F, C38V, T39X, N54I, K122E, D177E, Q207E, R211K	B
	MV-167	MV-167wk12		ABC	None	L74V, M184V		V106VI, K122E, S162C, E169D, R211K	B
		MV-167wk48		ABC, AZT, 3TC	None	L74V, Y115F, M184V		I31V, K122E, S162C, E169D, R211K	B
	MV-168	MV-168wk36		ABC, AZT, 3TC	None	L74V, Y115F, M184V		V35I, S68G, K122E, I135T, G196E, E204D	B
	MV-178	MV-178wk16		ABC	None	L74V, M184MV		I47X, D123E, F130FI, I135T, S162A, E169EK, D177E, T200A, R211K	B
	MV-196	MV-196wk16		ABC	None	L74V, M184V		K122E, D123S, I159V	B
		MV-196wk24		ABC	None	L74V, M184MV		K122E, D123S, I159V	B
	MV-198	MV-198wk12		ABC	None	L74V, M184V		D123E, K154KN, A158T, E169EK, D177E, I178L, R199RI, I202X, R211RK, F214FL, D218X	B
		MV-198wk24		ABC	None	L74V, Y115F, M184V		D123E, I142X, R143X, Y144X	B
	MV-205	MV-205wk24		ABC	None	L74V, M184V		V60I, R83K, I135T, Q145X, Y146X, A158T, K166R, R199RK, T216P	B
	MV-751	MV-751wk24		ABC	None	K70R, L74V, M184V, T215D		K49R, V60I, K122E, I135T, A158AT, E169EK, G196R, R211K	B
Parkin (2000)	SD-7	SD-7_8	AF294525	NRTI, 3TC, DDI, DDC, ABC	None	L74V, M184V		P4PS, K122E, Q174K, I178M, Q207E, R211A, Q222QR, T240S, A272P, T286A	B
		SD-7_16	AF294526	NRTI, 3TC, DDI, DDC, ABC	None	L74V, M184V		P4PS, I5IV, K122E, Q174K, I178M, Q207E, R211RG, T240TS, A272P, T286A	B
		SD-7_36	AF294527	NRTI, 3TC, DDI, DDC, ABC	None	L74V, M184V		P4S, K20KR, K122E, Q174K, I178M, Q207E, R211A, T240TS, A272P, T286A	B
Albrecht (2001)	ACTG364_2253	2253		DDI, AZT, 3TC	None	M41L, L74V, M184V, L210W, T215Y		I31L, E36EA, T39TS, K43EQ, E44EA, K49R, V60VI, I135M, V245M, E297K	B
	ACTG364_2866	2866		DDI, AZT, 3TC	None	M41ML, A62AV, K70KR, L74V, V75T, M184V		I31IL, I37IL, V90I, I135LM, S162A, Q197R, V245M, A288S, I293V, E297K	B
	ACTG364_3311	3311		DDI, AZT, 3TC	None	M41L, L74V, M184V, T215F		I31L, V60I, K122E, D123E, I178M, V179I, G196E, R211K, A272S, T286A	B
	ACTG364_4359	4359		AZT, DDI	None	M41L, D67N, K70R, L74V, L210LW, T215Y, K219KQ		K64N, R83G, Q207E, R211K, V245M, K277R	B
	ACTG364_5263	5263		DDI, AZT, 3TC	None	M41L, L74V, M184V		K11KR, D123E, I178M, Q207E, V245E, A272P, I274IV, I293V	B
	ACTG364_903	903		AZT, DDC	None	L74V, M184V		I31L, V35I, R83RG, Q85QP, K122E, I135T, N136NS, I142IN, Y144YC, S162Y, I178M, S251I	B
Eshleman (2001)	A005	AF357609	AF357609	AZT, DDI	None	L74V		K49R, R83K, K122E, D123DE, I178M, T200TI, I202IV, R211RK, V245E, K249Q, A272P, K277R, K281R, E297K	B
