Reverse Transcriptase Inhibitors

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Reverse Transcriptase Inhibitors

Subtype	B
Gene	RT
Mutation	K219R
Rx	>= 1 NRTI (but no NNRTI)
IncludeMixtures	No

References	25
Patients	38
Isolates	45

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	NRTIs	NNRTIs	NRTIDRMs	NNRTIDRMs	OtherMut	Subtype
Ruiz (1996)	JCS-C3	C3W24	Z99301	DDC, AZT, 3TC	None	M41L, L210W, T215Y, K219R		E44D, V118I, K122E, T200A, E203K, H208Y, R211K, K223E, L228R	B
Lawrence (1999)	CA1165	CA10423	AY802598	AZT, DDC, D4T, 3TC	None	M41L, D67DN, T69D, M184V, T215Y, K219R		K20R, V60I, V118I, K122E, I135M, G196E, F214FL, L228H	B
Pellegrin (1999)	IP-6	IP6-M12		D4T, DDI	None	K219R		Q23QK, I135T, K173KR, R211K	B
Albrecht (2000)	ACTG303_2977	2977RT_bl		AZT, DDI	None	M41L, T69D, L210W, T215Y, K219R		K20R, V35I, K43E, E44A, A98S, V118I, E204K, R211D, L228H, A272P, T286A	B
		2977RT_f1		AZT, DDI, 3TC	None	M41L, T69D, L210W, T215Y, K219R		K20R, V35M, K43E, E44A, A98S, T107TP, V118I, E204K, R211D, L228H, A272P, T286A	B
Balotta (2000)	CB-129	CB-129	AF252000	D4T, 3TC, DDC, AZT, DDI	None	M41L, D67N, L74I, L210W, T215Y, K219R		V35L, T39K, K43E, E44D, T69TI, L80LF, T107TP, V111I, V118I, K122E, S134SR, I135T, I142V, I178L, G196E, E203D, H208Y, R211K, K223Q	B
	CB-160	CB-160	AF251977	D4T, 3TC, DDC, AZT, DDI	None	M41L, D67N, T69D, V75T, F77FL, L210W, T215Y, K219R		K20R, I31IL, V35I, R83K, Q91QK, A114AE, S117S*PQ, V148G, K166R, Q207QE, H208Y, R211K, K223Q	B
	CB-206	CB-206	AF252043	DDC, AZT, D4T, 3TC, DDI	None	M41L, D67N, M184MI, L210W, T215Y, K219R		K20R, V35M, K43Q, E44D, V60I, T69TI, L80LF, V118I, K122P, K166R, Q174E, D177E, I178L, E203K, R211K, K223Q	B
Baxter (2000)	GART-NG84	GART-84		NRTI, AZT, 3TC	None	M41L, T69D, V75M, M184V, L210W, T215Y, K219R		K43Q, E44D, A98S, V118I, K122E, I135L, G196E, E203EK, R211K, L228H, V245M	B
Falloon (2000)	JF10	JF10-(-)1w	AF227723	AZT, DDI, DDC, D4T, 3TC, PFA	None	M41L, D67N, T69D, L74LI, V75T, M184I, L210W, T215C, K219R	V108I	V118I, K122E, I178M, G196E, E203K, R211E, F214X	B
		JF10-12w	AF227724	AZT, DDI, DDC, D4T, 3TC, PFA, ABC	None	M41L, D67N, T69D, L74LI, V75T, M184I, L210W, T215C, K219R	V108I	V118I, K122E, I178M, G196E, E203K, R211E	B
Rousseau (2000)	MNR1	MNR1	AJ405947	AZT, DDI, D4T, 3TC	None	M41L, D67N, M184V, L210W, T215Y, K219R		K32N, V35I, E44D, V106I, V118I, K122P, I135K, H208Y, R211K, K277R, T286A, I293V, E297K, Q334E, M357T, T369V, A371V, I375V, A376T, K390R, A400T, Y405H, V435I, A445Q, A446L, N447T, K454R	B
Albrecht (2001)	ACTG364_2263	2263		AZT, DDC	None	M41L, T69D, L210W, T215Y, K219R		K43E, E44A, A98S, V118I, Q207D, R211K, L228R, V245E, I293V	B
Eshleman (2001)	A026	AF357629	AF357629	AZT, DDI	None	M41L, T69D, L210W, T215Y, K219R		A98S, V118I, G196GE, T200I, E203EK, Q207QE, H208HY, R211K, V245K, D250E	B
