Reverse Transcriptase Inhibitors

HOME Genotype-Rx Genotype-Pheno Genotype-Clinical hivdb program

Reverse Transcriptase Inhibitors

Subtype	B
Gene	RT
Mutation	L74I
Rx	>= 1 NRTI (but no NNRTI)
IncludeMixtures	No

References	15
Patients	24
Isolates	24

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	NRTIs	NNRTIs	NRTIDRMs	NNRTIDRMs	OtherMut	Subtype
Hammer (1997)	ACTG320_1000	1000		AZT, DDI, D4T	None	M41L, D67N, K70R, L74I, T215FY, K219Q		V35I, E44ED, I50V, D123E, D177E, I178IM, E203D, V245T, A272P, K277R, P294T, E297R, G333E, Q334HY, R356K, G359GS, V365VI, T377S, K390R, T403AV, K431T, L452M, T470S, L486X	B
	ACTG320_1542	1542		AZT, DDC, DDI, D4T	None	M41L, D67N, K70R, L74I, L210W, T215Y, K219Q		K20R, K22R, E44D, V60I, V118I, K122E, G196E, R211A, D218E, K277R, R356K, A360T, A376T, K390R, A400T, K454R, S468P, L469I, L491X	B
Nijhuis (1997)	PT-C0011	C0011W172		3TC, AZT	None	M41L, L74I, M184V, L210W, T215Y		E6D, K43E, R211K, E248D	B
Shafer (1998)	HMDR-4	4	AF047299	AZT, DDC, DDI, D4T, 3TC	None	M41L, D67N, L74I, M184V, L210W, T215Y, K219N	A98G	K43E, E44A, K64R, R83K, V118I, Q161P, S163C, G196E, H208Y, R211K, D218E	B
Deeks (1999)	SD-14	SD-14	AF124549	NRTI, 3TC, DDI	None	M41L, L74I, M184V, L210W, T215Y		D177E, H208Y, R211K, L228R, T286A, T296S, E297EK	B
Balotta (2000)	CB-129	CB-129	AF252000	D4T, 3TC, DDC, AZT, DDI	None	M41L, D67N, L74I, L210W, T215Y, K219R		V35L, T39K, K43E, E44D, T69TI, L80LF, T107TP, V111I, V118I, K122E, S134SR, I135T, I142V, I178L, G196E, E203D, H208Y, R211K, K223Q	B
	CB-183	CB-183	AF252036	DDC, AZT, D4T, 3TC, DDI	None	M41L, L74I, V75T, M184V, L210W, T215Y		K20R, E44D, S68G, R83K, V118I, D123E, S162CY, R211K	B
Baxter (2000)	GART-G108	GART-108		NRTI, 3TC, D4T	None	M41L, D67N, K70R, L74I, M184I, L210W, T215Y, K219Q		K20R, V35L, K122E, A158S, E169D, T200I, R211K, D218E	B
Falloon (2000)	JF08	JF08-12w	AF227720	AZT, DDI, DDC, D4T, 3TC, ABC	None	M41L, D67G, K70R, L74I, M184V, T215F, K219Q		K43Q, K64R, T69N, V118I, F171Y, G196N, T200I, I202V, E204Q, Q207E, R211K, F214L, L228LH, V245T	B
Eshleman (2001)	A083	AF357684	AF357684	AZT, DDI	None	M41L, L74I, L210W, T215F, K219W		V35M, T39TA, K43E, S68G, D123E, I135V, K173E, P176S, G196E, I202IV, H208HY, R211K, V245M, A272P, K277R, E297K, K311R	B
Gonzales (2001)	CA1321	CA3316	AY030521	AZT, 3TC, D4T	None	M41L, D67N, K70R, L74I, M184V, T215Y, K219Q		K20R, V35I, A98S, D123E, I135V, S162D, I178L, H208Y, R211RK, K277R	B
