Reverse Transcriptase Inhibitors

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Reverse Transcriptase Inhibitors

Subtype	B
Gene	RT
Mutation	T69S
Rx	>= 1 NRTI (but no NNRTI)
IncludeMixtures	No

References	27
Patients	56
Isolates	69

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	NRTIs	NNRTIs	NRTIDRMs	NNRTIDRMs	OtherMut	Subtype
Ruiz (1996)	JCS-C31	C31W24	Z99325	AZT, DDI, 3TC	None	M41L, D67N, K70R, M184V, T215Y, K219E		T69S, K122E, K166R, D177N, T200A	B
Hammer (1997)	ACTG320_1058	1058		AZT, DDI	None	K70R		V35M, T69S, R83K, I135T, A272P, K277R, T286A, E297A, G359S, A371V, A376T, K390R, D460N, V467I, S468P, H483Y	B
	ACTG320_1103	1103		AZT, D4T	None	K70R, T215Y		K64R, T69S, K103R, Q197E, V245K, S251I, K277R, T286A, Q334E, P345L, A360T, K390R, A400T, T403S, L452LI, D460N, R461K, H483X	B
	ACTG320_1423	1423		AZT, DDI	None	K70R, T215Y		T69S, R83K, I135T, S162Y, I178IM, R211E, A272P, K277R, E297R, I329L, A400T, E404D, V435VA, A437V	B
	ACTG320_2581	2581		AZT, 3TC	None	K70R		V35M, V60VI, T69S, K122KPQT, D123DE, I135V, S162C, D177E, Q207QE, A272P, K277R, A288S, I293V, E297EA, E300EA, I326IV	B
Orlandi (1998)	PO-Pt20	Orl20-W232	AF056675	AZT	None	M41L, K70R, T215Y		K49R, E53D, T69S, A98S, D123E	B
		Orl20-W260	AF056676	AZT	None	M41L, K70R		K49R, E53D, T69S, A98S, D123E, T215X	B
Pellegrin (1999)	IP-43	IP43-M10		D4T, DDI	None			K32T, V35M, E36EG, T69S, D76X, D123E	B
Venturi (1999)	GV-4	Vent4B	AF169048	AZT	None	K70R		V35T, T69S, D123E, D177N, G196E, F214L	B
		Vent4W24	AF169049	AZT, DDI	None	K70R		V35T, T69S, D123E, D177N, G196E, F214L	B
	GV-5	Vent5W24	AF169051	AZT, DDI	None	K70R		V35I, V60I, T69S, R83K, D123E, I135T	B
Bacheler (2000)	LB3-P52	P52-0		NRTI	None			T69S, A158S, N175H, T200V	B
Balotta (2000)	CB-316	CB-316	AF252075	AZT, D4T, 3TC, DDI	None	D67N, K70KR, M184V, K219Q		T69S, R72RK, R83RK, D123E, D177E, I178M, Q207H, R211K	B
Baxter (2000)	GART-G9	GART-9		NRTI, AZT, 3TC	None	M41L, M184V, T215Y		K20R, T69S, R83K, D177E, I178M, R211Q	B
	GART-NG74	GART-74		NRTI, 3TC, D4T	None	K70R, M184V		S48T, K49KR, T69S, K122E, E169D, I195K, G196E, F214L	B
Coakley (2000)	EC10	EC10F		D4T, DDI	None			K20R, T69S, D177E, V245K, E248D, D250E, A272P, K277R, T286A, I293V, K347Q, S379G, T403I, E404D, S468P, S519N, K527N	B
Albrecht (2001)	ACTG364_2251	2251		AZT, 3TC	None	M41L, M184V, T215Y		T69S, D123E, I135T, Q207E, R211K, A272P, T286A, I293V	B
	ACTG364_3308	3308		AZT, DDI, 3TC	None	M41L, A62V, D67E, K70R, F116Y, M184MIV, L210W, T215Y		V35I, T39TA, T69S, V90I, V118I, K122KE, S162C, E203EK, R211S, L228H, A272P, K277R, E300X, L301X, A304X	B
	ACTG364_3330	3330		DDI, AZT	None	M41L, T215Y		K64KR, T69S, I142T, T165I, Q207E, V245M, D250E, A272P, Q278QH, I293V, E300X, L301X, A304X	B
	ACTG364_3604	3604		AZT, DDC	None	M41L, L210W, T215Y		K43E, S48T, T69S, K122KE, S162A, T200TA, E204X, R211RK, V245T, A272P	B
	ACTG364_4836	4836		AZT, 3TC	None	K70R, M184V		V21I, T69S, D123E, D177E, A272P, R284X, I293IV, P294HQ, A299AG	B
	ACTG364_5710	5710		AZT, DDI, 3TC	None	A62V, D67E, K70R, T215F		V35I, T69S, V118VI, I135T, K173N, G196E, A272P, K277R, Q278H, E297K	B
Eshleman (2001)	A094	AF357695	AF357695	AZT, DDI	None	L74V, M184V		V35T, T69S, K104N, I142V, T200A, F214L, D250E, E297K	B
