<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype B
Gene RT
Mutation T69S
Rx RTI-naive
IncludeMixtures No
References 68
Patients 205
Isolates 207
Show mutation frequency as:
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Coakley (2000)EC10EC10B NoneNone  K20R, T69S, D177E, R211K, V245K, E248D, D250E, A272P, K277R, T286A, I293V, S468P, S519N, K527NB
Gonzales (2001)CA5409CA13141AY031963NoneNone  T69S, R83RK, K122KE, K154X, K173KN, Q207E, V245EK, A272PB
Perno (2001)PCF_Pat36PCF3276AF376678NoneNone  T69S, R83K, D123E, I135T, D177N, I178M, T200I, V245I, E297AB
de Sa Filho (2002)VT03VT03AF480794NoneNone  T39A, T69S, K122E, I135T, A158S, D177E, I202V, R211KB
Gibb (2002)DMG4141_w0 NoneNone  K49R, T69S, R83K, K281R, I293V, E297K, L301I, K311KR, I326IT, I329IV, G335GC, G359S, A371V, A376T, T377QB
Hanna (2003)HG074HG074AY049580NoneNone  T69S, I142V, G196DE, I202V, V245VMB
Shafer (2003)A384_06150615aEF548293NoneNone  V60I, T69S, K104R, I135L, S162C, T200EQB
 A384_18331833aEF548437NoneNone  T69S, R83K, K122E, S162Y, Q174H, Q197E, I202IV, I244IVB
 A384_10861086aEF548457NoneNone  T69S, D123DE, S162C, D177E, R211KB
 A384_05620562aEF548839NoneNone  T69S, D121H, K122E, I142V, S162C, E169D, D177E, I178M, R211RKB
Gulick (2004)RG141RG141w0 NoneNone  T39L, T69S, K122E, Q207D, R211KB
 RG360RG360w0 NoneNone  T69S, R83K, K122KE, D123DEG, D177EB
Rhee (2005)CA8453CA21221AY802025NoneNone  K20KR, T69S, S162C, D177E, T200A, I202V, V245Q, A272P, K277R, I326V, K366KR, K390R, V435I, R461K, V466I, S468T, T470P, A554TB
 CA9731CA23854AY802089NoneNone  K20R, E28QR, K32E, T69S, V106VI, S162C, R211G, F214L, E224D, D250T, A272AP, K277R, I293VB
 CA9752CA23932AY802100NoneNone  T69S, I135V, K173E, P243S, V245K, V276VI, K277KR, I293VB
 CA16090CA38301AY802424NoneNone  V60I, T69S, I135M, S162Y, V179I, R211RK, V245L, A272P, V292I, I293VB
Jayaraman (2006)1-00-00311-00-0031 NoneNone  T69S, S162C, R211K, S251TB
 1-00-00621-00-0062 NoneNone  T69S, S162C, R211KB
 1-00-00771-00-0077 NoneNone  I47M, T69S, G196K, Q207A, F214LB
 1-00-01161-00-0116 NoneNone  T69S, S162C, R211KB
 2-00-01192-00-0119 NoneNone  T69S, S162C, R211KB
 2-00-01292-00-0129 NoneNoneK70R T69S, S162C, R211KB
 2-01-00202-01-0020 NoneNone  K64R, T69S, S162C, E194G, R211KB
 2-01-00372-01-0037 NoneNone  M16MT, T27P, V35VIM, V60I, T69S, K101R, E138A, I142L, K173N, D177E, I178M, F214LB
Lama (2006)Pt11121112 NoneNone  V35VIM, T39A, V60I, T69S, I132V, K173KE, R211K, D250E, L282LF, T286TA, P294QB
 Pt13641364 NoneNone  K20KR, E36ED, T69S, D86E, D121H, K122E, I135T, K173KEGR, R211RK, A288S, I293V, E297A, V317A, I329VB
 Pt17821782 NoneNone  K13KR, T69S, K102KR, K103KR, S162C, K173R, V245VM, A272P, T286A, V292VI, E297A, K311RB
 Pt30573057 NoneNone V179DK20R, E28A, T69S, K102R, K122E, I135T, D177E, T200A, Q207H, R211K, F214L, V245KN, D250E, A272P, A288S, V292T, I293V, E297A, V317VAB
 Pt35543554 NoneNone V179DEK20KR, E28A, T69S, K122E, I135T, Q207H, R211K, F214L, V245VEKM, D250E, A272P, A288S, V292IT, I293V, E297A, V317AB
