<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype B
Gene RT
Mutation T69S
Rx >= 1 NRTI
(but no NNRTI)
IncludeMixtures No
References 26
Patients 55
Isolates 68
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Ruiz (1996)JCS-C31C31W24Z99325AZT, DDI, 3TCNoneM41L, D67N, K70R, M184V, T215Y, K219E T69S, K122E, K166R, D177N, T200AB
Hammer (1997)ACTG320_10581058 AZT, DDINoneK70R V35M, T69S, R83K, I135T, A272P, K277R, T286A, E297A, G359S, A371V, A376T, K390R, D460N, V467I, S468P, H483YB
 ACTG320_11031103 AZT, D4TNoneK70R, T215Y K64R, T69S, K103R, Q197E, V245K, S251I, K277R, T286A, Q334E, P345L, A360T, K390R, A400T, T403S, L452LI, D460N, R461K, H483XB
 ACTG320_14231423 AZT, DDINoneK70R, T215Y T69S, R83K, I135T, S162Y, I178IM, R211E, A272P, K277R, E297R, I329L, A400T, E404D, V435VA, A437VB
 ACTG320_25812581 AZT, 3TCNoneK70R V35M, V60VI, T69S, K122KPQT, D123DE, I135V, S162C, D177E, Q207QE, A272P, K277R, A288S, I293V, E297EA, E300EA, I326IVB
Orlandi (1998)PO-Pt20Orl20-W232AF056675AZTNoneM41L, K70R, T215Y K49R, E53D, T69S, A98S, D123EB
  Orl20-W260AF056676AZTNoneM41L, K70R K49R, E53D, T69S, A98S, D123E, T215XB
Pellegrin (1999)IP-43IP43-M10 D4T, DDINone  K32T, V35M, E36EG, T69S, D76X, D123EB
Venturi (1999)GV-4Vent4BAF169048AZTNoneK70R V35T, T69S, D123E, D177N, G196E, F214LB
  Vent4W24AF169049AZT, DDINoneK70R V35T, T69S, D123E, D177N, G196E, F214LB
 GV-5Vent5W24AF169051AZT, DDINoneK70R V35I, V60I, T69S, R83K, D123E, I135TB
Bacheler (2000)LB3-P52P52-0 NRTINone  T69S, A158S, N175H, T200VB
Balotta (2000)CB-316CB-316AF252075AZT, D4T, 3TC, DDINoneD67N, K70KR, M184V, K219Q T69S, R72RK, R83RK, D123E, D177E, I178M, Q207H, R211KB
Baxter (2000)GART-G9GART-9 NRTI, AZT, 3TCNoneM41L, M184V, T215Y K20R, T69S, R83K, D177E, I178M, R211QB
 GART-NG74GART-74 NRTI, 3TC, D4TNoneK70R, M184V S48T, K49KR, T69S, K122E, E169D, I195K, G196E, F214LB
Coakley (2000)EC10EC10F D4T, DDINone  K20R, T69S, D177E, V245K, E248D, D250E, A272P, K277R, T286A, I293V, K347Q, S379G, T403I, E404D, S468P, S519N, K527NB
Albrecht (2001)ACTG364_22512251 AZT, 3TCNoneM41L, M184V, T215Y T69S, D123E, I135T, Q207E, R211K, A272P, T286A, I293VB
 ACTG364_33083308 AZT, DDI, 3TCNoneM41L, A62V, D67E, K70R, F116Y, M184MIV, L210W, T215Y V35I, T39TA, T69S, V90I, V118I, K122KE, S162C, E203EK, R211S, L228H, A272P, K277R, E300X, L301X, A304XB
 ACTG364_33303330 DDI, AZTNoneM41L, T215Y K64KR, T69S, I142T, T165I, Q207E, V245M, D250E, A272P, Q278QH, I293V, E300X, L301X, A304XB
 ACTG364_36043604 AZT, DDCNoneM41L, L210W, T215Y K43E, S48T, T69S, K122KE, S162A, T200TA, E204X, R211RK, V245T, A272PB
 ACTG364_48364836 AZT, 3TCNoneK70R, M184V V21I, T69S, D123E, D177E, A272P, R284X, I293IV, P294HQ, A299AGB
 ACTG364_57105710 AZT, DDI, 3TCNoneA62V, D67E, K70R, T215F V35I, T69S, V118VI, I135T, K173N, G196E, A272P, K277R, Q278H, E297KB
Eshleman (2001)A094AF357695AF357695AZT, DDINoneL74V, M184V V35T, T69S, K104N, I142V, T200A, F214L, D250E, E297KB