	A014	AF357618	AF357618	AZT, DDI	None	M41L, L74V, T215Y, K219KQ		K64KN, R83K, V118I, D123E, I178L, R211K, F214L, V245M, K249KR, A272P, K281R, E297K, V317E	B
	A029	AF357632	AF357632	AZT, DDI	None	L74V		V35VI, T165I, Q174QR, I178L, F214L, V245E, I293V	B
	A035	AF357638	AF357638	AZT, DDI	None	L74V		V35L, R83RK, D123E, I178M, G196E, V245L, A272P, K275R, V276I, K277R, Q278N, T286A, T296S, E297K, S322A	B
	A043	AF357645	AF357645	AZT, DDI	None	M41L, L74V, V75T, K219Q		G18C, K64R, V106VI, V118I, K122KT, D123E, I142T, D177E, I178M, R211K, F214L, L228H, V245VM, E248ED, D250DE, E291D, E297K	B
	A051	AF357652	AF357652	AZT, DDI	None	L74V		K32D, V118I, D123E, I135R, E138G, S162D, N175Y, H198N, F214L, A272P, K277R, T286A, E297K	B
	A058	AF357659	AF357659	AZT, DDI	None	L74V		R83K, K104R, D123E, S162A, I178M, T200A, V245E, A272P, K277R, E297K	B
	A073	AF357674	AF357674	AZT, DDI	None	L74V, M184MV		V35I, T39K, K43Q, R83K, K102Q, D123E, D177E, T200A, R211RK, A272S, K281R, T286A, I293V, E297K	B
	A076	AF357677	AF357677	AZT, DDI	None	L74V	V108VI	V35I, R83K, D121H, K122E, E169D, D177DE, I178LM, K249Q, A272P, K281R, T286P, E297K	B
	A078	AF357679	AF357679	AZT, DDI	None	L74V		V35I, R83K, K122E, D123N, I178M, T200TA, K249Q, A272S, K281R, I293V, E297K	B
	A079	AF357680	AF357680	AZT, DDI	None	L74V	V179VD	V35VI, E248N, A272P, K281KR, E291D, E297KT	B
	A092	AF357693	AF357693	AZT, DDI	None	L74V		D123E, I178M, P243PS, V245VM, E248D, A272P, K281KR, T286A, E297K	B
	A094	AF357695	AF357695	AZT, DDI	None	L74V, M184V		V35T, T69S, K104N, I142V, T200A, F214L, D250E, E297K	B
	A107	AF357708	AF357708	AZT, DDI	None	L74V		V8I, R83K, D123E, I135T, T200A, E248N, A272S, V276I, K281R	B
	A132	AF357730	AF357730	AZT, DDI	None	L74V		V35IL, R83K, V106VI, K122E, G196E, E248D, A272P, I274V, K275R, Q278N, K281KR, E297K, V314I	B
	A139	AF357737	AF357737	AZT, DDI	None	L74V		D177DN, R211G, F214L, V245I, E248D, D250E, K281R, I293V	B
		AF357796	AF357796	AZT, DDI, D4T, 3TC	None	L74V		D177N, R211G, F214L, V245I, E248D, D250E, K281R, I293V	B
Gonzales (2001)	CA1453	CA3879	AY030589	AZT, DDI	None	M41L, L74V		K11KR, R83K, K122E, I142V, S162SN, K166R, G196E, F214FL, A272S, K277KR, T286A	B
	CA1487	CA4258	AY030613	AZT, DDI, D4T, 3TC	None	M41L, A62AV, L74V, M184V, L210W, T215Y		S68SR, V118VI, K122E, R143RT, Q197QH, T200TI, R211K, K223KN	B
	CA1821	CA4903	AY030735	AZT, DDC, D4T, 3TC, DDI	None	M41L, L74V, M184V, L210W, T215Y		K20R, K122E, S162A	B
