<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype B
Gene RT
Mutation K219R
Rx >= 1 NRTI
(but no NNRTI)
IncludeMixtures No
References 26
Patients 39
Isolates 49
 
Show mutation frequency as:
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Ruiz (1996)JCS-C3C3W24Z99301DDC, AZT, 3TCNoneM41L, L210W, T215Y, K219R E44D, V118I, K122E, T200A, E203K, H208Y, R211K, K223E, L228RB
Lawrence (1999)CA1165CA10423AY802598AZT, DDC, D4T, 3TCNoneM41L, D67DN, T69D, M184V, T215Y, K219R K20R, V60I, V118I, K122E, I135M, G196E, F214FL, L228HB
Pellegrin (1999)IP-6IP6-M12 D4T, DDINoneK219R Q23QK, I135T, K173KR, R211KB
Albrecht (2000)ACTG303_29772977RT_bl AZT, DDINoneM41L, T69D, L210W, T215Y, K219R K20R, V35I, K43E, E44A, A98S, V118I, E204K, R211D, L228H, A272P, T286AB
  2977RT_f1 AZT, DDI, 3TCNoneM41L, T69D, L210W, T215Y, K219R K20R, V35M, K43E, E44A, A98S, T107TP, V118I, E204K, R211D, L228H, A272P, T286AB
Balotta (2000)CB-129CB-129AF252000D4T, 3TC, DDC, AZT, DDINoneM41L, D67N, L74I, L210W, T215Y, K219R V35L, T39K, K43E, E44D, T69TI, L80LF, T107TP, V111I, V118I, K122E, S134SR, I135T, I142V, I178L, G196E, E203D, H208Y, R211K, K223QB
 CB-160CB-160AF251977D4T, 3TC, DDC, AZT, DDINoneM41L, D67N, T69D, V75T, F77FL, L210W, T215Y, K219R K20R, I31IL, V35I, R83K, Q91QK, A114AE, S117S*PQ, V148G, K166R, Q207QE, H208Y, R211K, K223QB
 CB-206CB-206AF252043DDC, AZT, D4T, 3TC, DDINoneM41L, D67N, M184MI, L210W, T215Y, K219R K20R, V35M, K43Q, E44D, V60I, T69TI, L80LF, V118I, K122P, K166R, Q174E, D177E, I178L, E203K, R211K, K223QB
Baxter (2000)GART-NG84GART-84 NRTI, AZT, 3TCNoneM41L, T69D, V75M, M184V, L210W, T215Y, K219R K43Q, E44D, A98S, V118I, K122E, I135L, G196E, E203EK, R211K, L228H, V245MB
Falloon (2000)JF10JF10-(-)1wAF227723AZT, DDI, DDC, D4T, 3TC, PFANoneM41L, D67N, T69D, L74LI, V75T, M184I, L210W, T215C, K219RV108IV118I, K122E, I178M, G196E, E203K, R211E, F214XB
  JF10-12wAF227724AZT, DDI, DDC, D4T, 3TC, PFA, ABCNoneM41L, D67N, T69D, L74LI, V75T, M184I, L210W, T215C, K219RV108IV118I, K122E, I178M, G196E, E203K, R211EB
Rousseau (2000)MNR1MNR1AJ405947AZT, DDI, D4T, 3TCNoneM41L, D67N, M184V, L210W, T215Y, K219R K32N, V35I, E44D, V106I, V118I, K122P, I135K, H208Y, R211K, K277R, T286A, I293V, E297K, Q334E, M357T, T369V, A371V, I375V, A376T, K390R, A400T, Y405H, V435I, A445Q, A446L, N447T, K454RB
Albrecht (2001)ACTG364_22632263 AZT, DDCNoneM41L, T69D, L210W, T215Y, K219R K43E, E44A, A98S, V118I, Q207D, R211K, L228R, V245E, I293VB
Eshleman (2001)A026AF357629AF357629AZT, DDINoneM41L, T69D, L210W, T215Y, K219R A98S, V118I, G196GE, T200I, E203EK, Q207QE, H208HY, R211K, V245K, D250EB
Gonzales (2001)CA1484CA4250AY030610DDI, DDC, AZT, D4T, 3TCNoneM41ML, D67N, M184V, L210W, T215Y, K219R E28K, K32E, E44ED, V60VI, R83K, K122E, S162Y, E169D, D177E, I178L, E204ED, R211K, A272PB
 CA1826CA4913AY030739DDC, D4T, 3TCNoneM41L, M184V, L210W, T215Y, K219R K43Q, V60I, V118I, E203K, Q207E, R211K, E224ED, L228H, A272P, K287KT, I293VB
