<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype B
Gene RT
Mutation G333E
Rx >= 1 NRTI
(but no NNRTI)
IncludeMixtures No
References 18
Patients 73
Isolates 80
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Lin (1994)PFL-011PFL011B AZTNone  R83K, R211K, A272P, K277R, E297K, I329L, G333E, F346Y, A376T, T386I, E399D, A400T, D460N, S468P, S519NB
  PFL011W78 AZT, D4TNone  R83K, R211K, Q242L, A272P, K277R, E297K, D324E, I329L, G333E, F346Y, V365I, A376T, T386I, E399D, A400T, D460N, V466I, S468P, H483Y, S519NB
Hammer (1997)ACTG320_10001000 AZT, DDI, D4TNoneM41L, D67N, K70R, L74I, T215FY, K219Q V35I, E44ED, I50V, D123E, D177E, I178IM, E203D, V245T, A272P, K277R, P294T, E297R, G333E, Q334HY, R356K, G359GS, V365VI, T377S, K390R, T403AV, K431T, L452M, T470S, L486XB
 ACTG320_10311031 AZT, DDINoneD67N, K70R, T215F, K219Q K20KR, D123E, I135T, G196E, Q207E, R211K, V245K, T286A, I293V, D324E, G333E, R358RK, D364E, T377R, T403V, E404D, Y405H, N418S, V435I, R461K, L469I, T470PB
 ACTG320_11311131 AZT, DDCNoneT215CY K20KR, D123E, I142V, S162C, Q197E, R211K, K277R, I293V, G333E, P345Q, G359GS, A371AV, T386I, K390R, E396D, A400T, D460N, R461K, S468T, Q487XB
 ACTG320_115115 AZT, DDCNoneM41L, T69D, L210W, T215Y T39A, E44D, V118I, K122KE, S162T, E203K, Q207A, H208Y, R211K, K223E, L228R, A272P, K277R, G333E, G359S, V365I, A376S, T386IB
 ACTG320_11621162 AZT, DDCNoneM41L, L210LW, T215Y R83RK, K122Q, D177E, T200A, Q207QR, R211RK, A272P, T286A, I293IV, E297K, G333E, Q334LB
 ACTG320_11661166 AZTNone  K20R, R211RK, K277R, I293IV, K311KR, P313T, Y319F, G333E, Q334H, T386I, A400T, Y405H, V435A, L452LIB
 ACTG320_11981198 AZT, DDINoneM41L, L74LV, T215DY181YCV35VI, E44ED, R83RK, I135IT, I195L, V245VM, E297K, I329L, G333E, Q334H, R356RK, M357V, A376T, K390R, A400T, D460NB
 ACTG320_14121412 DDC, AZTNoneM41L, D67N, K70R, L210W, T215Y T39A, V60I, W88C, D123DE, I178IM, G196E, E203D, H208HY, R211K, A272P, I293V, L295Q, T296S, E297K, I329L, G333E, Q334H, M357T, G359S, V365I, K390R, A400T, Q428E, V435I, E449D, D460N, H483YB
 ACTG320_17291729 DDC, AZT, D4TNoneD67N, K70R, T215Y, K219Q V60VI, T200I, Q207E, R211K, V245R, K277R, T286A, I293V, E297K, I329L, G333E, M357I, R358K, E370D, K390KR, Q394H, A400TB
 ACTG320_17361736 AZTNone  K122KE, S162A, V245X, E248ED, D250DE, S251SN, A272P, I293V, G333E, Q334H, G359S, I375V, A376S, T377M, T386TI, T403M, E432D, V435VI, A446SB
 ACTG320_18531853 AZT, D4TNone  I142V, T200I, R211K, V245VE, E248ED, K249Q, A272S, T286A, K311R, S322A, G333E, R356K, A360AT, A376V, K385R, K390R, A400T, V435E, A437V, V458IB
