Reverse Transcriptase Inhibitors

HOME Genotype-Rx Genotype-Pheno Genotype-Clinical hivdb program

Reverse Transcriptase Inhibitors

Subtype	B
Gene	RT
Mutation	G333E
Rx	>= 1 NRTI (but no NNRTI)
IncludeMixtures	No

References	18
Patients	62
Isolates	67

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	NRTIs	NNRTIs	NRTIDRMs	NNRTIDRMs	OtherMut	Subtype
Lin (1994)	PFL-011	PFL011B		AZT	None			R83K, R211K, A272P, K277R, E297K, I329L, G333E, F346Y, A376T, T386I, E399D, A400T, D460N, S468P, S519N	B
		PFL011W78		AZT, D4T	None			R83K, R211K, Q242L, A272P, K277R, E297K, D324E, I329L, G333E, F346Y, V365I, A376T, T386I, E399D, A400T, D460N, V466I, S468P, H483Y, S519N	B
Hammer (1997)	ACTG320_1000	1000		AZT, DDI, D4T	None	M41L, D67N, K70R, L74I, T215FY, K219Q		V35I, E44ED, I50V, D123E, D177E, I178IM, E203D, V245T, A272P, K277R, P294T, E297R, G333E, Q334HY, R356K, G359GS, V365VI, T377S, K390R, T403AV, K431T, L452M, T470S, L486X	B
	ACTG320_1031	1031		AZT, DDI	None	D67N, K70R, T215F, K219Q		K20KR, D123E, I135T, G196E, Q207E, R211K, V245K, T286A, I293V, D324E, G333E, R358RK, D364E, T377R, T403V, E404D, Y405H, N418S, V435I, R461K, L469I, T470P	B
	ACTG320_1131	1131		AZT, DDC	None	T215CY		K20KR, D123E, I142V, S162C, Q197E, R211K, K277R, I293V, G333E, P345Q, G359GS, A371AV, T386I, K390R, E396D, A400T, D460N, R461K, S468T, Q487X	B
	ACTG320_115	115		AZT, DDC	None	M41L, T69D, L210W, T215Y		T39A, E44D, V118I, K122KE, S162T, E203K, Q207A, H208Y, R211K, K223E, L228R, A272P, K277R, G333E, G359S, V365I, A376S, T386I	B
	ACTG320_1162	1162		AZT, DDC	None	M41L, L210LW, T215Y		R83RK, K122Q, D177E, T200A, Q207QR, R211RK, A272P, T286A, I293IV, E297K, G333E, Q334L	B
	ACTG320_1166	1166		AZT	None			K20R, R211RK, K277R, I293IV, K311KR, P313T, Y319F, G333E, Q334H, T386I, A400T, Y405H, V435A, L452LI	B
	ACTG320_1198	1198		AZT, DDI	None	M41L, L74LV, T215D	Y181YC	V35VI, E44ED, R83RK, I135IT, I195L, V245VM, E297K, I329L, G333E, Q334H, R356RK, M357V, A376T, K390R, A400T, D460N	B
	ACTG320_1412	1412		DDC, AZT	None	M41L, D67N, K70R, L210W, T215Y		T39A, V60I, W88C, D123DE, I178IM, G196E, E203D, H208HY, R211K, A272P, I293V, L295Q, T296S, E297K, I329L, G333E, Q334H, M357T, G359S, V365I, K390R, A400T, Q428E, V435I, E449D, D460N, H483Y	B
	ACTG320_1729	1729		DDC, AZT, D4T	None	D67N, K70R, T215Y, K219Q		V60VI, T200I, Q207E, R211K, V245R, K277R, T286A, I293V, E297K, I329L, G333E, M357I, R358K, E370D, K390KR, Q394H, A400T	B
	ACTG320_1736	1736		AZT	None			K122KE, S162A, V245X, E248ED, D250DE, S251SN, A272P, I293V, G333E, Q334H, G359S, I375V, A376S, T377M, T386TI, T403M, E432D, V435VI, A446S	B
	ACTG320_1853	1853		AZT, D4T	None			I142V, T200I, R211K, V245VE, E248ED, K249Q, A272S, T286A, K311R, S322A, G333E, R356K, A360AT, A376V, K385R, K390R, A400T, V435E, A437V, V458I	B
