<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype B
Gene RT
Mutation L74I
Rx >= 1 NRTI
(but no NNRTI)
IncludeMixtures No
References 17
Patients 27
Isolates 27
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Hammer (1997)ACTG320_10001000 AZT, DDI, D4TNoneM41L, D67N, K70R, L74I, T215FY, K219Q V35I, E44ED, I50V, D123E, D177E, I178IM, E203D, V245T, A272P, K277R, P294T, E297R, G333E, Q334HY, R356K, G359GS, V365VI, T377S, K390R, T403AV, K431T, L452M, T470S, L486LFB
 ACTG320_15421542 AZT, DDC, DDI, D4TNoneM41L, D67N, K70R, L74I, L210W, T215Y, K219Q K20R, K22R, E44D, V60I, V118I, K122E, G196E, R211A, D218E, K277R, R356K, A360T, A376T, K390R, A400T, K454R, S468P, L469I, L491LFB
Nijhuis (1997)PT-C0011C0011W172 3TC, AZTNoneM41L, L74I, M184V, L210W, T215Y E6D, K43E, R211K, E248DB
Shafer (1998)HMDR-44AF047299AZT, DDC, DDI, D4T, 3TCNoneM41L, D67N, L74I, M184V, L210W, T215Y, K219NA98GK43E, E44A, K64R, R83K, V118I, Q161P, S163C, G196E, H208Y, R211K, D218EB
Deeks (1999)SD-14SD-14AF124549NRTI, 3TC, DDINoneM41L, L74I, M184V, L210W, T215Y D177E, H208Y, R211K, L228R, T286A, T296S, E297EKB
Masquelier (1999)DRO-2DRO2M12AJ239231AZT, DDI, 3TCNoneD67T, K70R, L74I, Q151QLPR, M184V, T215F, K219Q K20R, K22N, Q23QLPR, G45X, T69N, V118I, I135T, R211S, F214LB
Balotta (2000)CB-129CB-129AF252000D4T, 3TC, DDC, AZT, DDINoneM41L, D67N, L74I, L210W, T215Y, K219R V35L, T39K, K43E, E44D, T69TI, L80LF, T107TP, V111I, V118I, K122E, S134SR, I135T, I142V, I178L, G196E, E203D, H208Y, R211K, K223QB
 CB-183CB-183AF252036DDC, AZT, D4T, 3TC, DDINoneM41L, L74I, V75T, M184V, L210W, T215Y K20R, E44D, S68G, R83K, V118I, D123E, S162CY, R211KB
Baxter (2000)GART-G108GART-108 NRTI, 3TC, D4TNoneM41L, D67N, K70R, L74I, M184I, L210W, T215Y, K219Q K20R, V35L, K122E, A158S, E169D, T200I, R211K, D218EB
Falloon (2000)JF08JF08-12wAF227720AZT, DDI, DDC, D4T, 3TC, ABCNoneM41L, D67G, K70R, L74I, M184V, T215F, K219Q K43Q, K64R, T69N, V118I, F171Y, G196N, T200I, I202V, E204Q, Q207E, R211K, F214L, L228LH, V245TB
Eshleman (2001)A083AF357684AF357684AZT, DDINoneM41L, L74I, L210W, T215F, K219W V35M, T39TA, K43E, S68G, D123E, I135V, K173E, P176S, G196E, I202IV, H208HY, R211K, V245M, A272P, K277R, E297K, K311RB
Gonzales (2001)CA1321CA3316AY030521AZT, 3TC, D4TNoneM41L, D67N, K70R, L74I, M184V, T215Y, K219Q K20R, V35I, A98S, D123E, I135V, S162D, I178L, H208Y, R211RK, K277RB
 CA1469CA3916AY030604AZT, 3TC, D4T, DDINoneM41L, D67N, K70R, L74I, T215F, K219Q V118I, K122E, I135T, H198HQ, I202V, H208Y, R211K, D218EB
 CA2103CA7758AY030810AZT, DDI, DDC, D4T, 3TCNoneM41L, A62V, D67N, L74I, M184V, L210W, T215F, K219QK103NV35L, K64KR, K122E, K173E, I178L, V179VI, D218E, L228HB
