<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype B
Gene RT
Mutation N348I
Rx >= 1 NRTI
(but no NNRTI)
IncludeMixtures No
References 10
Patients 32
Isolates 35
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Lin (1994)PFL-013PFL013B AZTNoneM41L, T215Y, N348I K11R, R83K, K166R, I202V, Q207E, A272P, I341L, K366R, I382L, K385R, K390R, A400T, N447S, V531IB
  PFL013W78 AZT, D4TNoneM41L, D67N, L210W, T215Y, N348I E6D, E44D, V118I, K166R, G196E, I202V, Q207E, A272P, I341F, R356K, A360T, I382L, K390R, A400T, N447SB
Hammer (1997)ACTG320_18121812 AZTNoneK70R, N348I K20R, K64R, R83RK, V90VI, K122E, D123N, K166R, V245KQ, A272P, K277R, G359GS, A376N, D460NB
 ACTG320_486486 AZTNoneM41L, D67DN, L210W, T215Y, N348I E44ED, W88C, V118I, R211K, V245KM, K277R, Q334L, K385KR, T386I, K390R, T403L, N447S, L452IB
Bacheler (2001)DMP004-10004-100000BAF349377AZT, 3TCNoneM184V, N348I V21I, R83K, R211K, E248N, T286A, Q334H, A376T, T386A, K390R, A400TB
 DMP004-13504-135000AF349390AZT, 3TCNoneK70R, M184V, N348I E169D, K173Q, T200TA, F214L, V245M, D250E, A272P, K277R, I293V, G335D, T338S, G352GR, R356K, M357IT, A360AV, A376T, I393ILM, E396EG, T397TP, A400TB
Gonzales (2001)CA2097CA7744AY030804AZT, 3TCNoneM41L, D67DN, K70R, M184V, N348I S162A, Q174R, Q207E, A272P, I293V, K311R, S322T, Q334L, G335D, R356K, K366R, A400T, E404D, D460N, L469I, L491S, S519N, Q524E, V531I, K558RB
 CA5242CA12837AY031799AZT, 3TC, D4T, DDINoneM184MV, N348IV179DV118I, K122E, I135T, I142IV, T200A, F214L, K277R, I293V, A299AG, I326T, R356K, T386I, K431KR, E432ED, R463RK, V466VA, T477TA, Q480QH, E492A, K527N, A554S, I556IV, K558KRB
 CA6375CA15868AY032332AZT, 3TC, D4T, DDINoneM41L, D67N, L210W, T215Y, N348I E6D, K43Q, E44ED, A98S, V118I, I135T, G196E, R211K, A272P, K277R, E291D, E297K, A304G, K311R, G359A, V365VI, K366R, I375IV, A376T, A400T, N418S, V435A, A437V, E449D, K451R, D460N, Q524EB
Gibb (2002)DMG100100_w41 ABC, AZTNoneM184V, N348I R83K, D123E, S162Y, G196E, R211G, A272P, I293V, E297Q, K311R, Q334L, I341V, E399DB
Gonzales (2003)CA5242CA23663AY305921AZT, 3TC, D4T, DDINoneF116Y, Q151M, N348IV179DV35IL, S68SG, T69TA, V118I, K122E, I135T, I142V, R172RK, T200A, F214L, K277R, I293IV, I326T, R356K, T386I, G436E, V466A, T477A, E492A, K527N, A554SB
Rhee (2005)CA7062CA42582AY801745ABC, AZT, 3TCNoneD67N, K70R, M184V, T215I, K219E, N348I V21I, A98S, R211K, V245E, A272P, K281R, E291D, I293V, E297N, N306D, Q334E, G335S, I341F, G359S, K366R, T369A, A371V, A376N, T377L, K390R, A400T, V435A, S468P, A554NB
 CA7075CA24140AY801759AZT, 3TC, ABCNoneY115YF, M184V, N348I M16MV, Q207E, R211K, V245E, A272P, I293V, T338S, K390R, T403I, Q428R, L452S, K512R, S519NB
 CA7884CA19929AY801812AZT, D4T, DDINoneF77FL, Q151M, N348I K22KR, R83RK, K166R, T200A, F214L, A272P, K277R, Q278QE, T286A, I293V, P294S, E297A, G333E, Q334H, I341F, K366R, A376AT, T386TI, A400T, T470A, H483Y, E516D, S519N, Q520N, K527N, K530R, A554SB
 CA9807CA24090AY802127AZT, 3TC, ABCNoneD67N, K70R, M184V, T215FY, K219E, N348I K102Q, K122E, I135V, S162C, E204D, K277R, E297K, I326V, I329L, K385R, K390R, E399D, A400T, K431R, V435A, K454R, Q547R, V548I, A554NB
  CA34551AY802128AZT, 3TC, ABCNoneM41ML, D67N, K70R, M184V, T215FY, K219E, N348I T7TA, K102Q, K122E, I135V, S162C, K277R, R284K, E297K, I326V, I329L, K385R, K390R, E399D, A400T, K431R, V435A, K454R, Q547R, V548I, A554NB
 CA14205CA34336AY802269AZT, 3TC, D4TNoneM41ML, M184V, N348I K122P, I142IV, S162SN, L210F, R211K, K277R, E291D, A327V, I341IF, M357T, E370G, K390R, E404D, V435A, L452S, D460N, R461K, L469I, L491P, Q509H, S519N, Q524EB
 CA14249CA34414AY802283D4T, 3TCNoneM184MV, N348I R83K, I135IL, E138EA, I142IT, K166KR, T200TA, R211K, A272P, K277R, R284K, A288G, L289R, T290A, E291K, P294A, E297A, K311R, Q334L, M357T, I375V, T386V, A400T, D460NB
