<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype B
Gene RT
Mutation G333E
Rx RTI-naive
IncludeMixtures No
References 58
Patients 434
Isolates 443
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Coakley (2000)EC7EC7B NoneNone  K122E, N175Y, I178M, G196E, T200A, Q207K, R211A, V245M, K249R, A272P, I293V, E297K, K311R, V317A, G333E, Q334L, R356K, K366R, A376S, T377M, K385R, S468P, K527R, V552VIB
 EC15EC15B NoneNone  Q207E, R211K, V245M, I293V, E312N, I326V, I329V, G333E, M357T, A376S, V381I, K390R, K395R, D460N, R461K, L491S, A554NT, K558RB
 EC24EC24B NoneNone  K22E, E28D, S162C, Q207E, R211K, P226S, V245M, I293V, E312N, I326V, I329V, G333E, M357T, A376S, V381I, K390R, D460N, R461K, V467I, L491S, A554T, K558RB
 EC26EC26B NoneNone V179DD123E, D177E, T200A, V245M, A272S, K277R, I293V, G333E, Q334Y, T338S, M357I, T377V, K390R, A400T, K512IB
Vergne (2000)LVMP1271LVMP1271AJ287044NoneNone  V35T, D123E, N175H, T200I, A272P, K281R, T286A, E297K, A327V, G333E, Q334H, M357T, A400T, V417AB
 LVMP701VICLVMP701VICAJ287046NoneNone  V60I, D123E, R211K, F214L, A272P, K281R, T286P, I293V, E297K, V317A, I326V, G333E, M357T, V365I, A400IB
 LV712GRILV712GRIAJ287048NoneNone  K11R, D123E, K166R, R211K, A272P, K277R, E291D, E297R, I329L, G333E, A376T, A400TB
 LV720ESTLV720ESTAJ287051NoneNone  V106I, K122E, E169G, K173E, R211K, F214L, A272P, K277R, T286P, I293V, E297K, K311R, G333E, Q334H, G335C, M357T, G359S, T369A, A371V, A376T, K390R, A400T, E404DB
Carr (2001)ARMA006ARMA006AY037278NoneNone  V35T, T39A, D123E, I142V, K166R, R211K, A272P, K277R, K281R, T286A, E297K, G333E, Q334H, K366R, A376T, T377L, K390R, E399D, A400T, K431T, V435A, E449D, D460N, R461K, T470N, H483L, E492K, S519N, A534S, V559IB
Gonzales (2001)CA3888CA9080AY030893NoneNone  D86E, I135V, I142V, G196E, Q197K, Q207E, A272P, I293V, E297V, G333E, Q334H, K347R, M357I, A376T, T386I, V435E, D460N, L491S, L517I, S519N, Q520K, K527N, A534TB
Gibb (2002)DMG5353_w-16 NoneNone  V35L, V60I, R83K, K103R, D123E, G196E, T200A, R211K, A272P, K281R, A288S, E297K, I329L, G333E, M357T, T369V, A376T, K390RB
Hierholzer (2002)US4US4AY173955NoneNone  D123E, G196E, Q207G, V245K, K277R, T286A, I293V, D324E, G333E, T377R, S379C, T386I, A400T, T403I, Y405H, L517I, A554SB
Maxeiner (2002)501229e501229epre NoneNone  R83K, K173N, Q174K, T200A, V245E, A272P, K277R, V292I, E297K, G333E, Q334H, V365I, A376T, K390R, V435VA, D460N, L491LS, A554N, K558RB
Podzamczer (2002)77BAA139033 NoneNone  A98S, D123E, I142IM, S162SC, K166KR, I178L, T200A, Q207E, R211K, F214FL, A272P, K277R, I293V, E297K, G333E, Q334L, M357T, A376S, K385R, K390RB
 45BAA139863 NoneNone  K49R, E53ED, V60VI, V90I, K122KE, I135IT, S162SDGN, K277R, L283LI, I293V, K311R, G333E, K390RB
 68BAA139869 NoneNone  I135V, D177G, T200A, Q207AEKT, R211RK, A272P, T286TA, T290TA, E297K, G333E, Q334L, G359S, T377TI, K390R, E396DB
Maljkovic (2003)MI_Pat2200SE20127AY165246NoneNone  D123E, I135T, I142V, S162A, D177E, I178L, R211RK, K277R, T286A, V292I, E297K, K311R, G333E, Q334HB
 MI_Pat2300SE20168AY165247NoneNone  K22KR, V35L, T39A, R83K, D123E, K173KN, D177E, I178L, I202IV, Q207R, R211K, F214L, A272P, T286A, E297T, K311R, G333E, Q334HB
 MI_Pat2598SE15517AY165199NoneNone  V35I, R83K, D123E, E169D, D177E, T200A, Q207H, R211K, A272P, K277R, T286A, I293L, E297A, G333E, Q334HB
 MI_Pat5901SE21621AY165259NoneNone  K20R, I135V, E169D, Q207E, R211K, I257IL, K277R, I293V, E297K, P313A, G333E, Q334LB
 MI_Pat6800SE20106AY165245NoneNone  K102Q, I135T, R211K, K281KR, L283I, I293V, P294Q, P313A, V317A, G333EB
 MI_Pat8001SE22070AY165268NoneNone  V35MR, T39X, V60VI, D121H, K122E, I132IV, I142T, D177EQ, I178X, V179VI, G196E, A272P, K277KR, T286A, V292VI, P294PT, E297K, K311R, G333EB
Pariente (2004)pt3131AY316008NoneNone  R83K, I135V, E138A, K166R, T200A, R211K, A272P, K277R, I293V, S322SL, G333E, R356K, A376V, S379C, K390R, E438E*, L452I, D460N, V467I, E516G, S519N, K527NB
 pt4242AY316025NoneNone  D123E, I135T, K173N, F214L, A272P, K277R, G333E, Q334H, K366R, T377Q, A400T, T403A, D460N, Q464E, L491SB
 pt4646AY316037NoneNone  D123E, I135T, I178IL, F214L, K277R, V292I, E297K, I329L, G333E, F346N, A376S, K390R, V435VAIT, D460N, L491S, E492Q, E529D, A534TB
 pt4848AY316043NoneNone  K49R, S68G, I135T, V241G, V254G, K277R, G333E, V435VI, S468SP, L491LSB
 pt7777AY316105NoneNone  V35I, R83K, K122E, I135T, I178IM, Q197E, Q207EGKR, R211KQ, A272P, T286A, V317A, I329L, G333E, Q334L, M357T, T403I, E404D, V435E, D460N, H483N, K512R, A554SB
Bernardin (2005)10121012-08AY331285NoneNone  R83K, K122P, I135V, I159V, D177E, V179I, R211K, A272P, I293V, I329V, G333E, G335C, A371V, A376T, K390R, V435A, K454R, K465R, V531I, A554NB
  1012-11AY331286NoneNone  R83K, K122P, I135V, I159V, D177E, V179I, R211K, A272P, I293V, I329V, G333E, G335C, A371V, A376T, K390R, V435A, K454R, K465R, V531I, A554NB
 10131013-03AY331287NoneNone  K20R, S162A, E248D, K281R, I293V, G333E, Q367L, K390R, E399D, A400T, V435M, V467I, A554T, I556VB
  1013-07AY331288NoneNone  K20R, K126KR, S162A, E248D, K281R, I293V, K311KR, G333E, Q367L, T369TI, K390R, E399D, A400T, V435M, V467VI, Q524QL, A554T, I556VB
 PRB959PRB959-03AY331296NoneNone  K122P, K173E, D177E, Q197H, Q207E, R211K, V245E, D250E, A272P, A288S, K311R, I329L, G333E, Q334Y, V365I, K390R, A400T, V435L, T470P, H483R, G490E, S519N, A554SB
  PRB959-05AY331297NoneNone  K122P, K173E, D177E, Q197H, Q207E, R211K, V245E, D250E, A272P, A288S, K311R, I329L, G333E, Q334Y, V365I, K390R, A400T, V435L, R463RG, T470P, H483R, G490E, S519N, A554SB
Ciccozzi (2005)MC_AY611666B10AY611666NoneNone  S48E, D123E, R211K, A272P, A288S, I293V, K311R, I329L, G333EB
Rhee (2005)CA16356CA38867AY802489NoneNone  A98S, K122KR, D123E, F171FL, K173T, Q174K, D177E, T200A, Q207HN, R211K, A272P, K277R, T286A, E297K, G333E, A376T, K390R, A400T, E404ED, N418S, V435I, N447NS, E449D, L452A, D460N, H483Y, S519N, V548IB
Sandstrom (2005)SP_SR02-CL-198402-CL-1984 NoneNone  R83K, K223R, K277R, T286A, E297K, G333EB
 SP_SR29-AL-198329-AL-1983 NoneNone  Q207E, A272P, K311KR, I326V, I329V, G333EB
Galkin (2006)04RU13909504RU139095AY819715NoneNone  V60I, I142V, Q197E, R211K, V245E, A272P, T286A, V292I, E297K, K311R, G333E, R356K, K366R, T369V, Q373H, A376T, T377M, A400T, V435T, L469F, T470N, L491V, S519N, A554SB
 139089139089AY751407NoneNone  K102R, I142F, S162C, S163T, K166R, I178M, V245E, A272P, T286A, E291Q, E297K, K311R, G333E, R356K, K366R, T369V, Q373H, A376T, T377M, A400T, V435T, L469F, T470N, L491A, V531I, A554SB
Lama (2006)Pt11861186 NoneNone K103NK20R, K122E, D123N, I135V, S162C, E204Q, R211RK, A272P, T286TA, I293V, I309F, L310*, D324E, G333EB
 Pt30033003 NoneNone  K11Q, D123DN, Q207K, V245I, T286A, I326V, I329L, G333E, Q334HB
 Pt30313031 NoneNone  M16Q, R83K, K102R, K103Q, D123E, S162H, V179I, T200I, R211K, K277R, I293V, E297K, K311R, G333E, Q334YB
 Pt30423042 NoneNone  K104R, K122E, D123S, I135T, I142T, Q174R, R211K, F214L, A272P, V292I, E297K, G333E, Q334AB
 Pt30603060 NoneNone  K20R, T27S, K32R, K102R, S162C, R211K, K238R, K277R, L283I, I293V, P294IT, E297K, I329L, G333E, Q334YB
 Pt31323132 NoneNone  I135T, S162C, V245VE, E248ED, K277R, T286A, E297K, I326V, G333E, Q334HB
 Pt32083208 NoneNone  S105A, I135V, K281R, T286A, E297K, I326V, G333E, Q334CB
 Pt32163216 NoneNone  V8I, V35VI, S68G, E79D, K104R, K122P, K173N, Q174K, I180IV, T200A, E203D, Q207HN, R211K, V245I, K275R, R284RK, T286A, I293V, I326V, G333E, Q334HB
 Pt32633263 NoneNone  V35I, K102R, V111I, K122E, D123N, K173R, Q174K, R211RS, F214L, T286A, A288S, P294PT, G333EB
 Pt32723272 NoneNone  E6D, V35VI, S162C, T200TA, E203D, V245N, T286A, I326V, G333E, Q334HB
 Pt33383338 NoneNone  T27S, D177E, I178M, A272P, K277R, T286A, I293V, P294T, E297K, I329L, G333EB
 Pt35363536 NoneNone  I135T, S162C, V189I, R211K, V245M, I293V, E312N, I326V, G333EB
 Pt35593559 NoneNone  K122E, D123G, I178L, A272P, T286A, I326V, G333E, Q334QHB
 Pt37503750 NoneNone  V21VI, D123E, I135T, D177E, T200I, F214L, A272P, K277KR, T286A, E297R, G333E, Q334NB
 Pt37593759 NoneNone  K20KR, S162C, R211K, V245VAMT, A272P, K277KR, V292I, I293V, E297V, I329L, G333EB
 Pt37723772 NoneNone  E28EG, D123E, K173E, I178M, T200A, R211K, V245VM, A272P, K275R, P294T, K311KR, I326V, I329L, G333E, Q334HB
 Pt40554055 NoneNone  V35M, K104R, K122E, I135RT, N137NH, K173R, Q174K, E194ED, G196E, T200A, R211K, F214L, A272P, V292I, I293V, P294T, G333E, Q334HB
