Reverse Transcriptase Inhibitors

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Reverse Transcriptase Inhibitors

Subtype	B
Gene	RT
Mutation	E44A
Rx	>= 1 NRTI (but no NNRTI)
IncludeMixtures	No

References	16
Patients	30
Isolates	39

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	NRTIs	NNRTIs	NRTIDRMs	NNRTIDRMs	OtherMut	Subtype
Ruiz (1996)	JCS-C43	C43B	Z99332	AZT, DDI	None	M41L, L210W, T215Y		T39A, K43E, E44A, K49R, V118I, K122E, I135T, I142T, R143E	B
Hammer (1997)	ACTG320_2738	2738		DDC, AZT	None	M41L, L210W, T215Y		V35M, K43E, E44A, K103R, V118VI, K122E, D123N, I135V, I178M, Q197K, T200A, H208HY, R211K, L228LH, A288AS, I341V, R358RK, A360AV, A371AV, A400AT, D460N, S468P	B
Shafer (1998)	HMDR-1	1-896-6B	AF047283	AZT, DDI, DDC, 3TC, D4T	None	M41L, D67N, M184V, L210W, T215Y		K20R, V21I, V35I, K43E, E44A, K102Q, V118I, K122E, I135T, G196E, L205F, H208Y, R211K, E224D, A272P, I293V	B
		1-1096	AF047280	AZT, DDI, DDC, 3TC, D4T	None	M41L, D67N, L210W, T215Y		V35I, K43E, E44A, K102Q, V118I, K122E, I135T, G196E, L205F, H208Y, R211K, E224D	B
		1-197	AF047281	AZT, DDI, DDC, 3TC, D4T	None	M41L, D67N, L210W, T215Y		K20R, V21I, V35I, K43E, E44A, K102Q, V118I, K122E, I135T, G196E, L205F, H208Y, R211K, E224D, A272P	B
	HMDR-2	2-896	AF047292	AZT, DDI, DDC, 3TC, D4T	None	M41L, D67N, T69D, M184V, L210W, T215Y		K43E, E44A, V60I, K102Q, V118I, K122E, Q207E, R211K	B
	HMDR-4	4	AF047299	AZT, DDC, DDI, D4T, 3TC	None	M41L, D67N, L74I, M184V, L210W, T215Y, K219N	A98G	K43E, E44A, K64R, R83K, V118I, Q161P, S163C, G196E, H208Y, R211K, D218E	B
Zolopa (1999)	CA634	CA3138	AF088100	AZT, DDI, D4T, DDC, 3TC	None	M41L, D67N, T69D, M184V, L210W, T215Y		K43E, E44A, W88C, V118I, I135V, I142V, K166KR, D177E, I178M, G196E, T200TA, E203D, H208Y, R211X	B
Albrecht (2000)	ACTG303_1057	1057RT_f1		AZT, DDI, 3TC	None	M41L, D67N, V75M, M184V, L210W, T215Y		K43E, E44A, V118I, K122E, A158S, S162D, E169D, Q207QE, R211K, L264F, N265D	B
	ACTG303_2977	2977RT_bl		AZT, DDI	None	M41L, T69D, L210W, T215Y, K219R		K20R, V35I, K43E, E44A, A98S, V118I, E204K, R211D, L228H, A272P, T286A	B
		2977RT_f1		AZT, DDI, 3TC	None	M41L, T69D, L210W, T215Y, K219R		K20R, V35M, K43E, E44A, A98S, T107TP, V118I, E204K, R211D, L228H, A272P, T286A	B
	ACTG303_4705	4705RT_bl		AZT, DDI	None	M41L, D67N, T69D, L210W, T215Y		K11R, K20R, T39S, K43E, E44A, V118I, K122KE, E203D, H208HY, R211K, R284K	B
		4705RT_f1		AZT, DDI, 3TC	None	M41L, D67N, T69D, M184V, L210W, T215Y		K11KR, K20R, T39S, K43E, E44A, V118I, E203D, H208F, R211K	B
	ACTG303_495	495RT_bl		AZT, DDI	None	M41L, D67N, T69D, L210W, T215Y		T39A, K43E, E44A, V118I, D123E, I142V, S162D, I178M, G196E, T200A, Q207E, R211K, V245T, D256DY, I293V	B
Bacheler (2000)	LB4-P102	P102-0		AZT, 3TC	None	M41L, M184V, L210W, T215Y		K43E, E44A, V118I, D123E, I142V, D177E, G196E, R211Q	B
Falloon (2000)	JF07	JF07-0w	AF227717	AZT, DDI, DDC, D4T, 3TC	None	M41L, D67N, T69D, M184V, L210W, T215Y		T39A, K43E, E44A, V118I, K122KE, I135T, S162C, R211K	B
		JF07-8w	AF227718	AZT, DDI, DDC, D4T, 3TC, ABC	None	M41L, D67N, T69AD, M184V, L210W, T215Y, K219KN		T39A, K43E, E44A, V118I, K122KE, I135T, S162C, R211K	B
Rousseau (2000)	MNR5	MNR4062	AJ405950	AZT, DDI, DDC, D4T, 3TC	None	M41L, D67N, T69D, L210W, T215Y		K20R, K43E, E44A, V60I, K102R, V118I, K122E, D123S, E138A, Q197L, R211K, A272P, E297A, D324E, Q334E, A360T, I375V, A376S, K385R, K390R, A400T, E432G, G436E	B
Albrecht (2001)	ACTG364_1965	1965		AZT, DDI	None	M41L, D67N, L210W, T215Y		E28EA, K43E, E44A, K49R, V118I, D123E, I135T, K166T, E169D, Q174K, N175Y, G196E, Q207E, R211K, A272P, I293V, T296S	B
