<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype B
Gene RT
Mutation D67G
Rx >= 1 NRTI
(but no NNRTI)
IncludeMixtures No
References 24
Patients 39
Isolates 53
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Ruiz (1996)JCS-C47C47BZ99336AZT, DDINoneD67G, K70R, K219Q I5N, T69N, R83K, V118I, F214L, V245KB
Hammer (1997)ACTG320_25162516 AZT, DDI, D4TNoneD67G, K70R, K219Q V35M, S68G, D177DE, I178M, G196GE, I202IV, Q207H, R211K, A272P, K277R, T286TA, E297K, E312EA, V317A, D324P, I329V, G333E, G335S, V365I, A376S, T386I, D460N, L469FB
 ACTG320_617617 AZT, DDINoneM41L, D67G, T69D, K70R, V75M, L210W, T215Y, K219Q K20R, E44ED, V60I, R83K, S162Y, I178M, R211RK, D218DE, K277R, I293V, A360T, K390R, K395R, E399D, A400T, K451R, S468PB
Winters (1997)KA0011625KA001162528862 AZT, 3TC, D4TNoneD67G, M184V I31L, D121DY, S162C, E169D, G196E, Q207E, R211K, A272EG, V276I, A288G, I293V, P313E, V317A, D324E, F346Y, A355G, M357A, A360T, T377M, S468P, T470M, K527N, V559IB
Winters (1998)MW-ins12jci-12AF096892AZT, DDINoneM41L, D67G, T69S_EA, L210W, T215Y K122P, I135T, I178M, R211K, A272P, E300G, L301A, E302R, L303T, A304GB
Deeks (1999)SD-6SD-6AF124544NRTI, D4T, 3TCNoneD67G, K70R, M184V, K219Q K20R, S68G, K122E, Q207AE, R211K, T286AB
Zolopa (1999)CA626CA3200AF088111AZT, DDI, D4T, 3TCNoneD67G, K70G, F77L, F116Y, Q151M, M184V I31X, S68N, Q207E, F214L, T286AB
Albrecht (2000)ACTG303_481481RT_f1 AZT, DDI, 3TCNoneD67G, K70R, M184V, T215F, K219Q K20R, V35I, K43Q, K64N, K102Q, I135L, S162H, T200A, D218E, L228LH, V245KB
Bacheler (2000)LB4-P105P105-0 AZT, 3TCNoneM41L, D67G, K70R, M184V, K219Q K20R, V60I, T69N, K104N, I135T, I202V, R211GB
Baxter (2000)GART-NG11GART-11 NRTI, D4T, DDINoneM41L, D67G, L210W, T215Y K20R, T39K, K43E, E44D, V60I, V118I, I142V, G196E, T200E, E203K, H208Y, R211K, K223E, L228R, V245E, E248DB
 GART-NG45GART-45 NRTI, AZT, 3TCNoneD67G, K70R, M184V, T215F, K219EV179EK20R, S68G, K122R, D123E, I135T, D177E, Q207E, R211KB
Falloon (2000)JF08JF08-(-)6wAF227719AZT, DDI, DDC, D4T, 3TCNoneD67G, K70R, M184V, T215F, K219Q K43KQ, K64R, T69N, V118I, I135M, G196N, T200I, I202V, E204Q, Q207E, R211K, F214L, V245TB
  JF08-12wAF227720AZT, DDI, DDC, D4T, 3TC, ABCNoneM41L, D67G, K70R, L74I, M184V, T215F, K219Q K43Q, K64R, T69N, V118I, F171Y, G196N, T200I, I202V, E204Q, Q207E, R211K, F214L, L228LH, V245TB
 JF09JF09-0wAF227721AZT, DDI, DDC, D4T, 3TCNoneD67G, T69D, K70R, M184V, T215F, K219Q S68G, V118I, I135T, Q197QK, F214L, D218DEB
  JF09-9wAF227722AZT, DDI, DDC, D4T, 3TC, ABCNoneD67G, T69D, K70R, M184V, T215F, K219Q S68G, V118I, I135T, Q197K, F214L, D218EB
Parkin (2000)SD-6SD-6_5AF294522NRTI, D4T, 3TC, ABCNoneD67G, K70R, M184V, T215TA, K219Q K20R, S68G, K122E, I135IT, I202IV, Q207AE, R211KQ, T286AB
