Reverse Transcriptase Inhibitors

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Reverse Transcriptase Inhibitors

Subtype	B
Gene	RT
Mutation	D67G
Rx	>= 1 NRTI (but no NNRTI)
IncludeMixtures	No

References	24
Patients	38
Isolates	52

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	NRTIs	NNRTIs	NRTIDRMs	NNRTIDRMs	OtherMut	Subtype
Ruiz (1996)	JCS-C47	C47B	Z99336	AZT, DDI	None	D67G, K70R, K219Q		I5N, T69N, R83K, V118I, F214L, V245K	B
Hammer (1997)	ACTG320_2516	2516		AZT, DDI, D4T	None	D67G, K70R, K219Q		V35M, S68G, D177DE, I178M, G196GE, I202IV, Q207H, R211K, A272P, K277R, T286TA, E297K, E312EA, V317A, D324P, I329V, G333E, G335S, V365I, A376S, T386I, D460N, L469F	B
	ACTG320_617	617		AZT, DDI	None	M41L, D67G, T69D, K70R, V75M, L210W, T215Y, K219Q		K20R, E44ED, V60I, R83K, S162Y, I178M, R211RK, D218DE, K277R, I293V, A360T, K390R, K395R, E399D, A400T, K451R, S468P	B
Winters (1997)	KA0011625	1162528862		AZT, 3TC, D4T	None	D67G, M184V		I31L, D121DY, S162C, E169D, G196E, Q207E, R211K, A272EG, V276I, A288G, I293V	B
Winters (1998)	MW-ins12	jci-12	AF096892	AZT, DDI	None	M41L, D67G, T69S_EA, L210W, T215Y		K122P, I135T, I178M, R211K, A272P, E300G, L301A, E302R, L303T, A304G	B
Deeks (1999)	SD-6	SD-6	AF124544	NRTI, D4T, 3TC	None	D67G, K70R, M184V, K219Q		K20R, S68G, K122E, Q207AE, R211K, T286A	B
Zolopa (1999)	CA626	CA3200	AF088111	AZT, DDI, D4T, 3TC	None	D67G, K70G, F77L, F116Y, Q151M, M184V		I31X, S68N, Q207E, F214L, T286A	B
Albrecht (2000)	ACTG303_481	481RT_f1		AZT, DDI, 3TC	None	D67G, K70R, M184V, T215F, K219Q		K20R, V35I, K43Q, K64N, K102Q, I135L, S162H, T200A, D218E, L228LH, V245K	B
Bacheler (2000)	LB4-P105	P105-0		AZT, 3TC	None	M41L, D67G, K70R, M184V, K219Q		K20R, V60I, T69N, K104N, I135T, I202V, R211G	B
Baxter (2000)	GART-NG11	GART-11		NRTI, D4T, DDI	None	M41L, D67G, L210W, T215Y		K20R, T39K, K43E, E44D, V60I, V118I, I142V, G196E, T200E, E203K, H208Y, R211K, K223E, L228R, V245E, E248D	B
	GART-NG45	GART-45		NRTI, AZT, 3TC	None	D67G, K70R, M184V, T215F, K219E	V179E	K20R, S68G, K122R, D123E, I135T, D177E, Q207E, R211K	B
Falloon (2000)	JF08	JF08-(-)6w	AF227719	AZT, DDI, DDC, D4T, 3TC	None	D67G, K70R, M184V, T215F, K219Q		K43KQ, K64R, T69N, V118I, I135M, G196N, T200I, I202V, E204Q, Q207E, R211K, F214L, V245T	B
		JF08-12w	AF227720	AZT, DDI, DDC, D4T, 3TC, ABC	None	M41L, D67G, K70R, L74I, M184V, T215F, K219Q		K43Q, K64R, T69N, V118I, F171Y, G196N, T200I, I202V, E204Q, Q207E, R211K, F214L, L228LH, V245T	B
	JF09	JF09-0w	AF227721	AZT, DDI, DDC, D4T, 3TC	None	D67G, T69D, K70R, M184V, T215F, K219Q		S68G, V118I, I135T, Q197QK, F214L, D218DE	B
		JF09-9w	AF227722	AZT, DDI, DDC, D4T, 3TC, ABC	None	D67G, T69D, K70R, M184V, T215F, K219Q		S68G, V118I, I135T, Q197K, F214L, D218E	B