 ACTG320_21132113 AZT, DDINoneD67N, T69TADN, K70KR, T215F, K219Q K20R, T39A, A98S, V106I, V118VI, K122Q, I135IV, I178L, F214L, L228H, V245T, K277R, T286A, E297K, G333E, M357T, G359S, K366R, A376T, T386I, K390R, A400T, K431T, K451R, L452LS, D460N, R461K, V467VI, H483Y, L486XB
 ACTG320_23372337 AZT, DDINoneM41L, D67N, T69D, L210W, T215Y, K219N K20R, V35E, T39A, E40F, K43E, V118I, K122KE, E138G, I142T, S162C, G196E, Q207E, R211K, V245VE, A272P, K277R, I293V, E297A, G333EB
 ACTG320_23392339 AZT, DDINoneD67N, K70R, T215F, K219Q K64KN, D121DN, E203ED, R211K, D218DE, A272P, T286A, A288AG, I293IV, E297K, K311R, I326V, G333E, Q334I, M357MT, K366KR, T369AV, A371V, I375V, A376T, T377TIM, K390R, A400T, T419TI, V435VAIT, D460N, R461K, S468T, H483YB
 ACTG320_25162516 AZT, DDI, D4TNoneD67G, K70R, K219Q V35M, S68G, D177DE, I178M, G196GE, I202IV, Q207H, R211K, A272P, K277R, T286TA, E297K, E312EA, V317A, D324P, I329V, G333E, G335S, V365I, A376S, T386I, D460N, L469FB
 ACTG320_25552555 AZT, DDCNoneD67DGNS, K70R, T215F, K219Q S68SG, T69TN, D121Y, K122E, D177E, I178L, Q197P, Q207QE, A272P, K277R, G333E, G335S, R356K, A360T, K390R, V435M, D460DN, R461KB
 ACTG320_26482648 AZT, DDI, DDC, D4T, 3TCNoneM41L, A62V, D67E, L210W, T215Y K43Q, I50IV, S68MV, W88C, V118I, K122E, S162SG, N175Y, R211K, A272P, K277R, I293IV, I329V, G333E, G359S, A371V, A376T, A400T, K451KR, D460N, Q487XB
 ACTG320_271271 AZT, DDINoneM41ML, D67N, K70R, T215Y R83RK, S162CW, I178L, V245E, A272P, K277R, P294PS, E297K, L301LI, G333E, Q334HY, M357MV, A360AV, A400T, L452LS, D460N, Q480XB
 ACTG320_27792779 AZTNoneD67DN, K70R, T215Y, K219KQ D123E, D177E, Q197QP, Q207E, R211K, F214L, T286A, V292I, I293V, E297K, G333E, Q334H, T338S, A360AT, T377L, K390R, I393IM, A400T, V435I, D460NB
 ACTG320_36113611 DDI, AZTNone  E6D, T27TP, S68SN, K102KR, G196GE, Q207T, L210ST, V245T, E248DN, I293V, K311R, I326V, G333E, Q334H, R356RK, M357MI, R358RK, T377R, T386I, A400T, Y405YH, K431T, V435VA, V466A, H483Y, D488XB
 ACTG320_376376 AZTNoneM41L, T215Y V35VIM, R211K, A272P, I293V, G333E, Q334N, R356RK, G359GS, A371AV, T386I, K390R, A400I, D460N, R461K, S468C, Q480XB
 ACTG320_39683968 AZT, DDCNoneM41L, D67N, T69D, L210W, T215Y K22KN, E28A, V35L, E44ED, R83K, K104N, V118VI, K122KE, S162SG, I178L, H208HY, R211RK, A272P, K277R, E297K, K311R, G333E, Q334H, R356K, K366R, T386I, A400T, V435I, D460N, Q480XB
 ACTG320_546546 AZT, DDINoneF77FL, F116FY, Q151M, K219KE K49R, E53D, L205LF, R211K, A272P, K277R, I293V, E297R, L301I, I329IV, G333E, Q334H, I375V, T377TI, E404D, S468P, T470AB
 ACTG320_706706 AZT, DDC, D4TNoneD67N, K70R, T215TFIS, K219Q V35M, T39TA, K64KN, K103KR, K122KE, I178IM, E203K, E248V, A272P, E297K, I329L, G333E, R358K, A376T, K390R, A400T, V435I, D460S, H483Y, L491XB