Gonzales (2001)	CA1484	CA4250	AY030610	DDI, DDC, AZT, D4T, 3TC	None	M41ML, D67N, M184V, L210W, T215Y, K219R		E28K, K32E, E44ED, V60VI, R83K, K122E, S162Y, E169D, D177E, I178L, E204ED, R211K, A272P	B
	CA1826	CA4913	AY030739	DDC, D4T, 3TC	None	M41L, M184V, L210W, T215Y, K219R		K43Q, V60I, V118I, E203K, Q207E, R211K, E224ED, L228H, A272P, K287KT, I293V	B
	CA4566	CA11192	AY031363	AZT, D4T, 3TC	None	M184V, K219R		D123E, D177E, I178V, V179I, R211X, F214L, L228H, A272S, T286A, I293V	B
	CA4578	CA11204	AY031375	AZT, DDC, D4T, 3TC	None	M41L, D67DN, T69D, M184V, L210W, T215Y, K219R		V21I, V35I, E44D, R83K, K122E, T200A, E203K, H208Y, R211K, K223E, L228H, A272P, K281R, I293V, E297Q	B
	CA5147	CA12440	AY031713	AZT, DDC, 3TC	None	M41L, M184V, L210W, T215Y, K219R		K43S, E44D, E53D, V118I, K122E, S162Y, Q174E, Q197L, E203K, R211K, K223Q, L228R, A272P, T286A	B
Papa (2002)	AP_GR49	AP_GR49	AY046881	D4T, DDI, AZT, 3TC	None	M41L, D67N, L74LV, L210W, T215Y, K219R	V108I	K43E, E44D, L109I, V118VI, K122Q, D123DE, I178L, V189I, G196E, I202T, H208HY, R211K, E224D	B
Tural (2002)	880416	880416		DDC, AZT, 3TC, D4T	None	M41L, D67N, M184V, L210W, T215Y, K219R		E44D, V118I, K122E, I135T, T200I, E203D, H208Y, R211K, D218E	B
	880723	880723		AZT, 3TC	None	K219R		V35I, I50V, R83K, I135T, K166R, D177E, Q207A	B
Gonzales (2003)	CA1484	CA14514	AF514081	DDI, DDC, AZT, D4T, 3TC	None	M41ML, D67N, L210W, T215Y, K219R		V21I, E28K, K32E, V60I, R83K, K122E, S162Y, E169D, D177E, I178L, R211K, Q258QHY, K259K, A272P	B
Gonzales (2003)	CA1848	4675-1	AY351773	3TC, D4T	None	D67N, M184V, L210W, T215Y, K219R		E28K, K32E, R83K, K122E, S162Y, E169D, D177E, I178L, R211K, A272P, R284RS	B
Gonzales (2003)	CA3871	CA10950	AF514155	DDI, DDC, AZT, 3TC, D4T	None	M41L, D67N, T69D, M184V, L210W, T215Y, K219R	V108I	V35I, K43Q, E44D, V60I, V118I, K122E, D123N, I135M, G196E, H208Y, R211K, H221Y, A272P, I293IL, G335S, M357MT, E370EK, A371V, I375V, A400T, E404D, V435E, K451R, D460N, S468P, H483HY, L491LQ, S519N, K530KR	B
Roge (2003)	ea1	ea1-F	AY222051	ABC, D4T, DDI	None	K65R, K219R	V179D	S68SG, T107TA, D123E, I135T, A158S, E169D, T200A, R211RK, F214L	B
	so7	so7-F1	AY222065	ABC, D4T, DDI	None	M41L, D67N, L74V, L210W, T215Y, K219R		V60I, L120I, E204Q, R211K, D218E	B
		so7-F2	AY222066	ABC, D4T, DDI	None	M41L, D67N, L74V, L210W, T215Y, K219R		V60I, K64N, R72RK, E204Q, R211K, D218E	B
Dumans (2004)	170	170	AY390132	AZT, DDI	None	L210W, T215Y, K219R		G196E, K220E	B
Machado (2004)	con29	con29	AY313407	AZT, DDI, 3TC, D4T	None	M41L, T69D, L210W, T215Y, K219R		K122E, I135T, D177E, G196E, T200A	B
	cs137	cs137	AY313416	DDI, AZT	None	M41L, T69D, L210W, T215Y, K219R		K49R, V60I, K122E, I135T, I142V, Q207E, K223Q	B