Parkin (2000)	SD-6	SD-6_5	AF294522	NRTI, D4T, 3TC, ABC	None	D67G, K70R, M184V, T215TA, K219Q		K20R, S68G, K122E, I135IT, I202IV, Q207AE, R211KQ, T286A	B
		SD-6_9	AF294523	NRTI, D4T, 3TC, ABC	None	D67G, K70R, M184V, K219Q		K20R, S68G, K122E, I202IV, E203ED, Q207AE, R211KQ, F214FL, T215X, T286A	B
		SD-6_18	AF294524	NRTI, D4T, 3TC, ABC	None	D67G, K70R, M184V, K219Q		K20R, S68G, K122E, I135IT, I202IV, Q207AE, R211KQ, T215X, T286A	B
Albrecht (2001)	ACTG364_1242	1242		AZT, DDC, 3TC	None	D67G, K70R, M184V, T215Y, K219E		V35T, S68G, K166KR, Q207E, A272P, V276X, Q278A	B
	ACTG364_2877	2877		AZT, 3TC	None	D67G, K70R, M184V, T215FV, K219Q		K20R, S68SG, R211S, D218DE, E224ED, K281R, I293V, E297K	B
	ACTG364_35	35		AZT, DDC, DDI, 3TC	None	D67G, K70R, M184V, K219Q		V35M, K64H, T69N, V118I, F214L, D218E, V245T	B
	ACTG364_777	777		AZT, DDI, 3TC	None	M41ML, D67G, T69D, K70R, M184V, T215FV, K219Q		K20KR, S48T, K64H, V118I, I135T, E138EQ, F214L, D218DE, L228H, K259K*, A272AS, Q278H, A288T, T290TS	B
	ACTG364_8	8		AZT, DDI, 3TC	None	D67G, K70R, M184V, T215F, K219Q		K20R, V35IM, K43Q, K64N, K102Q, K104KN, I135L, S162H, T200A, Q207QH, D218E, L228LH, V245K, A272P, T286A	B
Gonzales (2001)	CA1447	CA3863	AY030585	AZT, 3TC, D4T	None	M41L, D67G, L210W, T215Y		A98S, K102Q, K122E, A272P, I293V	B
	CA2196	CA7968	AY030820	AZT, DDI, 3TC	None	D67G, K70R, M184V, T215F, K219Q		S68G, I142V, Q207E, D218E, V245K, I293V	B
	CA3914	CA9117	AY030917	AZT, 3TC, DDC, D4T, DDI	None	D67G, T69D, K70R		K64R, I132IM, N137X, I142V, G196E, R211A, F214L, V245M	B
	CA4743	CA11613	AY031405	3TC, D4T	None	M41L, D67G, T69D, K70R, M184V, T215F		K20R, S68G, I135T, S162CY, I178M, Q207E, Q258Q*, N265NI, A272P, A288S, E297K	B
	CA6805	CA16855	AY032538	D4T, DDI	None	D67G		V35L, R83K, D123E, I135V, D177E, I195M, R211K, I293V	B
Masquelier (2002)	apv13	apv13M4	AY134468	AZT, 3TC	None	A62V, D67G, M184V		R83K, I135T, S162C, Q174H, D177E, G196E, Q197K	B
Gonzales (2003)	CA626	CA1193	AF513998	AZT, DDI, D4T, 3TC	None	D67G, K70G, F77L, F116Y, Q151M, M184V		S68N, Q207E, F214L, T286A	B
	CA6805	CA21219	AF514245	D4T, DDI	None	D67G		V35L, R83K, D123E, I135V, D177E, I195IM, R211K, I293V	B
Shafer (2003)	A384_3191	3191b	EF548372	AZT, 3TC	None	D67G, K219Q		E6EK, K11KR, V35T, K64N, T200TI, D218E	B
Kuritzkes (2004)	KDR_pat268	DRK_A0371	AY528188	AZT, 3TC	None	D67G, M184V		T39TA, V60VI, S68G, D121H, K122E, I135T, K166R, D177E, G196E	B
Machado (2004)	cs151	cs151	AY313421	AZT, DDI	None	M41L, D67G, T69S_SG, T215Y		A158S, D177E, T200A, R211T	B
Garcia-Bujalance (2005)	GBS_26	GBS_26	AY872361	D4T, 3TC	None	D67G, K70R, M184V, K219E		S68G, T69N, T84P, D113H, D123DE, I135T, S162C, Q174QR, G196E, R211K	B
