<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype B
Gene RT
Mutation A62V
Rx >= 1 NRTI
(but no NNRTI)
IncludeMixtures No
References 31
Patients 76
Isolates 87
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Shafer (1995)JIDP26JIDP26W88AF021308AZT, DDINoneA62V, V75I, F77L, F116Y, Q151M, K219E T39A, S68G, A98S, I135V, R172K, Q174H, R211G, F214L, V245MB
Hammer (1997)ACTG320_26482648 AZT, DDI, DDC, D4T, 3TCNoneM41L, A62V, D67E, L210W, T215Y K43Q, I50IV, S68MV, W88C, V118I, K122E, S162SG, N175Y, R211K, A272P, K277R, I293IV, I329V, G333E, G359S, A371V, A376T, A400T, K451KR, D460N, Q487QHB
Winters (1998)J-AJ-AAF096882AZT, DDI, D4T, 3TCNoneM41L, A62V, T69A_SS, M184V, T215Y K20R, K43N, V118VI, K122KE, S162C, D177E, R211K, L228LHB
Albrecht (2000)ACTG303_1212RT_bl AZT, DDINoneA62V, V75I, F77L, F116Y, Q151M V35VI, S68SG, T69A, R83K, K173R, Q174K, V245E, A272P, I293V, E297A, E302EDB
  12RT_f1 AZT, DDI, 3TCNoneA62V, K65R, K70R, V75I, F77L, F116Y, Q151M, M184V T7P, V8G, V35VI, S68G, T69A, R83K, D123G, K173R, Q174K, V245E, A272P, I293V, L295T, E297AB
 ACTG303_13491349RT_f1 AZT, DDI, 3TCNoneA62V, V75I, F77L, Y115F, F116Y, Q151M, M184V, K219E V35I, S68G, D123E, S162T, V245M, K277R, Q278H, I293VB
Bacheler (2000)LB3-P25P25-0 NRTINoneA62V, V75I K20R, R83K, K103R, G196E, T200A, R211KB
Balotta (2000)CB-187CB-187AF252038D4T, 3TC, DDC, AZT, DDINoneM41L, A62V, L210W, T215Y T27TA, K43Q, E44D, K49R, V118I, K122E, E138A, S162C, Q174N, I178F, H208Y, R211K, L228HB
 CB-230CB-230AF252086DDC, AZT, D4T, 3TC, DDINoneA62V, M184V, L210W, T215Y R83K, D123E, R211KB
 CB-295CB-295AF252011AZT, D4T, 3TC, DDINoneM41L, A62V, L74V, M184V V35I, S48T, D123E, G196GDE, T200AB
 CB-1CB-1AF186766DDC, AZT, 3TC, D4TNoneA62V, V75I, F77L, F116Y, Q151M, M184V, K219Q W24WG, E40K, K43N, I50IF, E53D, S68G, T107TP, V118I, D121H, K122E, I178L, T200A, I202V, R211T, F214LB
Coakley (2000)EC34EC3480w D4T, DDINoneA62V, V75I, F77L, F116Y, Q151M K122E, I142D, R143W, A158S, I178M, R211G, A272P, T286A, I329VB
Shulman (2000)CA624CA9919AY802614DDI, D4T, 3TC, AZTNoneA62V, K70G, V75I, F77L, Y115F, F116Y, Q151M, M184V S68G, T69K, K122E, K166R, D177E, R211K, K277R, I293V, E297KB
Albrecht (2001)ACTG364_12081208 DDI, AZTNoneA62V, K70N, V75I, F77L, F116Y, Q151M E6D, T58N, S68G, D123E, I135T, S162C, D177E, I202V, Q207E, V245E, K277RB
 ACTG364_12121212 DDI, AZTNoneA62V, D67E, K70R, V75T, T215TI, K219Q K20R, T27S, I37L, S68G, V118I, K122E, E203D, F214L, L228H, A272P, Q278QE, T286AB