 Pt42424242 NoneNone  T200E, E204D, V245VM, T286A, I326V, G333E, Q334HB
 Pt42484248 NoneNone  M16Q, R83K, K102R, K103Q, D123E, S162H, V179I, T200I, R211K, K277R, T286TA, I293V, E297K, K311R, G333E, Q334HB
 Pt45824582 NoneNone  K11KR, M16Q, V60VI, D121H, K122E, I178L, T200TIM, I202IV, A272P, K277R, T286TA, P294ST, E297R, V317A, G333E, Q334HB
 Pt46294629 NoneNone  I178M, E204D, R211K, V245T, T286A, I293V, I326V, I329L, G333E, Q334HB
 Pt51005100 NoneNone V179DV60I, K104KR, V118I, D121Y, K122E, I135T, K173N, T200AV, Q207E, R211K, F214L, V245E, T286TA, V292VI, P294T, E312H, G333EB
 Pt51175117 NoneNone  V35VI, I47IL, K49KR, E169ED, I178L, Q197QK, R211K, K277R, T286A, P294P*QS, E297K, I326V, G333E, Q334HB
 Pt52485248 NoneNone  K104R, I135V, I178M, T286A, V292I, E297K, I326V, G333E, Q334HB
 Pt52555255 NoneNone  V60I, R83K, I135T, K173E, R211K, V245I, A272P, K311R, I329L, G333E, Q334HB
 Pt52565256 NoneNone  D123E, I135IV, P176PS, T200A, V245VI, E248ED, A288S, E297K, I326IV, G333EB
 Pt56395639 NoneNone  I135T, D177E, R211K, T286A, I326V, I329L, G333EB
Margot (2006)94119411BL NoneNone  I135T, Q174H, R211RK, V245I, E248D, I293V, E297A, D324E, G333E, M357I, T386I, K390RB
 89268926BL NoneNone  R83K, D123E, Q197QE, R211K, T286AP, T296TS, E297RK, I329L, G333E, Q334H, A360AT, V365I, T369A, E370ED, V372VM, K374KR, K390KR, K395KR, E396DB
Petroni (2006)AP_ARRP025AP_ARRP025DQ206671NoneNone  S162C, G196V, T200A, E203D, R211K, V245E, I293V, I326T, G333E, Q334NB
 AP_ARRP039AP_ARRP039DQ345509NoneNone  V35L, P55A, V118I, D123E, I132V, S134C, T139R, D192N, R211K, F214L, V245E, A272P, K281R, T286P, I293V, E297R, G333E, Q334KB
Zarandia (2006)98GEMZ00698GEMZ006DQ207942NoneNone  E6D, D123E, I135T, Q207K, R211S, I244V, K277R, I293V, P294S, K311R, I329V, G333E, T386I, K390R, A400T, T403A, K431T, A508G, K527N, V559IB
Andresen (2007)PMVL 012PMVL 012EF514699NoneNone  V35VI, S68G, D121C, K122KE, I135T, S162C, I202V, Q207E, R211K, V245I, T286A, K311R, P321S, G333E, A376V, T386I, K390R, E399D, K431T, R461K, V466I, V467I, H483Y, Q509K, A554SB
Brumme (2007)1300PRRT_1300EF368610NoneNone  V106I, S162C, T200A, R211S, K277R, I293V, E297A, K311R, G333E, G359S, T377QB
 1303PRRT_1303EF368613NoneNone  I135V, S162C, R211K, A272P, K277R, T286A, I293V, I326V, G333E, K366R, T377MB
 1313PRRT_1313EF368623NoneNone  V35M, V60I, E138A, I142L, K166KR, K173N, D177E, I178M, A272P, K277R, I293V, G333E, T338S, R356K, K390RB
 1349PRRT_1349EF368659NoneNone  D86E, S162C, Q207E, K277R, I293V, E297A, I329L, G333E, R356K, E399DB
 1360PRRT_1360EF368670NoneNone  V35I, R83K, I135V, T139A, D177E, Q207H, R211K, V245M, A272P, T286A, K311R, G333E, T338S, M357A, A371V, A376T, K390R, E399DB
 1372PRRT_1372EF368682NoneNone Y188HV35I, I50V, V106I, K154KE, I178M, T200A, Q207E, L228F, A272S, V276I, I293V, E297K, I329V, G333E, T338S, K390RB
 1373PRRT_1373EF368683NoneNone  E6D, S162C, T200A, Q207QR, K277R, I293V, E297A, K311R, G333E, G359S, T377QB
 1383PRRT_1383EF368693NoneNone  T107S, D123E, I135V, P176PS, D177DEKN, G196GE, T200A, G333E, R356RK, K390R, K395RB
 1400PRRT_1400EF368710NoneNone  A98AT, R211K, K277R, T286TA, I293V, E297K, I329V, G333E, G335GS, A376S, K390RB
 1427PRRT_1427EF368737NoneNone  V35L, D177E, Q207E, R211K, D250E, A272P, K277R, P294T, G333E, T338S, Q367L, K374RB
 1465PRRT_1465EF368775NoneNone  I135T, I142V, Q174L, G196E, Q207H, R211K, V245M, A272P, I293V, K311R, V317A, G333E, Q334N, R356K, R358KB
 1480PRRT_1480EF368790NoneNone  E29EG, V35I, K102R, D177DN, Q207A, R211RK, V245K, A272G, T286A, I293V, G333E, T386P, K390R, E396DB
 1485PRRT_1485EF368795NoneNone  E53D, V106I, S162Y, I178IM, T200A, E203D, R211K, F214L, K277R, A288S, I293IV, E297K, I329L, G333E, A360T, T377V, K390RB
 1492PRRT_1492EF368802NoneNone  K101R, K102Q, D123E, I135T, S162C, D177DE, I195L, T200A, Q207E, R211RK, V245E, K277R, A288S, I293V, K311R, G333E, P345Q, A360T, D364E, E370D, T377R, T386I, K390RB
 1515PRRT_1515EF368825NoneNone  D123E, I135V, S162C, G196K, Q207EK, R211K, V276I, K277R, T286A, I326IV, G333E, G335N, K390RB
 1620PRRT_1620EF368930NoneNone  R83K, K122KE, G196K, T200TAEK, R211RK, V245EK, T286A, E297K, G333E, A360T, K366R, T369A, A376T, T377K, K390RB
 1634PRRT_1634EF368944NoneNone  K122KE, S162C, K173KE, I195IL, Q207E, R211K, E224D, A272P, K277R, L283I, I293V, K311R, G333E, Q334H, R356K, A360T, K390RB
 1664PRRT_1664EF368974NoneNone  V35VIL, D123E, K166KR, P176PS, T200A, R211K, A272P, K277KR, I293IV, E297A, I329L, G333E, M357T, T369A, A376T, K390RB
 1682PRRT_1682EF368992NoneNone  V35I, V60I, R83K, S162A, E169D, I202IV, Q207E, R211RK, A272P, K277R, T286A, I293V, V317VA, D324DE, G333E, Q334L, K366KR, K390R, E399DB
 1704PRRT_1704EF369014NoneNone  K102R, K122P, Q174K, N175NH, V179I, T200TA, I202V, Q207E, R211RK, E248D, A272S, T286A, I293V, E297KR, L301I, E312K, G333E, Q334A, E344ED, R356K, G359S, K385R, K390RB
 1706PRRT_1706EF369016NoneNone  K122P, S162C, I178M, Q207E, R211RK, A272P, K277R, E297K, P313Q, S322T, G333E, Q334L, G359S, V365I, T377M, K390R, E399DB
 1714PRRT_1714EF369024NoneNone  S68SN, I135T, T200A, R211K, A272P, K277R, T286A, E297K, G333E, R356K, A376S, K385R, K390RB
 1728PRRT_1728EF369038NoneNone  V35I, R83K, K122P, I135T, K166R, D177E, G196E, T200I, I202V, R211K, A272P, A288S, I329V, G333E, M357T, A376T, K395RB
 1741PRRT_1741EF369051NoneNone  K122E, D123DE, S162C, T200I, R211K, V245E, E248D, D250E, A272P, K277R, I293V, G333E, M357S, K390RB
 1754PRRT_1754EF369064NoneNone  A98S, D123DE, Q174H, D177E, T200E, R211RK, F214L, K277R, Q278H, T286A, I293IV, G333E, K390RB
 1761PRRT_1761EF369071NoneNone  E6D, R83K, D123E, S162A, R211S, V245K, A272P, K277R, I293V, E297K, L301I, G333E, M357I, K390RB
 1796PRRT_1796EF369106NoneNone  V8VI, K11KR, S162C, R211K, A272P, K277R, I293V, E297V, G333E, R358RK, G359GS, T377Q, A400ATB
 1817PRRT_1817EF369127NoneNone  K104KR, S162SN, T200TI, A272T, K277R, T286A, I293V, E297T, V317VA, G333E, Q334H, Q367L, T369S, K390R, E399DB
 1825PRRT_1825EF369135NoneNone Y188HV35I, I50V, T165I, I178M, T200A, Q207E, R211K, A272S, V276I, I293IV, E297K, I329V, G333E, T338S, K390RB
 1835PRRT_1835EF369145NoneNone  I142T, I195K, G196E, R211K, K277R, T286A, A288S, E297K, I329L, G333E, R356K, K366R, A376S, S379C, V381I, K390RB
 1866PRRT_1866EF369176NoneNone  I142T, S162C, R211K, K277R, I293V, P294ST, E297A, K311R, I329V, G333E, K390R, E399DB
 1881PRRT_1881EF369191NoneNone  E6D, K104KN, S162C, K173KR, Q174QR, Q207E, R211K, V245E, S251N, A272P, K277R, I293V, K311R, D324E, G333E, Q334L, M357VB
Dilernia (2007)F067F067EF120117NoneNone  V35M, R83K, K103R, D123E, T200A, R211K, D250X, A272P, K281R, V292I, I293V, E297K, D324DE, G333E, M357MT, K385R, K390RB
 F225F225EF120183NoneNone V179EK102R, D123E, I178M, T200A, R211RK, P243S, V245T, E248D, K249Q, D250X, A272P, V292I, I293V, I326V, I329L, G333E, Q334QH, T338S, R356K, T377M, S379SC, I380IV, K390RB
 F228F228EF120185NoneNone  K103R, K104R, I142V, T165V, K173Q, T200A, R211Q, F214L, D250X, K277R, I293V, P294Q, G333E, K390RB
 F268F268EF120202NoneNone  K20R, D123E, I135T, S162C, T200E, R211K, V245VA, D250X, V276VI, V292I, I293V, E297A, V317A, G333E, I375V, T386IB
 F302F302EF120219NoneNone  V35I, E36D, S48T, D123E, D177E, I202V, Q207N, R211K, E248D, D250X, A272P, Q278H, T286A, P294A, L310I, I326V, G333E, Q334L, T377K, T386I, K390RB
 F340F340EF120241NoneNone  R83K, D123E, Q207K, D250X, A272P, K281R, T286A, E291D, I293V, E297R, E298D, I329L, G333E, Q334L, A355AT, A376S, K385R, K390RB
 F358F358EF120247NoneNone  E6K, D123E, E138A, T139I, I142V, Q174H, Q197P, T200D, I202V, F214L, D250X, I257L, A272P, A288S, I293V, E297K, G333E, Q334G, T338S, M357T, A371V, A376S, S379G, T386IB
 F377F377EF120253NoneNone  D123E, I142IMT, Q197H, E248D, D250X, A272P, K281R, V292I, I293V, E297K, G333E, Y342F, A376V, K385R, K390RB
 N12N12EF120273NoneNone  D121Y, K122E, I135IT, S162C, I178L, T200E, R211K, V245VM, D250X, S251SI, A272P, K277R, I293V, K311R, I326V, G333E, Q334N, M357MT, T377M, K390RB
Holguin (2007)566361566361EF583180NoneNone  K22R, V35I, R83K, K166R, T200I, R211K, V245I, A272P, V276T, K277R, V292I, I329L, G333EB
 588503588503EF583201NoneNone  V35I, I135IT, K166R, I178M, G196E, E204Q, Q207D, R211K, A272AP, K277R, T286A, E297K, V317VA, G333E, Q334LB
