<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype B
Gene RT
Mutation K65R
Rx >= 1 NRTI
(but no NNRTI)
IncludeMixtures No
References 25
Patients 46
Isolates 51
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Ruiz (1996)JCS-C13C13BZ99306AZT, DDINoneK65R, V75I, F77L, F116Y, Q151M V35M, T39K, K43E, S68G, T69I, K70X, K102Q, K122E, K166R, T200A, R211G, V245E, D250EB
  C13W24Z99307AZT, DDI, 3TCNoneK65R, V75I, F77L, F116Y, Q151M, M184V V35M, T39K, K43E, S68G, T69I, K70X, K102Q, K122E, K166R, T200A, R211G, V245E, D250EB
Winters (1997)143P11143P11W72AF013451AZT, DDINoneK65R, K70R, L74V, K219KQ D121H, K122E, I142V, R172X, Q174X, I178M, V179I, R211K, K238XB
 143P12143P12W104AF013459AZT, DDINoneK65R S68G, T69I, R83K, Q207E, R211K, L228KB
 143P13143P13W104AF013463AZT, DDINoneK65R V60I, S68G, R83K, D123EB
Cabana (1999)Cab-lL0AF102366AZT, 3TC, DDINoneK65R, K70R, V75I, F77L, F116Y, Q151M T39K, K43E, S68G, T69I, K102Q, K122E, K166R, R211GB
  L39AF102367AZT, 3TC, DDI, D4TNoneK65R, K70R, V75I, F77L, Y115F, F116Y, Q151M, M184V T39K, K43E, S68G, T69I, K102Q, K122E, K166R, T200A, R211G, L228QB
  L47AF102368AZT, 3TC, DDI, D4TNoneK65R, K70R, V75I, F77L, Y115F, F116Y, Q151M, M184V, K219Q K43E, S68G, T69I, K102Q, K122E, K166R, T200A, R211G, L228KB
Albrecht (2000)ACTG303_1212RT_f1 AZT, DDI, 3TCNoneA62V, K65R, K70R, V75I, F77L, F116Y, Q151M, M184V T7P, V8G, V35VI, S68G, T69A, R83K, D123G, K173R, Q174K, V245E, A272P, I293V, L295T, E297AB
Balotta (2000)CB-2CB-2AF186767AZT, DDI, 3TC, DDC, D4TNoneK65R, K70R, V75I, F77L, F116Y, Q151M V35I, S68G, R83K, D123E, K166R, D177E, G196E, R211KB
Baxter (2000)GART-G87GART-87 NRTI, AZT, 3TCNoneK65R, K70R, V75I, F77L, Y115F, F116Y, Q151M, M184V, K219E S68G, K122E, Q174K, D177E, T200A, Q207K, R211A, L234XB
Miller (2000)MV-101MV-101wk24 ABCNoneK65R, M184V V35T, I142V, W153M, A158AT, E169DB
 MV-140MV-140wk16 ABCNoneK65R, Y115F, M184V I50V, R83K, K122E, E169D, D186DN, G196E, T200I, R206RKB
 MV-168MV-168wk16 ABCNoneK65R, M184V V35I, S68G, K122E, I135T, Q145X, G196E, E204DB
  MV-168wk48 ABC, AZT, 3TCNoneK65R, V75VIL, F77L, Y115F, Q151M, M184V V35I, S68G, K122E, I135T, G196E, E204DB
 MV-172MV-172wk16 ABCNoneK65R V35I, R83K, D123E, A158AT, E169X, Q174LB
Albrecht (2001)ACTG364_766766 DDI, AZTNoneM41L, K65R S68N, F124Y, I178L, Q207E, V245KB
Delgado (2001)ED_V24ED_V24AY016934AZT, 3TCNoneM41L, A62AV, K65R, V75I, F116Y V60I, S68R, D123E, I132IV, Q151X, S162CY, E169D, I178L, Q207EB
Gonzales (2001)CA1166CA2649AY030474AZT, DDC, D4T, 3TCNoneK65R, K70R, V75I, F77L, Y115F, F116Y, Q151M, K219KE E6D, V35IM, S68G, K122E, I135T, T200I, I202V, T216TI, V245M, A272P, K275KR, E297DB
 CA1525CA4367AY030644DDINoneK65R K11E, T200I, R211K, K249Q, A272P, I293VB
Katzenstein (2001)ACTG302_33293329RT_f1 DDI, AZT, 3TCNoneK65R, L74LV Q174QH, F214L, K277R, I293V, E302DB
 ACTG302_996996RT_bl AZT, DDINoneK65R D17DA, W24WG, A98S, K102Q, D123E, I135T, S162A, H221HY, V245RB
Brindeiro (2002)TVGG8TVGG8AY145786AZT, DDI, 3TC, D4TNoneK65R, K70R, V75I, F77L, Y115F, F116Y, Q151M, K219E K20R, S68G, I135T, R172K, D177E, T200A, R211K, V245M, A272P, Q278H, I293V, E297AB
Gibb (2002)DMG4242_w26 ABC, 3TCNoneK65R, M184V P4PS, K122E, I135K, G196E, V245E, A272P, T286P, E297K, V317A, M357T, A376VB
