Reverse Transcriptase Inhibitors

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Reverse Transcriptase Inhibitors

Subtype	B
Gene	RT
Mutation	K219N
Rx	>= 1 NRTI (but no NNRTI)
IncludeMixtures	No

References	13
Patients	32
Isolates	37

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	NRTIs	NNRTIs	NRTIDRMs	NNRTIDRMs	OtherMut	Subtype
Ruiz (1996)	JCS-C45	C45W24	Z99335	AZT, DDI, 3TC	None	M41L, D67N, M184V, L210W, T215Y, K219N		K20R, E44D, V118I, K122E, G196E, Q197T, E203K, Q207K, H208Y, R211A, V245M	B
Hammer (1997)	ACTG320_1279	1279		AZT, DDC	None	M41L, D67N, K70R, L210W, T215Y, K219N		E44D, V60I, V118I, K122E, I135T, G196E, H208Y, R211K, A272P, I293IV, I329V, G359S, A371V, A376T, T377Q, K451R, D460N, R461RK, L469I, H483Y	B
	ACTG320_2337	2337		AZT, DDI	None	M41L, D67N, T69D, L210W, T215Y, K219N		K20R, V35E, T39A, E40F, K43E, V118I, K122KE, E138G, I142T, S162C, G196E, Q207E, R211K, V245VE, A272P, K277R, I293V, E297A, G333E	B
	ACTG320_453	453		AZT, DDI, D4T, 3TC	None	M41L, D67N, L210W, T215Y, K219N	V179E, Y181C	K32DE, V35VL, T39A, E44D, D123E, I135K, S163SC, I167IV, E169ED, K173E, I178L, G196E, T200A, R211K, L228H, A272P, K277R, E297A, V317A, Y342F, R358RK, T377M, K390R, A400T, K431T, V435I, L469I, T470TN, D488X	B
Shafer (1998)	HMDR-3	3-197C	AF047294	AZT, DDI, 3TC, D4T	None	M41L, D67N, M184V, L210W, T215Y, K219N		V35I, E40E*DY, K43N, V60I, A98S, V118I, K122E, I135V, G196GE, Q207E, R211K	B
	HMDR-4	4	AF047299	AZT, DDC, DDI, D4T, 3TC	None	M41L, D67N, L74I, M184V, L210W, T215Y, K219N	A98G	K43E, E44A, K64R, R83K, V118I, Q161P, S163C, G196E, H208Y, R211K, D218E	B
Balotta (2000)	CB-253	CB-253	AF252056	AZT, 3TC, DDI	None	M41L, A62AV, D67N, M184V, L210W, T215Y, K219N		E44D, A114AE, D123E, I135T, I142V, S162A, D177E, T200A, I202V, H208Y, R211K	B
	CB-304	CB-304	AF251981	DDC, AZT, D4T, 3TC	None	M41L, D67N, M184MV, L210W, T215Y, K219N		K20R, V35I, T39A, K43KE, K49R, V118I, A158S, E169D, G196GE, E203K, H208HY, R211K, L282LF, E297R, V317A	B
Falloon (2000)	JF03	JF03-8w	AF227712	AZT, DDI, DDC, D4T, 3TC, ABC	None	M41L, D67N, T69D, M184V, L210W, T215Y, K219N		E44D, A98S, K122E, D123E, D177E, R211K	B
Albrecht (2001)	ACTG364_1204	1204		AZT, DDI, 3TC	None	M41L, D67N, M184L, L210W, T215Y, K219N		I31IL, R83RK, V90I, V118I, K122P, I135IV, S162CY, I178M, G196E, E203V, A272P, K277R	B
	ACTG364_3469	3469		AZT, DDI, 3TC	None	M41L, D67N, M184V, L210W, T215Y, K219N		K43Q, E44A, V118I, A158S, E169ED, G196GE, Q207E, R211K, V245T	B
	ACTG364_6151	6151		DDC, AZT, 3TC	None	M41L, D67N, M184V, L210W, T215Y, K219N		V35I, T39TA, K43E, E44EA, D121Y, K122E, I135T, S162C, K166KQ, D177E, G196E, R211K, A272P, R284RK	B
Gonzales (2001)	CA620	CA1181	AY030417	AZT, DDC, DDI, 3TC	None	M41L, D67N, M184V, L210W, T215Y, K219N		E44D, V60I, V118I, K122E, I135V, G196E, E203K, Q207E, R211K	B
	CA631	CA1203	AY030419	AZT, DDC, D4T, DDI, 3TC	None	M41L, D67N, V75M, M184V, L210W, T215Y, K219N		E6D, V35X, T39A, E44D, V118I, K173T, E203K, Q207D, H208Y, R211K	B
	CA1148	CA2609	AY030459	AZT, DDI, 3TC, D4T	None	M41L, D67N, K70KR, V75M, M184MV, L210W, T215Y, K219N		K20R, E44D, V60I, D123E, I142V, S162Y, G196E, Q197K, H208F, R211K	B
	CA1155	CA2627	AY030464	NRTI	None	M41L, D67N, L210W, T215Y, K219N		V35I, K43Q, E44D, V118I, D121H, K122E, I135T, D177E, G196E, H208Y, R211K, V245K	B
	CA1259	CA3026	AY030488	AZT, DDC, D4T, 3TC	None	M41L, D67N, M184V, L210W, T215Y, K219N		E44D, V118I, K122E, D123E, D177E, I178M, H208Y, R211K, E248D, A272P, K277X, T286A, E297K, A299X	B
