Reverse Transcriptase Inhibitors

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Reverse Transcriptase Inhibitors

Subtype	B
Gene	RT
Mutation	N348I
Rx	>= 1 NRTI (but no NNRTI)
IncludeMixtures	No

References	9
Patients	21
Isolates	23

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	NRTIs	NNRTIs	NRTIDRMs	NNRTIDRMs	OtherMut	Subtype
Lin (1994)	PFL-013	PFL013B		AZT	None	M41L, T215Y, N348I		K11R, R83K, K166R, I202V, Q207E, A272P, I341L, K366R, I382L, K385R, K390R, A400T, N447S, V531I	B
		PFL013W78		AZT, D4T	None	M41L, D67N, L210W, T215Y, N348I		E6D, E44D, V118I, K166R, G196E, I202V, Q207E, A272P, I341F, R356K, A360T, I382L, K390R, A400T, N447S	B
Hammer (1997)	ACTG320_1812	1812		AZT	None	K70R, N348I		K20R, K64R, R83RK, V90VI, K122E, D123N, K166R, V245KQ, A272P, K277R, G359GS, A376N, D460N	B
	ACTG320_486	486		AZT	None	M41L, D67DN, L210W, T215Y, N348I		E44ED, W88C, V118I, R211K, V245KM, K277R, Q334L, K385KR, T386I, K390R, T403L, N447S, L452I	B
Bacheler (2001)	DMP004-100	04-100000B	AF349377	AZT, 3TC	None	M184V, N348I		V21I, R83K, R211K, E248N, T286A, Q334H, A376T, T386A, K390R	B
	DMP004-135	04-135000	AF349390	AZT, 3TC	None	K70R, M184V, N348I		E169D, K173Q, T200TA, F214L, V245M, D250E, A272P, K277R, I293V, G335D, T338S, G352GR, R356K, M357IT, A360AV, A376T, I393X, E396EG, T397TP	B
Gonzales (2001)	CA2097	CA7744	AY030804	AZT, 3TC	None	M41L, D67DN, K70R, M184V, N348I		S162A, Q174R, Q207E, A272P, I293V, K311R, S322T, Q334L, G335D, R356K, K366R, A400T, E404D, D460N, L469I, L491S, S519N, Q524E, V531I, K558R	B
	CA5242	CA12837	AY031799	AZT, 3TC, D4T, DDI	None	M184MV, N348I	V179D	V118I, K122E, I135T, I142IV, T200A, F214L, K277R, I293V, A299AG, I326T, R356K, T386I, K431KR, E432ED, R463RK, V466VA, T477TA, Q480QH, E492A, K527N, A554S, I556IV, K558KR	B
	CA6375	CA15868	AY032332	AZT, 3TC, D4T, DDI	None	M41L, D67N, L210W, T215Y, N348I		E6D, K43Q, E44ED, A98S, V118I, I135T, G196E, R211K, A272P, K277R, E291D, E297K, A304G, K311R, G359A, V365VI, K366R, I375IV, A376T, A400T, N418S, V435A, A437V, E449D, K451R, D460N, Q524E	B
Gibb (2002)	DMG100	100_w41		ABC, AZT	None	M184V, N348I		R83K, D123E, S162Y, G196E, R211G, A272P, I293V, E297Q, K311R, Q334L, I341V, E399D	B
Gonzales (2003)	CA5242	CA23663	AY305921	AZT, 3TC, D4T, DDI	None	F116Y, Q151M, N348I	V179D	V35IL, S68SG, T69TA, V118I, K122E, I135T, I142V, R172RK, T200A, F214L, K277R, I293IV, I326T, R356K, T386I, G436E, V466A, T477A, E492A, K527N, A554S	B
Rhee (2005)	CA7062	CA42582	AY801745	ABC, AZT, 3TC	None	D67N, K70R, M184V, T215I, K219E, N348I		V21I, A98S, R211K, V245E, A272P, K281R, E291D, I293V, E297N, N306D, Q334E, G335S, I341F, G359S, K366R, T369A, A371V, A376N, T377L, K390R, A400T, V435A, S468P, A554N	B
	CA7075	CA24140	AY801759	AZT, 3TC, ABC	None	Y115YF, M184V, N348I		M16MV, Q207E, R211K, V245E, A272P, I293V, T338S, K390R, T403I, Q428R, L452S, K512R, S519N	B
	CA7884	CA19929	AY801812	AZT, D4T, DDI	None	F77FL, Q151M, N348I		K22KR, R83RK, K166R, T200A, F214L, A272P, K277R, Q278QE, T286A, I293V, P294S, E297A, G333E, Q334H, I341F, K366R, A376AT, T386TI, A400T, T470A, H483Y, E516D, S519N, Q520N, K527N, K530R, A554S	B
	CA18408	CA42964	AY802561	AZT, 3TC	None	M184V, N348I		E40ED, I135IV, K173KE, V241VI, V245K, K277R, I293V, T386TI, K390R, E399EG, A400T, N447S, S519N, K527N, V548VI, A554S, V559I	B
Rhee (2009)	CA6888	CA16967	FJ983219	AZT, 3TC	None	M41L, M184V, T215F, N348I		I31V, A98S, D123E, S162C, E169ED, T200A, N265NY, A288S, D324E, M357V, A376T, A400T, T403R, V435A, V466A, S468P, Q480H, K512T, S519N, A554NSTY, I556V	B
	CA17662	CA41567	FJ983446	AZT, 3TC	None	M184V, N348I		V35T, V118I, K122V, V179I, T200A, Q207E, R211K, F214L, V245T, E248D, A272P, T286A, I326V	B
von Wyl (2010)	697949	697949	GQ848103	AZT, 3TC	None	M184V, N348I		S48T, K122P, D123A, D177E, T200I, Q207E, R211K, F214L, V245E, V276I, T286A, I293V, I341IV, R356K, A360AV, I375V, T377R, K390R	B
	1479657	1479657	GQ848109	AZT, 3TC	None	K70R, M184V, N348I		E6D, K64KR, T69S, I135V, K166R, T200I, R211K, F214L, V292I, I293V, D324E, G335S, K353R, R356K, G359GS, K366R, A376T	B
	1506769	1506769	GQ848110	ABC, AZT, 3TC	None	M41L, D67N, M184V, L210W, T215Y, N348I		K43E, E44ED, V60I, V118VI, D123E, D177DE, Q207E, R211K, K249Q, A272P, Q278HN, K281R, T286A, I293V, E297K, K311R, S322T, Q334L, M357T, G359GS, K385R, K390R, E399K	B
	4796137	4796137	GQ848125	AZT, 3TC	None	M184V, N348I		V35M, T39TA, K49KR, V60VI, R83K, K101R, D123DE, I135T, E169D, D250N, A272P, I293V, E297A, T338TS, P345Q, M357I, R358K, G359S, K366R, I375V, T386I	B
	4796717	4796717	GQ848130	AZT, 3TC, D4T	None	M184V, N348I		A98S, K101KQ, K102KQ, K122E, D123DN, E138A, I142V, S162C, R211RK, A272S, T286A, K311R, D324E, R358K, G359GS, T377R, K385R	B
	14439342	14439342	GQ848155	AZT, 3TC	None	M41L, D67N, M184V, L210W, T215Y, N348I		E28EK, K32KEQ, K43Q, E44D, V118I, D121HY, K122E, I135T, G196GE, T200I, E203K, Q207E, H208Y, R211K, L228H, A272P, A288AT, E297EK, I326IT, P345PQ, R356K, A360V, T377L, S379CG, K390KR	B

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