 Pt36843684 NoneNone  T69S, D123E, I142IV, K173EQ, T200E, I293IV, E297K, A304E, E312Q, S322SA, I326V, I329VB
 Pt50335033 NoneNone  T69S, K122E, D123S, I135T, T200A, F214L, P294T, P313Q, V317AB
Lindstrom (2006)SIIDC0273SIIDC0273 NoneNone  E6D, T69S, K102Q, I135V, S162C, I178IM, V179VI, T200I, R211T, V245QB
Rodrigues (2006)BR04RS151BR04RS151DQ070638NoneNone  K22N, T39A, T69S, D123E, I135T, I142V, S162C, P226SB
Santos (2006)PA218PA218DQ343990NoneNone  S68G, T69S, K104N, K122E, I178M, T200A, R211K, E248NB
Brumme (2007)1157RT_1157EF369291NoneNone  T69S, I135V, S162C, K173E, R211KB
 1195RT_1195EF369329NoneNone  T69S, S162C, R211K, F227FIB
 1204RT_1204EF369338NoneNone V179DT39TA, V60I, T69S, K122E, I132V, G196E, R211AB
 1440PRRT_1440EF368750NoneNoneD67DA Y56YS, T58TP, A62AP, K64KR, T69S, K104KN, S162C, Q207QH, R211K, A272P, K277R, I293V, E297V, Q334L, A360T, K390R, A400TB
 1486PRRT_1486EF368796NoneNone  T69S, S162C, P176L, R211K, A272P, I293V, E297V, Q334L, A360T, Q367L, A376T, K390R, A400TB
 1575PRRT_1575EF368885NoneNone  T69S, S162C, Q207QE, R211K, F214FL, A272P, K277R, I293V, E297V, K311KR, Q334L, A360T, K390R, Q394QH, E399ED, A400TB
 1647PRRT_1647EF368957NoneNone  T69S, S162C, R211K, A272P, K277KR, I293V, E297V, E298ED, Q334L, A360T, Q367L, K390R, A400TB
 1678PRRT_1678EF368988NoneNone  V35VI, T69S, W71L, K122E, I135L, S162C, T200A, R211K, K277R, L283I, K311KR, D324P, I329L, T386I, K390R, E399D, A400TB
 1679PRRT_1679EF368989NoneNone  E6ED, T69S, S162C, R211K, A272P, K277R, I293V, E297V, Q334L, A360T, T377I, K390R, A400TB
 1725PRRT_1725EF369035NoneNone  T69S, K122E, D123DG, S162C, T200A, R211K, K277R, L283I, E297A, D324P, I329L, K390R, E399D, A400TB
Gatanaga (2007)F04-5103-157-1F04-5103-157-1AB640536NoneNone  S68G, T69S, V106I, K122E, D123A, I135T, D177E, T200IB
Holguin (2007)588427588427EF583200NoneNone  V35M, E44D, T69S, R83K, V118I, T165I, R211K, F214L, E248D, A272P, K277R, T286A, I326V, Q334QLB
 592619592619EF583214NoneNone  V35M, E44D, T69S, R83K, V118I, D123N, T165I, I178M, R211K, F214L, E248D, A272P, V276I, K277R, T286A, I326V, Q334LB
Sanchez Onoro (2007)588427588427 NoneNone  V35M, E44D, T69S, R83K, V118I, T165I, R211K, F214L, E248D, A272P, K277R, T286A, I326V, Q334QLB
 592619592619 NoneNone  V35M, E44D, T69S, R83K, V118I, D123N, T165I, I178M, R211K, F214L, E248D, A272P, V276I, K277R, T286A, I326V, Q334LB
Vicenti (2007)LR_10035868EF376914NoneNone  T69S, I135T, F214LB
 441760621REF376908NoneNone  T69S, T131TS, I135T, F214LB
Chang (2008)TW5980TW5980EU164872NoneNone K103S, G190AE6D, T69S, V179I, Q207R, R211K, F214LB
 TW7708aTW7708a NoneNone  V35I, T69S, R83K, Q207EB
 TW10675aTW10675a NoneNone  V35I, E53ED, T69S, R83RK, I135IV, T165TI, K166KR, T200I, Q207E, R211KB
 TW4863aTW4863a NoneNone V179DV60I, T69S, R83K, K101Q, D123E, I135V, D177E, I178L, I202V, E204K, Q207E, R211KB
 TW7083aTW7083a NoneNone  I5V, V35I, T69S, R83K, I202V, Q207E, R211KB
 TW8552aTW8552a NoneNone  V35I, T69S, K73KE, R83K, D177N, G196E, Q207EB
