<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype B
Gene RT
Mutation E44A
Rx >= 1 NRTI
(but no NNRTI)
IncludeMixtures No
References 16
Patients 30
Isolates 39
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Ruiz (1996)JCS-C43C43BZ99332AZT, DDINoneM41L, L210W, T215Y T39A, K43E, E44A, K49R, V118I, K122E, I135T, I142T, R143EB
Hammer (1997)ACTG320_27382738 DDC, AZTNoneM41L, L210W, T215Y V35M, K43E, E44A, K103R, V118VI, K122E, D123N, I135V, I178M, Q197K, T200A, H208HY, R211K, L228LH, A288AS, I341V, R358RK, A360AV, A371AV, A400AT, D460N, S468PB
Shafer (1998)HMDR-11-896-6BAF047283AZT, DDI, DDC, 3TC, D4TNoneM41L, D67N, M184V, L210W, T215Y K20R, V21I, V35I, K43E, E44A, K102Q, V118I, K122E, I135T, G196E, L205F, H208Y, R211K, E224D, A272P, I293VB
  1-1096AF047280AZT, DDI, DDC, 3TC, D4TNoneM41L, D67N, L210W, T215Y V35I, K43E, E44A, K102Q, V118I, K122E, I135T, G196E, L205F, H208Y, R211K, E224DB
  1-197AF047281AZT, DDI, DDC, 3TC, D4TNoneM41L, D67N, L210W, T215Y K20R, V21I, V35I, K43E, E44A, K102Q, V118I, K122E, I135T, G196E, L205F, H208Y, R211K, E224D, A272PB
 HMDR-22-896AF047292AZT, DDI, DDC, 3TC, D4TNoneM41L, D67N, T69D, M184V, L210W, T215Y K43E, E44A, V60I, K102Q, V118I, K122E, Q207E, R211KB
 HMDR-44AF047299AZT, DDC, DDI, D4T, 3TCNoneM41L, D67N, L74I, M184V, L210W, T215Y, K219NA98GK43E, E44A, K64R, R83K, V118I, Q161P, S163C, G196E, H208Y, R211K, D218EB
Zolopa (1999)CA634CA3138AF088100AZT, DDI, D4T, DDC, 3TCNoneM41L, D67N, T69D, M184V, L210W, T215Y K43E, E44A, W88C, V118I, I135V, I142V, K166KR, D177E, I178M, G196E, T200TA, E203D, H208Y, R211XB
Albrecht (2000)ACTG303_10571057RT_f1 AZT, DDI, 3TCNoneM41L, D67N, V75M, M184V, L210W, T215Y K43E, E44A, V118I, K122E, A158S, S162D, E169D, Q207QE, R211K, L264F, N265DB
 ACTG303_29772977RT_bl AZT, DDINoneM41L, T69D, L210W, T215Y, K219R K20R, V35I, K43E, E44A, A98S, V118I, E204K, R211D, L228H, A272P, T286AB
  2977RT_f1 AZT, DDI, 3TCNoneM41L, T69D, L210W, T215Y, K219R K20R, V35M, K43E, E44A, A98S, T107TP, V118I, E204K, R211D, L228H, A272P, T286AB
 ACTG303_47054705RT_bl AZT, DDINoneM41L, D67N, T69D, L210W, T215Y K11R, K20R, T39S, K43E, E44A, V118I, K122KE, E203D, H208HY, R211K, R284KB
  4705RT_f1 AZT, DDI, 3TCNoneM41L, D67N, T69D, M184V, L210W, T215Y K11KR, K20R, T39S, K43E, E44A, V118I, E203D, H208F, R211KB
 ACTG303_495495RT_bl AZT, DDINoneM41L, D67N, T69D, L210W, T215Y T39A, K43E, E44A, V118I, D123E, I142V, S162D, I178M, G196E, T200A, Q207E, R211K, V245T, D256DY, I293VB
Bacheler (2000)LB4-P102P102-0 AZT, 3TCNoneM41L, M184V, L210W, T215Y K43E, E44A, V118I, D123E, I142V, D177E, G196E, R211QB
Falloon (2000)JF07JF07-0wAF227717AZT, DDI, DDC, D4T, 3TCNoneM41L, D67N, T69D, M184V, L210W, T215Y T39A, K43E, E44A, V118I, K122KE, I135T, S162C, R211KB
  JF07-8wAF227718AZT, DDI, DDC, D4T, 3TC, ABCNoneM41L, D67N, T69AD, M184V, L210W, T215Y, K219KN T39A, K43E, E44A, V118I, K122KE, I135T, S162C, R211KB
Rousseau (2000)MNR5MNR4062AJ405950AZT, DDI, DDC, D4T, 3TCNoneM41L, D67N, T69D, L210W, T215Y K20R, K43E, E44A, V60I, K102R, V118I, K122E, D123S, E138A, Q197L, R211K, A272P, E297A, D324E, Q334E, A360T, I375V, A376S, K385R, K390R, A400T, E432G, G436EB
Albrecht (2001)ACTG364_19651965 AZT, DDINoneM41L, D67N, L210W, T215Y E28EA, K43E, E44A, K49R, V118I, D123E, I135T, K166T, E169D, Q174K, N175Y, G196E, Q207E, R211K, A272P, I293V, T296SB
