<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype B
Gene RT
Mutation G333D
Rx RTI-naive
IncludeMixtures No
References 24
Patients 44
Isolates 46
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Coakley (2000)EC36EC36B NoneNone  R211K, V245M, A272P, K277R, I293V, E297K, G333D, R356K, T377A, S468P, H483NB
Carr (2001)ARMS008ARMS008AY037269NoneNone  V21I, Q174H, I178M, Q207E, R211K, V245M, A272P, I293V, I326V, I329V, G333D, Q334N, T386V, T403M, L452I, S468P, T470K, S519NB
Lama (2006)Pt31173117 NoneNone  V35VI, E53D, V60I, R83K, D121Y, K122E, I135T, K173S, Q174K, T200A, R211K, A272P, I293V, P294S, E297K, S322*, G333DB
Margot (2006)72257225BL NoneNone  D123E, K173E, D177E, I178M, T200A, E204K, Q207A, R211K, P243T, E297A, L301M, I326IV, G333D, Q334N, T377L, T386I, K390RB
 76267626BL NoneNone  V35I, K82R, R83K, D123E, I180V, T200A, K281KR, T286A, I293IV, E297K, G333D, K390RB
Pando (2006)04AR15151604AR151516DQ383752NoneNone  D121Y, K122E, I135T, I202V, Q207K, R211K, A272G, T286A, A288S, I293V, E297K, G333D, R356RK, Q373N, S379G, T386I, K390R, E399D, T403M, V435A, K454R, L517I, K530R, A554SB
Brumme (2007)1583PRRT_1583EF368893NoneNone  V35I, S117L, K122Q, K166R, D177E, I178M, G196E, Q207E, V245I, A272P, K277R, I293V, E297A, G333DB
Dilernia (2007)F162F162EF120150NoneNone V179DK20R, K32N, K49R, V60I, K101Q, K122KE, I135K, E169D, D177E, G196E, T200A, V245M, E248X, A272P, K277R, I293V, P294Q, K311R, D324E, I329L, G333D, K366R, A376AS, T386I, K390RB
Holguin (2007)595888595888EF583220NoneNone  R83K, K122E, A158AS, S162C, I178L, Q207K, R211K, A272P, I293V, E297A, K311R, G333DB
 597057597057EF583224NoneNone  K22R, K49R, K122E, I135L, I142T, N175H, V179A, Q197P, R211K, A272P, T286A, T296S, G333D, Q334HB
Sanchez Onoro (2007)595888595888 NoneNone  R83K, K122E, A158AS, S162C, I178L, Q207K, R211K, A272P, I293V, E297A, K311R, G333DB
 597057597057 NoneNone  K22R, K49R, K122E, I135L, I142T, N175H, V179A, Q197P, R211K, A272P, T286A, T296S, G333D, Q334HB
 720501720501 NoneNone  K22R, K49R, K122E, D123DN, I135L, I142T, N175H, V179A, Q197P, R211K, A272P, K277R, T286A, T296S, Y319Y*, G333D, Q334HB
Bang (2008)025BJH_025EF157881NoneNone  V35L, V118I, K122E, I135R, G196E, T200M, E204K, Q207E, F214L, I293V, G333DB
 039BJH_039EF157895NoneNone  E6K, K103KR, V118I, K122E, T139A, G196E, T200K, K201R, Q207DE, F214L, V245K, I270ILRS, K275ILR, I293V, G333D, Q334HB
Holguin (2008)SP58-275600SP58-275600EU255361NoneNone Y181YC, G190SK20R, V35I, V60I, K122KE, E248N, D250E, A272P, A288S, P294T, G333DB
 SP33-302390SP33-302390EU255406NoneNone  V35I, S68G, D123E, I135T, I195L, T200A, R211T, A272P, T286A, A288AT, E297R, K311R, S322T, I329IV, G333D, Q334NB
Miura (2008)BEC51BEC51EU517989NoneNone  R83RK, I135V, I195T, T200TA, V245M, V276I, T286A, I293V, K323R, G333D, A360T, K390R, K431KR, D460N, R461K, L491S, E516VB
Brumme (2009)R0500R0500GQ372121NoneNone  P1PS, K64R, K104R, K122E, D123E, I135V, T139A, K173E, T200A, I202V, E248D, D250N, A272P, I293V, E302EG, G333D, Q334H, M357T, A376S, T377L, K390R, A400I, V435I, A446S, D460N, R461K, S468T, L491S, I506L, S519N, A534SB
 R4543R4543GQ372133NoneNone  V35I, T39S, R83K, V118I, D121H, K122E, K173E, D177E, I178L, R211K, F214L, A272P, K277R, I293V, I329V, G333D, Q334H, M357S, T369A, K390R, A400T, V435I, H483HY, L491LS, A502S, S519N, Q520QK, K527N, A554TB
 R6526R6526GQ372137NoneNone  K11R, D86E, D123E, I135V, S162C, Q174H, R211K, A272P, I293V, E297R, G333D, R356K, T377L, K385R, K390R, A400S, T403M, E404N, V435I, L452S, K454R, R461K, T470A, T472TS, Q524E, V531VAB
