Reverse Transcriptase Inhibitors

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Reverse Transcriptase Inhibitors

Subtype	B
Gene	RT
Mutation	A62V
Rx	>= 1 NRTI (but no NNRTI)
IncludeMixtures	No

References	30
Patients	75
Isolates	86

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	NRTIs	NNRTIs	NRTIDRMs	NNRTIDRMs	OtherMut	Subtype
Shafer (1995)	JIDP26	JIDP26W88	AF021308	AZT, DDI	None	A62V, V75I, F77L, F116Y, Q151M, K219E		T39A, S68G, A98S, I135V, R172K, Q174H, R211G, F214L, V245M	B
Hammer (1997)	ACTG320_2648	2648		AZT, DDI, DDC, D4T, 3TC	None	M41L, A62V, D67E, L210W, T215Y		K43Q, I50IV, S68MV, W88C, V118I, K122E, S162SG, N175Y, R211K, A272P, K277R, I293IV, I329V, G333E, G359S, A371V, A376T, A400T, K451KR, D460N, Q487X	B
Winters (1998)	J-A	J-A	AF096882	AZT, DDI, D4T, 3TC	None	M41L, A62V, T69A_SS, M184V, T215Y		K20R, K43N, V118VI, K122KE, S162C, D177E, R211K, L228LH	B
Albrecht (2000)	ACTG303_12	12RT_bl		AZT, DDI	None	A62V, V75I, F77L, F116Y, Q151M		V35VI, S68SG, T69A, R83K, K173R, Q174K, V245E, A272P, I293V, E297A, E302X	B
		12RT_f1		AZT, DDI, 3TC	None	A62V, K65R, K70R, V75I, F77L, F116Y, Q151M, M184V		T7P, V8G, V35VI, S68G, T69A, R83K, D123G, K173R, Q174K, V245E, A272P, I293V, L295T, E297A	B
	ACTG303_1349	1349RT_f1		AZT, DDI, 3TC	None	A62V, V75I, F77L, Y115F, F116Y, Q151M, M184V, K219E		V35I, S68G, D123E, S162T, V245M, K277R, Q278H, I293V	B
Bacheler (2000)	LB3-P25	P25-0		NRTI	None	A62V, V75I		K20R, R83K, K103R, G196E, T200A, R211K	B
Balotta (2000)	CB-187	CB-187	AF252038	D4T, 3TC, DDC, AZT, DDI	None	M41L, A62V, L210W, T215Y		T27TA, K43Q, E44D, K49R, V118I, K122E, E138A, S162C, Q174N, I178F, H208Y, R211K, L228H	B
	CB-230	CB-230	AF252086	DDC, AZT, D4T, 3TC, DDI	None	A62V, M184V, L210W, T215Y		R83K, D123E, R211K	B
	CB-295	CB-295	AF252011	AZT, D4T, 3TC, DDI	None	M41L, A62V, L74V, M184V		V35I, S48T, D123E, G196GDE, T200A	B
	CB-1	CB-1	AF186766	DDC, AZT, 3TC, D4T	None	A62V, V75I, F77L, F116Y, Q151M, M184V, K219Q		W24WG, E40K, K43N, I50IF, E53D, S68G, T107TP, V118I, D121H, K122E, I178L, T200A, I202V, R211T, F214L	B
Coakley (2000)	EC34	EC3480w		D4T, DDI	None	A62V, V75I, F77L, F116Y, Q151M		K122E, I142D, R143W, A158S, I178M, R211G, A272P, T286A, I329V	B
Shulman (2000)	CA624	CA9919	AY802614	DDI, D4T, 3TC, AZT	None	A62V, K70G, V75I, F77L, Y115F, F116Y, Q151M, M184V		S68G, T69K, K122E, K166R, D177E, R211K, K277R, I293V, E297K	B
Albrecht (2001)	ACTG364_1208	1208		DDI, AZT	None	A62V, K70N, V75I, F77L, F116Y, Q151M		E6D, T58N, S68G, D123E, I135T, S162C, D177E, I202V, Q207E, V245E, K277R	B