 ACTG364_22632263 AZT, DDCNoneM41L, T69D, L210W, T215Y, K219R K43E, E44A, A98S, V118I, Q207D, R211K, L228R, V245E, I293VB
 ACTG364_34693469 AZT, DDI, 3TCNoneM41L, D67N, M184V, L210W, T215Y, K219N K43Q, E44A, V118I, A158S, E169ED, G196GE, Q207E, R211K, V245TB
Gonzales (2001)CA1157CA2632AY030466AZT, DDC, DDI, D4T, 3TCNoneM41L, A62AV, D67N, T69D, M184V, L210W, T215Y, K219KR K20R, V35I, K43E, E44A, V118I, K122E, I135T, H208HY, R211K, F214FL, L228H, A272P, K277RB
 CA2073CA7679AY030783DDC, AZT, DDI, D4T, 3TCNoneM41L, D67N, M184V, L210W, T215Y, K219N T27S, K43E, E44A, V118I, K122E, I142IV, A158S, I202V, R211K, N265NT, A272P, C280CRB
 CA3972CA9217AY030970AZT, 3TC, D4TNoneM41L, D67N, M184V, L210W, T215Y, K219NK101HK43E, E44A, K122E, I142V, S162C, E169D, H208Y, R211K, V245MB
 CA4729CA11591AY031391AZT, D4T, DDINoneM41L, D67N, L210W, T215Y V21I, T39TA, K43E, E44A, V118I, D123E, I142V, S162C, I178L, R211RK, E248ED, A272P, K277R, T286A, E297K, A304GB
 CA5102CA12385AY031670AZT, DDC, 3TC, D4TNoneM41L, D67N, M184V, L210W, T215Y, K219N K20R, V35X, K43E, E44A, A98S, V118I, K122KE, G196GE, H208Y, R211K, V245K, D250E, S251SCB
 CA6023CA14808AY032266AZT, DDI, DDC, D4T, 3TCNoneM41L, T69D, M184V, L210W, T215Y K20R, K43E, E44A, K49R, E53D, K102Q, V118I, K122E, D177E, I178M, E203K, H208Y, R211K, K223E, L228R, K277R, R284K, T286AB
Tural (2002)119733119733 AZT, DDC, 3TC, D4TNoneM41L, A62V, M184V, L210W, T215Y K20R, K43E, E44A, K166R, G196E, E203D, H208Y, K223Q, L228RB
Gonzales (2003)CA1157CA5071AF514025AZT, DDC, DDI, D4T, 3TCNoneM41L, A62V, D67N, T69D, M184V, L210W, T215Y, K219KR K20R, V35I, K43E, E44A, V118I, K122E, I135T, R211K, L228HB
Dumans (2004)240240AY390114AZT, DDI, 3TCNoneM41L, D67N, M184V, L210W, T215Y K43E, E44A, K104N, V118I, I142V, G196E, R211KB
 187187AY390123AZT, DDINoneM41L, D67N, L210W, T215Y K43E, E44A, K49R, K104N, V118I, K122E, D123N, D177E, I178M, V179I, T200I, R211KB
Mo (2005)89858985_d1 NRTINoneM41L, D67N, K70R, V75M, L210W, T215FY, K219HQK103N, V106A, F227LT39A, K43E, E44A, V60I, T69N, K102KR, V118I, K122E, I135V, I142V, D177N, I178M, G196E, E203EAKT, H208Y, D218E, V245KB
Rhee (2005)CA7101CA17443AY801771AZT, 3TCNoneM41L, M184V, L210W, T215Y K43E, E44A, K64KR, V118I, D121Y, K122E, I135T, S162C, I167M, G196GE, E203K, Q207E, R211K, L228H, A272P, T286A, A288AT, E297QB
  CA34591AY801772AZT, 3TCNoneM41L, M184V, L210W, T215Y K43E, E44A, V118I, D121Y, K122E, I135T, S162C, G196E, E203K, Q207E, H208HY, R211K, K223KQ, L228H, A272P, E297A, I329L, M357I, T369I, V435A, L469I, L491S, L517I, S519N, V531IB
  CA37747AY801773AZT, 3TCNoneM41L, M184V, L210W, T215Y K43E, E44A, V118I, D121Y, K122E, I135T, S162C, I167M, G196E, E203K, Q207E, H208Y, R211K, K223Q, L228HR, A272P, T286A, E297PB
 CA7119CA17469AY801790AZT, DDC, 3TCNoneM41L, D67N, M184V, L210W, T215Y, K219N K43E, E44A, V60I, V118I, D121Y, K122E, I135T, D177E, I178M, H208Y, R211K, K281KE, V292I, I293V, A299AGB
 CA7909CA19968AY801835DDC, D4T, 3TCNoneM41L, D67N, T69D, M184V, L210W, T215Y K20R, K43E, E44A, V60I, V118I, K122E, G196E, T200A, E203D, H208Y, R211D, T286A, I293VB
  CA34790AY801836DDC, D4T, 3TCNoneM41L, D67N, T69D, M184V, L210W, T215Y K20R, K43E, E44A, V60I, V118I, K122E, G196E, T200A, E203D, H208Y, R211D, T286A, I293VB
Rodrigues (2005)BR04511800AY441879D4T, DDI, ABC, AZT, 3TCNoneM41L, D67N, T69D, M184V, L210*W, T215Y, K219N E6D, T39N, K43E, E44A, A98AP, D110DN, V118I, K122E, I135T, V179I, T200TA, H208Y, R211K, K223Q, V245TB