	ACTG364_2263	2263		AZT, DDC	None	M41L, T69D, L210W, T215Y, K219R		K43E, E44A, A98S, V118I, Q207D, R211K, L228R, V245E, I293V	B
	ACTG364_3469	3469		AZT, DDI, 3TC	None	M41L, D67N, M184V, L210W, T215Y, K219N		K43Q, E44A, V118I, A158S, E169ED, G196GE, Q207E, R211K, V245T	B
Gonzales (2001)	CA1157	CA2632	AY030466	AZT, DDC, DDI, D4T, 3TC	None	M41L, A62AV, D67N, T69D, M184V, L210W, T215Y, K219KR		K20R, V35I, K43E, E44A, V118I, K122E, I135T, H208HY, R211K, F214FL, L228H, A272P, K277R	B
	CA2073	CA7679	AY030783	DDC, AZT, DDI, D4T, 3TC	None	M41L, D67N, M184V, L210W, T215Y, K219N		T27S, K43E, E44A, V118I, K122E, I142IV, A158S, I202V, R211K, N265NT, A272P, C280CR	B
	CA3972	CA9217	AY030970	AZT, 3TC, D4T	None	M41L, D67N, M184V, L210W, T215Y, K219N	K101H	K43E, E44A, K122E, I142V, S162C, E169D, H208Y, R211K, V245M	B
	CA4729	CA11591	AY031391	AZT, D4T, DDI	None	M41L, D67N, L210W, T215Y		V21I, T39TA, K43E, E44A, V118I, D123E, I142V, S162C, I178L, R211RK, E248ED, A272P, K277R, T286A, E297K, A304G	B
	CA5102	CA12385	AY031670	AZT, DDC, 3TC, D4T	None	M41L, D67N, M184V, L210W, T215Y, K219N		K20R, V35X, K43E, E44A, A98S, V118I, K122KE, G196GE, H208Y, R211K, V245K, D250E, S251SC	B
	CA6023	CA14808	AY032266	AZT, DDI, DDC, D4T, 3TC	None	M41L, T69D, M184V, L210W, T215Y		K20R, K43E, E44A, K49R, E53D, K102Q, V118I, K122E, D177E, I178M, E203K, H208Y, R211K, K223E, L228R, K277R, R284K, T286A	B
Tural (2002)	119733	119733		AZT, DDC, 3TC, D4T	None	M41L, A62V, M184V, L210W, T215Y		K20R, K43E, E44A, K166R, G196E, E203D, H208Y, K223Q, L228R	B
Gonzales (2003)	CA1157	CA5071	AF514025	AZT, DDC, DDI, D4T, 3TC	None	M41L, A62V, D67N, T69D, M184V, L210W, T215Y, K219KR		K20R, V35I, K43E, E44A, V118I, K122E, I135T, R211K, L228H	B
Dumans (2004)	240	240	AY390114	AZT, DDI, 3TC	None	M41L, D67N, M184V, L210W, T215Y		K43E, E44A, K104N, V118I, I142V, G196E, R211K	B
	187	187	AY390123	AZT, DDI	None	M41L, D67N, L210W, T215Y		K43E, E44A, K49R, K104N, V118I, K122E, D123N, D177E, I178M, V179I, T200I, R211K	B
Mo (2005)	8985	8985_d1		NRTI	None	M41L, D67N, K70R, V75M, L210W, T215FY, K219HQ	K103N, V106A, F227L	T39A, K43E, E44A, V60I, T69N, K102KR, V118I, K122E, I135V, I142V, D177N, I178M, G196E, E203EAKT, H208Y, D218E, V245K	B
Rhee (2005)	CA7101	CA17443	AY801771	AZT, 3TC	None	M41L, M184V, L210W, T215Y		K43E, E44A, K64KR, V118I, D121Y, K122E, I135T, S162C, I167M, G196GE, E203K, Q207E, R211K, L228H, A272P, T286A, A288AT, E297Q	B
		CA34591	AY801772	AZT, 3TC	None	M41L, M184V, L210W, T215Y		K43E, E44A, V118I, D121Y, K122E, I135T, S162C, I167M, G196E, E203K, Q207E, H208HY, R211K, K223KQ, L228H, A272P, T286A, A288AT, E297LQ	B
		CA37747	AY801773	AZT, 3TC	None	M41L, M184V, L210W, T215Y		K43E, E44A, V118I, D121Y, K122E, I135T, S162C, I167M, G196E, E203K, Q207E, H208Y, R211K, K223Q, L228HR, A272P, T286A, E297P	B
	CA7119	CA17469	AY801790	AZT, DDC, 3TC	None	M41L, D67N, M184V, L210W, T215Y, K219N		K43E, E44A, V60I, V118I, D121Y, K122E, I135T, D177E, I178M, H208Y, R211K, K281KE, V292I, I293V, A299AG	B
	CA7909	CA19968	AY801835	DDC, D4T, 3TC	None	M41L, D67N, T69D, M184V, L210W, T215Y		K20R, K43E, E44A, V60I, V118I, K122E, G196E, T200A, E203D, H208Y, R211D, T286A, I293V	B
		CA34790	AY801836	DDC, D4T, 3TC	None	M41L, D67N, T69D, M184V, L210W, T215Y		K20R, K43E, E44A, V60I, V118I, K122E, G196E, T200A, E203D, H208Y, R211D, T286A, I293V	B
Rodrigues (2005)	BR045	11800	AY441879	D4T, DDI, ABC, AZT, 3TC	None	M41L, D67N, T69D, M184V, L210*W, T215Y, K219N		E6D, T39N, K43E, E44A, A98AP, D110DN, V118I, K122E, I135T, V179I, T200TA, H208Y, R211K, K223Q, V245T	B

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