 ACTG364_33083308 AZT, DDI, 3TCNoneM41L, A62V, D67E, K70R, F116Y, M184MIV, L210W, T215Y V35I, T39TA, T69S, V90I, V118I, K122KE, S162C, E203EK, R211S, L228H, A272P, K277R, E300X, L301X, A304XB
 ACTG364_39073907 DDI, AZTNoneM41L, A62V, V75T, T215YL100LIV21I, I178IM, Q197QP, R211K, D218E, A272PB
 ACTG364_57105710 AZT, DDI, 3TCNoneA62V, D67E, K70R, T215F V35I, T69S, V118VI, I135T, K173N, G196E, A272P, K277R, Q278H, E297KB
Gonzales (2001)CA789CA1423AY030425AZT, DDC, D4T, 3TCNoneA62V, V75T, M184V I37L, K122E, D123N, P133PHLR, D177DE, I178IM, T200TA, E204ED, Q207DN, R211K, S268SR, I270IMB
 CA1388CA3636AY030542AZT, 3TC, DDI, D4TNoneA62V, V75T, M184V, L210LW V8I, D123E, I135V, S162C, R211K, V245MB
 CA1442CA3853AY030580D4T, 3TCNoneA62V, V75T, M184V D123E, I135IT, S162C, T200I, R211RKB
 CA1867CA4996AY030771D4T, 3TC, DDI, AZTNoneM41L, A62V, M184V, L210W, T215Y K43Q, V118I, I135V, I142IV, S162A, R211K, L228R, K238KRB
 CA2103CA7758AY030810AZT, DDI, DDC, D4T, 3TCNoneM41L, A62V, D67N, L74I, M184V, L210W, T215F, K219QK103NV35L, K64KR, K122E, K173E, I178L, V179VI, D218E, L228HB
 CA2321CA8419AY030865AZT, 3TC, D4TNoneA62V, M184V, T215CDGYV179DV35T, K103R, I135T, Q174E, R211K, K259KR, N265NT, A272SB
 CA3878CA9070AY030883DDI, D4T, 3TCNoneM41L, A62V, M184V, T215Y K43N, L109LI, K122E, S191SA, L193LF, T200I, I202IL, E203ED, R206R*, D218EB
 CA4418CA10627AY031272AZT, 3TC, ABCNoneA62V, M184V, T215Y I132IR, I135T, I142V, R211K, V245K, E248D, T286A, I293V, E297K, A304GB
 CA4461CA10930AY031305AZT, DDI, 3TCNoneM41L, A62V, M184V, L210W, T215Y T39A, E44D, A98S, D123E, I178L, E203K, Q207E, H208Y, R211K, I293V, M357T, E370D, T386I, A400L, K451R, D460N, R461K, V467I, L491S, E529DB
 CA5015CA12286AY031590DDC, D4T, AZT, 3TCNoneA62V, M184V, T215Y K20R, T69S, K122E, I142V, V245R, S251IB
 CA5278CA12941AY031835AZT, DDI, DDC, 3TCNoneA62V, Q151KM, M184V K20R, S68ST, F87FL, K122E, I135T, G155GR, I159IL, S162CW, F214LB
 CA5407CA13138AY031961AZT, 3TCNoneA62V, M184V K20KR, K43KR, K122E, I135RT, N137NS, R211K, F214L, L228R, E291D, E297RB
 CA5410CA13142AY031964AZT, DDC, 3TC, D4TNoneM41L, A62V, M184V, T215Y V35L, T39A, K122E, T139K, P140T, E169D, K173E, I178L, G196E, T200A, Q207E, A272P, K277R, I293VB
 CA6425CA15931AY032379DDC, D4T, 3TCNoneM41L, A62V, V75T, M184V K32N, D123E, I135R, V179I, T253TA, R284K, I293VB
 CA6825CA16887AY032557DDC, AZT, 3TC, D4TNoneA62V, K70R, M184V T69N, W88WC, K122E, D123E, I135IT, E169D, I202V, Q207N, R211K, F214FL, A272P, E297K, A299AGB
