<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype B
Gene RT
Mutation G333D
Rx RTI-naive
IncludeMixtures No
References 34
Patients 79
Isolates 81
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Coakley (2000)EC36EC36B NoneNone  R211K, V245M, A272P, K277R, I293V, E297K, G333D, R356K, T377A, S468P, H483NB
Carr (2001)ARMS008ARMS008AY037269NoneNone  V21I, Q174H, I178M, Q207E, R211K, V245M, A272P, I293V, I326V, I329V, G333D, Q334N, T386V, T403M, L452I, S468P, T470K, S519NB
Lama (2006)Pt31173117 NoneNone  V35VI, E53D, V60I, R83K, D121Y, K122E, I135T, K173S, Q174K, T200A, R211K, A272P, I293V, P294S, E297K, S322*, G333DB
Margot (2006)72257225BL NoneNone  D123E, K173E, D177E, I178M, T200A, E204K, Q207A, R211K, P243T, E297A, L301M, I326IV, G333D, Q334N, T377L, T386I, K390RB
 76267626BL NoneNone  V35I, K82R, R83K, D123E, I180V, T200A, K281KR, T286A, I293IV, E297K, G333D, K390RB
Pando (2006)04AR15151604AR151516DQ383752NoneNone  D121Y, K122E, I135T, I202V, Q207K, R211K, A272G, T286A, A288S, I293V, E297K, G333D, R356RK, Q373N, S379G, T386I, K390R, E399D, T403M, V435A, K454R, L517I, K530R, A554SB
Brumme (2007)1583PRRT_1583EF368893NoneNone  V35I, S117L, K122Q, K166R, D177E, I178M, G196E, Q207E, V245I, A272P, K277R, I293V, E297A, G333DB
Dilernia (2007)F162F162EF120150NoneNone V179DK20R, K32N, K49R, V60I, K101Q, K122KE, I135K, E169D, D177E, G196E, T200A, V245M, E248X, A272P, K277R, I293V, P294Q, K311R, D324E, I329L, G333D, K366R, A376AS, T386I, K390RB
Holguin (2007)595888595888EF583220NoneNone  R83K, K122E, A158AS, S162C, I178L, Q207K, R211K, A272P, I293V, E297A, K311R, G333DB
 597057597057EF583224NoneNone  K22R, K49R, K122E, I135L, I142T, N175H, V179A, Q197P, R211K, A272P, T286A, T296S, G333D, Q334HB
Sanchez Onoro (2007)595888595888 NoneNone  R83K, K122E, A158AS, S162C, I178L, Q207K, R211K, A272P, I293V, E297A, K311R, G333DB
 597057597057 NoneNone  K22R, K49R, K122E, I135L, I142T, N175H, V179A, Q197P, R211K, A272P, T286A, T296S, G333D, Q334HB
 720501720501 NoneNone  K22R, K49R, K122E, D123DN, I135L, I142T, N175H, V179A, Q197P, R211K, A272P, K277R, T286A, T296S, Y319Y*, G333D, Q334HB
Bang (2008)025BJH_025EF157881NoneNone  V35L, V118I, K122E, I135R, G196E, T200M, E204K, Q207E, F214L, I293V, G333DB
 039BJH_039EF157895NoneNone  E6K, K103KR, V118I, K122E, T139A, G196E, T200K, K201R, Q207DE, F214L, V245K, I270ILRS, K275ILR, I293V, G333D, Q334HB
Holguin (2008)SP58-275600SP58-275600EU255361NoneNone Y181YC, G190SK20R, V35I, V60I, K122KE, E248N, D250E, A272P, A288S, P294T, G333DB
 SP33-302390SP33-302390EU255406NoneNone  V35I, S68G, D123E, I135T, I195L, T200A, R211T, A272P, T286A, A288AT, E297R, K311R, S322T, I329IV, G333D, Q334NB
Miura (2008)BEC51BEC51EU517989NoneNone  R83RK, I135V, I195T, T200TA, V245M, V276I, T286A, I293V, K323R, G333D, A360T, K390R, K431KR, D460N, R461K, L491S, E516VB
Brumme (2009)R0500R0500GQ372121NoneNone  P1PS, K64R, K104R, K122E, D123E, I135V, T139A, K173E, T200A, I202V, E248D, D250N, A272P, I293V, E302EG, G333D, Q334H, M357T, A376S, T377L, K390R, A400I, V435I, A446S, D460N, R461K, S468T, L491S, I506L, S519N, A534SB