	ACTG364_1212	1212		DDI, AZT	None	A62V, D67E, K70R, V75T, T215TI, K219Q		K20R, T27S, I37L, S68G, V118I, K122E, E203D, F214L, L228H, A272P, Q278QE, T286A	B
	ACTG364_3308	3308		AZT, DDI, 3TC	None	M41L, A62V, D67E, K70R, F116Y, M184MIV, L210W, T215Y		V35I, T39TA, T69S, V90I, V118I, K122KE, S162C, E203EK, R211S, L228H, A272P, K277R, E300X, L301X, A304X	B
	ACTG364_3907	3907		DDI, AZT	None	M41L, A62V, V75T, T215Y	L100LI	V21I, I178IM, Q197QP, R211K, D218E, A272P	B
	ACTG364_5710	5710		AZT, DDI, 3TC	None	A62V, D67E, K70R, T215F		V35I, T69S, V118VI, I135T, K173N, G196E, A272P, K277R, Q278H, E297K	B
Gonzales (2001)	CA624	CA1189	AY030418	DDI, D4T, 3TC, AZT	None	A62V, K70G, V75I, F77L, Y115F, F116Y, Q151M, M184EV		S68G, T69N, V148VE, K166KR, D177DE, I178M, Y183Y*	B
	CA1388	CA3636	AY030542	AZT, 3TC, DDI, D4T	None	A62V, V75T, M184V, L210LW		V8I, D123E, I135V, S162C, R211K, V245M	B
	CA1442	CA3853	AY030580	D4T, 3TC	None	A62V, V75T, M184V		D123E, I135IT, S162C, T200I, R211RK	B
	CA1867	CA4996	AY030771	D4T, 3TC, DDI, AZT	None	M41L, A62V, M184V, L210W, T215Y		K43Q, V118I, I135V, I142IV, S162A, R211K, L228R, K238KR, I257X, Q258X	B
	CA2103	CA7758	AY030810	AZT, DDI, DDC, D4T, 3TC	None	M41L, A62V, D67N, L74I, M184V, L210W, T215F, K219Q	K103N	V35L, K64KR, K122E, K173E, I178L, V179VI, D218E, L228H	B
	CA2321	CA8419	AY030865	AZT, 3TC, D4T	None	A62V, M184V	V179D	V35T, K103R, I135T, Q174E, R211K, T215X, K259KR, N265NT, A272S	B
	CA3878	CA9070	AY030883	DDI, D4T, 3TC	None	M41L, A62V, M184V, T215Y		K43N, L109LI, K122E, S191SA, L193LF, T200I, I202IL, E203ED, R206R*, D218E	B
	CA4418	CA10627	AY031272	AZT, 3TC, ABC	None	A62V, M184V, T215Y		I132IR, I135T, I142V, R211K, V245K, E248D, T286A, I293V, E297K, A304G	B
	CA4461	CA10930	AY031305	AZT, DDI, 3TC	None	M41L, A62V, M184V, L210W, T215Y		T39A, E44D, A98S, D123E, I178L, E203K, Q207E, H208Y, R211K, I293V, M357T, E370D, T386I, A400L, K451R, D460N, R461K, V467I, L491S, E529D	B
	CA5015	CA12286	AY031590	DDC, D4T, AZT, 3TC	None	A62V, M184V, T215Y		K20R, T69S, K122E, I142V, V245R, S251I	B
	CA5278	CA12941	AY031835	AZT, DDI, DDC, 3TC	None	A62V, Q151KM, M184V		K20R, S68ST, F87FL, K122E, I135T, G155GR, I159IL, S162CW, F214L	B
	CA5407	CA13138	AY031961	AZT, 3TC	None	A62V, M184V		K20KR, K43KR, K122E, I135RT, N137NS, R211K, F214L, L228R, E291D, E297R	B
	CA5410	CA13142	AY031964	AZT, DDC, 3TC, D4T	None	M41L, A62V, M184V, T215Y		V35L, T39A, K122E, T139K, P140T, E169D, K173E, I178L, G196E, T200A, Q207E, A272P, K277R, I293V	B
	CA6425	CA15931	AY032379	DDC, D4T, 3TC	None	M41L, A62V, V75T, M184V		K32N, D123E, I135R, V179I, T253TA, R284K, I293V	B
