<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype B
Gene RT
Mutation K219N
Rx >= 1 NRTI
(but no NNRTI)
IncludeMixtures No
References 13
Patients 32
Isolates 37
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Ruiz (1996)JCS-C45C45W24Z99335AZT, DDI, 3TCNoneM41L, D67N, M184V, L210W, T215Y, K219N K20R, E44D, V118I, K122E, G196E, Q197T, E203K, Q207K, H208Y, R211A, V245MB
Hammer (1997)ACTG320_12791279 AZT, DDCNoneM41L, D67N, K70R, L210W, T215Y, K219N E44D, V60I, V118I, K122E, I135T, G196E, H208Y, R211K, A272P, I293IV, I329V, G359S, A371V, A376T, T377Q, K451R, D460N, R461RK, L469I, H483YB
 ACTG320_23372337 AZT, DDINoneM41L, D67N, T69D, L210W, T215Y, K219N K20R, V35E, T39A, E40F, K43E, V118I, K122KE, E138G, I142T, S162C, G196E, Q207E, R211K, V245VE, A272P, K277R, I293V, E297A, G333EB
 ACTG320_453453 AZT, DDI, D4T, 3TCNoneM41L, D67N, L210W, T215Y, K219NV179E, Y181CK32DE, V35VL, T39A, E44D, D123E, I135K, S163SC, I167IV, E169ED, K173E, I178L, G196E, T200A, R211K, L228H, A272P, K277R, E297A, V317A, Y342F, R358RK, T377M, K390R, A400T, K431T, V435I, L469I, T470TN, D488XB
Shafer (1998)HMDR-33-197CAF047294AZT, DDI, 3TC, D4TNoneM41L, D67N, M184V, L210W, T215Y, K219N V35I, E40E*DY, K43N, V60I, A98S, V118I, K122E, I135V, G196GE, Q207E, R211KB
 HMDR-44AF047299AZT, DDC, DDI, D4T, 3TCNoneM41L, D67N, L74I, M184V, L210W, T215Y, K219NA98GK43E, E44A, K64R, R83K, V118I, Q161P, S163C, G196E, H208Y, R211K, D218EB
Balotta (2000)CB-253CB-253AF252056AZT, 3TC, DDINoneM41L, A62AV, D67N, M184V, L210W, T215Y, K219N E44D, A114AE, D123E, I135T, I142V, S162A, D177E, T200A, I202V, H208Y, R211KB
 CB-304CB-304AF251981DDC, AZT, D4T, 3TCNoneM41L, D67N, M184MV, L210W, T215Y, K219N K20R, V35I, T39A, K43KE, K49R, V118I, A158S, E169D, G196GE, E203K, H208HY, R211K, L282LF, E297R, V317AB
Falloon (2000)JF03JF03-8wAF227712AZT, DDI, DDC, D4T, 3TC, ABCNoneM41L, D67N, T69D, M184V, L210W, T215Y, K219N E44D, A98S, K122E, D123E, D177E, R211KB
Albrecht (2001)ACTG364_12041204 AZT, DDI, 3TCNoneM41L, D67N, M184L, L210W, T215Y, K219N I31IL, R83RK, V90I, V118I, K122P, I135IV, S162CY, I178M, G196E, E203V, A272P, K277RB
 ACTG364_34693469 AZT, DDI, 3TCNoneM41L, D67N, M184V, L210W, T215Y, K219N K43Q, E44A, V118I, A158S, E169ED, G196GE, Q207E, R211K, V245TB
 ACTG364_61516151 DDC, AZT, 3TCNoneM41L, D67N, M184V, L210W, T215Y, K219N V35I, T39TA, K43E, E44EA, D121Y, K122E, I135T, S162C, K166KQ, D177E, G196E, R211K, A272P, R284RKB
Gonzales (2001)CA620CA1181AY030417AZT, DDC, DDI, 3TCNoneM41L, D67N, M184V, L210W, T215Y, K219N E44D, V60I, V118I, K122E, I135V, G196E, E203K, Q207E, R211KB
 CA631CA1203AY030419AZT, DDC, D4T, DDI, 3TCNoneM41L, D67N, V75M, M184V, L210W, T215Y, K219N E6D, V35X, T39A, E44D, V118I, K173T, E203K, Q207D, H208Y, R211KB
 CA1148CA2609AY030459AZT, DDI, 3TC, D4TNoneM41L, D67N, K70KR, V75M, M184MV, L210W, T215Y, K219N K20R, E44D, V60I, D123E, I142V, S162Y, G196E, Q197K, H208F, R211KB
 CA1155CA2627AY030464NRTINoneM41L, D67N, L210W, T215Y, K219N V35I, K43Q, E44D, V118I, D121H, K122E, I135T, D177E, G196E, H208Y, R211K, V245KB
 CA1259CA3026AY030488AZT, DDC, D4T, 3TCNoneM41L, D67N, M184V, L210W, T215Y, K219N E44D, V118I, K122E, D123E, D177E, I178M, H208Y, R211K, E248D, A272P, K277X, T286A, E297K, A299XB
 CA1555CA4444AY030672AZT, DDI, NRTI, 3TC, D4TNoneM41L, D67N, K70KR, M184V, T215Y, K219N K20R, V60I, A98S, I135T, K166R, E169D, G196E, T200A, R211RS, V245MB
