Reverse Transcriptase Inhibitors

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Reverse Transcriptase Inhibitors

Subtype	B
Gene	RT
Mutation	G333D
Rx	RTI-naive
IncludeMixtures	No

References	23
Patients	44
Isolates	46

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	NRTIs	NNRTIs	NNRTIDRMs	OtherMut	Subtype
Coakley (2000)	EC36	EC36B		None	None		R211K, V245M, A272P, K277R, I293V, E297K, G333D, R356K, T377A, S468P, H483N	B
Carr (2001)	ARMS008	ARMS008	AY037269	None	None		V21I, Q174H, I178M, Q207E, R211K, V245M, A272P, I293V, I326V, I329V, G333D, Q334N, T386V, T403M, L452I, S468P, T470K, S519N	B
Lama (2006)	Pt3117	3117		None	None		V35VI, E53D, V60I, R83K, D121Y, K122E, I135T, K173S, Q174K, T200A, R211K, A272P, I293V, P294S, E297K, S322*, G333D	B
Margot (2006)	7225	7225BL		None	None		D123E, K173E, D177E, I178M, T200A, E204K, Q207A, R211K, P243T, E297A, L301M, I326IV, G333D, Q334N, T377L, T386I, K390R	B
	7626	7626BL		None	None		V35I, K82R, R83K, D123E, I180V, T200A, K281KR, T286A, I293IV, E297K, G333D, K390R	B
Pando (2006)	04AR151516	04AR151516	DQ383752	None	None		D121Y, K122E, I135T, I202V, Q207K, R211K, A272G, T286A, A288S, I293V, E297K, G333D, R356RK, Q373N, S379G, T386I, K390R, E399D, T403M, V435A, K454R, L517I, K530R, A554S	B
Brumme (2007)	1583	PRRT_1583	EF368893	None	None		V35I, S117L, K122Q, K166R, D177E, I178M, G196E, Q207E, V245I, A272P, K277R, I293V, E297A, G333D	B
Dilernia (2007)	F162	F162	EF120150	None	None	V179D	K20R, K32N, K49R, V60I, K101Q, K122KE, I135K, E169D, D177E, G196E, T200A, V245M, E248X, A272P, K277R, I293V, P294Q, K311R, D324E, I329L, G333D, K366R, A376AS, T386I, K390R	B
Holguin (2007)	595888	595888	EF583220	None	None		R83K, K122E, A158AS, S162C, I178L, Q207K, R211K, A272P, I293V, E297A, K311R, G333D	B
	597057	597057	EF583224	None	None		K22R, K49R, K122E, I135L, I142T, N175H, V179A, Q197P, R211K, A272P, T286A, T296S, G333D, Q334H	B
Sanchez Onoro (2007)	595888	595888		None	None		R83K, K122E, A158AS, S162C, I178L, Q207K, R211K, A272P, I293V, E297A, K311R, G333D	B
	597057	597057		None	None		K22R, K49R, K122E, I135L, I142T, N175H, V179A, Q197P, R211K, A272P, T286A, T296S, G333D, Q334H	B
	720501	720501		None	None		K22R, K49R, K122E, D123DN, I135L, I142T, N175H, V179A, Q197P, R211K, A272P, K277R, T286A, T296S, Y319Y*, G333D, Q334H	B
Bang (2008)	025	BJH_025	EF157881	None	None		V35L, V118I, K122E, I135R, G196E, T200M, E204K, Q207E, F214L, I293V, G333D	B
	039	BJH_039	EF157895	None	None		E6K, K103KR, V118I, K122E, T139A, G196E, T200K, K201R, Q207DE, F214L, V245K, I270ILRS, K275ILR, I293V, G333D, Q334H	B
Holguin (2008)	SP58-275600	SP58-275600	EU255361	None	None	Y181YC, G190S	K20R, V35I, V60I, K122KE, E248N, D250E, A272P, A288S, P294T, G333D	B
	SP33-302390	SP33-302390	EU255406	None	None		V35I, S68G, D123E, I135T, I195L, T200A, R211T, A272P, T286A, A288AT, E297R, K311R, S322T, I329IV, G333D, Q334N	B
Miura (2008)	BEC51	BEC51	EU517989	None	None		R83RK, I135V, I195T, T200TA, V245M, V276I, T286A, I293V, K323R, G333D, A360T, K390R, K431KR, D460N, R461K, L491S, E516V	B
Brumme (2009)	R0500	R0500	GQ372121	None	None		P1PS, K64R, K104R, K122E, D123E, I135V, T139A, K173E, T200A, I202V, E248D, D250N, A272P, I293V, E302EG, G333D, Q334H, M357T, A376S, T377L, K390R, A400I, V435I, A446S, D460N, R461K, S468T, L491S, I506L, S519N, A534S	B
	R4543	R4543	GQ372133	None	None		V35I, T39S, R83K, V118I, D121H, K122E, K173E, D177E, I178L, R211K, F214L, A272P, K277R, I293V, I329V, G333D, Q334H, M357S, T369A, K390R, A400T, V435I, H483HY, L491LS, A502S, S519N, Q520QK, K527N, A554T	B
	R6526	R6526	GQ372137	None	None		K11R, D86E, D123E, I135V, S162C, Q174H, R211K, A272P, I293V, E297R, G333D, R356K, T377L, K385R, K390R, A400S, T403M, E404N, V435I, L452S, K454R, R461K, T470A, T472TS, Q524E, V531VA	B