 ACTG320_763763 DDI, AZT, D4TNoneD67N, T69D, K70R, T215F, K219Q K20R, V35L, K104R, I135V, K173E, Q207E, R211RK, L283I, R284K, I293V, P294T, G333E, Q334H, R356RK, A360T, V365I, I380V, T386I, K390R, I393M, S468T, L469I, T470AB
 ACTG320_795795 AZTNoneK70R K11KQ, V35I, T39A, S48T, K104N, V245M, A272P, T286A, V292VI, I293IV, T296TS, E297K, V317VA, G333E, Q334H, A360T, Q367L, I375V, T403M, S468PB
 ACTG320_969969 AZT, DDINoneL74LV, T215TADN K122E, Q174H, D177DG, I178IL, Q207QK, H208HY, R211K, V245M, A272P, E297K, I329L, G333E, Q334CHRY, R356K, A360T, A400T, V435T, L452LS, D460N, T470TAB
 ACTG320_978978 AZT, DDINone  T39TA, A98S, K122KE, I135RT, K173N, Q207QH, R211K, F214L, V245VM, L283I, I293V, E297A, K311R, G333E, Q334H, M357T, T377K, K390R, E404D, L452I, L469I, T470TN, L486XB
Coakley (2000)EC15EC15F D4T, DDINone  Q207E, R211K, V245M, I293V, E312N, I326V, I329V, G333E, M357T, A376S, V381I, K390R, K395R, D460N, R461K, V467I, L469I, L491S, A554T, K558RB
 EC24EC24F D4T, DDINone  S162C, Q207E, R211K, V245M, I293V, E312N, I329V, G333E, M357T, T369P, A376S, K390R, T397P, D460N, R461K, V467I, L491S, T497P, K512R, A554T, K558RB
  EC24PF D4T, DDINoneD67N A158S, Q207E, V245M, W266R, E312N, I329V, G333E, E344G, M357T, A376P, V381I, K390R, P421S, L425I, D460DN, S468PT, H483HY, K512KQ, S519SNB
 EC26EC26F D4T, DDINoneV75TV179DD123E, D177E, V245M, A272S, K277R, I293V, G333E, Q334H, T338S, M357I, T377L, A400T, T470N, K512I, E516K, V548IB
Bacheler (2001)DMP003-2803-28000AF349335NRTINoneM184V E28EG, K122E, D123E, S162C, D177E, T200TA, Q207E, R211K, V245VI, A272P, K277R, Q278N, T286A, I293V, D324E, G333E, R358K, G359S, K390R, A400XB
 DMP003-9403-94242BAF349369NRTINoneM41L, T215D V60I, R83K, R211K, A272P, I293V, G333E, Q334Y, M357T, K390RB
 DMP004-14304-143000BAF349400AZT, 3TCNoneM184V V35R, K49R, V60I, K166I, D177E, I178M, T200A, Q207E, A272P, T286A, E297K, G333E, Q334Y, M357T, G359GS, E370D, K390RB
Gonzales (2001)CA1825CA4911AY030738AZT, DDI, D4T, 3TCNoneM41L, M184V, L210W, T215Y E28EG, K43Q, V118I, K122KE, Q174R, I178IM, Q207E, R211K, A272P, E291D, A304G, E305GR, N306X, G333E, Q334H, T338S, K390R, A400T, T403TM, D460N, V467VI, S519N, E529D, K530KR, I556V, K558RB
 CA2256CA9177AY030842AZT, DDC, 3TC, D4TNoneM41L, L210W, T215Y K11R, V35I, K43N, E44ED, R83K, G196E, T200A, Q207E, H208HY, R211K, L228HR, V245E, A272P, K277R, Q278H, T286A, E297R, G333E, R358RK, A360AT, A400L, E404N, N418S, L452A, D460N, H483Y, A554SB
 CA6495CA16029AY032446AZT, DDI, D4T, 3TC, DDCNoneD67N, T69D, K70R, M184V, K219Q K20R, T39A, K82KR, I135V, E169D, Q174N, F214L, L228H, A272P, I293V, T296S, I309IT, K311R, D324E, G333E, Q334H, R356K, M357I, A360T, T369A, K374R, A376N, E404D, L469I, T470P, D471DE, K476KR, S519N, A554TB