	ACTG320_2113	2113		AZT, DDI	None	D67N, T69TADN, K70KR, T215F, K219Q		K20R, T39A, A98S, V106I, V118VI, K122Q, I135IV, I178L, F214L, L228H, V245T, K277R, T286A, E297K, G333E, M357T, G359S, K366R, A376T, T386I, K390R, A400T, K431T, K451R, L452LS, D460N, R461K, V467VI, H483Y, L486X	B
	ACTG320_2337	2337		AZT, DDI	None	M41L, D67N, T69D, L210W, T215Y, K219N		K20R, V35E, T39A, E40F, K43E, V118I, K122KE, E138G, I142T, S162C, G196E, Q207E, R211K, V245VE, A272P, K277R, I293V, E297A, G333E	B
	ACTG320_2339	2339		AZT, DDI	None	D67N, K70R, T215F, K219Q		K64KN, D121DN, E203ED, R211K, D218DE, A272P, T286A, A288AG, I293IV, E297K, K311R, I326V, G333E, Q334I, M357MT, K366KR, T369AV, A371V, I375V, A376T, T377TIM, K390R, A400T, T419TI, V435VAIT, D460N, R461K, S468T, H483Y	B
	ACTG320_2516	2516		AZT, DDI, D4T	None	D67G, K70R, K219Q		V35M, S68G, D177DE, I178M, G196GE, I202IV, Q207H, R211K, A272P, K277R, T286TA, E297K, E312EA, V317A, D324P, I329V, G333E, G335S, V365I, A376S, T386I, D460N, L469F	B
	ACTG320_2555	2555		AZT, DDC	None	D67DGNS, K70R, T215F, K219Q		S68SG, T69TN, D121Y, K122E, D177E, I178L, Q197P, Q207QE, A272P, K277R, G333E, G335S, R356K, A360T, K390R, V435M, D460DN, R461K	B
	ACTG320_2648	2648		AZT, DDI, DDC, D4T, 3TC	None	M41L, A62V, D67E, L210W, T215Y		K43Q, I50IV, S68MV, W88C, V118I, K122E, S162SG, N175Y, R211K, A272P, K277R, I293IV, I329V, G333E, G359S, A371V, A376T, A400T, K451KR, D460N, Q487X	B
	ACTG320_271	271		AZT, DDI	None	M41ML, D67N, K70R, T215Y		R83RK, S162CW, I178L, V245E, A272P, K277R, P294PS, E297K, L301LI, G333E, Q334HY, M357MV, A360AV, A400T, L452LS, D460N, Q480X	B
	ACTG320_2779	2779		AZT	None	D67DN, K70R, T215Y, K219KQ		D123E, D177E, Q197QP, Q207E, R211K, F214L, T286A, V292I, I293V, E297K, G333E, Q334H, T338S, A360AT, T377L, K390R, I393IM, A400T, V435I, D460N	B
	ACTG320_3611	3611		DDI, AZT	None			E6D, T27TP, S68SN, K102KR, G196GE, Q207T, L210ST, V245T, E248DN, I293V, K311R, I326V, G333E, Q334H, R356RK, M357MI, R358RK, T377R, T386I, A400T, Y405YH, K431T, V435VA, V466A, H483Y, D488X	B
	ACTG320_376	376		AZT	None	M41L, T215Y		V35VIM, R211K, A272P, I293V, G333E, Q334N, R356RK, G359GS, A371AV, T386I, K390R, A400I, D460N, R461K, S468C, Q480X	B
	ACTG320_3968	3968		AZT, DDC	None	M41L, D67N, T69D, L210W, T215Y		K22KN, E28A, V35L, E44ED, R83K, K104N, V118VI, K122KE, S162SG, I178L, H208HY, R211RK, A272P, K277R, E297K, K311R, G333E, Q334H, R356K, K366R, T386I, A400T, V435I, D460N, Q480X	B
	ACTG320_546	546		AZT, DDI	None	F77FL, F116FY, Q151M, K219KE		K49R, E53D, L205LF, R211K, A272P, K277R, I293V, E297R, L301I, I329IV, G333E, Q334H, I375V, T377TI, E404D, S468P, T470A	B