 R4543R4543GQ372133NoneNone  V35I, T39S, R83K, V118I, D121H, K122E, K173E, D177E, I178L, R211K, F214L, A272P, K277R, I293V, I329V, G333D, Q334H, M357S, T369A, K390R, A400T, V435I, H483HY, L491LS, A502S, S519N, Q520QK, K527N, A554TB
 R6526R6526GQ372137NoneNone  K11R, D86E, D123E, I135V, S162C, Q174H, R211K, A272P, I293V, E297R, G333D, R356K, T377L, K385R, K390R, A400S, T403M, E404N, V435I, L452S, K454R, R461K, T470A, T472TS, Q524E, V531VAB
 S2513S2513GQ372153NoneNone  V60I, K173T, D177E, R211K, V245M, V254I, A272P, K277R, T286A, I293V, E297K, D324E, G333D, Q334C, R356K, M357V, I375V, K390R, A400T, K431R, V435A, D460S, S468T, T470N, H483N, A554TB
 PRRT_4099PRRT_4099GQ303788NoneNone  V106I, D123DN, I135T, S162C, I178ILM, E204D, R211K, K277R, A288S, I293V, E297A, G333D, A376T, T386I, K390R, E399D, A400T, E432ED, K454R, K558RB
Cuevas (2009)X2629_1X2629_1GU326156NoneNone  K122R, D123E, S162C, R172K, D177E, I178M, I180L, E194K, A272P, K277R, I293V, G333DB
Vercauteren (2009)pt18392261924615GQ399185NoneNone  I135V, S162C, Q174H, R211G, T286A, I293V, V317A, D324DE, I329L, G333DB
 pt11526256491241GQ399872NoneNone  V35I, K49R, R83K, K122PQ, I135T, I142L, E169D, R211K, V245VE, D250DE, A272P, K277R, E291D, K311KR, S322T, D324DE, G333DB
 pt10846700072556GQ399940NoneNone  V21I, D86DE, K102KQ, I135V, S162C, T286A, I293V, E297R, G333DB
 pt8568015329067GQ400168NoneNone  I135T, Q174H, A272P, L283I, P294Q, E297D, G333DB
Bonura (2010)1024_971024_97GU969481NoneNone  E6K, K122E, D123E, I142IV, S162C, G196E, T200A, I202V, L210LS, R211G, A272P, V276T, K277R, L283LI, P294T, E297R, G333DB
Brennan (2010)Pat137ARC-A94JN697242NoneNone  V118I, D123E, A158AS, T165TI, K166R, I178M, Q207E, R211K, F214L, A272P, K277R, I293V, G333D, Q334HB
 Pat062ARC-A176JN697317NoneNone  P4S, R83K, S162A, R211K, V245MT, E248N, D250E, A272P, T286A, I293V, L295F, E297K, G333DB
Descamps (2010)238odyssee238odysseeHQ718071NoneNone  K20R, V60I, V118I, I135R, E169D, Q207E, R211K, F214L, V245Q, A272P, T286A, V317A, I329L, G333DB
Yebra (2010)17381905SP0173819FJ481795NoneNone  V35I, R83K, I178M, T200I, E204T, Q207D, R211K, A272P, T286A, E297Q, S322T, G333D, Q334HB
 24393305SP0243933FJ481801NoneNone  V60I, V90I, K102Q, I135T, E138A, I142V, T165I, I178M, I202V, R211K, F214L, A272P, K277R, P294Q, P313AT, P321PS, D324E, I329L, G333DB
Santos (2011)J350J350_PR_RT_CNJN010733NoneNone  S134C, I135P, D177E, T200A, Q207N, R211K, A272P, A288S, E297K, E300D, G333D, V365I, A376T, T386L, K390R, E399D, L452AB
Avila-Rios (2012)M18CMB9HSUM18CMB9HSUKC169248NoneNone  K103R, D123E, D177E, V179I, R211K, A272P, V276I, T286A, V317A, I329V, G333DB
 D170M85MKED170M85MKEKC168371NoneNone  E204EQ, R211K, F214L, V245T, A272P, P294T, E297D, G333DB
 D270ME0PSED270ME0PSEKC168407NoneNone  V35L, I50V, K122P, I135IV, T139TK, P140T, Q174K, D177E, Q207NS, R211K, K219KT, A272P, K277R, E297K, D324E, G333DB
 D700MB4MTYD700MB4MTYKC168427NoneNone  K20KR, K64R, D121H, K122E, I135T, K173E, Q174H, D177E, I178L, R211K, K238R, A272P, K277KR, G333D, Q334HB
 D800MG1UU5D800MG1UU5KC168434NoneNone  V35M, T39A, R83K, D123E, R211K, A272P, K281KR, T286A, A288G, I293IV, E297K, L310I, S322T, D324DE, I329L, G333D, Q334NB