 CA4566CA11192AY031363AZT, D4T, 3TCNoneM184V, K219R D123E, D177E, I178V, V179I, R211X, F214L, L228H, A272S, T286A, I293VB
 CA4578CA11204AY031375AZT, DDC, D4T, 3TCNoneM41L, D67DN, T69D, M184V, L210W, T215Y, K219R V21I, V35I, E44D, R83K, K122E, T200A, E203K, H208Y, R211K, K223E, L228H, A272P, K281R, I293V, E297QB
 CA5147CA12440AY031713AZT, DDC, 3TCNoneM41L, M184V, L210W, T215Y, K219R K43S, E44D, E53D, V118I, K122E, S162Y, Q174E, Q197L, E203K, R211K, K223Q, L228R, A272P, T286AB
Papa (2002)AP_GR49AP_GR49AY046881D4T, DDI, AZT, 3TCNoneM41L, D67N, L74LV, L210W, T215Y, K219RV108IK43E, E44D, L109I, V118VI, K122Q, D123DE, I178L, V189I, G196E, I202T, H208HY, R211K, E224DB
Tural (2002)880416880416 DDC, AZT, 3TC, D4TNoneM41L, D67N, M184V, L210W, T215Y, K219R E44D, V118I, K122E, I135T, T200I, E203D, H208Y, R211K, D218EB
 880723880723 AZT, 3TCNoneK219R V35I, I50V, R83K, I135T, K166R, D177E, Q207AB
Gonzales (2003)CA1484CA14514AF514081DDI, DDC, AZT, D4T, 3TCNoneM41ML, D67N, L210W, T215Y, K219R V21I, E28K, K32E, V60I, R83K, K122E, S162Y, E169D, D177E, I178L, R211K, Q258Q*HY, K259K*, A272PB
Gonzales (2003)CA18484675-1AY3517733TC, D4TNoneD67N, M184V, L210W, T215Y, K219R E28K, K32E, R83K, K122E, S162Y, E169D, D177E, I178L, R211K, A272P, R284RSB
Gonzales (2003)CA3871CA10950AF514155DDI, DDC, AZT, 3TC, D4TNoneM41L, D67N, T69D, M184V, L210W, T215Y, K219RV108IV35I, K43Q, E44D, V60I, V118I, K122E, D123N, I135M, G196E, H208Y, R211K, H221Y, A272P, I293IL, G335S, M357MT, E370EK, A371V, I375V, A400T, E404D, V435E, K451R, D460N, S468P, H483HY, L491LQ, S519N, K530KRB
Roge (2003)ea1ea1-FAY222051ABC, D4T, DDINoneK65R, K219RV179DS68SG, T107TA, D123E, I135T, A158S, E169D, T200A, R211RK, F214LB
 so7so7-F1AY222065ABC, D4T, DDINoneM41L, D67N, L74V, L210W, T215Y, K219R V60I, L120I, E204Q, R211K, D218EB
  so7-F2AY222066ABC, D4T, DDINoneM41L, D67N, L74V, L210W, T215Y, K219R V60I, K64N, R72RK, E204Q, R211K, D218EB
Dumans (2004)170170AY390132AZT, DDINoneL210W, T215Y, K219R G196E, K220EB
Machado (2004)con29con29AY313407AZT, DDI, 3TC, D4TNoneM41L, T69D, L210W, T215Y, K219R K122E, I135T, D177E, G196E, T200AB
 cs137cs137AY313416DDI, AZTNoneM41L, T69D, L210W, T215Y, K219R K49R, V60I, K122E, I135T, I142V, Q207E, K223QB
Gallant (2005)JEG30JEG30_w12DQ199603ABC, TDF, 3TCNoneK65KR, M184MIV, K219R V35L, S48T, K102Q, K104R, K122E, D123N, S162Y, E169D, K173KR, D177E, V179I, A272PSB
Mo (2005)91829182_d1 NRTINoneM41L, T69D, M184V, L210W, T215Y, K219RK103KN, V106VA, Y181YCT39A, E44D, V118I, K122E, I142V, S162FY, E203K, Q207E, H208HY, R211K, K223E, E224K, L228LH, Q242K, A288AS, E297KB
Non-B Workgroup (2005)BR8BR8 AZT, DDI, 3TC, D4TNoneM41L, D67N, L74V, L210W, T215Y, K219R K20R, K32R, T39S, V60I, V90I, V118I, I142V, E169D, H208Y, R211K, K223QB
Rhee (2005)SWC-3926P3926-148 DDC, AZT, 3TC, D4TNoneM41L, T69D, M184V, L210W, T215Y, K219R E44D, V118I, S162C, R211K, L228RB