 CA1624CA4604AY030712DDC, AZT, 3TC, D4T, DDINoneM41L, D67N, L210W, T215Y, K219N T39A, E44D, H208Y, R211K, V245T, N265NT, K277R, C280CR, R284K, T286A, V292I, E297KB
 CA2073CA7679AY030783DDC, AZT, DDI, D4T, 3TCNoneM41L, D67N, M184V, L210W, T215Y, K219N T27S, K43E, E44A, V118I, K122E, I142IV, A158S, I202V, R211K, N265NT, A272P, C280CRB
 CA3972CA9217AY030970AZT, 3TC, D4TNoneM41L, D67N, M184V, L210W, T215Y, K219NK101HK43E, E44A, K122E, I142V, S162C, E169D, H208Y, R211K, V245MB
 CA5102CA12385AY031670AZT, DDC, 3TC, D4TNoneM41L, D67N, M184V, L210W, T215Y, K219N K20R, V35X, K43E, E44A, A98S, V118I, K122KE, G196GE, H208Y, R211K, V245K, D250E, S251SCB
Katzenstein (2001)ACTG302_20982098RT_f1 AZT, DDI, 3TCNoneM41L, D67N, M184V, L210W, T215Y, K219N R83K, V90I, V118I, K122P, I135V, T139HN, S162C, I178M, G196E, E203V, A272P, K277R, I293V, P294T, E300E*B
 ACTG302_36233623RT_f1 AZT, DDI, 3TCNoneM41L, D67N, M184V, L210W, T215Y, K219N K11R, Q23QH, K43Q, E44D, V60I, L100LF, V118I, D123E, I135L, S162Y, Q207E, R211KB
Servais (2001)JS6JS98371AJ401823AZT, DDI, DDC, D4T, 3TCNoneM41L, D67N, K70R, M184V, L210W, T215Y, K219N V111I, I135T, S163C, D177E, I178M, E194G, G196E, T200I, H208Y, R211K, V245TB
Papa (2002)AP-13AP-13AF315756AZT, 3TC, D4T, DDINoneM41L, D67N, M184V, L210W, T215Y, K219N K43KQ, E44D, V118I, K122E, I135T, D177E, V179I, G196E, T200A, E203D, H208Y, R211KB
Gonzales (2003)CA1148CA10560AF514021AZT, DDI, 3TC, D4TNoneM41L, D67N, V75M, M184V, L210W, T215Y, K219N K20R, E44D, V60I, K122KE, D123E, I142V, S162Y, G196E, Q197K, E203D, H208F, R211K, S251I, A272P, I293VB
  CA35549AY802725AZT, DDI, 3TC, D4TNoneM41L, D67N, V75M, M184V, L210W, T215Y, K219N T7TP, K20R, E44D, V60I, D123E, I142V, S162Y, G196E, Q197K, E203D, H208F, R211K, S251I, A272P, I293VB
 CA3972CA17451AF514168AZT, 3TC, D4T, ABCNoneM41L, D67N, L74I, L210W, T215Y, K219NK101HE40F, K43E, V118I, K122E, S162C, E169D, H208Y, R211K, V245M, Q278QH, I293VB
Rhee (2005)CA1148CA17417AY800771AZT, DDI, 3TC, D4T, ABC, NRTINoneM41L, D67N, K70KR, V75M, M184V, L210W, T215Y, K219N K20R, K43Q, E44D, V60I, K122E, D123X, I142V, S162Y, G196E, Q197K, E203D, H208F, R211K, S251I, A272P, K281KE, I293V, A299AGB
 CA1590CA9315AY801052DDC, AZT, D4T, 3TC, DDINoneM41L, D67N, T69D, M184V, L210W, T215Y, K219N E44D, V60I, V118I, K122E, I135T, G196E, T200I, E203K, Q207E, H208Y, R211K, K223EB
 SWC-2224P2224-464 AZT, DDC, D4T, 3TCNoneM41L, M184V, L210W, T215Y, K219N E42X, E44X, S68G, R83S, I135T, I178M, R211QB
  P2224-773 AZT, DDC, D4T, 3TCNoneM41L, M184V, L210W, T215Y, K219N S68G, I135T, I178M, R211QB
 SWC-4651P4651-319 DDC, AZT, 3TC, D4T, DDINoneM41L, M184V, L210W, T215Y, K219N V35M, T39A, K43E, E44D, D123E, K166R, D177E, I202V, E203D, H208Y, R211KB
 CA7119CA17469AY801790AZT, DDC, 3TCNoneM41L, D67N, M184V, L210W, T215Y, K219N K43E, E44A, V60I, V118I, D121Y, K122E, I135T, D177E, I178M, H208Y, R211K, K281KE, V292I, I293V, A299AGB
 CA14611CA35024AY802389AZT, 3TCNoneM41L, L74I, M184V, L210W, T215Y, K219N V35VE, T39A, E40F, K43E, V60I, S68G, V118I, K122E, K166R, G196E, T200I, R211K, A272P, I293V, E302DB
Rodrigues (2005)BR04511800AY441879D4T, DDI, ABC, AZT, 3TCNoneM41L, D67N, T69D, M184V, L210*W, T215Y, K219N E6D, T39N, K43E, E44A, A98AP, D110DN, V118I, K122E, I135T, V179I, T200TA, H208Y, R211K, K223Q, V245TB