 TW8670aTW8670a NoneNone V179DV60I, T69S, R83K, D123E, I135V, D177E, I178L, I202V, E204K, Q207E, R211KB
 TW3829aTW3829a NoneNone  V35I, T69S, R83K, K102Q, I135V, S162C, Q207EB
 TW4944aTW4944a NoneNone  E6D, V35I, T69S, R83K, Q207E, V245EB
 TW11617aTW11617a NoneNone V179VDI5V, E6D, V35I, K49KR, T69S, R83K, G99R, T165TR, K173KR, I202V, Q207EB
Ferreira (2008)41BR06PR41EU340728NoneNone  K20R, V60I, T69S, D86E, W88C, A98S, I135T, E138A, K173E, I202V, R211A, F214L, V245EB
Holguin (2008)SP108-321619SP108-321619EU255454NoneNoneK219Q K20R, V35T, V60I, T69S, I135T, N175H, G196E, F214L, A272P, I293V, E297R, A327V, G333E, Q334HB
Ibe (2008)434434AB356404NoneNone  V35T, T69S, D123E, I135IV, S162C, K173KE, T200TA, Q207QK, R211RGB
Miura (2008)BEC35BEC35EU517980NoneNone  T69S, A272P, K277R, Q334Y, A376T, K390R, T403I, V417I, R461RK, H483Q, E514D, V548I, I556V, K558R, V559IB
Brown (2009)CAS_1285_3_913CAS_1285_3_913FJ030667NoneNone Y188YDK20R, T69S, S162C, E203D, R211K, A272AT, K277R, T286AB
Brumme (2009)L3547L3547GQ371986NoneNone  T69S, K102Q, K122E, I135T, I142M, I178M, T200AE, F214L, K281R, T286A, I293V, I326V, M357S, A360T, K385R, K388R, K390R, A400T, V435VA, K454R, D460N, R461K, H483NYB
Cardoso (2009)BRGO3146BRGO3146FJ594178NoneNone  V35T, T69S, K122E, I135M, S162C, K173R, Q174K, Q207EB
Castillo (2009)2525RTGQ202861NoneNone  K20R, T69S, A98S, V118I, I135T, T200A, F214LB
Cuevas (2009)P1420P1420.1EU822648NoneNone  V35L, K49R, T69S, D123E, T139Q, Q145E, S162C, T200A, R211KB
Kousiappa (2009)CY109CY109EU673393NoneNone  T69S, V90VI, D121Y, K122E, I135T, D177E, R211Q, I244V, V245M, A272P, K277R, P294T, Q334EB
Smith (2009)PI109US2003PI109 NoneNone  E53D, T69S, D121H, K122E, I135T, T200A, R211RK, V245K, Y271YS, K277R, I293VB
 PI209US2005PI209 NoneNone  K20R, V35I, T39A, T69S, R83K, I142V, G196E, K281KR, T286P, E297KB
 CR154US2006CR154 NoneNone V179DK20KR, E28A, T69S, A98S, K102KEGR, K103R, L109LIM, I142IT, E169EK, I178M, I180V, T200A, R211T, T286TAB
Vercauteren (2009)pt14104802280712GQ399614NoneNone  I50V, T69S, S162C, G196E, T200A, Q207H, R211Q, V245I, A288S, I293V, V317AB
 pt12635619135181GQ399761NoneNone  K20KR, V35L, V60VI, T69S, R83K, I135V, T200TA, I202V, Q207QR, R211Q, V245VA, A272P, K277R, E297AB
 pt248nfWeKNBCV7GQ400776NoneNone V179DV35T, T69S, V118I, D123N, I142V, K173E, T200I, Q207D, R211K, F214L, V245T, A272PB
 pt221OwAZfzFLifGQ400803NoneNone  E28K, T69S, V118I, I135T, R211K, F214LB
Wang (2009)1229I1229IFJ469685NoneNone  T69S, R83K, K166R, D177E, F214L, V245M, A272P, K281R, I293V, E297K, G333E, G335S, R356K, G359S, A371V, A376V, T386I, A400T, D460N, S519NB
 CR0068PCR0068PFJ469695NoneNone  K20R, T69S, I135T, G196E, F214L, V245I, E248D, K277R, I293V, P294Q, G333E, M357T, A360V, T386V, A400T, D460N, R463K, H483L, K512R, L517V, K527NB
Bonura (2010)1242_1481242_148GU969573NoneNone  V35M, S48E, V60I, T69S, I132IV, I135V, I178IM, E194ED, Q197E, R211K, K277R, T286A, V292I, I293IV, E297A, K311R, V317AB