 S2513S2513GQ372153NoneNone  V60I, K173T, D177E, R211K, V245M, V254I, A272P, K277R, T286A, I293V, E297K, D324E, G333D, Q334C, R356K, M357V, I375V, K390R, A400T, K431R, V435A, D460S, S468T, T470N, H483N, A554TB
 PRRT_4099PRRT_4099GQ303788NoneNone  V106I, D123DN, I135T, S162C, I178ILM, E204D, R211K, K277R, A288S, I293V, E297A, G333D, A376T, T386I, K390R, E399D, A400T, E432ED, K454R, K558RB
Cuevas (2009)X2629_1X2629_1GU326156NoneNone  K122R, D123E, S162C, R172K, D177E, I178M, I180L, E194K, A272P, K277R, I293V, G333DB
Vercauteren (2009)pt18392261924615GQ399185NoneNone  I135V, S162C, Q174H, R211G, T286A, I293V, V317A, D324DE, I329L, G333DB
 pt11526256491241GQ399872NoneNone  V35I, K49R, R83K, K122PQ, I135T, I142L, E169D, R211K, V245VE, D250DE, A272P, K277R, E291D, K311KR, S322T, D324DE, G333DB
 pt10846700072556GQ399940NoneNone  V21I, D86DE, K102KQ, I135V, S162C, T286A, I293V, E297R, G333DB
 pt8568015329067GQ400168NoneNone  I135T, Q174H, A272P, L283I, P294Q, E297D, G333DB
Bonura (2010)1024_971024_97GU969481NoneNone  E6K, K122E, D123E, I142IV, S162C, G196E, T200A, I202V, L210LS, R211G, A272P, V276T, K277R, L283LI, P294T, E297R, G333DB
Brennan (2010)Pat137ARC-A94JN697242NoneNone  V118I, D123E, A158AS, T165TI, K166R, I178M, Q207E, R211K, F214L, A272P, K277R, I293V, G333D, Q334HB
 Pat062ARC-A176JN697317NoneNone  P4S, R83K, S162A, R211K, V245MT, E248N, D250E, A272P, T286A, I293V, L295F, E297K, G333DB
Descamps (2010)238odyssee238odysseeHQ718071NoneNone  K20R, V60I, V118I, I135R, E169D, Q207E, R211K, F214L, V245Q, A272P, T286A, V317A, I329L, G333DB
Yebra (2010)17381905SP0173819FJ481795NoneNone  V35I, R83K, I178M, T200I, E204T, Q207D, R211K, A272P, T286A, E297Q, S322T, G333D, Q334HB
 24393305SP0243933FJ481801NoneNone  V60I, V90I, K102Q, I135T, E138A, I142V, T165I, I178M, I202V, R211K, F214L, A272P, K277R, P294Q, P313AT, P321PS, D324E, I329L, G333DB
Santos (2011)J350J350_PR_RT_CNJN010733NoneNone  S134C, I135P, D177E, T200A, Q207N, R211K, A272P, A288S, E297K, E300D, G333D, V365I, A376T, T386L, K390R, E399D, L452AB
Avila-Rios (2012)M18CMB9HSUM18CMB9HSUKC169248NoneNone  K103R, D123E, D177E, V179I, R211K, A272P, V276I, T286A, V317A, I329V, G333DB
 D170M85MKED170M85MKEKC168371NoneNone  E204EQ, R211K, F214L, V245T, A272P, P294T, E297D, G333DB
 D270ME0PSED270ME0PSEKC168407NoneNone  V35L, I50V, K122P, I135IV, T139TK, P140T, Q174K, D177E, Q207NS, R211K, K219KT, A272P, K277R, E297K, D324E, G333DB
 D700MB4MTYD700MB4MTYKC168427NoneNone  K20KR, K64R, D121H, K122E, I135T, K173E, Q174H, D177E, I178L, R211K, K238R, A272P, K277KR, G333D, Q334HB
 D800MG1UU5D800MG1UU5KC168434NoneNone  V35M, T39A, R83K, D123E, R211K, A272P, K281KR, T286A, A288G, I293IV, E297K, L310I, S322T, D324DE, I329L, G333D, Q334NB
 B700MD7IS5B700MD7IS5KC168147NoneNone  K20R, K122E, I135V, S162C, T200A, R211K, V245K, T286A, A288S, I293V, E297K, G333DB
 E700M8ADPSE700M8ADPSKC168742NoneNone  V60VI, D123E, I135IR, D177E, I178M, A272P, K275KR, V276VI, K277R, I293V, G333DB
 E8C0MA2LZ9E8C0MA2LZ9KC168759NoneNone  E79D, K102Q, K103R, K122KE, K173R, D177E, T200TA, I202V, R211K, A272APS, T286A, A288S, I293V, E297R, L301I, G333D, Q334HB
Machado (2012)CUPL1087CUPL1087JN000059NoneNone  A98S, K122E, I135M, S162C, D177E, I178M, R211K, F214L, K220Y, K223I, L228H, V245E, D250E, A272P, K277R, T286A, E297T, I329V, G333D, K350R, R358K, G359N, A376S, V381I, K390RB
Lunar (2013)pt14504558440144GQ399574NoneNone V179DK20R, T200I, V245E, K277R, A288S, V292I, I293V, P294T, I326V, G333DB
Tramuto (2013)CV1320_102CV1320_102HQ667697NoneNone  V35I, V106I, K122E, I142IM, S162ST, K166KR, I178M, Q197P, A272P, E297A, S322T, I329V, G333DB