Gonzales (2001)	CA1286	CA3157	AY030506	AZT, NRTI, 3TC	None	K70R		T69S, I135IV, K166R, D177E, R211K, K277R, I293V	B
	CA4097	CA9389	AY031089	AZT, DDI, 3TC, D4T	None	M41L, M184V, T215Y		K20R, T69S, R83K, T200A, E203D, R211K, T286A	B
	CA4443	CA10654	AY031296	AZT, D4T, DDI, 3TC	None	D67N, K70R, M184V		T69S, K122E, D123S, I135L, S162C, K166R, K277R, Q278H, T286A, I293V, A304G	B
	CA5015	CA12286	AY031590	DDC, D4T, AZT, 3TC	None	A62V, M184V, T215Y		K20R, T69S, K122E, I142V, V245R, S251I	B
	CA5051	CA12331	AY031621	D4T, 3TC	None	K70R, M184V		K20R, T69S, E169D, G196E, Q197K, S251T, K277R	B
	CA5258	CA12854	AY031815	D4T, 3TC	None	K70KR	V108I	T69S, D121C, K122E, K166KR, D177E, I178IL, T200TA, Q207E, R211K, A272P	B
	CA5769	CA14207	AY032159	AZT, D4T, 3TC	None	K70R, M184V		T69S, A98S, K122E, D123N, I142V, I178L, G196K, Q207H, V245T, K259E, L260V, V261S	B
	CA6472	CA15990	AY032423	D4T	None	K70R		V35T, T69S, K104R, R211Q, K277R, Q278H, P294T	B
Katzenstein (2001)	ACTG302_1893	1893RT_bl		AZT, DDI	None	D67DE, K70R, F116Y, T215Y		V35I, T69S, R83K, S162C, R211RKNS, A272P, K277R	B
		1893RT_f1		AZT, DDI, 3TC	None	M41ML, A62V, D67E, K70R, F116Y, M184I, L210W, T215Y		V35VI, T69S, R83RK, V90I, V118I, S162C, T165TI, R211S, L228H, A272P, K277R, R284RI	B
	ACTG302_3588	3588RT_bl		AZT, DDI	None	A62V, K70R, T215F		V35I, T69S, R83K, I135T, A158AS, K173N, G196E, A272P, K277R, E297K, E302D	B
		3588RT_f1		AZT, DDI, 3TC	None	A62V, D67E, K70R, T215F		K20KT, V35I, T69S, I135T, A158AS, K173N, G196E, A272P, K277R, Q278H, E297K	B
Perez (2001)	EP-2000	EP-2000	AF320524	NRTI	None	A62V, L210W, T215Y		I63*, K64R, T69S, D121Y, K122E, A158S, S162D, F171L, R172E, K173N, Q174K, I178L, Q207E, R211K	B
Shulman (2001)	302-150155	150155		AZT	None	D67N, K70R, K219Q		T69S, V90VI, I135M, S162C, Q174H, G196E, Q207R, V245K, A272P, K281KR, T286A	B
	302-211264	211264		AZT	None	K70R		V35I, T69S, R83K, A158S, R211K, V245M, E248D, T286A, T296S, E297K, A299AG, E302E*	B
	302-320288	320288		AZT	None	K70R		S3SR, V60VI, T69S, R83K, D123E, D177E, I178L, V179I, T200TA, R211K	B
Brindeiro (2002)	TVGG30	TVGG30	AY145796	AZT, 3TC, D4T	None	M41L, M184V, L210W, T215Y		K20R, T39A, E44D, T69S, V118I, K122E, A158L, S162W, D177E, Q207E, V245K, R284K, T286A, I293V, E297A	B
Cuevas (2002)	CU54	CU54	AF425435	3TC	None			V35T, V60I, T69S, D123E, I135T, I142L	B
Papa (2002)	AP_GR45	AP_GR45	AY046878	AZT, 3TC	None	M41L, T215E		T69S, D123E, F171Y, I178M, R211K	B
Tural (2002)	140180	140180		AZT, DDC, 3TC, D4T	None	M41L, A62V, M184V, T215Y		T69S, K122E, I135T, S162X, Q207E, L228H	B
Venturi (2002)	GV-21	GV-21.1	AF517273	DDC, AZT	None	K70R		K20R, T69S, K122E, I135T, K166R, D177X, F214L	B
Delgado (2004)	090273	090273		AZT	None	K70R		V35I, T69S, R83K, I135T, K173N, G196GE, T200TA, A272P, K277R, K281KR	B
Non-B Workgroup (2005)	IL503	IL503		AZT, 3TC	None	M184V		T69S, A98S, E138A, I142IV, V179I, R211K, K223I, V245E	B
Rhee (2005)	CA4097	CA34364	AY801265	AZT, DDI, 3TC, D4T	None	M41L, M184V, T215Y		K20R, T69S, R83K, K104KR, I135IV, K166KR, T200A, E203D, R211K, T286A	B
	CA4565	CA37765	AY801372	AZT, D4T, 3TC, DDI	None	D67N, K70R, T215I, K219Q		K20KR, S48T, T69S, K122E, I135T, Q197E, F214L, V245K	B