	CA1555	CA4444	AY030672	AZT, DDI, NRTI, 3TC, D4T	None	M41L, D67N, K70KR, M184V, T215Y, K219N		K20R, V60I, A98S, I135T, K166R, E169D, G196E, T200A, R211RS, V245M	B
	CA1624	CA4604	AY030712	DDC, AZT, 3TC, D4T, DDI	None	M41L, D67N, L210W, T215Y, K219N		T39A, E44D, H208Y, R211K, V245T, N265NT, K277R, C280CR, R284K, T286A, V292I, E297K	B
	CA2073	CA7679	AY030783	DDC, AZT, DDI, D4T, 3TC	None	M41L, D67N, M184V, L210W, T215Y, K219N		T27S, K43E, E44A, V118I, K122E, I142IV, A158S, I202V, R211K, N265NT, A272P, C280CR	B
	CA3972	CA9217	AY030970	AZT, 3TC, D4T	None	M41L, D67N, M184V, L210W, T215Y, K219N	K101H	K43E, E44A, K122E, I142V, S162C, E169D, H208Y, R211K, V245M	B
	CA5102	CA12385	AY031670	AZT, DDC, 3TC, D4T	None	M41L, D67N, M184V, L210W, T215Y, K219N		K20R, V35X, K43E, E44A, A98S, V118I, K122KE, G196GE, H208Y, R211K, V245K, D250E, S251SC	B
Katzenstein (2001)	ACTG302_2098	2098RT_f1		AZT, DDI, 3TC	None	M41L, D67N, M184V, L210W, T215Y, K219N		R83K, V90I, V118I, K122P, I135V, T139HN, S162C, I178M, G196E, E203V, A272P, K277R, I293V, P294T, E300E*	B
	ACTG302_3623	3623RT_f1		AZT, DDI, 3TC	None	M41L, D67N, M184V, L210W, T215Y, K219N		K11R, Q23QH, K43Q, E44D, V60I, L100LF, V118I, D123E, I135L, S162Y, Q207E, R211K	B
Servais (2001)	JS6	JS98371	AJ401823	AZT, DDI, DDC, D4T, 3TC	None	M41L, D67N, K70R, M184V, L210W, T215Y, K219N		V111I, I135T, S163C, D177E, I178M, E194G, G196E, T200I, H208Y, R211K, V245T	B
Papa (2002)	AP-13	AP-13	AF315756	AZT, 3TC, D4T, DDI	None	M41L, D67N, M184V, L210W, T215Y, K219N		K43KQ, E44D, V118I, K122E, I135T, D177E, V179I, G196E, T200A, E203D, H208Y, R211K	B
Gonzales (2003)	CA1148	CA10560	AF514021	AZT, DDI, 3TC, D4T	None	M41L, D67N, V75M, M184V, L210W, T215Y, K219N		K20R, E44D, V60I, K122KE, D123E, I142V, S162Y, G196E, Q197K, E203D, H208F, R211K, S251I, A272P, I293V	B
		CA35549	AY802725	AZT, DDI, 3TC, D4T	None	M41L, D67N, V75M, M184V, L210W, T215Y, K219N		T7TP, K20R, E44D, V60I, D123E, I142V, S162Y, G196E, Q197K, E203D, H208F, R211K, S251I, A272P, I293V	B
	CA3972	CA17451	AF514168	AZT, 3TC, D4T, ABC	None	M41L, D67N, L74I, L210W, T215Y, K219N	K101H	E40F, K43E, V118I, K122E, S162C, E169D, H208Y, R211K, V245M, Q278QH, I293V	B
Rhee (2005)	CA1148	CA17417	AY800771	AZT, DDI, 3TC, D4T, ABC, NRTI	None	M41L, D67N, K70KR, V75M, M184V, L210W, T215Y, K219N		K20R, K43Q, E44D, V60I, K122E, D123X, I142V, S162Y, G196E, Q197K, E203D, H208F, R211K, S251I, A272P, K281KE, I293V, A299AG	B
	CA1590	CA9315	AY801052	DDC, AZT, D4T, 3TC, DDI	None	M41L, D67N, T69D, M184V, L210W, T215Y, K219N		E44D, V60I, V118I, K122E, I135T, G196E, T200I, E203K, Q207E, H208Y, R211K, K223E	B
	SWC-2224	P2224-464		AZT, DDC, D4T, 3TC	None	M41L, M184V, L210W, T215Y, K219N		E42X, E44X, S68G, R83S, I135T, I178M, R211Q	B
		P2224-773		AZT, DDC, D4T, 3TC	None	M41L, M184V, L210W, T215Y, K219N		S68G, I135T, I178M, R211Q	B
	SWC-4651	P4651-319		DDC, AZT, 3TC, D4T, DDI	None	M41L, M184V, L210W, T215Y, K219N		V35M, T39A, K43E, E44D, D123E, K166R, D177E, I202V, E203D, H208Y, R211K	B
	CA7119	CA17469	AY801790	AZT, DDC, 3TC	None	M41L, D67N, M184V, L210W, T215Y, K219N		K43E, E44A, V60I, V118I, D121Y, K122E, I135T, D177E, I178M, H208Y, R211K, K281KE, V292I, I293V, A299AG	B
	CA14611	CA35024	AY802389	AZT, 3TC	None	M41L, L74I, M184V, L210W, T215Y, K219N		V35VE, T39A, E40F, K43E, V60I, S68G, V118I, K122E, K166R, G196E, T200I, R211K, A272P, I293V, E302D	B
Rodrigues (2005)	BR045	11800	AY441879	D4T, DDI, ABC, AZT, 3TC	None	M41L, D67N, T69D, M184V, L210*W, T215Y, K219N		E6D, T39N, K43E, E44A, A98AP, D110DN, V118I, K122E, I135T, V179I, T200TA, H208Y, R211K, K223Q, V245T	B

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