	CA1469	CA3916	AY030604	AZT, 3TC, D4T, DDI	None	M41L, D67N, K70R, L74I, T215F, K219Q		V118I, K122E, I135T, H198HQ, I202V, H208Y, R211K, D218E	B
	CA2103	CA7758	AY030810	AZT, DDI, DDC, D4T, 3TC	None	M41L, A62V, D67N, L74I, M184V, L210W, T215F, K219Q	K103N	V35L, K64KR, K122E, K173E, I178L, V179VI, D218E, L228H	B
Perez (2001)	EP-2154	EP-2154	AF320527	NRTI	None	M41L, D67N, L74I, L210W, T215Y		I63*, K64R, R83K, K104E, V118I, Q174H, I178M, G196E, Q207E, R211K, V245E	B
Papa (2002)	AP_GR50	AP_GR50	AY046882	D4T, 3TC, AZT	None	M41L, L74I, M184V, L210W, T215Y		K43E, V60I, R83K, V118I, S162A, G196E, E203ED, Q207E, R211K	B
Gonzales (2003)	CA3972	CA17451	AF514168	AZT, 3TC, D4T, ABC	None	M41L, D67N, L74I, L210W, T215Y, K219N	K101H	E40F, K43E, V118I, K122E, S162C, E169D, H208Y, R211K, V245M, Q278QH, I293V	B
Dumans (2004)	273	273	AY390121	AZT, DDI, 3TC, D4T	None	M41L, L74I, V75A, M184V, L210W, T215Y		E44D, V118I, K122E, R211A, K223Q	B
Rhee (2005)	CA4060	CA17428	AY801253	AZT, 3TC, ABC	None	M41L, D67N, K70R, L74I, M184V, T215F, K219Q	A98G	V60I, I135V, D177E, G196E, D218E, V245T, D256DV, I293V, I326LV, I329V, A371V, T386I, K390Q, T403R, V435VI, V467VI, L491LS, V531I, A534AS, A554T	B
	CA6418	CA34664	AY801650	AZT, 3TC, D4T, DDI, ABC	None	D67N, K70R, L74I, V75S, M184V, T215V, K219Q		K11KR, K64Y, K122E, N175Y, T200A, I202V, Q207E, L228H, A272P, I293V, S322T, Q334E, M357S, T369TA, K385KR, T386TI, K390R, K395R, A400T, K454R, D460N, R461K, S468T, H483Y, Q509L, K530KR, Q547HN	B
	CA8088	CA20241	AY801950	AZT, 3TC, D4T	None	M41L, L74I, M184V, L210LW, T215Y		S48ST, V118I, D121Y, K122E, K166R, I202IV, H208HY, R211K, V245T, E248DN, A272P, K277R, I293V	B
	CA9898	CA24437	AY802173	AZT, DDI, 3TC	None	M41L, L74I, M184V, L210W, T215Y		A33V, E40F, I178M, G196E, T200A, E203K, Q207K, R211A, K277R, I293V	B
	CA14611	CA35024	AY802389	AZT, 3TC	None	M41L, L74I, M184V, L210W, T215Y, K219N		V35VE, T39A, E40F, K43E, V60I, S68G, V118I, K122E, K166R, G196E, T200I, R211K, A272P, I293V, E302D	B
	CA16262	CA38675	AY802466	AZT, D4T, 3TC, ABC	None	M41L, D67HN, K70R, L74I, M184V, L210W, T215F, K219Q	A98G	V8VI, K20R, T39TAEK, V60I, T69N, K122E, I135T, S162SN, K166R, G196E, H208Y, R211K, D218E, A288S, I293IV	B
von Wyl (2010)	4795747	4795747	GQ848121	AZT, DDI, DDC, D4T, 3TC	None	M41L, D67DN, L74I, M184MI, T215Y, K219R		V35VI, K43Q, E44D, V118I, K122E, D123N, I135T, S162C, Q207E, L210LS, R211K, D218E, V245K, K277R, T286TA, I293V, E297Q, I329V, A360AT, K390R	B

Reverse Transcriptase Inhibitors

Database

Resources

Team