Reverse Transcriptase Inhibitors

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Reverse Transcriptase Inhibitors

Subtype	B
Gene	RT
Mutation	D67E
Rx	>= 1 NRTI (but no NNRTI)
IncludeMixtures	No

References	11
Patients	20
Isolates	22

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	NRTIs	NNRTIs	NRTIDRMs	NNRTIDRMs	OtherMut	Subtype
Ruiz (1996)	JCS-C41	C41B	Z99331	DDC, AZT	None	M41L, D67E, L210W, T215Y		V35I, S68G, K122E, I135T, T200X	B
		C41W24	Z99330	DDC, AZT, 3TC	None	M41L, D67E, L210W, T215Y		V35I, S68G, K122E, I135T, T200X	B
Hammer (1997)	ACTG320_2648	2648		AZT, DDI, DDC, D4T, 3TC	None	M41L, A62V, D67E, L210W, T215Y		K43Q, I50IV, S68MV, W88C, V118I, K122E, S162SG, N175Y, R211K, A272P, K277R, I293IV, I329V, G333E, G359S, A371V, A376T, A400T, K451KR, D460N, Q487X	B
	ACTG320_4281	4281		AZT	None	M41L, D67E, T215Y		E6EG, V35T, V60I, S68G, D86DE, I135V, Q197E, T200A, Q207E, A272S, A288S, I293V, T338S, R356K, M357T, G359S, T377M, S379C, A400AT, T403TI, E404D, F416FY, A437V, K465R, L469I, L491S	B
	ACTG320_989	989		DDC, AZT, D4T	None	M41L, D67E, L210W, T215Y		V35I, T39A, S68G, K104KN, V118VI, I135T, W153WL, K166R, T200S, R211RK, V245T, A272P, I293V, I329IL, Q334D, K347Q, G359S, K390R, T403I, V435VA, L452M, S468P	B
Cabana (1999)	Cab-b	B0	AF102334	DDC, AZT	None	M41L, D67E, L210W, T215Y		K43R, S68G, K122P, D123E, I135T, S162C, D177E, R211K	B
		B58	AF102335	DDC, AZT, 3TC, D4T	None	M41L, D67E, V75M, F77L, M184V, L210W, T215Y		E40F, K43E, S68G, V118I, K122P, D123E, I135T, L149I, S162C, D177E, Q207E, R211K	B
Albrecht (2000)	ACTG303_496	496RT_f1		AZT, DDI, 3TC	None	M41L, D67E, L210W, T215Y		E44D, S68G, K173E, I178L, Q207E, V245K, A272P	B
Balotta (2000)	CB-4	CB-4	AF186769	AZT, DDC, D4T, 3TC	None	D67E, T69S_SG, L210W, T215Y	A98G	P4S, K20R, V118I, K122E, K154KE, K173T, G196E, R211K, L228H	B
Albrecht (2001)	ACTG364_1212	1212		DDI, AZT	None	A62V, D67E, K70R, V75T, T215TI, K219Q		K20R, T27S, I37L, S68G, V118I, K122E, E203D, F214L, L228H, A272P, Q278QE, T286A	B
	ACTG364_3308	3308		AZT, DDI, 3TC	None	M41L, A62V, D67E, K70R, F116Y, M184MIV, L210W, T215Y		V35I, T39TA, T69S, V90I, V118I, K122KE, S162C, E203EK, R211S, L228H, A272P, K277R, E300X, L301X, A304X	B
	ACTG364_5710	5710		AZT, DDI, 3TC	None	A62V, D67E, K70R, T215F		V35I, T69S, V118VI, I135T, K173N, G196E, A272P, K277R, Q278H, E297K	B
Gonzales (2001)	CA4723	CA11585	AY031385	AZT, DDI, DDC, 3TC	None	M41L, D67E, M184V, L210W, T215Y		E44D, S68G, D123E, D177E, I178M, R211K, Q278QH	B
	CA4782	CA11674	AY031442	AZT, D4T, 3TC	None	D67E, K70R, M184V, K219Q		K20R, S68G, I135V, F214L, A272P, T286A, A288S, I293V, E297A	B
	CA5965	CA14730	AY032212	AZT, 3TC	None	M41L, D67E, M184V, L210W, T215Y		K11R, E44D, S68G, K122E, I135T, I142IV, R211K, I293V	B
Katzenstein (2001)	ACTG302_1893	1893RT_f1		AZT, DDI, 3TC	None	M41ML, A62V, D67E, K70R, F116Y, M184I, L210W, T215Y		V35VI, T69S, R83RK, V90I, V118I, S162C, T165TI, R211S, L228H, A272P, K277R, R284RI	B
	ACTG302_3588	3588RT_f1		AZT, DDI, 3TC	None	A62V, D67E, K70R, T215F		K20KT, V35I, T69S, I135T, A158AS, K173N, G196E, A272P, K277R, Q278H, E297K	B
Clevenbergh (2002)	CP0937	CP0937	AF519428	D4T, DDI	None	A62V, D67E, T69S_SG, K70R, T215F		V118VI, K122E, D123S, D177DE, Q207E, R211K	B
Machado (2004)	cs160	cs160	AY313394	AZT, DDI, 3TC	None	M41L, D67E, V75M, F77L, M184V, L210W, T215Y		T39A, E44D, S68G, V118I, D123E, I135T, E138A, I142T, Q197L, R211K	B
Montes (2004)	MB_patGUZ	01_GUZ714	AJ577908	ABC, AZT, 3TC	None	D67E, K70R, Y115F, M184V		K49R, V90I, D123E, T165I, I202V, E204D, F214L	B
	MB_patGUZM	01_GUZ814	AJ577909	ABC, AZT, 3TC	None	D67E, K70R, Y115F, M184V		K49R, V90I, D123E, T165I, I202V, E204D, F214L	B
	MB_patGUZM J	01_GUZ914	AJ577910	ABC, AZT, 3TC	None	D67E, K70R, Y115F, M184V		K49R, V90I, D123E, T165I, I202V, E204D, F214L	B

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