	ACTG320_706	706		AZT, DDC, D4T	None	D67N, K70R, T215TFIS, K219Q		V35M, T39TA, K64KN, K103KR, K122KE, I178IM, E203K, E248V, A272P, E297K, I329L, G333E, R358K, A376T, K390R, A400T, V435I, D460S, H483Y, L491X	B
	ACTG320_763	763		DDI, AZT, D4T	None	D67N, T69D, K70R, T215F, K219Q		K20R, V35L, K104R, I135V, K173E, Q207E, R211RK, L283I, R284K, I293V, P294T, G333E, Q334H, R356RK, A360T, V365I, I380V, T386I, K390R, I393M, S468T, L469I, T470A	B
	ACTG320_795	795		AZT	None	K70R		K11KQ, V35I, T39A, S48T, K104N, V245M, A272P, T286A, V292VI, I293IV, T296TS, E297K, V317VA, G333E, Q334H, A360T, Q367L, I375V, T403M, S468P	B
	ACTG320_969	969		AZT, DDI	None	L74LV, T215TADN		K122E, Q174H, D177DG, I178IL, Q207QK, H208HY, R211K, V245M, A272P, E297K, I329L, G333E, Q334CHRY, R356K, A360T, A400T, V435T, L452LS, D460N, T470TA	B
	ACTG320_978	978		AZT, DDI	None			T39TA, A98S, K122KE, I135RT, K173N, Q207QH, R211K, F214L, V245VM, L283I, I293V, E297A, K311R, G333E, Q334H, M357T, T377K, K390R, E404D, L452I, L469I, T470TN, L486X	B
Coakley (2000)	EC15	EC15F		D4T, DDI	None			Q207E, R211K, V245M, I293V, E312N, I326V, I329V, G333E, M357T, A376S, V381I, K390R, K395R, D460N, R461K, V467I, L469I, L491S, A554T, K558R	B
	EC24	EC24F		D4T, DDI	None			S162C, Q207E, R211K, V245M, I293V, E312N, I329V, G333E, M357T, T369P, A376S, K390R, T397P, D460N, R461K, V467I, L491S, T497P, K512R, A554T, K558R	B
		EC24PF		D4T, DDI	None	D67N		A158S, Q207E, V245M, W266R, E312N, I329V, G333E, E344G, M357T, A376P, V381I, K390R, P421S, L425I, D460DN, S468PT, H483HY, K512KQ, S519SN	B
	EC26	EC26F		D4T, DDI	None	V75T	V179D	D123E, D177E, V245M, A272S, K277R, I293V, G333E, Q334H, T338S, M357I, T377L, A400T, T470N, K512I, E516K, V548I	B
Bacheler (2001)	DMP003-28	03-28000	AF349335	NRTI	None	M184V		E28EG, K122E, D123E, S162C, D177E, T200TA, Q207E, R211K, V245VI, A272P, K277R, Q278N, T286A, I293V, D324E, G333E, R358K, G359S, K390R, A400X	B
	DMP003-94	03-94242B	AF349369	NRTI	None	M41L, T215D		V60I, R83K, R211K, A272P, I293V, G333E, Q334Y, M357T, K390R	B
	DMP004-143	04-143000B	AF349400	AZT, 3TC	None	M184V		V35R, K49R, V60I, K166I, D177E, I178M, T200A, Q207E, A272P, T286A, E297K, G333E, Q334Y, M357T, G359GS, E370D, K390R	B
Gonzales (2001)	CA1825	CA4911	AY030738	AZT, DDI, D4T, 3TC	None	M41L, M184V, L210W, T215Y		E28EG, K43Q, V118I, K122KE, Q174R, I178IM, Q207E, R211K, A272P, E291D, A304G, E305GR, N306X, G333E, Q334H, T338S, K390R, A400T, T403TM, D460N, V467VI, S519N, E529D, K530KR, I556V, K558R	B
	CA2256	CA9177	AY030842	AZT, DDC, 3TC, D4T	None	M41L, L210W, T215Y		K11R, V35I, K43N, E44ED, R83K, G196E, T200A, Q207E, H208HY, R211K, L228HR, V245E, A272P, K277R, Q278H, T286A, E297R, G333E, R358RK, A360AT, A400L, E404N, N418S, L452A, D460N, H483Y, A554S	B