	CA6825	CA16887	AY032557	DDC, AZT, 3TC, D4T	None	A62V, K70R, M184V		T69N, W88WC, K122E, D123E, I135IT, E169D, I202V, Q207N, R211K, F214FL, A272P, E297K, A299AG	B
Katzenstein (2001)	ACTG302_1444	1444RT_f1		DDI, AZT, 3TC	None	A62V, L74V, V75T, M184V		I37L, V90I, I135M, S162A, Q197R, V245M, A288S, I293V, E297K	B
	ACTG302_1893	1893RT_f1		AZT, DDI, 3TC	None	M41ML, A62V, D67E, K70R, F116Y, M184I, L210W, T215Y		V35VI, T69S, R83RK, V90I, V118I, S162C, T165TI, R211S, L228H, A272P, K277R, R284RI	B
	ACTG302_3588	3588RT_bl		AZT, DDI	None	A62V, K70R, T215F		V35I, T69S, R83K, I135T, A158AS, K173N, G196E, A272P, K277R, E297K, E302D	B
		3588RT_f1		AZT, DDI, 3TC	None	A62V, D67E, K70R, T215F		K20KT, V35I, T69S, I135T, A158AS, K173N, G196E, A272P, K277R, Q278H, E297K	B
Perez (2001)	EP-2000	EP-2000	AF320524	NRTI	None	A62V, L210W, T215Y		I63*, K64R, T69S, D121Y, K122E, A158S, S162D, F171L, R172E, K173N, Q174K, I178L, Q207E, R211K	B
Servais (2001)	JS21	JS98025	AJ401795	AZT, DDI, D4T, 3TC	None	A62V, T69S_SS, K70R, M184I, L210W, T215Y		K64R, D123E, Q197E, E203K, R211K, F214W, D218H, I244L	B
		JS98158	AJ401805	AZT, DDI, D4T, 3TC	None	A62V, T69S_SS, K70R, M184I, L210W, T215Y		K64R, V118I, D123E, Q197E, E203K, R211K, F214W, D218H, I244L, S251T	B
		JS98287	AJ401814	AZT, DDI, D4T, 3TC	None	A62V, T69S_SS, K70R, M184I, L210W, T215Y		K64R, V118I, D123E, Q197E, E203K, R211K, F214W, D218H, I244L, E248K	B
		JS98465	AJ401829	AZT, DDI, D4T, 3TC	None	A62V, T69S_SS, K70R, M184I, L210W, T215Y		L34F, S48L, K64R, V118I, D123E, I142T, Q197E, E203K, R211K, F214L, D218H, L228R, I244L	B
Brindeiro (2002)	TVSP19	TVSP19	AY145815	AZT, 3TC, D4T	None	M41L, A62V, M184V, T215F	A98G	V106I, K122E, I135T, F214L, K249Q, A272P, K277R, E297A, V317A	B
	TVGG19	TVGG19	AY145790	AZT, 3TC, D4T	None	A62V, M184V		M16V, K122E, D123N, I135T, D177E, T200E, I202V, R211K, V245M, A272P, V276I, I293V	B
Clevenbergh (2002)	CP0937	CP0937	AF519428	D4T, DDI	None	A62V, D67E, T69S_SG, K70R, T215F		V118VI, K122E, D123S, D177DE, Q207E, R211K	B
	CP1902	CP1902	AF519424	D4T, 3TC	None	A62V, V75I, F77L, Y115F, F116Y, Q151M	Y181C	T69N, K122E, K173Q, Q174R, I202V, Q207E, R211K, V245T	B
Masquelier (2002)	apv13	apv13M4	AY134468	AZT, 3TC	None	A62V, D67G, M184V		R83K, I135T, S162C, Q174H, D177E, G196E, Q197K	B
Tural (2002)	119733	119733		AZT, DDC, 3TC, D4T	None	M41L, A62V, M184V, L210W, T215Y		K20R, K43E, E44A, K166R, G196E, E203D, H208Y, K223Q, L228R	B
	140180	140180		AZT, DDC, 3TC, D4T	None	M41L, A62V, M184V, T215Y		T69S, K122E, I135T, S162X, Q207E, L228H	B