  SD-6_9AF294523NRTI, D4T, 3TC, ABCNoneD67G, K70R, M184V, K219Q K20R, S68G, K122E, I202IV, E203ED, Q207AE, R211KQ, F214FL, T215X, T286AB
  SD-6_18AF294524NRTI, D4T, 3TC, ABCNoneD67G, K70R, M184V, K219Q K20R, S68G, K122E, I135IT, I202IV, Q207AE, R211KQ, T215X, T286AB
Albrecht (2001)ACTG364_12421242 AZT, DDC, 3TCNoneD67G, K70R, M184V, T215Y, K219E V35T, S68G, K166KR, Q207E, A272P, V276X, Q278AB
 ACTG364_28772877 AZT, 3TCNoneD67G, K70R, M184V, T215FV, K219Q K20R, S68SG, R211S, D218DE, E224ED, K281R, I293V, E297KB
 ACTG364_3535 AZT, DDC, DDI, 3TCNoneD67G, K70R, M184V, K219Q V35M, K64H, T69N, V118I, F214L, D218E, V245TB
 ACTG364_777777 AZT, DDI, 3TCNoneM41ML, D67G, T69D, K70R, M184V, T215FV, K219Q K20KR, S48T, K64H, V118I, I135T, E138EQ, F214L, D218DE, L228H, K259K*, A272AS, Q278H, A288T, T290TSB
 ACTG364_88 AZT, DDI, 3TCNoneD67G, K70R, M184V, T215F, K219Q K20R, V35IM, K43Q, K64N, K102Q, K104KN, I135L, S162H, T200A, Q207QH, D218E, L228LH, V245K, A272P, T286AB
Gonzales (2001)CA1447CA3863AY030585AZT, 3TC, D4TNoneM41L, D67G, L210W, T215Y A98S, K102Q, K122E, A272P, I293VB
 CA2196CA7968AY030820AZT, DDI, 3TCNoneD67G, K70R, M184V, T215F, K219Q S68G, I142V, Q207E, D218E, V245K, I293VB
 CA3914CA9117AY030917AZT, 3TC, DDC, D4T, DDINoneD67G, T69D, K70R K64R, I132IM, N137X, I142V, G196E, R211A, F214L, V245MB
 CA4743CA11613AY0314053TC, D4TNoneM41L, D67G, T69D, K70R, M184V, T215F K20R, S68G, I135T, S162CY, I178M, Q207E, Q258Q*, N265NI, A272P, A288S, E297KB
 CA5321CA13033AY031876D4T, 3TCNoneM41L, D67G, K70R, L74I, M184V, T215F, K219Q K20R, K43KN, K64N, T69N, A129AG, T131TS, I142V, R143X, G196E, I202V, V245K, V261VL, K277R, A288AS, I293VB
 CA6805CA16855AY032538D4T, DDINoneD67G V35L, R83K, D123E, I135V, D177E, I195M, R211K, I293VB
Masquelier (2002)apv13apv13M4AY134468AZT, 3TCNoneA62V, D67G, M184V R83K, I135T, S162C, Q174H, D177E, G196E, Q197KB
Gonzales (2003)CA626CA1193AF513998AZT, DDI, D4T, 3TCNoneD67G, K70G, F77L, F116Y, Q151M, M184V S68N, Q207E, F214L, T286AB
 CA6805CA21219AF514245D4T, DDINoneD67G V35L, R83K, D123E, I135V, D177E, I195IM, R211K, I293VB
Shafer (2003)A384_31913191bEF548372AZT, 3TCNoneD67G, K219Q E6EK, K11KR, V35T, K64N, T200TI, D218EB
Kuritzkes (2004)KDR_pat268DRK_A0371AY528188AZT, 3TCNoneD67G, M184V T39TA, V60VI, S68G, D121H, K122E, I135T, K166R, D177E, G196EB
Machado (2004)cs151cs151AY313421AZT, DDINoneM41L, D67G, T69S_SG, T215Y A158S, D177E, T200A, R211TB
Garcia-Bujalance (2005)GBS_26GBS_26AY872361D4T, 3TCNoneD67G, K70R, M184V, K219E S68G, T69N, T84P, D113H, D123DE, I135T, S162C, Q174QR, G196E, R211KB
Rhee (2005)CA4743CA24343AY8013863TC, D4TNoneM41L, D67G, T69D, K70R, M184V, T215F T7TA, K20R, T39TA, S68G, I135T, S162Y, Q174QH, I178M, Q207E, L228LHQ, A272P, A288S, E297KB