Kempf (2001)DK-6273DK-6273 NRTINoneM41L, D67N, K70R, L210W, T215Y, K219H I5V, E6D, K20R, E44D, V60I, V118I, D123E, D177E, G196E, T200I, E203D, Q207E, H208Y, R211K, L228H, T286A, I293V, E297K, I329V, G333E, Q334Y, M357T, E399DB
Gibb (2002)DMG5757_w38 ABC, 3TCNone  V35IM, V60VI, R83EK, K103KR, D123E, F130FC, I178IM, G196E, R211K, A272P, K281R, A288S, I293IV, E297K, I329L, G333E, M357T, K366KR, T369V, I375IV, A376T, K390RB
Maxeiner (2002)380686f380686fpre AZTNone  S162C, Q207E, A272P, K277R, T286A, T296S, E297K, I329L, G333E, G335S, A360T, T386I, A400T, V435I, L452A, D460N, R461K, S468H, S519NB
  380686f+ AZT, D4TNone  S162C, Q207E, V245VA, A272P, K277R, T286A, T296S, E297K, I329L, G333E, G335S, A360T, T386I, A400T, Y405YH, V435I, L452A, D460N, R461K, S468H, S519NB
 501229e501229e+ D4TNone  T27TS, R83K, K173N, Q174K, I178L, T200A, V245E, A272P, K277KR, V292I, E297K, G333E, Q334H, V365I, A376T, K390R, V435VA, D460N, L469LI, L491LS, A554NS, K558RB
Gonzales (2003)CA1825CA16946AF514119AZT, DDI, D4T, 3TCNoneM41L, M184V, L210W, T215Y K43Q, S68G, V118I, K122KE, I135IV, Q174R, T200A, Q207E, R211RK, E224ED, A272P, E291D, D324E, G333E, Q334H, T338S, K390R, A400T, T403TM, D460N, V466VI, V467VI, T470TP, L491LS, S519N, Q524QE, E529D, K530R, I556V, K558RB
Dumans (2004)RG034RG034AY390208AZT, 3TCNoneD67N, K70R, M184V, L210LW, T215Y, K219KQ K30R, K122E, I135T, E169D, I202V, Q207E, R211K, A272P, K277R, V292I, I293V, E297A, K311R, V317A, I329V, G333E, Q334LB
Gulick (2004)RG165RG165w130 ABC, AZT, 3TC, D4TNoneM184V E6K, S48T, D123E, I135V, D177E, I178M, T200A, V245T, A272P, K277R, T286A, E297K, L310I, S322A, G333E, Q334H, W337W*, K366R, A376V, T386IB
Non-B Workgroup (2005)BR7BR7 AZT, 3TCNoneD67N, K70R, M184V, L210LW, T215Y, K219KQ K30R, K122E, I135T, E169D, I202V, Q207E, R211K, A272P, K277R, V292I, I293V, E297A, K311R, V317A, I329V, G333E, Q334LB
Rhee (2005)CA3888CA34583AY801184D4T, DDINoneD67N, K70E, V75T K11A, V35T, D86E, V106I, I135V, I142V, G196E, Q197K, Q207E, A272P, I293V, E297V, G333E, Q334H, M357I, A376T, T386I, V435E, D460N, R461K, L469I, L491S, L517I, S519N, Q520K, K527N, A534TB
 CA4743CA34921AY8013873TC, D4TNoneM41L, D67G, T69D, K70R, M184V, T215F T7TA, K20KR, T39TA, S68G, I135T, S162Y, Q174H, I178IM, Q207E, L228LHQ, A272P, A288S, E297K, G333E, R356K, A360T, A376S, T386I, K390R, A400T, N418S, K431N, V435A, L469I, T470P, H483Y, L491S, I506L, S519N, E529D, K530R, V531I, I556VB
 CA6799CA38087AY801696AZT, DDI, D4T, 3TCNoneD67N, K70R, M184V, K219Q S48T, T69TN, D121Y, K122E, D123DE, E169D, D177E, T200A, Q207K, F214FL, L283I, I293V, P294T, I326V, G333E, Q334N, G335S, R356K, V365VI, T377R, T386I, K390R, T403M, V435L, T470P, Q524E, Q547RB