 B700MD7IS5B700MD7IS5KC168147NoneNone  K20R, K122E, I135V, S162C, T200A, R211K, V245K, T286A, A288S, I293V, E297K, G333DB
 E700M8ADPSE700M8ADPSKC168742NoneNone  V60VI, D123E, I135IR, D177E, I178M, A272P, K275KR, V276VI, K277R, I293V, G333DB
 E8C0MA2LZ9E8C0MA2LZ9KC168759NoneNone  E79D, K102Q, K103R, K122KE, K173R, D177E, T200TA, I202V, R211K, A272APS, T286A, A288S, I293V, E297R, L301I, G333D, Q334HB
Betancor (2012)HCB-7052077953HCB-7052077953JX271333NoneNone  R83K, D121Y, K122E, I135IT, I142M, K166R, E169D, G196E, R211T, A272P, K277R, T286A, E297K, D324E, G333D, Q334HB
Lunar (2013)pt14504558440144GQ399574NoneNone V179DK20R, T200I, V245E, K277R, A288S, V292I, I293V, P294T, I326V, G333DB
Tramuto (2013)CV1320_102CV1320_102HQ667697NoneNone  V35I, V106I, K122E, I142IM, S162ST, K166KR, I178M, Q197P, A272P, E297A, S322T, I329V, G333DB
Chikata (2014)KI-681KI-681AB874033NoneNone  K20R, V35I, Q91QH, K122E, D123E, I135T, K166KR, D177E, I178M, T200TKN, R211X, A272P, I293V, P313T, V314I, G333D, Q334N, I375V, T386I, E396D, E432D, H483Y, Q509H, V531I, A554SB
Martin (2014)ACU21ACU21KJ869920NoneNone K103NV35I, R83K, D177E, G196E, K249Q, A272P, K311R, D324E, G333D, K366R, S379G, K390RB
Parczewski (2014)196_WR11196_WR11KM284029NoneNone  K49R, K102Q, V106I, I142IV, S162H, Q197K, E203D, E224ED, V245K, A272P, K277R, I293V, P294T, P321S, G333DB
 A034_1A034_1KM284518NoneNone  R83K, K102Q, S162H, E169D, T200A, R211K, V245K, A272P, K277R, K281R, T286TA, I293V, G333DB
 90_KR1390_KR13KM284470NoneNone  K20R, V60I, I135T, S162C, E169D, R172RK, Q207E, V245Q, A272P, K277R, T286A, V317A, I329L, G333DB
 446_KR12446_KR12KM284262NoneNone  K122E, I135T, S162C, E194N, G196Q, Q207A, R211K, V245Q, K277KR, T286A, A288S, V292VI, P294PT, E297R, K311R, D324E, G333DB
 241_WR13241_WR13KM284092NoneNone  S68G, V106I, S162H, T200TA, E203Q, R211G, E224D, V245N, A272P, K277R, I293V, P294T, G333DB
 253_BI13253_BI13KM284107NoneNone  K20R, K49KR, V60I, D123E, I135T, E169D, Q207E, R211K, V245Q, A272P, K277R, T286A, I329LV, G333DB
 403_BI12403_BI12KM284229NoneNone  K20R, V60I, D123E, E169D, D177E, Q207E, R211K, V245Q, A272P, T286A, D324E, I329L, G333DB
 210_WR13210_WR13KM284051NoneNone  S68G, V106I, S162H, D192N, T200A, R211A, E224D, V245E, A272P, K277R, I293V, P294T, P321S, G333DB
 523_PN12523_PN12KM284331NoneNone  K102Q, K103R, V106I, S162H, R211RK, V245E, A272P, K277R, I293V, P294T, E297K, P321S, G333DB
 151_PN11151_PN11KM283967NoneNone  K102Q, V106I, S162H, E224ED, V245D, A272P, K277R, I293V, P294T, P321S, G333DB
 300_WR11300_WR11KM284155NoneNone  K102Q, V106I, I142V, S162H, Q197K, E203D, V245K, A272P, K277R, I293V, P294T, P321S, G333DB
 352_KR12352_KR12KM284189NoneNone  V35I, S48E, V60I, V118I, D123E, T200A, R211K, F214L, E248D, A272P, I293V, P294T, E297Q, K311R, G333DB
 66_WR1366_WR13KM284420NoneNone  K49R, K102Q, V106I, S162Y, Q182QP, E203D, R211RK, E224ED, V245E, A272P, K277R, I293V, P294T, P321S, G333DB
Chin (2015)NMC20130602013060KM820351NoneNone  K20R, K22R, V118I, K122E, D123N, I135R, K166R, G196E, T200I, R211G, F214L, V245I, S251C, A272P, K277R, I293V, E297Q, G333DB