 588779588779EF583205NoneNone  V60I, D123N, I142V, Q145E, K166KR, E169D, D177DE, I178IM, R211K, A272P, T286A, I293IV, G333EB
 592631592631EF583215NoneNone  K122KE, D123EK, T139K, I142V, S162A, T200A, R211K, A272S, A288S, I293V, P294T, K311R, I329L, G333EB
 602397602397EF583233NoneNone V179VDE6K, K122E, I142V, T165TI, T200I, Q207E, V245E, E248D, A272P, K277R, T286A, I293V, S322T, I329L, G333E, Q334HB
 609085609085EF583250NoneNone  V60I, K122E, I135T, K173N, D177E, Q207E, V245L, A272P, K277R, T286A, I329L, G333EB
Sanchez Onoro (2007)542035542035 NoneNone  K122KE, I135V, S162C, T200A, R211K, K277R, A288S, I293V, E297A, I329L, G333E, Q334HB
 565735565735 NoneNone  K49R, Y144D, K166R, E169D, I202V, R211K, F214L, V245L, A272P, K277R, T286A, I293V, G333E, Q334PB
 566361566361 NoneNone  K22R, V35I, R83K, K166R, T200I, R211K, V245I, A272P, V276T, K277R, V292I, I329L, G333EB
 588503588503 NoneNone  V35I, I135IT, K166R, I178M, G196E, E204Q, Q207D, R211K, A272AP, K277R, T286A, E297K, V317VA, G333E, Q334LB
 588779588779 NoneNone  V60I, D123N, I142V, Q145E, K166KR, E169D, D177DE, I178IM, R211K, A272P, T286A, I293IV, G333EB
 592631592631 NoneNone  K122KE, D123EK, T139K, I142V, S162A, T200A, R211K, A272S, A288S, I293V, P294T, K311R, I329L, G333EB
 602397602397 NoneNone V179VDE6K, K122E, I142V, T165TI, T200I, Q207E, V245E, E248D, A272P, K277R, T286A, I293V, S322T, I329L, G333E, Q334HB
 609085609085 NoneNone  V60I, K122E, I135T, K173N, D177E, Q207E, V245L, A272P, K277R, T286A, I329L, G333EB
 638296638296 NoneNone  V35M, K104R, D121Y, K122E, D123E, I135T, S162C, G196E, A272G, K277R, T286A, P294T, E297R, I329L, G333EB
 668850668850 NoneNone  K20KR, K122E, D123K, T139K, I142V, S162AT, T200A, R211K, A272S, K277KR, A288S, I293V, P294T, K311R, I329L, G333EB
 715042715042 NoneNone  V35I, K49R, K104R, D121DY, K122E, D123EG, I135T, S162C, G196E, R211K, A272G, T286A, P294T, E297R, I329L, G333EB
 722213722213 NoneNone  K11Q, V35I, T39K, R83K, K122E, D123N, I135T, K166R, T200I, Q207K, V245M, A272P, T286A, K311R, D324E, G333E, Q334HB
 730675730675 NoneNone  V8I, V35VL, R83K, K173R, R211K, K249Q, S251SN, T286A, A288S, V292I, I293V, E297R, G333EB
Bang (2008)046BJH_046EF157902NoneNone V179DS68G, K122E, I135T, L149P, Q174K, G196Q, T200I, Q207H, R211K, V245E, I293V, P313K, S322T, I329L, G333E, Q334LB
 074BJH_074EF157930NoneNone  K122E, P176S, D177V, I180L, T200I, Q207E, A272P, I293V, E312V, D324E, I329V, G333EB
Holguin (2008)SP37-328369SP37-328369EU255410NoneNone  D123E, S162C, Q207K, R211S, A272P, K277KR, I326V, G333E, Q334NB
 SP54-291099SP54-291099EU255427NoneNone  T200A, R211K, V245Q, D250E, K277R, V292VI, I293V, E297A, I329V, G333EB
 SP58-336356SP58-336356EU255431NoneNone  V21I, V35T, D86E, V90I, D123E, Q174H, D177E, Q197P, I202V, A272P, I293IV, E297K, E300X, L301I, G333E, Q334LB
 SP62-341508SP62-341508EU255435NoneNone  V60I, R83K, D123E, K166R, D177E, I202V, R211K, V245IM, A272P, I293V, E297V, A327AV, I329V, G333EB
 SP113-336733SP113-336733EU255459NoneNone  V35I, R83K, D123E, I135T, Q197P, R211K, I244V, A272P, K277KR, K281R, E297K, I326M, G333EB
 SP124-327038SP124-327038EU255469NoneNone  T165I, Q174LPS, T200I, I202V, V245E, A272P, K277R, T286A, I293V, E297A, G333EB
 SP13-345365SP13-345365EU255498NoneNone  V35I, R83K, K122KE, I135T, E169X, T200I, I202IV, Q207E, V245K, A272P, A288S, I293V, G333EB
 SP14-349418SP14-349418EU255499NoneNone  K49R, K122E, I135L, N175H, I180V, Q197P, R211K, A272P, T286A, I293V, E297K, G333E, Q334LB
 SP19-349515SP19-349515EU255504NoneNone  D123E, I135T, D177E, I178M, G196E, Q197E, T200A, Q207K, R211M, F214L, A272P, K277R, L283I, I293V, E297R, G333EB
 SP74-368266SP74-368266EU255559NoneNone  A272P, K277R, I293V, E297A, P313T, G333E, Q334HB
 SP82-376146SP82-376146EU255567NoneNone  K49R, K122E, S162C, R211K, A272P, K277R, T286A, I326V, G333EB
 SP21-0152794SP21-0152794EU342762NoneNone  V35I, D123E, I135M, S162ADG, I178M, T200A, I202V, E204D, R211RK, A272P, K281R, V292I, E297R, H315Y, G333E, Q334QHB
 SP29-0275182SP29-0275182EU342765NoneNone  K11R, K20R, V60I, D123E, I135T, I178M, R211RG, A272P, V276I, K277R, T286A, P294S, E297R, L301I, G333EB
Ibe (2008)117117AB428551NoneNone  E6D, V35I, S68G, I135T, T139I, G196E, R211G, V245E, A272P, T286A, P294Q, K311R, G333E, Q334L, E344D, A371V, T377K, K390R, T403M, G436E, D460N, V467I, H483Y, L491S, L517V, K558RB
 194194AB428553NoneNone  V60I, S68G, G196E, R211G, V245E, A272P, K281R, T286A, I293V, P294Q, K311R, G333E, Q334L, A371V, T377K, T403M, Y405H, D460N, V467I, L491S, L517V, K558RB
 197197AB428554NoneNone  V60I, S68G, G196E, R211G, V245E, A272P, K281R, T286A, I293V, P294Q, K311R, G333E, Q334L, A371V, T377K, T403M, Y405H, D460S, V467I, L491S, L517V, K558RB
 227227AB428555NoneNone  E6D, S68G, K102R, K122E, I135T, I142L, V179I, G196E, T200TI, I202IV, R211G, V245E, A272P, T286V, P294Q, G333E, Q334M, G359S, A371V, T377K, K390R, T403M, N447S, D460N, V467I, L491S, L517VB
 426426AB428556NoneNone V179DE6D, S68G, V106I, D123E, K166KR, G196E, R211G, F214L, V245E, A272P, K281R, T286A, I293V, P294Q, K311R, E312AV, G333E, Q334L, K366R, A371V, T377K, K390R, T403M, D460N, V467I, T470N, L491S, L517VB
 436436AB428557NoneNone  E6D, V35I, S68G, K82KR, T139L, G196E, T200I, R211G, V245E, A272P, T286A, I293V, P294Q, I309V, K311R, S322SA, G333E, Q334L, Y342F, M357V, A371V, I375V, T377K, K390R, T403M, G436E, D460N, V467I, H483Y, L491S, L517V, K558RB
Miura (2008)BEC5BEC5EU517974NoneNone  I135T, G333E, Q334P, R356K, S379G, N418S, Q509H, L517I, V548IB
 BEC117BEC117EU517977NoneNone  E6D, K20R, K166R, D177E, Q207E, R211K, A272P, I293V, E297K, K311R, G333E, P345T, A360T, T377M, S379C, T386I, A400T, T403A, D460N, R461K, V467I, T470A, L491V, I506L, S519NB
 BEC78BEC78EU518002NoneNone  P97PS, K122KR, V179VI, G196E, Q207E, V245K, V292I, I293V, I309IL, G333E, T377R, S379C, T386I, K388R, E396D, Y405H, V435VA, L452I, R461K, L517LV, A554T, V559IB
 BEC119BEC119EU518010NoneNone  R83K, G196E, K277R, Q278H, T286A, A288G, E297K, I309IT, K311R, G333E, Q334H, T338S, D364E, T377K, V417I, D460N, R463RK, K465R, V467I, S519NB
 BEC112BEC112EU518007NoneNone  K64R, I142V, I159V, K166R, Q174H, D250E, S251C, A272P, K277R, Q278H, T286A, I293V, G333E, Q334L, M357T, V365I, K366KR, T369A, A376T, A400T, V435I, K465R, K512R, A554T, K558RB
Riddler (2008)3557751320EaHM056540NoneNone  K20R, V60I, K102KR, K122E, D123A, D177DE, I178IM, T200A, R211K, P294Q, I326V, G333E, Q334A, T403M, S468P, K476R, H483Y, L517I, S519N, V531IB
 RG41688RG41688w0 NoneNone  E6D, K20R, V60I, R83K, D123E, T200I, R211RK, A272P, K281R, T286A, E297K, K311R, D324E, G333E, Q334N, A360V, Q373N, K390RB
 53793580603GaHM056630NoneNone  V35M, T39A, I135IV, S162C, E169D, Q174H, G196E, T200I, I202V, A272P, K277R, I293V, G333E, Q334H, G335S, R356K, M357K, K390R, D460N, R461K, L491S, S519N, Q547KB
 6845461503BaHM056609NoneNone  D123E, V245M, A272P, K277R, I293V, I326IV, I329V, G333E, Q334H, A360T, T377L, T403M, F416Y, L452LS, K465R, L517I, S519N, K527NB
 RG71350RG71350w0 NoneNone  A98AP, D123DE, E169EK, K173E, R211Q, F214L, A272P, K277R, T286A, I293V, E297K, G333E, T338S, M357MIT, K366R, T377L, K390KRB
 58373776D_bsHM056603NoneNone  K20KR, W88C, D123E, I135T, S156P, K173R, I178IV, R211K, W212WR, F214L, V245E, A272P, T286A, E297EA, G333E, Q334L, G359S, T377L, V381I, T386I, K390R, Q394L, E396D, A400T, P412PL, A445AV, E449D, T470A, K512R, K558RB
 62520817F_bsHM056625NoneNone  K103R, D123E, I135T, R211K, A272S, K277R, P313T, V317G, G333E, K385R, K390R, E404D, R463K, H483Q, A554NB
Aghokeng (2009)CYV75CYV75GU191551NoneNone  K20R, V35T, E36A, T39K, K43E, K122E, D123N, I142V, S162A, K173S, Q174K, D177E, V179VI, T200A, Q207A, R211K, F214L, V245Q, K281R, T286A, E291D, V292I, I293V, P294T, E312D, I326V, G333E, G335D, M357K, G359S, K366R, T369V, A371V, I375V, A376V, A400T, T403M, W410YB
Brennan (2009)A27ARC-A27EU711432NoneNone  V35M, T39A, Q174QK, I178M, R211K, P243H, V245Q, A272P, K277R, I293V, G333EB
 A12ARC-A12EU711440NoneNone  E28EK, V35I, S48T, D123E, S162C, D177E, E194D, T200I, Q207A, R211E, E248D, A272P, I293V, K311R, G333E, Q334HLB
 A2ARC-A2EU711449NoneNone  V35L, R83K, G196E, R211K, V245M, D250S, T286A, E297K, S322T, G333E, Q334HB
 A9ARC-A9EU711450NoneNone  K49KR, I135T, S162SN, K166R, D177EK, I178M, V245M, A272P, E291D, K311KR, I329L, G333EB
 A44ARC-A44EU711454NoneNone  V35I, R83RK, K122KE, A158AS, S162SN, K166R, D177E, I178M, V241I, D250E, A272S, K277R, V292I, I293V, D324E, G333E, Q334HB