	ASRU010	ASRU010		D4T, 3TC	None	M184V		E6D, T69S, Q207E, R211K	B
	CA5015	CA34573	AY801454	DDC, D4T, AZT, 3TC	None	M41L, M184V, T215Y		K20R, T69S, K122E, I142V, V245KR, S251I, A272AP, Y339D, A371T, K390R, A400T, V467I, S468T, L469I, K558R	B
		CA37877	AY801455	DDC, D4T, AZT, 3TC	None	M41L, M184V, T215Y		K20R, T69S, K122E, I142V, V245KR, S251I, A272P	B
	CA5051	CA34602	AY801468	D4T, 3TC	None	K70R, M184V, K219KQ		K20R, T69S, E169D, G196E, Q197QK, R211RK, F214FL, S251T, K277R, E297K	B
		CA34684	AY801469	D4T, 3TC	None	K70R, M184V, K219KQ		K20R, T69S, E169D, G196E, Q197QK, R211RK, F214FL, S251T, K277R, I293IV, E297K	B
	CA5258	CA24818	AY801528	D4T, 3TC, AZT	None	K70R, M184V	V108I	T69S, D121C, K122E, S162SN, K166R, D177E, I178L, T200A, Q207E, R211RK, A272P, K277R, E297K	B
		CA34266	AY801529	D4T, 3TC, AZT	None	K70R, M184V	V108I	T69S, D121C, K122E, K166R, D177E, I178IL, T200A, Q207E, R211RK, A272P, K277R, E297K	B
		CA48136	AY801530	D4T, 3TC, AZT, TDF	None		V108I	T69S, D121C, K122E, K173KQ, D177E, I178L, T200A, Q207E, R211K, A272P, K277R, E297K	B
	CA7952	CA20027	AY801864	AZT, 3TC, D4T, DDI	None	M41L, L210LW, T215Y		T39A, K49E, V60I, T69S, K102KQ, D123DE, I135IT, I142KR, E169D, T200A, R211K, A272AG, T286A, E297K	B
	CA8021	CA20141	AY801905	DDC, AZT	None	K70R		K66KR, T69S, K122KE, F214L, S251I	B
	CA8096	CA20255	AY801955	AZT, 3TC, D4T	None	K70R, M184V		T69S, R83K, V90I, I135IV, T139K, S162A, Q207E, R211K	B
	CA8453	CA34332	AY802026	AZT, 3TC	None	M184IV		T69S, I135IL, S162C, D177E, V245K, A272P, K277R, I326V, F346FC, G359S, K390R, A400T, V435I, R461K, V466I, S468T, T470P, H483Y, A554T	B
	CA9752	CA34751	AY802714	D4T, 3TC	None	M184V		K30KR, T69S, I135V, K173E, P243S, V245K, K277R, I293V, S322T, A360T, K390R, T403I, K431T, V435A, T470S, I506L, A508G, Q509L, S519N, I556V	B
		CA41283	AY802715	D4T, 3TC, TDF	None	D67N, K70R, K219Q		V21VI, T69S, I135V, N137NH, K173E, P243S, V245K	B
	CA9881	CA34472	AY802162	AZT, 3TC, D4T, DDI	None	D67N, K70R, T215TI, K219Q		T39A, K64HN, S68Y, T69S, K103R, K122KE, I135L, F214L, A272P, T286A, V317A, D324E, G333E, Q334H, D364E, D460N, T477A, I482IV, H483Y, S515T, L517I, K527N	B
Weber (2005)	01M6122	01M6122	AY677602	AZT, 3TC	None	K70R, M184V		E6D, V35T, V60I, T69S, D121Y, K122E, K173A, Q174K, D177E, V179I, Q207A, R211S, F214L, V245T, P247T, D250E, A272P, K277R, L282C, T286A, I293V, E297A	B
von Wyl (2010)	1256808	1256808	GQ848108	AZT, DDC, 3TC	None	K70R, M184V		T69S, Q174H, Q207R, R211E, F214FL, V245T, I257L, V261I, V317A, S322T, I329L, Q334N, T338S, M357MI, A360V, A376V, T386A, E399ED	B
	1479657	1479657	GQ848109	AZT, 3TC	None	K70R, M184V, N348I		E6D, K64KR, T69S, I135V, K166R, T200I, R211K, F214L, V292I, I293V, D324E, G335S, K353R, R356K, G359GS, K366R, A376T	B
Mollan (2012)	MK197	MK197w89		ABC, 3TC	None			I50IV, T69S, K122KE, D123E, I142IV, S162C, E169D, D177E, I178IM, R211RK, A272P, T286TA, E297K	B
	MK93	MK93w50		TDF, FTC	None			K20R, T69S, R172RK, Q197E, Q207A, R211K, I293V	B
Grossman (2014)	2094	2094	KF135021	TDF, FTC	None			T39A, E40D, S48T, V60I, S68G, T69S, I178IM, I202V, V245E	B

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