  42_w42 ABC, 3TCNoneK65R, L74LV, Y115YF, M184V K122E, D123DN, I135K, G196E, V245E, A272P, T286P, E297K, V317A, M357T, A376VB
Romano (2002)MZ-pt38pt38-t0AF493373AZT, DDI, D4T, 3TC, ABCNoneK65R, V75I, F77L, F116Y, Q151M S68G, T69I, E79D, V118VI, D121Y, K122E, S162C, I178M, Q197E, T200A, E204D, R211T, F214LB
Tural (2002)880814880814 AZT, D4T, DDI, 3TCNoneM41L, K65R, V75I, F116Y, Q151M K49R, I50V, V60I, S68G, T69I, K122E, I135T, I142M, T165I, D177E, F214L, V245MB
Gonzales (2003)CA4007CA20207AF514172D4T, DDI, ABC, AZT, 3TCNoneK65R, K70R, V75I, F77L, Y115F, F116Y, Q151M, M184V S68G, D121H, K122E, D177E, E203D, E248D, R284K, T286A, A288S, V292I, I293VB
Roge (2003)ea1ea1-FAY222051ABC, D4T, DDINoneK65R, K219RV179DS68SG, T107TA, D123E, I135T, A158S, E169D, T200A, R211RK, F214LB
 hj2hj2-F1AY222053ABC, D4T, DDINoneK65R S68G, D113X, K122E, S162A, T200A, Q207E, R211KB
 bc3bc3-F2AY222056ABC, D4T, DDINoneK65R S68G, D123E, I135T, I178IM, R211KB
 md4md4-F1AY222058ABC, D4T, DDINoneK65R R83K, R143RI, S162C, D177E, I178L, I195L, Q207E, R211KB
 sm5sm5-FAY222060ABC, D4T, DDINoneK65R I178M, T200AB
Shafer (2003)A384_36163616bEF548806D4T, DDINoneK65RK103SS68SG, K122E, Q174QR, D177DE, I178M, D192N, G196GV, T200TA, Q207E, R211K, V245MB
Dumans (2004)208208AY390155AZT, DDI, 3TC, D4TNoneK65R, K70R, V75I, F77L, Y115F, F116Y, Q151M, K219E S68G, D177EB
Gulick (2004)RG14RG14w64 ABC, AZT, 3TCNoneK65R, M184V S68GB
Delaunay (2005)DC_00808_8004w12DQ286522ABC, TDF, 3TCNoneK65R, M184V V35I, V60I, S68G, D123E, I135T, I178L, V179I, G196E, R211KB
 DC_01919_3007w12DQ286513ABC, TDF, 3TCNoneK65R, M184V, T215E S68G, K102Q, D123E, I135T, D177E, I178M, T200I, R211KB
 DC_TON0300203002w12DQ286510ABC, TDF, 3TCNoneK65R, M184V K122E, I135T, D177E, G196E, I202V, R211S, F214LB
 DC_TON0400604006w12DQ286517ABC, TDF, 3TCNoneK65R, M184V R83K, D123E, I178M, T200A, R211KB
 DC_TON0500805008w12DQ286520ABC, TDF, 3TCNoneK65R, M184V K49Q, F87L, I135L, S162Y, D177E, Y183S, R211KB
 DC_TON0800208002w12DQ286521ABC, TDF, 3TCNoneK65R, M184V E138A, I142T, I202V, R211KB
Gallant (2005)JEG03JEG03_w12DQ199576ABC, TDF, 3TCNoneK65R, M184V R83RK, T200TA, R211K, V245K, K281KR, T286A, E297KB
 JEG18JEG18_w12DQ199591ABC, TDF, 3TCNoneK65R, Y115YF, M184V D123E, I178M, I180V, R211K, A272P, T296TSB
 JEG19JEG19_w12DQ199592ABC, TDF, 3TCNoneK65R, M184V K122E, I135T, R211K, T286TA, A288S, E297KB
 JEG25JEG25_w12DQ199598ABC, TDF, 3TCNoneM41L, K65R, M184V, L210W, T215D V60I, S68G, K122E, I135T, D177E, G196E, I202IV, R211K, V245T, D250E, A272P, K277R, E297AB
 JEG31JEG31_w12DQ199604ABC, TDF, 3TCNoneK65R, M184V K20KR, V35R, S68SDGN, D121Y, K122E, I135T, I142IL, T165I, I178V, E204A, R211K, F214L, V245E, A272P, K277R, V292I, I293V, E297TB
Ochoa de Echaguen (2005)B-1204B-1024AY833594AZT, DDI, D4T, ABCNoneK65R K49R, V60VG, S68G, R83K, V106I, D123E, D177E, I178V, T200A, I293V, E297AB
Rhee (2005)CA14410CA38239AY802337TDF, 3TC, DDINoneM41L, K65R, M184V, T215D V60I, S68G, D123E, I202V, Q207QR, R211A, K259KR, I293V, E297AB
 CA14756CA35256AY802419ABC, AZT, 3TC, D4T, DDINoneK65R, M184V S68G, I142M, D177E, I178M, Q207A, K238R, T286A, I293VB
Rosen-Zvi (2008)803p8-1 AZT, D4T, 3TC, ABC, TDFNoneK65R, K70KEGR, Y115F, M184V V60I, S68SN, T69TN, D121H, K122E, I135T, D177E, R211K, A288S, I293V, E297K, K311R, Q334EB