Brumme (2009)A0526A0526GQ371764NoneNone  V60I, R83K, K104KN, E138A, S162C, I178L, Q207QE, R211K, F214L, S251I, A272P, K277R, T286A, A288AS, V292VI, I293V, T296TS, E297K, K311KR, I329L, G333E, R356K, K390R, A400T, V435I, E449D, D460N, H483Y, A554NB
 A1519A1519GQ371766NoneNone  V35VL, D123E, V189I, Q207E, N255NH, K277R, T286V, I293V, E297K, G333E, Q334H, G359S, K390R, T403M, V467I, S468P, T470S, H483Y, L503I, S519N, V531I, A554SB
 A1541A1541GQ371767NoneNone  V35I, I50V, D123E, D177E, I178M, T200K, E204Q, R211K, D250E, A272P, K277R, L283I, I293V, E297R, G333E, A355T, K385R, K390R, A400T, D460N, H483Y, L517I, S519N, A554N, K558RB
 A2508A2508GQ371768NoneNoneK70KN K49R, E79EK, S162C, Q174H, V179VG, T200A, E204X, Q207E, R211K, T286A, K311R, P313Q, D324E, G333E, Q334R, G335E, G359S, T377M, T386I, T403R, N447NS, T450NS, L452I, L491S, S519N, V531IB
 A2520A2520GQ371769NoneNone  I135V, K166R, V179I, K277R, A288S, I293V, E297A, G333E, K350K*, K366R, A376T, T377Q, K390KR, A400T, V435I, D460N, H483Y, L517V, S519N, Q524EB
 A5511A5511GQ371778NoneNone  S162C, G196E, Q207E, A272G, I293V, E297R, L301I, D324DE, I329L, G333E, M357V, K385R, K390R, K395R, E399D, A400T, V435A, E449D, T470TN, H483HY, Q487L, L517I, A534AS, A554N, K558RB
 A6513A6513GQ371779NoneNone  K20R, V21I, V35VL, K122E, D123N, S162A, T165I, E169D, D177E, I178M, T200I, F214L, A272P, K277R, E298EK, G333E, Q334H, M357A, K390R, A400I, T403TS, T450S, D460N, V467I, H483Y, L491S, Q520QKB
 B1501B1501GQ371790NoneNone  I5IV, D121H, K122E, I135T, V245VA, A272P, K281R, L283I, I293V, E312V, G333E, Q334N, G335S, T386I, K390R, A400T, N418S, V435I, A446S, R461K, V467I, S468T, H483N, L517I, S519N, A554AT, K558RB
 B1539B1539GQ371792NoneNone  Q23X, V35I, S48T, E53D, I142T, S162Y, Q174H, R211K, A272P, K281R, T286A, A288T, E297K, E312A, G333E, Q334H, M357T, T369S, A376S, A400T, E404D, A437V, D460S, R461K, S468T, H483Y, L491S, K512Q, L517I, S519N, A554SB
 B4578B4578GQ371799NoneNone  V8I, V21VF, I135T, R211K, F214L, V245E, D250X, T286A, E297K, D324E, I329L, G333E, R356K, V365I, E396D, A400T, V435E, D460N, R461K, V467VI, H483Y, I526IV, A554ADNTB
 D4506D4506GQ371821NoneNone  S162F, K173E, Q207A, R211K, P243T, A272P, K277R, E291EG, E297A, L301M, G333E, Q334N, K390R, A400T, A446S, L452I, V467I, S468P, T470N, H483Y, S519NB
 F0511F0511GQ371861NoneNone  V35I, R83K, D121Y, K122E, I135T, T165I, T200I, R211K, T286A, I329L, G333E, K390R, A400T, E404D, K451R, D460N, S468T, L469I, T470A, K512R, S519N, A554S, K558RB
 G0522G0522GQ371885NoneNone  E6G, V35I, E36EK, R83K, I135V, K166R, T200A, R211K, V245M, A272P, K277R, E297R, L301I, E312V, G333E, R356K, M357T, K366R, T377I, K395R, A400T, V435A, D460N, R461K, L491S, L517I, V548VI, A554AD, V559IB
 H9514H9514GQ371929NoneNone  R83K, K104R, D123E, K166R, V245A, A272P, I293V, E297V, V317A, G333E, P345Q, K366R, V381I, T386I, K390R, A400L, L517I, V518I, A554SB
 L3516L3516GQ371984NoneNone  E6K, V35L, S48T, K122E, D123E, G196E, T200I, R211G, A272P, T286P, I293V, E297K, V317A, G333E, M357T, A376T, K390R, A400T, E404D, V435A, D460N, R461K, S468T, Q480H, L491S, E492EK, I506IF, K512Q, E516Q, S519N, K527R, V531I, A554NB
 L4571L4571GQ371990NoneNone  E36EK, K122KE, T200A, Q207N, R211K, V245E, A272P, K277R, E297K, L310I, G333E, Q334L, G359S, T377L, T386I, K390R, A400T, T403TI, E432ED, V435IM, D460N, S519N, E529EKB
 L8503L8503GQ371995NoneNone  V35I, N81ND, R83K, Q174H, I178IM, T200A, R211K, Y271F, K277R, Q278QH, T286A, E291D, I293V, I329L, G333E, Q334HY, I375V, T377L, T386I, K390R, A400T, A437V, E449D, D460S, L469I, T470P, Q480H, L491S, Q524E, A554ASTB
 L8537L8537GQ371996NoneNone  K32R, R78RS, P170PL, T200A, R211K, V245M, A272P, K277R, I293IV, E297K, D324E, I329L, G333E, R356K, T369A, K385R, A400T, T403V, E404D, K451R, S468P, K476K*, H483N, E516EV, A554S, K558KRB
 M2511M2511GQ372005NoneNone  K20R, D123E, K126KQ, I135T, P176S, G196E, R211RK, V245VM, D250DE, A272P, G333E, Q334Y, I341V, K347R, A360T, T386I, K390R, T403M, V435I, V467VI, H483Y, I495L, S519N, Q520L, V548VI, A554SB
 M4526M4526GQ372008NoneNone  K22R, R83K, T200A, R211K, V245E, A272P, V276I, E297K, D324P, I329L, G333E, Q334H, R356K, A400T, V435A, T450S, K451R, D460N, V466A, L491S, S519NB
 M9531M9531GQ372022NoneNone  K20R, V35I, W88C, K122P, E169D, I178L, R211K, F214L, A272P, K277R, L283I, K287R, I293V, I329L, G333E, Q334H, M357T, T369A, K374R, I375V, A400T, E404D, V435E, S468ST, K476R, H483Q, Q524K, K527Q, K530R, A534T, A554S, V559IB
 O0542O0542GQ372050NoneNone V106VMV35M, D121H, K122E, I135IT, S162C, D177E, T200A, R211K, V245VE, K277R, K281KR, T286A, A288S, E297K, G333E, M357ST, A376T, K390R, E399D, A400T, V435M, F440FY, K454R, R463K, T470V, H483Y, K512R, Q524E, V531VF, R557RKB
 O9545O9545GQ372073NoneNone  A98S, R211K, T286A, E297K, I329L, G333E, I375V, T377M, A400T, V435E, A437V, L452S, D460S, R463K, S468P, T477A, H483QB
 Q4546Q4546GQ372111NoneNone  K20R, V35VI, V90VI, Q145QE, R211RK, K277R, I293V, S322T, I329IV, G333E, M357V, I375IV, K390KR, K454KQ, R461K, H483HYB
 Q5528Q5528GQ372112NoneNone  D123E, D177E, R211K, V245M, A272P, K277R, I293V, H315HR, L325LV, I326V, I329V, G333E, Q334H, A360T, Q367QH, T377L, T403M, F416Y, R448RT, V458VA, K465R, L517I, S519N, K527NB
 Q8571Q8571GQ372118NoneNone  R83K, G196E, Q207KN, A272P, E297R, K311R, I326V, G333E, A376T, T377L, T386I, K390R, E399D, A400T, D460N, L491A, A554ASB
 R8512R8512GQ372139NoneNone  I142T, T200E, Q207E, E248D, T286A, K311KR, V317VA, S322T, G333E, Q334H, T377I, K390R, T403L, K451KR, L469I, H483Y, S519N, K527N, A554SB
 R9535R9535GQ372144NoneNone  V35I, D123E, D177E, T200A, L210S, R211K, A272P, K281R, P294T, E297R, I329L, G333E, M357T, A376T, A400T, K431T, N447S, A534T, A554T, K558RB
 T2534T2534GQ372179NoneNone  V35I, R83K, I178L, Q207E, Q242X, T286A, V292I, E297A, K311R, D324E, G333E, K390R, A400T, T403A, V435I, V458VI, R461RK, V466A, V467I, S468SP, H483Y, G490E, L517I, Q524E, K530KR, K540KRB
 T4513T4513GQ372181NoneNone  K20R, T165I, N175H, T200A, F214L, A272P, K277R, T286A, E297K, G333E, T338S, R356K, T369V, A376T, T377L, K390R, A400T, Y405H, A408AT, V435I, N447NS, A554SB
 T7528T7528GQ372190NoneNone  V35T, F171Y, I178M, G196E, Q207E, V245E, A272P, K277R, T286A, I293V, E297R, G333E, Q334H, R356K, A360T, S379G, D460NB
 W6520W6520GQ372237NoneNone  V35IM, T139A, I142T, Q174H, I202V, Q207E, R211K, F214L, V245K, I270IF, A272P, I293V, P294PS, E297A, D324E, I329L, G333E, Q334G, I375IV, V381VI, K390R, A400T, E413D, P420PL, R463K, H483Y, I495IV, Q507X, S519N, Q524E, V531IB
 X5533X5533GQ372257NoneNone  K13KN, K103R, D123E, I135T, R211K, A272S, K277R, P313T, V317G, G333E, K385R, K390R, E404D, R463K, H483Q, A554NB
 Y4518Y4518GQ372283NoneNone  V35VI, D177NS, I178M, A272P, K275R, Q278N, S322T, G333E, Q334H, M357T, K390R, A400T, T403S, E413ED, V435I, K451KR, S519N, V531I, A554TB
 Y4542Y4542GQ372285NoneNone K101KEK20R, W88C, D123E, I135T, K173R, I178V, R211K, F214L, V245E, A272P, T286A, E297EA, G333E, Q334L, G359S, T377L, V381I, T386I, K390R, Q394L, E396D, A400T, E449D, T470A, K512R, K558RB
 Y5526Y5526GQ372286NoneNone  I142T, G196E, T200I, Q207R, H208HY, V245I, K277R, A288S, V292VI, I293IV, K311KR, V317VA, I326V, I329V, G333E, M357I, R358RK, T369TA, A371AT, K390KR, E449D, S468P, H483N, L517I, Q547QR, K558RB
 Y5575Y5575GQ372287NoneNone  K22KR, S48T, K122P, K173E, D177E, I178IV, V189VI, T286A, G333E, Q334H, G335S, R356K, M357K, E370D, K390R, T403M, V467I, S468P, V559VIB
 Z3571Z3571GQ372303NoneNone  I2IFV, V60I, R83K, K104R, D121Y, K122E, S162C, I178L, G196E, T200A, A272P, K277R, T286A, I293V, E297K, G333E, Q334N, G335S, L349LP, K350R, H361HP, K366R, K390R, A400T, V435I, D460N, L491SB
 Z4573Z4573GQ372307NoneNone  T39IK, G93GE, K101R, S162C, R211K, A272P, I329L, G333E, F346C, A376S, T377TILP, T386TI, K390R, A400T, V435A, D460N, R461K, V467I, S519NB
 Z5514Z5514GQ372308NoneNone  K20R, K104R, A158S, R211G, V245K, A272S, K277R, I293V, G333E, Q334N, G335S, M357MV, T377M, T386I, K390R, T403IM, V435I, A455AV, H483C, E516K, K527N, A554TB
 PRRT_4078PRRT_4078GQ303767NoneNone  D123E, I135T, D177E, Q197E, T200E, Q207R, K277R, K281KR, T286A, A288S, I293V, E297K, G333E, M357MT, D364E, K390R, E396ED, K431KR, D460N, R461K, Q480H, H483Y, K527N, A554T, K558RB