Gonzales (2001)CA1286CA3157AY030506AZT, NRTI, 3TCNoneK70R T69S, I135IV, K166R, D177E, R211K, K277R, I293VB
 CA4097CA9389AY031089AZT, DDI, 3TC, D4TNoneM41L, M184V, T215Y K20R, T69S, R83K, T200A, E203D, R211K, T286AB
 CA4443CA10654AY031296AZT, D4T, DDI, 3TCNoneD67N, K70R, M184V T69S, K122E, D123S, I135L, S162C, K166R, K277R, Q278H, T286A, I293V, A304GB
 CA5015CA12286AY031590DDC, D4T, AZT, 3TCNoneA62V, M184V, T215Y K20R, T69S, K122E, I142V, V245R, S251IB
 CA5051CA12331AY031621D4T, 3TCNoneK70R, M184V K20R, T69S, E169D, G196E, Q197K, S251T, K277RB
 CA5258CA12854AY031815D4T, 3TCNoneK70KRV108IT69S, D121C, K122E, K166KR, D177E, I178IL, T200TA, Q207E, R211K, A272PB
 CA5769CA14207AY032159AZT, D4T, 3TCNoneK70R, M184V T69S, A98S, K122E, D123N, I142V, I178L, G196K, Q207H, V245T, K259E, L260V, V261SB
 CA6472CA15990AY032423D4TNoneK70R V35T, T69S, K104R, R211Q, K277R, Q278H, P294TB
Katzenstein (2001)ACTG302_18931893RT_bl AZT, DDINoneD67DE, K70R, F116Y, T215Y V35I, T69S, R83K, S162C, R211RKNS, A272P, K277RB
  1893RT_f1 AZT, DDI, 3TCNoneM41ML, A62V, D67E, K70R, F116Y, M184I, L210W, T215Y V35VI, T69S, R83RK, V90I, V118I, S162C, T165TI, R211S, L228H, A272P, K277R, R284RIB
 ACTG302_35883588RT_bl AZT, DDINoneA62V, K70R, T215F V35I, T69S, R83K, I135T, A158AS, K173N, G196E, A272P, K277R, E297K, E302DB
  3588RT_f1 AZT, DDI, 3TCNoneA62V, D67E, K70R, T215F K20KT, V35I, T69S, I135T, A158AS, K173N, G196E, A272P, K277R, Q278H, E297KB
Perez (2001)EP-2000EP-2000AF320524NRTINoneA62V, L210W, T215Y I63*, K64R, T69S, D121Y, K122E, A158S, S162D, F171L, R172E, K173N, Q174K, I178L, Q207E, R211KB
Shulman (2001)302-150155150155 AZTNoneD67N, K70R, K219Q T69S, V90VI, I135M, S162C, Q174H, G196E, Q207R, V245K, A272P, K281KR, T286AB
 302-211264211264 AZTNoneK70R V35I, T69S, R83K, A158S, R211K, V245M, E248D, T286A, T296S, E297K, A299AG, E302E*B
 302-320288320288 AZTNoneK70R S3SR, V60VI, T69S, R83K, D123E, D177E, I178L, V179I, T200TA, R211KB
Brindeiro (2002)TVGG30TVGG30AY145796AZT, 3TC, D4TNoneM41L, M184V, L210W, T215Y K20R, T39A, E44D, T69S, V118I, K122E, A158L, S162W, D177E, Q207E, V245K, R284K, T286A, I293V, E297AB
Cuevas (2002)CU54CU54AF4254353TCNone  V35T, V60I, T69S, D123E, I135T, I142LB
Papa (2002)AP_GR45AP_GR45AY046878AZT, 3TCNoneM41L, T215E T69S, D123E, F171Y, I178M, R211KB
Tural (2002)140180140180 AZT, DDC, 3TC, D4TNoneM41L, A62V, M184V, T215Y T69S, K122E, I135T, S162X, Q207E, L228HB
Venturi (2002)GV-21GV-21.1AF517273DDC, AZTNoneK70R K20R, T69S, K122E, I135T, K166R, D177X, F214LB
Delgado (2004)090273090273 AZTNoneK70R V35I, T69S, R83K, I135T, K173N, G196GE, T200TA, A272P, K277R, K281KRB
Non-B Workgroup (2005)IL503IL503 AZT, 3TCNoneM184V T69S, A98S, E138A, I142IV, V179I, R211K, K223I, V245EB
Rhee (2005)CA4097CA34364AY801265AZT, DDI, 3TC, D4TNoneM41L, M184V, T215Y K20R, T69S, R83K, K104KR, I135IV, K166KR, T200A, E203D, R211K, T286AB