Katzenstein (2001)ACTG302_14441444RT_f1 DDI, AZT, 3TCNoneA62V, L74V, V75T, M184V I37L, V90I, I135M, S162A, Q197R, V245M, A288S, I293V, E297KB
 ACTG302_18931893RT_f1 AZT, DDI, 3TCNoneM41ML, A62V, D67E, K70R, F116Y, M184I, L210W, T215Y V35VI, T69S, R83RK, V90I, V118I, S162C, T165TI, R211S, L228H, A272P, K277R, R284RIB
 ACTG302_35883588RT_bl AZT, DDINoneA62V, K70R, T215F V35I, T69S, R83K, I135T, A158AS, K173N, G196E, A272P, K277R, E297K, E302DB
  3588RT_f1 AZT, DDI, 3TCNoneA62V, D67E, K70R, T215F K20KT, V35I, T69S, I135T, A158AS, K173N, G196E, A272P, K277R, Q278H, E297KB
Perez (2001)EP-2000EP-2000AF320524NRTINoneA62V, L210W, T215Y I63*, K64R, T69S, D121Y, K122E, A158S, S162D, F171L, R172E, K173N, Q174K, I178L, Q207E, R211KB
Servais (2001)JS21JS98025AJ401795AZT, DDI, D4T, 3TCNoneA62V, T69S_SS, K70R, M184I, L210W, T215Y K64R, D123E, Q197E, E203K, R211K, F214W, D218H, I244LB
  JS98158AJ401805AZT, DDI, D4T, 3TCNoneA62V, T69S_SS, K70R, M184I, L210W, T215Y K64R, V118I, D123E, Q197E, E203K, R211K, F214W, D218H, I244L, S251TB
  JS98287AJ401814AZT, DDI, D4T, 3TCNoneA62V, T69S_SS, K70R, M184I, L210W, T215Y K64R, V118I, D123E, Q197E, E203K, R211K, F214W, D218H, I244L, E248KB
  JS98465AJ401829AZT, DDI, D4T, 3TCNoneA62V, T69S_SS, K70R, M184I, L210W, T215Y L34F, S48L, K64R, V118I, D123E, I142T, Q197E, E203K, R211K, F214L, D218H, L228R, I244LB
Brindeiro (2002)TVSP19TVSP19AY145815AZT, 3TC, D4TNoneM41L, A62V, M184V, T215FA98GV106I, K122E, I135T, F214L, K249Q, A272P, K277R, E297A, V317AB
 TVGG19TVGG19AY145790AZT, 3TC, D4TNoneA62V, M184V M16V, K122E, D123N, I135T, D177E, T200E, I202V, R211K, V245M, A272P, V276I, I293VB
Clevenbergh (2002)CP0937CP0937AF519428NRTI, D4T, DDINoneA62V, D67E, T69S_SG, K70R, T215F V118VI, K122E, D123S, D177DE, Q207E, R211KB
 CP1902CP1902AF519424NRTI, D4T, 3TCNoneA62V, V75I, F77L, Y115F, F116Y, Q151MY181CT69N, K122E, K173Q, Q174R, I202V, Q207E, R211K, V245TB
Masquelier (2002)apv13apv13M4AY134468AZT, 3TCNoneA62V, D67G, M184V R83K, I135T, S162C, Q174H, D177E, G196E, Q197KB
Tural (2002)119733119733 AZT, DDC, 3TC, D4TNoneM41L, A62V, M184V, L210W, T215Y K20R, K43E, E44A, K166R, G196E, E203D, H208Y, K223Q, L228RB
 140180140180 AZT, DDC, 3TC, D4TNoneM41L, A62V, M184V, T215Y T69S, K122E, I135T, S162X, Q207E, L228HB
 880307880307 3TC, D4TNoneA62V, M184V K49R, D123E, I135T, E169D, Q197E, T200I, R211KB
 880807880807 DDC, AZT, 3TC, D4TNoneA62V, M184V, T215Y E29G, R83K, R211KB
 881217881217 AZT, DDI, 3TC, D4TNoneA62V, D67N, K70R, M184V, T215F, K219Q K20R, T39A, I135T, K166R, G196E, E204K, R211S, F214LB