 PRRT_4114PRRT_4114GQ303803NoneNone  K11KR, K20KR, K122E, Q174H, T200TI, A272P, K277R, T286P, I293V, E297R, G333E, Q334L, K390R, V466VI, S468P, L469LI, H483Y, A502AV, L517LIB
 PRRT_4118PRRT_4118GQ303807NoneNone  R83K, E169D, G196K, Q207EK, R211KQ, K249KR, A272P, K277R, I293V, E297K, K311KR, E312EA, V317VA, I329L, G333E, Q334QH, R356RK, T369A, A376T, K390R, A400T, V417I, V435VI, L452A, D460N, S468F, T470N, H483HN, L517LI, S519SNB
 PRRT_4145PRRT_4145GQ303834NoneNone  I142V, S162A, K277R, L283I, A288S, V292I, I293V, G333E, G335S, R356K, T386TI, K390R, K431KR, V435VA, V467I, S468P, L484LI, A554S, V559VIB
 PRRT_4146PRRT_4146GQ303835NoneNone  T200A, Q207QE, A272P, K277R, V292VI, E297A, I329IV, G333E, Q334QH, R356RK, A360AT, T369TS, K390R, V435A, D460N, R461K, S468T, H483HQ, S519N, A554S, K558RB
Kousiappa (2009)CY142CY142EU673396NoneNone  V35I, V106I, D123E, E169K, K173E, I178L, G196E, R211S, F214L, K277R, I293V, E297K, G333EB
Nadai (2009)162387162387EU839596NoneNone  S48T, V60I, K64R, D121C, K122E, S162C, Q174QH, I178L, G196E, T200A, Q207E, V245T, D250E, A272S, K277R, T286A, I293V, G333E, Q334L, A360T, T369A, T377R, S379C, K390R, T403M, E404D, E432D, K512Q, L517I, S519N, A554T, K558RB
Vercauteren (2009)pt219132399760GQ398833NoneNone  S162C, Q207E, R211K, I244V, V245K, A272P, K281IR, T286A, V292I, K311R, S322A, D324E, G333EB
 pt2169224452139GQ398855NoneNone  K49R, V60I, K122KQ, D123DE, I135T, K166KR, K173R, D177E, Q207E, R211K, V276VI, K277KR, A288S, V292I, I293V, E297K, E312V, I329V, G333EB
 pt2099737615731GQ398925NoneNone  D123E, I135T, S162C, D177E, Q207H, R211K, V245VE, K277R, I293V, D324E, I329V, G333E, Q334RB
 pt20421033424985GQ398982NoneNone  V35I, R83K, K122E, I135T, F214L, E291ED, I293V, E297KR, I329V, G333EB
 pt20361089109740GQ398988NoneNone  K20KR, V35M, K122E, S162T, R211K, A272P, A288S, E297K, G333EB
 pt18622086655563GQ399162NoneNone  K30Q, K32G, A33C, L34T, V35L, E36N, I37F, E53D, D123E, I135T, T200A, Q207D, R211K, A272P, I293V, E297K, G333EB
 pt17093123619815GQ399315NoneNone  S3R, K49R, S162C, Q174L, D177E, Q207G, R211K, V245I, A272P, K277R, I293V, E297K, D324E, G333E, Q334HB
 pt16733294568068GQ399351NoneNone  V35I, R83K, D121H, K122E, D177E, I178V, R211K, A272P, E291D, E297K, I329L, G333EB
 pt15983754046391GQ399426NoneNone  K101R, S162C, Q207E, R211K, I244V, V245K, A272P, T286A, V292I, K311R, S322A, D324E, G333EB
 pt15653947926666GQ399459NoneNone  E28A, V35T, T39M, V60I, A98S, K122E, D123S, I135T, T200I, Q207R, R211G, F214L, V245VE, A272P, K277R, T286A, E291D, V292I, I293V, E297T, V317A, G333E, Q334LB
 pt15593984695540GQ399465NoneNone  S162C, T200TA, Q207E, R211K, V245EK, A272P, K281R, T286A, K311R, S322A, D324E, G333EB
 pt15264107984746GQ399498NoneNone  V35I, K101R, D123E, I135V, I142V, S162C, D177E, R211K, K277R, A288S, I293V, G333EB
 pt14584530893045GQ399566NoneNone  D123E, I135T, S162C, D177E, V179A, Q207H, R211K, K277R, I293V, D324E, I329V, G333E, Q334LB
 pt14494561763567GQ399575NoneNone  E53ED, K122KE, D123E, D177E, R211K, A272P, K277R, I293V, P294T, E297K, V314VI, I329L, G333E, Q334CHRYB
 pt14244714215376GQ399600NoneNoneV75VL K122E, I135K, T139TS, I178IM, G196E, R211K, V245Q, A272P, V292I, I293V, P294A, E297K, G333EB
 pt13435151577759GQ399681NoneNone  V60I, K122P, I142T, S162C, D177E, I178L, T200K, R211K, V245Q, E248D, A272T, K277R, A288S, I293V, E297A, G333E, Q334HB
 pt12325803214341GQ399792NoneNone  D121H, K122E, S162C, T200A, Q207E, R211K, K249Q, S251I, I293V, G333EB
 pt11856062230452GQ399839NoneNone  E6K, K122E, I142T, I202V, R211K, A272P, K277R, I293V, I326V, G333EB
 pt11736141741059GQ399851NoneNone  M16MV, K20R, V35I, E79ED, A98AS, K101KR, K102Q, V106VI, V118I, K122KE, I135T, K166R, G196GE, R211K, F214L, A272P, K281R, E291D, I293V, P294A, E297R, G333EB
 pt11636200514972GQ399861NoneNone  D123E, I135IT, S162C, D177E, Q207H, R211K, K277R, I293V, D324E, I329V, G333E, Q334LRB
 pt11576246480820GQ399867NoneNone K103NV35I, A98S, K122E, D123S, I135T, D177E, Q207H, R211K, A272P, K277R, V292I, I293V, E297K, K311R, G333E, Q334QLB
 pt10516943936421GQ399973NoneNone  E28A, V35T, T39M, V60I, A98S, K122E, D123S, I135T, T200TI, Q207K, R211G, F214L, V245E, A272P, K277KR, T286A, E291D, V292I, I293V, E297T, V317VA, G333E, Q334LB
 pt10476951397760GQ399977NoneNone  S162C, Q207E, R211K, I244V, V245K, A272P, K277R, T286A, V292I, I293V, K311R, S322A, D324E, G333EB
 pt8927897989264GQ400132NoneNone  K11R, T139A, I178M, T200V, V245M, A272P, K277R, P294T, V317T, I329L, G333E, Q334HB
 pt8807925278584GQ400144NoneNone  V35I, R83K, K122R, D123E, D177E, T200A, Q207H, R211K, A272P, K277R, E297V, G333E, Q334HB
 pt8588004756646GQ400166NoneNone  K22KN, V35T, T39A, E53D, V60I, D123E, S163ST, K166KR, K173KN, D177DN, G196E, Q207D, R211K, V245M, A272P, K277KR, I293V, E297K, G333EB
 pt8558039756639GQ400169NoneNone  A98S, Q207T, R211K, K277R, I329V, G333EB
 pt8128315538933GQ400212NoneNone  K126R, S162C, R211K, A272P, K277R, V292I, E297K, I326V, I329L, G333EB
 pt7838478988114GQ400241NoneNone  D123E, I135T, S162C, D177E, Q207H, R211K, K277R, I293V, D324E, I329V, G333EB
 pt7678551253869GQ400257NoneNone  K32Q, V35I, R83K, D123E, I135RT, E169D, D177E, Q207H, R211K, A272P, K277R, T286A, E297A, G333E, Q334HB
 pt7628585751680GQ400262NoneNone  V35IM, K122KE, G196E, E204Q, Q207D, R211K, V245Q, A272P, K281KR, V292I, E297K, G333E, Q334LB
 pt7608593734577GQ400264NoneNone  K122P, A158S, K166R, D177E, T200I, R211Q, K277R, T286A, G333EB
 pt5889473074207GQ400436NoneNone  A158S, K166R, D177E, I178M, L193F, I195L, Q207R, R211Q, A272P, T286A, I293V, G333E, Q334LB
 pt5859481387484GQ400439NoneNone  P4S, K20R, V35I, K43R, V60I, K101R, I135V, K173N, R211K, V245M, A272P, T286A, P294S, I326V, G333EB
 pt5729526613047GQ400452NoneNone  S68G, D123E, S162A, D177E, I178V, R211K, V245E, K277R, T286A, A288S, I293V, E297K, G333EB
 pt4999945338591GQ400525NoneNone  S162C, R199RI, Q207E, R211K, I244V, V245K, A272P, T286A, V292I, K311R, S322A, D324E, G333EB
 pt4839zffrgotbMGQ400541NoneNone  R83K, D123E, I135T, S162Y, D177E, R211K, K277R, T286A, A288S, E297T, G333EB
 pt372h5Xl14VNiAGQ400652NoneNone  K104KR, D177E, T200AE, T286TA, A288S, I293V, E297K, I329V, G333EB
 pt362hSpq6jLKX6GQ400662NoneNone  K103KR, D123E, T139A, F214L, A272P, K277R, Q278H, T286A, G333EB
 pt96v1F68yu3qNGQ400928NoneNone  V35I, R83K, K166R, Q207E, R211K, A272P, T286A, E298G, I329L, G333EB
 pt16z7ygMCceTZGQ401008NoneNone  K20R, V35I, E40EK, S68G, K102KR, D123E, D177E, I178L, V179I, G196E, T200I, E204K, R211G, F214L, A272P, K277R, G333EB
Wang (2009)1229I1229IFJ469685NoneNone  T69S, R83K, K166R, D177E, F214L, V245M, A272P, K281R, I293V, E297K, G333E, G335S, R356K, G359S, A371V, A376V, T386I, A400T, D460N, S519NB
 CR0068PCR0068PFJ469695NoneNone  K20R, T69S, I135T, G196E, F214L, V245I, E248D, K277R, I293V, P294Q, G333E, M357T, A360V, T386V, A400T, D460N, R463K, H483L, K512R, L517V, K527NB
 CR0078CR0078FJ469696NoneNone  V35I, K122E, D123S, I135V, V245K, K277R, Q278E, I293V, G333E, Q334R, K390R, R461K, V466I, L469I, T470P, L491S, L517I, V548IB
 CR0080NCR0080NFJ469697NoneNone  I135T, T200E, R211Q, Q278N, I293V, V317A, I326V, I329V, G333E, Q334N, K385R, K390R, T403M, T470P, L517IB
 CR0116YCR0116YFJ469698NoneNone  V60I, S68G, R83K, V90I, K166R, G196E, T200I, R211K, A272P, K277R, T286A, E297R, I326V, G333E, Q334H, P345Q, K390R, A400T, D460N, T470A, L491S, S519N, K527R, A554SB
 CR0295SCR0295SFJ469716NoneNone  K122E, D177E, I178M, G196E, E204K, Q207E, F214L, V245Q, I293V, G333E, Q334L, M357T, V365I, T377R, T386I, V435G, K454R, H483Y, K527NB
 CR0382NCR0382NFJ469725NoneNone V108IS48T, I50I_F, K64R, K122P, D123E, T139R, Q174E, D177E, G196E, A288S, E297K, I329L, G333E, Q334H, M357V, V365I, K390R, A400T, I434L, A437V, V458I, L491S, S519N, E529D, V531IB
 F762PF762PFJ469735NoneNone  S162C, T200A, Q207A, R211K, K277R, I293V, P294Q, K311R, G333E, T377I, K390R, A400T, S468P, E516K, K558RB
 L805L805FJ469738NoneNone  S162C, D177E, R211K, A272P, I293V, G333E, Q334L, T338S, K390R, A400T, N447S, L452S, Q547H, V548IB
 NCQNCQFJ469752NoneNone  S68G, K122E, I135V, S162C, I178L, T200A, Q207N, R211K, V245M, A272P, K275R, E297K, E312Q, I329V, G333E, G335C, M357T, A371V, S379G, T386I, T403M, R461K, V466I, V467I, H483Y, Q524E, V531IB
 PRLS01PRLS01FJ469753NoneNone  E44K, D110N, D123E, D177E, I178M, G196E, R211K, A272P, T286A, I293V, E297K, I326V, G333E, Q334Y, M357T, K390R, E432D, L452A, L469I, H483Y, L491S, A554TB