Brennan (2010)Pat118ARC-A113JN697261NoneNone  E6EK, V35M, T69S, R83K, I178M, T200A, R211G, E248D, A272P, V276VI, K277KR, Q334YB
Descamps (2010)499odyssee499odysseeHQ718332NoneNone  V60I, T69S, R83K, D86E, K122P, D123DE, D177E, Q207E, R211K, V245EB
Hattori (2010)C05-51110293C05-51110293AB864700NoneNone  V35L, T39A, T69S, I135L, S162C, R211K, G231SB
 C06-2069016C06-2069016AB867925NoneNone  V35I, T69S, I135L, E138GB
 F05-5112067F05-5112067AB866620NoneNone  V35I, S68G, T69S, K122E, D123ST, I135T, D177E, G196E, T200I, R211GB
 F05-5112058F05-5112058AB866611NoneNone  S68G, T69S, D123E, I135T, K166R, D177E, I178V, T200IB
 F05-5112072F05-5112072AB866625NoneNone  V35T, T39A, T69S, K104Q, D123E, I135T, S162C, K173Q, Q174R, G196R, Q207E, R211RK, V245NB
 C08-51110766C08-51110766AB865173NoneNone  E6D, K20R, T69S, I135V, Q207E, L210M, R211K, F214LB
 F05-5112056F05-5112056AB866609NoneNone  S68G, T69S, V106VI, K122KE, D123E, I135IT, K166KR, D177E, I178V, T200IB
 E08-50910753E08-50910753AB865941NoneNone  V35I, T69S, V106I, K166I, N175NY, G196E, T200TA, I202IV, F214LB
 F07-5112069F07-5112069AB866705NoneNone  T7P, V35VM, S68G, T69S, D123E, I135T, S162C, D177E, T200A, R211K, D237N, K238SB
Ragonnet-Cronin (2010)PHAC_001PHAC_001HM468499NoneNone  T69S, S162C, T200TI, R211K, A272P, K277KR, I293V, E297IB
 PHAC_007PHAC_007HM468505NoneNone  T69S, S162C, R211K, A272P, K277R, I293V, E297AB
 PHAC_026PHAC_026HM468524NoneNone  T69S, S162C, R211K, A272P, K277R, I293V, E297AB
 PHAC_334PHAC_334HM468832NoneNone  V35M, V60I, T69S, I132IV, D177DN, G196E, Q207K, R211T, T286AB
 PHAC_353PHAC_353HM468851NoneNone  K20R, V21VI, T69S, K102Q, D123E, I135T, S162C, D177E, R211K, A272S, K277R, I293V, E297A, E312QB
 PHAC_370PHAC_370HM468868NoneNone K103NT39A, T69S, I135L, S162C, R211K, A272P, K277R, I293V, E297VB
 PHAC_390PHAC_390HM468888NoneNone  T69S, K122E, I142V, S162C, T200I, R211K, A272P, K277R, I293V, E297VB
 PHAC_391PHAC_391HM468889NoneNone  V60VI, K64R, T69S, I135RT, S162C, T200TI, R211K, W252W*, A272P, K277R, V292VI, I293V, E297AV, E312DB
 PHAC_467PHAC_467HM468965NoneNone K103NT39A, T69S, I135L, S162C, R211K, A272P, K277R, I293V, E297VB
 PHAC_654PHAC_654HM469152NoneNone  T69S, S162C, R211K, A272P, V276I, K277R, I293V, E297VB
 PHAC_789PHAC_789HM469287NoneNone  K20R, T69S, K102Q, D123E, S162C, K173Q, D177E, V179I, R211K, A272P, K277R, I293V, E297AB
Kao (2011)Pat06636552HQ657974NoneNone  I5IV, V35I, T39TA, S68G, T69S, R83K, K101KQ, I135KT, T200I, Q207E, R211K, I293V, E312V, D324E, Q334LB
 Pat04137318HQ657999NoneNone  V8VI, K11KR, V35M, T69S, R83K, T200I, Q207E, F214L, A272P, V276VI, I293V, H315Q, V317A, D324G, Q334LB
 Pat02438871HQ658016NoneNone V179DV21VA, T69S, E79D, R83K, K122E, V245E, A272P, V276I, I293V, E297A, E312Q, S322T, D324E, Q334LB
Rolland (2011)1619consensus_1619JF320120NoneNone  T69S, I135T, S162A, Q207E, V245E, T286A, S322T, I326V, I329V, Q334E, I434L, V435E, V467VI, L491S, A554NSB
Truong (2011)0600337506003375JX073364NoneNone  T69S, I135T, S162C, I178M, R211KB