 881302881302 DDC, AZT, 3TC, D4TNoneA62V, D67N, K70R, M184V, T215V, K219Q I50V, P119A, F124L, I135V, T200AB
Venturi (2002)GV-13GV-13.1AF517265AZT, 3TCNoneA62V, T69S_SS, M184V, L210W, T215Y D123E, K166R, R211KB
 GV-25GV-25.1AF517277D4T, 3TCNoneA62V, M184V I31L, R83K, V118VI, K122P, I132L, I135T, I142V, D177E, T200I, F214LB
Gonzales (2003)CA1157CA5071AF514025AZT, DDC, DDI, D4T, 3TCNoneM41L, A62V, D67N, T69D, M184V, L210W, T215Y, K219KR K20R, V35I, K43E, E44A, V118I, K122E, I135T, R211K, L228HB
 CA5462CA20101AF514227AZT, 3TCNoneA62V, M184V, L210LW, T215F E6D, K122E, I135T, E203EK, Q207E, R211K, R284K, I293V, E297AB
Gonzales (2003)CA6434CA15945AY032387AZT, 3TC, NRTI, D4T, DDINoneA62V, V75I, F77L, F116Y, Q151M K20R, K32E, V35I, K49R, I135V, S162CW, E169D, Q207E, R211K, A272P, I293VB
 CA7052CA17358AF514250AZT, D4T, DDINoneA62V, K65KR, V75I, F77L, Q151M A33V, V35T, S68G, K122E, D123N, I178L, T200A, H221HY, E248D, A272P, Q278QE, I293V, A299AG, A304GB
Shafer (2003)A384_40024002bEF548429AZT, 3TCNoneA62V, M184V S48T, K122Q, S162H, D177E, V179I, E194EG, G196E, Q207G, R211K, P243AB
Dumans (2004)197197AY390154AZT, DDI, D4T, 3TCNoneA62V, V75I, F77L, F116Y, Q151M, M184V, K219QE138KK49R, I50V, S68G, K101Q, R172K, V179A, I202V, F214LB
Kuritzkes (2004)KDR_pat190A0255AY528072AZT, 3TCNoneA62V, M184V D113DY, D123DEKN, K166R, R211RKB
Machado (2004)cs127cs127AY313377AZT, DDI, 3TCNoneA62V, M184V, T215Y S48T, K49R, K122E, D123E, I135T, I178MB
 cs157cs157AY313424AZT, DDINoneA62V, V75I, F77L, F116Y, Q151M K122E, I202V, F214LB
Montes (2004)MB_patMAR00_MAR712AJ577943AZT, DDI, D4T, 3TCNoneM41L, A62V, M184V, T215F D123E, D177E, I178L, R211K, F214LB
 MB_patAVO01_AVO720AJ577732DDC, AZT, 3TC, D4TNoneA62V, M184I, L210W, T215SA98GR83K, I135V, S162C, T165V, I202VB
Garcia-Bujalance (2005)GBS_31GBS_31AY872366DDC, AZT, 3TCNoneA62V, V75I, M184V E40ED, K43N, A98S, G196E, R211K, V245EB
Rhee (2005)CA789CA20223AY800704AZT, DDC, D4T, 3TCNoneM41L, A62V, V75T, M184V, T215Y I37L, S68G, K122E, D123N, I178M, T200A, E204D, Q207D, R211K, A288S, I293VB
 CA2197CA7970AY801140AZT, 3TC, D4TNoneA62V, T69S_SS, K70R, M184V Q85QH, A98S, D123E, D177E, G196R, Q207E, R211K, V245KB
 CA3878CA24613AY801182DDI, D4T, 3TCNoneM41L, A62V, M184V, T215Y K43N, L109I, K122E, T200I, D218E, Q278H, T286A, I293VB
  CA34810AY801183DDI, D4T, 3TCNoneM41L, A62V, M184V, T215Y K43N, L109I, K122E, T200I, D218E, Q278H, T286A, I293V, S322A, G359S, A371V, I375V, A376S, T386I, K390R, A400T, V435I, D460N, V467I, K476Q, L491S, E516Q, K558RB