	CA1847	CA4954	AY030752	DDI, AZT	None	M41L, D67N, T69D, K70R, L74V, T215F, K219Q		A33AG, V60I, K103R, V118I, K122E, I135T, I159L, K166T, E194EA, I202IT, H208HY, F214L, D218DE	B
	CA3959	CA9190	AY030957	DDI, 3TC	None	L74V, M184V, T215Y		K11KR, K20R, V35M, K43E, S68G, R83K, K122P, I135V, G196E, T200I	B
	CA4082	CA9369	AY031076	AZT, 3TC, D4T, DDI	None	M41L, D67N, K70R, L74V, V75S, T215F, K219Q		K64NY, V118I, K122E, I135T, R172K, F214L, D218E, A288S	B
	CA4398	CA10604	AY031256	DDC, 3TC, D4T	None	M41L, L74V, M184V, L210W, T215Y		S68G, E79EG, Q85QP, K122E, T131TP, I135T, N137NS, Y146YS, S162A, I178M, Q207E, R211K	B
	CA4724	CA11586	AY031386	3TC, DDI	None	L74V, M184V		E53D, V60I, D121Y, K122E, D177E, I178M, G196E, T200S, R211K, A272P, T286A, E297K	B
	CA5158	CA12453	AY031724	AZT, D4T, 3TC, DDI	None	M41L, D67N, L74V, M184V, L210W, T215Y		E28K, K32E, T39TA, K43KN, E44D, V118I, K122E, I135V, S162C, I178M, R211K, K223Q, K277R, I293V	B
	CA5271	CA12930	AY031828	AZT, DDI, 3TC	None	T69G, K70R, L74V, T215F, K219Q		D67X, A98S, I135V, D192E, R211K, L228H, V245T, K277R, L283I, I293V	B
	CA6449	CA15964	AY032402	AZT, DDI, D4T, 3TC	None	K70R, L74V, M184V, K219Q		E6D, K64R, T69N, Q207E, F214L, A272P	B
Katzenstein (2001)	ACTG302_1062	1062RT_bl		DDI	None	L74V		V35I, K122KE, I135T, S162C, I178M, S251I	B
	ACTG302_1444	1444RT_f1		DDI, AZT, 3TC	None	A62V, L74V, V75T, M184V		I37L, V90I, I135M, S162A, Q197R, V245M, A288S, I293V, E297K	B
	ACTG302_1521	1521RT_bl		DDI	None	L74V, M184V		W24WC, K49R, T107P, D177DE, V241VE, V245M, K275KN, T286N, K287KN, E297K	B
		1521RT_f1		DDI, AZT, 3TC	None	L74V, M184V, T215Y		I31L, K49R, K102R, V118I, K122R, V245M, E297K, E300ED, L301LV, E302E*	B
	ACTG302_1894	1894RT_bl		DDI	None	L74V		I142T, E194K, R211K, F214L, K223KR, K281R, I293V, E297K	B
	ACTG302_1955	1955RT_bl		DDI	None	L74V	Y181C	K122E, I135T, Q174H, G196E, I202V, Q207E, R211K, H221Y, A272P	B
	ACTG302_2090	2090RT_bl		AZT, DDI	None	M41L, L74V, T215Y		T39A, R83K, D123E, I142IM, D177E, I178LM, G196GE, A272P, K277R, I293V	B
	ACTG302_2098	2098RT_bl		AZT, DDI	None	L74V	Y181C	T7P, R83K, V90I, K122P, S162C, I178M, H221Y, A272P, I293V, P294T, E302D	B
	ACTG302_2099	2099RT_bl		DDI	None	L74V		T27S, I135T, I178M, R211K, V292VG	B
	ACTG302_2657	2657RT_bl		DDI	None	L74V, L210W		K103R, K122P, F171FY, I178M, G196E, R211RK, F214L	B