 CA5147CA15810AY801493AZT, DDC, 3TC, D4T, DDINoneM41L, M184MV, L210W, T215Y, K219R K43S, E44D, E53D, V118I, K122E, S162Y, Q174E, Q197L, E203EK, R211K, K223Q, L228R, A272P, T286AB
 CA7848CA19878AY801794AZT, DDI, D4T, 3TC, ABCNoneM41L, D67G, T69D, V75VL, M184I, L210W, T215Y, K219R K43KN, E44D, V60I, V118I, K122E, D123E, I135T, I142V, G196E, I202X, E203EK, Q207E, H208Y, R211K, H221HY, K223KE, V245K, A272PB
  CA23659AY801795AZT, DDI, D4T, 3TC, ABCNoneM41L, D67G, T69D, M184I, L210W, T215Y, K219RF227FLT39TP, K43KN, E44D, S48SP, V60I, V118I, K122E, D123E, I135T, I142V, G196E, E203K, Q207E, H208Y, R211K, K223E, V245K, A272P, M357T, I375V, K390R, A400T, V435I, V458I, L469I, S519N, K527Q, A554S, K558RB
 CA9700CA37961AY802073D4T, 3TCNoneM41L, D67N, M184I, L210W, T215Y, K219R E6ED, K43Q, E44D, V90I, K104R, V118I, G196E, E203K, Q207E, H208Y, R211K, K223E, V292I, I293VB
 CA17694CA41631AY802545D4T, 3TCNoneM41L, A62V, D67G, M184V, L210W, T215Y, K219RV108IK20R, K43Q, E44D, K102S, V106I, T107A, V118I, K122E, Q174E, G196E, H208Y, R211K, K223Q, L228H, E297K, K350EB
Rhee (2006)CA6361CA59609 AZT, DDI, 3TC, ABC, D4TNoneM41L, D67N, L210W, T215Y, K219R E6DN, K20R, T39E, E44D, V60I, V118VI, K122E, T131TI, Q207E, D218E, E248D, A272AP, T286A, E297K, I326VB
Rhee (2009)CA14225CA34363FJ983352AZT, DDC, 3TC, D4TNoneM41L, D67G, T69D, L210W, T215Y, K219R, N348I E6D, V60VI, V118I, K122E, D123E, I135V, I142V, S162C, R211K, V245K, I293V, M357T, T369A, A400I, K451R, S468P, L469I, T470EKB
 CA30205CA69087FJ983557ABC, AZTNoneM41L, D67N, T215Y, K219R V60VI, K122E, I135T, G196E, T200A, H208HY, D218E, V245L, E248D, Q278EB
  CA84348FJ983559ABC, AZT, TDF, FTCNoneM41L, D67N, M184V, T215Y, K219R E44ED, V60I, K122E, I135T, G196E, T200A, H208Y, D218E, L228H, V245L, E248D, K275KR, Q278E, V292I, I293V, E297KB
von Wyl (2010)47957474795747GQ848121AZT, DDI, DDC, D4T, 3TCNoneM41L, D67DN, L74I, M184MI, T215Y, K219R V35VI, K43Q, E44D, V118I, K122E, D123N, I135T, S162C, Q207E, L210LS, R211K, D218E, V245K, K277R, T286TA, I293V, E297Q, I329V, A360AT, K390RB
Grossman (2014)3333KF1350563TC, DDINoneM41L, D67N, T69D, V75M, M184V, L210W, T215Y, K219R E44D, V60I, V118I, K122E, S134SG, Q174K, N175Y, G196E, T200R, Q207E, R211A, D218EB
  33KF1350573TC, DDINoneM41L, D67N, T69D, K70KR, V75M, F77L, M184I, L210W, T215Y, K219R I37L, E44D, N57D, T58N, V60I, K65KE, K82KR, T84TA, D110DG, V118I, K122E, K126E, Q174K, N175Y, G196E, T200R, E203V, Q207E, R211A, D218E, Q242QLB
  33KF1350583TC, DDI, D4TNoneM41L, D67N, T69D, V75M, M184I, L210W, T215Y, K219RK101KE, V108VI, Y181YC, G190GAI37L, E44D, V60I, V118I, K122E, K126KE, Q174K, N175Y, E194ED, G196E, T200R, E203V, Q207E, R211A, D218E, Q242LB
  33 3TC, DDI, D4TNoneM41L, D67N, T69D, V75M, M184I, L210W, T215Y, K219RV108II37L, E44D, V60I, V118I, K122E, Q174K, N175Y, V179VI, G196E, T200R, E203V, Q207E, R211A, D218E, L228V, Q242LB