 CA4565CA37765AY801372AZT, D4T, 3TC, DDINoneD67N, K70R, T215I, K219Q K20KR, S48T, T69S, K122E, I135T, Q197E, F214L, V245KB
 ASRU010ASRU010 D4T, 3TCNoneM184V E6D, T69S, Q207E, R211KB
 CA5015CA34573AY801454DDC, D4T, AZT, 3TCNoneM41L, M184V, T215Y K20R, T69S, K122E, I142V, V245KR, S251I, A272AP, Y339D, A371T, K390R, A400T, V467I, S468T, L469I, K558RB
  CA37877AY801455DDC, D4T, AZT, 3TCNoneM41L, M184V, T215Y K20R, T69S, K122E, I142V, V245KR, S251I, A272PB
 CA5051CA34602AY801468D4T, 3TCNoneK70R, M184V, K219KQ K20R, T69S, E169D, G196E, Q197QK, R211RK, F214FL, S251T, K277R, E297KB
  CA34684AY801469D4T, 3TCNoneK70R, M184V, K219KQ K20R, T69S, E169D, G196E, Q197QK, R211RK, F214FL, S251T, K277R, I293IV, E297KB
 CA5258CA24818AY801528D4T, 3TC, AZTNoneK70R, M184VV108IT69S, D121C, K122E, S162SN, K166R, D177E, I178L, T200A, Q207E, R211RK, A272P, K277R, E297KB
  CA34266AY801529D4T, 3TC, AZTNoneK70R, M184VV108IT69S, D121C, K122E, K166R, D177E, I178IL, T200A, Q207E, R211RK, A272P, K277R, E297KB
  CA48136AY801530D4T, 3TC, AZT, TDFNone V108IT69S, D121C, K122E, K173KQ, D177E, I178L, T200A, Q207E, R211K, A272P, K277R, E297KB
 CA7952CA20027AY801864AZT, 3TC, D4T, DDINoneM41L, L210LW, T215Y T39A, K49E, V60I, T69S, K102KQ, D123DE, I135IT, I142KR, E169D, T200A, R211K, A272AG, T286A, E297KB
 CA8021CA20141AY801905DDC, AZTNoneK70R K66KR, T69S, K122KE, F214L, S251IB
 CA8096CA20255AY801955AZT, 3TC, D4TNoneK70R, M184V T69S, R83K, V90I, I135IV, T139K, S162A, Q207E, R211KB
 CA8453CA34332AY802026AZT, 3TCNoneM184IV T69S, I135IL, S162C, D177E, V245K, A272P, K277R, I326V, F346FC, G359S, K390R, A400T, V435I, R461K, V466I, S468T, T470P, H483Y, A554TB
 CA9752CA34751AY802714D4T, 3TCNoneM184V K30KR, T69S, I135V, K173E, P243S, V245K, K277R, I293V, S322T, A360T, K390R, T403I, K431T, V435A, T470S, I506L, A508G, Q509L, S519N, I556VB
  CA41283AY802715D4T, 3TC, TDFNoneD67N, K70R, K219Q V21VI, T69S, I135V, N137NH, K173E, P243S, V245KB
 CA9881CA34472AY802162AZT, 3TC, D4T, DDINoneD67N, K70R, T215TI, K219Q T39A, K64HN, S68Y, T69S, K103R, K122KE, I135L, F214L, A272P, T286A, V317A, D324E, G333E, Q334H, D364E, D460N, T477A, I482IV, H483Y, S515T, L517I, K527NB
von Wyl (2010)12568081256808GQ848108AZT, DDC, 3TCNoneK70R, M184V T69S, Q174H, Q207R, R211E, F214FL, V245T, I257L, V261I, V317A, S322T, I329L, Q334N, T338S, M357MI, A360V, A376V, T386A, E399EDB
 14796571479657GQ848109AZT, 3TCNoneK70R, M184V, N348I E6D, K64KR, T69S, I135V, K166R, T200I, R211K, F214L, V292I, I293V, D324E, G335S, K353R, R356K, G359GS, K366R, A376TB
Mollan (2012)MK197MK197w89 ABC, 3TCNone  I50IV, T69S, K122KE, D123E, I142IV, S162C, E169D, D177E, I178IM, R211RK, A272P, T286TA, E297KB
 MK93MK93w50 TDF, FTCNone  K20R, T69S, R172RK, Q197E, Q207A, R211K, I293VB
Grossman (2014)20942094KF135021TDF, FTCNone  T39A, E40D, S48T, V60I, S68G, T69S, I178IM, I202V, V245EB