 CA7884CA19929AY801812AZT, D4T, DDINoneF77FL, Q151M, N348I K22KR, R83RK, K166R, T200A, F214L, A272P, K277R, Q278QE, T286A, I293V, P294S, E297A, G333E, Q334H, I341F, K366R, A376AT, T386TI, A400T, T470A, H483Y, E516D, S519N, Q520N, K527N, K530R, A554SB
 CA8411CA35072AY8020043TC, D4TNoneM41ML, M184V, L210W, T215Y K32KR, V35VGIR, K43KE, N57NK, R83RK, I135IV, I142GV, S162CY, R211K, V245EK, A272P, K277R, I293V, V317A, G333E, Q334H, A360T, A376C, T377N, K390R, A400T, V435E, D460N, S468T, L469I, T470H, S519N, Q520K, K530R, A554NB
  CA41331AY8020053TC, D4TNoneT215TS V35I, S162C, R211K, V245VE, A272P, K277R, I293V, V317A, G333E, Q334HB
 CA8424CA34455AY802009AZT, 3TCNoneM184V R83K, I135L, S162CY, Q174H, I178L, R211G, A272P, K277R, T286A, G333E, Q334H, K390R, D460N, R461K, V466I, V467I, H483Q, S519N, V548IB
 CA9881CA34472AY802162AZT, 3TC, D4T, DDINoneD67N, K70R, T215TI, K219Q T39A, K64HN, S68Y, T69S, K103R, K122KE, I135L, F214L, A272P, T286A, V317A, D324E, G333E, Q334H, D364E, D460N, T477A, I482IV, H483Y, S515T, L517I, K527NB
 CA9974CA24720AY802223DDC, AZT, 3TC, D4T, DDINoneD67N, K70R, T215FV, K219Q K11KR, K20R, T69TA, D123E, I178L, Q197H, I202IV, R211E, V245Q, A272P, G333E, R356K, G359S, K390R, A400T, K454R, R461K, V466S, V467I, T470P, D471DNB
 CA14302CA34507AY802297AZT, 3TCNoneM184V R83K, K122E, I135IV, V179VI, F214L, A272P, K277Q, Q278K, E297Q, G333E, G359S, T369V, A371V, I375V, A376T, K390R, A400T, D460N, A554SB
 CA14487CA34805AY802352D4T, 3TCNoneD67N, K70R, M184V, T215TI, K219Q K20R, T39A, A98S, K104N, D123E, K166R, D177E, T200E, F214L, V245E, A272P, I293V, S322T, G333E, G359S, A360T, T369V, K390R, E399D, A400T, E449D, L452V, D460N, R461K, S468T, H483Y, Q524E, A534S, I556V, K558RB
 CA14587CA34984AY802386AZT, 3TCNoneM41L, D67DN, M184V, T215TNSY K122E, I135IATV, T200A, Q207E, A272P, K277R, T286A, G333E, Q334H, K390R, D460N, R461K, V466I, V467I, H483Q, S519N, V548IB
 CA14611CA48210AY802390AZT, 3TCNoneM41L, M184V, L210W, T215Y K43Q, S68G, K122E, K166R, T200I, R211K, A272P, I293V, G333EB
 CA16262CA38675AY802466AZT, D4T, 3TC, ABCNoneM41L, D67HN, K70R, L74I, M184V, L210W, T215F, K219QA98GV8VI, K20R, T39TAEK, V60I, T69N, K122E, I135T, S162SN, K166R, G196E, H208Y, R211K, D218E, A288S, I293V, I329V, G333E, R356K, A371V, K390R, E399D, K454R, V466T, V467I, H483Y, E492D, S519N, Q547R, A554TB
 CA16323CA41397AY802477DDC, AZT, D4T, 3TCNone  E6EK, K122E, D123E, I142IT, D177E, I178M, R211S, A272AP, K277R, T286A, V292VI, I293V, E297A, G333E, T338SB
 CA16329CA38813AY802480AZT, 3TC, ABCNoneM41L, D67N, M184V, L210W, T215Y K43KDEN, E44D, V111I, D123E, S162FY, I178L, G196E, T200A, E203ED, H208F, R211KN, A272P, K277R, I293V, E297A, E312ED, G333E, P345Q, R356K, G359S, A371V, K390R, A400T, T470P, H483Y, L491S, S519N, E529D, V531I, Q547R, A554T, K558RB