Gallant (2005)	JEG30	JEG30_w12	DQ199603	ABC, TDF, 3TC	None	K65KR, M184MIV, K219R		V35L, S48T, K102Q, K104R, K122E, D123N, S162Y, E169D, K173KR, D177E, V179I, A272PS	B
Mo (2005)	9182	9182_d1		NRTI	None	M41L, T69D, M184V, L210W, T215Y, K219R	K103KN, V106VA, Y181YC	T39A, E44D, V118I, K122E, I142V, S162FY, E203K, Q207E, H208HY, R211K, K223E, E224K, L228LH, Q242K, A288AS, E297K	B
Non-B Workgroup (2005)	BR8	BR8		AZT, DDI, 3TC, D4T	None	M41L, D67N, L74V, L210W, T215Y, K219R		K20R, K32R, T39S, V60I, V90I, V118I, I142V, E169D, H208Y, R211K, K223Q	B
Rhee (2005)	SWC-3926	P3926-148		DDC, AZT, 3TC, D4T	None	M41L, T69D, M184V, L210W, T215Y, K219R		E44D, V118I, S162C, R211K, L228R	B
	CA5147	CA15810	AY801493	AZT, DDC, 3TC, D4T, DDI	None	M41L, M184MV, L210W, T215Y, K219R		K43S, E44D, E53D, V118I, K122E, S162Y, Q174E, Q197L, E203EK, R211K, K223Q, L228R, A272P, T286A	B
	CA7848	CA19878	AY801794	AZT, DDI, D4T, 3TC, ABC	None	M41L, D67G, T69D, V75VL, M184I, L210W, T215Y, K219R		K43KN, E44D, V60I, V118I, K122E, D123E, I135T, I142V, G196E, I202X, E203EK, Q207E, H208Y, R211K, H221HY, K223KE, V245K, A272P	B
		CA23659	AY801795	AZT, DDI, D4T, 3TC, ABC	None	M41L, D67G, T69D, M184I, L210W, T215Y, K219R	F227FL	T39TP, K43KN, E44D, S48SP, V60I, V118I, K122E, D123E, I135T, I142V, G196E, E203K, Q207E, H208Y, R211K, K223E, V245K, A272P, M357T, I375V, K390R, A400T, V435I, V458I, L469I, S519N, K527Q, A554S, K558R	B
	CA9700	CA37961	AY802073	D4T, 3TC	None	M41L, D67N, M184I, L210W, T215Y, K219R		E6ED, K43Q, E44D, V90I, K104R, V118I, G196E, E203K, Q207E, H208Y, R211K, K223E, V292I, I293V	B
	CA17694	CA41631	AY802545	D4T, 3TC	None	M41L, A62V, D67G, M184V, L210W, T215Y, K219R	V108I	K20R, K43Q, E44D, K102S, V106I, T107A, V118I, K122E, Q174E, G196E, H208Y, R211K, K223Q, L228H, E297K, K350E	B
Rhee (2006)	CA6361	CA59609		AZT, DDI, 3TC, ABC, D4T	None	M41L, D67N, L210W, T215Y, K219R		E6DN, K20R, T39E, E44D, V60I, V118VI, K122E, T131TI, Q207E, D218E, E248D, A272AP, T286A, E297K, I326V	B
Rhee (2009)	CA14225	CA34363	FJ983352	AZT, DDC, 3TC, D4T	None	M41L, D67G, T69D, L210W, T215Y, K219R		E6D, V60VI, V118I, K122E, D123E, I135V, I142V, S162C, R211K, V245K, I293V	B
	CA30205	CA69087	FJ983557	ABC, AZT	None	M41L, D67N, T215Y, K219R		V60VI, K122E, I135T, G196E, T200A, H208HY, D218E, V245L, E248D, Q278E	B
		CA84348	FJ983559	ABC, AZT, TDF, FTC	None	M41L, D67N, M184V, T215Y, K219R		E44ED, V60I, K122E, I135T, G196E, T200A, H208Y, D218E, L228H, V245L, E248D, K275KR, Q278E, V292I, I293V, E297K	B
von Wyl (2010)	4795747	4795747	GQ848121	AZT, DDI, DDC, D4T, 3TC	None	M41L, D67DN, L74I, M184MI, T215Y, K219R		V35VI, K43Q, E44D, V118I, K122E, D123N, I135T, S162C, Q207E, L210LS, R211K, D218E, V245K, K277R, T286TA, I293V, E297Q, I329V, A360AT, K390R	B

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