  CA24345AY8027043TC, D4TNoneM41L, D67G, T69D, K70R, M184V, T215F T7TA, K20KR, T39TA, S68G, I135T, S162Y, Q174QH, I178M, Q207E, L228X, A272P, A288S, E297KB
  CA34921AY8013873TC, D4TNoneM41L, D67G, T69D, K70R, M184V, T215F T7TA, K20KR, T39TA, S68G, I135T, S162Y, Q174H, I178IM, Q207E, L228LHQ, A272P, A288S, E297K, G333E, R356K, A360T, A376S, T386I, K390R, A400T, N418S, K431N, V435A, L469I, T470P, H483Y, L491S, I506L, S519N, E529D, K530R, V531I, I556VB
  CA42712AY8013883TC, D4TNoneM41L, D67G, T69D, K70R, M184MV, T215F T7TA, T39TA, S68G, I135T, S162Y, Q174H, Q207E, L228Q, V245VMB
 CA4782CA20180AY801400AZT, D4T, 3TC, ABCNoneD67G, K70R, M184V, T215F, K219Q K20R, S68G, I135V, F214L, D218DEB
  CA34721AY801401AZT, D4T, 3TC, ABCNoneD67G, K70R, M184V, T215F, K219Q K20R, S68G, I135V, F214L, D218E, A272P, T286A, A288S, I293V, E297AB
 CA7848CA19878AY801794AZT, DDI, D4T, 3TC, ABCNoneM41L, D67G, T69D, V75VL, M184I, L210W, T215Y, K219R K43KN, E44D, V60I, V118I, K122E, D123E, I135T, I142V, G196E, I202X, E203EK, Q207E, H208Y, R211K, H221HY, K223KE, V245K, A272PB
  CA23659AY801795AZT, DDI, D4T, 3TC, ABCNoneM41L, D67G, T69D, M184I, L210W, T215Y, K219RF227FLT39TP, K43KN, E44D, S48SP, V60I, V118I, K122E, D123E, I135T, I142V, G196E, E203K, Q207E, H208Y, R211K, K223E, V245K, A272P, M357T, I375V, K390R, A400T, V435I, V458I, L469I, S519N, K527Q, A554S, K558RB
 CA8037CA20166AY801921AZT, DDC, D4T, 3TCNoneD67G, K70R, M184V, K219Q K64H, T69N, T200A, R211K, F214L, D218E, K277RB
  CA48180AY801922AZT, DDC, D4T, 3TCNoneD67G, K70R, M184V, K219Q K64H, T69N, V118I, Q174QR, V179VI, T200A, R211K, F214L, D218E, K277R, I293V, T296TS, E297RB
 SWC-85468546-3393 AZT, DDC, 3TC, D4TNoneD67G, T215V, K219Q V35I, K64H, T69N, A98S, V118I, V179T, T200E, R211K, F214L, S251NB
 CA16089CA38299AY802423AZT, 3TCNoneD67G, K70KR, M184V I31L, I94IL, R211K, V245K, S251I, I326V, K366R, T403M, R463K, V467I, H483Y, L491S, E516D, S519N, I556V, K558RB
 CA17694CA41631AY802545D4T, 3TCNoneM41L, A62V, D67G, M184V, L210W, T215Y, K219RV108IK20R, K43Q, E44D, K102S, V106I, T107A, V118I, K122E, Q174E, G196E, H208Y, R211K, K223Q, L228H, E297K, K350EB
Rhee (2006)CA8369CA21096DQ316615DDI, DDC, AZT, 3TCNoneD67G, T69D, K70R, M184V, K219Q K20R, A33G, V118I, K122E, I135T, Q197P, T200A, F214L, T286P, I293V, E297AB
Rosen-Zvi (2008)2500p25-1 AZT, DDI, DDC, 3TC, D4TNoneM41L, D67G, T69D, T215Y K20R, V60I, S68G, R83K, D123E, I135V, R211K, V245E, A272P, E297KB
Dumans (2009)RENA686RENA686FJ405043AZT, 3TCNoneD67G, K70R, M184V, T215F, K219EK103NK20R, V35M, S68G, R83K, D123E, V245K, A272P, K281R, E297R, Q334DB
Rhee (2009)CA14225CA34363FJ983352AZT, DDC, 3TC, D4TNoneM41L, D67G, T69D, L210W, T215Y, K219R, N348I E6D, V60VI, V118I, K122E, D123E, I135V, I142V, S162C, R211K, V245K, I293V, M357T, T369A, A400I, K451R, S468P, L469I, T470EKB