  CA42770AY802481AZT, 3TC, ABCNoneM41L, D67N, M184V, L210W, T215Y K43KDEN, E44D, V111I, V118VI, D123E, S162F, I178L, V189VI, G196E, T200A, E203D, H208F, R211KN, A272P, K277R, A288AT, I293V, E297A, G333E, P345QB
  CA42772AY802482AZT, 3TC, ABCNoneM41L, D67N, M184V, L210W, T215Y K43KDEN, E44D, V111I, V118VI, D123E, S162F, I178L, V189VI, G196E, T200A, E203D, H208F, R211KN, A272P, K277R, A288AT, I293V, E297A, G333EB
Riddler (2008)RG25563RG25563w11 AZT, 3TCNone  E6ED, K11KT, V35I, R83K, Q197P, T200AE, Q207E, R211K, V245E, K277R, I293V, E297R, K311KR, G333E, Q334H, R356RK, K366R, K390R, E399ED, A400ATB
 RG31923RG31923w67 AZT, 3TCNoneM184V K20R, V60I, K64R, Q174N, A272P, K277R, T286V, V292I, E297R, K311R, I326V, G333E, R356K, R358K, Q373H, K390RB
 RG41688RG41688w13 AZT, 3TCNone  E6D, K20R, V60I, R83K, D123E, T200I, R211RK, A272P, K281R, T286A, E297K, K311R, D324E, G333E, Q334N, A360V, Q373N, K390RB
 RG56208RG56208w11 TDF, 3TCNone  K104KR, K122E, D123N, K173E, I178M, V245E, E248D, A272P, I293V, K311R, G333E, Q334C, G359S, K385R, K390RB
 RG60519RG60519w24 AZT, 3TCNone V179VDINK20R, D121C, K122E, A158S, S163ST, T165I, K166KR, E169ED, D177E, R211K, F214L, V245N, A272P, K277R, V292I, I293IV, E297K, V317A, G333E, Q334H, P345Q, M357T, T386TNB
 RG66956RG66956w138 AZT, 3TCNone  V60VI, S68G, R83K, D123E, S162C, T200TA, Q207HN, R211K, L228H, K277R, T286A, A288S, I293IV, E297K, G333E, T338S, V381VI, K390RB
Rosen-Zvi (2008)7502p75-1 AZT, DDC, 3TC, D4T, DDINoneM184V E6EK, V35VI, R83K, K102R, R211K, K277R, T286A, E297K, G333EB
Rhee (2009)CA14271CA34449FJ983358AZT, 3TCNoneM184V V35VAIT, R83K, R211K, A272P, K277R, T286A, I293V, E297T, G333E, A371V, K390R, A400T, D460N, H483Y, L491S, Q547R, K558RB
 CA16474CA39134FJ983424AZT, 3TCNoneM184V K20R, K122E, I178V, G196E, Q207R, R211K, F214L, A272P, V276IT, K277R, T296S, E297R, V317A, D324P, G333E, G335S, R356K, R358K, K395R, E399D, V435A, R461K, Q464H, L469I, T470A, H483L, L517I, V531I, A534T, A554N, K558RB
 CA17695CA41633FJ983454D4T, 3TCNoneM184V V35I, R83K, K122KE, I178L, Q207E, R211K, P243S, V245E, E248D, A272P, T286A, I293V, P294PS, E297K, G333E, Q334NB
 CA22066CA51041FJ983491D4T, 3TCNoneM184V T27S, T39A, S48E, I142V, S162SN, K166R, I178L, I195L, T200E, D250DE, A272P, K275R, K277R, T286TA, P294T, E297K, G333E, Q334HB
Ferreira (2010)p014Dip014GQ862324AZTNone  V60I, R83K, D123E, I135T, K173E, Q174K, D177E, R211Q, A272P, K277R, T286A, V292I, G333EB
von Wyl (2010)47968954796895GQ848133AZT, 3TCNoneM184V V118I, D123N, D177E, F214L, A272P, I293V, E297K, K311R, G333E, F346Y, G359S, A371V, A376T, K390KR, E399EDB