Zeng (2011)K38K38JF505551NoneNone  T69S, K101R, I135V, S162C, F214LB
 K2K2JF505523NoneNone  K20R, V35T, E36A, T39D, S48T, E53D, V60I, T69S, K122E, I135V, E138A, S162C, Q207E, R211KB
 K23K23JF505525NoneNone  V35T, T39A, S48T, E53D, V60I, K64R, T69S, Q207E, R211KB
 K17K17JF505527NoneNone  K20R, V35T, E36A, T39E, S48T, E53D, V60I, T69S, I135V, S162C, I202V, Q207E, R211KB
 K25K25JF505528NoneNone V179DE28K, K32E, V35T, E36A, T39D, S48E, E53D, V60I, T69S, T107S, I135V, S162C, T200A, Q207E, R211KB
 K33K33JF505582NoneNone  K11R, V35T, E36A, T39D, S48T, E53D, V60I, T69S, D123E, I135L, S162C, Q207E, R211K, I244VB
 K74K74JF505602NoneNone  V35T, E36A, T39D, S48T, K49R, E53D, V60I, T69S, I135T, I142L, Q207N, R211KB
Avila-Rios (2012)C18TME0SSRC18TME0SSRKC168205NoneNone  T69S, D123E, D177E, T200A, I202V, Q207A, R211K, K277R, P294T, E312T, G333EB
 JT00M91OSTJT00M91OSTKC169139NoneNone  T69S, R83K, V90I, K122KQ, D123DE, I135V, E169K, K173E, G196E, T200A, R211K, V245VM, A272S, V276I, L283I, A288T, I293V, Q334EB
 JT00MEFKSUJT00MEFKSUKC169140NoneNone  K20R, T69S, R83K, K102R, D123E, I135IV, Q207E, A272P, I293V, E297A, V317A, I329VB
 M1GTM82LTYM1GTM82LTYKC169252NoneNoneL210LW T69S, R83K, K122P, I135IATV, K173E, D177E, V245M, K277R, Q278E, E297K, L301I, Q334LB
 MT00MG1MUJMT00MG1MUJKC169309NoneNone  K20R, V60I, T69S, I135V, R211RK, V276I, I293V, P294Q, E297A, Q334VB
 CT00MI0PRGCT00MI0PRGKC168230NoneNone  K20R, T69S, K102Q, D123E, S162C, D177DE, I195T, R211RK, I244V, V245M, K275Q, V276I, T286A, A288S, V292I, I293V, P294T, E312N, Q334EB
 OT00FD0NKMOT00FD0NKMKC169492NoneNone  T69S, K102Q, D123N, Y127YNST, S162C, K173EQ, Q207E, A272S, K277R, E312T, S322A, Q334LB
 P000FBAEZRP000FBAEZRKC169497NoneNone  K20R, T69S, A98S, K102R, V179I, G196E, T200A, Q207E, V245VI, I257L, I293V, E297AB
 PCT0X98TJ7PCT0X98TJ7KC169583NoneNone  V60I, T69S, W88C, K102Q, K103KR, K122P, D123DE, I142V, S162H, D177E, V179I, R211RK, T286A, E297K, L301I, Q334LB
 PT00FD3HWMPT00FD3HWMKC169598NoneNone  K20R, T69S, E79D, D86E, K173KR, R211RK, A272P, K311R, D324E, Q334EB
 V1CTMI0KUJV1CTMI0KUJKC169702NoneNone  S48T, E53D, T69S, K102KQ, K103R, Q174E, V179I, Q197P, T200Q, R211K, V276I, L283I, A288S, I293V, E297K, V317A, S322T, D324EB
 VT00M6AETQVT00M6AETQKC169745NoneNone  V35M, T39A, V60I, T69S, R83K, K122E, G152V, V245M, E248EK, V261L, A272P, K277R, I293V, P294S, E297Q, L301I, Q334LB
 B1T0FG0LRXB1T0FG0LRXKC168139NoneNone  T69S, R83K, K102Q, D123E, Q174K, I178L, T200TILS, I202V, A272P, V276I, V292I, I293V, V317A, D324EB
 DT00M_9GT9DT00M_9GT9KC168474NoneNone  V60VI, T69S, R83K, K122P, I135GR, D177E, I178M, G196E, R211K, V245M, A272P, K277R, I293V, S322A, A327S, Q334EB
 DT00M72KZADT00M72KZAKC168475NoneNone  T69S, R83K, K122P, I178L, T200I, R211K, V245M, A272P, K277R, I293V, S322A, Q334EB
 DT00ME2LVBDT00ME2LVBKC168476NoneNone  T69S, R83K, K122P, Q174R, D177E, I178MV, G196E, Q197L, R211K, V245M, A272P, T286TP, I293V, T296S, I326IV, Q334EB