Hora (2015)DEMB09US002DEMB09US002JX140657NoneNone K103NP4S, V35I, K101R, I135L, S162C, D177E, I178M, D192N, R211G, A272P, K277R, G333D, V365I, T377M, A400T, E413D, V435L, R461K, K530R, A554SB
Kinloch (2015)PRRT_125PRRT_125KT167971NoneNone  R72RK, Q85QHLP, D86D*EY, D186DN, R199RK, Q207E, R211K, V245K, I293V, I329V, G333D, G335GC, M357T, K395KRB
Pessoa (2015)10BR_RJ032RJ032KJ849801NoneNone  D123E, I135T, G196E, Q197K, I293V, G333D, Q334H, G359S, K366R, T386I, T403M, V435VA, S468P, H483N, K512RB
Delatorre (2016)13BRRJGN3413BRRJGN34KX357252NoneNone  K20R, A98S, K122E, D123N, I178M, E203D, T240A, V245I, A272P, I293V, G333D, Q334NB
Pessoa (2016)10BR_MG01810BR_MG018KT427683NoneNone M230MLI31IV, K49R, S68G, I135T, G155G*, T165I, E204Q, Q207A, R211K, P243T, V245E, T286A, I293V, E297A, G333D, M357T, S379G, T386I, K390R, A400T, E404D, K431R, E449D, S468P, H483Y, K512R, L517T, S519N, L533M, A554TB
 10BR_PE07410BR_PE074KT427708NoneNone  E6D, V118I, D123E, S162A, D177E, I178V, E204K, Q207E, F214L, V245E, A272P, K277R, K281R, I293V, P294T, E297R, K311R, G333D, T369A, A376S, K390R, A400T, I434L, V435A, S468P, T470K, Q480Y, H483Y, L517IB
 10BR_PE02410BR_PE024KT427735NoneNone V179EV35I, S48T, V60I, T107S, I135V, Q174K, D177E, T200A, I244V, D250E, A272P, A288S, I293V, E297A, G333D, R358K, G359R, K366Q, A376T, T386I, K390R, A400T, T403M, S468P, L469I, H483Y, L491S, Q509T, S519NB
Patiño-Galindo (2017)27060991331016372706099133101637MF404940NoneNone  E169D, Q174K, R211K, A272P, T286A, E297K, G333D, Q334HB
 30058172009492943005817200949294MF404904NoneNone  K49R, R83K, R211K, A272P, K277R, I293V, E297V, D324E, L325I, G333DB
 30871812866327063087181286632706MF404861NoneNone  V60I, S68G, K102Q, K122E, I135T, Q174H, T200TA, R211G, V245E, D250E, I257L, A272P, K277R, I293V, P294S, G333D, Q334HB
 09718332685908270971833268590827MF404648NoneNone  V35T, E36D, V60I, S68G, I135T, I142IT, Q174K, I178L, T200A, Q207K, R211K, A272P, K281R, T286A, A288S, G333D, Q334HB
 52427356410751625242735641075162MF404584NoneNone K103NV35I, V60I, S68G, K122E, I135T, I142T, E169D, Q174K, I178L, T200A, Q207K, R211K, A272P, K277R, A288S, G333DB
 00676282010952380067628201095238MF404409NoneNone  V60I, S68G, K122E, K166R, G196A, T200A, E204Q, R211K, K277R, T286A, G333DB
 18675650298245051867565029824505MF404361NoneNone  K122E, T139Q, I142M, I178M, E204Q, Q207D, R211K, A272P, T286A, E297K, G333DB
 20044676749582662004467674958266MF404088NoneNone  K20R, T39A, R83K, H96HP, K122E, I135T, S162Y, I180IL, G196E, R211K, A272P, I293V, E297K, G333D, G335CB
 32832058340517223283205834051722MF403969NoneNone  V35L, D121H, K122E, I135T, I142X, Q174H, D177E, R211K, A272P, E291D, P294Q, E297X, G333DB
 22214880446646482221488044664648MF403700NoneNone  V35I, V60I, S68G, K122E, I135T, I142T, E169D, Q174K, I178L, T200A, Q207K, R211K, A272P, K277R, K281R, T286A, A288S, G333DB
 60415138043208686041513804320868MF403588NoneNone  V35VI, D123E, I135T, E138A, I142V, S162C, Q174K, R211K, A272P, L283I, I293V, P294S, E297A, K311R, I329L, G333D, Q334HB
 31774222772768883177422277276888MF403448NoneNone  K122P, K173E, Q174R, D177E, I178L, Q207E, R211K, A272P, K277R, E297Q, K311R, S322T, G333D, Q334LB