Bonura (2010)912_RI912_RIGU969477NoneNone  D123E, S162C, A272P, T286A, V292I, I293V, S322T, G333EB
 799_10799_10GU969521NoneNone  V35VI, K49R, I50IV, R83K, I135T, T200A, R211K, A272PS, V276IT, K277KR, E297K, V317AG, I329L, G333E, Q334HB
 1190_821190_82GU969546NoneNone  K20KR, K102KR, K122P, K166R, D177E, V179I, R211K, V245VM, A272P, K277KR, I329L, G333EB
 1229_1261229_126GU969565NoneNone  D123E, S162C, R211RK, F214FL, A272P, T286TA, E297K, P313PT, G333EB
 888_52888_52GU969578NoneNone  D123E, S162C, R211RK, A272P, T286A, V292I, I293V, E297EA, E298EA, S322T, G333EB
Brennan (2010)Pat164ARC-A62JN697215NoneNone  S162C, E169D, R211K, A272P, I274V, K277R, Q278N, A288S, I329L, G333E, Q334YB
 Pat125ARC-A105JN697254NoneNone  K11KR, E53ED, K64KR, K66KR, K122KE, D123DN, I142T, G196E, T200A, A272P, V292VI, I293IV, E297K, D324E, G333E, Q334NB
 Pat116ARC-A115JN697263NoneNone  S68G, I135T, T200V, V245EQ, D250DE, A272AP, K277R, T286V, E291D, G333E, Q334HB
 Pat105ARC-A126JN697274NoneNone  K20R, K104R, D177E, I178M, V245M, A272P, V292I, K311R, G333E, Q334NB
 Pat104ARC-A129JN697275NoneNone  K20R, D123E, S162C, F171Y, K173KR, Q174KR, R211K, I244V, D250E, A272P, V292I, I293V, E297EK, G333E, Q334HB
 Pat103ARC-N25JN697276NoneNone  R83K, S162C, T200A, Q207N, R211K, A272S, K281R, T286A, I329V, G333E, Q334HB
 Pat098ARC-A135JN697281NoneNone  T39TA, K122KE, I142V, D177E, I178M, T200A, Q207HN, R211RK, P243A, V245E, E248D, D250DE, A272P, V276VI, T286TA, V292VI, G333E, Q334HB
 Pat097ARC-A136JN697282NoneNone  T39TA, K122KE, I142V, D177E, I178M, T200A, Q207HN, R211RK, P243A, V245E, E248D, D250DE, A272P, V276VI, T286TA, V292VI, G333E, Q334HB
 Pat096ARC-A137JN697283NoneNone  T39TA, K101KR, K122KE, I142V, D177E, I178M, T200A, Q207N, R211RK, P243A, V245E, E248D, D250DE, A272P, V276VI, T286TA, V292VI, P294PS, G333E, Q334HB
 Pat081ARC-A155JN697298NoneNone  K43KM, K173E, D177E, I178L, V179I, R211RK, I244IV, V245VM, E248D, A272P, T286A, E297R, V314VI, G333E, Q334HB
 Pat067ARC-A171JN697312NoneNone  V60I, D121H, K122E, I178M, R211G, A272P, G333E, Q334HB
 Pat052ARC-A185JN697327NoneNone  K20KR, A98S, I135T, S162C, Q174H, R211K, V245M, D250E, A272P, I293V, T296TS, K311KR, I329L, G333EB
 Pat048ARC-A189JN697331NoneNone  K122E, D123G, K173KQ, D177E, I180V, V189I, A272P, K277R, L283I, I293V, G333E, Q334LB
 Pat043ARC-A193JN697336NoneNone  S48T, K82R, A98AS, K122P, D123DE, K173KE, D177E, Q207N, R211K, D250E, A272S, K277KR, A288T, K311R, I329L, G333E, Q334YB
 Pat035ARC-A204JN697344NoneNone  D123E, Q174H, D177E, I202V, R211K, A272P, V317A, G333E, Q334HB
 Pat020ARC-A224JN697359NoneNone  E6EK, K20R, A98S, K104N, K122E, K166R, T200K, I202V, R211S, A272P, K277R, V292I, I293V, I326V, G333EB
 Pat005ARC-A241JN697374NoneNone  V35A, T39A, K49R, I178M, T200K, Q207E, R211K, A272P, K275KR, K277KR, L283I, I293V, E297T, K311KR, G333E, Q334LB
 Pat004ARC-N29JN697375NoneNone  D123E, I178L, V179I, G196E, F214L, A272P, Q278H, K281R, V292I, I293V, E297K, K311R, V317A, I329L, G333E, Q334HB
 ARC-A128ARC-A128GU565667NoneNone Y188LV35M, V106I, K122KEGR, D123DN, I135IV, D177E, T200A, E203D, R211K, F214L, D250E, A272P, K277R, I293V, E297K, G333EB
Castro (2010)PHI-27PHI-27GQ131622NoneNone  V35T, K103R, S105A, D123E, S162C, R211G, W212WG, E248D, A272P, K277R, T286A, A288S, L301M, S322T, I329L, G333E, P345Q, M357TB
 PHI-26PHI-26GQ131621NoneNone  V35T, K103R, S105A, D123E, S162C, R211G, E248D, A272P, K277R, T286A, A288S, L301M, S322T, I329L, G333E, P345Q, M357TB
Chin (2010)K205K205GQ290739NoneNone  V35I, K64R, K122E, D123T, A158S, K166R, R211K, A272P, T286A, E297K, K311R, S322A, G333E, Q334DB
 K725K725GQ290761NoneNone  K20KR, S162C, R211G, V245I, I293V, E312AV, G333EB
Descamps (2010)80odyssee80odysseeHQ717915NoneNone  D123E, I142V, S162C, Q207K, R211K, T286A, I293V, L303LR, I329V, G333E, Q334LB
 213odyssee213odysseeHQ718046NoneNone  K20R, E169D, R211K, T286A, T296S, E297KR, P313T, G333E, Q334LB
 557odyssee557odysseeHQ718390NoneNone  K49R, V118I, K122E, R211E, F214L, V245E, V276VI, T286A, A288S, P313S, V317A, G333EB
Yebra (2010)22413604SP0224136FJ481738NoneNone  A98S, D123DE, A158S, S162A, E169D, R211K, K277R, T286A, E297K, G333E, Q334LB
 22412404SP0224124FJ481743NoneNone  V21I, V35T, D123E, Q174H, D177E, Q197P, I202V, A272P, L301LI, G333E, Q334LB
 17383104SP0173831FJ481752NoneNone  V118I, K122KQ, D123E, I135T, T165I, D177E, R211G, F214L, K277R, A288S, I293V, K311KR, G333EB
 24943705SP0249437FJ481758NoneNone  K20R, I135T, I178M, D192DN, I202V, Q207QR, R211K, A272P, L283I, I293V, P294Q, G333E, Q334MB
 24942805SP0249428FJ481760NoneNone  V35I, A98S, D123E, A158S, S162D, K166R, E169D, G196GE, R211K, K277R, E297K, G333E, Q334LB
 25609705SP0256097FJ481761NoneNone  E6D, I50V, I142V, A158S, V189I, T200I, R211K, V245N, T286A, V292I, I293V, E297K, L301I, G333EB
 24943105SP0249431FJ481763NoneNone  I142IT, K173EQ, I178ILM, G196GE, T200TI, R211RK, A272P, K277R, T286A, E291ED, V292VI, E297K, K311KR, G333E, Q334HB
 22415205SP0224152FJ481788NoneNone  V35I, K102R, D123E, I135T, D177E, I178M, R211K, K277R, E291D, I293V, E297A, G333EB
 24942505SP0249425FJ481791NoneNone  S68G, D86E, D123E, I135T, N175H, I178L, T200A, R211D, V245VL, A272P, T286A, E297R, S322T, G333E, Q334NB
 25610005SP0256100FJ481796NoneNone  V60I, D123E, I142V, D177E, T200A, V245M, A272P, I293V, K311R, I329ILV, G333E, Q334LB
 24393605SP0243936FJ481803NoneNone  V35I, R83K, I135T, G196E, T200A, R211K, V245M, A272P, K277KR, L283I, I293V, P294S, E297K, G333EB
 30302906SP0303029FJ481824NoneNone  R83K, K122P, D177E, I178IM, T200TI, R211G, V245K, A272P, K277R, T286A, V292I, I293V, E297R, G333EB
 29659106SP0296591FJ481834NoneNone  A272P, K277R, I293V, E297A, P313T, G333E, Q334HB
 32147606SP0321476FJ481846NoneNone  V35I, R83RK, D123E, I135T, Q197P, R211K, I244IV, A272P, K277KR, K281R, E297K, I326M, G333EB
 32146906SP0321469FJ481848NoneNone  R83K, I178M, T200A, R211RK, V245Q, A272P, K281KR, L283LI, I293V, E297A, K311KR, G333E, Q334HB
 30302406SP0303024FJ481863NoneNone  K122E, R211K, E291D, I293V, E297A, I329L, G333EB
 31101506SP0311015FJ481868NoneNone  K122E, S162C, E204Q, Q207E, R211RK, A272P, K277R, I293V, G333E, Q334LB
Kao (2011)Pat19435794HQ657846NoneNone  V8I, K11R, V35T, K122E, I178M, T200R, R211Q, K238R, V245M, A272S, A288S, E297A, K311R, P313R, G333EB
Rolland (2011)2254consensus_2254JF320018NoneNone  M16Q, V35I, K122E, I135T, D192N, I202V, K277R, Q278E, T286A, T296S, E297K, G333E, Q334H, R356K, Q367L, T386I, K390R, A400T, V435A, N447S, D460N, R461K, S468T, Q524E, A554NB
 0839consensus_0839JF320063NoneNone  D123E, S162C, D177E, R211K, V245VM, E248ED, D250DE, A272P, K277R, T286A, I293V, I329L, G333E, F346Y, M357MI, R358RK, T377M, K390R, A400T, E430EK, V435I, L452S, S519NB
 0346consensus_0346JF320083NoneNone  S162C, R211K, T286A, V292I, I293V, G333E, P345Q, K366R, A376S, T403M, V435A, L452S, S468PB
 1478consensus_1478JF320150NoneNone  V35T, E40D, T165I, G196E, Q197K, K277R, D324E, I329V, G333E, Q334N, T369A, A376T, K390R, A400T, K431R, V435A, S468P, H483N, A554S, K558RB
 1512consensus_1512JF320356NoneNone V179DK20R, E40D, K122P, D123E, S162C, D177E, I195L, Q207E, R211K, F214L, A272P, A288S, V292I, E297N, P313T, V317A, G333E, M357T, R358K, K366R, A376T, T386I, K390R, A400T, V435I, N447S, R461K, Q509H, V548IB
 1926consensus_1926JF320361NoneNone  K20R, V35I, D123E, I135T, P176T, R211E, F214L, V245M, T286A, I293V, E297K, G333E, M357T, R358K, D364E, T377K, T386I, A400T, L452I, D460N, S468P, L491S, K530R, I556VB
 2008consensus_2008JF320482NoneNone  D121DY, K122E, S162A, E169D, Q197QE, T200A, R211K, V245IKM, A272P, T286A, I326V, G333E, Q334H, M357T, A360T, A376T, S379C, T403R, V435I, V467I, T470A, K558RB
 0823consensus_0823JF320530NoneNone K103NK20R, T39A, I142V, S162C, G196E, T200I, R211G, V245E, A272P, V276I, E312A, I329L, G333E, R356K, M357S, E404D, V458I, R461K, V466T, T470M, L491V, K512R, V548IB
Sanabani (2011)BR1013BR1013JN692432NoneNone  I50V, V60I, S68G, K122E, I135T, I178L, Q197L, Q207D, A272P, K277R, A288S, I293V, E297A, P313Q, S322A, G333E, Q334R, F346L, I375V, T386I, K390R, T403M, R461K, S468P, A554TB
 BR2041BR2041JN692443NoneNone  I135T, S162C, I178M, G196E, E203D, A272P, T286A, A288P, I293V, P313T, V317A, G333E, Q334R, M357T, A400S, S468P, T470K, H483Y, A502S, K512QB