 CA14307CA34512AY802302AZT, 3TCNoneM41L, D67N, M184V, L210W, T215Y, K219Q, N348I K122E, I135R, E169D, I178L, H208Y, R211K, V245K, A272P, K277R, S322T, I326V, A371T, A400T, V435E, D460N, R461K, H483Y, S519N, K527NB
 CA14378CA34635AY802321AZT, 3TCNoneD67N, K70R, M184V, K219EQ, N348I E6ED, V60VI, A98AS, I135V, S162SC, N175Y, T200TA, R211K, I293V, E297R, L301I, R356K, A360V, T450S, S468P, S519N, K527R, A554TB
 CA16095CA38313AY802425AZT, 3TC, DDINoneM41L, D67N, K70R, V75M, F77L, M184V, L210W, T215Y, K219Q, N348I E44D, V60I, V118I, K122E, D123N, I135M, K166R, R211RK, D218E, L228H, K277R, V292I, I293V, E297A, A327T, I329M, Q330R, Q332L, Q334G, G335S, Q336QR, A360T, K366R, A371V, A376T, A400T, D460N, R461K, S468T, T470N, L491S, L517I, Q524E, A554S, K558RB
 CA16265CA38681AY802468AZT, 3TCNoneM184V, T215TNSY, N348I T39TA, R83K, D123E, I135IV, I142V, S162CY, G196E, E203K, E248D, D250DE, A272P, K277R, Q334E, G359S, A400S, E404D, V435A, D460N, R461K, S468T, L491S, Q547KB
 CA18408CA42964AY802561AZT, 3TCNoneM184V, N348I E40ED, I135IV, K173KE, V241VI, V245K, K277R, I293V, T386TI, K390R, E399EG, A400T, N447S, S519N, K527N, V548VI, A554S, V559IB
Rhee (2009)CA6888CA16967FJ983219AZT, 3TCNoneM41L, M184V, T215F, N348I I31V, A98S, D123E, S162C, E169ED, T200A, N265NY, A288S, D324E, M357V, A376T, A400T, T403R, V435A, V466A, S468P, Q480H, K512T, S519N, A554NSTY, I556VB
 CA7975CA23968FJ983252AZT, 3TCNoneM184V, N348I K32N, V35I, I135R, S162C, R211K, A272P, K277R, I293V, E300E_E, E312G, V317G, I329V, Q334E, M357T, K366R, A376S, T377S, E399D, A400T, E404D, V435A, D460N, R461K, S468T, H483YB
 CA14158CA34272FJ983344AZT, DDI, 3TCNoneD67N, K70R, M184V, K219Q, N348I V60I, K122E, I135IT, D218E, A272P, K277R, V292I, G359S, T377M, A400T, D460N, H483Y, K558RB
 CA14225CA34363FJ983352AZT, DDC, 3TC, D4TNoneM41L, D67G, T69D, L210W, T215Y, K219R, N348I E6D, V60VI, V118I, K122E, D123E, I135V, I142V, S162C, R211K, V245K, I293V, M357T, T369A, A400I, K451R, S468P, L469I, T470EKB
 CA17662CA41567FJ983446AZT, 3TCNoneM184V, N348I V35T, V118I, K122V, V179I, T200A, Q207E, R211K, F214L, V245T, E248D, A272P, T286A, I326VB
von Wyl (2010)697949697949GQ848103AZT, 3TCNoneM184V, N348I S48T, K122P, D123A, D177E, T200I, Q207E, R211K, F214L, V245E, V276I, T286A, I293V, I341IV, R356K, A360AV, I375V, T377R, K390R, A400TB
 14796571479657GQ848109AZT, 3TCNoneK70R, M184V, N348I E6D, K64KR, T69S, I135V, K166R, T200I, R211K, F214L, V292I, I293V, D324E, G335S, K353R, R356K, G359GS, K366R, A376TB
 15067691506769GQ848110ABC, AZT, 3TCNoneM41L, D67N, M184V, L210W, T215Y, N348I K43E, E44ED, V60I, V118VI, D123E, D177DE, Q207E, R211K, K249Q, A272P, Q278HN, K281R, T286A, I293V, E297K, K311R, S322T, Q334L, M357T, G359GS, K385R, K390R, E399K, A400TB
 47961374796137GQ848125AZT, 3TCNoneM184V, N348I V35M, T39TA, K49KR, V60VI, R83K, K101R, D123DE, I135T, E169D, D250N, A272P, I293V, E297A, T338TS, P345Q, M357I, R358K, G359S, K366R, I375V, T386IB
 47967174796717GQ848130AZT, 3TC, D4TNoneM184V, N348I A98S, K101KQ, K102KQ, K122E, D123DN, E138A, I142V, S162C, R211RK, A272S, T286A, K311R, D324E, R358K, G359GS, T377R, K385RB
 1443934214439342GQ848155AZT, 3TCNoneM41L, D67N, M184V, L210W, T215Y, N348I E28EK, K32KEQ, K43Q, E44D, V118I, D121HY, K122E, I135T, G196GE, T200I, E203K, Q207E, H208Y, R211K, L228H, A272P, A288AT, E297EK, I326IT, P345PQ, R356K, A360V, T377L, S379CG, K390KRB
Steegen (2014)12ZAKS34012ZAKS340KJ176619D4T, 3TCNoneM41L, A62V, D67N, L74V, M184L, L210W, T215Y, N348IL100I, K103NP4PS, K20R, V35M, E44D, K102KR, T107S, L109I, I135T, S162C, V189I, Q197K, T200A, I202T, H208Y, R211K, H221Y, A272S, K277R, A288S, I293V, E297EK, E312EQ, S322A, Q334E, I341F, R356K, T386V, K390RB