 SWC-57295729-3376 AZT, 3TC, D4TNoneM41L, A62V, T69S_SS, M184I, L210W, T215Y V35M, K43E, V118I, K122E, I135T, V245QB
  5729-4183 AZT, 3TC, D4TNoneM41L, A62V, T69S_SS, M184I, L210W, T215Y V35M, K43E, V118I, K122E, I135T, V245QB
 CA5462CA13455AY801581AZT, 3TCNoneA62V, M184V, T215F E6D, K122E, I135L, Q207E, H208HY, R211K, R284K, I293V, E297AB
 CA6825CA48188AY801706DDC, AZT, 3TC, D4T, TDFNoneA62V, K70R, M184V, K219Q K49KR, T69N, K122E, D123E, I135T, E169D, T200A, Q207N, R211K, F214L, A272P, I293IV, E297KQB
 CA8050CA20184AY801930AZT, 3TC, D4T, DDINoneM41L, A62V, V75T, M184V, L210W, T215Y K122E, K173KR, V245E, K281R, I293VB
 CA9773CA23996AY802107AZT, DDI, D4T, 3TCNoneM41L, A62V, D67DN, V75T, M184V, T215Y I31IL, V90I, K102R, D123E, I142V, V179I, Q207N, T286A, I293V, E297K, E300E_E, I329L, A360T, A376T, T386I, A400V, D460N, V467I, L491S, S519N, A554T, I556V, V559IB
 CA9937CA24567AY802202AZT, 3TCNoneM41L, A62V, M184V, L210W, T215Y T7A, T39A, E44ED, R83K, D121H, K122E, K166R, D177E, I180IV, G196E, T200A, R211K, K277R, K281R, T286A, A288S, I293IV, E297KB
 CA9958CA38181AY802211AZT, 3TCNoneA62V, M184V K49R, I50V, R211T, T286AB
 CA14612CA35020AY802391AZT, 3TCNoneA62V, M184V, T215FY K49R, V90I, K122KE, D123DN, S162N, Q174R, R211K, R284K, I293VB
 CA16544CA39278AY802525D4T, 3TCNoneA62V, M184V K122P, I135R, S162SDGN, D177E, T200R, F214L, L228H, A288S, P294T, E297KB
 CA17694CA41631AY802545D4T, 3TCNoneM41L, A62V, D67G, M184V, L210W, T215Y, K219RV108IK20R, K43Q, E44D, K102S, V106I, T107A, V118I, K122E, Q174E, G196E, H208Y, R211K, K223Q, L228H, E297K, K350EB
Villena (2007)3670836708-1EF154391D4T, 3TC, DDINoneA62V, K70G, V75I, F77L, Y115F, F116Y, Q151M, M184VY181CK20R, T39A, S68G, T69A, K101R, D123E, I135T, I167V, D177E, I202V, R211K, I293V, P294T, E297K, I375V, T386I, V435I, E449D, D460N, S468P, L491S, K512T, L517I, S519NB
von Wyl (2007)115732708EF449791NRTINoneA62V, M184V V8I, V21I, K102KT, K122E, I135T, R211KB
 2697745EF449969NRTINoneA62V, M184V I135T, T200IB
Rosen-Zvi (2008)5503p55-1 AZT, DDI, DDCNoneA62V, V75I, F77L, Q151M K22N, I50S, V189I, R211K, F214L, T286A, I293V, E297A, E328DB
Steegen (2014)12ZAKS34012ZAKS340KJ176619D4T, 3TCNoneM41L, A62V, D67N, L74V, M184L, L210W, T215Y, N348IL100I, K103NP4PS, K20R, V35M, E44D, K102KR, T107S, L109I, I135T, S162C, V189I, Q197K, T200A, I202T, H208Y, R211K, H221Y, A272S, K277R, A288S, I293V, E297EK, E312EQ, S322A, Q334E, I341F, R356K, T386V, K390RB