 B8T0F74DT9B8T0F74DT9KC168151NoneNone  T69S, V106I, D121Y, K122E, D177E, T200A, Q207E, A272P, K277KR, E297A, S322T, G333E, Q334GB
 E0T0FC6BT2E0T0FC6BT2KC168644NoneNoneM41L V35M, T69S, I135V, Q197M, T200A, Q207E, A272P, K277R, I293VB
 E1BEF70MTUE1BEF70MTUKC168672NoneNone K103KN, Y188YFHL, P225PHT69S, A98S, E138ED, S162C, I178M, T200A, Q207E, R211K, A272G, V292I, I293V, I326VB
 E1T0M7CCT3E1T0M7CCT3KC168681NoneNone  I50V, V60I, T69S, K122P, I132IV, I142IV, D177E, Q207K, R211E, E248D, A272P, E297K, V317AB
 BTV0MC5TSNBTV0MC5TSNKC168165NoneNone  T69S, E79D, V118I, D123E, I142V, K173KT, D177DE, I178IM, T200TA, Q207E, R211K, F214L, V245VM, E248ED, D250DE, A272P, T286A, I293V, E297V, I326T, Q334YB
 EQT0F87JWXEQT0F87JWXKC168819NoneNoneT215S K64R, T69S, D121H, K122E, S162D, K166R, D177E, I178IM, I202V, Q207E, A272P, K275KR, K277R, I293V, E297K, K311R, I329V, Q334DB
 ET00MABIU0ET00MABIU0KC168822NoneNone  T39A, V60I, T69S, E79Q, K82N, K122P, D177E, Q197E, A272P, P294A, Q334LB
 J2T0M60RSMJ2T0M60RSMKC169060NoneNone  P4S, K20R, T69S, D123E, S162C, K173Q, D177E, Q207E, R211K, A272P, L283I, I293V, E297M, E312T, Q334LB
 J2T0M64OTNJ2T0M64OTNKC169061NoneNone  K20R, V35E, K43KR, T69S, D123E, I135R, S162C, D177E, Q207E, R211K, A272P, I293V, E297V, E312T, Q334LB
 J2T0M68OVOJ2T0M68OVOKC169062NoneNone  T69S, K122E, D123E, I135T, S162C, D177E, Q207E, R211K, A272P, K277R, I293V, E297V, E312T, Q334LB
da Silveira (2012)BRMS02BRMS02JF342274NoneNone  V35T, T69S, K122E, K173D, Q174K, I202V, Q207A, R211K, F214LB
De Gascun (2012)IRL39246IRL39246JN622495NoneNone  S68G, T69S, W88C, I135T, N137ND, T139TA, Y144YC, K154KE, S162H, T200TI, Q207K, R211EB
 IRL17877IRL17877JN622543NoneNone  T69S, W88C, L149LAPV, S162H, Q207K, R211EB
 IRL10835IRL10835JN622626NoneNone  S68G, T69S, W88C, D123E, I135T, S162Y, T200I, Q207N, R211EB
 IRL18091IRL18091JN622639NoneNone  S68G, T69S, W88C, D123E, I135T, S162Y, T200I, Q207N, R211EB
 IRL36682IRL36682JN622673NoneNone  S68G, T69S, W88C, D123E, S162Y, T200I, Q207R, R211EB
 IRL37032IRL37032JN622768NoneNone  S68G, T69S, W88C, D123E, I135T, S162HY, Q207S, R211EB
 IRL70883IRL70883JN622814NoneNone  S68G, T69S, D86E, W88C, I135IT, S162H, Q207K, R211EB
Delwart (2012)476-9708-4476-9708-4JN214903NoneNone  K20R, V35I, T69S, D123E, I135L, K166R, D177E, V179I, R211K, K277R, I293V, P294TB
 480-0341-2480-0341-2JN215205NoneNoneK219Q V35T, E40D, S48T, V60I, T69S, L80R, V118I, K122E, I142T, T200A, I202V, Q207R, F214L, L228K, V245M, D250E, A272P, V292I, E297KB
Frange (2012)751420ERT751420ERTJQ292508NoneNone  K64R, T69S, I135T, I202V, Q207E, F214LB
Karlsson (2012)SE_182SE_182JQ698792NoneNone  T69S, I142IT, K166KR, Q197QH, Q207E, R211RK, F214FL, V245TB
Machado (2012)CUPL1109CUPL1109JX194188NoneNoneK70R V35T, V60I, T69S, K122P, D123E, I135V, S162C, D177E, Q207E, R211K, K238R, V245M, A272P, K277R, T286A, D364E, T369A, A376T, K395RB
Mollan (2012)MK183MK183w0 NoneNone  T69S, K102R, K104T, K122E, I135T, Q174E, R211KB
 MK197MK197w0 NoneNone  T69S, D123E, I142V, S162C, E169D, D177E, R211RKB