		2657RT_f1		DDI, AZT, 3TC	None	M41L, L74V, M184V, L210LW		E79EK, K103KR, K122P, I178M, E204A, F214L, K277R, T286A, E297A	B
	ACTG302_2950	2950RT_bl		AZT, DDI	None	L74V, M184V		K11R, R83K, K122E, N147NY, K166R, G196E, A272S, T286A	B
		2950RT_f1		AZT, DDI, 3TC	None	M41L, L74V, M184V		K11KR, R83K, K122E, S162SN, K166R, G196E, A272S, T286A, I293IL, E297K, A299AG	B
	ACTG302_3044	3044RT_bl		AZT, DDI	None	M41L, L74V, T215Y	V179VD	K20R, E28E*, T39TA, E53ED, K122E, I178M, T200TI, Q207E, R211Q, V245M, A272P, L283I, I293V	B
	ACTG302_3329	3329RT_bl		DDI	None	L74V, M184MV		T107TP, Y146YC, Q174H, H198HR, R211RK, F214L, W239WC, K277R, K287KN, I293V	B
	ACTG302_3586	3586RT_bl		DDI	None	L74V, M184V		A98APS, I135T, S162A, R211K, T286A, V292I, E297K	B
	ACTG302_3620	3620RT_bl		AZT, DDI	None	D67N, K70R, L74V, V75T, K219Q		V35I, R83K, K104N, D123E, S162C, I178L, G196E, Q207R, F214FL, A272P, K277R	B
	ACTG302_806	806RT_bl		AZT, DDI	None	L74V		R83K, K122P, I135T, S162A, T165I, D177E, G196E, A272P, K277R, E297K	B
		806RT_f1		AZT, DDI, 3TC	None	A62AV, L74V, M184V		I31IL, E44ED, R83K, K122P, I135T, S162A, T165I, D177E, G196E, F214FL, A272P	B
Ait-Khaled (2002)	MAK-1700	1700481	AJ425986	ABC, AZT, 3TC	None	L74V, M184V		K20R, V35I, K64KR, D86S, K101Q, K103R, I135K, K173E, Q174R, R211K	B
Gibb (2002)	DMG39	39_w44		ABC, 3TC	None	K65KR, L74V, M184V		D123E, S162C, I178IM, R211K, V245VE, A272P, I293V, E297K, L310I, V317VA, M357T, T369A, I375V	B
	DMG49	49_w32		ABC, 3TC	None	L74V, Y115YF, M184V		K122KPQT, D123E, I180IV, Q207E, R211K, A272P, K275R, K277R, Q278H, A288AS, I293IV, E297K, I329L, Q334E, M357T, A360T, A376T, K390R, E396D	B
	DMG63	63_w27		ABC, AZT	None	L74V, M184V		K122KRT, D123E, I180IV, Q207E, R211K, A272P, K275R, K277R, Q278H, R284RK, K287K*, A288AS, I293IV, E297K, I329L, Q334E, M357T, A360T, A376T, K390R, E396D	B
Naugler (2002)	WES-1	HIV1ES	AF422723	AZT, DDI	None	L74V	K103N, Y181C	A33V, V35T, T69N, R83K, D123E	B
	WES-2	HIV2ES	AF422724	AZT, DDI	None	K70R, L74V, T215Y		V35I, D123E, S162C, D177E, R211K	B
	WES-6	HIV6ES	AF422728	AZT, DDI	None	L74V, T215Y		V35I, T39S, R83K, D121Y, K122E, A158S, D177E, G196E	B
	WES-17	HIV17ES	AF422739	AZT, DDI	None	M41L, L74V, L210W, T215Y		T39P, S68G, R83K, D123E, G196S, R211K	B
	WES-22	HIV22ES	AF422744	AZT, DDI	None	K70R, L74V, T215F		T69N, R83K, D177E	B
	WES-23	HIV23ES	AF422745	AZT, DDI	None	M41L, L74V, L210W, T215Y		V35I, R83K, I135T, G196E, R211K	B