	CA6495	CA16029	AY032446	AZT, DDI, D4T, 3TC, DDC	None	D67N, T69D, K70R, M184V, K219Q		K20R, T39A, K82KR, I135V, E169D, Q174N, F214L, L228H, A272P, I293V, T296S, I309IT, K311R, D324E, G333E, Q334H, R356K, M357I, A360T, T369A, K374R, A376N, E404D, L469I, T470P, D471DE, K476KR, S519N, A554T	B
Kempf (2001)	DK-6273	DK-6273		NRTI	None	M41L, D67N, K70R, L210W, T215Y, K219H		I5V, E6D, K20R, E44D, V60I, V118I, D123E, D177E, G196E, T200I, E203D, Q207E, H208Y, R211K, L228H, T286A, I293V, E297K, I329V, G333E, Q334Y, M357T, E399D	B
Gibb (2002)	DMG57	57_w38		ABC, 3TC	None			V35IM, V60VI, R83EK, K103KR, D123E, F130FC, I178IM, G196E, R211K, A272P, K281R, A288S, I293IV, E297K, I329L, G333E, M357T, K366KR, T369V, I375IV, A376T, K390R	B
Maxeiner (2002)	380686f	380686fpre		AZT	None			S162C, Q207E, A272P, K277R, T286A, T296S, E297K, I329L, G333E, G335S, A360T, T386I, A400T, V435I, L452A, D460N, R461K, S468H, S519N	B
		380686f+		AZT, D4T	None			S162C, Q207E, V245VA, A272P, K277R, T286A, T296S, E297K, I329L, G333E, G335S, A360T, T386I, A400T, Y405YH, V435I, L452A, D460N, R461K, S468H, S519N	B
	501229e	501229e+		D4T	None			T27TS, R83K, K173N, Q174K, I178L, T200A, V245E, A272P, K277KR, V292I, E297K, G333E, Q334H, V365I, A376T, K390R, V435VA, D460N, L469LI, L491LS, A554NS, K558R	B
Gonzales (2003)	CA1825	CA16946	AF514119	AZT, DDI, D4T, 3TC	None	M41L, M184V, L210W, T215Y		K43Q, S68G, V118I, K122KE, I135IV, Q174R, T200A, Q207E, R211RK, E224ED, A272P, E291D, D324E, G333E, Q334H, T338S, K390R, A400T, T403TM, D460N, V466VI, V467VI, T470TP, L491LS, S519N, Q524QE, E529D, K530R, I556V, K558R	B
Dumans (2004)	RG034	RG034	AY390208	AZT, 3TC	None	D67N, K70R, M184V, L210LW, T215Y, K219KQ		K30R, K122E, I135T, E169D, I202V, Q207E, R211K, A272P, K277R, V292I, I293V, E297A, K311R, V317A, I329V, G333E, Q334L	B
Gulick (2004)	RG165	RG165w130		ABC, AZT, 3TC, D4T	None	M184V		E6K, S48T, D123E, I135V, D177E, I178M, T200A, V245T, A272P, K277R, T286A, E297K, L310I, S322A, G333E, Q334H, W337W*, K366R, A376V, T386I	B
Non-B Workgroup (2005)	BR7	BR7		AZT, 3TC	None	D67N, K70R, M184V, L210LW, T215Y, K219KQ		K30R, K122E, I135T, E169D, I202V, Q207E, R211K, A272P, K277R, V292I, I293V, E297A, K311R, V317A, I329V, G333E, Q334L	B
Rhee (2005)	CA3888	CA34583	AY801184	D4T, DDI	None	D67N, K70E, V75T		K11A, V35T, D86E, V106I, I135V, I142V, G196E, Q197K, Q207E, A272P, I293V, E297V, G333E, Q334H, M357I, A376T, T386I, V435E, D460N, R461K, L469I, L491S, L517I, S519N, Q520K, K527N, A534T	B
	CA7884	CA19929	AY801812	AZT, D4T, DDI	None	F77FL, Q151M, N348I		K22KR, R83RK, K166R, T200A, F214L, A272P, K277R, Q278QE, T286A, I293V, P294S, E297A, G333E, Q334H, I341F, K366R, A376AT, T386TI, A400T, T470A, H483Y, E516D, S519N, Q520N, K527N, K530R, A554S	B