 MK87MK87w0 NoneNone  V35VI, T69S, D121Y, K122E, I142V, S162C, T165TI, E169D, D177E, I178IM, E248D, A272P, T286A, E297KB
 MK93MK93w0 NoneNone  K20R, T69S, Q197E, Q207A, R211K, V245VM, I293VB
Ragonnet-Cronin (2012)A05_056A05_056JX014660NoneNone  T69S, S162C, R211K, A272P, K277R, I293V, E297V, K311RB
 A10_043A10_043JX014698NoneNone  T27S, V60I, T69S, R83K, D123S, I135T, N175S, I178L, T200I, R211K, D218E, V245K, T286A, E297XB
 A10_257A10_257JX014783NoneNone V179DK20R, T69S, I135K, G196E, Q197Q*, P243S, A272P, K275R, K277R, K281R, L283I, I293V, E297KB
 A10_303A10_303JX014799NoneNone V179DV35M, E36ED, T39TAS, V60I, T69S, I132V, R211T, T286A, E312AB
 B07_146B07_146JX014912NoneNone  K20R, T69S, K102Q, I135RT, S162C, R211K, A272P, K277R, I293V, E297AB
 C06_022C06_022JX014998NoneNone  T69S, S162C, R211K, A272P, K277R, I293V, E297IB
 C07_047C07_047JX015010NoneNone  K20KR, T69S, S162C, T200TI, R211K, A272P, K277R, I293V, E297A, I309LB
 C07_071C07_071JX015013NoneNone  T69S, V111VM, I142M, S162C, R211S, A272P, K275R, V292I, I293V, E297VB
Ragonnet-Cronin (2012)PHAC07_245PHAC07_245JQ674759NoneNone  T69S, R83K, K101Q, D123E, I135V, V179I, R211K, I257L, T286A, I293V, E297K, K311RB
 PHAC07_267PHAC07_267JQ674771NoneNone  V8VI, K11KR, T69S, A98S, S162C, Q207E, L210LF, V245E, K277R, T286A, I293V, E297KB
 PHAC08_262PHAC08_262JQ674869NoneNone  T69S, S162C, Q207E, K249R, A272P, K277R, I293V, E297AB
 PHAC08_034PHAC08_034JQ675042NoneNone  V35M, T39TA, V60I, T69S, E138A, I142L, K173N, D177E, F214L, A272P, K277R, I293V, E297AB
 PHAC08_261PHAC08_261JQ675162NoneNone  T69S, I142IV, S162C, R211K, A272P, K277R, I293V, E297AVB
 PHAC08_269PHAC08_269JQ675167NoneNone  V35L, T69S, A98S, D121DY, K122KE, S162C, D177DE, I178IL, Q207D, R211K, V245E, K277R, T286A, I293V, E297KB
 PHAC08_273PHAC08_273JQ675171NoneNone  K32KR, T69S, S162C, R211S, V245E, A272P, K277R, I293V, E297AB
Antoniadou (2013)GR097GR097KF671905NoneNone  V60I, T69S, D121H, K122E, I135T, T200I, I202V, R211K, F214FL, V245TB
Chen (2013)11YNHH03311YNHH033JX412339NoneNone  V35T, T39DN, S48T, E53D, V60I, T69S, K122E, D123DN, S162C, E169D, Q174S, I202V, Q207A, R211K, V245Q, A272P, K277R, V292I, I293VB
Frentz (2013)EHR-20760EHR-20760JX299881NoneNone G190GAE6ED, T69S, K122KE, I142T, S162SC, I202IV, R211RS, F214FLB
 EHR-54385EHR-54385JX300446NoneNone  V35L, E36N, I37F, S68G, T69S, W88C, D123E, I135T, S162Y, T200I, Q207N, R211E, I244VB
Hawke (2013)9012642 H9012642 HKC238225NoneNone  V35I, T69S, A98S, A158S, K166KR, T200A, Q207H, R211K, V245MB
Chikata (2014)KI-591KI-591AB873911NoneNone  E6D, K20R, V35M, T69S, I135V, Q207E, R211K, F214L, A272P, S322A, A327V, G335D, R356K, M357T, T403S, V435E, L452A, D460N, R461K, L491S, E492K, Q509H, Q520R, K527R, A554SB
Martin (2014)ACU93ACU93KJ869992NoneNone  V60I, T69S, D121H, K122E, I135T, I142A, T286A, I293V, Q334E, P345Q, M357S, R358K, T377M, K388R, K390R, E399DB
Meixenberger (2014)03-0000503-00005KJ769780NoneNone  K20R, V35L, T69S, R83K, I135T, S162Y, Q207EG, R211RK, V245E, E248D, K277R, L283IB