	S2513	S2513	GQ372153	None	None		V60I, K173T, D177E, R211K, V245M, V254I, A272P, K277R, T286A, I293V, E297K, D324E, G333D, Q334C, R356K, M357V, I375V, K390R, A400T, K431R, V435A, D460S, S468T, T470N, H483N, A554T	B
	PRRT_4099	PRRT_4099	GQ303788	None	None		V106I, D123DN, I135T, S162C, I178ILM, E204D, R211K, K277R, A288S, I293V, E297A, G333D, A376T, T386I, K390R, E399D, A400T, E432ED, K454R, K558R	B
Cuevas (2009)	X2629_1	X2629_1	GU326156	None	None		K122R, D123E, S162C, R172K, D177E, I178M, I180L, E194K, A272P, K277R, I293V, G333D	B
Vercauteren (2009)	pt1839	2261924615	GQ399185	None	None		I135V, S162C, Q174H, R211G, T286A, I293V, V317A, D324DE, I329L, G333D	B
	pt1450	4558440144	GQ399574	None	None	V179D	K20R, T200I, V245E, K277R, A288S, V292I, I293V, P294T, I326V, G333D	B
	pt1152	6256491241	GQ399872	None	None		V35I, K49R, R83K, K122PQ, I135T, I142L, E169D, R211K, V245VE, D250DE, A272P, K277R, E291D, K311KR, S322T, D324DE, G333D	B
	pt1084	6700072556	GQ399940	None	None		V21I, D86DE, K102KQ, I135V, S162C, T286A, I293V, E297R, G333D	B
	pt856	8015329067	GQ400168	None	None		I135T, Q174H, A272P, L283I, P294Q, E297D, G333D	B
Bonura (2010)	1024_97	1024_97	GU969481	None	None		E6K, K122E, D123E, I142IV, S162C, G196E, T200A, I202V, L210LS, R211G, A272P, V276T, K277R, L283LI, P294T, E297R, G333D	B
Brennan (2010)	Pat137	ARC-A94	JN697242	None	None		V118I, D123E, A158AS, T165TI, K166R, I178M, Q207E, R211K, F214L, A272P, K277R, I293V, G333D, Q334H	B
	Pat062	ARC-A176	JN697317	None	None		P4S, R83K, S162A, R211K, V245MT, E248N, D250E, A272P, T286A, I293V, L295F, E297K, G333D	B
Descamps (2010)	238odyssee	238odyssee	HQ718071	None	None		K20R, V60I, V118I, I135R, E169D, Q207E, R211K, F214L, V245Q, A272P, T286A, V317A, I329L, G333D	B
Yebra (2010)	173819	05SP0173819	FJ481795	None	None		V35I, R83K, I178M, T200I, E204T, Q207D, R211K, A272P, T286A, E297Q, S322T, G333D, Q334H	B
	243933	05SP0243933	FJ481801	None	None		V60I, V90I, K102Q, I135T, E138A, I142V, T165I, I178M, I202V, R211K, F214L, A272P, K277R, P294Q, P313AT, P321PS, D324E, I329L, G333D	B
Santos (2011)	J350	J350_PR_RT_CN	JN010733	None	None		S134C, I135P, D177E, T200A, Q207N, R211K, A272P, A288S, E297K, E300D, G333D, V365I, A376T, T386L, K390R, E399D, L452A	B
Avila-Rios (2012)	M18CMB9HSU	M18CMB9HSU	KC169248	None	None		K103R, D123E, D177E, V179I, R211K, A272P, V276I, T286A, V317A, I329V, G333D	B
	D170M85MKE	D170M85MKE	KC168371	None	None		E204EQ, R211K, F214L, V245T, A272P, P294T, E297D, G333D	B
	D270ME0PSE	D270ME0PSE	KC168407	None	None		V35L, I50V, K122P, I135IV, T139TK, P140T, Q174K, D177E, Q207NS, R211K, K219KT, A272P, K277R, E297K, D324E, G333D	B
	D700MB4MTY	D700MB4MTY	KC168427	None	None		K20KR, K64R, D121H, K122E, I135T, K173E, Q174H, D177E, I178L, R211K, K238R, A272P, K277KR, G333D, Q334H	B
	D800MG1UU5	D800MG1UU5	KC168434	None	None		V35M, T39A, R83K, D123E, R211K, A272P, K281KR, T286A, A288G, I293IV, E297K, L310I, S322T, D324DE, I329L, G333D, Q334N	B
	B700MD7IS5	B700MD7IS5	KC168147	None	None		K20R, K122E, I135V, S162C, T200A, R211K, V245K, T286A, A288S, I293V, E297K, G333D	B
	E700M8ADPS	E700M8ADPS	KC168742	None	None		V60VI, D123E, I135IR, D177E, I178M, A272P, K275KR, V276VI, K277R, I293V, G333D	B
	E8C0MA2LZ9	E8C0MA2LZ9	KC168759	None	None		E79D, K102Q, K103R, K122KE, K173R, D177E, T200TA, I202V, R211K, A272APS, T286A, A288S, I293V, E297R, L301I, G333D, Q334H	B
Machado (2012)	CUPL1087	CUPL1087	JN000059	None	None		A98S, K122E, I135M, S162C, D177E, I178M, R211K, F214L, K220Y, K223I, L228H, V245E, D250E, A272P, K277R, T286A, E297T, I329V, G333D, K350R, R358K, G359N, A376S, V381I, K390R	B
Tramuto (2013)	CV1320_102	CV1320_102	HQ667697	None	None		V35I, V106I, K122E, I142IM, S162ST, K166KR, I178M, Q197P, A272P, E297A, S322T, I329V, G333D	B

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