Rhee (2005)	CA4743	CA24343	AY801386	3TC, D4T	None	M41L, D67G, T69D, K70R, M184V, T215F		T7TA, K20R, T39TA, S68G, I135T, S162Y, Q174QH, I178M, Q207E, L228LHQ, A272P, A288S, E297K	B
		CA24345	AY802704	3TC, D4T	None	M41L, D67G, T69D, K70R, M184V, T215F		T7TA, K20KR, T39TA, S68G, I135T, S162Y, Q174QH, I178M, Q207E, L228X, A272P, A288S, E297K	B
		CA34921	AY801387	3TC, D4T	None	M41L, D67G, T69D, K70R, M184V, T215F		T7TA, K20KR, T39TA, S68G, I135T, S162Y, Q174H, I178IM, Q207E, L228X, A272P, A288S	B
		CA42712	AY801388	3TC, D4T	None	M41L, D67G, T69D, K70R, M184MV, T215F		T7TA, T39TA, S68G, I135T, S162Y, Q174H, Q207E, L228Q, V245VM	B
	CA4782	CA20180	AY801400	AZT, D4T, 3TC, ABC	None	D67G, K70R, M184V, T215F, K219Q		K20R, S68G, I135V, F214L, D218DE	B
		CA34721	AY801401	AZT, D4T, 3TC, ABC	None	D67G, K70R, M184V, T215F, K219Q		K20R, S68G, I135V, F214L, D218E, A272P, T286A, A288S, I293V, E297A	B
	CA7848	CA19878	AY801794	AZT, DDI, D4T, 3TC, ABC	None	M41L, D67G, T69D, V75VL, M184I, L210W, T215Y, K219R		K43KN, E44D, V60I, V118I, K122E, D123E, I135T, I142V, G196E, I202X, E203EK, Q207E, H208Y, R211K, H221HY, K223KE, V245K, A272P	B
		CA23659	AY801795	AZT, DDI, D4T, 3TC, ABC	None	M41L, D67G, T69D, M184I, L210W, T215Y, K219R	F227FL	T39TP, K43KN, E44D, S48SP, V60I, V118I, K122E, D123E, I135T, I142V, G196E, E203K, Q207E, H208Y, R211K, K223E, V245K, A272P	B
	CA8037	CA20166	AY801921	AZT, DDC, D4T, 3TC	None	D67G, K70R, M184V, K219Q		K64H, T69N, T200A, R211K, F214L, D218E, K277R	B
		CA48180	AY801922	AZT, DDC, D4T, 3TC	None	D67G, K70R, M184V, K219Q		K64H, T69N, V118I, Q174QR, V179VI, T200A, R211K, F214L, D218E, K277R, I293V, T296TS, E297R	B
	SWC-8546	8546-3393		AZT, DDC, 3TC, D4T	None	D67G, T215V, K219Q		V35I, K64H, T69N, A98S, V118I, V179T, T200E, R211K, F214L, S251N	B
	CA16089	CA38299	AY802423	AZT, 3TC	None	D67G, K70KR, M184V		I31L, I94IL, R211K, V245K, S251I, T286A, I293V, E297V	B
	CA17694	CA41631	AY802545	D4T, 3TC	None	M41L, A62V, D67G, M184V, L210W, T215Y, K219R	V108I	K20R, K43Q, E44D, K102S, V106I, T107A, V118I, K122E, Q174E, G196E, H208Y, R211K, K223Q, L228H, E297K, K350E	B
Rhee (2006)	CA8369	CA21096	DQ316615	DDI, DDC, AZT, 3TC	None	D67G, T69D, K70R, M184V, K219Q		K20R, A33G, V118I, K122E, I135T, Q197P, T200A, F214L, T286P, I293V, E297A	B
Rosen-Zvi (2008)	25	00p25-1		AZT, DDI, DDC, 3TC, D4T	None	M41L, D67G, T69D, T215Y		K20R, V60I, S68G, R83K, D123E, I135V, R211K, V245E, A272P, E297K	B
Dumans (2009)	RENA686	RENA686	FJ405043	AZT, 3TC	None	D67G, K70R, M184V, T215F, K219E	K103N	K20R, V35M, S68G, R83K, D123E, V245K, A272P, K281R, E297R, Q334D	B
Rhee (2009)	CA14225	CA34363	FJ983352	AZT, DDC, 3TC, D4T	None	M41L, D67G, T69D, L210W, T215Y, K219R		E6D, V60VI, V118I, K122E, D123E, I135V, I142V, S162C, R211K, V245K, I293V	B

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