 09-0172309-01723KJ771010NoneNone  T69S, I142T, S162C, I202V, A272P, K277RB
 12-0129012-01290KJ771727NoneNone  T69S, I135R, I142T, S162C, I202V, E204K, Q207E, A272P, K277RB
 11-0363911-03639KJ771611NoneNone  V35I, K46Q, T69S, K104N, V118I, Q207QR, R211K, F214L, R284K, K287RB
 09-0238309-02383KJ771054NoneNone  T69S, K122E, I135V, G196E, R211K, F214L, R284K, K287RB
 10-0210810-02108KJ771306NoneNone  K32KR, T69S, I135V, E194EK, G196E, R211K, F214L, R284K, K287R, A288ATB
 08-0281208-02812KJ770814NoneNone  E6K, T69S, K104N, V118I, R211K, F214L, R284K, K287RB
 05-0111505-01115KJ770144NoneNone  E6D, T69S, K122A, K173E, I195IV, I202V, Q207E, A272PB
 08-0234508-02345KJ770794NoneNone V179DV35T, V60I, T69S, V118I, D121N, D123N, K173E, D177E, T200I, Q207D, R211K, F214L, V245K, A272P, K277R, T286AB
 10-0215210-02152KJ771318NoneNone  T69S, A98S, K101T, K122A, S162C, V245E, A272P, K277RB
 98-0340098-03400KJ771866NoneNone Y188YDK20R, T69S, S162C, E203D, R211K, A272AT, K277R, T286AB
 12-0003112-00031KJ771666NoneNone  E53ED, T69S, I135V, G196E, R211K, F214L, K277KR, R284K, A288SB
Parczewski (2014)465_BI12465_BI12KM284277NoneNone  V35L, S68G, T69S, K104R, K122KE, I142IM, R211K, A272P, T286AB
 G53_CG53_CKM284573NoneNone  T69S, D123E, I142V, S162C, D177DE, I178IM, T200A, Q207H, R211K, V245I, A272P, K277R, T286TA, I329V, G333EB
Guo (2015)CZU31-2010CZU31-2010KJ724217NoneNone  K20R, V35T, E36A, T39D, S48T, E53D, V60I, T69S, I135V, S162C, Q207E, R211KB
 HUN34-2010HUN34-2010KJ724220NoneNone  K20R, V35T, E36A, T39D, S48T, E53D, V60I, T69S, D123E, I135V, E138A, S162C, E169E*, D177E, E194EQ, Q207EB
Moura (2015)BRMA_266BRMA_266KF782779NoneNone  T69S, I135T, S162C, K173KQ, D177E, I178IM, I202IV, Q207E, R211K, F214LB
Moura (2015)BRPI_17BRPI_17KF700959NoneNone  T69S, K102E, D123N, I178M, Q207E, R211KB
Wang (2015)1109511095KM395797NoneNone  K20R, V35T, E36A, T39N, S48T, E53D, V60I, T69S, I135V, S162C, Q207E, R211K, V245Q, A272P, K277RB
 0614006140KM395783NoneNone  V35T, T39D, S48T, E53D, V60I, T69S, I135V, S162C, Q207E, R211K, V245Q, A272PB
Darcissac (2016)R93ZBJDR93ZBJDKT998041NoneNone  V35T, T69S, A98S, D123E, S162A, D177E, Q207EK, R211EB
Dos Anjos Silva (2016)AP081AP081KT737338NoneNone  V21I, V60I, T69S, D86DN, W88W*, K122E, I135T, G141GR, F171Y, T200A, I202V, R211KB
Panichsillapakit (2016)4kt/200906234kt NoneNone K103N, Y181CE6D, V35M, S68N, T69S, K104KR, K122E, I135L, A158S, E194D, T200A, R211RK, H221YB
 23e/2010031123e NoneNone K103N, Y181CE6D, V35M, T39A, S68T, T69S, K122E, I135L, A158S, V179I, E194D, T200A, R211K, H221YB
 4b3/200505174b3 NoneNone  K20R, V35I, T39A, T69S, R83K, I142V, G196EB
 44r/2003123044r NoneNone  E53D, T69S, D121H, K122E, I135TB
Pessoa (2016)10BR_SP04710BR_SP047KT427804NoneNone K101P, K103SK20KR, V35I, V60I, T69S, D86E, K102Q, I135T, S162H, D177E, V179I, D192N, G196E, V245I, A288S, I293V, E297A, P321S, D324E, L325I, M357V, T386I, K390R, A400T, T403V, V435T, V467I, S468P, H483N, L491S, L517I, K527R, Q547K, K558RB