 CA5321CA13033AY031876D4T, 3TCNoneM41L, D67G, K70R, L74I, M184V, T215F, K219Q K20R, K43KN, K64N, T69N, A129AG, T131TS, I142V, R143RIMS, G196E, I202V, V245K, V261VL, K277R, A288AS, I293VB
Perez (2001)EP-2154EP-2154AF320527NRTINoneM41L, D67N, L74I, L210W, T215Y I63*, K64R, R83K, K104E, V118I, Q174H, I178M, G196E, Q207E, R211K, V245EB
Papa (2002)AP_GR50AP_GR50AY046882D4T, 3TC, AZTNoneM41L, L74I, M184V, L210W, T215Y K43E, V60I, R83K, V118I, S162A, G196E, E203ED, Q207E, R211KB
Gonzales (2003)CA3972CA17451AF514168AZT, 3TC, D4T, ABCNoneM41L, D67N, L74I, L210W, T215Y, K219NK101HE40F, K43E, V118I, K122E, S162C, E169D, H208Y, R211K, V245M, Q278QH, I293VB
Dumans (2004)273273AY390121AZT, DDI, 3TC, D4TNoneM41L, L74I, V75A, M184V, L210W, T215Y E44D, V118I, K122E, R211A, K223QB
Ochoa de Echaguen (2005)B-0717B-0717AY833592AZT, DDI, D4T, 3TC, ABCNoneD67N, K70R, L74I, M184V, K219Q V35I, K64KN, T69N, A158S, I202IV, Q207S, R211K, T215X, K220KT, K281R, A288S, I293V, E297K, K311R, P313XB
Rhee (2005)CA4060CA17428AY801253AZT, 3TC, ABCNoneM41L, D67N, K70R, L74I, M184V, T215F, K219QA98GV60I, I135V, D177E, G196E, D218E, V245T, D256DV, I293V, I326LV, I329V, A371V, T386I, K390Q, T403R, V435VI, V467VI, L491LS, V531I, A534AS, A554TB
 CA6418CA34664AY801650AZT, 3TC, D4T, DDI, ABCNoneD67N, K70R, L74I, V75S, M184V, T215V, K219Q K11KR, K64Y, K122E, N175Y, T200A, I202V, Q207E, L228H, A272P, I293V, S322T, Q334E, M357S, T369TA, K385KR, T386TI, K390R, K395R, A400T, K454R, D460N, R461K, S468T, H483Y, Q509L, K530KR, Q547HNB
 CA8088CA20241AY801950AZT, 3TC, D4TNoneM41L, L74I, M184V, L210LW, T215Y S48ST, V118I, D121Y, K122E, K166R, I202IV, H208HY, R211K, V245T, E248DN, A272P, K277R, I293VB
 CA9898CA24437AY802173AZT, DDI, 3TCNoneM41L, L74I, M184V, L210W, T215Y A33V, E40F, I178M, G196E, T200A, E203K, Q207K, R211A, K277R, I293V, D324N, Q334L, M357T, R358K, V458I, D460N, R461K, V467I, K512R, S519NB
 CA14611CA35024AY802389AZT, 3TCNoneM41L, L74I, M184V, L210W, T215Y, K219N V35VE, T39A, E40F, K43E, V60I, S68G, V118I, K122E, K166R, G196E, T200I, R211K, A272P, I293V, E302DB
 CA16262CA38675AY802466AZT, D4T, 3TC, ABCNoneM41L, D67HN, K70R, L74I, M184V, L210W, T215F, K219QA98GV8VI, K20R, T39TAEK, V60I, T69N, K122E, I135T, S162SN, K166R, G196E, H208Y, R211K, D218E, A288S, I293V, I329V, G333E, R356K, A371V, K390R, E399D, K454R, V466T, V467I, H483Y, E492D, S519N, Q547R, A554TB
von Wyl (2010)47957474795747GQ848121AZT, DDI, DDC, D4T, 3TCNoneM41L, D67DN, L74I, M184MI, T215Y, K219R V35VI, K43Q, E44D, V118I, K122E, D123N, I135T, S162C, Q207E, L210LS, R211K, D218E, V245K, K277R, T286TA, I293V, E297Q, I329V, A360AT, K390R, A400TB