 BR1070BR1070JN692458NoneNone  K49R, I135T, S162C, D177N, G196D, V245M, T286A, I293V, P313T, V317A, G333E, Q334R, I341T, F346L, M357T, V435G, L469I, H483Y, K512QB
Santos (2011)J184J184_PR_RT_CN_RHJN010585NoneNone  V35M, R83K, D123E, K166R, D177E, I178V, T200I, N255K, A272P, K281R, E297K, G333E, G335S, R356K, K366R, T369A, A371V, I375V, A376T, T386I, A400T, V435I, L452M, R461K, V466I, A554TB
 J259J259_RT_CN_RHJN010663NoneNone  V60I, R83K, K104R, D123E, I178L, T200I, I244V, A272P, K277R, I293V, E297K, G333E, Q334H, T386I, K390R, E399D, A400T, K431T, V435A, L452M, V466I, T470N, D471E, T477A, H483Q, V493A, S519T, K530R, A534S, V548I, A554SB
An (2012)09LNA01409LNA014JX960597NoneNone  V35I, R83K, K122E, D123S, A158S, I195K, T200A, Q207E, R211K, E248D, K277R, A288S, E297K, S322T, G333E, Q334H, V365I, A376T, A400T, V435A, D460N, S468T, Q480K, S519N, I556VB
Avila-Rios (2012)C18TME0SSRC18TME0SSRKC168205NoneNone  T69S, D123E, D177E, T200A, I202V, Q207A, R211K, K277R, P294T, E312T, G333EB
 C280F9DKR2C280F9DKR2KC168216NoneNone  K20R, V35I, A98S, Q145E, I178M, Q197E, T200E, E204K, Q207E, V245E, K287R, I293V, P294T, L310I, G333EB
 C280FK1TS3C280FK1TS3KC168217NoneNone  V35T, D123E, I142V, K166R, D177E, I195IL, Q197K, T200A, Q207A, R211K, K277R, I293V, P294Q, G333EB
 C28EM90GO4C28EM90GO4KC168218NoneNone  V60I, D123E, Y127YS, K173KN, D177E, I178ILM, G196E, T200E, E204N, Q207K, R211RKQ, A272P, T286TA, N306NH, K311KR, E312HN, I326V, G333EB
 M280M5HBS7M280M5HBS7KC169261NoneNone  K32R, V35M, D123E, I135M, S162C, I178L, R211K, A272P, V276I, K277R, I293V, K311R, G333EB
 M800FE4I7FM800FE4I7FKC169269NoneNone  R83K, K122P, D177E, Q207K, R211E, V245M, A272P, V276I, K277R, P294S, D324DE, G333EB
 M800M6AGTGM800M6AGTGKC169270NoneNone  A98S, K122P, A158S, I178L, V179I, G196E, V245K, A272P, K275R, V292I, P294S, E297R, G333EB
 M800M6AUVHM800M6AUVHKC169271NoneNone  A98S, K122P, A158AS, I178L, G196E, V245K, A272P, K275KR, K277KR, V292I, I293IV, P294S, E297K, G333EB
 M800M77HSIM800M77HSIKC169272NoneNone  A98S, K122P, I142V, I178L, G196E, R211RS, V245K, A272P, K275R, K277R, V292I, P294S, E297K, I329IV, G333EB
 M800M7BGQJM800M7BGQJKC169273NoneNone  A98S, K122P, I142V, I178L, G196E, V245K, A272P, K275R, V292I, I293V, P294S, E297K, G333EB
 M8U0M92LVKM8U0M92LVKKC169274NoneNone V108IK49R, V60I, R83K, K122P, D177E, I178M, V179I, T200A, E204K, E248A, A272P, K275R, K277R, E297K, G333E, Q334LB
 C8V0MA3KP8C8V0MA3KP8KC168222NoneNone  V35I, D86E, V118I, D123E, I135T, K173E, Q174R, D177E, R211K, F214L, E248D, I293V, G333EB
 O800M93JT3O800M93JT3KC169473NoneNone  V60I, R83RK, K122P, I135T, D177E, T200A, R211K, V245I, A272P, V276T, K277R, V292I, I293V, L310I, I326V, G333E, Q334LB
 O800ML6QL4O800ML6QL4KC169474NoneNone  V35I, R83K, A98S, K122P, T165I, I178L, V245E, A272P, K277R, Q278N, I293V, T296TS, E297R, G333E, Q334LB
 O8E0M84GK5O8E0M84GK5KC169475NoneNone  D123E, I135T, D177E, R211K, L283I, I293V, P294Q, K311R, I329L, G333EB
 P000M87QX8P000M87QX8KC169514NoneNone  K20R, V35I, D86E, K104KR, K122P, D177EG, Q207QR, A272P, K275R, K277R, Q278E, E297K, L301I, G333E, Q334LB
 P18MMB5KJ4P18MMB5KJ4KC169545NoneNone  G196E, T200A, Q207E, E297R, L301I, I329L, G333EB
 P800F87OVWP800F87OVWKC169572NoneNone  S68G, D86E, K173R, R211K, P243T, V245E, A272P, K275R, V276I, K277R, Q278H, K311R, I329V, G333E, Q334HB
 P800FBABWXP800FBABWXKC169573NoneNone  K49R, K64R, K126P, I135V, Q174H, D177E, R211K, T286A, I293V, E297K, I329L, G333E, Q334HB
 P800FI_OKZP800FI_OKZKC169575NoneNone  D123DE, I135V, S162C, Q174QR, R211K, T286A, V292I, E297R, L301I, I326V, I329L, G333E, Q334HB
 P8V0M81TJ1P8V0M81TJ1KC169577NoneNone  V35VL, I50V, E79D, W88WC, K102KR, V106VI, V118I, K122P, I135IR, I202V, E204D, R211RG, F214L, A272P, K277R, L283LI, L310I, G333E, Q334LB
 V180MD1MSGV180MD1MSGKC169699NoneNone  V35I, I135T, T139S, Q174E, I202V, E204K, Q207E, F214L, V245E, A272P, V292I, I293V, E312T, G333E, Q334LB
 V18IF86CSHV18IF86CSHKC169700NoneNone  K49KR, A98S, I135V, D177N, Q207E, R211K, A288S, E297A, L325I, G333E, Q334VB
 V800F979U2V800F979U2KC169721NoneNone  K32E, V35T, E36A, K122P, I135K, S162C, D177E, I178L, V179I, G196E, T200TI, A272P, K277R, T286P, I293V, E297K, K311R, I326V, G333EB
 V800MF0NB3V800MF0NB3KC169722NoneNone  K122E, T131X, G152X, G196E, L210LF, R211K, A272P, K277R, T286A, E297R, L301I, G333E, Q334HB
 D000MF7TXKD000MF7TXKKC168341NoneNone  K104R, I135T, S162A, D177E, I178M, Q207E, R211K, F214L, I293V, E297K, P313S, V317A, S322T, G333E, Q334HB
 D180M9AIUHD180M9AIUHKC168374NoneNone  V35I, R83K, K122P, S162C, E169D, D177E, A272P, K277R, T286A, E297R, K311R, G333EB
 D18AM86FTID18AM86FTIKC168375NoneNone  D86E, K101Q, K122P, S162C, D177E, V179I, A272PS, K277R, I293V, E297A, I329V, G333E, Q334LB
 D18LMBADTJD18LMBADTJKC168376NoneNone  K64KR, I135T, R211S, F214L, T286A, I293V, E297K, S322T, I329L, G333EB
 D280M61PSFD280M61PSFKC168408NoneNone  K122P, G196E, F214L, S251SC, K277KR, I293V, P294T, K311KR, I329V, G333E, Q334LB
 D280ME4PRID280ME4PRIKC168411NoneNone  K20R, V35I, D123DE, D177E, Q207E, R211K, K277R, A288S, V292I, I293V, E297A, S322T, G333EB
 D7W0M_9BTZD7W0M_9BTZKC168428NoneNone V179DR83K, K122P, S162C, D177E, V245K, D250E, A272P, K277R, A288T, G333E, Q334LB
 D800F9ACV0D800F9ACV0KC168429NoneNone  K20R, V35I, R83K, K122P, S162C, Q174H, D177E, I178L, G196E, R211K, A272P, I293IV, E297EK, G333E, Q334HB
 D800FE1MJ1D800FE1MJ1KC168430NoneNone  R83RK, V90VI, K104R, K122P, I142V, D177E, R211K, A272P, V276I, K311R, G333E, Q334RB
 D800M5ERS2D800M5ERS2KC168431NoneNone  A98S, K122P, Y127Y*, S162C, D177E, I293V, P294S, G333E, Q334SB
 D800M93SL3D800M93SL3KC168432NoneNone  D123E, R211K, F214L, I257L, A272P, K277R, I293V, E297I, V317A, I329L, G333E, Q334HB
 D800MECLL4D800MECLL4KC168433NoneNone  A98S, I135V, I142T, I178M, R211Q, V245E, A272P, K281R, I293V, G333E, Q334LB
 D8A0M79DT6D8A0M79DT6KC168435NoneNone  K101Q, D177G, V179I, Q207E, R211K, A272P, T286A, I293V, P294T, E297K, L310I, L325I, I326V, G333E, Q334HB
 D8M0ME7VV7D8M0ME7VV7KC168436NoneNone  K122E, V245M, A272P, V276I, T286A, I293V, P294A, E297K, G333E, Q334HB
 D8W0M8D8Z8D8W0M8D8Z8KC168437NoneNone V179DR83K, K102R, K122P, D177G, I178M, Q207L, R211K, F214L, A272P, K277R, T286A, I293V, E297K, G333EB
 B800F92LS6B800F92LS6KC168148NoneNone  V35VI, I135T, E169D, D177E, G196E, T200A, E204D, R211S, F214FL, V245M, A272G, T286A, E291D, E297R, K311S, E312K, I326V, I329L, G333E, Q334EB
 B800MG1RT7B800MG1RT7KC168149NoneNone  K49R, V60I, I135T, E169D, N175NY, T200A, A272AGRT, T286TA, I293V, G333EB
 B8FWME2NU8B8FWME2NU8KC168150NoneNone V179DK20R, V60I, T69TI, V118I, D123E, I135T, D177N, I195L, G196E, T200TA, Q207L, R211K, F214L, K277R, A288S, I293V, E297R, E312H, G333E, Q334HB
 B8T0F74DT9B8T0F74DT9KC168151NoneNone  T69S, V106I, D121Y, K122E, D177E, T200A, Q207E, A272P, K277KR, E297A, S322T, G333E, Q334GB
 E180FI0PLNE180FI0PLNKC168665NoneNone  I5IM, V35I, S68G, K122E, D123N, I135T, I178M, I195L, T200A, Q207N, R211K, E248EDV, V292VE, I293V, E297R, L303LR, A304E, L310LQ, E312T, P313PA, H315HQ, G316GE, I329V, G333EB
 E180MCEHUPE180MCEHUPKC168667NoneNone  V35I, R83K, K122P, D177E, I178M, T200A, A272P, V276VI, K277R, T286TA, P294T, E297R, G333EB
 E180MD6RUQE180MD6RUQKC168668NoneNone  K32KN, V35I, R83K, K122P, T139TA, D177E, I178M, T200A, R211RK, A272P, K277R, T286TA, P294T, E297R, G333EB
 E18EM72LTRE18EM72LTRKC168669NoneNone  V35IM, T69TA, K122E, I178M, T200E, E204K, Q207E, I293V, T296S, E297K, E312T, G333EB
 E280FC9CK0E280FC9CK0KC168714NoneNone  K20R, D86E, K101R, K122P, I142A, D177E, V245M, A272P, K277R, P294T, E297K, E312D, G333E, Q334LB
 E580FA0RTRE580FA0RTRKC168741NoneNone  R83K, K122P, E138A, S162A, Q174QR, D177E, I178IM, R211K, V245I, A272P, K277R, T286A, E297A, G333E, Q334LB
 E800FBQBTUE800FBQBTUKC168744NoneNone  I31M, V35I, K82R, K122P, I178L, T200A, Q207R, R211K, V276I, A288S, I293V, E297V, G333EB
 E800FD0SAVE800FD0SAVKC168745NoneNone  K122E, I135T, S162C, G196E, R211RK, A272P, K277R, I293V, E297Q, G333EB
 E800FNA0KWE800FNA0KWKC168746NoneNone  E6D, V35I, K49R, I50V, D123DE, I135L, K173Q, I178MV, V179I, T200A, E204A, R211K, A272P, T286A, A288G, E297KR, S322T, I329L, G333E, Q334LB
 E800M6FGSYE800M6FGSYKC168748NoneNone  D123E, I135T, D177E, R211K, F214L, V276VI, A288S, I293V, E297A, K311R, G333E, Q334EB
 E800M90PUZE800M90PUZKC168749NoneNone  E6D, V60I, I142IT, D177DE, R211REGK, A272S, A288S, I293V, G333E, Q334LB