Tural (2002)	881309	881309		DDC, AZT, 3TC, DDI	None	L74V, M184V		V8I, V35M, T39A, V60I, R83K, D123E, I135T, T200A, R211K	B
Monno (2003)	ML_pt10	ML131	AY267789	AZT, D4T, 3TC, DDI	None	M41L, L74V, M184V, T215Y		K20KR, K32R, S162C, D177E, R211K	B
Roge (2003)	so7	so7-F1	AY222065	ABC, D4T, DDI	None	M41L, D67N, L74V, L210W, T215Y, K219R		V60I, L120I, E204Q, R211K, D218E	B
		so7-F2	AY222066	ABC, D4T, DDI	None	M41L, D67N, L74V, L210W, T215Y, K219R		V60I, K64N, R72RK, E204Q, R211K, D218E	B
Montes (2004)	MB_patSEGU	00_SEGE704	AJ578157	ABC, 3TC, D4T, DDC, AZT, DDI	None	M41L, D67N, L74V, M184V, L210W, T215Y		K102Q, K122P, I135V, I142V, S162C, I178L, V179I, K238R	B
	MB_patCAS	00_CASE717	AJ577859	DDC, AZT, 3TC, D4T, DDI, ABC	None	M41L, D67N, T69D, L74V, L210W, T215Y	K103N	E6D, T39K, K43E, E44D, V60I, V118I, K122P, D123E, I135T, S162N, K173T, D177E, G196D, E203K, Q207E, H208Y, R211K, K223Q	B
Non-B Workgroup (2005)	BR8	BR8		AZT, DDI, 3TC, D4T	None	M41L, D67N, L74V, L210W, T215Y, K219R		K20R, K32R, T39S, V60I, V90I, V118I, I142V, E169D, H208Y, R211K, K223Q	B
Rhee (2005)	SWC-3692	P3692-978		AZT, 3TC, D4T, DDI	None	L74V, M184V, L210W		R211K	B
	SWC-5577	P5577-906		AZT, D4T, DDC, 3TC	None	M41L, L74V, M184V, L210W, T215Y		K122E, I135V, S162G, E203D, Q207D, R211K	B
	CA4724	CA11972	AY801380	3TC, DDI	None	L74V, M184V		E53D, V60I, D121Y, K122E, R143RS, D177E, I178M, G196E, T200S, I202IL, R211K, K220KI, A272P, K275KN, T286A, I293Y	B
	CA5135	CA38035	AY801491	AZT, 3TC, ABC, DDI	None	L74V, M184V		E6K, K122E, A272S, R284K, I293V	B
	CA6876	CA16949	AY801727	AZT, DDI, D4T, 3TC	None	M41L, D67N, L74V, M184V, L210W, T215Y		K20KR, K22KN, K43Q, V118I, K122E, S134SG, I135IR, I142V, E169D, H208Y, R211K, D218E, Q242QE, K277R, T286A, E297Q, A304G	B
	SWC-1133	1133-4246		3TC, D4T, ABC, DDI	None	L74V, M184V		R83K, K173R, Q174K, Q207E, R211K, I257L	B
	CA16482	CA39152	AY802518	DDI, 3TC	None	L74V, M184V		S68G, A98S, V118VI, G196E, R211K, V245E, A272S, A288ST, I293V, E297KR	B
	CA18383	CA42914	AY802557	D4T, DDI	None	M41L, L74V, L210W, T215Y	K101E	K32N, V35T, K49KR, S68G, V118I, K122E, D123E, I135R, D177E, I178L, E203DN, Q207E, R211K, K223KQ, V245K, E297T	B
Rhee (2009)	CA14413	CA34690	FJ983372	3TC, DDI	None	L74V, M184V		S68SG, R83RK, K102Q, I135M, S162A, E169D, Q207E, A272P, K277R	B

Reverse Transcriptase Inhibitors

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