	880307	880307		3TC, D4T	None	A62V, M184V		K49R, D123E, I135T, E169D, Q197E, T200I, R211K	B
	880807	880807		DDC, AZT, 3TC, D4T	None	A62V, M184V, T215Y		E29G, R83K, R211K	B
	881217	881217		AZT, DDI, 3TC, D4T	None	A62V, D67N, K70R, M184V, T215F, K219Q		K20R, T39A, I135T, K166R, G196E, E204K, R211S, F214L	B
	881302	881302		DDC, AZT, 3TC, D4T	None	A62V, D67N, K70R, M184V, T215V, K219Q		I50V, P119A, F124L, I135V, T200A	B
Venturi (2002)	GV-13	GV-13.1	AF517265	AZT, 3TC	None	A62V, T69S_SS, M184V, L210W, T215Y		D123E, K166R, R211K	B
	GV-25	GV-25.1	AF517277	D4T, 3TC	None	A62V, M184V		I31L, R83K, V118VI, K122P, I132L, I135T, I142V, D177E, T200I, F214L	B
Gonzales (2003)	CA1157	CA5071	AF514025	AZT, DDC, DDI, D4T, 3TC	None	M41L, A62V, D67N, T69D, M184V, L210W, T215Y, K219KR		K20R, V35I, K43E, E44A, V118I, K122E, I135T, R211K, L228H	B
	CA5462	CA20101	AF514227	AZT, 3TC	None	A62V, M184V, L210LW, T215F		E6D, K122E, I135T, E203EK, Q207E, R211K, R284K, I293V, E297A	B
Gonzales (2003)	CA6434	CA15945	AY032387	AZT, 3TC, NRTI, D4T, DDI	None	A62V, V75I, F77L, F116Y, Q151M		K20R, K32E, V35I, K49R, I135V, S162CW, E169D, Q207E, R211K, A272P, I293V	B
	CA7052	CA17358	AF514250	AZT, D4T, DDI	None	A62V, K65KR, V75I, F77L, Q151M		A33V, V35T, S68G, K122E, D123N, I178L, T200A, H221HY, E248D, A272P, Q278QE, I293V, A299AG, A304G	B
Shafer (2003)	A384_4002	4002b	EF548429	AZT, 3TC	None	A62V, M184V		S48T, K122Q, S162H, D177E, V179I, E194EG, G196E, Q207G, R211K, P243A	B
Dumans (2004)	197	197	AY390154	AZT, DDI, D4T, 3TC	None	A62V, V75I, F77L, F116Y, Q151M, M184V, K219Q	E138K	K49R, I50V, S68G, K101Q, R172K, V179A, I202V, F214L	B
Kuritzkes (2004)	KDR_pat190	A0255	AY528072	AZT, 3TC	None	A62V, M184V		D113DY, D123DEKN, K166R, R211RK	B
Machado (2004)	cs127	cs127	AY313377	AZT, DDI, 3TC	None	A62V, M184V, T215Y		S48T, K49R, K122E, D123E, I135T, I178M	B
	cs157	cs157	AY313424	AZT, DDI	None	A62V, V75I, F77L, F116Y, Q151M		K122E, I202V, F214L	B
Montes (2004)	MB_patMAR	00_MAR712	AJ577943	AZT, DDI, D4T, 3TC	None	M41L, A62V, M184V, T215F		D123E, D177E, I178L, R211K, F214L	B
	MB_patAVO	01_AVO720	AJ577732	DDC, AZT, 3TC, D4T	None	A62V, M184I, L210W, T215S	A98G	R83K, I135V, S162C, T165V, I202V	B
Garcia-Bujalance (2005)	GBS_31	GBS_31	AY872366	DDC, AZT, 3TC	None	A62V, V75I, M184V		E40ED, K43N, A98S, G196E, R211K, V245E	B
Rhee (2005)	CA789	CA20223	AY800704	AZT, DDC, D4T, 3TC	None	M41L, A62V, V75T, M184V, T215Y		I37L, S68G, K122E, D123N, I178M, T200A, E204D, Q207D, R211K, A288S, I293V	B