 E800M97GL0E800M97GL0KC168750NoneNone  E28EA, D123E, I142T, G196E, K275R, V276I, E291D, I293V, P294T, E312Q, G333EB
 E800M99JJ1E800M99JJ1KC168751NoneNone  V35M, R83K, K122E, S162CY, D177DN, T200E, R211RK, K277R, T286A, A288S, E297A, G333EB
 E800MA0QT2E800MA0QT2KC168752NoneNone  R83RK, K122P, S162C, D177E, I178LM, Q197QK, R211K, V245I, A272P, V276T, K281KR, P294T, S322A, G333EB
 E800MA5DV3E800MA5DV3KC168753NoneNone  S162C, R211K, A272P, K277R, A288S, I293V, K311R, G333EB
 E800MB8FK5E800MB8FK5KC168755NoneNone  K49R, V60I, K64R, K102R, I135T, E169D, E194Q, G196E, D250E, S251N, I257L, K277R, T286A, A288S, V292I, I293V, P294ST, E297R, V317A, I329L, G333EB
 E800MBJEU6E800MBJEU6KC168756NoneNone  K11Q, K122P, I135R, I142M, K173KE, D177E, I178L, A272P, K277R, P294S, G333E, Q334YB
 E800MCALU7E800MCALU7KC168757NoneNone  K20R, V35I, R83K, K122P, S162C, Q174H, D177E, I178L, G196E, R211K, A272P, G333E, Q334HB
 E800MD0RT8E800MD0RT8KC168758NoneNone  E53D, K102Q, K122E, S162Y, V179I, I202V, R211K, T286A, E297K, S322T, D324E, G333EB
 E8W0FD2JTAE8W0FD2JTAKC168760NoneNone V179DT27S, R83K, K122P, I135IV, A158S, D177E, R211K, A272APS, K275KR, K277R, T286A, V292VI, I293V, E297R, L301I, V317G, G333E, Q334LB
 E8W0M80KTBE8W0M80KTBKC168761NoneNone V179EK20R, V35L, T39A, R83K, I135T, I142V, I178L, R211RK, F214L, A272P, I293V, P294Q, K311R, I329L, G333E, Q334YB
 E8W0M96GKCE8W0M96GKCKC168762NoneNone V179DK20R, R83K, K102R, K122P, D177E, R211K, V245K, A272P, K277R, I293V, G333EB
 E8W0ML0TTDE8W0ML0TTDKC168763NoneNone V179DT27S, V60VI, R83K, D86E, V90VI, K122P, I135V, D177E, Q207QE, R211K, A272P, V276IT, K277R, T286A, A288PS, I293IL, E297R, G333E, Q334LB
 E8X0MD0PUEE8X0MD0PUEKC168764NoneNone V179EK20R, V35L, R83K, I135T, I142V, I178L, F214L, V245E, A272P, I293V, P294Q, I329L, G333E, Q334YB
 EC00M7DISLEC00M7DISLKC168771NoneNone  E6D, V60I, K126KN, I135T, W153R, D177E, V179I, A272S, A288S, I293V, G333E, Q334LB
 G280MB6NRJG280MB6NRJKC168877NoneNone  K20R, I135IATV, K173KE, R211KQ, F214FL, I293V, V317VA, D324E, G333E, Q334KB
 G800M72RUOG800M72RUOKC168882NoneNone  K122P, I135T, S162C, D177E, I178M, R211K, V245X, A272P, V276T, P294T, L310I, V314VI, S322A, G333E, Q334LB
 I800M91QT4I800M91QT4KC168898NoneNone  V21VI, I50IV, V60VI, K102KR, I135V, I142IV, K173KDEN, I178IL, R211RK, V245KN, A272P, L283LI, I293IV, E297EA, G333E, Q334DB
 J180F72NRLJ180F72NRLKC169023NoneNone  V60I, S68G, D121Y, K122E, I135T, K166R, I178L, Q207E, R211K, A272P, K277KR, T286A, V292I, E297R, E312T, G333EB
 J180MA4TQNJ180MA4TQNKC169025NoneNone  V35I, S68G, K122E, I135T, T200A, Q207E, V245E, K277R, Q278QE, T286A, E297K, G333E, Q334DB
 J18CFB0EURJ18CFB0EURKC169029NoneNone  E6ED, K11KR, V35I, R83K, K103R, K104R, I135T, S162H, V179I, H208HY, R211K, F214L, V245Q, A272P, K277R, T286A, A288S, D324DE, G333E, Q334HB
 J280FE0OQDJ280FE0OQDKC169051NoneNone  V35I, S162N, I202V, R211K, A272P, K277R, I293V, E312ED, G333EB
 J580MC5LSVJ580MC5LSVKC169069NoneNone  K49KR, K64KR, K122E, I135IK, E138EA, I142IT, S162C, D177E, I178IM, E248D, T286A, A288S, I293V, P294PT, E297T, G333EB
 J800M5HBXYJ800M5HBXYKC169072NoneNone  V35L, T39A, R83K, I135T, I142T, S162A, R211K, V245K, K277R, T286A, A288S, I293V, K311KR, D324E, G333EB
 J800MA2RIZJ800MA2RIZKC169073NoneNone  K20R, V35I, I178M, V179I, G196E, Q197K, E204D, Q207A, R211K, V245K, D250E, A272P, E297K, I326V, G333EB
 J800MA4OU0J800MA4OU0KC169074NoneNone  V35VI, K64R, D123E, K166R, D177E, T286A, I293V, T296S, E297EK, L301LI, G333E, Q334HB
 J800MA4TT1J800MA4TT1KC169075NoneNone  V8I, K20R, V35M, D123E, E194Q, G196E, F214L, A272P, I293V, E297T, K311R, D324E, G333E, Q334HB
 J800MABHT2J800MABHT2KC169076NoneNone  V35IM, D86E, K102Q, D123E, I135IRT, S162C, I178M, T200A, R211K, A272P, V276I, T286A, A288T, I293V, E297K, G333EB
 J800MAEJT3J800MAEJT3KC169077NoneNone  I135T, I178M, V189I, Q197L, I202V, R211S, F214L, V245R, T286S, E297K, V317A, I326V, I329L, G333EB
 J800MBEKV4J800MBEKV4KC169078NoneNone  P4S, V35I, R83K, D177E, I178M, A272P, K277R, A288G, I293V, E297R, L301I, K311R, G333EB
 J800MD6OR6J800MD6OR6KC169080NoneNone  K64R, K122KE, S162C, D177E, T200TA, R211RK, L228LH, K277KR, Q278QH, T286A, A288S, I293V, E297R, D324E, G333EB
 J800MDEJJ7J800MDEJJ7KC169081NoneNone  I135T, R211K, F214FL, K277R, T286P, I293V, E297K, E312D, G333E, Q334QHB
 J800MH0PU8J800MH0PU8KC169082NoneNone  E6K, V10A, V35VI, K122E, A158AT, D177G, T200E, R211K, A272P, I293V, I329L, G333E, Q334HB
 J800MJ0TT9J800MJ0TT9KC169083NoneNone  V35I, D121Y, K122E, T139A, D177E, A272P, V292I, G333EB
 J800MR2QSAJ800MR2QSAKC169084NoneNone  K122E, D123E, I142V, D177E, T200A, R211K, F214L, A272P, T286A, V292I, P294S, E297K, G333EB
 J8AWMP0NSBJ8AWMP0NSBKC169085NoneNone V179DK101Q, I135R, S162C, D177E, G196E, T200A, Q207H, R211K, K277R, T286A, A288S, I293V, P294T, E297R, D324E, G333EB
 J8B0MD2RRCJ8B0MD2RRCKC169086NoneNone K103N, K238TV35VL, D121H, K122E, S162C, D177E, K277R, T286A, A288S, I293V, E297R, P321PS, D324E, G333EB
 J8M0F9BMUEJ8M0F9BMUEKC169088NoneNone  D123E, S162C, D177E, T200A, R211K, A272G, K277R, T286A, A288S, I293V, E297K, G333EB
 J8W0M93MRHJ8W0M93MRHKC169091NoneNone V179DM16T, K20R, E28A, V60VI, R211K, V245E, S251I, A272P, T286TA, V292I, I293V, T296S, E297A, G333E, Q334RB
Machado (2012)CUPL1111CUPL1111JX194190NoneNone  D123E, S162C, D177E, T200A, E203D, R211K, V245Q, A272P, K277R, T286A, V292I, E297A, I329V, G333E, M357I, R358K, G359S, A376S, E396NB
Ferreira (2013)BR09SP264BR09SP264HM534128NoneNone  S68G, V189VI, T200TA, Q207H, R211K, V245E, K281R, I293V, E312AT, G333E, Q334LB
Hawke (2013)1359922 H1359922 HKC237928NoneNone V179DK64R, K102KE, K122T, Q207E, R211K, F214L, V245L, E248D, T286A, I293V, E297K, H315Y, G333E, Q334H, R356K, M357T, K390RB
 4533722 H4533722 HKC238160NoneNone  D123E, S162A, T200TA, Q207A, R211K, V245K, P247PQ, K277R, A288S, I293V, P294A, E297K, G333E, Q334E, K350R, A360T, E370G, K390RB
Heipertz (2013)306308_RT306308_RTJX863943NoneNone  K20R, V35L, G45E, K122E, S162C, K173Q, R211K, A272P, K281R, P294Q, S322T, G333E, G359S, K366R, E399D, A400T, E404D, E432DB
Holguin (2013)ES121ES121JX466990NoneNone  K20R, V60I, D123N, I135T, Q174E, I202V, A272T, I293V, K311R, E312K, I329L, G333E, Q334HB
Kiertiburanakul (2013)X12016X12016KC994353NoneNone  K166KR, E169D, I178IM, T200A, Q207E, A272P, L282LP, V317T, G333E, G335C, P345Q, F346Y, R356K, M357L, K366R, K385R, T386I, K390R, A400TB
 X12056X12056KC994388NoneNone  E6D, V35VI, V60I, T107S, K122KE, K166R, N175Y, G196E, T200A, Q207E, V245VM, A272P, T286TA, I293V, V317A, S322ST, I329V, G333E, R356RK, A371AV, K390RB
 R12036R12036KC994189NoneNone  E6K, A98S, K122E, D123E, I135T, E204EQ, Q207DE, R211K, V245E, D250E, L283LF, I293V, K311R, P313Q, G333E, A376T, T386IB
Kijak (2013)05TH51894405TH518944JN248350NoneNone  I142T, I178L, I180L, T200I, R211E, A272P, I274V, T286A, E297K, I309L, G333E, Q334Y, Y342F, M357V, K366R, A376V, T386I, K390R, A400I, T403M, E432D, N447S, D471E, Q480H, G490E, L491S, K512R, L517V, S519N, Q524E, K530R, A534S, Q547K, A554SB
Leye (2013)SN.MS605SN.MS605FM210727NoneNone  K32R, V35I, K43Q, R83K, G196R, P243T, V245E, A272P, V276T, T286A, I293V, G333E, Q334M, M357T, A376T, T377K, T386V, K390R, A400S, E432DB
 SN.MS019SN.MS019FM210690NoneNone  V35T, K49R, I50V, V60I, R83K, E138S, K173Q, R211K, V245N, A272P, V276T, I293V, E298G, G333E, Q334M, T338S, M357A, K390R, A400S, T403M, E404D, E413D, E432DB
 SN.MS619SN.MS619FM210730NoneNone  K32R, R83K, S162C, G196R, R211K, P243T, V245E, A272P, V276T, T286A, I293V, G333E, Q334M, M357T, A376T, T377K, T386V, K390R, A400S, E404DB
 SN.MS103SN.MS103FM210693NoneNone  V35M, S48T, K49R, R83K, E138A, S162C, K173Q, T200A, R211K, V245N, A272P, V276T, Q278K, I293V, E297G, G333E, Q334M, T338S, M357T, K390R, A400S, T403M, E404D, E413D, E432DB
 SN.MS614SN.MS614FM210728NoneNone  S48T, K49R, R83K, E169D, I178L, G196K, R211K, V245E, A272P, V276T, K281R, G333E, Q334M, R356K, M357T, A360T, A376T, T377K, T386I, K390R, A400T, T403PB
Li (2013)28522852JQ901061NoneNone  V106I, V118I, D121H, K122E, E169D, I202V, F214L, V245L, V261I, T286A, A288S, I293V, E297H, I329L, G333E, M357T, S379G, K385R, T386I, A400T, E432D, E449D, S468T, L469I, T470A, V548A, A554S, V559IB
Tramuto (2013)CV1330_121CV1330_121HQ667700NoneNone  D123E, I135T, I167V, D177E, R211K, V245K, K277R, Q278H, I293V, K311R, I329L, G333EB