	CA8411	CA41331	AY802005	3TC, D4T	None	T215TS		V35I, S162C, R211K, V245VE, A272P, K277R, I293V, V317A, G333E, Q334H	B
	CA14611	CA48210	AY802390	AZT, 3TC	None	M41L, M184V, L210W, T215Y		K43Q, S68G, K122E, K166R, T200I, R211K, A272P, I293V, G333E	B
	CA16323	CA41397	AY802477	DDC, AZT, D4T, 3TC	None			E6EK, K122E, D123E, I142IT, D177E, I178M, R211S, A272AP, K277R, T286A, V292VI, I293V, E297A, G333E, T338S	B
	CA16329	CA42770	AY802481	AZT, 3TC, ABC	None	M41L, D67N, M184V, L210W, T215Y		K43KDEN, E44D, V111I, V118VI, D123E, S162F, I178L, V189VI, G196E, T200A, E203D, H208F, R211KN, A272P, K277R, A288AT, I293V, E297A, G333E, P345Q	B
		CA42772	AY802482	AZT, 3TC, ABC	None	M41L, D67N, M184V, L210W, T215Y		K43KDEN, E44D, V111I, V118VI, D123E, S162F, I178L, V189VI, G196E, T200A, E203D, H208F, R211KN, A272P, K277R, A288AT, I293V, E297A, G333E	B
Riddler (2008)	RG25563	RG25563w11		AZT, 3TC	None			E6ED, K11KT, V35I, R83K, Q197P, T200AE, Q207E, R211K, V245E, K277R, I293V, E297R, K311KR, G333E, Q334H, R356RK, K366R, K390R, E399ED, A400AT	B
	RG31923	RG31923w67		AZT, 3TC	None	M184V		K20R, V60I, K64R, Q174N, A272P, K277R, T286V, V292I, E297R, K311R, I326V, G333E, R356K, R358K, Q373H, K390R	B
	RG41688	RG41688w13		AZT, 3TC	None			E6D, K20R, V60I, R83K, D123E, T200I, R211RK, A272P, K281R, T286A, E297K, K311R, D324E, G333E, Q334N, A360V, Q373N, K390R	B
	RG56208	RG56208w11		TDF, 3TC	None			K104KR, K122E, D123N, K173E, I178M, V245E, E248D, A272P, I293V, K311R, G333E, Q334C, G359S, K385R, K390R	B
	RG60519	RG60519w24		AZT, 3TC	None		V179VDIN	K20R, D121C, K122E, A158S, S163ST, T165I, K166KR, E169ED, D177E, R211K, F214L, V245N, A272P, K277R, V292I, I293IV, E297K, V317A, G333E, Q334H, P345Q, M357T, T386TN	B
	RG66956	RG66956w138		AZT, 3TC	None			V60VI, S68G, R83K, D123E, S162C, T200TA, Q207HN, R211K, L228H, K277R, T286A, A288S, I293IV, E297K, G333E, T338S, V381VI, K390R	B
Rosen-Zvi (2008)	75	02p75-1		AZT, DDC, 3TC, D4T, DDI	None	M184V		E6EK, V35VI, R83K, K102R, R211K, K277R, T286A, E297K, G333E	B
Rhee (2009)	CA17695	CA41633	FJ983454	D4T, 3TC	None	M184V		V35I, R83K, K122KE, I178L, Q207E, R211K, P243S, V245E, E248D, A272P, T286A, I293V, P294PS, E297K, G333E, Q334N	B
	CA22066	CA51041	FJ983491	D4T, 3TC	None	M184V		T27S, T39A, S48E, I142V, S162SN, K166R, I178L, I195L, T200E, D250DE, A272P, K275R, K277R, T286TA, P294T, E297K, G333E, Q334H	B
Ferreira (2010)	p014	Dip014	GQ862324	AZT	None			V60I, R83K, D123E, I135T, K173E, Q174K, D177E, R211Q, A272P, K277R, T286A, V292I, G333E	B
von Wyl (2010)	4796895	4796895	GQ848133	AZT, 3TC	None	M184V		V118I, D123N, D177E, F214L, A272P, I293V, E297K, K311R, G333E, F346Y, G359S, A371V, A376T, K390KR, E399ED	B

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