	CA2197	CA7970	AY801140	AZT, 3TC, D4T	None	A62V, T69S_SS, K70R, M184V		Q85QH, A98S, D123E, D177E, G196R, Q207E, R211K, V245K	B
	CA3878	CA24613	AY801182	DDI, D4T, 3TC	None	M41L, A62V, M184V, T215Y		K43N, L109I, K122E, T200I, D218E, Q278H, T286A, I293V	B
		CA34810	AY801183	DDI, D4T, 3TC	None	M41L, A62V, M184V, T215Y		K43N, L109I, K122E, T200I, D218E, Q278H, T286A, I293V	B
	SWC-5729	5729-3376		AZT, 3TC, D4T	None	M41L, A62V, T69S_SS, M184I, L210W, T215Y		V35M, K43E, V118I, K122E, I135T, V245Q	B
		5729-4183		AZT, 3TC, D4T	None	M41L, A62V, T69S_SS, M184I, L210W, T215Y		V35M, K43E, V118I, K122E, I135T, V245Q	B
	CA5462	CA13455	AY801581	AZT, 3TC	None	A62V, M184V, T215F		E6D, K122E, I135L, Q207E, H208HY, R211K, R284K, I293V, E297A	B
	CA6825	CA48188	AY801706	DDC, AZT, 3TC, D4T, TDF	None	A62V, K70R, M184V, K219Q		K49KR, T69N, K122E, D123E, I135T, E169D, T200A, Q207N, R211K, F214L, A272P, I293IV, E297KQ	B
	CA8050	CA20184	AY801930	AZT, 3TC, D4T, DDI	None	M41L, A62V, V75T, M184V, L210W, T215Y		K122E, K173KR, V245E, K281R, I293V	B
	CA9773	CA23996	AY802107	AZT, DDI, D4T, 3TC	None	M41L, A62V, D67DN, V75T, M184V, T215Y		I31IL, V90I, K102R, D123E, I142V, V179I, Q207N, T286A, I293V, E297K	B
	CA9937	CA24567	AY802202	AZT, 3TC	None	M41L, A62V, M184V, L210W, T215Y		T7A, T39A, E44ED, R83K, D121H, K122E, K166R, D177E, I180IV, G196E, T200A, R211K, K277R, K281R, T286A, A288S, I293IV, E297K	B
	CA9958	CA38181	AY802211	AZT, 3TC	None	A62V, M184V		K49R, I50V, R211T, T286A	B
	CA14612	CA35020	AY802391	AZT, 3TC	None	A62V, M184V, T215FY		K49R, V90I, K122KE, D123DN, S162N, Q174R, R211K, R284K, I293V	B
	CA16544	CA39278	AY802525	D4T, 3TC	None	A62V, M184V		K122P, I135R, S162SDGN, D177E, T200R, F214L, L228H, A288S, P294T, E297K	B
	CA17694	CA41631	AY802545	D4T, 3TC	None	M41L, A62V, D67G, M184V, L210W, T215Y, K219R	V108I	K20R, K43Q, E44D, K102S, V106I, T107A, V118I, K122E, Q174E, G196E, H208Y, R211K, K223Q, L228H, E297K, K350E	B
Villena (2007)	36708	36708-1	EF154391	D4T, 3TC, DDI	None	A62V, K70G, V75I, F77L, Y115F, F116Y, Q151M, M184V	Y181C	K20R, T39A, S68G, T69A, K101R, D123E, I135T, I167V, D177E, I202V, R211K, I293V, P294T, E297K, I375V, T386I, V435I, E449D, D460N, S468P, L491S, K512T, L517I, S519N	B
von Wyl (2007)	115	732708	EF449791	NRTI	None	A62V, M184V		V8I, V21I, K102KT, K122E, I135T, R211K	B
	2	697745	EF449969	NRTI	None	A62V, M184V		I135T, T200I	B
Rosen-Zvi (2008)	55	03p55-1		AZT, DDI, DDC	None	A62V, V75I, F77L, Q151M		K22N, I50S, V189I, R211K, F214L, T286A, I293V, E297A, E328D	B

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